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hyperthermia sarcoma

Katja Zimmermann, Martin Hossann, Johannes Hirschberger, Karin Troedson, Michael Peller, Moritz Schneider, Andreas Brühschwein, Andrea Meyer-Lindenberg, Gerhard Wess, Melanie Wergin, René Dörfelt, Thomas Knösel, Markus Schwaiger, Christine Baumgartner, Johanna Brandl, Sabine Schwamberger, Lars H Lindner
PURPOSE: Doxorubicin (DOX)-loaded phosphatidyldiglycerol-based thermosensitive liposomes (DPPG2-TSL-DOX) combined with local hyperthermia (HT) were evaluated in cats with locally advanced spontaneous fibrosarcomas (soft tissue sarcoma, STS). The study was designed to evaluate the safety and pharmacokinetic profile of the drug. Results from four dose-levels are reported. METHODS: Eleven client-owned cats with advanced STS were enrolled. Five cats received escalating doses of 0...
September 4, 2016: International Journal of Hyperthermia
Rolf Issels, Lars H Lindner
PURPOSE OF REVIEW: Recent developments of neo-adjuvant chemotherapy treatment strategies for high-risk soft tissue sarcoma (STS) with special emphasis on regional hyperthermia (RHT) are reviewed. RECENT FINDINGS: Attempts to improve outcomes using up-front strategies in addition to surgery have essentially focused on neo-adjuvant and adjuvant chemotherapy or preoperative radiochemotherapy. Unfortunately, the results are either confounded by retrospective analyses of nonrandomized studies with small sample size or are negative showing no substantial clinical benefit in the few randomized trials...
September 2016: Current Opinion in Oncology
Wouter J M Lokerse, Michiel Bolkestein, Timo L M Ten Hagen, Marion de Jong, Alexander M M Eggermont, Holger Grüll, Gerben A Koning
Doxorubicin (Dox) loaded thermosensitive liposomes (TSLs) have shown promising results for hyperthermia-induced local drug delivery to solid tumors. Typically, the tumor is heated to hyperthermic temperatures (41-42 °C), which induced intravascular drug release from TSLs within the tumor tissue leading to high local drug concentrations (1-step delivery protocol). Next to providing a trigger for drug release, hyperthermia (HT) has been shown to be cytotoxic to tumor tissue, to enhance chemosensitivity and to increase particle extravasation from the vasculature into the tumor interstitial space...
2016: Theranostics
Antonios Makridis, Magdalini Tziomaki, Konstantina Topouridou, Maria P Yavropoulou, John G Yovos, Orestis Kalogirou, Theodoros Samaras, Mavroeidis Angelakeris
The present study examines the heating efficiency of a combination of manganese or cobalt ferrites in a binary (Co- or Mn-) ferrite nanoparticle form with magnetite, covered with citric acid to improve biocompatibility. The nanoparticle synthesis is based on the aqueous co-precipitation of proper salts, a facile, low-cost, environmentally friendly and high yield synthetic approach. By detailed structural and magnetic characterisation, the direct influence of structural and magnetic features on magnetic hyperthermia concludes to optimum heating efficiency...
November 2016: International Journal of Hyperthermia
Jenny Shim, Robert M Staruch, Korgun Koral, Xian-Jin Xie, Rajiv Chopra, Theodore W Laetsch
BACKGROUND: Despite intensive therapy, children with metastatic and recurrent sarcoma or neuroblastoma have a poor prognosis. Magnetic resonance guided high intensity focused ultrasound (MR-HIFU) is a noninvasive technique allowing the delivery of targeted ultrasound energy under MR imaging guidance. MR-HIFU may be used to ablate tumors without ionizing radiation or target chemotherapy using hyperthermia. Here, we evaluated the anatomic locations of tumors to assess the technical feasibility of MR-HIFU therapy for children with solid tumors...
October 2016: Pediatric Blood & Cancer
Michael Bordonaro, Senji Shirasawa, Darina L Lazarova
Although neoplastic cells exhibit relatively higher sensitivity to hyperthermia than normal cells, hyperthermia has had variable success as an anti-cancer therapy. This variable outcome might be due to the fact that cancer cells themselves have differential degrees of sensitivity to high temperature. We hypothesized that the varying sensitivity of colorectal cancer (CRC) cells to hyperthermia depends upon the differential induction of survival pathways. Screening of such pathways revealed that Extracellular Signal-Regulated Kinase (ERK) signaling is augmented by hyperthermia, and the extent of this modulation correlates with the mutation status of V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)...
2016: Cancers
Georg Seifert, Volker Budach, Ulrich Keilholz, Peter Wust, Angelika Eggert, Pirus Ghadjar
Here we evaluate the current status of clinical research on regional hyperthermia (RHT) in combination with chemotherapy or radiation therapy in paediatric oncology.Data were identified in searches of MEDLINE, Current Contents, PubMed, and references from relevant articles using medical subject headings including hyperthermia, cancer, paediatric oncology, children, radiation therapy and chemotherapy. Currently, only two RHT centres exist in Europe which treat children. Clinical RHT research in paediatric oncology has as yet been limited to children with sarcomas and germ cell tumours that respond poorly to or recur after chemotherapy...
April 30, 2016: Radiation Oncology
Dominique Harnicek, Eric Kampmann, Kirsten Lauber, Roman Hennel, Ana Sofia Cardoso Martins, Yang Guo, Claus Belka, Simone Mörtl, Eike Gallmeier, Roland Kanaar, Ulrich Mansmann, Tomas Hucl, Lars H Lindner, Wolfgang Hiddemann, Rolf D Issels
The tetrahydroisoquinoline trabectedin is a marine compound with approved activity against human soft-tissue sarcoma. It exerts antiproliferative activity mainly by specific binding to the DNA and inducing DNA double-strand breaks (DSB). As homologous recombination repair (HRR)-deficient tumors are more susceptible to trabectedin, hyperthermia-mediated on-demand induction of HRR deficiency represents a novel and promising strategy to boost trabectedin treatment. For the first time, we demonstrate enhancement of trabectedin effectiveness in human sarcoma cell lines by heat and characterize cellular events and molecular mechanisms related to heat-induced effects...
July 15, 2016: International Journal of Cancer. Journal International du Cancer
Wouter J M Lokerse, Esther C M Kneepkens, Timo L M ten Hagen, Alexander M M Eggermont, Holger Grüll, Gerben A Koning
In numerous studies, thermosensitive liposomes (TSLs) for local heat-triggered delivery of Doxorubicin (Dox) to tumors have been investigated, with TSLs having different lipid formulations, drug loading methodology and testing procedures. To gain more insight in these parameters, we investigated TSLs with four variable DSPC-DPPC lipid ratios (50, 60, 70 or 80% DPPC and 5 mol% of DSPE-PEG2000) using either ammonium sulfate or a citrate buffer for Dox loading. Ammonium sulfate loading of Dox yielded more stable TSLs than citrate loading...
March 2016: Biomaterials
F Stubbe, A Agaimy, O Ott, S Lettmaier, N Vassos, R Croner, W Hohenberger, R Fietkau, S Semrau
PURPOSE: There is a sound theoretical basis but little clinical evidence substantiating the benefits of concurrent chemoradiotherapy with two-drug chemotherapy for locally advanced soft tissue sarcomas. Our five-year data on the feasibility and effectiveness of neoadjuvant chemoradiotherapy with systemically effective doses of adriamycin and ifosfamide combined is presented here. PATIENTS AND METHODS: Between 2000 and 2011, 53 patients with UICC (2010) stage I (n=1, 1...
February 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Linus Willerding, Simone Limmer, Martin Hossann, Anja Zengerle, Kirsten Wachholz, Timo L M Ten Hagen, Gerben A Koning, Ronald Sroka, Lars H Lindner, Michael Peller
Systemic chemotherapy of solid tumors could be enhanced by local hyperthermia (HT) in combination with thermosensitive liposomes (TSL) as drug carriers. In such an approach, effective HT of the tumor is considered essential for successful triggering local drug release and targeting of the drug to the tumor. To investigate the effect of HT method on the effectiveness of drug delivery, a novel laser-based HT device designed for the use in magnetic resonance imaging (MRI) was compared systematically with the frequently used cold light lamp and water bath HT...
January 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Frederik F Strobl, Houman Azam, Jens B Schwarz, Philipp M Paprottka, Tobias Geith, Sultan Abdel-Rahman, Benjamin Zilles, Lars H Lindner, Maximilian F Reiser, Christoph G Trumm
PURPOSE: This study was designed to assess technical success and complications in patients with high-risk soft tissue sarcomas undergoing CT fluoroscopy-guided closed-tip catheter placement before treatment with combined chemotherapy and regional hyperthermia. MATERIALS AND METHODS: This retrospective study comprised all patients referred for insertion of closed-tip catheters for the introduction of thermometry probes before regional hyperthermia treatment at a single university centre from 2010 to 2015...
2016: International Journal of Hyperthermia
Yusuf Valentino Kaneti, Chuyang Chen, Minsu Liu, Xiaochun Wang, Jia Lin Yang, Robert Allen Taylor, Xuchuan Jiang, Aibing Yu
Gold nanorods and their core-shell nanocomposites have been widely studied because of their well-defined anisotropy and unique optical properties and applications. This study demonstrates a facile hydrothermal synthesis strategy for generating carbon coating on gold nanorods (AuNRs@C) under mild conditions (<200 °C), where the carbon shell is composed of polymerized sugar molecules (glucose). The structure and composition of the produced core-shell nanocomposites were characterized using advanced microscopic and spectroscopic techniques...
November 25, 2015: ACS Applied Materials & Interfaces
G I Gafton, Yu V Semiletova, K Yu Senchik, A M Belyaev, I G Gafton, V G Petrov, V G Lemekhov
A steady increase of incidence of skin melanoma and soft tissue sarcomas of the extremities currently continues to be observed. Taking into account the high probability of developing of locally disseminated forms of skin melanoma and soft tissue sarcomas of extremities, the need to use combined methods in their treatment is quite high. In the 21st century the possibility of a use of isolated regional chemoperfusion provides a high objective response of tumor to chemotherapy without their systemic impact and improves the quality of life through preservation of the limb...
2015: Voprosy Onkologii
A M Belyaev, G I Gafton, E V Levchenko, A M Karachun, A V Gulyaev, K Yu Senchik, V G Bespalov, I V Berlev, A F Urmancheeva, K D Guseinov, Yu V Semiletova, O N Mamontov, P V Kalinin, G S Kireeva, O A Belyaeva, V V Alexeev
The data of literature on possibility of the use of perfusion technologies in combined treatment for malignant tumors of different sites are presented. Possible complications during hyperthermic chemoperfusion are discussed and the effectiveness of this method is analyzed.
2015: Voprosy Onkologii
John Spiliotis, Evgenia E Halkia, Nausika Kalantzi, Stylianos Giassas, Evangelos Lianos, Elias Efstathiou, Paul H Sugarbaker
PURPOSE: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising treatment for patients with peritoneal carcinomatosis (PC). Our objective was to identify new prognostic factors within the Peritoneal Cancer Index (PCI) score in PC patients. METHODS: 140 patients (60 ovarian, 45 colon, 14 gastric, 10 pseudomyxoma peritonei, 5 mesothelioma, 6 sarcoma) with PC treated with CRS+HIPEC from 2007 to December 2013 were retrospectively included...
May 2015: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Christian Rossmanna, Dieter Haemmerich
The application of supraphysiological temperatures (>40°C) to biological tissues causes changes at the molecular, cellular, and structural level, with corresponding changes in tissue function and in thermal, mechanical and dielectric tissue properties. This is particularly relevant for image-guided thermal treatments (e.g. hyperthermia and thermal ablation) delivering heat via focused ultrasound (FUS), radiofrequency (RF), microwave (MW), or laser energy; temperature induced changes in tissue properties are of relevance in relation to predicting tissue temperature profile, monitoring during treatment, and evaluation of treatment results...
2014: Critical Reviews in Biomedical Engineering
Nick Frazier, Ryan Robinson, Abhijit Ray, Hamidreza Ghandehari
Previously, water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers have been used with gold nanorod (GNR) mediated plasmonic photothermal therapy (PPTT) to induce hyperthermia (43 °C for 10 min) and have been shown to improve delivery of hydrophobic drugs to treat cancer. However, it was unknown how altering the heating parameters (temperature and duration) of PPTT would affect HPMA copolymer accumulation and retention. This study aimed to investigate how changes in heating parameters, or thermal dose, would change polymer accumulation profiles with PPTT...
May 4, 2015: Molecular Pharmaceutics
Minglun LI, Claudia Andrä, Maximilian Niyazi, Rolf D Issels, Sultan Abdel-Rahman, Feras Oskan, Farkhad Manapov
We hereby present a case of pre-treated unresectable sarcoma recurrence of the trunk which showed an excellent response to concomitant tri-modal therapy, consisting of re-irradiation, chemotherapy and regional hyperthermia even with a strong compromised re-irradiation dose. No significant toxicity of the combined therapy and fast achievement of the pain and neurological symptoms relief are reported. The case shows that concurrent tri-modality treatment can be considered as a therapeutic option for the management of pre-treated unresectable recurrence even in there-irradiation setting...
March 2015: Tumori
E Halkia, A Tsochrinis, D T Vassiliadou, A Pavlakou, A Vaxevanidou, A Datsis, E Efstathiou, J Spiliotis
BACKGROUND: Peritoneal carcinomatosis (PC) is associated with a poor prognosis. Cytoreductive surgery (CRS) and HIPEC play an important role in well-selected patients with PC. The aim of the study is to present the differences in the intraoperative parameters in patients who received HIPEC in two different manners, open versus closed abdomen. PATIENTS AND METHODS: The population includes 105 patients with peritoneal carcinomatosis from colorectal, gastric, and ovarian cancer, sarcoma, mesothelioma, and pseudomyxoma peritonei...
2015: International Journal of Surgical Oncology
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