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hyperthermia sarcoma

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https://www.readbyqxmd.com/read/29659611/preoperative-evaluation-of-the-efficacy-of-radio-hyperthermo-chemotherapy-for-soft-tissue-sarcoma-in-a-case-series
#1
Hisaki Aiba, Satoshi Yamada, Jun Mizutani, Norio Yamamoto, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Akihiko Takeuchi, Shinji Miwa, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Yoshihiro Araki, Hiroyuki Tsuchiya, Takanobu Otsuka
PURPOSE: Radio-hyperthermo-chemo (RHC) therapy, which combines radiotherapy, hyperthermia, and chemotherapy, for malignant soft tissue tumors has been introduced with the aim of decreasing the possibility of local recurrence after surgery. To avoid unnecessary neoadjuvant therapy and to plan the appropriate surgical treatment, surveillance of RHC therapeutic efficacy during treatment is necessary. In this study, we determined the optimal response criteria to evaluate the efficacy of RHC by comparing preoperative images before and after RHC with pathological evaluation of necrosis in the resected tumor...
2018: PloS One
https://www.readbyqxmd.com/read/29508856/sarcoma-local-hyperthermia-improves-survival
#2
David Killock
No abstract text is available yet for this article.
March 6, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29479833/clinical-outcomes-of-radio-hyperthermo-chemotherapy-for-soft-tissue-sarcoma-compared-to-a-soft-tissue-sarcoma-registry-in-japan-a-retrospective-matched-pair-cohort-study
#3
Hisaki Aiba, Satoshi Yamada, Jun Mizutani, Norio Yamamoto, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Akihiko Takeuchi, Shinji Miwa, Akira Kawai, Kenichi Yoshimura, Hiroyuki Tsuchiya, Otsuka Takanobu
Regional hyperthermia is considered to enhance the antitumor effects of chemotherapy and radiotherapy. In this study, we confirmed the efficacy of concomitant radiotherapy, hyperthermia, and chemotherapy (RHC) for neoadjuvant treatment of malignant soft tissue sarcoma (STS). From 1994 to 2013, we performed RHC in 150 patients. This study was limited to 60 patients using the following exclusion criteria: salvage for recurrence or unplanned excision, trunk location, metastasis at initiation, non-STS, and no definitive surgery...
February 26, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29450459/technological-advances-biologic-rationales-and-the-associated-success-of-chemotherapy-with-hyperthermia-in-improved-outcomes-in-patients-with-sarcoma
#4
Mark W Dewhirst, David Kirsch
No abstract text is available yet for this article.
February 15, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29450452/effect-of-neoadjuvant-chemotherapy-plus-regional-hyperthermia-on-long-term-outcomes-among-patients-with-localized-high-risk-soft-tissue-sarcoma-the-eortc-62961-esho-95-randomized-clinical-trial
#5
Rolf D Issels, Lars H Lindner, Jaap Verweij, Rüdiger Wessalowski, Peter Reichardt, Peter Wust, Pirus Ghadjar, Peter Hohenberger, Martin Angele, Christoph Salat, Zeljko Vujaskovic, Soeren Daugaard, Olav Mella, Ulrich Mansmann, Hans Roland Dürr, Thomas Knösel, Sultan Abdel-Rahman, Michael Schmidt, Wolfgang Hiddemann, Karl-Walter Jauch, Claus Belka, Alessandro Gronchi
Importance: Patients with soft tissue sarcoma are at risk for local recurrence and distant metastases despite optimal local treatment. Preoperative anthracycline plus ifosfamide chemotherapy improves outcome in common histological subtypes. Objective: To analyze whether the previously reported improvement in local progression-free survival by adding regional hyperthermia to neoadjuvant chemotherapy translates into improved survival. Design, Setting, and Participants: Open-label, phase 3 randomized clinical trial to evaluate the efficacy and toxic effects of neoadjuvant chemotherapy plus regional hyperthermia...
February 15, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29284287/recombinant-adenovirus-p53-gene-therapy-for-advanced-unresectable-soft-tissue-sarcomas
#6
Shao Wen Xiao, Yi-Zhi Xu, Bu-Fan Xiao, Jing Jiang, Chang-Qing Liu, Zhi-Wei Fang, Dong-Ming Li, Xiao Fan Li, Yong Cai, Yong Heng Li, Yan Sun, Xing Su, Guang-Ying Zhu, Shan Wen Zhang
Patients with unresectable advanced soft-tissue sarcomas (STS) receiving radiotherapy or/and chemotherapy still have a poor prognosis. This study aimed to evaluate retrospectively the efficacy and safety of recombinant adenovirus-p53 (rAd-p53) gene therapy combined with radiotherapy and hyperthermia for advanced STS. A total of 71 patients with advanced unresectable STS treated at the authors' center from April 2007 to November 2014 were included. Of these 71 patients, 36 cases received rAd-p53 therapy combined with radiotherapy and hyperthermia (p53 group), while 35 cases received radiotherapy and hyperthermia alone (control group)...
March 2, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29192019/pre-and-postoperative-chemotherapy-in-localized-extremity-soft-tissue-sarcoma-a-european-organization-for-research-and-treatment-of-cancer-expert-survey
#7
REVIEW
Christian Rothermundt, Galina F Fischer, Sebastian Bauer, Jean-Yves Blay, Viktor Grünwald, Antoine Italiano, Bernd Kasper, Attila Kollár, Lars H Lindner, Aisha Miah, Stefan Sleijfer, Silvia Stacchiotti, Paul Martin Putora
BACKGROUND: The management of localized extremity soft tissue sarcomas (STS) is challenging and the role of pre- and postoperative chemotherapy is unclear and debated among experts. MATERIALS AND METHODS: Medical oncology experts of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group were asked to participate in this survey on the use of pre- and postoperative chemotherapy in STS. Experts from 12 centers in Belgium, France, Germany, Great Britain, Italy, Switzerland, and The Netherlands agreed to participate and provided their treatment algorithm...
November 30, 2017: Oncologist
https://www.readbyqxmd.com/read/28826283/radiotherapy-and-hyperthermia-with-curative-intent-in-recurrent-high-risk-soft-tissue-sarcomas
#8
Franziska Eckert, Lore Helene Braun, Frank Traub, Hans-Georg Kopp, Bence Sipos, Ulf Lamprecht, Arndt-Christian Müller, Frank Paulsen, Daniel Zips
PURPOSE: Radiotherapy before or after resection is one of the pillars of treatment for localised high risk soft tissue sarcomas. Treatment intensification has been described with concurrent chemotherapy and hyperthermia. The aim of this study is to assess local control after multimodal treatment, focussing on the treatment of local recurrences after surgery only. PATIENTS AND METHODS: Of 42 patients treated in a prospective protocol with radiotherapy and hyperthermia, nine were treated for isolated local recurrences without metastatic spread...
August 21, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28661574/hyperthermia-effect-and-antibacterial-efficacy-of-fe-3-co-2-co-substitutions-in-%C3%AE-ca3-po4-2-for-bone-cancer-and-defect-therapy
#9
Ram Kishore Singh, M Srivastava, N K Prasad, P H Shetty, S Kannan
The combined effect of cobalt and iron substitutions in β-Ca3 (PO4 )2 as a potent material for application in hyperthermia and as a bone substitute is presented. Structural analysis reveals the preferential accommodation of Co(2+) and Fe(3+) at the Ca(2+) (5) sites of β-Ca3 (PO4 )2 until the limit of ∼10 mol % and, thereafter, prefer Ca(2+) (4) lattice sites. Occupancy of both the Co(2+) and Fe(3+) ions induces a significant contraction of the β-Ca3 (PO4 )2 unit cell. The Co(2+) /Fe(3+) co-substitutions in β-Ca3 (PO4 )2 display magnetic characteristics that enhances hyperthermia effect...
June 29, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28306552/precise-determination-of-the-heat-delivery-during-in-vivo-magnetic-nanoparticle-hyperthermia-with-infrared-thermography
#10
Harley F Rodrigues, Gustavo Capistrano, Francyelli M Mello, Nicholas Zufelato, Elisângela Silveira-Lacerda, Andris F Bakuzis
Non-invasive and real-time monitoring of the heat delivery during magnetic nanoparticle hyperthermia (MNH) is of fundamental importance to predict clinical outcomes for cancer treatment. Infrared thermography (IRT) can determine the surface temperature due to three-dimensional heat delivery inside a subcutaneous tumor, an argument that is supported by numerical simulations. However, for precise temperature determination, it is of crucial relevance to use a correct experimental configuration. This work reports an MNH study using a sarcoma 180 murine tumor containing 3...
May 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27592502/a-pilot-trial-of-doxorubicin-containing-phosphatidyldiglycerol-based-thermosensitive-liposomes-in-spontaneous-feline-soft-tissue-sarcoma
#11
Katja Zimmermann, Martin Hossann, Johannes Hirschberger, Karin Troedson, Michael Peller, Moritz Schneider, Andreas Brühschwein, Andrea Meyer-Lindenberg, Gerhard Wess, Melanie Wergin, René Dörfelt, Thomas Knösel, Markus Schwaiger, Christine Baumgartner, Johanna Brandl, Sabine Schwamberger, Lars H Lindner
PURPOSE: Doxorubicin (DOX)-loaded phosphatidyldiglycerol-based thermosensitive liposomes (DPPG2-TSL-DOX) combined with local hyperthermia (HT) were evaluated in cats with locally advanced spontaneous fibrosarcomas (soft tissue sarcoma, STS). The study was designed to evaluate the safety and pharmacokinetic profile of the drug. Results from four dose-levels are reported. METHODS: Eleven client-owned cats with advanced STS were enrolled. Five cats received escalating doses of 0...
September 4, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27455134/regional-hyperthermia-for-high-risk-soft-tissue-sarcoma-treatment-present-status-and-next-questions
#12
REVIEW
Rolf Issels, Lars H Lindner
PURPOSE OF REVIEW: Recent developments of neo-adjuvant chemotherapy treatment strategies for high-risk soft tissue sarcoma (STS) with special emphasis on regional hyperthermia (RHT) are reviewed. RECENT FINDINGS: Attempts to improve outcomes using up-front strategies in addition to surgery have essentially focused on neo-adjuvant and adjuvant chemotherapy or preoperative radiochemotherapy. Unfortunately, the results are either confounded by retrospective analyses of nonrandomized studies with small sample size or are negative showing no substantial clinical benefit in the few randomized trials...
September 2016: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27446503/investigation-of-particle-accumulation-chemosensitivity-and-thermosensitivity-for-effective-solid-tumor-therapy-using-thermosensitive-liposomes-and-hyperthermia
#13
Wouter J M Lokerse, Michiel Bolkestein, Timo L M Ten Hagen, Marion de Jong, Alexander M M Eggermont, Holger Grüll, Gerben A Koning
Doxorubicin (Dox) loaded thermosensitive liposomes (TSLs) have shown promising results for hyperthermia-induced local drug delivery to solid tumors. Typically, the tumor is heated to hyperthermic temperatures (41-42 °C), which induced intravascular drug release from TSLs within the tumor tissue leading to high local drug concentrations (1-step delivery protocol). Next to providing a trigger for drug release, hyperthermia (HT) has been shown to be cytotoxic to tumor tissue, to enhance chemosensitivity and to increase particle extravasation from the vasculature into the tumor interstitial space...
2016: Theranostics
https://www.readbyqxmd.com/read/27442884/a-novel-strategy-combining-magnetic-particle-hyperthermia-pulses-with-enhanced-performance-binary-ferrite-carriers-for-effective-in-vitro-manipulation-of-primary-human-osteogenic-sarcoma-cells
#14
Antonios Makridis, Magdalini Tziomaki, Konstantina Topouridou, Maria P Yavropoulou, John G Yovos, Orestis Kalogirou, Theodoros Samaras, Mavroeidis Angelakeris
The present study examines the heating efficiency of a combination of manganese or cobalt ferrites in a binary (Co- or Mn-) ferrite nanoparticle form with magnetite, covered with citric acid to improve biocompatibility. The nanoparticle synthesis is based on the aqueous co-precipitation of proper salts, a facile, low-cost, environmentally friendly and high yield synthetic approach. By detailed structural and magnetic characterisation, the direct influence of structural and magnetic features on magnetic hyperthermia concludes to optimum heating efficiency...
November 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27199087/pediatric-sarcomas-are-targetable-by-mr-guided-high-intensity-focused-ultrasound-mr-hifu-anatomical-distribution-and-radiological-characteristics
#15
Jenny Shim, Robert M Staruch, Korgun Koral, Xian-Jin Xie, Rajiv Chopra, Theodore W Laetsch
BACKGROUND: Despite intensive therapy, children with metastatic and recurrent sarcoma or neuroblastoma have a poor prognosis. Magnetic resonance guided high intensity focused ultrasound (MR-HIFU) is a noninvasive technique allowing the delivery of targeted ultrasound energy under MR imaging guidance. MR-HIFU may be used to ablate tumors without ionizing radiation or target chemotherapy using hyperthermia. Here, we evaluated the anatomic locations of tumors to assess the technical feasibility of MR-HIFU therapy for children with solid tumors...
October 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27187477/in-hyperthermia-increased-erk-and-wnt-signaling-suppress-colorectal-cancer-cell-growth
#16
Michael Bordonaro, Senji Shirasawa, Darina L Lazarova
Although neoplastic cells exhibit relatively higher sensitivity to hyperthermia than normal cells, hyperthermia has had variable success as an anti-cancer therapy. This variable outcome might be due to the fact that cancer cells themselves have differential degrees of sensitivity to high temperature. We hypothesized that the varying sensitivity of colorectal cancer (CRC) cells to hyperthermia depends upon the differential induction of survival pathways. Screening of such pathways revealed that Extracellular Signal-Regulated Kinase (ERK) signaling is augmented by hyperthermia, and the extent of this modulation correlates with the mutation status of V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)...
2016: Cancers
https://www.readbyqxmd.com/read/27138749/regional-hyperthermia-combined-with-chemotherapy-in-paediatric-adolescent-and-young-adult-patients-current-and-future-perspectives
#17
REVIEW
Georg Seifert, Volker Budach, Ulrich Keilholz, Peter Wust, Angelika Eggert, Pirus Ghadjar
Here we evaluate the current status of clinical research on regional hyperthermia (RHT) in combination with chemotherapy or radiation therapy in paediatric oncology.Data were identified in searches of MEDLINE, Current Contents, PubMed, and references from relevant articles using medical subject headings including hyperthermia, cancer, paediatric oncology, children, radiation therapy and chemotherapy. Currently, only two RHT centres exist in Europe which treat children. Clinical RHT research in paediatric oncology has as yet been limited to children with sarcomas and germ cell tumours that respond poorly to or recur after chemotherapy...
April 30, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/26933761/hyperthermia-adds-to-trabectedin-effectiveness-and-thermal-enhancement-is-associated-with-brca2-degradation-and-impairment-of-dna-homologous-recombination-repair
#18
Dominique Harnicek, Eric Kampmann, Kirsten Lauber, Roman Hennel, Ana Sofia Cardoso Martins, Yang Guo, Claus Belka, Simone Mörtl, Eike Gallmeier, Roland Kanaar, Ulrich Mansmann, Tomas Hucl, Lars H Lindner, Wolfgang Hiddemann, Rolf D Issels
The tetrahydroisoquinoline trabectedin is a marine compound with approved activity against human soft-tissue sarcoma. It exerts antiproliferative activity mainly by specific binding to the DNA and inducing DNA double-strand breaks (DSB). As homologous recombination repair (HRR)-deficient tumors are more susceptible to trabectedin, hyperthermia-mediated on-demand induction of HRR deficiency represents a novel and promising strategy to boost trabectedin treatment. For the first time, we demonstrate enhancement of trabectedin effectiveness in human sarcoma cell lines by heat and characterize cellular events and molecular mechanisms related to heat-induced effects...
July 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/26761778/in-depth-study-on-thermosensitive-liposomes-optimizing-formulations-for-tumor-specific-therapy-and-in%C3%A2-vitro-to-in%C3%A2-vivo-relations
#19
COMPARATIVE STUDY
Wouter J M Lokerse, Esther C M Kneepkens, Timo L M ten Hagen, Alexander M M Eggermont, Holger Grüll, Gerben A Koning
In numerous studies, thermosensitive liposomes (TSLs) for local heat-triggered delivery of Doxorubicin (Dox) to tumors have been investigated, with TSLs having different lipid formulations, drug loading methodology and testing procedures. To gain more insight in these parameters, we investigated TSLs with four variable DSPC-DPPC lipid ratios (50, 60, 70 or 80% DPPC and 5 mol% of DSPE-PEG2000) using either ammonium sulfate or a citrate buffer for Dox loading. Ammonium sulfate loading of Dox yielded more stable TSLs than citrate loading...
March 2016: Biomaterials
https://www.readbyqxmd.com/read/26700874/effective-local-control-of-advanced-soft-tissue-sarcoma-with-neoadjuvant-chemoradiotherapy-and-surgery-a-single-institutional-experience
#20
F Stubbe, A Agaimy, O Ott, S Lettmaier, N Vassos, R Croner, W Hohenberger, R Fietkau, S Semrau
PURPOSE: There is a sound theoretical basis but little clinical evidence substantiating the benefits of concurrent chemoradiotherapy with two-drug chemotherapy for locally advanced soft tissue sarcomas. Our five-year data on the feasibility and effectiveness of neoadjuvant chemoradiotherapy with systemically effective doses of adriamycin and ifosfamide combined is presented here. PATIENTS AND METHODS: Between 2000 and 2011, 53 patients with UICC (2010) stage I (n=1, 1...
February 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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