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Tongue squamous Cell carcinoma

Hujie Chen, Jing Dai
The aim of the present study is to investigate the role of microRNA (miRNA/miR)-409-3p in the proliferation, invasion and migration of tongue squamous cell carcinoma (TSCC) cells via targeting radixin ( RDX ) gene. The expression of miR-409-3p was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in TSCC tissue and cell lines. The binding of miR-409-3p to RDX was investigated by performing a dual-luciferase reporter gene assay. Tca8113 cells were selected to transfect with miR-409-3p mimic/inhibitor, small interfering (si)-RDX, and miR-409-3p inhibitor + si-RDX, as well as negative control (NC) respectively...
July 2018: Oncology Letters
Robbie S R Woods, Lina Geyer, Ana Ionescu, Deirdre Callanan, Patrick Sheahan
BACKGROUND: The optimal treatment for oropharyngeal squamous cell carcinoma (OPSCC) is controversial. There is increasing evidence that, in selected cases, minimally invasive transoral surgery can offer improved functional outcomes, with equivalent oncologic outcomes, compared to chemoradiotherapy. AIMS: We report the outcomes of transoral laser microsurgery (TLM) for treatment of OPSCC at our institution. METHODS: Patients with OPSCC undergoing TLM at the South Infirmary Victoria University Hospital, Cork, between 2010 and 2016, were identified from an institutional database...
June 21, 2018: Irish Journal of Medical Science
Cinzia Bersani, Michael Mints, Nikolaos Tertipis, Linnea Haeggblom, Anders Näsman, Mircea Romanitan, Tina Dalianis, Torbjörn Ramqvist
OBJECTIVE: Three-year disease-free survival (DFS) is 80% for human papillomavirus (HPV) positive tonsillar and base of tongue cancer (TSCC/BOTSCC) treated with radiotherapy alone, and today's intensified therapy does not improve prognosis. More markers are therefore needed to more accurately identify patients with good prognosis or in need of alternative therapy. Here, microRNAs (miRs) 155, 185 and 193b were examined as potential prognostic markers in TSCC/BOTSCC. MATERIAL AND METHODS: 168 TSCC/BOTSCC patients diagnosed 2000-2013, with known data on HPV-status, CD8+ tumour infiltrating lymphocytes, tumour staging and survival were examined for expression of miR-155, -185 and -193b using Real-Time PCR...
July 2018: Oral Oncology
Yung-Jen Cheng, Mu-Hung Tsai, Chun-Ju Chiang, Sen-Tien Tsai, Tsang-Wu Liu, Pei-Jen Lou, Chun-Ta Liao, Jin-Ching Lin, Joseph Tung-Chieh Chang, Ming-Hsui Tsai, Pen-Yuan Chu, Yi-Shing Leu, Kuo-Yang Tsai, Shyuang-Der Terng, Chih-Yen Chien, Muh-Hwa Yang, Sheng-Po Hao, Chuan-Cheng Wang, Ming-Hsun Tsai, Helen H W Chen, Chin Kuo, Yuan-Hua Wu
Conduct an accurate risk assessment of resected oral cavity squamous cell carcinoma (OSCC) patients by accessing a nationwide systemic investigation is pivotal to improve treatment outcomes. In this article, we tried to determine the impact of different prognostic factors for OSCC patients who received adjuvant radiotherapy (RT) after curative surgery, using Taiwan's national cancer registry database (TCR). A nationwide, large population-based study was conducted using TCR with patients identified from 2007 to 2015...
June 14, 2018: Cancer Medicine
Jiao Chen, Bomiao Cui, Yaping Fan, Xiaoying Li, Qian Li, Yue Du, Yun Feng, Ping Zhang
Protein kinase D1 (PKD1), one of the protein kinase D (PKD) family members, plays a prominent role in multiple bio-behaviors of cancer cells. Low pH and hypoxia are unique characteristics of the tumor microenvironment. The aim of this study was to investigate the role and mechanism of PKD1 in regulating metabolism in the human tongue squamous cell carcinoma (TSCC) cell line SCC25 under a hypoxic condition, as well as growth and apoptosis. Here, we found that hypoxia not only induced the expression of HIF-1α, but also induced the expression and activation of PKD1...
June 7, 2018: Oncology Reports
Rongrui Li, Shichen Liu, Yao Li, Qingxi Tang, Yunchuan Xie, Raosheng Zhai
Long noncoding RNA AFAP1‑AS1 has been shown to promote tumor progression in several human cancer types, such as thyroid cancer, tongue squamous cell carcinoma and lung cancer. However, the role of AFAP1‑AS1 in osteosarcoma (OS) has not been investigated. In the present study, the expression of AFAP1‑AS1 was significantly upregulated in OS tissues and cell lines. Moreover, AFAP1‑AS1 expression was negatively correlated with OS patient prognosis. Besides, AFAP1‑AS1 knockdown significantly inhibited the proliferation and invasion of OS cells in vitro...
June 5, 2018: Molecular Medicine Reports
Kumpol Aiempanakit
No abstract text is available yet for this article.
March 2018: JAAD Case Reports
Yoshiki Nariai, Sho Odawara, Tomoko Ichiyama, Jun-Ichi Akutsu, Takahiro Kanno, Joji Sekine
Fracture of the clavicle following radical neck dissection (RND) and/or radiotherapy is a rare complication. Several causes of fracture of the clavicle after treatment of head and neck cancer were postulated in previous reports. We present a case of fracture of the clavicle after treatment of squamous cell carcinoma of the tongue. An 81-year-old Japanese woman underwent RND, subtotal glossectomy, reconstruction using a pectoralis major myocutaneous flap (PMMCF), and postoperative radiotherapy (50.4 Gy). One month after the primary treatment, fracture of the clavicle occurred...
June 2018: Craniomaxillofacial Trauma & Reconstruction
Z P Li, J Meng, H J Wu, J Zhang, Q P Gu
To explore the clinical value of superselective lingual artery embolization in treating the severe hemorrhage in patients with advanced carcinoma of tongue. Four patients with advanced tongue cancer hemorrhage from March 2014 to February 2016 were enrolled in this study. T3N2M0 (2 cases) and T4N1M0 (2 cases) were diagnosed preoperatively. Two cases of advanced tongue carcinoma tumors had severe bleeding and the other 2 cases of hemorrhage were after radiotherapy. All cases including 3 squamous cell carcinoma and 1 adenocarcinoma were firstly demonstrated by arterigraphy under seldinger technique with digtial subtraction angiogarphy to ensure the rupture site and then all cases were followed by superselective artery embolization...
June 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Glenn J Hanna, Eric R Kofman, Muhammad Ali Shazib, Sook-Bin Woo, Brendan Reardon, Nathaniel S Treister, Robert I Haddad, Corey S Cutler, Joseph H Antin, Eliezer M Van Allen, Ravindra Uppaluri, Robert J Soiffer
OBJECTIVES: Secondary oral squamous cell carcinoma (OSCC) is a late complication in allogeneic hematopoietic stem cell transplantation (HSCT) patients, but little is known about long-term outcomes and prognostication. Additionally, molecular alterations and immunologic insights unique to this disease remain largely unexplored. METHODS: We present a cohort of 31 patients with post-HSCT OSCC and reported on clinicopathologic predictors of survival. Whole-exome sequencing was performed on 6 (19%) matched pairs of peripheral blood (post-conditioning, pre-HSCT) and tumor samples...
June 2018: Oral Oncology
Dae-Seok Hwang, Jinyoung Park, Uk-Kyu Kim, Hae-Ryoun Park, Gyoo-Cheon Kim, Mi-Heon Ryu
Background: Squamous cell carcinoma (SCC) is the most commonly occurring malignant tumor in the oral cavity. In South Korea, it occurs most frequently in the mandible, tongue, maxilla, buccal mucosa, other areas of the oral cavity, and lips. Radial forearm free flap (RFFF) is the most widely used reconstruction method for the buccal mucosal defect. The scar of the forearm donor, however, is highly visible and unsightly, and a secondary surgical site is needed when such technique is applied...
December 2018: Maxillofacial Plastic and Reconstructive Surgery
Ebenezer O Appah, Billy Ray Ballard, Michael G Izban, Cassandra Jolin, Philip E Lammers, Dwight D Parrish, Dana R Marshall
Oral tongue squamous cell carcinoma (OTSCC) has a median age at diagnosis of 62 years. The incidence of OTSCC in young adults has been increasing, and the reason is unclear. The present study describes a case, and molecular analysis, of OTSCC in a 21-year-old female. Clinical and pathological information were collected from medical records. Formalin-fixed paraffin-embedded biopsy tissue from the patient was reassessed using standard hematoxylin & eosin staining, and immunohistochemistry was used to assess the expression of cellular p16, MutL homolog (MLH)1, MLH2, MutS homolog 6 (MSH6) and PMS1 homolog 2 (PMS2)...
May 2018: Oncology Letters
Megan L Adelman, Quoc-Anh Ho, Amit Agrawal
Bazex syndrome (acrokeratosis paraneoplastica) is an uncommon dermatologic condition associated with an underlying malignancy, most commonly squamous cell carcinomas of the head and neck. This article describes Bazex syndrome in a 56-year-old woman who presented with bilateral cervical lymphadenopathy and a mass at the base of her tongue.
June 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
Mingli Duan, Xiaoming Du, Gang Ren, Yongdong Zhang, Yu Zheng, Shuping Sun, Jun Zhang
Migration and invasion are the most important characteristics of human malignancies which limit cancer drug therapies in the clinic. Tongue squamous cell carcinoma (TSCC) is one of the rarest types of cancer, although it is characterized by a higher incidence, rapid growth and greater potential for metastasis compared with other oral neoplasms worldwide. Studies have demonstrated that the phenolic compound obovatol exhibits anti‑tumor effects. However, the potential mechanisms underlying obovatol‑mediated signaling pathways have not been completely elucidated in TSCC...
May 25, 2018: Molecular Medicine Reports
Hirotaka Ota, Takashi Shionome, Hisashi Suguro, Satsuki Saito, Kosuke Ueki, Yoshinori Arai, Masatake Asano
The effect of NiCl2 on oral squamous cell carcinoma-derived cell line HSC3 was examined. Incubation with 1 mM NiCl2 significantly reduced the expression of MMPs at mRNA and protein levels. The in vivo orthotopic implantation model was established by injecting highly metastatic subcell line HSC3-M3 to nude mouse tongue. After 1 week of injection, mice were fed with or without 1 mM NiCl2 -containing water for two to three weeks. Immunohistochamical examination revealed that MMP9 expression was drastically reduced in NiCl2-fed mice...
May 8, 2018: Oncotarget
Wen-Hui Liu, Xin Li, Xin-Ling Zhu, Mei-Ling Hou, Wei Zhao
The present study evaluated the expression and potential role of CD63 in the migration and invasion of tongue squamous cell carcinoma (TSCC) cells. Immunohistochemistry (IHC) was used to investigate the association between the expression level of CD63 protein and the histological differentiation of samples from 40 patients with TSCC and four normal tongue tissue specimens. RNA interference (RNAi) and gene transfection technology were used to alter the expression of CD63 in TCA8113 cells. The stable silencing and overexpression of CD63 in the TCA8113 cell line was used to assess the impact of the CD63 expression level on the migratory and invasive abilities of TCA8113 cells in a wound healing assay and a Transwell invasion assay...
June 2018: Oncology Letters
Nosheen Kanchwala, Naveen Kumar, Shobhit Gupta, Hozefa Lokhandwala
BACKGROUND: To evaluate the changes of oral mucosa in malignancy and pre-malignant oral conditions using fluorescence spectroscopy during various phases of treatment. MATERIAL AND METHODS: The study involved patients of squamous cell carcinoma of the oral cavity and the premalignant lesions coming for the follow up/post-operative radiotherapy. The autofluorescence spectra were recorded in vivo using a Nitrogen laser based fluorimeter. Three sites of each patient were examined-right & the left buccal mucosa and the tongue...
May 25, 2018: International Journal of Surgery
Shogo Kikuta, Keita Todoroki, Naoko Seki, Jingo Kusukawa
Adenosquamous carcinoma (ASC) is a rare malignant tumor of the oral and maxillofacial region that displays histologic features of both adenocarcinoma and squamous cell carcinoma. ASC in the midline dorsum of the tongue is exceedingly rare. We report the case of a 48-year-old man who presented with a painless mass in the midline dorsum of the tongue. Although the case was diagnosed as adenocarcinoma by biopsy, a final diagnosis of ASC was established after surgery. Ten months after the patient's initial visit, no recurrence or metastasis has been noted...
May 1, 2018: Journal of Oral and Maxillofacial Surgery
Zhibin Zuo, Long Ma, Zuode Gong, Lande Xue, Qibao Wang
Long non-coding RNAs (lncRNAs) have gained a lot of attention because they participate in several human disorders, including tumors. This study determined the role of LncRNA CASC15 (cancer susceptibility candidate 15) in the development of tongue squamous cell carcinoma (TSCC). Here, we identified that CASC15 expression was upregulated in TSCC samples and cell lines. We showed that overexpression of CASC15 promoted cell proliferation, cycle, and migration in TSCC. In addition, we revealed that miR-33a-5p expression was downregulated in TSCC tissues and cell lines...
May 26, 2018: Environmental Science and Pollution Research International
Sandya Chirukandath Jayasankaran, Prameela Govindalayathil Chelakkot, Milind Karippaliyil, Krishnakumar Thankappan, Subramaniya Iyer, Srikanth Moorthy
INTRODUCTION: Preoperative imaging is mandatory for deciding the extent of surgery in tumors of oral tongue. Previous studies have shown the significance of depth of tumor invasion in predicting nodal involvement. AIM: This prospective study aimed to assess the correlation between tumor dimensions in all three planes obtained through preoperative imaging and histopathological findings, as well as the correlation between these and pathological node positivity. MATERIALS AND METHODS: Fifty-nine consecutive patients with nonmetastatic, operable, squamous cell carcinoma of anterior two-thirds of the tongue were included in the study...
July 2017: Indian Journal of Cancer
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