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Tongue squamous Cell carcinoma

Scott E Janus, Taishi Hirai, Verghese Mathew, Mark Rabbat
Orthostatic hypotension has a vast differential that has been previously described throughout the literature. However, baroreceptor failure as a sequela of head and neck radiation is not often recognised as an important cause of dramatic haemodynamic variability. As a result, individuals suffering from baroreceptor failure likely have been undertreated. Herein, we report a case of a patient with a history of radiation to the neck for squamous cell carcinoma of the tongue and resultant baroreceptor failure resulting in syncope...
October 11, 2017: BMJ Case Reports
C M Glastonbury, S K Mukherji, B O'Sullivan, W M Lydiatt
The updated eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus-related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(-) oropharyngeal squamous cell carcinoma...
October 12, 2017: AJNR. American Journal of Neuroradiology
Juscelino Freitas Jardim, Rogério Gondak, Marisol Miranda Galvis, Clovis Antonio Lopes Pinto, Luiz Paulo Kowalski
BACKGROUND: Dendritic cells (DCs) are known to play a central role in the regulation of both innate and adaptive immunologic responses, including antitumor immunity. This study aimed to evaluate the prognostic impact of intra and peritumoral dendritic cells in oral squamous cell carcinoma (OSCC) affecting tongue and floor of the mouth. PATIENTS AND METHODS: Immunohistochemical reactions for CD1a and CD83 were performed in 53 patients with OSCC in tongue and floor of the mouth...
October 11, 2017: Histopathology
Prekshi Chaudhary, Sweety Gupta, Nitin Leekha, Ravi S Rajendra, Shiv S Mishra, Vandana Arora, Sudarsan De, Sandeep Agarwal
INTRODUCTION: Whole body PET CT is an important investigation tool in malignancy patients and helps in ascertaining the metabolic activity and exact stage of the disease. However, like any other investigation, false positive results do exist and certain diseases other than cancer may show increased uptake. Hence, a careful evaluation of PET CT and clinical correlation in malignancy patients is a must to accomplish the suitable treatment. METHODS: In this retrospective observational study, seven cases of cancer with concomitant tuberculosis were included...
September 2017: Gulf Journal of Oncology
Gülistan Karadeniz, Zehra Yaşar, Fatma Üçsular, Gülcan Ürpek, Melih Büyükşirin
Persence of multipl primary tumors in an organism is called as multiple primary cancer (MPC). Multipl tumors that occur at the same time are synchronized tumors, while those occuring at the different times called metachronous. MPCs are very rare entities. Here in we report a 96-year-old man who presented with synchronous MPC including squamous cell Lung cancer and tongue adenoid cystic carcinoma.
June 2017: Tüberküloz Ve Toraks
Xiaolong Cheng, Zhenli Hu, Yipin Han, Chong Bai
RATIONALE: Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor. PATIENT CONCERS: A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis. DIAGNOSES: A case of lung squamous cell carcinoma that metastasized to the base of a patient's tongue. INTERVATIONS: We send the biopsy of the lung and the tongue lesions for gene sequencing...
October 2017: Medicine (Baltimore)
Anders Näsman, Cinzia Bersani, David Lindquist, Juan DU, Torbjörn Ramqvist, Tina Dalianis
Human papillomavirus (HPV)-positive tonsillar- and base of tongue cancer is increasing epidemically and has much better outcome than corresponding HPV-negative cancer and most other head and neck cancers with around 80% 3-year disease free survival with conventional radiotherapy and surgery. Consequently, most HPV-positive cancer patients may not require the intensified chemoradiotherapy given to many head and neck cancer patients and would, with tapered treatment, avoid several severe side-effects. Moreover, intensified therapy has not improved survival and treatment alternatives are needed...
October 2017: Anticancer Research
Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Mai Hazekawa, Atsushi Yasukochi, Takuya Nishinakagawa, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima
Oral squamous cell carcinoma (OSCC) constitutes over 90% of all cancers in the oral cavity. The prognosis for patients with invasive OSCC is poor; therefore, it is important to understand the molecular mechanisms of invasion and subsequent metastasis not only to prevent cancer progression but also to detect new therapeutic targets against OSCC. Recently, extracellular vesicles-particularly exosomes-have been recognized as intercellular communicators in the tumor microenvironment. As exosomic cargo, deregulated microRNAs (miRNAs) can shape the surrounding microenvironment in a cancer-dependent manner...
October 5, 2017: Molecular Carcinogenesis
Yurong Kou, Tengfei Zhao, Shaohui Huang, Jie Liu, Weiyi Duan, Yunjing Wang, Zechen Wang, Delong Li, Chunliu Ning, Changfu Sun
PURPOSE: The aim of this study was to clarify whether level IIb dissection should be performed or avoided in the treatment of oral squamous cell carcinoma by meta-analysis. MATERIALS AND METHODS: Articles that were published before June 2017 were searched electronically in four databases (Web of Science, PubMed, Ovid and China National Knowledge Infrastructure) without any date or language restrictions by two independent reviewers. Abstracts and full-text papers which investigated the cervical metastases to level IIb from primary head and neck cancers and were deemed potentially relevant were screened...
2017: OncoTargets and Therapy
Wei Wang, Qianting He, Jingjing Sun, Zhonghua Liu, Luodan Zhao, Zhiyuan Lu, Xiaofeng Zhou, Anxun Wang
Pyruvate kinase M2 (PKM2) has been verified to correlate with the prognosis of many types of cancer. However, its role in the development and metastasis of tongue squamous cell carcinoma (TSCC) remains unclear. The immunohistochemistry (IHC) results confirmed that PKM2 is overexpressed in patients with TSCC. PKM2 up-regulation was related to lymph node metastasis and associated with reduced overall survival. According to the microarray analysis and Western blots, PKM2 expression was up-regulated in TSCC cells with enhanced metastatic potential...
September 15, 2017: Oncotarget
Tomohiro Enokida, Satoshi Fujii, Mari Takahashi, Youichi Higuchi, Shogo Nomura, Tetsuro Wakasugi, Tomoko Yamazaki, Ryuichi Hayashi, Atsushi Ohtsu, Makoto Tahara
OBJECTIVES: To establish a prognostic signature for locally advanced tongue squamous cell carcinoma (TSCC) patients treated with surgery. RESULTS: In the discovery study, unsupervised hierarchical clustering analysis identified two clusters which differentiated the Kaplan-Meier curves of RFS [median RFS, 111 days vs. not reached; log-rank test, P = 0.023]. The 30 genes identified were combined into a dichotomous PI. In the validation cohort, classification according to the PI was associated with RFS [median RFS, 754 days vs...
September 22, 2017: Oncotarget
G J Hanna, S-B Woo, Y Y Li, J A Barletta, P S Hammerman, J H Lorch
Young patients with oral cavity squamous cell carcinoma (OCSCC) are often recognized as a distinct epidemiological cohort. In this study, genomic and immune-based metrics were correlated with long-term outcomes for a young patient population treated at a single institution. A fully clinically annotated, retrospective cohort of 81 patients aged ≤45 years with OCSCC is described, and the impact of clinicopathological features on long-term survival outcomes is reported. Genomic and immune parameters were integrated utilizing a whole-exome sequencing and immunohistochemical approach among females in the cohort...
September 29, 2017: International Journal of Oral and Maxillofacial Surgery
Ioanna-Eirini Arvanitidou, Nikolaos G Nikitakis, Maria Georgaki, Nick Papadogeorgakis, Athanasios Tzioufas, Alexandra Sklavounou
Squamous cell carcinoma (SCC) developing in lesions of discoid lupus erythematosus (DLE) is rare, most frequently arising on sun-exposed skin and very rarely affecting the lips. A review of the English language literature revealed only 21 published cases of labial SCC in patients with DLE. Here, an unusual case of a patient with DLE who developed 3 primary SCCs of the oral and perioral region is presented. A 40-year-old female with a 24-year history of DLE with peri- and intraoral involvement initially developed SCC of the vermillion border of the right lower lip; the lesion was surgically removed and did not recur within 6 months...
August 30, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
A W Barrett, J V Tighe, A Gulati, L Newman, P M Norris, B S Bisase, M K Nicholls
Our aim was to find out first whether the extrinsic muscles of the tongue are histologically identifiable, and secondly to what degree the use of the new criteria in the 8th editions of the American Joint Committee on Cancer(AJCC)/Union for International Cancer Control (UICC) manuals (which have recognised the importance of depth of invasion of tumour, rather than invasion of the extrinsic muscles of the tongue and extranodal extension), will alter staging of lingual squamous cell carcinoma (SCC). The histological sections from 165 patients who had had primary resection of lingual SCC were reviewed, and one or more extrinsic muscles of the tongue was identified in 100 patients (61%), with the genioglossus seen the most often (in 96)...
September 27, 2017: British Journal of Oral & Maxillofacial Surgery
Masanari G Kato, Mark A Ellis, Shaun A Nguyen, Terry A Day
BACKGROUND: Oropharyngeal squamous cell carcinoma (SCC) frequently presents with cervical metastasis. Roles of human papillomavirus (HPV) status, among other factors, on laterality are elusive. METHODS: The National Cancer Database was reviewed for oropharyngeal SCC diagnosed from 2010-2014. Predictors of clinically evident contralateral or bilateral nodal disease were identified. RESULTS: A total of 15 517 patients with oropharyngeal SCC met criteria...
September 30, 2017: Head & Neck
Yujia Wang, Sheng Chen, Yanhong Ni, Derek Magee, Yumei Pu, Qian Zhou, Zhiyong Wang, Lei Zhang, Xiaofeng Huang, Qingang Hu
OBJECTIVES: Margin status and invasion pattern are prognostic factors for oral tongue squamous cell carcinoma (OTSCC). Current methods to identify these factors are limited to 2D observation, it is necessary to explore 3D reconstruction with whole-mount sample to improve analysis accuracy. This study aimed to study the tissue-preparation, section generation and 3D reconstruction with whole-mount OTSCC specimen. STUDY DESIGN: Two OTSCC samples were retrieved from Nanjing Stomatological Hospital, Medical School of Nanjing University...
September 28, 2017: Journal of Oral Pathology & Medicine
Elham Mohebbi, Zahra Noormohamadi, Habib Sadeghi Rad, Farzin Sadeghi, Yousef Yahyapour, Farzam Vaziri, Ayoub Rahimi, Fatemeh Rahimi Jamnani, Saman Mehrabi, Seyed Davar Siadat, Mohammad Reza Noori-Daloii, Abolfazl Fateh
Recent studies show that the human Merkel cell polyomavirus (MCPyV) may be involved in causing cancer. The objective of this study was to assess the impact of MCPyV on the development of head and neck squamous cell carcinoma (HNSCC). Totally, 50 paraffin-embedded HNSCC biopsy samples and 50 adjacent non-cancerous samples were evaluated for the presence of MCPyV DNA and RNA. Among patients, the five most frequent histopathologic sites were the tongue (22.0%), lip (16.0%), submandibular (14.0%), cheek (14.0%), and throat (14...
September 28, 2017: Journal of Medical Virology
Bruna Dos Santos Mendonça, Michelle Agostini, Iara Gonçalves Aquino, Wagner Barbosa Dias, Débora Campanella Bastos, Franklin D Rumjanek
MAGE-A10 is a member of the MAGE protein family (melanoma associated antigen) which is overexpressed in cancer cells. Although MAGE-A10 has been characterized for some time and is generally associated to metastasis its function remains unknown. Here we describe experiments using as models oral squamous cell carcinoma (OSCC) cell lines displaying increasing metastatic potential (LN1 and LN2). These cell lines were transduced with lentivirus particles coding for short hairpin against MAGE-A10 mRNA. Repression of MAGE-A10 expression in LN2 cells altered their morphology and impaired growth of LN1 and LN2 cell lines...
July 2017: Biochemistry and Biophysics Reports
Ahmed Al-Samadi, Shady Adnan Awad, Katja Tuomainen, Yue Zhao, Abdelhakim Salem, Mataleena Parikka, Tuula Salo
The crosstalk between immune cells, cancer cells, and extracellular vesicles (EVs) secreted by cancer cells remains poorly understood. We created three-dimensional (3D) cell culture models using human leiomyoma discs and Myogel to study the effects of immune cells on highly (HSC-3) and less (SCC-25) invasive oral tongue squamous cell carcinoma (OTSCC) cell lines. Additionally, we studied the effects of EVs isolated from these cell lines on the cytotoxicity of CD8(+) T and NK cells isolated from three healthy donors...
September 1, 2017: Oncotarget
Takahiko Shibahara
Oral cancer is a malignant neoplasm that occurs in the oral cavity. Squamous cell carcinoma accounts for over 90%of the oral cancers, and others include adenocarcinoma derived from minor salivary gland, sarcoma, malignant lymphoma and metastatic cancer. The number of oral cancer patients in Japan is about 3-times higher than the current number. Age-adjusted male-to-female ratio is 3:2, which is higher in males than in females. Of oral cancers, tongue carcinomas accounts is the most common and accounts for 40%of oral cancers...
2017: Clinical Calcium
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