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Tongue squamous Cell carcinoma

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https://www.readbyqxmd.com/read/28440859/sonographic-detection-of-a-lingual-node-metastasis-from-early-squamous-cell-cancer-of-the-tongue
#1
Naoki Nishio, Yasushi Fujimoto, Mariko Hiramatsu, Yoko Yamamoto, Michihiko Sone
Lingual node metastasis from early-stage squamous cell carcinoma of the tongue is uncommon and difficult to detect. We present a case of a lingual lymph node metastasis from an early tongue cancer. Sonography demonstrated a small nonpalpable lingual node on the floor of the mouth. The patient underwent complete surgical resection and had no evidence of recurrence 5 years later. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound, 2017.
April 25, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28439324/contemporary-diagnostic-imaging-of-oral-squamous-cell-carcinoma-a-review-of-literature
#2
REVIEW
Paulina Pałasz, Łukasz Adamski, Magdalena Górska-Chrząstek, Anna Starzyńska, Michał Studniarek
Oral squamous cell carcinoma (OSCC) is the most common cancer of the oral cavity and constitutes 95% of all cancers of this area. Men are affected twice as commonly as women, primarily if they are over 50 years of age. Forty percent of the lesions are localized in the tongue and 30% in the floor of the oral cavity. OSCC often affects upper and lower gingiva, buccal mucous membrane, the retromolar triangle and the palate. The prognosis is poor and the five-year survival rate ranges from 20% (OSCC in the floor of the mouth) to 60% (OSCC in the alveolar part of the mandible)...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28435450/exome-sequencing-of-oral-squamous-cell-carcinoma-reveals-molecular-subgroups-and-novel-therapeutic-opportunities
#3
Shih-Chi Su, Chiao-Wen Lin, Yu-Fan Liu, Wen-Lang Fan, Mu-Kuan Chen, Chun-Ping Yu, Wei-En Yang, Chun-Wen Su, Chun-Yi Chuang, Wen-Hsiung Li, Wen-Hung Chung, Shun-Fa Yang
Oral squamous cell carcinoma (OSCC), an epithelial malignancy affecting a variety of subsites in the oral cavity, is prevalent in Asia. The survival rate of OSCC patients has not improved over the past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes. Improvement in therapeutic strategies and tailored treatment options is an unmet need. To unveil the mutational spectrum, whole-exome sequencing of 120 OSCC from male individuals in Taiwan was conducted. Analyzing the contributions of the five mutational signatures extracted from the dataset of somatic variations identified four groups of tumors that were significantly associated with demographic and clinical features...
2017: Theranostics
https://www.readbyqxmd.com/read/28434836/retrograde-superselective-intra-arterial-chemotherapy-and-daily-concurrent-radiotherapy-for-t2-4n0-tongue-cancer-control-of-occult-neck-metastasis
#4
Shuhei Minamiyama, Kenji Mitsudo, Yuichiro Hayashi, Masaki Iida, Toshinori Iwai, Hideyuki Nakashima, Senri Oguri, Tomomichi Ozawa, Toshiyuki Koizumi, Makoto Hirota, Mitomu Kioi, Iwai Tohnai
OBJECTIVE: To evaluate the therapeutic results and control of occult neck metastasis in patients with T2-4N0 oral tongue squamous cell carcinoma treated with retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy. STUDY DESIGN: Forty-two patients with T2-4N0 tongue cancer (17 with late T2; 13 with T3; and 12 with T4a disease, M0) were treated with intra-arterial chemoradiotherapy. Treatment consisted of retrograde superselective intra-arterial chemotherapy (docetaxel 50-70 mg/m(2), cisplatin 125-175 mg/m(2)) and daily concurrent radiotherapy (50-70 Gy) for 5-7 weeks...
February 21, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28433834/antimicrobial-and-anticancer-photodynamic-activity-of-a-phthalocyanine-photosensitizer-with-n-methyl-morpholiniumethoxy-substituents-in-non-peripheral-positions
#5
Jolanta Dlugaszewska, Wojciech Szczolko, Tomasz Koczorowski, Paulina Skupin-Mrugalska, Anna Teubert, Krystyna Konopka, Malgorzata Kucinska, Marek Murias, Nejat Düzgüneş, Jadwiga Mielcarek, Tomasz Goslinski
Photodynamic therapy involves the use of a photosensitizer that is irradiated with visible light in the presence of oxygen, resulting in the formation of reactive oxygen species. A novel phthalocyanine derivative, the quaternary iodide salt of magnesium(II) phthalocyanine with N-methyl morpholiniumethoxy substituents, was synthesized, and characterized. The techniques used included mass spectrometry (MALDI TOF), UV-vis, NMR spectroscopy, and photocytotoxicity against bacteria, fungi and cancer cells. The phthalocyanine derivative possessed typical characteristics of compounds of the phthalocyanine family but the effect of quaternization was observed on the optical properties, especially in terms of absorption efficiency...
April 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28413152/loss-of-pten-expression-is-associated-with-high-microrna-24-level-and-poor-prognosis-in-patients-with-tongue-squamous-cell-carcinoma
#6
Jingzhu Zhao, Jiadong Chi, Ming Gao, Jingtai Zhi, Yigong Li, Xiangqian Zheng
PURPOSE: The aim of this study was to detect the relationship between phosphatase and tensin homolog deletion on chromosome 10 (PTEN) and microRNA 24 (miR-24) and correlate PTEN expression with important clinical parameters of patients with tongue squamous cell carcinoma (TSCC). MATERIALS AND METHODS: In this retrospective case series, all TSCC patients treated at Tianjin Medical University Cancer Institute and Hospital between March 2005 and October 2011 were retrospectively reviewed...
March 23, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28411370/nomograms-to-estimate-long-term-overall-survival-and-tongue-cancer-specific-survival-of-patients-with-tongue-squamous-cell-carcinoma
#7
Yun Li, Zhenyan Zhao, Xiaoxiao Liu, Jun Ju, Juan Chai, Qianwei Ni, Chao Ma, Tao Gao, Moyi Sun
The aim of this study was to construct nomograms to predict long-term overall survival (OS) and tongue cancer-specific survival (TCSS) of tongue squamous cell carcinoma (TSCC) patients based on clinical and tumor characteristics. Clinical, tumor, and treatment characteristics of 12,674 patients diagnosed with TSCC between 2004 and 2013 were collected from the Surveillance, Epidemiology, and End Results database. These patients were then divided into surgery and nonsurgery cohorts, and nomograms were developed for each of these groups...
April 14, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28403069/using-a-pedicle-pectoralis-major-musculocutaneous-flap-in-head-and-neck-reconstruction-after-modified-radical-mastectomy-a-case-report
#8
Jen-Wu Huang, Nai-Yuan Wu, Yi-Ying Lin
RATIONALE: A pedicle pectoralis major musculocutaneous (PMMC) flap is one of the strategies for head and neck reconstruction. Seldom studies reported the case in which the skin area of previous modified radical mastectomy (MRM) had been used as a PMMC flap in head and neck reconstruction. PATIENT CONCERNS: An 84-year-old female who had suffered from left breast cancer and undergone a left modified radical mastectomy (MRM) more than 20 years earlier. DIAGNOSES: She had squamous cell carcinoma of the tongue and had undergone partial glossection and left modified radial neck dissection...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28399391/cd163-positive-macrophages-within-the-tumor-stroma-are-associated-with-lymphangiogenesis-and-lymph-node-metastasis-in-oral-squamous-cell-carcinoma
#9
Yuko Yamagata, Hirofumi Tomioka, Kei Sakamoto, Kiyoshi Sato, Hiroyuki Harada, Tohru Ikeda, Kou Kayamori
PURPOSE: Increasing evidence shows that tumor stromal components, particularly tumor-associated macrophages (TAMs), play an important role in the tumor progression of various solid malignant tumor types. However, their roles in oral squamous cell carcinoma (OSCC) have not been fully elucidated. MATERIALS AND METHODS: Seventy human tongue OSCC samples were analyzed in the present study. Immunohistochemistry was used to investigate the correlations between the densities of CD68-, CD163-, and CD204-positive TAMs and clinicopathologic parameters...
March 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28397948/retrospective-analysis-of-biopsied-oral-and-maxillofacial-lesions-in-south-western-saudi-arabia
#10
Sanaa M Saleh, Ali M Idris, Nandimandalam V Vani, Faisal M Tubaigy, Fahd A Alharbi, Abubakr A Sharwani, Nabil T Mikhail, Saman Warnakulasuriya
To report the prevalence and types of biopsied oral and maxillofacial lesions (OMLs) in South-Western (Jazan Province) region, , Kingdom of Saudi Arabia (KSA). Methods: This retrospective study was based on the retrieval of clinicopathological data for a period of 6 years between January 2009 and December 2014. These  data were obtained between October 2014 and June 2015 from the histopathology records of King Fahad Central Hospital, Jazan, KSA, which is the only referral center for biopsy services. Results: Out of the 32149 biopsies received, 714 (2...
April 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28393404/patients-with-high-c-myc-expressing-squamous-cell-carcinomas-of-the-tongue-show-better-survival-than-those-with-low-and-medium-expressing-tumours
#11
Klas Strindlund, Giuseppe Troiano, Nicola Sgaramella, Philip J Coates, Xiaolian Gu, Linda Boldrup, Luigi Califano, Robin Fahraeus, Lorenzo Lo Muzio, Fatima Ardito, Giuseppe Colella, Gianpaolo Tartaro, Renato Franco, Lena Norberg-Spaak, Mohammad Saadat, Karin Nylander
BACKGROUND: c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. METHODS: Immunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein...
April 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28390748/effectiveness-of-radiotherapy-ozone-on-tumoral-tissue-and-survival-in-tongue-cancer-rat-model
#12
Remzi Dogan, Aysenur Meric Hafız, Huriye Senay Kiziltan, Alper Yenigun, Nur Buyukpinarbaslili, Ali Hikmet Eris, Orhan Ozturan
OBJECTIVE: The objective of this study is to examine therapeutic effect of the combination of radiotherapy and ozone which features increasing of the destruction of cancer cells by increasing oxygen level of the body on advanced tongue cancer induced in rats. METHODS: A total of 36 female rats were included in this study as 4 groups. Group 1 (Cancer, n=8): 4NQO. Group 2 (Cancer+Radiotherapy, n=10): 4NQO+Radiotherapy. Group 3 (Cancer+Ozone+Radiotherapy, n=10): 4NQO+Ozone+Radiotherapy...
April 5, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28374102/predictive-significance-of-tumor-depth-and-budding-for-late-lymph-node-metastases-in-patients-with-clinical-n0-early-oral-tongue-carcinoma
#13
Yukiko Hori, Akira Kubota, Tomoyuki Yokose, Madoka Furukawa, Takeshi Matsushita, Morihito Takita, Sachiyo Mitsunaga, Nobutaka Mizoguchi, Tetsuo Nonaka, Yuko Nakayama, Nobuhiko Oridate
In clinical N0 early oral tongue carcinoma, treatment of occult lymph node metastasis is controversial. The purpose of this study was to assess the histopathological risk factors for predicting late lymph node metastasis in early oral tongue carcinoma. We retrospectively reviewed 48 patients with early oral tongue squamous cell carcinoma. Associations between the histopathological factors (depth of tumor, differentiation, blood vessel invasion, lymphatic invasion, and tumor budding) and late lymph metastasis were analyzed...
April 3, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28367232/upregulated-long-non-coding-rna-linc00152-expression-is-associated-with-progression-and-poor-prognosis-of-tongue-squamous-cell-carcinoma
#14
Jianjun Yu, Yan Liu, Can Guo, Shanshan Zhang, Zhaojian Gong, Yanyan Tang, Liting Yang, Yi He, Yu Lian, Xiayu Li, Hao Deng, Qianjin Liao, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong, Xinming Yang
Altered expression of long non-coding RNAs (lncRNAs) associated with human carcinogenesis and might be used as diagnosis and prognosis biomarkers. However, the expression of lncRNAs in tongue squamous cell carcinoma (TSCC) and their relevance on the diagnosis, progression and prognosis of TSCC have not been thoroughly elucidated. To discover novel TSCC-related lncRNAs, we analyzed the lncRNA expression patterns in two sets of previously published TSCC gene expression profile data (GSE30784 and GSE9844), and found that long intergenic non-coding RNA 152 (LINC00152) was significantly upregulated in TSCC samples...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28363091/corrigendum-to-afm-nanoindentation-detection-of-the-elastic-modulus-of-tongue-squamous-carcinoma-cells-with-different-metastatic-potentials-nanomedicine-9-2013-864-874
#15
Zhuolong Zhou, Chaoxu Zheng, Su Li, Xiaofeng Zhou, Zhonghua Liu, Qianting He, Ningning Zhang, Alfonso Ngan, Bin Tang, Anxun Wang
No abstract text is available yet for this article.
March 28, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28361597/regional-recurrence-in-early-stage-i-ii-oral-tongue-cancer-a-single-institutional-study-and-review-of-the-literature
#16
Alexander Kamali, Caroline Gahm, Björn Palmgren, Linda Marklund, Martin Halle, Lalle Hammarstedt-Nordenvall
CONCLUSIONS: There is a high propensity for locoregional and isolated regional failure in stage II patients, even though treated with combined therapy. In stage I patients the risk of isolated regional failure was moderate, at levels below 10%. BACKGROUND: The neck treatment of early stages of oral tongue squamous cell carcinoma (OTSCC) are still debatable, considering that previous studies have produced diverting results. The purpose of this study is to report on the outcome of patients with stages I-II, with special respect to regional outcome...
February 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28357642/genome-wide-gene-expression-profiling-of-tongue-squamous-cell-carcinoma-by-rna-seq
#17
Hai Xia Zhang, Ou Sheng Liu, Chao Deng, Yan He, Ye Qian Feng, Jin An Ma, Chun Hong Hu, Zhan Gui Tang
OBJECTIVE: Tongue squamous cell carcinoma (TSCC) is significantly more malignant than other type of oral squamous cell carcinoma (OSCC). In this study, we aimed to identify specific global gene expression signatures of TSCC to investigate the more invasive behavior of the deeply infiltrating cancer. METHODS: Using RNA-seq technology, we detected gene expression of 20 TSCCs, 20 matched paratumor tissues, and 10 healthy normal mucosa tissues. Enrichment analysis of gene ontology (GO) and pathway was conducted using online tools DAVID for the dysregulated genes...
March 29, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28357090/raynaud-s-of-the-tongue-following-chemoradiation-for-squamous-cell-carcinoma-of-the-oropharynx
#18
Amit Mittal, Bharat B Mittal
Raynaud's of the tongue following radiation alone or chemoradiotherapy (CRT) is a rare occurrence. The present study reports a case where typical symptoms and signs of Raynaud's phenomenon involving the tongue occurred ~18 months following CRT treatment in a 53-year-old female, who was a smoker prior to CRT with stage T2N2cM0 local-regional advanced stage IV oropharyngeal cancer. The patient was treated using cisplatin chemotherapy and intensity-modulated radiation with a dose of 70 Gray (Gy). The intermittent episodes of painful discoloration of the tongue were exacerbated due to the cold and emotional stress...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28356969/microrna-149-targets-specificity-protein-1-to-suppress-human-tongue-squamous-cell-carcinoma-cell-proliferation-and-motility
#19
Jingxin Chen, Jimin Chen, Weizhong Li
The expression and function of microRNA-149 have been studied in numerous types of cancer. However, thus far, there are no studies of microRNA-149 in tongue squamous cell carcinoma (TSCC). The present study investigated the expression, biological function and molecular mechanism of microRNA-149 in TSCC in vitro, discussing whether it may be a therapeutic biomarker of TSCC in the future. In the present study, microRNA-149 expression in TSCC tissues, matched normal adjacent tissues, TSCC cell lines and normal gingival epithelial cells were analyzed using quantitative polymerase chain reaction...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28356689/an-epidemiological-survey-in-hospital-setup-in-lucknow-district-a-cross-sectional-study
#20
Uma Shanker Pal, Mayank Singh, Lakshya Kumar, Pankaj Verma, R K Singh, Shailendra Kumar, G G Agarwal, Akash Asthana
INTRODUCTION: Oral cancer is the sixth most common form of cancer reported globally which includes lip, tongue, mouth, and throat. Developing countries face several challenges to identify and remove potential risk factors. Chewing tobacco/pan masala is considered to be the most potential risk factor for oral precancerous lesions and oral cancer. OBJECTIVE: To study the clinical-epidemiological profile of oral cancer cases and potential risk factor associated with it...
July 2016: National Journal of Maxillofacial Surgery
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