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stable coronary artery disease

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https://www.readbyqxmd.com/read/29451512/-antegrade-and-retrograde-approach-through-the-venous-graft-for-treating-a-chronic-total-occlusion-in-a-patient-with-acute-coronary-syndrome-complicated-by-pulmonary-edema
#1
Francesco Gallo, Matteo Tebaldi, Carlo Tumscitz
Percutaneous treatment of chronic total occlusions (CTO) is one of the major challenges in contemporary interventional cardiology. These lesions are identified in 15% to 30% of all patients referred for coronary angiography. Percutaneous coronary intervention (PCI) of CTOs is technically challenging and requires familiarity with advanced interventional techniques as well as specialty equipment. The choice of strategy and materials is based on clinical features and coronary anatomy; the correct choice is essential to improve the success probability...
January 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29450765/impact-of-platelet-reactivity-on-5-year-clinical-outcomes-following-percutaneous-coronary-intervention-a-landmark-analysis
#2
Fabio Mangiacapra, Iginio Colaiori, Elisabetta Ricottini, Antonio Creta, Giuseppe Di Gioia, Ilaria Cavallari, Edoardo Bressi, Marialessia Capuano, Emanuele Barbato, Germano Di Sciascio
We investigated the impact of suboptimal platelet reactivity on clinical outcomes after percutaneous coronary intervention (PCI). We enrolled 500 patients with stable coronary artery disease undergoing elective PCI. Platelet reactivity was measured before PCI using the VerifyNow P2Y12 assay. Primary endpoint was the incidence of ischemic or bleeding events at 1 month and 5 years. Patients with high platelet reactivity (HPR) showed significantly higher rates of ischemic events both during the 1st month after PCI (HR 2...
February 15, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29449442/design-and-rationale-of-the-ripcord-2-trial-does-routine-pressure-wire-assessment-influence-management-strategy-at-coronary-angiography-for-diagnosis-of-chest-pain-a-randomized-controlled-trial-to-compare-routine-pressure-wire-assessment-with-conventional-angiography
#3
REVIEW
Mostafa Elguindy, Rod Stables, Zoe Nicholas, Ian Kemp, Nick Curzen
BACKGROUND: Investigation of anginal chest pain has traditionally involved either assessment of the coronary anatomy by angiography or noninvasive testing for reversible ischemia. Invasive pressure wire assessment at the time of angiography offers information on both anatomy and physiology. Fractional flow reserve-guided percutaneous coronary intervention is associated with lower resource utilization and improved clinical outcome compared with angiographic guidance alone. However, the value of routine fractional flow reserve of all major coronary vessels at the time of diagnostic angiography has not been established in a randomized trial despite persuasive observational data...
February 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29447788/the-influence-of-febuxostat-on-coronary-artery-endothelial-dysfunction-in-patients-with-coronary-artery-disease-a-phase-4-randomized-placebo-controlled-double-blind-crossover-trial
#4
Allison G Hays, Micaela Iantorno, Michael Schär, Shenghan Lai, Matthew Czarny, Elayne Breton, Robert N Palmer, Andrew Whelton, Robert G Weiss, Gary Gerstenblith
BACKGROUND: The xanthine oxidase (XO) system is a significant source of vascular oxidative stress, which is believed to impair endothelial function, an important contributor to atherosclerotic disease. We tested whether febuxostat, a potent XO inhibitor, improves coronary endothelial function (CEF) in patients with stable coronary artery disease (CAD) in a single-center, randomized, placebo-controlled, double-blind crossover trial. METHODS: CEF was measured using noninvasive magnetic resonance imaging (MRI) assessment of changes in 30 patients with stable CAD and baseline impaired CEF...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29446126/layer-specific-global-longitudinal-strain-reveals-impaired-cardiac-function-in-patients-with-reversible-ischemia
#5
Christoffer E Hagemann, Søren Hoffmann, Flemming J Olsen, Peter G Jørgensen, Thomas Fritz-Hansen, Jan S Jensen, Tor Biering-Sørensen
AIMS: Two-dimensional speckle tracking echocardiography (2DSTE) detects early signs of left ventricular dysfunction; however, it is unknown whether layer-specific global longitudinal strain (GLS) has incremental value in diagnosis of patients with reversible ischemia assessed by single photon emission computed tomography (SPECT). METHODS AND RESULTS: Eighty patients with stable angina pectoris (SAP), normal left ventricular ejection fraction (LVEF), and no history of ischemic heart disease were retrospectively identified to have been examined by 2DSTE, SPECT, and coronary angiography (CAG)...
February 15, 2018: Echocardiography
https://www.readbyqxmd.com/read/29446055/which-costs-matter-costs-included-in-economic-evaluation-and-their-impact-on-decision-uncertainty-for-stable-coronary-artery-disease
#6
James Lomas, Miqdad Asaria, Laura Bojke, Chris P Gale, Gerry Richardson, Simon Walker
BACKGROUND: Variation exists in the resource categories included in economic evaluations, and National Institute for Health and Care Excellence (NICE) guidance suggests the inclusion only of costs related to the index condition or intervention. However, there is a growing consensus that all healthcare costs should be included in economic evaluations for Health Technology Assessments (HTAs), particularly those related to extended years of life. OBJECTIVE AND METHODS: We aimed to quantify the impact of a range of cost categories on the adoption decision about a hypothetical intervention, and uncertainty around that decision, for stable coronary artery disease (SCAD) based on a dataset comprising 94,966 patients...
February 14, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29444926/high-sensitivity-cardiac-troponin-i-and-the-diagnosis-of-coronary-artery-disease-in-patients-with-suspected-angina-pectoris
#7
Philip D Adamson, Amanda Hunter, Debbie M Madsen, Anoop S V Shah, David A McAllister, Tania A Pawade, Michelle C Williams, Colin Berry, Nicholas A Boon, Marcus Flather, John Forbes, Scott McLean, Giles Roditi, Adam D Timmis, Edwin J R van Beek, Marc R Dweck, Hans Mickley, Nicholas L Mills, David E Newby
BACKGROUND: We determined whether high-sensitivity cardiac troponin I can improve the estimation of the pretest probability for obstructive coronary artery disease (CAD) in patients with suspected stable angina. METHODS AND RESULTS: In a prespecified substudy of the SCOT-HEART trial (Scottish Computed Tomography of the Heart), plasma cardiac troponin was measured using a high-sensitivity single-molecule counting assay in 943 adults with suspected stable angina who had undergone coronary computed tomographic angiography...
February 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29443740/clinical-outcomes-of-left-main-coronary-artery-disease-patients-undergoing-three-different-revascularization-approaches
#8
Chieh-Shou Su, Yu-Wei Chen, Ching-Hui Shen, Tsun-Jui Liu, Yen Chang, Wen-Lieng Lee
Significant unprotected left main (LM) coronary artery disease is frequently associated with severe multivessel disease and increased mortality and morbidity compared with non-LM coronary artery disease. This study compared the clinical outcomes of patients with LM disease who received percutaneous coronary intervention (PCI) with stenting, conventional coronary-artery bypass grafting (C-CABG), and robot-assisted CABG (R-CABG).This retrospective study analyzed 472 consecutive LM disease patients who underwent three different revascularization approaches at a tertiary medical center between January 2005 and November 2013...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29434690/changes-in-inflammatory-factors-and-prognosis-of-patients-complicated-with-non-alcoholic-fatty-liver-disease-undergoing-coronary-artery-bypass-grafting
#9
Lei Wang, Yuanming Li, Xiaojin Gong
This study was designed to assess the relationship between changes in peripheral inflammatory factors of patients complicated with non-alcoholic fatty liver disease (NAFLD) undergoing coronary artery bypass grafting (CABG) before and after operation, and their prognosis. A total of 68 patients with stable angina pectoris treated in Xinjiang Hospital who underwent CABG at some point between August of 2013 and August of 2015 were enrolled in the study, and divided into the NAFLD group (n=31) and the non-NAFLD group (n=37) according to the presence of the condition or its absence...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434623/chinese-expert-consensus-on-the-non-invasive-imaging-examination-pathways-of-stable-coronary-artery-disease
#10
Yun-Dai Chen, Wei-Yi Fang, Ji-Yan Chen, Zhan-Ming Fan, Chuan-Yu Gao, Jun-Bo Ge, Zuo-Xiang He, Yong Huo, Lang Li, Si-Jin Li, Xi-Lie Lu, Bin Lv, Ju-Ying Qian, Ya-Jun Shi, Zhu-Jun Shen, Jing Wang, Yi-Ning Wang, Lei Xu, Li Yang, Bo Yu, Mei Zhang, Jun-Jie Yang, Shu-Yang Zhang, Xiao-Li Zhang, Shi-Hua Zhao, Yang Zheng, Yu-Chi Han, Guang Zhi
No abstract text is available yet for this article.
January 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29434090/determinants-and-long-term-outcomes-of-percutaneous-coronary-interventions-vs-surgery-for-multivessel-disease-according-to-clinical-presentation
#11
Sung-Jin Hong, Byeong-Keuk Kim, Sanghoon Shin, Yongsung Suh, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
BACKGROUND: The long-term outcome of percutaneous coronary intervention (PCI) vs. coronary artery bypass graft (CABG), particularly for patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), remains controversial.Methods and Results:We retrospectively analyzed 2,827 patients (stable coronary artery disease [SCAD], n=1,601; NSTE-ACS, n=1,226) who underwent either PCI (n=1,732) or CABG (n=1,095). The 8-year composite of cardiac death and myocardial infarction (MI) was compared between PCI and CABG before and after propensity matching...
February 9, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29433015/effect-of-strenuous-exercise-on-mediators-of-inflammation-in-patients-with-coronary-artery-disease
#12
Joanna Cwikiel, Ingebjørg Seljeflot, Eivind Berge, Ida Unhammer Njerve, Hilde Ulsaker, Harald Arnesen, Arnljot Flaa
BACKGROUND: Coronary artery disease (CAD) is considered a low-grade inflammatory disease. We aimed to identify effects of short-term strenuous exercise on mediators of systemic inflammation, endothelial and platelet activation in patients with angiographically verified CAD. We hypothesized that a more pronounced inflammatory response would be present in patients with CAD than in those without CAD. METHODS: In subjects with symptoms indicative of stable CAD, an exercise stress test on a bicycle ergometer was performed...
February 9, 2018: Cytokine
https://www.readbyqxmd.com/read/29432398/ranolazine-treatment-in-the-heterogeneous-symptomatic-stable-coronary-artery-disease-population
#13
Mauro Borzi, Alfredo Intorcia, Marco A Perrone, Giulia Grilli, Domenico Sergi, Martina Borzi, Francesco Romeo
No abstract text is available yet for this article.
February 9, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29431415/stents-for-stable-coronary-artery-disease
#14
Andrew Apps, Aseem Malhotra
No abstract text is available yet for this article.
January 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29429843/invasive-in-the-cath-lab-assessment-of-myocardial-ischemia-in-patients-with-coronary-artery-disease-when-does-the-gold-standard-not-apply
#15
REVIEW
Stefano Benenati, Giovanni Luigi De Maria, Roberto Scarsini, Italo Porto, Adrian P Banning
International guidelines recommend that revascularization for coronary artery disease (CAD) should be guided by evidence of myocardial ischemia. Fractional flow reserve (FFR) and instantaneous free wave ratio (iFR) are the main invasive indices for assessing the ischemic potential of angiographically intermediate coronary stenosis as a large body of evidence supports their routine application. Both indices have been tested and validated in patients with isolated stable CAD, but notably their application outside this specific context is a matter of debate and investigation...
January 31, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29425088/pci-for-stable-angina-a-missed-opportunity-for-shared-decision-making
#16
REVIEW
Michael B Rothberg
Percutaneous coronary intervention (PCI) continues to be frequently performed for patients with stable coronary artery disease, despite clear evidence that it provides minimal benefit over optimal medical therapy and entails small but not inconsequential risks. Many patients and doctors do not fully understand the risks and benefits of PCI, even when presented with the evidence, and this makes informed consent challenging. The best approach is shared decision-making, with doctor and patient together choosing the best treatment option after considering the evidence and the patient's preferences...
February 2018: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29424731/efficacy-of-cardiac-shock-wave-therapy-in-patients-with-stable-angina-the-design-of-randomized-triple-blind-sham-procedure-controlled-study
#17
Evgeny Shkolnik, Greta Burneikaite, Jelena Celutkiene, Mikhail Scherbak, Gitana Zuoziene, Birute Petrauskiene, Ekaterina Trush, Aleksandras Laucevicius, Yury Vasyuk
OBJECTIVE: Despite revascularization and optimal medical treatment (OMT), patients with angina often have a reduced quality of life due to inadequate relief from symptoms. Recent studies have shown that the application of shock waves may reduce angina symptoms and improve quality of life, exercise capacity, and myocardial perfusion due to the stimulation of angiogenesis. However, there is limited evidence due to small, single-arm, single-center studies of low to moderate quality. The purpose of this study is to evaluate the impact of cardiac shock wave therapy (CSWT) on exercise tolerance and angina symptoms in patients with coronary artery disease and objective evidence of myocardial ischemia who cannot undergo traditional revascularization and experience angina despite OMT in comparison to sham procedure...
February 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29422264/perilipin-2-levels-are-increased-in-patients-with-in-stent-neoatherosclerosis-a-clue-to-mechanisms-of-accelerated-plaque-formation-after-drug-eluting-stent-implantation
#18
Giampaolo Niccoli, Domenico D'Amario, Josip A Borovac, Erminio Santangelo, Giancarla Scalone, Francesco Fracassi, Rocco Vergallo, Vincenzo Vetrugno, Giorgia Copponi, Anna Severino, Giovanna Liuzzo, Asiia Imaeva, Andrea Siracusano, Filippo Crea
BACKGROUND: Perilipin 2 (PLIN2) is a protein that potentially facilitates atherogenesis in native coronary arteries or arteries with an implanted drug-eluting stent (DES). The aim of the study was to determine PLIN2 protein levels in peripheral monocytes of enrolled subjects and compare them between patients with native coronary artery disease (CAD) and those with an in-stent restenosis (ISR) due to neoatherosclerosis occurring >1 year after DES implantation. METHODS: Forty-two patients were prospectively enrolled in the study in 3:1 fashion and underwent coronary catheterization...
February 5, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29422093/reduced-coronary-collateralization-in-type-2-diabetic-patients-with-chronic-total-occlusion
#19
REVIEW
Ying Shen, Feng Hua Ding, Yang Dai, Xiao Qun Wang, Rui Yan Zhang, Lin Lu, Wei Feng Shen
BACKGROUND: The extent of coronary collateral formation is a primary determinant of the severity of myocardial damage and mortality after coronary artery occlusion. Type 2 diabetes mellitus (T2DM) represents an important risk factor for impaired collateral vessel growth. However, the mechanism of reduced coronary collateralization in type 2 diabetic patients remains unclear. METHODS: With the reference to the recent researches, this review article describes the pathogenic effects of T2DM on collateral development and outlines possible clinical and biochemical markers associated with reduced coronary collateralization in type 2 diabetic patients with chronic total occlusion (CTO)...
February 8, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29421018/biomarkers-in-stable-coronary-artery-disease
#20
REVIEW
Cian P McCarthy, John W McEvoy, James L Januzzi
Coronary artery disease (CAD) remains a significant cause of morbidity and mortality around the world. Patients with stable CAD can have an unpredictable clinical trajectory; thus, additional tools to prognosticate risk in this cohort are warranted. In recent years, a wide range of biomarkers has been recognized for their diagnostic capabilities in patients with stable CAD, identifying those with obstructive disease who may require more intensive preventive therapies or even consideration of percutaneous coronary intervention in some circumstances...
February 2018: American Heart Journal
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