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https://www.readbyqxmd.com/read/29914299/elevated-oxidative-dna-damage-in-patients-with-coronary-artery-disease-and-its-association-with-oxidative-stress-biomarkers
#1
M A Bhat, G Gandhi
OBJECTIVE: The objective of the present study was to evaluate oxidative DNA damage in peripheral blood leukocytes (PBLs) of patients with coronary artery disease (CAD) and to explore the relationship of oxidised purine and pyrimidine with oxidative stress. METHODS: The study participants (n = 100) included 50 patients and unrelated 50 age-, sex- and population-subgroup (Jat Sikhs)-matched healthy controls. Oxidative DNA damage using the modified enzymatic comet in PBLs, and malondialdehyde (MDA) levels, total oxidant status (TOS) and total antioxidant status (TAS) in blood serum samples using spectrophotometric methods was determined...
June 18, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29912879/polyclonal-human-antibodies-against-glycans-bearing-red-meat-derived-non-human-sialic-acid-n-glycolylneuraminic-acid-are-stable-reproducible-complex-and-vary-between-individuals-total-antibody-levels-are-associated-with-colorectal-cancer-risk
#2
Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki
BACKGROUND: N-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first example of a "xeno-autoantigen", against which circulating human "xeno-autoantibodies" can react. The resulting inflammation ("xenosialitis") has been demonstrated in human-like Neu5Gc-deficient mice and contributed to carcinoma progression via antibody-mediated inflammation...
2018: PloS One
https://www.readbyqxmd.com/read/29912782/a-randomized-triple-blind-trial-of-cardiac-shock-wave-therapy-on-exercise-tolerance-and-symptoms-in-patients-with-stable-angina-pectoris
#3
Evgeny Shkolnik, Greta Burneikaite, Gabrielius Jakutis, Mikhail Scherbak, Gitana Zuoziene, Birute Petrauskiene, Ekaterina Trush, Yury Vasyuk, Aleksandras Laucevicius, Jelena Celutkiene
BACKGROUND: Despite major advances in managing coronary artery disease and continuous research on alternative techniques to enhance myocardial perfusion and reduce symptoms, coronary artery disease is still one of the leading causes of adult disability worldwide. Cardiac shock-wave therapy (CSWT) has shown promising results in the amelioration of myocardial ischemia in experimental studies; however, clinical results are limited to single-center, mostly uncontrolled and underpowered trials...
June 16, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29909103/prrospective-comparison-of-ffr-derived-from-coronary-ct-angiography-with-spect-perfusion-imaging-in-stable-coronary-artery-disease-the-reassess-study
#4
Niels Peter Rønnow Sand, Karsten Tange Veien, Søren Steen Nielsen, Bjarne Linde Nørgaard, Pia Larsen, Allan Johansen, Søren Hess, Lone Deibjerg, Majed Husain, Anders Junker, Kristian Korsgaard Thomsen, Allan Rohold, Lisette Okkels Jensen
OBJECTIVES: This study sought to compare the per-patient diagnostic performance of coronary computed tomography angiography (CTA)-derived fractional flow reserve (FFRCT ) with that of single-photon emission computed tomography (SPECT), using a fractional flow reserve (FFR) value of ≤0.80 as the reference for diagnosing at least 1 hemodynamically significant stenosis in a head-to-head comparison of patients with intermediate coronary stenosis as determined by coronary CTA. BACKGROUND: No previous study has prospectively compared the diagnostic performance of FFRCT and myocardial perfusion imaging by SPECT in symptomatic patients with intermediate range coronary artery disease (CAD)...
June 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29903734/ige-to-the-mammalian-oligosaccharide-galactose-%C3%AE-1-3-galactose-is-associated-with-increased-atheroma-volume-and-plaques-with-unstable-characteristics
#5
Jeffrey M Wilson, Anh T Nguyen, Alexander J Schuyler, Scott P Commins, Angela M Taylor, Thomas A E Platts-Mills, Coleen A McNamara
OBJECTIVE: Emerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the hypothesis that IgE sensitization to the mammalian oligosaccharide galactose-α-1,3-galactose (α-Gal)-the target allergen of delayed anaphylaxis to red meat-is associated with coronary artery disease. APPROACH AND RESULTS: Total IgE and specific IgE to α-Gal were assayed on sera from 118 subjects who presented for cardiac catheterization and underwent intravascular ultrasound...
June 14, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29903519/transcatheter-or-surgical-treatment-of-severe-aortic-stenosis-and-coronary-artery-disease-a-comparative-analysis-from-the-italian-observant-study
#6
Marco Barbanti, Sergio Buccheri, Davide Capodanno, Paola D'Errigo, Marco Ranucci, Stefano Rosato, Gennaro Santoro, Danilo Fusco, Corrado Tamburino, Fausto Biancari, Fulvia Seccareccia
BACKGROUND: To assess clinical outcomes of patients with concomitant severe aortic stenosis (AS) and coronary artery disease (CAD) who underwent transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) or surgical aortic valve replacement (SAVR) and coronary artery bypass grafting (CABG). METHODS: Data were extracted from the multicenter OBSERVANT study. For the purposes of the present analysis, we included only patients with established stable CAD meeting any of the following inclusion criteria: 1) TAVI patients with CAD undergoing staged PCI or TAVI and PCI in the same session; 2) SAVR patients undergoing combined SAVR and CABG in the same session...
June 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29893361/change-of-inflammatory-factors-in-patients-with-acute-coronary-syndrome
#7
Cai-Yun Ma, Zhen-Ye Xu, Shao-Ping Wang, Hong-Yu Peng, Fang Liu, Jing-Hua Liu, Feng-Xue Ren
Background: Acute coronary syndrome (ACS) is closely related to unstable plaques and secondary thrombosis. The inflammatory cells in plaques and their inflammatory products may be the cause for plaque instability and ruptures. The study aimed to disclose the changes of inflammatory factors including serum intracellular adhesion molecule-1 (ICAM-1), chitinase-3-like protein 1 (YKL-40), and lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients with ACS and its clinical significance...
June 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29893152/ticagrelor-for-the-prevention-of-ischemic-events-in-patients-with-prior-myocardial-infarction-and-peripheral-artery-disease
#8
José C Nicolau, Luciano M Baracioli, Robert P Giugliano
Cardiovascular disease (CVD) is the main cause of death in the world. Coronary artery disease (CAD) is the most common form of CVD presentation, but the prevalence of peripheral artery disease (PAD) is increasing. Patients with polyvascular disease comprise a very high-risk population that has been infrequently studied. Areas covered: The authors review the current evidence of the efficacy and safety of ticagrelor in the setting of acute coronary syndrome and stable patients post-MI with and without PAD and summarize its pharmacokinetics, pharmacodynamics, and regulatory issues...
June 12, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29890282/the-importance-of-anginal-symptoms-characteristics-for-the-prediction-of-coronary-artery-disease-in-a-cohort-of-stable-patients-in-the-modern-era
#9
Georgios Nakas, Aris Bechlioulis, Aikaterini Marini, Konstantinos Vakalis, Mara Bougiakli, Sophia Giannitsi, Konstantina Nikolaou, Emorfili Ioanna Antoniadou, Αnna Kotsia, Konstantina Gartzonika, Georgios Chasiotis, Eleni Bairaktari, Christos S Katsouras, Georgios Triantis, Dimitrios Sionis, Lampros K Michalis, Katerina K Naka
BACKGROUND: Angina is an important clinical symptom indicating underlying coronary artery disease (CAD). Its characteristics are important for the diagnosis and risk-stratification of patients with CAD. Currently, we aimed to investigate the association of chest pain characteristics with the presence of obstructive CAD in a contemporary cohort of patients undergoing coronary angiography for suspected stable CAD. METHODS: Consecutive patients undergoing coronary angiography for suspected stable CAD (n=686) in a single University Hospital Cardiology Department were enrolled...
June 8, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29888611/trimetazidine-in-the-prevention-of-tissue-ischemic-conditions
#10
Manolis S Kallistratos, Leonidas E Poulimenos, Sofia Giannitsi, Pavlos Tsinivizov, Athanasios J Manolis
Trimetazidine (TMZ) is a metabolic agent with significant anti-ischemic properties. By inhibiting the terminal enzyme in the β-oxidation pathway, it shifts the energy substrate metabolism, enhancing glucose metabolism. Thus, it maintains the required energy production with less oxygen consumption, an effect necessary in cases of myocardi. Trimetazidine was recently reaccredited as add-on therapy for symptomatic treatment in patients with stable angina, not adequately controlled or intolerant to first-line therapy...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29888560/-correlation-between-referred-pain-region-and-sensitized-acupoints-in-patients-with-stable-angina-pectoris-and-distribution-of-sensitized-spots-in-rats-with-myocardial-ischemia
#11
Jing Shi, Jian Wang, Yuan Wang, Kun Liu, Yong Fu, Jian-Hua Sun, Ji-Ping Zhao, Xiao-Mei Shao, Si-Feng Feng, You-Wei Yang, Jie Li, Qian-An Cao, Xun He, Mei-Fang Liu, Lu Chen, Xiang Cui, Jiang-Yun Wu, Yuan-Yuan Wu, Xin-Yan Gao, Bing Zhu
OBJECTIVE: To observe the correlation between the referred pain regions of stable angina pectoris (SAP) and the acupoints in coronary heart disease (CHD) patients and to investigate the rule of regional sensitized point distribution in rats. METHODS: A total of 1 046 CHD patients with SAP from 8 hospitals in China were recruited in the present study. The tenderness was palpated along the left and right chest, back, shoulder, upper limb, etc. by a specially-assigned researcher in each hospital...
May 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29885828/selecting-the-best-candidates-for-revascularization-a-challenging-issue-in-stable-coronary-artery-disease
#12
EDITORIAL
Pablo Avanzas, Juan Sanchis
No abstract text is available yet for this article.
May 30, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29885664/zumba-induced-takotsubo-cardiomyopathy-a-case-report
#13
Sana Chams, Skye El Sayegh, Mulham Hamdon, Sarwan Kumar, Zain Kulairi
BACKGROUND: Takotsubo cardiomyopathy or stress cardiomyopathy is characterized by transient left ventricular apical ballooning in the absence of coronary occlusion. The underlying pathophysiological mechanism is still unclear but possible causes have been proposed mainly catecholamine cardiotoxicity, followed by metabolic disturbance, coronary microvascular impairment, and multivessel epicardial coronary artery vasospasm. Takotsubo cardiomyopathy accounts for 1-2% of patients presenting with acute coronary syndrome with the majority of patients diagnosed with Takotsubo cardiomyopathy being women > 55 years of age...
June 10, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29885434/one-year-outcomes-after-ruptured-abdominal-aortic-aneurysms-repair-is-evar-the-best-choice-a-single-center-experience
#14
O Martinelli, C Fenelli, J Ben-Hamida, M Fresilli, F G Irace, V Picone, A Malaj, B Gossetti, L Irace
OBJECTIVE: Treatment of ruptured abdominal aortic aneurysms (rAAAs) is still burdened by high morbidity and mortality. Although endovascular aortic repair (EVAR) offers encouraging results in elective setting, its role as first line strategy to treat rAAA is still debated. Our aim was to compare early and late outcomes in patients undergoing open surgical repair (OSR) compared with those submitted to vs EVAR for rAAAs. METHODS: A retrospective review of data extracted from medical records identified 105 consecutive patients with rAAA who were submitted to open or endovascular repairs from 2008 to 2016...
June 6, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29878340/a-randomized-double-blind-placebo-controlled-study-to-evaluate-the-effect-of-erenumab-on-exercise-time-during-a-treadmill-test-in-patients-with-stable-angina
#15
Christophe Depre, Lubomir Antalik, Amaal Starling, Michael Koren, Osaro Eisele, Robert A Lenz, Daniel D Mikol
OBJECTIVE: To determine the potential impact of erenumab, a human anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody, on total exercise time (TET), time to exercise-induced angina, and ST depression in a double-blind, placebo-controlled study in patients with stable angina due to documented coronary artery disease. BACKGROUND: The relative importance of the CGRP receptor pathway during myocardial ischemia has not been established. METHODS: An exercise treadmill test was conducted following a single IV infusion of erenumab 140 mg or placebo...
May 2018: Headache
https://www.readbyqxmd.com/read/29877974/beta-blocker-therapy-reduces-mortality-in-patients-with-coronary-artery-disease-treated-with-percutaneous-revascularization-a-meta-analysis-of-adjusted-results
#16
Mattia Peyracchia, Daniele Errigo, Sergio Raposeiras Rubin, Federico Conrotto, James J DiNicolantonio, Pierluigi Omedè, Sara Rettegno, Mario Iannaccone, Claudio Moretti, Maurizio D'Amico, Fiorenzo Gaita, Fabrizio D'Ascenzo
AIMS: The long-term impact of beta blockers on prognosis in patients treated with contemporary therapies for coronary artery disease remains to be defined. METHODS AND RESULTS: All observational studies evaluating the impact of beta blockers in patients treated with coronary revascularization and contemporary therapies and adjusted with multivariate analysis were included. All-cause death was the primary endpoint, while Major Adverse Cardiac Events (MACE) (composite endpoint of all-cause death or myocardial infarction, MI) and MI were secondary endpoints...
July 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29877297/impact-of-genetic-variation-in-aldehyde-dehydrogenase-2-and-alcohol-consumption-on-coronary-artery-lesions-in-chinese-patients-with-stable-coronary-artery-disease
#17
Lei Xu, Gang Zhao, Jingfeng Wang, Cheng Shen, Xiao Li, Fei Lu, Hongfa Jiang, George Liu, Kai Hu, Yanhua Tang, Aijun Sun, Junbo Ge
The aim of this study is to investigate the impact of aldehyde dehydrogenase 2 (ALDH2) genotype and alcohol consumption on coronary artery lesions in Chinese patients with stable coronary artery disease (CAD). A total of 753 Chinese patients (73.6% male) diagnosed with stable CAD by coronary angiography were included in the sample. The frequency of the mutated type ALDH2* 2 (including ALDH2* 1/* 2 and ALDH2* 2/* 2) was 44.1% in CAD patients. The mutated ALDH2 carriers were more susceptible to multivessel lesions...
June 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29875140/validity-of-inducible-ischaemia-as-a-surrogate-for-adverse-outcomes-in-stable-coronary-artery-disease
#18
Adam Timmis, Antony Raharja, R Andrew Archbold, Anthony Mathur
Regional myocardial ischaemia is commonly expressed as exertional angina in patients with stable coronary artery disease (CAD). It also associates with prognosis, risk tending to increase with the severity of ischaemia. The validity of myocardial ischaemia as a surrogate for adverse clinical outcomes, however, has not been well established. Thus, in cohort studies, ischaemia testing has failed to influence rates of myocardial infarction and coronary death. Moreover, in clinical studies, pharmacological and interventional treatments that are effective in correcting ischaemia have rarely been shown to reduce cardiovascular (CV) risk...
June 6, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29874661/treatment-of-angina-where-are-we
#19
Cristina Balla, Rita Pavasini, Roberto Ferrari
Ischaemic heart disease is a major cause of death and disability worldwide, while angina represents its most common symptom. It is estimated that approximately 9 million patients in the USA suffer from angina and its treatment is challenging, thus the strategy to improve the management of chronic stable angina is a priority. Angina might be the result of different pathologies, ranging from the "classical" obstruction of a large coronary artery to alteration of the microcirculation or coronary artery spasm...
June 6, 2018: Cardiology
https://www.readbyqxmd.com/read/29873864/periodontal-therapy-and-endothelial-function-in-coronary-artery-disease-a-randomized-controlled-trial
#20
Marco Aurelio L Saffi, Eneida R Rabelo-Silva, Carisi A Polanczyk, Mariana V Furtado, Marlon M Montenegro, Ingrid W J Ribeiro, Cassio Kampits, Cassiano K Rösing, Alex N Haas
OBJECTIVE: To assess the effects of periodontal treatment on endothelial function in patients with coronary artery disease. MATERIALS AND METHODS: A randomized controlled trial was conducted with 69 patients with stable coronary disease and severe periodontitis. The test group received non-surgical periodontal therapy consisting of personalized oral hygiene instructions, subgingival scaling and root planing per quadrant, whereas the control group received equal treatment after the study period...
June 6, 2018: Oral Diseases
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