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Amanda L Tatler, Anthony Habgood, Joanne Porte, Alison E John, Anastasios Stavrou, Emily Hodge, Cheryl Kerama-Likoko, Shelia M Violette, Paul H Weinreb, Alan J Knox, Geoffrey Laurent, Helen Parfrey, Paul John Wolters, William Wallace, Siegfried Alberti, Alfred Nordheim, Gisli Jenkins
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with high mortality. Active TGFβ1 is considered central to the pathogenesis of IPF. A major mechanism of TGFβ1 activation in the lung involves the epithelially restricted αvβ6 integrin. Expression of the αvβ6 integrin is dramatically increased in IPF. How αvβ6 integrin expression is regulated in the pulmonary epithelium is unknown. Here we identify a region in the β6 subunit gene (ITGB6) promoter acting to markedly repress basal gene transcription, which responds to both the Ets domain-containing protein Elk1 (Elk1) and the glucocorticoid receptor (GR)...
April 29, 2016: Journal of Biological Chemistry
Shannon M Conley, Michael W Stuck, Justin L Burnett, Dibyendu Chakraborty, Seifollah Azadi, Steven J Fliesler, Muna I Naash
Mutations in the photoreceptor tetraspanin gene peripherin-2/retinal degeneration slow (PRPH2/RDS) cause both rod- and cone-dominant diseases. While rod-dominant diseases, such as autosomal dominant retinitis pigmentosa, are thought to arise due to haploinsufficiency caused by loss-of-function mutations, the mechanisms underlying PRPH2-associated cone-dominant diseases are unclear. Here we took advantage of a transgenic mouse line expressing an RDS mutant (R172W) known to cause macular degeneration (MD) in humans...
June 15, 2014: Human Molecular Genetics
Dan Calugaru
After presenting both the prevalence and the staging of the age-related macular degeneration (AMD), the disease progression is discussed; it is determined primarily by genetic factors but is also influenced by environmental, demographic and behavioral factors. The genes working by means of the high-density lipoprotein cholesterol (HDL) pathway have critical roles in the drusen initiation in the early AMD stages. After the drusen have accumulated between retinal pigment epithlium (RPE) and Bruch's membrane, the genes acting in the alternative complement pathway are activated so influencing in this way the progression from the intermediate and large drusen to the advanced AMD stages (e...
2012: Oftalmologia
Nan Li, Zhaobing Qin, Mingmin Dong
OBJECTIVE: To observe the expression of MMP-9, TNF-alpha in cholesteatoma and to determine their roles in the destruction of bone. METHOD: Immunohistochemical method (SP) and the computer image quantitative analysis were used to examine the expression of TNF-alpha, MMP-9 in 22 samples from cholesteatoma and 20 normal cases. At the same time, the correlation between the expressions of the two indexes and the erosion of ossicles were observed. RESULT: MMP-9 protein was only expressed in cholesteatoma stromal cells...
July 2004: Lin Chuang Er Bi Yan Hou Ke za Zhi, Journal of Clinical Otorhinolaryngology
No abstract text is available yet for this article.
March 1959: Archives D'ophtalmologie et Revue Générale D'ophtalmologie
Sheng-Tao Yuan, Xi-Qi Hu, Jian-Ping Lu, Hayashi KeiKi, Wei-Rong Zhai, Yue-E Zhang
AIM:To investigate the expression of integrins in rats liver during 3'-Me -DAB induced hepatocarcinogenesis and to find out the relationship between integrins and liver cancer metastasis.METHODS:The expressions of integrins alpha(1), alpha(2), alpha(3) and alpha(5) and epidermal keratin (EK) were observed by immunohisto chemical PAP method.RESULTS:In the normal liver tissues, hepatocytes express integrins alpha(1) and alpha(5) and in the bile duct epithlium, EK. In liver cirrhosis, hepatocytes highly express integrins alpha(1), alpha(2), alpha(3) and alpha5and in hyperplastic bile duct epithelium, integrins alpha(1), alpha(5) and EK...
April 2000: World Journal of Gastroenterology: WJG
D Han, Y Bian, W Xia
OBJECTIVE: To investigate the relation between the morphology and the biological characteristics of laryngeal carcinoma. METHODS: The freeze-cracking method was used to examine 126 specimens of the larynx under scanning electron microscope (SEM). The specimens were obtained from 12 patients suffering from laryngeal cancer and 4 patients with normal larynx. RESULTS: (1) In the normal larynx, the squamous-cell epithelium showed marked keratinization and the intracellular bridges were clear and regular...
January 1997: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
M W Li, Q Y Sun, H Liu, C W Duan, G J Hu, D Y Chen
Calcium was localized by in situ precipitation with potassium antimonate during epididymal maturation of the mouse and guinea pig sperms. In caput epididymis the calcium in mouse sperm head was mainly localized on the inner surface of tha outer acrosomal membrane (OAM) in preacrosomal region. During the passage from the caput epididymis to the cauda epididymis the calcium amount of mouse sperm did not undergo apparent changes. In comparison with mouse sperm, there were a few fine calcium deposite granules on the inner surface of the guinea pig sperm OAM on the abdomen side at the caput epididymis stage, but these granules disappeared at the cauda epididymis stage...
June 1996: Shi Yan Sheng Wu Xue Bao
D W Hay
1. Endothelin (1 nM-0.3 microM) produced a concentration-dependent contraction of guinea-pig epithelium-containing (intact) trachea (EC50 = 30.9 nM). Endothelin was a less potent agonist than leukotriene D4 (LTD4; EC50 = 0.77 nM), but was more potent than carbachol (EC50 = 0.15 microM) or substance P (EC50 = 1.4 microM). Endothelin was a more potent contractile agent in rat endothelium-denuded aorta (EC50 = 2.1 nM) than in guinea-pig trachea. 2. Endothelin-induced contraction in guinea-pig trachea was unaffected by mepyramine (10 microM), atropine (1 microM), SK&F 104353 (10 microM), a leukotriene receptor antagonist, or SQ 29,548 (1 microM), a thromboxane receptor antagonist...
June 1990: British Journal of Pharmacology
W A Manschot
I used seven eyes obtained postmortem to study the mechanism of fixation of a Binkhorst two-loop iridocapsular lens. During the first postoperative weeks, vitreous pressure and traction on the posterior lens capsule exerted by the zonular fibers pushed the loops of the iridocapsular lens against the iris. The zonular traction maintained the posterior capsule taut so that the vitreous pressure was distributed equally over the entire surface of the capsular diaphragm. Lens epithelial cells proliferated around the margin of the capsular breaks and defects and formed plaques or masses of spindle-shaped cells...
April 1978: American Journal of Ophthalmology
K M Svetikova
Proliferative processes were studied in epithelial cells of skin autografts and the surrounding skin in mice of CBA line. In the animals subjected to the operation but without cortisone injection (Fig. 1, a and Fig. 2, delta), a high proliferative activity in the skin epithelial cells surrounding the autograft was observed during the whole course of the experiment. In the cells of the autograft, the mitotic activity, after inhibition, restored quickly up to the original level, and in 10 days it sharply increased and did not differ from that in the epithelium of the surrounding skin...
April 1978: Arkhiv Anatomii, Gistologii i émbriologii
H Ishikawa, M Shiino, E G Rennels
2A8 clonal cells derived from the epithlium of Rathke's pouch of fetal rats were cultured in growth medium supplemented with fresh rat serum, median-eminence extract and 1-thyroxine. Then, in order to isolate gonadotrophs, cyanogen bromide-activated Sepharose whichwas conjugated with LHRH (LHRH-Sepharose) was added to the culture medium. Fourteen days after incubation of 2A8 cells with LHRH-Sepharose, agranular and granular cells were rapidly bound to LHRH-Sepharose when fresh serum had previously been added in the medium...
May 18, 1978: Cell and Tissue Research
C S Freeman, Y J Topper
In pursuit of a model system in which to determine whether exposure to progesterone is necessary for mammary epithlial cells to develop their differentiative potential, hormone-dependent growth of the mammary epithelial rudiment in adult male mice has been reexplored. The formation of ductal cells can be effected by administration of estradiol in the absence of endogenous progesterone and glucocorticoid, using adrenalectomized-castrated animals. The resulting epithlium contains three times more lactose synthetase activity, per epithelial cell, than that in midpregnant mice...
March 1978: Journal of Toxicology and Environmental Health
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