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https://www.readbyqxmd.com/read/28807570/albumin-bilirubin-grade-predicts-the-outcomes-of-liver-resection-versus-radiofrequency-ablation-for-very-early-early-stage-of-hepatocellular-carcinoma
#1
Charing Ching-Ning Chong, Anthony Wing-Hung Chan, John Wong, Cheuk-Man Chu, Stephen Lam Chan, Kit-Fai Lee, Simon Chun-Ho Yu, Ka-Fai To, Philip Johnson, Paul Bo-San Lai
BACKGROUND AND PURPOSE: Whether liver resection or ablation should be the first-line treatment for very early/early hepatocellular carcinoma (HCC) in patients who are candidates for both remains controversial. The aim of this study was to determine if the newly-developed Albumin-Bilirubin (ALBI) grade might help in treatment selections and to evaluate the survival of patients treated with liver resection and radiofrequency ablation (RFA). METHODS: Patients with BCLC stage 0/A HCC who were treated with curative liver resection and RFA from 2003 to 2013 were included...
August 11, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28688815/albumin-bilirubin-and-platelet-albumin-bilirubin-grades-accurately-predict-overall-survival-in-high-risk-patients-undergoing-conventional-transarterial-chemoembolization-for-hepatocellular-carcinoma
#2
Jan Hansmann, Maximilian J Evers, James T Bui, R Peter Lokken, Andrew J Lipnik, Ron C Gaba, Charles E Ray
PURPOSE: To evaluate albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grades in predicting overall survival in high-risk patients undergoing conventional transarterial chemoembolization for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This single-center retrospective study included 180 high-risk patients (142 men, 59 y ± 9) between April 2007 and January 2015. Patients were considered high-risk based on laboratory abnormalities before the procedure (bilirubin > 2...
July 6, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28685924/combining-albumin-bilirubin-score-with-future-liver-remnant-predicts-post-hepatectomy-liver-failure-in-hbv-associated-hcc-patients
#3
Heng Zou, Yu Wen, Kun Yuan, Xiong-Ying Miao, Li Xiong, Kui-Jie Liu
BACKGROUND AND AIMS: Accurate assessment of liver functional reserve pre-operatively is vital for safe hepatic resection. The ALBI score is a new model for assessing liver function. This study aimed to evaluate the value of combining ALBI score with sFLR in predicting post-operative morbidity and PHLF in HCC patients who underwent hepatectomy. METHODS: Patients undergoing three-dimensional CT reconstruction prior to hepatectomy for HCC between January 2015 and January 2017 were enrolled...
July 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28672011/prognostic-role-of-noninvasive-liver-reserve-markers-in-patients-with-hepatocellular-carcinoma-undergoing-transarterial-chemoembolization
#4
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Cheng-Yuan Hsia, Yun-Hsuan Lee, Rheun-Chuan Lee, Yi-Hsiang Huang, Fa-Yauh Lee, Ming-Chih Hou, Ya-Ju Tsai, Teh-Ia Huo
BACKGROUND: Various noninvasive liver reserve markers were proposed to indicate the severity of liver damage. However, the role and feasibility of these markers to predict the prognosis of patients with hepatocellular carcinoma (HCC) are unknown. We aimed to identify the prognostic role of the 8 currently used hepatic reserve markers in patients with HCC undergoing transarterial chemoembolization (TACE). METHODS: Between 2002 and 2013, a total of 881 patients with HCC undergoing TACE were prospectively identified and retrospectively analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28626732/albumin-bilirubin-albi-grade-as-part-of-the-evidence-based-clinical-practice-guideline-for-hcc-of-the-japan-society-of-hepatology-a-comparison-with-the-liver-damage-and-child-pugh-classifications
#5
Atsushi Hiraoka, Takashi Kumada, Masatoshi Kudo, Masashi Hirooka, Kunihiko Tsuji, Ei Itobayashi, Kazuya Kariyama, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Toshifumi Tada, Hidenori Toyoda, Kazuhiro Nouso, Kouji Joko, Hideki Kawasaki, Yoichi Hiasa, Kojiro Michitaka
AIM/BACKGROUND: The purpose of this study was to evaluate the validity of 3 classifications for assessing liver function, the liver damage and Child-Pugh classifications and the newly proposed albumin-bilirubin (ALBI) grade, in order to examine the feasibility of evaluating hepatic function using ALBI grade with the hepatocellular carcinoma (HCC) treatment algorithm used in Japan. METHODS: We analyzed the medical records of 3,495 Japanese HCC patients admitted from 2000 to 2015, which were comprised of 1,580 patients hospitalized in the Ehime Prefecture area and used as a training cohort (Ehime group), and 1,915 others who were used for validation (validation group)...
June 2017: Liver Cancer
https://www.readbyqxmd.com/read/28614241/albumin-bilirubin-albi-score-at-admission-predicts-possible-outcomes-in-patients-with-acute-on-chronic-liver-failure
#6
Bo Chen, Sha Lin
The albumin-bilirubin (ALBI) score is a new model for assessing the severity of liver dysfunction. The purpose of the present study is to investigate the prognostic value of the ALBI score in predicting the 3-month outcome of patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (AoCLF).This study included 84 patients with HBV-AoCLF, 56 chronic hepatitis B (CHB) patients, and 48 healthy controls (HCs). The virological parameters and biochemical examination of blood were obtained after 12 hours of fasting...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489642/pupillary-reflex-for-evaluation-of-thoracic-paravertebral-block-a-prospective-observational-feasibility-study
#7
Baptiste Duceau, Mélanie Baubillier, Gaëlle Bouroche, Aline Albi-Feldzer, Christian Jayr
BACKGROUND: Although thoracic paravertebral block (TPVB) is recommended in major breast surgery, there is no gold standard to assess the success of TPVB. Pupillary dilation reflex (PDR) is the variation of the pupillary diameter after a noxious stimulus. The objective was to evaluate the feasibility of recording the PDR to assess analgesia in an anesthetized thoracic dermatome after TPVB. METHODS: This prospective, observational, single-center study included 32 patients requiring breast surgery under general anesthesia and TPVB...
May 4, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28343896/assessment-of-hepatic-function-decline-after-stereotactic-body-radiation-therapy-for-primary-liver-cancer
#8
Diego A S Toesca, Evan C Osmundson, Rie von Eyben, Jenny L Shaffer, Albert C Koong, Daniel T Chang
PURPOSE: This study aims to determine how the albumin-bilirubin (ALBI) score compares with the Child-Pugh (CP) score for assessing liver function following stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: In total, 60 patients, 40 with hepatocellular carcinoma (HCC) and 20 with cholangiocarcinoma (CCA), were treated with SBRT. Liver function panels were obtained before and at 1, 3, 6, and 12 months after SBRT. Laboratory values were censored after locoregional recurrence, further liver-directed therapies, or liver transplant...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28169483/prognostic-significance-of-combined-albumin-bilirubin-and-tumor-node-metastasis-staging-system-in-patients-who-underwent-hepatic-resection-for-hepatocellular-carcinoma
#9
Norifumi Harimoto, Tomoharu Yoshizumi, Kazuhito Sakata, Akihisa Nagatsu, Takashi Motomura, Shinji Itoh, Noboru Harada, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: In recent years, the establishment of new staging systems for hepatocellular carcinoma (HCC) has been reported worldwide. The system combining albumin-bilirubin (ALBI) with tumor-node-metastasis stage, developed by the Liver Cancer Study Group of Japan, was called the ALBI-T score. METHODS: Patient data were retrospectively collected for 357 consecutive patients who had undergone hepatic resection for HCC with curative intent between January 2004 and December 2015...
February 7, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28125820/transarterial-chemo-embolisation-of-hepatocellular-carcinoma-impact-of-liver-function-and-vascular-invasion
#10
Imam Waked, Sarah Berhane, Hidenori Toyoda, Stephen L Chan, Nicholas Stern, Daniel Palmer, Toshifumi Tada, Winnie Yeo, Frankie Mo, Dominik Bettinger, Martha M Kirstein, Mercedes Iñarrairaegui, Asmaa Gomaa, Arndt Vogel, Tim Meyer, Bruno Sangro, Paul Lai, Takashi Kumada, Philip J Johnson
BACKGROUND: Transarterial chemo-embolisation (TACE) is recommended for patients with BCLC intermediate stage hepatocellular carcinoma (stage B), particularly in patients with good underlying liver function and minimal symptoms. The hepatoma arterial embolisation prognostic (HAP) score combines measures of liver function and tumour-related factors to offer a simple prognostic scoring system. The Albumin-Bilirubin (ALBI) grade permits assessment of the impact of liver function on survival...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27862671/usefulness-of-albumin-bilirubin-grade-for-evaluation-of-long-term-prognosis-for-hepatitis-b-related-cirrhosis
#11
R-C Chen, Y-J Cai, J-M Wu, X-D Wang, M Song, Y-Q Wang, M-H Zheng, Y-P Chen, Z Lin, K Q Shi
Long-term prognosis varies widely among patients with hepatitis B virus (HBV)-related liver cirrhosis. Our study aimed to investigate the applicability of albumin-bilirubin (ALBI), Child-Pugh and model for end-stage liver disease (MELD) scores to the long-term prognosis prediction of HBV-related cirrhosis. Patients diagnosed with HBV-associated cirrhosis from the First Affiliated Hospital of Wenzhou Medical University between January 2010 and December 2015 were enrolled in this study. The patients were followed up every 3 months...
March 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27842668/hepatobiliary-phase-images-using-gadolinium-ethoxybenzyl-diethylenetriamine-penta-acetic-acid-enhanced-mri-as-an-imaging-surrogate-for-the-albumin-bilirubin-grading-system
#12
COMPARATIVE STUDY
Yasuo Takatsu, Satoshi Kobayashi, Tosiaki Miyati, Toshiki Shiozaki
OBJECTIVES: To clarify the correlation between hepatobiliary phase (HBP) images using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) and albumin-bilirubin (ALBI) grading system. MATERIALS AND METHODS: We evaluated 220 consecutive patients who underwent liver magnetic resonance imaging with Gd-EOB-DTPA. Quantitative liver-spleen contrast ratio (Q-LSC) was calculated in HBP images approximately 20min after Gd-EOB-DTPA administration. To evaluate the degree of association between Q-LSC and ALBI grade, the Child-Pugh (C-P) score was used for comparison...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27835570/prognostic-nutritional-index-predicts-short-term-outcomes-after-liver-resection-for-hepatocellular-carcinoma-within-the-milan-criteria
#13
Mengyun Ke, Tao Xu, Na Li, Yifan Ren, Aihua Shi, Yi Lv, Haiqi He
BACKGROUND: The prognostic nutritional index (PNI) is calculated based on the serum albumin concentration and the total lymphocyte count. The aim of this study was to investigate the prognostic ability of the PNI for postoperative complications after liver resection to treat hepatocellular carcinoma (HCC) within the Milan criteria. RESULTS: Postoperative complications were observed in 166 (44.6%) patients. The optimal cutoff value of the PNI was set at 45.6 for postoperative complications...
December 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27696519/albi-and-palbi-grade-predict-survival-for-hcc-across-treatment-modalities-and-bclc-stages-in-the-meld-era
#14
Po-Hong Liu, Chia-Yang Hsu, Cheng-Yuan Hsia, Yun-Hsuan Lee, Yi-You Chiou, Yi-Hsiang Huang, Fa-Yauh Lee, Han-Chieh Lin, Ming-Chih Hou, Teh-Ia Huo
BACKGROUND: The severity of liver dysfunction in hepatocellular carcinoma (HCC) is often estimated with Child-Turcotte-Pugh (CTP) classification or model for end-stage liver disease (MELD) score. We aim to investigate the performance of albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grade, which are recently reported to be simple and objective measurements for liver reserve in HCC. METHODS: Between 2002 and 2014, consecutive 3,182 HCC patients were enrolled to follow up their survival...
October 3, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27677714/the-albi-grade-provides-objective-hepatic-reserve-estimation-across-each-bclc-stage-of-hepatocellular-carcinoma
#15
David J Pinato, Rohini Sharma, Elias Allara, Clarence Yen, Tadaaki Arizumi, Keiichi Kubota, Dominik Bettinger, Jeong Won Jang, Carlo Smirne, Young Woon Kim, Masatoshi Kudo, Jessica Howell, Ramya Ramaswami, Michela E Burlone, Vito Guerra, Robert Thimme, Mitsuru Ishizuka, Justin Stebbing, Mario Pirisi, Brian I Carr
BACKGROUND & AIMS: Overall survival (OS) is a composite clinical endpoint in hepatocellular carcinoma (HCC) due to the mutual influence of cirrhosis and active malignancy in dictating patient's mortality. The ALBI grade is a recently described index of liver dysfunction in hepatocellular carcinoma, based solely on albumin and bilirubin levels. Whilst accurate, this score lacks cross-validation, especially in intermediate stage HCC, where OS is highly heterogeneous. METHODS: We evaluated the prognostic accuracy of the ALBI grade in estimating OS in a large, multi-centre study of 2426 patients, including a large proportion of intermediate stage patients treated with chemoembolization (n=1461) accrued from Europe, the United States and Asia...
February 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/27674053/assessment-of-hepatic-function-decline-after-stereotactic-body-radiation-therapy-for-primary-liver-tumors-using-the-albumin-bilirubin-albi-score
#16
D A S Toesca, E Osmundson, J Shaffer, R von Eyben, A C Koong, D T Chang
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27644664/talin-1-and-non-invasive-fibrosis-models-in-the-assessment-of-patients-with-hepatocellular-carcinoma
#17
Ayman Alsebaey, Eman Aly Ahmedy
BACKGROUND: Hepatocellular carcinoma (HCC) is a dreadful complication of end stage liver disease with high morbidity and mortality. AIM: The aim was to assess the role of serum talin-1 and non-invasive brosis in patients with HCC. MATERIALS AND METHODS: A total of eighty seven subjects were enrolled, with 22 two healthy individuals as a control group (n=22), 22 patients in the cirrhosis group and finally 43 in the group with HCC diagnosed with positive triphasic CT abdomen criteria...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27619809/albumin-bilirubin-score-predicting-short-term-outcomes-including-bile-leak-and-post-hepatectomy-liver-failure-following-hepatic-resection
#18
Nikolaos Andreatos, Neda Amini, Faiz Gani, Georgios A Margonis, Kazunari Sasaki, Vanessa M Thompson, David J Bentrem, Bruce L Hall, Henry A Pitt, Ana Wilson, Timothy M Pawlik
INTRODUCTION: Post-operative bile leak (BL) and post hepatectomy liver failure (PHLF) are the major potential sources of morbidity among patients undergoing liver resection. We sought to define the incidence of BL and PHLF among a large cohort of patients, as well as examine the prognostic impact of model for end-stage liver disease (MELD) and albumin-bilirubin (ALBI) scores to predict these short-term outcomes. MATERIALS AND METHODS: Patients who underwent a hepatectomy between January 1, 2014 and December 31, 2014 were identified using the National Surgical Quality Improvement Program (NSQIP) liver-targeted database...
February 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27558521/prognostic-value-of-the-albumin-bilirubin-grade-in-patients-with-hepatocellular-carcinoma-validation-in-a-chinese-cohort
#19
Mu-Xing Li, Hong Zhao, Xin-Yu Bi, Zhi-Yu Li, Zhen Huang, Yue Han, Jian-Guo Zhou, Jian-Jun Zhao, Ye-Fan Zhang, Jian-Qiang Cai
AIM: The prognostic value of the newly raised objective liver function assessment tool, the albumin-bilirubin (ALBI) grade, in patients with hepatocellular carcinoma has not been fully validated. We aimed to compare the performance of ALBI grade with the specific Child-Pugh (C-P) score in predicting prognosis in this study. METHODS: The clinical data of 491 C-P class A patients who underwent liver resection as initial therapy from January 2000 to December 2007 in Cancer Hospital, Chinese Academy of Medical Sciences (Beijing, China) were retrospectively analyzed...
August 25, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27519630/free-water-elimination-improves-test-retest-reproducibility-of-diffusion-tensor-imaging-indices-in-the-brain-a-longitudinal-multisite-study-of-healthy-elderly-subjects
#20
Angela Albi, Ofer Pasternak, Ludovico Minati, Moira Marizzoni, David Bartrés-Faz, Núria Bargalló, Beatriz Bosch, Paolo Maria Rossini, Camillo Marra, Bernhard Müller, Ute Fiedler, Jens Wiltfang, Luca Roccatagliata, Agnese Picco, Flavio Mariano Nobili, Oliver Blin, Julien Sein, Jean-Philippe Ranjeva, Mira Didic, Stephanie Bombois, Renaud Lopes, Régis Bordet, Hélène Gros-Dagnac, Pierre Payoux, Giada Zoccatelli, Franco Alessandrini, Alberto Beltramello, Antonio Ferretti, Massimo Caulo, Marco Aiello, Carlo Cavaliere, Andrea Soricelli, Lucilla Parnetti, Roberto Tarducci, Piero Floridi, Magda Tsolaki, Manos Constantinidis, Antonios Drevelegas, Giovanni Frisoni, Jorge Jovicich
Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal studies. However, it is not clear if these two models differ in their test-retest reproducibility. This study compares a bi-tensor model for FWE with DTI by extending a previous longitudinal-reproducibility 3T multisite study (10 sites, 7 different scanner models) of 50 healthy elderly participants (55-80 years old) scanned in two sessions at least 1 week apart...
January 2017: Human Brain Mapping
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