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albi score

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https://www.readbyqxmd.com/read/29777455/combined-preoperative-albi-and-fib-4-is-associated-with-recurrence-of-hepatocellular-carcinoma-after-curative-hepatectomy
#1
Rui Liao, De-Wei Li, Cheng-You Du, Ming Li
BACKGROUND AND PURPOSE: Chronic inflammatory response is a risk factor for hepatocarcinogenesis and recurrence. This study aimed to develop a nomogram incorporating the combined albumin-bilirubin (ALBI) and fibrosis-4 (FIB-4) scores and the peritumoral inflammation score (PIS) to predict postoperative recurrence-free survival (RFS) of hepatocellular carcinoma (HCC). METHODS: The prognostic roles of preoperative ALBI and FIB-4 scores for HCC recurrence were investigated, and a nomogram was developed...
May 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29755770/safety-and-initial-efficacy-of-radiation-segmentectomy-for-the-treatment-of-hepatic-metastases%C3%A2
#2
Craig Meiers, Amy Taylor, Brian Geller, Beau Toskich
Background: Hepatic metastatectomy and ablation are associated with prolonged survival, but not all lesions are anatomically amenable to these therapies. We evaluated safety and initial efficacy of segmental ablative transarterial radioembolization, or radiation segmentectomy (RS), as a treatment for hepatic metastases. Methods: A single institution retrospective analysis was performed of patients with hepatic metastases, determined unamenable to resection by a multidisciplinary tumor board, treated with RS from 2015-2017...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29739046/albumin-bilirubin-score-predicts-short-term-mortality-in-patients-with-hepatitis-b-virus-related-decompensated-cirrhosis
#3
Xiao T Qi
BACKGROUND: The albumin-bilirubin (ALBI) score is a new index for assessing the severity of liver dysfunction. Hepatitis B virus (HBV) related decompensated cirrhosis (HBV-DeCi) has a high short-term mortality rate. The purpose of this study was to elucidate the prognostic role of the ALBI score in patients with HBV-DeCi. METHODS: This retrospective study included 81 patients who had been diagnosed with HBV-DeCi. All patients were followed up with for at least 2 months, and the relationships between prognosis and ALBI score were analysed...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29580046/initial-clinical-outcomes-of-proton-beam-radiotherapy-for-hepatocellular-carcinoma
#4
Jeong Il Yu, Gyu Sang Yoo, Sungkoo Cho, Sang Hoon Jung, Youngyih Han, Seyjoon Park, Boram Lee, Wonseok Kang, Dong Hyun Sinn, Yong-Han Paik, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Hee Chul Park
Purpose: This study aimed to evaluate the initial outcomes of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) in terms of tumor response and safety. Materials and Methods: HCC patients who were not indicated for standard curative local modalities and who were treated with PBT at Samsung Medical Center from January 2016 to February 2017 were enrolled. Toxicity was scored using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Tumor response was evaluated using modified Response Evaluation Criteria in Solid Tumors (mRECIST)...
March 29, 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29555927/comparison-of-twelve-liver-functional-reserve-models-for-outcome-prediction-in-patients-with-hepatocellular-carcinoma-undergoing-surgical-resection
#5
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Cheng-Yuan Hsia, Chien-Wei Su, Yun-Hsuan Lee, Yi-Hsiang Huang, Fa-Yauh Lee, Ming-Chih Hou, Teh-Ia Huo
Various noninvasive liver functional reserve models have been proposed, but their prognostic ability in patients with hepatocellular carcinoma (HCC) is unclear. We aimed to investigate the performance of twelve noninvasive liver reserve models in HCC patients undergoing surgical resection. A total of 645 patients undergoing resection were prospectively identified and retrospectively analyzed. Tumor recurrence, overall survival, and independent prognostic factors were evaluated by the Cox proportional hazards model...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29516241/albumin-bilirubin-and-platelet-albumin-bilirubin-grades-do-not-predict-survival-after-transjugular-intrahepatic-portosystemic-shunt-creation
#6
Ramzy C Khabbaz, R Peter Lokken, Yi-Fan Chen, Andrew J Lipnik, James T Bui, Charles E Ray, Ron C Gaba
PURPOSE: To evaluate the capability of albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grades in predicting transplant-free survival (TFS) in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) creation. MATERIALS AND METHODS: This single-center retrospective study included 342 ALBI and 337 PALBI patients (62% men; age 53-54 years) with cirrhosis (median MELD 15) and portal hypertension complications (variceal bleeding, 55%; ascites, 35%; other, 10%) who underwent TIPS between 1998 and 2017...
March 7, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29495004/a-comparative-study-of-albumin-bilirubin-score-with-child-pugh-score-model-for-end-stage-liver-disease-score-and-indocyanine-green-r15-in-predicting-posthepatectomy-liver-failure-for-hepatocellular-carcinoma-patients
#7
Heng Zou, Xin Yang, Qing-Long Li, Qing-Xiang Zhou, Li Xiong, Yu Wen
BACKGROUND: The albumin-bilirubin (ALBI) grade is a newly proposed model for assessing the hepatic function. This study aimed to compare the value of the ALBI score with Child-Pugh score, model for end-stage liver disease (MELD) score and indocyanine green (ICG) R15 in predicting posthepatectomy liver failure (PHLF). METHODS: Patients undergoing curative resection for hepatocellular carcinoma (HCC) between January 2014 and June 2017 were enrolled. The values of the Child-Pugh score, MELD score, ICG R15 and ALBI score in predicting PHLF were evaluated...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/29456711/value-of-the-albumin-bilirubin-score-in-the-evaluation-of-hepatitis-b-virus-related-acute-on-chronic-liver-failure-liver-cirrhosis-and-hepatocellular-carcinoma
#8
Qing Lei, Yinhua Zhang, Changzheng Ke, Chunchun Yan, Ping Huang, Haixia Shen, Huiting Lei, Yue Chen, Jie Luo, Zhongji Meng
The aim of the present study was to investigate the value of the albumin-bilirubin (ALBI) score in the assessment of the disease conditions of hepatitis B virus (HBV)-related acute-on-chronic liver failure (HBV-ACLF), HBV-related liver cirrhosis (HBV-LC) and HBV-related hepatocellular carcinoma (HBV-HCC). A total of 395 patients with HBV-ACLF, HBV-LC, or HBV-HCC were retrospectively studied. The ALBI, Child-Turcotte-Pugh (CTP), and Model for End-Stage Liver Disease (MELD) scores of the patients were calculated, and the relationships between the ALBI score and the CTP and MELD scores were investigated...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455421/impact-of-baseline-characteristics-on-outcomes-of-advanced-hcc-patients-treated-with-sorafenib-a-secondary-analysis-of-a-phase-iii-study
#9
RANDOMIZED CONTROLLED TRIAL
Omar Abdel-Rahman
BACKGROUND: The current study aims to investigate the impact of baseline characteristics on the outcomes of sorafenib-treated advanced Hepatocellular carcinoma (HCC) patients in the setting of a clinical trial. METHODS: This is a secondary analysis of the comparator arm (sorafenib arm) of the NCT00699374 study which is a phase III multicenter study conducted between 2008 and 2010. The univariate probability of overall and progression-free survival was assessed among different patient subsets through Kaplan-Meier analysis and log-rank testing...
May 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29442276/novel-albumin-bilirubin-grade-based-risk-prediction-model-for-patients-with-hepatocellular-carcinoma-undergoing-chemoembolization
#10
Jung Hee Kim, Dong Hyun Sinn, Jeong-Hoon Lee, Dongho Hyun, Sung Ki Cho, Sung Wook Shin, Young Chang, Yoon Jun Kim, Jung-Hwan Yoon, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Moon Seok Choi
BACKGROUND: Recently, albumin-bilirubin (ALBI) grade has been suggested as a better surrogate for hepatic functional reserve for patients with hepatocellular carcinoma (HCC). AIMS: We developed and validated a novel prediction model to predict outcome for HCC patients who underwent transcatheter arterial chemoembolization (TACE) as a first-line therapy. METHODS: From a multivariate Cox regression model for overall survival, five objective variables (ALBI grade), the Barcelona clinic liver cancer (BCLC) stage, response after the first TACE session, Alpha-fetoprotein level, and sex were chosen and the ABRAS score was developed from the derivation cohort (n = 476) and scored to generate an 8-point risk prediction model...
April 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29438135/assessment-of-prognostic-performance-of-albumin-bilirubin-child-pugh-and-model-for-end-stage-liver-disease-scores-in-patients-with-liver-cirrhosis-complicated-with-acute-upper-gastrointestinal-bleeding
#11
Sofia A Xavier, Ricardo Vilas-Boas, Pedro Boal Carvalho, Joana T Magalhães, Carla M Marinho, José B Cotter
OBJECTIVE: The Albumin-Bilirubin (ALBI) score was developed recently to assess the severity of liver dysfunction. We aimed to assess its prognostic performance in patients with liver cirrhosis complicated with upper gastrointestinal bleeding (UGIB) while comparing it with Child-Pugh (CP) and Model for End-stage Liver Disease (MELD) scores. PATIENTS AND METHODS: This was a retrospective unicentric study, including consecutive adult patients with cirrhosis admitted for UGIB between January 2011 and November 2015...
June 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29413273/safety-and-efficacy-of-accelerated-hypofractionation-and-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma-patients-with-varying-degrees-of-hepatic-impairment
#12
Nima Nabavizadeh, Joseph G Waller, Robert Fain, Yiyi Chen, Catherine R Degnin, David A Elliott, Brandon T Mullins, Ishan A Patel, Brandon A Dyer, Kareem Fakhoury, Willscott E Naugler, Khashayar Farsad, James A Tanyi, Martin Fuss, Charles R Thomas, Arthur Y Hung
PURPOSE: To report the toxicities and outcomes for stereotactic body radiation therapy (SBRT) and accelerated hypofractionated radiation therapy (AHRT) in patients with Child-Pugh (CP) class A, B, or C and albumin-bilirubin (ALBI) score 1, 2, or 3 hepatocellular carcinoma. METHODS AND MATERIALS: We retrospectively reviewed the data from 146 patients with hepatocellular carcinoma who had undergone SBRT (50 Gy in 5 fractions) or AHRT (45 Gy in 18 fractions). The primary endpoint was liver toxicity, defined as an increase in the CP score of ≥2 within 6 months of radiation therapy...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29353652/modeling-of-normal-tissue-complications-using-imaging-and-biomarkers-after-radiation-therapy-for-hepatocellular-carcinoma
#13
Issam El Naqa, Adam Johansson, Dawn Owen, Kyle Cuneo, Yue Cao, Martha Matuszak, Latifa Bazzi, Theodore S Lawrence, Randall K Ten Haken
PURPOSE: To develop normal tissue complications (NTCP) models for hepatocellular cancer (HCC) patients who undergo liver radiation therapy (RT) and to evaluate the potential role of functional imaging and measurement of blood-based circulating biological markers before and during RT to improve the performance of these models. METHODS AND MATERIALS: The data from 192 HCC patients who had undergone RT from 2005 to 2014 were evaluated. Of the 192 patients, 146 had received stereotactic body RT (SBRT) and 46 had received conventional RT to a median physical tumor dose of 49...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29352659/microwave-ablation-provides-better-survival-than-liver-resection-for-hepatocellular-carcinoma-in-patients-with-borderline-liver-function-application-of-albi-score-to-patient-selection
#14
Charing C N Chong, Kit-Fai Lee, Cheuk-Man Chu, Anthony W H Chan, John Wong, Stephen L Chan, Hon-Ting Lok, Andrew K Y Fung, Anthony K W Fong, Yue S Cheung, Simon C H Yu, Philip Johnson, Paul B S Lai
BACKGROUND: Studies comparing microwave ablation (MWA) and liver resection are lacking. This study evaluates the survival of patients with hepatocellular carcinoma (HCC) treated with liver resection or MWA and the role of Albumin-Bilirubin (ALBI) score in patient selection for treatments. METHODS: This is a retrospective analysis of patients who received curative liver resection or MWA for HCC. Propensity score matching was used at a 1:1 ratio. The value of ALBI grade for patient selection was evaluated...
January 15, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29339752/prognostic-performance-of-ten-liver-function-models-in-patients-with-hepatocellular-carcinoma-undergoing-radiofrequency-ablation
#15
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-You Chiou, Chien-Wei Su, Yun-Hsuan Lee, Yi-Hsiang Huang, Fa-Yauh Lee, Ming-Chih Hou, Teh-Ia Huo
Liver functional capacity is a crucial survival determinant for hepatocellular carcinoma (HCC). Noninvasive models were proposed to assess hepatic reserve, but their performance in outcome prediction is unclear. We aimed to investigate 10 currently used liver function models in HCC patients undergoing radiofrequency ablation (RFA). A total 499 HCC patients were prospectively identified. Homogeneity and corrected Akaike information criteria (AICc) were compared. Cox proportional hazards model was used to identify independent survival predictors...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322205/the-role-of-albumin-bilirubin-grade-and-inflammation-based-index-in-patients-with-hepatocellular-carcinoma-treated-with-stereotactic-body-radiotherapy
#16
Eleni Gkika, Dominik Bettinger, Leo Krafft, Michael Schultheiss, Hannes Philipp Neeff, Lars Maruschke, Michaela Schulenburg, Sonja Adebahr, Simon Kirste, Ursula Nestle, Robert Thimme, Anca-Ligia Grosu, Thomas Baptist Brunner
PURPOSE: We evaluated the prognostic accuracy of the albumin-bilirubin (ALBI) grade and the inflammation-based index (IBI) in estimating overall survival (OS) and toxicity in patients with hepatocellular carcinoma (HCC) treated with stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: Forty patients with 47 HCC lesions with a Barcelona Clinic Liver Cancer (BCLC) classification stage B or C were treated with SBRT in 3-12 fractions. The ALBI grade and the IBI were calculated at different time points (baseline, during, at the end of treatment and at follow-up) and compared with the Child-Pugh (CP) score as well as other patient- and treatment-related parameters, concerning OS and toxicity...
January 10, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29317268/combination-of-albumin-bilirubin-grade-and-platelets-to-predict-a-compensated-patient-with-hepatocellular-carcinoma-who-does-not-require-endoscopic-screening-for-esophageal-varices
#17
Ping-Hsien Chen, Wei-Yao Hsieh, Chien-Wei Su, Ming-Chih Hou, Yen-Po Wang, I-Fang Hsin, Tsung-Chieh Yang, Wei-Chih Liao, Han-Chieh Lin, Fa-Yauh Lee, Jaw-Ching Wu
BACKGROUNDS AND AIMS: There is no consensus on screening for high-risk esophageal varices (HRV) in patients with hepatocellular carcinoma (HCC). Here, we aimed to investigate the prevalence and risk factors of HRV in patients with HCC and to assess the combination of albumin-bilirubin grade and platelet count (ALBI-PLT score) for predicting compensated patients who do not need unnecessary endoscopic screening for HRV. METHODS: The ALBI-PLT score was calculated by adding the ALBI grade and points for platelet count (1 point if platelet count >150,000/mm3 and 2 points if ≤150,000/mm3 )...
January 6, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29234641/albi-score-as-a-novel-tool-in-staging-and-treatment-planning-for-hepatocellular-carcinoma-advantage-of-albi-grade-for-universal-assessment-of-hepatic-function
#18
Atsushi Hiraoka, Kojiro Michitaka, Takashi Kumada, Masashi Kudo
No abstract text is available yet for this article.
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234640/albi-score-as-a-novel-tool-in-staging-and-treatment-planning-for-hepatocellular-carcinoma-is-it-sufficient
#19
Teh-Ia Huo, Po-Hong Liu, Chia-Yang Hsu
No abstract text is available yet for this article.
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234636/validation-and-potential-of-albumin-bilirubin-grade-and-prognostication-in-a-nationwide-survey-of-46-681-hepatocellular-carcinoma-patients-in-japan-the-need-for-a-more-detailed-evaluation-of-hepatic-function
#20
Atsushi Hiraoka, Kojiro Michitaka, Takashi Kumada, Namiki Izumi, Masumi Kadoya, Norihiro Kokudo, Shoji Kubo, Yutaka Matsuyama, Osamu Nakashima, Michiie Sakamoto, Tadatoshi Takayama, Takashi Kokudo, Kosuke Kashiwabara, Masatoshi Kudo
Background/Aim: Recently, albumin-bilirubin (ALBI) scoring/grading, consisting of only albumin and total bilirubin, has been proposed. We examined the efficacy of this grading system for determining hepatic function in patients with hepatocellular carcinoma (HCC). Methods/Materials: The prognoses of 46,681 HCC patients based on results obtained from a nationwide survey conducted in Japan from 2001 to 2007 were evaluated using (1) Japan Integrated Staging (JIS), consisting of Child-Pugh classification and TNM staging (TNM), (2) modified JIS (m-JIS), consisting of liver damage grading and TNM, and (3) ALBI-TNM (ALBI-T), consisting of ALBI grading and TNM, and the results were compared...
November 2017: Liver Cancer
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