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https://www.readbyqxmd.com/read/27862671/usefulness-of-albumin-bilirubin-grade-for-evaluation-of-long-term-prognosis-for-hepatitis-b-related-cirrhosis
#1
R-C Chen, Y-J Cai, J-M Wu, X-D Wang, M Song, Y-Q Wang, M-H Zheng, Y-P Chen, Z Lin, K Q Shi
Long-term prognosis varies widely among patients with hepatitis B virus (HBV)-related liver cirrhosis. Our study aimed to investigate the applicability of albumin-bilirubin (ALBI), Child-Pugh and model for end-stage liver disease (MELD) scores to the long-term prognosis prediction of HBV-related cirrhosis. Patients diagnosed with HBV-associated cirrhosis from the First Affiliated Hospital of Wenzhou Medical University between January 2010 and December 2015 were enrolled in this study. The patients were followed up every 3 months...
November 14, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27842668/hepatobiliary-phase-images-using-gadolinium-ethoxybenzyl-diethylenetriamine-penta-acetic-acid-enhanced-mri-as-an-imaging-surrogate-for-the-albumin-bilirubin-grading-system
#2
Yasuo Takatsu, Satoshi Kobayashi, Tosiaki Miyati, Toshiki Shiozaki
OBJECTIVES: To clarify the correlation between hepatobiliary phase (HBP) images using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) and albumin-bilirubin (ALBI) grading system. MATERIALS AND METHODS: We evaluated 220 consecutive patients who underwent liver magnetic resonance imaging with Gd-EOB-DTPA. Quantitative liver-spleen contrast ratio (Q-LSC) was calculated in HBP images approximately 20min after Gd-EOB-DTPA administration. To evaluate the degree of association between Q-LSC and ALBI grade, the Child-Pugh (C-P) score was used for comparison...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27835570/prognostic-nutritional-index-predicts-short-term-outcomes-after-liver-resection-for-hepatocellular-carcinoma-within-the-milan-criteria
#3
Mengyun Ke, Tao Xu, Na Li, Yifan Ren, Aihua Shi, Yi Lv, Haiqi He
BACKGROUND: The prognostic nutritional index (PNI) is calculated based on the serum albumin concentration and the total lymphocyte count. The aim of this study was to investigate the prognostic ability of the PNI for postoperative complications after liver resection to treat hepatocellular carcinoma (HCC) within the Milan criteria. RESULTS: Postoperative complications were observed in 166 (44.6%) patients. The optimal cutoff value of the PNI was set at 45.6 for postoperative complications...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27696519/albi-and-palbi-grade-predict-survival-for-hcc-across-treatment-modalities-and-bclc-stages-in-the-meld-era
#4
Po-Hong Liu, Chia-Yang Hsu, Cheng-Yuan Hsia, Yun-Hsuan Lee, Yi-You Chiou, Yi-Hsiang Huang, Fa-Yauh Lee, Han-Chieh Lin, Ming-Chih Hou, Teh-Ia Huo
BACKGROUND: The severity of liver dysfunction in hepatocellular carcinoma (HCC) is often estimated with Child-Turcotte-Pugh (CTP) classification or model for end-stage liver disease (MELD) score. We aim to investigate the performance of albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grade, which are recently reported to be simple and objective measurements for liver reserve in HCC. METHODS: Between 2002 and 2014, consecutive 3,182 HCC patients were enrolled to follow up their survival...
October 3, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27677714/the-albi-grade-provides-objective-hepatic-reserve-estimation-across-each-bclc-stage-of-hepatocellular-carcinoma
#5
David J Pinato, Rohini Sharma, Elias Allara, Clarence Yen, Tadaaki Arizumi, Keiichi Kubota, Dominik Bettinger, Jeong Won Jang, Carlo Smirne, Young Woon Kim, Masatoshi Kudo, Jessica Howell, Ramya Ramaswami, Michela E Burlone, Vito Guerra, Robert Thimme, Mitsuru Ishizuka, Justin Stebbing, Mario Pirisi, Brian I Carr
BACKGROUND & AIMS: Overall survival (OS) is a composite clinical endpoint in hepatocellular carcinoma due to the mutual influence of cirrhosis and active malignancy in dictating patient's mortality. The ALBI grade is a recently described index of liver dysfunction in HCC, based solely on albumin and bilirubin levels. Whilst accurate, this score lacks cross-validation, especially in intermediate-stage HCC, where OS is highly heterogeneous. METHODS: We evaluated the prognostic accuracy of the ALBI grade in estimating overall survival (OS) in a large, multi-center study including 2426 patients, including a large proportion of intermediate-stage patients treated with chemoembolization (n=1461) accrued from Europe, the United States and Asia...
September 24, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27674053/assessment-of-hepatic-function-decline-after-stereotactic-body-radiation-therapy-for-primary-liver-tumors-using-the-albumin-bilirubin-albi-score
#6
D A S Toesca, E Osmundson, J Shaffer, R von Eyben, A C Koong, D T Chang
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27644664/talin-1-and-non-invasive-fibrosis-models-in-the-assessment-of-patients-with-hepatocellular-carcinoma
#7
Ayman Alsebaey, Eman Aly Ahmedy
BACKGROUND: Hepatocellular carcinoma (HCC) is a dreadful complication of end stage liver disease with high morbidity and mortality. AIM: The aim was to assess the role of serum talin-1 and non-invasive brosis in patients with HCC. MATERIALS AND METHODS: A total of eighty seven subjects were enrolled, with 22 two healthy individuals as a control group (n=22), 22 patients in the cirrhosis group and finally 43 in the group with HCC diagnosed with positive triphasic CT abdomen criteria...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27619809/albumin-bilirubin-score-predicting-short-term-outcomes-including-bile-leak-and-post-hepatectomy-liver-failure-following-hepatic-resection
#8
Nikolaos Andreatos, Neda Amini, Faiz Gani, Georgios A Margonis, Kazunari Sasaki, Vanessa M Thompson, David J Bentrem, Bruce L Hall, Henry A Pitt, Ana Wilson, Timothy M Pawlik
INTRODUCTION: Post-operative bile leak (BL) and post hepatectomy liver failure (PHLF) are the major potential sources of morbidity among patients undergoing liver resection. We sought to define the incidence of BL and PHLF among a large cohort of patients, as well as examine the prognostic impact of model for end-stage liver disease (MELD) and albumin-bilirubin (ALBI) scores to predict these short-term outcomes. MATERIALS AND METHODS: Patients who underwent a hepatectomy between January 1, 2014 and December 31, 2014 were identified using the National Surgical Quality Improvement Program (NSQIP) liver-targeted database...
September 12, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27558521/prognostic-value-of-the-albumin-bilirubin-grade-in-patients-with-hepatocellular-carcinoma-validation-in-a-chinese-cohort
#9
Mu-Xing Li, Hong Zhao, Xin-Yu Bi, Zhi-Yu Li, Zhen Huang, Yue Han, Jian-Guo Zhou, Jian-Jun Zhao, Ye-Fan Zhang, Jian-Qiang Cai
AIM: The prognostic value of the newly raised objective liver function assessment tool, the albumin-bilirubin (ALBI) grade, in patients with hepatocellular carcinoma (HCC) has not been fully validated. We aimed to compare the performance of ALBI grade with the specific Child-Pugh score in predicting the prognosis in this study. METHODS: The clinical data of 491 Child-Pugh class A patients who underwent liver resection as the initial therapy from January 2000 to December 2007 in Cancer Hospital, Chinese Academy of Medical Sciences were retrospectively analyzed...
August 25, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27519630/free-water-elimination-improves-test-retest-reproducibility-of-diffusion-tensor-imaging-indices-in-the-brain-a-longitudinal-multisite-study-of-healthy-elderly-subjects
#10
Angela Albi, Ofer Pasternak, Ludovico Minati, Moira Marizzoni, David Bartrés-Faz, Núria Bargalló, Beatriz Bosch, Paolo Maria Rossini, Camillo Marra, Bernhard Müller, Ute Fiedler, Jens Wiltfang, Luca Roccatagliata, Agnese Picco, Flavio Mariano Nobili, Oliver Blin, Julien Sein, Jean-Philippe Ranjeva, Mira Didic, Stephanie Bombois, Renaud Lopes, Régis Bordet, Hélène Gros-Dagnac, Pierre Payoux, Giada Zoccatelli, Franco Alessandrini, Alberto Beltramello, Antonio Ferretti, Massimo Caulo, Marco Aiello, Carlo Cavaliere, Andrea Soricelli, Lucilla Parnetti, Roberto Tarducci, Piero Floridi, Magda Tsolaki, Manos Constantinidis, Antonios Drevelegas, Giovanni Frisoni, Jorge Jovicich
Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal studies. However, it is not clear if these two models differ in their test-retest reproducibility. This study compares a bi-tensor model for FWE with DTI by extending a previous longitudinal-reproducibility 3T multisite study (10 sites, 7 different scanner models) of 50 healthy elderly participants (55-80 years old) scanned in two sessions at least 1 week apart...
August 13, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27257086/incorporating-albumin-bilirubin-grade-into-the-cancer-of-the-liver-italian-program-system-for-hepatocellular-carcinoma
#11
Anthony W H Chan, Charing C N Chong, Frankie K F Mo, John Wong, Winnie Yeo, Philip J Johnson, Shuangni Yu, Paul B S Lai, Anthony T C Chan, Ka-Fai To, Stephen L Chan
BACKGROUND & AIMS: The albumin-bilirubin (ALBI) grade is a recently emerging alternative of the Child-Pugh (CP) grade. The Cancer of the Liver Italian Program (CLIP) was demonstrated to be a useful prognostic model for hepatocellular carcinoma (HCC) in large prospective cohorts. We aimed to investigate the feasibility of substituting the CP grade by the ALBI grade in the CLIP system and compare the prognostic performance with other existing staging systems. METHODS: A large cohort of 1973 Chinese patients with HCC was recruited to evaluate the prognostic performance of CP-based CLIP (CP-CLIP) and ALBI-based CLIP (ALBI-CLIP) systems and 9 other staging systems by homogeneity likelihood chi-square, c-index and corrected Akaike information criterion (AICc)...
June 2, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27214151/a-multicenter-comparison-between-child-pugh-and-albi-scores-in-patients-treated-with-sorafenib-for-hepatocellular-carcinoma
#12
Julien Edeline, Jean-Frédéric Blanc, Philip Johnson, Boris Campillo-Gimenez, Paul Ross, Yuk Ting Ma, Judy King, Richard A Hubner, Kate Sumpter, Suzanne Darby, Jeff Evans, Chinenye Iwuji, Daniel Swinson, Peter Collins, Kinnari Patel, Iqtedar Muazzam, Daniel H Palmer, Tim Meyer
BACKGROUND & AIMS: The ALBI grade was proposed as an objective means to evaluate liver function in patients with Hepatocellular Carcinoma (HCC). ALBI grade 1 vs 2 were proposed as stratification factors within the Child Pugh (CP) A class. However, the original publication did not provide comparison with the sub-classification by points (5 to 15) within the CP classification. METHODS: We retrospectively analyzed data from patients treated with sorafenib for HCC from 17 centers in United Kingdom and France...
May 23, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27196736/efficacy-of-albis-for-the-prevention-of-gastric-mucosal-injury-concomitant-with-the-use-of-low-dose-aspirin-a-prospective-randomized-placebo-controlled-study
#13
Sang Gyun Kim, Nayoung Kim, Sung Kwan Shin, In Kyung Sung, Su Jin Hong, Hyo-Jin Park
Background/Aims: Long-term use of aspirin can be a risk factor of peptic ulcer diseases. The aim of this study was to evaluate the efficacy of Albis (Daewoong Pharmaceutical Co., Ltd.) for the prevention of gastric mucosal injury caused by aspirin. Methods: Aspirin users were enrolled and randomized into the Albis or placebo group. Screening and follow-up endoscopy were performed for modified Lanza scores (MLSs). Primary outcome was measured by the incidence rate of peptic ulcer, and secondary outcomes were measured by the incidence rate of gastritis, improvement in MLS and subjective symptoms...
May 19, 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/27171388/aberrant-methylation-of-tumour-suppressor-genes-wt1-gata5-and-pax5-in-hepatocellular-carcinoma
#14
Martin Mžik, Marcela Chmelařová, Stanislav John, Jan Laco, Ondřej Slabý, Igor Kiss, Lucia Bohovicová, Vladimír Palička, Jana Nekvindová
BACKGROUND: Aberrant hypermethylation of tumour suppressor genes (TSGs) occurring in hepatocellular carcinoma (HCC) could provide a mean of molecular characterisation of this cancer. The aim of this study was to investigate promoter methylation and gene expression of selected TSGs in HCC to identify candidate genes for further validation as potential biomarkers. METHODS: Methylation-specific multiplex ligation-dependent probe amplification method was used to measure the methylation status of 25 TSGs in 49 HCC samples and 36 corresponding non-cancerous liver tissue samples...
May 12, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27070325/child-pugh-meld-and-albi-scores-for-predicting-the-in-hospital-mortality-in-cirrhotic-patients-with-acute-on-chronic-liver-failure
#15
Ying Peng, Xingshun Qi, Shanhong Tang, Han Deng, Jing Li, Zheng Ning, Junna Dai, Feifei Hou, Jiancheng Zhao, Ran Wang, Xiaozhong Guo
OBJECTIVES: Our study aimed to evaluate the discriminative abilities of Child-Pugh, model for end-stage liver disease (MELD), and albumin-bilirubin (ALBI) scores in predicting the in-hospital mortality in cirrhotic patients with acute-on-chronic liver failure (ACLF). METHODS: Cirrhotic patients with ACLF admitted between 2010 January and 2014 June were retrospectively reviewed. Areas under the receiver operating characteristic curves (AUROCs) with 95% confidence intervals (CIs) were calculated...
August 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27022825/long-term-impact-of-liver-function-on-curative-therapy-for-hepatocellular-carcinoma-application-of-the-albi-grade
#16
Hidenori Toyoda, Paul B S Lai, James O'Beirne, Charing C Chong, Sarah Berhane, Helen Reeves, Derek Manas, Richard P Fox, Winnie Yeo, Frankie Mo, Anthony W H Chan, Toshifumi Tada, Mercedes Iñarrairaegui, Arndt Vogel, Nora Schweitzer, Stephen L Chan, Bruno Sangro, Takashi Kumada, Philip J Johnson
BACKGROUND: Application of curative therapy for hepatocellular carcinoma is crucially dependent on underlying liver function. Using the recently described ALBI grade we examined the long-term impact of liver dysfunction on survival of early-stage hepatocellular carcinoma (HCC) patients. METHODS: This cohort study comprised 2559 HCC patients from different geographic regions, all treated with curative intent. We also examined the relation between indocyanine green (ICG) clearance and ALBI score...
March 29, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27015623/albumin-bilirubin-score-for-predicting-the-in-hospital-mortality-of-acute-upper-gastrointestinal-bleeding-in-liver-cirrhosis-a-retrospective-study
#17
Deli Zou, Xingshun Qi, Cuihong Zhu, Zheng Ning, Feifei Hou, Jiancheng Zhao, Ying Peng, Jing Li, Han Deng, Xiaozhong Guo
BACKGROUND/AIMS: The albumin-bilirubin (ALBI) score is a new model for assessing the severity of liver dysfunction. In the present study, we aimed to retrospectively compare the performance of ALBI with Child-Pugh and the model for end-stage liver disease (MELD) scores for predicting the in-hospital mortality of acute gastrointestinal bleeding (AUGIB) in liver cirrhosis. MATERIALS AND METHODS: All cirrhotic patients with AUGIB were eligible, provided they had the data needed to determine the ALBI score...
March 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27005482/albumin-bilirubin-versus-child-pugh-score-as-a-predictor-of-outcome-after-liver-resection-for-hepatocellular-carcinoma
#18
Y-Y Wang, J-H Zhong, Z-Y Su, J-F Huang, S-D Lu, B-D Xiang, L Ma, L-N Qi, B-N Ou, L-Q Li
BACKGROUND: The Child-Pugh (CP) score is used widely to assess liver function and predict postoperative outcomes in patients with hepatocellular carcinoma (HCC). Recently, the albumin-bilirubin (ALBI) score has been validated as a predictor of overall survival in these patients. This study aimed to compare the ability of the ALBI and CP scores to predict outcomes in patients with HCC after liver resection with curative intent. METHODS: Consecutive patients who underwent liver resection with curative intent for HCC between January 2007 and July 2013 were included in this retrospective study...
March 23, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/26992142/applicability-of-albumin-bilirubin-based-japan-integrated-staging-albi-t-score-in-hepatitis-b-associated-hepatocellular-carcinoma
#19
Anthony W H Chan, Charing C N Chong, Frankie K F Mo, John Wong, Winnie Yeo, Philip J Johnson, Shuangni Yu, Paul B S Lai, Anthony T C Chan, Ka-Fai To, Stephen L Chan
BACKGROUND & AIMS: The Japan Integrated Staging (JIS) for hepatocellular carcinoma (HCC) has been extensively studied in hepatitis virus C-endemic Japanese population but seldom evaluated outside Japan, while Albumin-Bilirubin (ALBI)-based JIS (ALBI-T) has never been externally validated. We evaluate the prognostic significance of the ALBI-T score among Chinese patients with hepatitis virus B (HBV)-related HCC, and to explore its potential therapeutic application in selecting patients for appropriate treatments in addition to the Barcelona Clinic Liver Cancer (BCLC) recommendation...
March 15, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26860846/modified-clip-with-objective-liver-reserve-assessment-retains-prognosis-prediction-for-patients-with-advanced-hepatocellular-carcinoma
#20
Yu-Yun Shao, Tsung-Hao Liu, Ying-Hui Lee, Chih-Hung Hsu, Ann-Lii Cheng
BACKGROUND AND AIM: The Cancer of the Liver Italian Program (CLIP) score is a commonly used staging system for hepatocellular carcinoma (HCC) helpful with predicting prognosis of advanced HCC. CLIP uses the Child-Turcotte-Pugh (CTP) score to evaluate liver reserve. A new scoring system, the albumin-bilirubin (ALBI) grade, has been proposed as they objectively evaluate liver reserve. We examined whether the modification of CLIP with ALBI retained its prognosis prediction for patients with advanced HCC...
July 2016: Journal of Gastroenterology and Hepatology
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