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https://www.readbyqxmd.com/read/29905933/the-classification-of-pediatric-and-young-adult-renal-cell-carcinomas-registered-on-the-children-s-oncology-group-cog-protocol-aren03b2-after-focused-genetic-testing
#1
Mariana M Cajaiba, Lisa M Dyer, James I Geller, Lawrence J Jennings, David George, Dawn Kirschmann, Stephen M Rohan, Nicholas G Cost, Geetika Khanna, Elizabeth A Mullen, Jeffrey S Dome, Conrad V Fernandez, Elizabeth J Perlman
BACKGROUND: Renal cell carcinomas (RCCs) are rare in young patients. Knowledge of their pathologic and molecular spectrum remains limited, and no prospective studies have been performed to date in this population. This study analyzes patients diagnosed with RCC who were prospectively enrolled in the AREN03B2 Children's Oncology Group (COG). The objective was to classify these tumors with the aid of focused genetic testing and to characterize their features. METHODS: All tumors registered as RCC by central review were retrospectively re-reviewed and underwent additional ancillary studies...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29905543/importance-of-isolated-gestational-hypothyroxinemia-in-the-development-of-obstetric-and-somatic-pathologies
#2
N Morchiladze, B Tkeshelashvili, T Gagua, D Gagua
The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period. Aim of the study was to define the importance of isolated hypothyroxinemia in the development of obstetric and somatic pathologies in outpatient population of pregnant females. The study of prospective design was performed at the base of "David Gagua Clinic" Ltd...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29901633/primary-small-cell-carcinoma-of-the-ureter-case-report-and-review-of-the-literature
#3
Fabiola Farci, Francesca Manassero, Ramona Baldesi, Annamaria Bartolucci, Laura Boldrini, Cesare Selli, Pinuccia Faviana
RATIONALE: Primitive small cell carcinoma of the ureter is extremely rare, in this case report is meticulously described its aggressive clinical course and the pathological clues that help with the diagnosis. Also, a detailed table with the clinico-pathological features of analogous case reports in literature is provided. PATIENT CONCERNS: A 79-year-old female presented with gross hematuria and flank pain. DIAGNOSES: Small cell carcinoma of the ureter...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901149/diagnostic-value-and-lymph-node-metastasis-prediction-of-a-custom%C3%A2-made-panel-thyroline-in-thyroid-cancer
#4
Zunfu Ke, Yihao Liu, Yunjian Zhang, Jie Li, Ming Kuang, Sui Peng, Jinyu Liang, Shuang Yu, Lei Su, Lili Chen, Cong Sun, Bin Li, Jessica Cao, Weiming Lv, Haipeng Xiao
Differentiation of benign and malignant thyroid nodules is crucial for clinical management. Here, we explored the efficacy of next‑generation sequencing (NGS) in predicting the classification of benign and malignant thyroid nodules and lymph node metastasis status, and simultaneously compared the results with ultrasound (US). Thyroline was designed to detect 15 target gene mutations and 2 fusions in 98 formalin‑fixed, paraffin‑embedded (FFPE) tissues, including those from 82 thyroid cancer (TC) patients and 16 patients with benign nodules...
June 14, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29900122/proteomic-analysis-reveals-differential-protein-expression-in-variants-of-papillary-thyroid-carcinoma
#5
Yasemin Ucal, Murat Eravci, Fatma Tokat, Mete Duren, Umit Ince, Aysel Ozpinar
Introduction: Fine Needle Aspiration Biopsy (FNAB) allows the cytological differentiation of benign and malignant thyroid nodules. However, the method itself is not adequate in determining some cases. For example, the diagnosis of Follicular Variant Papillary Thyroid Carcinoma (FV-PTC) can be challenging. In the current study we investigate the protein profiles of FV-PTC and classical variant PTC (CV-PTC) with no lymph node metastasis and compare it with benign thyroid tissue. Method: We used CV-PTC (n = 6), FV-PTC (n = 6) and benign thyroid tissues (n = 6) to prepare tissue lysates...
December 2017: EuPA Open Proteomics
https://www.readbyqxmd.com/read/29897018/-b-predicting-malignancy-in-thyroid-nodules-radiomics-score-versus-2017-american-college-of-radiology-acr-thyroid-imaging-reporting-and-data-system-ti-rads-b
#6
Jin-Yu Liang, Xiao-Wen Huang, Hang-Tong Hu, Yi-Hao Liu, Qian Zhou, Qing-Hua Cao, Wei Wang, Bao-Xian Liu, Yan-Ling Zheng, Xin Li, Xiao-Yan Xie, Ming-de Lu, Sui Peng, Long-Zhong Liu, Haipeng Xiao
<b>Background</b> Visual interpretation of ultrasound (US) images alone may not be sensitive enough to detect important features of potentially malignant thyroid nodules. The aim of this study was to develop a radiomics score using US imaging to predict the probability for malignancy of thyroid nodules as compared with the Thyroid Imaging, Reporting and Data System (TI-RADS) scoring criteria proposed by the American College of Radiology (ACR). <b>Methods</b> One hundred thirty-seven pathologically proven thyroid nodules from hospital #1 were enrolled as a training cohort while 95 nodules from hospital #2 served as the validation cohort...
June 13, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29896255/therapeutic-effects-of-acupuncture-with-mok-a-polyherbal-medicine-on-ptu-induced-hypothyroidism-in-rats
#7
Ji Hye Hwang, Hyo Won Jung, Seok Yong Kang, An Na Kang, Jun Nan Ma, Xiang Long Meng, Min Sub Hwang, Yong-Ki Park
Acupuncture with MOK, a polyherbal medicine (MOK pharmacopuncture), has been used for the treatment of thyroid syndromes including hypothyroidism and hyperthyroidism in traditional Korean medicine. The present study investigated the effect of MOK pharmacopuncture on hypothyroidism and the mechanism underlying its antioxidation and immune regulation effects. Hypothyroidism was induced in Sprague-Dawley rats by subcutaneous injection of Propylthiouracil (PTU; 10 mg/kg) once daily for 4 weeks. MOK was administered by acupuncture on the acupoints around the thyroid gland of PTU-induced hypothyroidism rats once daily for 2 weeks following hypothyroidism induction...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29891396/management-of-thyroid-gland-abscess
#8
Javier García Callejo, Jaume Redondo Martínez, Miguel Civera, José Verdú Colomina, Verónica Pellicer Zoghbi, M Paz Martínez Beneyto
BACKGROUND: Thyroid abscess or acute suppurative thyroiditis is an unusual clinical condition. We present our experience with cases attended over 41 years. MATERIALS AND METHODS: A retrospective study was performed on these patients reviewing their epidemiological characteristics and the diagnostic and therapeutic manoeuvres chosen for them all, as well as their clinical outcome. A group of 9 males and 5 females was studied, with ages ranging from 19 to 68 (mean of 40...
June 8, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29890543/the-role-of-different-molecular-markers-in-papillary-thyroid-cancer-patients-with-acromegaly
#9
Fatma Ela Keskin, Hande Mefkure Ozkaya, Sina Ferahman, Ozlem Haliloglu, Adem Karatas, Figen Aksoy, Pinar Kadioglu
PURPOSE: Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules. METHODS: We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29879058/usefulness-of-preoperative-ultrasonographic-localization-for-diagnosis-of-a-rare-disease-intrathyroid-parathyroid-lesions
#10
Tiantian Ye, Xuepei Huang, Yu Xia, Li Ma, Liang Wang, Xingjian Lai, He Liu, Bo Zhang, Ke Lv, Li Huo, Ya Hu, Quan Liao, Yuxin Jiang
The aim of this article is to explore the value of ultrasonic diagnosis and localization of intrathyroid parathyroid diseases.The medical records of 15 patients with surgically confirmed intrathyroid parathyroid diseases were reviewed. We analyzed the diagnosis process and recorded sonographic features of these intrathyroid parathyroid lesions.The patients included 11 females (73%, 11/15) and 4 males (27%, 4/15) with a mean age of 46.2 ± 10.2 years and a mean lesion size of 2.1 ± 1.1 cm. A total of 11 intrathyroid parathyroid lesions in this study presented as hypoechoic (73...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29877611/highly-specific-preoperative-selection-of-solitary-parathyroid-adenoma-cases-in-primary-hyperparathyroidism-by-quantitative-image-analysis-of-the-early-phase-technetium-99m-sestamibi-scan
#11
DaeHee Kim, Jeffrey A Rhodes, Jeffrey A Hashim, Lawrence Rickabaugh, David M Brams, Edward Pinkus, Yamin Dou
INTRODUCTION: Highly specific preoperative localizing test is required to select patients for minimally invasive parathyroidectomy (MIP) in lieu of traditional four-gland exploration. We hypothesized that Tc-99m sestamibi scan interpretation incorporating numerical measurements on the degree of asymmetrical activity from bilateral thyroid beds can be useful in localizing single adenoma for MIP. METHODS: We devised a quantitative interpretation method for Tc-99m sestamibi scan based on the numerically graded asymmetrical activity on early phase...
June 7, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29876020/thyroid-function-in-the-etiology-of-fatigue-in-breast-cancer
#12
Nagi B Kumar, Angelina Fink, Silvina Levis, Ping Xu, Roy Tamura, Jeffrey Krischer
Background: Cancer related fatigue (CRF), reported in about 90% of breast cancer patients receiving chemotherapy, and has a profound impact on physical function, psychological distress and quality of life. Although several etiological factors such as anemia, depression, chronic inflammation, neurological pathology and alterations in metabolism have been proposed, the mechanisms of CRF are largely unknown. Methods: We conducted a pilot, prospective, case-control study to estimate the magnitude of change in thyroid function in breast cancer patients from baseline to 24 months, compared to cancer-free, age-matched controls...
May 22, 2018: Oncotarget
https://www.readbyqxmd.com/read/29862999/retinoid-receptor-related-orphan-receptor-alpha-a-key-gene-setting-brain-circuits
#13
Tania Vitalis, Jean Mariani
The retinoid receptor-related orphan receptor alpha (RORα) is thought to act as a constitutive activator of transcription by binding to the ROR response element (RORE) of target genes. Several mouse models in which RORα is defective have revealed the decisive roles of RORα on the development, maturation and neuroprotection of various cerebral regions including the cerebellar and somatosensory systems. We have recently shown that RORα is needed for accurate thalamic sensory system organization and somatosensory cortex development...
May 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29858862/pretibial-myxedema-in-a-euthyroid-patient
#14
REVIEW
Panagiotis Anagnostis, Aikaterini Artzouchaltzi, Alexandra Grekou, Stavroula A Paschou, Spyridon Gerou, Vasilios Tzalokostas
Pretibial myxedema (PM) is a rare extrathyroidal manifestation of Graves' disease (GD), usually during the hyperthyroid state, coexisting with orbitopathy. We describe a rare case of a biopsy-proven PM in a euthyroid patient, without history of GD or Hashimoto's thyroiditis. Assessment of commonly reported thyroid autoantibodies, such as thyroid peroxidase and thyroglobulin autoantibodies, thyroid stimulating immunoglobulins and thyroid binding inhibitory immunoglobulins, was negative. Resolution of skin pathology was achieved after topical application of corticosteroids and was sustained 1 year later...
March 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29858848/subclinical-hypothyroidism-new-trials-old-caveats
#15
REVIEW
Faiza Lamine, Sara De Giorgi, Laura Marino, Marina Michalaki, Gerasimos P Sykiotis
The indications for levothyroxine replacement therapy for subclinical hypothyroidism (SH) remain a subject of debate, especially when prescribed for older adults. The results of the recent TRUST trial indicate that levothyroxine does not improve clinical symptom scores among elderly patients with SH. While there is much concern regarding the dilemma of introducing or withholding levothyroxine, less attention may be paid to the differential diagnosis of an elevated TSH level, which is the prerequisite for diagnosing SH...
April 27, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29850289/a-novel-ret-d898y-germline-mutation-in-a-patient-with-pheochromocytoma
#16
Jin Wook Yi, Hye In Kang, Su-Jin Kim, Chan Yong Seong, Young Jun Chai, June Young Choi, Moon-Woo Seong, Kyu Eun Lee, Sung Sup Park
Pheochromocytoma and paraganglioma are tumors of neuroectoderm origin. Up to 40% of patients with these tumors have germline mutations in known susceptibility genes. We report a novel RET germline mutation (exon 15; c.2692G>T (D898Y)) in a pheochromocytoma patient, as well as in her two asymptomatic sons and older sister. A 49-year-old female came to our clinic presenting with a right adrenal gland mass detected during a healthcare examination. Her mother and two sisters had previously undergone thyroidectomy for papillary thyroid carcinomas...
2018: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29850012/significance-of-testing-anti-thyroid-autoantibodies-in-patients-with-deranged-thyroid-profile
#17
Hamid Nawaz Tipu, Dawood Ahmed, Muhammad Mukarram Bashir, Naveed Asif
Background: We hypothesized that anti-thyroid antibodies are more often positive in individuals with deranged thyroid profile. Methods: This prospective cohort was done in Immunology Department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from Jan 2017 to Oct 2017. All the samples that were referred to us for testing anti-thyroid antibodies (anti-TPO or anti-TG antibodies) and thyroid profile were included in the study. There were no exclusion criteria...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29850011/diagnostic-accuracy-of-preoperative-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-in-detecting-occult-papillary-thyroid-microcarcinomas-in-benign-multinodular-goitres
#18
Dimitrios K Manatakis, Sophia Tseleni-Balafouta, Lazaros Tzelves, Dimitrios Balalis, Adelais Tzortzopoulou, Dimitrios P Korkolis, George H Sakorafas, Emmanouil Gontikakis, Georgios Plataniotis
Objective: To investigate the diagnostic accuracy of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios in detecting occult papillary thyroid microcarcinomas in benign, multinodular goitres. Methods: 397 total thyroidectomy patients were identified from the institutional thyroid surgery database between 2007 and 2016 (94 males, 303 females, mean age 53 ± 14.5 years). NLR and PLR were calculated as the absolute neutrophil and absolute platelet counts divided by the absolute lymphocyte count, respectively, based on the preoperative complete blood cell count...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29849975/mucocele-of-the-dorsal-surface-of-the-tongue-a-case-report
#19
Savvas Titsinides, Demos Kalyvas, Konstantinos Tosios
Mucoceles represent one of the most common lesions of the oral cavity, developing as a result of saliva accumulation. The most frequent affected area is the lower lip, followed by floor of mouth, ventral tongue and buccal mucosa. Despite numerous reports of mucoceles originating on the ventral surface of the tongue, only scarce cases of such a lesion identified on the dorsal tongue surface have been described. In this report a mucocele developed on the dorsal tongue of a 74-year-old woman is described. Additionally a review of previously published mucoceles of the dorsal surface of the tongue is provided and discussed...
May 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29848886/association-of-the-polymorphisms-in-th2-chemotaxis-related-genes-with-the-development-and-prognosis-of-autoimmune-thyroid-diseases
#20
Naoki Omori, Mikio Watanabe, Naoya Inoue, Junpei Taniguchi, Yoh Hidaka, Yoshinori Iwatani
The prognosis of autoimmune thyroid disease (AITD) is difficult to predict. Th2 cells suppress the differentiation of Th1 and Th17 cells, which are associated with the prognosis of AITD. However, there are few reports as to whether Th2 chemotaxis-related genes, such as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), IL-25, TARC/CCL17 (Thymus and activation regulated chemokine/chemokine ligand 17) or STAT6 (Signal transducer and activator of transcription 6), affect the pathology of and/or susceptibility to AITD...
May 30, 2018: Endocrine Journal
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