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https://www.readbyqxmd.com/read/29052599/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-a-review-for-pathologists
#1
REVIEW
Raja R Seethala, Zubair W Baloch, Justine A Barletta, Elham Khanafshar, Ozgur Mete, Peter M Sadow, Virginia A LiVolsi, Yuri E Nikiforov, Giovanni Tallini, Lester Dr Thompson
The rising incidence of papillary thyroid carcinoma is linked in part to inclusion of noninvasive follicular variant of papillary thyroid carcinoma. Despite its designation as carcinoma, noninvasive follicular variant of papillary thyroid carcinoma appears to be exceptionally indolent, often over treated by current treatment practices. Additionally, criteria for diagnosis have historically been subjective and challenging. Recently, an international multidisciplinary collaborative group performed a clinicopathologic survey of such cases with extended follow-up and concluded based on the outcome data that a revision in nomenclature was warranted, proposing 'Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP)...
October 20, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29050166/-clinic-pathological-and-ultrasonographic-features-of-primary-thyroid-lymphoma
#2
X M Zhang, L Nong, X Ran, M Li
Objective: To analyze the ultrasonographic and clinicopathological features of primary thyroid lymphoma(PTL). Methods: The ultrasonographic and clinicopathological featuresof 21 cases of pathologically-confirmed PTLs were analyzed retrospectively. Results: Of all 21 PTLs, 15 cases were diffuse large B-cell lymphoma, 4 were mucosal-associated lymphoid tissue extranodular marginal zone B-cell lymphoma, 1 was small B-cell lymphoma and 1 was classical Hodgkin lymphoma. Eight cases were proved by pathology with concomitant Hashimoto's thyroiditis...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29048684/mir-146a-and-mir-146b-in-the-diagnosis-and-prognosis-of-papillary-thyroid-carcinoma
#3
Zhenwei Qiu, Hai Li, Jianwei Wang, Chongbing Sun
The present study investigated the relationship between the expression of miR-146a and miR‑146b with the occurrence and prognosis of papillary thyroid carcinoma. Experiments in vitro were also used to explore the effect of the knocked down expression of the miRNAs on growth and migration of papillary thyroid carcinoma cells. A total of 73 patients with papillary thyroid carcinoma admitted to Yidu Central Hospital of Weifang from September 2013 to September 2015 were enrolled in the study. Carcinoma samples were obtained from each patient, and adjacent tissues were used as control samples to determine expression levels of miR-146a and miR146b by semi-quantitative RT-PCR...
September 25, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048269/an-improved-collagen-zymography-approach-for-evaluating-the-collagenases-mmp-1-mmp-8-and-mmp-13
#4
Seniz Inanc, Didem Keles, Gulgun Oktay
Collagen zymography is an SDS-PAGE-based method for detecting both the proenzyme and active forms of collagenases. Although collagen zymography is used for assessment of the matrix metalloproteinases MMP-1 and MMP-13, it can be difficult to detect these collagenases due to technical issues. Moreover, it remains unclear whether the collagenase activity of MMP-8 can be detected by this method. Here, we present an improved collagen zymography method that allows quantification of the activities of MMP-1, MMP-8, and MMP-13...
October 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/29046513/history-and-practice-of-thyroid-fine-needle-aspiration-in-china-based-on-retrospective-study-of-the-practice-in-shandong-university-qilu-hospital
#5
Zhiyan Liu, Dongge Liu, Bowen Ma, Xiaofang Zhang, Peng Su, Li Chen, Qingdong Zeng
Cytology in China developed from nothing and underwent a long journey from gynecologic cytology to that of all organs, laying a solid foundation for new developments in the 21st century. Thyroid fine-needle aspiration (FNA) was primarily developed in an endocrinology department and then in the clinical laboratory department or pathology department in the 1970-80s. Wrights staining is popular in endocrine and clinical laboratory departments, while hematoxylin and eosin staining is common in pathology. Liquid based cytology is not common in thyroid FNA cytology, while BRAFV600E mutation analysis has been the most popular molecular test...
October 19, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29039351/epidemiology-risk-factors-and-prognosis-of-interferon-alpha-induced-thyroid-disorders-a-prospective-clinical-study
#6
Łukasz Obołończyk, Małgorzata Siekierska-Hellmann, Piotr Wiśniewski, Anna Lewczuk, Monika Berendt-Obołończyk, Anna Lakomy, Zofia Michalska, Danuta Radowska, Grażyna Moszkowska, Agnieszka Bianek-Bodzak, Krzysztof Sworczak
INTRODUCTION: Hepatitis C virus (HCV) infection is a worldwide problem and hepatitis, which is its natural unfavourable course, is still a challenge for hepatologist. At present, standards of treatment are changing from combined therapy with interferon alpha (IFN-α) and ribavirin to new antiviral drugs. The current classification divides interferon induced thyroid diseases (IITD) into two groups: autoimmune (Hashimoto disease, Graves disease, positive antithyroid autoantibodies in euthyroid patients) and non-autoimmune (destructive thyroiditis, non-autoimmune hypothyroidism)...
September 25, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29038858/surgical-management-of-primary-hyperparathyroidism
#7
Stephen Ryan, Danielle Courtney, Julia Moriariu, Conrad Timon
We reviewed the surgical management of primary hyperparathyroidism through a retrospective chart review of 200 parathyroidectomy procedures performed over a 12 year period. Epidemiological data and accuracy of radiological investigations used in identifying pathological parathyroid tissue location were assessed. We determined how often simultaneous removal of thyroid tissue was required during parathyroidectomy and the associated pathology. Radiology reports were screened to determine if confirmed thyroid pathology from histological specimens were referenced pre-operatively...
October 16, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29033443/signet-ring-cell-carcinoma-of-unknown-primary-origin-detected-incidentally-by-lymph-node-purification-for-thyroid-carcinoma
#8
Hideo Handa, Daisuke Gomi, Toshirou Fukushima, Takashi Kobayashi, Nodoka Sekiguchi, Akiyuki Sakamoto, Yoshiko Tsukahara, Hirohide Matsushita, Shigeru Sasaki, Keiko Mamiya, Tomonobu Koizumi, Takashi Ichiyama
A 63-year-old woman underwent thyroidectomy for papillary thyroid adenocarcinoma and cervical lymph node resection. Pathological analyses revealed the presence of signet cell carcinoma in a resected lymph node, which were apparently different from the pathological findings of thyroid carcinoma. No evidence of a primary tumor could be found elsewhere despite detailed examinations, including esophagogastroduodenoscopy, colonoscopy, capsule endoscopy, CT scan, and fluorodeoxyglucose-positron emission tomography...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29024469/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-in-the-pediatric-age-group
#9
Esther Diana Rossi, Swati Mehrotra, Ayse Irem Kilic, Iclal Erdem Toslak, Jennifer Lim-Dunham, Maurizio Martini, Guido Fadda, Celestino Pio Lombardi, Luigi Maria Larocca, Güliz A Barkan
BACKGROUND: The most common malignant thyroid neoplasm in children is papillary thyroid carcinoma (PTC). In 2015, the Endocrine Pathology Society introduced the terminology "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) to replace the noninvasive follicular variant of PTC. The objective of the current study was to evaluate previously diagnosed PTC in the pediatric population, reappraise it for NIFTP, and discuss the impact of NIFTP on the risk of malignancy (ROM) for each The Bethesda System for Reporting Thyroid Cytopathology category in the pediatric population...
October 12, 2017: Cancer
https://www.readbyqxmd.com/read/29024261/pathologic-significance-of-a-novel-oncoprotein-in-thyroid-cancer-progression
#10
Anthony A Firek, Mia C Perez, Amber Gonda, Li Lei, Iqbal Munir, Alfred A Simental, Frances E Carr, Benjamin J Becerra, Marino De Leon, Salma Khan
BACKGROUND: The incidence of thyroid cancer is increasing worldwide, and there is an emerging need to develop accurate tools for diagnosis. Fine needle aspiration biopsy has greatly improved evaluation of thyroid nodules, but challenges with indeterminate lesions remain in up to 25% of biopsies. Novel tissue biomarkers may assist in improved nodule characterization. Microcalcifications occurring in thyroid cancers suggest proteins involved in bone formation may play a role in thyroid carcinogenesis...
October 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/29023564/large-%C3%A2-3cm-thyroid-nodules-with-benign-cytology-can-thyroid-imaging-reporting-and-data-system-tirads-help-predict-false-negative-cytology
#11
Se Jin Nam, Jin Young Kwak, Hee Jung Moon, Jung Hyun Yoon, Eun-Kyung Kim, Ja Seung Koo
BACKGROUND: There is controversy about the accuracy of the fine-needle aspiration (FNA) cytology results in large sized thyroid nodules. Our aim was to evaluate the false-negative rate of FNA for large thyroid nodules and the usefulness of the Thyroid Imaging Reporting and Data System (TIRADS) in predicting false-negative cytology for large thyroid nodules with benign cytology. METHODS: 632 thyroid nodules larger than or equal to 3cm in size with subsequent benign cytology on US-guided FNA were included...
2017: PloS One
https://www.readbyqxmd.com/read/29023300/thyroglossal-duct-cyst-at-the-base-of-tongue-the-emerging-role-of-transoral-endoscopic-assisted-surgery
#12
Mario Turri-Zanoni, Paolo Battaglia, Paolo Castelnuovo
Cystic lesions involving the tongue base are rare, generally presenting in pediatric patients, and they may encompass different pathologies such as ranula, lingual ectopic thyroid, thyroglossal duct cyst (TDC), dysontogenetic cysts, benign, and malignant tumors.This paper describes the case of a 19-year-old girl with phonation impairment and mild dysphagia due to limited tongue protrusion and movements. Radiologic examinations revealed a bulky cystic lesion at the base of tongue with displacement of extrinsic lingual muscles...
October 11, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29020892/are-evidence-based-guidelines-reflected-in-clinical-practice-an-analysis-of-prospectively-collected-data-of-the-italian-thyroid-cancer-observatory-itco-1
#13
Livia Lamartina, Cosimo Durante, Giuseppe Lucisano, Giorgio Grani, Rocco Alfonso Bellantone, Celestino Pio Lombardi, Alfredo Pontecorvi, Emanuela Arvat, Francesco Felicetti, Maria Chiara Zatelli, Roberta Rossi, Efisio Puxeddu, Silvia Morelli, Massimo Torlontano, Umberto Crocetti, Teresa Montesano, Raffaele Giubbini, Fabio Orlandi, Gianluca Aimaretti, Fabio Monzani, Marco Attard, Cecilia Francese, Alessandro Antonelli, Paolo P Limone, Ruth Rossetto, Laura Fugazzola, Domenico Meringolo, Rocco Bruno, Salvatore Tumino, Graziano Ceresini, Marco Centanni, Salvatore Monti, Domenico Salvatore, Caterina Mian, Giovanna Spiazzi, Luca Persani, Daniele Barbaro, Antonio Nicolucci, Sebastiano Filetti
OBJECTIVES: The goal of evidence-based practice guidelines is to optimize the management of emerging diseases, such as differentiated thyroid cancer (DTC). The aim of this study was to assess therapeutic approaches for DTC in Italy and to see how closely these practices conformed to those recommended in the 2009 American Thyroid Association (ATA) guidelines. METHODS: The Italian Thyroid Cancer Observatory (ITCO) was established to prospectively collect data on thyroid cancers consecutively diagnosed in participating centers (uniformly distributed across the nation)...
October 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29020884/pathologic-reporting-of-tall-cell-variant-of-papillary-thyroid-cancer-have-we-reached-a-consensus
#14
Juan Hernandez-Prera, Rosalie Machado, Sylvia L Asa, Zubair W Baloch, William C Faquin, Ronald Ghossein, Virginia A LiVolsi, Ricardo V Lloyd, Ozgur Mete, Yuri E Nikiforov, Raja Seethala, Saul Suster, Lester D R Thompson, Andrew Turk, Peter M Sadow, Mark L Urken, Bruce M Wenig
BACKGROUND: Tall cell variant (TCV) is widely believed to be a more aggressive subtype of papillary thyroid carcinoma (PTC). Despite the significance of TCV with respect to risk stratification and therapeutic decision making, its diagnosis is subject to interobserver variability. We aim to determine the level of agreement among expert pathologists in the identification and reporting of TCV. METHODS: 17 surgical resections for thyroid cancer containing the diagnostic term "tall cell" in their pathology reports and 22 cases diagnosed as classical PTC were selected...
October 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29019888/an-upper-cervical-cord-compression-secondary-to-occult-follicular-thyroid-carcinoma-metastases-successfully-treated-with-multiple-radioiodine-therapies-a-clinical-case-report
#15
Ping Dong, Ni Chen, Lin Li, Rui Huang
RATIONALE: The spine is the most common site of bone metastases due to thyroid cancer; however, spinal cord compression as a complication of metastatic thyroid cancer is very rare. PATIENT CONCERNS: A 48-year-old female patient was presented to the Neurosurgical Department, complaining of progressive back neck pain with bilateral upper extremities numbness and weakness for 4 months. DIAGNOSIS: Imaging studies revealed osteolytic destruction in bodies and accessories of the second and third cervical vertebrae with a huge soft-tissue mass compressing spinal cord and causing swelling...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29019001/anaplastic-thyroid-cancer-and-hyperfractionated-accelerated-radiotherapy-hart-with-and-without-surgery
#16
Anne-Birgitte Jacobsen, Krystyna K Grøholt, Bianca Lorntzsen, Terje A Osnes, Ragnhild Sørum Falk, Eva Sigstad
Anaplastic carcinoma of the thyroid gland (ATC) is one of the most aggressive cancers in humans. With insufficient treatment, the disease most often leads to death in suffocation. From 2002, our treatment strategy has been hyperfractionated accelerated radiotherapy (HART) with high doses (64 Gy) to the neck, followed by surgery 4-8 weeks later if feasible, with the aim to gain control in the neck. After a pathology review, 51 patients were diagnosed with ATC in the period 2002-2014 in the south-east of Norway...
October 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29017314/thyroid-fine-needle-aspiration-cytology-practice-in-korea
#17
Yoon Jin Cha, Ju Yeon Pyo, Soon Won Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, KyuengWhan Min, Soonae Oak, Sunhee Chang
We reviewed the current status of thyroid fine needle aspiration cytology (FNAC) in Korea. Thyroid aspiration biopsy was first introduced in Korea in 1977. Currently, radiologists aspirate the thyroid nodule under the guidance of ultrasonography, and cytologic interpretation is only legally approved when a cytopathologist makes the diagnosis. In 2008, eight thyroid-related societies came together to form the Korean Thyroid Association. The Korean Society for Cytopathology and the endocrine pathology study group of the Korean Society for Pathologist have been updating the cytologic diagnostic guidelines...
October 11, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28990674/the-futility-of-intraoperative-frozen-section-in-the-evaluation-of-follicular-thyroid-lesions
#18
Craig A Bollig, David Lesko, David Gilley, Laura M Dooley
OBJECTIVE: Investigate the utility of intraoperative frozen section (iFS) in patients with follicular thyroid lesions following publication of the 2015 American Thyroid Association (ATA) guidelines. STUDY DESIGN: Retrospective chart review. METHODS: Patient demographics, preoperative cytology, frozen pathology, and final pathology were reviewed on patients undergoing thyroid surgery at a tertiary care hospital in which iFS was utilized over a 5-year period...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990528/level-v-metastasis-a-novel-predicative-factor-for-recurrence-in-n1b-papillary-thyroid-carcinoma
#19
Yifeng Wu, Jianjun Li, Xianjiang Wu, Lei Dai
BACKGROUND: Lymph nodal (LN) metastasis classified as pN1b is considered as an independent poor prognostic factor for Papillary thyroid carcinoma (PTC) patients. However, whether LN metastasis can serve as a predictive factor for recurrence or disease-free survival of N1b PTC is still plagued by controversy. METHODS: The N1b PTC patients who underwent total thyroidectomy and unilateral modified radical neck dissection (MRND) by the same surgical team in Ningbo NO...
October 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28988447/online-and-call-center-referral-for-endocrine-surgical-pathology-within-institutions
#20
Vaninder K Dhillon, Mai G Al Khadem, Ralph P Tufano, Jonathon O Russell
OBJECTIVES/HYPOTHESIS: We hypothesized that self-referred patients to academic centers will be equally distributed between general surgery and otolaryngology departments that perform thyroid surgery. We sought to quantify disparities in the assignment of these self-referred patients who may reach an institution through call centers or online pathways. STUDY DESIGN: Cross-sectional survey. METHODS: Key words "thyroid surgery" and "thyroid cancer" were used along with the name of the Accreditation Council for Graduate Medical Education-listed otolaryngology program in both Google and Bing search engines...
October 8, 2017: Laryngoscope
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