Silvia González-Martínez, Viera Horvathova Kajabova, Belén Pérez-Mies, Irene Carretero-Barrio, Tamara Caniego-Casas, David Sarrió, Gema Moreno-Bueno, María Gión, José Perez-García, Javier Cortés, Bozena Smolkova, José Palacios
The proposed role of CDH1 (E-cadherin gene) methylation as a mechanism of gene inactivation in invasive lobular carcinoma (ILC) remains inconclusive. For many years, CDH1 promoter hypermethylation has been regarded as a mechanism for gene inactivation in ILC. However, this assumption has primarily relied on non-quantitative assays, which have reported CDH1 methylation frequencies ranging from 26 to 93% at CpG sites within the island region. Few studies employing quantitative methods and covering CpG island shores, regions of relatively low CpG density situated proximal to conventional promoter CpGs, have been conducted, revealing lower percentages of methylation ranging from 0 to 51%...
May 7, 2024: Virchows Archiv: An International Journal of Pathology