keyword
MENU ▼
Read by QxMD icon Read
search

squamous carcinoma

keyword
https://www.readbyqxmd.com/read/29792310/bet-inhibition-overcomes-receptor-tyrosine-kinase-mediated-cetuximab-resistance-in-hnscc
#1
Brandon Leonard, Toni M Brand, Rachel A O'Keefe, Eliot Lee, Yan Zang, Jacquelyn D Kemmer, Hua Li, Jennifer R Grandis, Neil E Bhola
Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resistance in HNSCC is driven by alternative receptor tyrosine kinases (RTK) including HER3, MET, and AXL. In an effort to overcome cetuximab resistance and circumvent toxicities associated with the administration of multiple RTK inhibitors, we sought to identify a common molecular target that regulates expression of multiple RTK...
May 23, 2018: Cancer Research
https://www.readbyqxmd.com/read/29791975/cd44-and-aldh1-immunoexpression-as-prognostic-indicators-of-invasion-and-metastasis-in-oral-squamous-cell-carcinoma
#2
Rafael Carneiro Ortiz, Nathália Martins Lopes, Nadia Ghinelli Amôr, José Burgos Ponce, Cláudia Kliemann Schmerling, Vanessa Soares Lara, Raquel Ajub Moyses, Camila Oliveira Rodini
BACKGROUND: Tumour metastasis has been associated with cancer stem cells, a small population with stem-like cells properties, higher rate of migration and metastatic potential compared to cells from the tumour bulk. Our aim was to evaluate the immunoexpression of the putative cancer stem cell biomarkers ALDH1 and CD44 in primary tumour and corresponding metastatic lymph nodes. METHODS: Tumour tissue specimens (n=50) and corresponding metastatic lymph nodes (n=25) were surgically obtained from 50 patients with oral squamous cell carcinoma and submitted to immunohistochemistry...
May 23, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29791034/high-expression-of-cd10-in-anaplastic-thyroid-carcinomas
#3
Tadao Nakazawa, Tetsuo Kondo, Huy Gia Vunong, Toru Odate, Masataka Kawai, Ippei Tahara, Kazunari Kasai, Tomohiro Inoue, Naoki Oishi, Kunio Mochizuki, Koichi Ito, Ryohei Katoh
AIMS: CD10 is an endopeptidase that degrades variable bioactive peptides in extra-cellular matrix. In addition to the enzymatic degradation, it affects multiple intra-cellular signal transduction pathways. CD10 expression has been extensively studied in human epithelial cancers of numerous organs and sites. However, its presence is not fully determined in thyroid carcinomas, especially in anaplastic thyroid carcinoma (ATC). METHODS AND RESULTS: We examined CD10 by immunohistochemistry (IHC) in 152 thyroid lesions: 9 adenomatous goiters (AGs) and 143 tumors including 47 anaplastic carcinomas...
May 23, 2018: Histopathology
https://www.readbyqxmd.com/read/29790687/expression-profiles-of-selected-genes-in-tumors-and-matched-surgical-margins-in-oral-cavity-cancer-do-we-have-to-pay-attention-to-the-molecular-analysis-of-the-surgical-margins
#4
Joanna K Strzelczyk, Łukasz Krakowczyk, Karolina Gołąbek, Aleksander J Owczarek
BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) are associated with an interplay between genetics and the environment; they account for 3% of all diagnosed malignant tumors in men and 2% of those in women. OBJECTIVES: The aim of the study was to analyze the significance of TIMP3, SFRP1, SFRP2, CDH1, RASSF1, RORA, and DAPK1 gene expression in head and neck squamous cell carcinoma tumors, and in matching surgical margin samples. We also analyzed the association between clinical parameters and the expression of the selected genes...
April 24, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790668/the-effects-of-aberrant-expression-of-lncrna-dgcr5-mir-873-5p-tusc3-in-lung-cancer-cell-progression
#5
Judong Luo, Hong Zhu, Hua Jiang, Yayun Cui, Mengjie Wang, Xinye Ni, Changsheng Ma
Lung cancer is the most common cause of cancer-related mortality worldwide, and nonsmall cell lung cancer (NSCLC) accounts for 80% of all pulmonary carcinomas. Recently, long noncoding RNAs (lncRNAs) have been paid attention for exploring treatment of various diseases. Upregulation of DiGeorge syndrome critical region gene 5 (DGCR5) predicts better lung squamous cell carcinoma prognosis; therefore, we explore the role of DGCR5 in lung cancer in our present study. Consecutive patients with LC were treated in our hospital between January 2015 and January 2016...
May 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29790310/anticancer-activity-of-chlorhexidine-and-cranberry-extract-an-in-vitro-study
#6
Mahesh R Khairnar, Umesh Wadgave, Harish Jadhav, Rahul Naik
Introduction: Oral cancer is considered to be a global pandemic. The study was conducted to assess the anti-cancer activities of Chlorhexidine (CHX) and Cranberry against oral cancer cell lines. Material and Methods: Anticancer activity of CHX and Cranberry extract (CE) was assessed against AW13516 (poorly to moderately differentiated squamous cell carcinoma of tongue) and KB (Nasopharyngeal carcinoma) using Sulforhodamine B (SRB) assay at the Advanced Centre for Treatment Research and Education in Cancer (ACTREC) Mumbai, India...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29790309/assessment-of-hospital-based-prevalence-of-oral-cancer-among-population-of-kanpur-uttar-pradesh
#7
Amrita Raj, Gayathri Ramesh, Sunita Pathak
Background: Oral cancer incidence depends on both qualitative and quantitative factors wherein the incidence of oral cancer in patients with smoking and tobacco chewing habit is 8.4 times higher than that of patients with no habit. Aim: To understand about the prevalence of oral cancer in population of Kanpur reported to the hospital and analyse the association with age, gender and tobacco habit. Material and Method: All 320 cases of Squamous cell carcinoma diagnosed histopathologically, since January 2007 to December 2016, were retrieved from the archives and a retrospective study was conducted along with association with the variables such as age, gender, site, habit and histopathological type...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29790306/the-role-of-novel-prognostic-markers-prox1-and-foxc2-in-carcinogenesis-of-oral-squamous-cell-carcinoma
#8
Neha S Agnihotri, Madhusudan Astekar
Oral squamous cell carcinoma is the most common malignant tumor of the head and neck regions and accounts for more than 90% of cancers in the oral cavity. The angiogenesis, lymphangiogenesis and epithelial mesenchymal transition are known to be pivotal for tumor progression and metastasis. In the last decade, much data has been generated concerning the molecular mechanisms of angiogenesis, lymphangiogenesis and its significance in pathological conditions. The main angiogenic and lymphangiogenic factors have been identified as vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor 2 (VEGFR-2), forkhead box (FOX) C2 while vascular endothelial growth factor C/D (VEGF-C/D), vascular endothelial growth factor receptor 3 (VEGFR-3), Prospero homeobox 1 (PROX1), LYVE-1, podoplanin, Tie/Angioprotein (Ang) 2 and EphrinB2 respectively...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29790264/immune-responses-against-tumor-associated-antigen-derived-cytotoxic-t-lymphocyte-epitopes-in-cholangiocarcinoma-patients
#9
Akihiko Kida, Eishiro Mizukoshi, Toshikatsu Tamai, Takeshi Terashima, Masaaki Kitahara, Kuniaki Arai, Tatsuya Yamashita, Kazumi Fushimi, Masao Honda, Shuichi Kaneko
BACKGROUND & AIMS: Immunotherapy is a promising treatment option for cholangiocarcinoma. We compared cytotoxic T lymphocyte (CTL) responses against several tumor-associated antigen (TAA)-derived epitopes in cholangiocarcinoma patients to identify candidate epitopes for immunotherapy. METHODS: Twenty-six TAAs were selected, and the expression of TAAs in 6 cholangiocarcinoma cell lines and 9 specimens were measured using real-time polymerase chain reaction (PCR)...
May 23, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29790147/sensitivity-and-specificity-of-ex-vivo-dermatoscopy-a-case-series
#10
Danijela Dobrosavljevic, Dimitrije Brasanac, Sofija Glumac, Sanja Radojevic, Lidija Matija, Dejana Stanisavljevic
BACKGROUND: Sensitivity and specificity of ex vivo dermatoscopy (EVD) for malignancy detection of skin tumors is unknown. We sought to assess whether the use of EVD could be a useful adjunct to histopathological diagnosis of pigmented skin tumors, including cases where complete clinical information is inadequate or missing. MATERIALS AND METHODS: EVD was performed on 195 excised, formalin-fixed pigmented skin tumors. RESULTS: Of 183 eligible lesions, 104 (56...
May 23, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29790094/isolation-of-cancer-stem-cells-from-squamous-cell-carcinoma
#11
Silvia Fontenete, Mirna Perez-Moreno
Different cancer stem cell (CSC) populations can be found in many types of cancer, including squamous cell carcinoma (SSC). Diverse reports showed that CSC play a crucial role in the relapse of different types of cancer. CSC sustains tumor growth due to their capacity to self-renew and their potential to initiate secondary tumors with metastatic cancer features. Therefore, the development of methods for the isolation of CSC is a key step to explore the mechanisms underlying CSC maintenance. In this chapter, we provide a method for isolating CSC from cutaneous SSC using immunofluorescence labeling to allow the specific purification of CSC by fluorescence-activated cell sorting (FACS)...
May 23, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29789765/successful-salvage-treatment-of-refractory-recurrence-of-maxillary-sinus-carcinoma-using-image-guided-high-dose-rate-interstitial-brachytherapy
#12
Yin Zhang, Ning Wu, Zhipeng Zhao, Qianqian Chen, Guanghui Cheng
This case report illustrates a treatment effect of image-guided high-dose-rate (HDR) interstitial brachytherapy for refractory recurrence of maxillary sinus carcinoma. A 61-year-old male was previously admitted to another hospital and received surgery because of left maxillary sinus squamous cell carcinoma (SCC) 6 years ago. Tumor regrowth was noted 2 years after the initial radical surgery. The patient accepted local excision again for the recurrence, followed by external beam radiotherapy. Despite salvage treatment with surgery and external irradiation, the lesion expanded as 4...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789760/high-dose-rate-brachytherapy-in-treatment-of-non-melanoma-skin-cancer-of-head-and-neck-region-preliminary-results-of-a-prospective-single-institution-study
#13
Bita Kalaghchi, Ebrahim Esmati, Reza Ghalehtaki, Marzieh Gomar, Ramin Jaberi, Soraya Gholami, Somayyeh Babaloui, Mansoureh Nabavi, Sarvazad Sotoudeh, Nezhat Khanjani, Ali Kazemian, Farnaz Amouzegar-Hashemi, Mahdi Aghili, Marzieh Lashkari
Purpose: Skin cancers are the most common human malignancy with increasing incidence. Currently, surgery is standard of care treatment for non-melanoma skin cancers. However, brachytherapy is a growing modality in the management of skin cancers. Therefore, we aimed to assess the outcome of patients with non-melanoma skin cancers treated by high-dose-rate (HDR) brachytherapy with surface mold technique. Material and methods: In this prospective study, we recruited patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin who were candidates for definitive or adjuvant brachytherapy during 2013-2014...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789538/salvanic-acid-b-inhibits-glycolysis-in-oral-squamous-cell-carcinoma-via-targeting-pi3k-akt-hif-1%C3%AE-signaling-pathway
#14
Jie Wei, Jun Wu, Wen Xu, Hong Nie, Ruiqing Zhou, Rui Wang, Yang Liu, Guoyao Tang, Jianyong Wu
Our previous study demonstrated a progressive glycolytic perturbation during the course of DMBA-induced hamster oral carcinogenesis, which was attenuated by salvianolic acid B (Sal-B) treatment along with decreased incidences of oral squamous cell carcinoma (OSCC) formation. It was proposed that metabolic modulation should be an additional mode of action attributable to Sal-B's anti-carcinogenic activity. However, the molecular mechanisms underlying Sal-B-induced metabolic modulation function remained elusive...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29789211/distress-thermometer-for-preoperative-screening-of-patients-with-oral-squamous-cell-carcinoma
#15
Juliana-Theresa Schell, Andrea Petermann-Meyer, Anita Kloss-Brandstätter, Alexander K Bartella, Mohammad Kamal, Frank Hölzle, Bernd Lethaus, Jan Teichmann
In this study, we evaluate the association between distress, various demographic and medical variables, and the prevalence of psychosocial distress in preoperative patients with oral squamous cell carcinoma. A total of 100 consecutive patients were recruited into the study and asked to complete the Distress Thermometer (DT) form with the Problem List questionnaire prior to surgical intervention; the average distress score was 5.7 ± 2.7. The distress score was neither correlated with age (r = -0.025; p = 0...
May 9, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29788963/cervical-small-cell-carcinoma-frequently-presented-in-multiple-high-risk-hpv-infection-and-often-associated-with-other-type-of-epithelial-tumors
#16
Peifeng Li, Jing Ma, Xiumin Zhang, Yong Guo, Yixiong Liu, Xia Li, Danhui Zhao, Zhe Wang
BACKGROUND: Small cell carcinoma of the uterine cervix is a rare and highly malignant tumor, and its etiopathogenesis is strongly related to high-risk HPV infections. METHODS: The clinicopathological data of 30 cases of cervical primary small cell carcinoma were retrospectively analyzed. In situ hybridization, polymerase chain reaction and reverse dot-blot hybridization were employed to detect HPV DNA in both small cell carcinoma and other coexisting epithelial tumors...
May 22, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29788830/response-disease-free-interval-and-overall-survival-of-cats-with-nasal-planum-squamous-cell-carcinoma-treated-with-a-fractionated-vs-a-single-dose-protocol-of-strontium-plesiotherapy
#17
Davide Berlato, Sue Murphy, Silja Laberke, Sara Verganti
Objectives The main aim of the study was to establish response, disease-free interval (DFI) and overall survival of cats with nasal planum squamous cell carcinoma (SCC) treated with Sr90 plesiotherapy. A secondary aim was to determine whether a fractionated protocol is more effective than a single-dose protocol in terms of response, DFI and overall survival. The third aim was to evaluate whether we can identify prognostic factors that influence overall survival. Methods This was a retrospective study that included cats with a diagnosis of nasal planum SCC treated with Sr90 plesiotherapy at a single institution...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29788741/foxa1-and-ck7-expression-in-esophageal-squamous-cell-carcinoma-and-its-prognostic-significance
#18
Y Xu, W Wang, L Li, J Liu, X Wu, J Yu, H Wang, W Cui, R Zhang
Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors in human. Some ESCC cells express adenocarcinoma cell markers, such as Cytokeratin 7 (CK7), but the clinical significance of these cells in ESCC is unknown. Immunohistochemical analysis of CK7 and Fork head box protein A1(FOXA1, an upstream regulator of CK7) was performed on 610 ESCC specimens using tissue microarray. In total, positive staining of CK7 was 59/594 (10%). CK7 expression was correlated with ESCC differentiation (P=0...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788173/overexpression-of-golgi-phosphoprotein-2-is-associated-with-poor-prognosis-in-oral-squamous-cell-carcinoma
#19
Hao Li, Lei-Lei Yang, Yao Xiao, Wei-Wei Deng, Lei Chen, Lei Wu, Wen-Feng Zhang, Zhi-Jun Sun
Objectives: The aims of this study were to investigate the relationship between Golgi phosphoprotein 2 (GOLPH2) and oral squamous cell carcinoma (OSCC) and explore the clinical significance of GOLPH2 in OSCC. Methods: Tissue microarrays from human OSCC samples were stained for GOLPH2 expression and clinicopathologic features. Kaplan-Meier analysis was used to compare the survival of patients with high GOLPH2 expression and patients with low GOLPH2 expression. Results: We found GOLPH2 is highly expressed in OSCC tissue, and the GOLPH2 expression in metastatic lymph nodes is higher than in tumor tissue...
May 16, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29788107/n2-lung-cancer-is-not-all-the-same-an-analysis-of-different-prognostic-groups
#20
Pietro Bertoglio, Sara Ricciardi, Greta Alì, Vittorio Aprile, Stylianos Korasidis, Gerardo Palmiero, Gabriella Fontanini, Alfredo Mussi, Marco Lucchi
OBJECTIVES: The International Association for the Study of Lung Cancer (IASLC) recently proposed a change in the staging system for N2, based on the metastatic station number: N2a1 (a single metastatic station with no hilar involvement), N2a2 (a single metastatic station with hilar involvement) and N2b (multiple metastatic stations). The aim of our study was to validate the IASLC proposal in a cohort of patients with pathological N2 disease. METHODS: All patients with pathological T1-T2 N2 non-small-cell lung cancer who were operated on between 2006 and 2010 in our department were enrolled...
May 19, 2018: Interactive Cardiovascular and Thoracic Surgery
keyword
keyword
97834
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"