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https://www.readbyqxmd.com/read/27906734/distance-educators-forgotten-faculty-or-positive-disruptors
#1
Cathy J Thompson
No abstract text is available yet for this article.
January 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/27906127/malaria-parasite-celtos-targets-the-inner-leaflet-of-cell-membranes-for-pore-dependent-disruption
#2
John R Jimah, Nichole D Salinas, Monica Sala-Rabanal, Nathaniel G Jones, L David Sibley, Colin G Nichols, Paul H Schlesinger, Niraj H Tolia
Apicomplexan parasites contain a conserved protein CelTOS that, in malaria parasites, is essential for traversal of cells within the mammalian host and arthropod vector. However, the molecular role of CelTOS is unknown because it lacks sequence similarity to proteins of known function. Here, we determined the crystal structure of CelTOS and discovered CelTOS resembles proteins that bind to and disrupt membranes. In contrast to known membrane disruptors, CelTOS has a distinct architecture, specifically binds phosphatidic acid commonly present within the inner leaflet of plasma membranes, and potently disrupts liposomes composed of phosphatidic acid by forming pores...
December 1, 2016: ELife
https://www.readbyqxmd.com/read/27902454/environmental-chemicals-as-endocrine-disruptors
#3
David O Carpenter, Peter D Sly
No abstract text is available yet for this article.
December 1, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27901017/daily-intake-and-hazard-index-of-parabens-based-upon-24%C3%A2-h-urine-samples-of-the-german-environmental-specimen-bank-from-1995-to-2012
#4
Rebecca K Moos, Petra Apel, Christa Schröter-Kermani, Marike Kolossa-Gehring, Thomas Brüning, Holger M Koch
In recent years, exposure to parabens has become more of a concern because of evidence of ubiquitous exposure in the general population, combined with evidence of their potency as endocrine disruptors. New human metabolism data from oral exposure experiments enable us to back calculate daily paraben intakes from urinary paraben levels. We report daily intakes (DIs) for six parabens based on 660 24 h urine samples from the German Environmental Specimen Bank collected between 1995 and 2012. Median DI values ranged between 1...
November 30, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27890585/cadmium-in%C3%A2-vivo-exposure-alters-stress-response-and-endocrine-related-genes-in-the-freshwater-snail-physa-acuta-new-biomarker-genes-in-a-new-model-organism
#5
Pedro Martínez-Paz, Mónica Morales, Paloma Sánchez-Argüello, Gloria Morcillo, José Luis Martínez-Guitarte
The freshwater snail Physa acuta is a sensitive organism to xenobiotics that is appropriate for toxicity testing. Cadmium (Cd) is a heavy metal with known toxic effects on several organisms, which include endocrine disruption and activation of the cellular stress responses. There is scarce genomic information on P. acuta; hence, in this work, we identify several genes related to the hormonal system, the stress response and the detoxification system to evaluate the effects of Cd. The transcriptional activity of the endocrine-related genes oestrogen receptor (ER), oestrogen-related receptor (ERR), and retinoid X receptor (RXR), the heat shock proteins genes hsp70 and hsp90 and a metallothionein (MT) gene was analysed in P...
November 24, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27884139/brominated-flame-retardants-in-placental-tissues-associations-with-infant-sex-and-thyroid-hormone-endpoints
#6
Christopher Leonetti, Craig M Butt, Kate Hoffman, Stephanie C Hammel, Marie Lynn Miranda, Heather M Stapleton
BACKGROUND: Brominated flame retardants (BFRs) are endocrine disruptors that bioaccumulate in the placenta, but it remains unclear if they disrupt tissue thyroid hormone (TH) metabolism. Our primary goal was to investigate associations between placental BFRs, TH levels, Type 3 deiodinase (DIO3) activity and TH sulfotransferase (SULT) activities. METHODS: Placenta samples collected from 95 women who delivered term (>37 weeks) infants in Durham, NC, USA (enrolled 2010-2011) were analyzed for polybrominated diphenyl ethers (PBDEs), 2,4,6-tribromophenol (2,4,6-TBP), THs (T4, T3 and rT3), and DIO3 and TH SULT activities...
November 25, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27882994/stand-firm-on-hormone-disruptors
#7
COMMENT
Leonardo Trasande
No abstract text is available yet for this article.
November 22, 2016: Nature
https://www.readbyqxmd.com/read/27876630/disruptions-of-the-genes-involved-in-lysine-biosynthesis-iron-acquisition-and-secondary-metabolisms-affect-virulence-and-fitness-in-metarhizium-robertsii
#8
Bruno Giuliano Garisto Donzelli, B Gillian Turgeon, Donna M Gibson, Stuart B Krasnoff
Based on genomic analysis, polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) pathways account for biosynthesis of the majority of the secondary metabolites produced by the entomopathogenic fungus Metarhizium robertsii. To evaluate the contribution of these pathways to M. robertsii fitness and/or virulence, mutants deleted for mrpptA, the Sfp-type 4' phosphopantetheinyl transferase gene required for their activation were generated. ΔmrpptA strains were deficient in PKS and NRPS activity resulting in colonies lacking the typical green pigment that failed to produce the nonribosomal peptides destruxins, serinocylins, and the siderophores ferricrocin and metachelins, as well as the hybrid polyketide-peptides NG-39x that are all produced by the wild type (WT) M...
November 19, 2016: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/27875720/multi-generational-xenoestrogenic-effects-of-perfluoroalkyl-acids-pfaas-mixture-on-oryzias-latipes-using-a-flow-through-exposure-system
#9
Jin Wuk Lee, Jae-Woo Lee, Yu-Jin Shin, Ji-Eun Kim, Tae-Kwon Ryu, Jisung Ryu, Jaean Lee, Pilje Kim, Kyunghee Choi, Kyunghwa Park
To elucidate the multi-generational estrogenic potential of Perfluoroalkyl acids (PFAAs) mixture, vitellogenin (VTG) expression, growth indices, histological alteration, fecundity, hatching rate, larval survival rate, and sex ratio of Japanese medaka (Oryzias latipes) were investigated by exposing the fish to a mixture of perfluorooctane sulfonate (PFOS), perfluroroctanoic acid (PFOA), perfluorobutane sulfonate (PFBS), and perfluorononanoic acid (PFNA) for three generations (238 days). Mixture composition is in the ratio of 1:1:1:1...
November 19, 2016: Chemosphere
https://www.readbyqxmd.com/read/27870105/evaluating-the-effects-of-discriminability-on-behavioral-persistence-during-and-following-time-based-reinforcement
#10
Valdeep Saini, Wayne W Fisher
With four children with autism we evaluated a refinement to time-based reinforcement designed to reduce response persistence when we simultaneously introduced time-based reinforcement and extinction. We further evaluated whether this refinement mitigated response recurrence when all reinforcer deliveries ceased during an extinction-only disruptor phase. The refinement involved increasing the saliency of the contingency change from contingent reinforcement (during baseline) to time-based reinforcement by delivering different colored reinforcers during time-based reinforcement...
November 2016: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/27867807/screening-for-potential-endocrine-disruptors-in-fish-evidence-from-structural-alerts-and-in-vitro-and-in-vivo-toxicological-assays
#11
Monika Nendza, Andrea Wenzel, Martin Müller, Geertje Lewin, Nelly Simetska, Frauke Stock, Jürgen Arning
BACKGROUND: The European chemicals' legislation REACH aims to protect man and the environment from substances of very high concern (SVHC). Chemicals like endocrine disruptors (EDs) may be subject to authorization. Identification of (potential) EDs with regard to the environment is limited because specific experimental assessments are not standard requirements under REACH. Evidence is based on a combination of in vitro and in vivo experiments (if available), expert judgement, and structural analogy with known EDs...
2016: Environmental Sciences Europe
https://www.readbyqxmd.com/read/27862981/standardization-of-sample-homogenization-for-mosquito-identification-using-an-innovative-proteomic-tool-based-on-protein-profiling
#12
Amira Nebbak, Alexandra C Willcox, Idir Bitam, Didier Raoult, Philippe Parola, Lionel Almeras
The rapid spread of vector-borne diseases demands the development of an innovative strategy for arthropod monitoring. The emergence of MALDI-TOF MS as a rapid, low-cost and accurate tool for arthropod identification is revolutionizing medical entomology. However, as MS spectra from an arthropod can vary according to the body part selected, the sample homogenization method used and the mode and duration of sample storage, standardization of protocols is indispensable prior to the creation and sharing of an MS reference spectra database...
November 12, 2016: Proteomics
https://www.readbyqxmd.com/read/27856373/a-systematic-study-of-the-release-of-bisphenol-a-by-orthodontic-materials-and-its-biological-effects
#13
Abdelali Halimi, Hicham Benyahia, Loubna Bahije, Hanane Adli, Mohamed-Faouzi Azeroual, Fatima Zaoui
INTRODUCTION: Bisphenol A (BPA) is a synthetic chemical substance used as a starting ingredient in the manufacturing process of a number or orthodontic materials. It is a well-known endocrine disruptor with low estrogenic properties. The aim of this investigation is to present a systematic review regarding the issue of bisphenol A release by orthodontic materials and its impact in orthodontics. MATERIALS AND METHODS: A systematic analysis was performed by electronic search (between 1936 and 2015) on several data bases...
November 14, 2016: International Orthodontics
https://www.readbyqxmd.com/read/27856274/improved-assessment-of-sensorimotor-gating-in-animal-models-relevant-to-asd-a-data-modelling-approach-to-quantify-prepulse-inhibition-of-the-acoustic-startle-reflex
#14
Stéphanie Degroote, Darel Hunting, Larissa Takser
BACKGROUND: The PrePulse Inhibition (PPI) of the acoustic startle reflex is a neurobehavioral test frequently used in neurodevelopmental studies. Most PPI studies have used rodent models of schizophrenia; however, the currently used data analysis method does not take into account the variability present in autistic preclinical models. NEW METHOD: We propose a new data modelling approach for PPI data obtained from animals exposed to valproic acid or endocrine disruptors, using mixed modeling; and a new calculation of inhibition of the acoustic startle, which takes into account the habituation phenomenon...
November 14, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27855729/symptoms-of-restless-legs-syndrome-in-biological-caregivers-of-children-with-autism-spectrum-disorders
#15
Maureen Russell, Carol Baldwin, Darya McClain, Nicole Matthews, Christopher Smith, Stuart F Quan
STUDY OBJECTIVES: In this study, we investigated the prevalence of symptoms of restless legs syndrome (RLS) in biological caregivers of children with a diagnosis of autism spectrum disorder (ASD).The relationship of RLS symptoms to caregiver health-related quality of life (HRQoL) was also examined. Finally, we compared the sleep quality and daytime behaviors of children with ASD in caregivers with and without symptoms of RLS. METHODS: Biological caregivers (N = 50) of children ages 6 to 11 y with a diagnosis of ASD completed a Sleep Habits Questionnaire (SHQ) that included RLS as determined by four questions...
October 28, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27853917/benzene-and-2-ethyl-phthalate-induce-proliferation-in-normal-rat-pituitary-cells
#16
Laura Tapella, Antonella Sesta, Maria Francesca Cassarino, Valentina Zunino, Maria Graziella Catalano, Francesca Pecori Giraldi
PURPOSE: Endocrine disruptors are known to modulate a variety of endocrine functions and increase the risk for neoplasia. Epidemiological data reported increased prevalence of pituitary tumors in high industrial areas while genotyping studies showed that mutations in the aryl hydrocarbon receptor (AhR) interacting protein (AIP)-chaperone to the dioxin ligand AhR-gene are linked to predisposition to pituitary tumor development. Aim of the present study was to establish whether endocrine pollutants can induce cell proliferation in normal rat pituitary cells...
November 16, 2016: Pituitary
https://www.readbyqxmd.com/read/27852784/activity-induces-fmr1-sensitive-synaptic-capture-of-anterograde-circulating-neuropeptide-vesicles
#17
Samantha L Cavolo, Dinara Bulgari, David L Deitcher, Edwin S Levitan
: Synaptic neuropeptide and neurotrophin stores are maintained by constitutive bidirectional capture of dense-core vesicles (DCVs) as they circulate in and out of the nerve terminal. Activity increases DCV capture to rapidly replenish synaptic neuropeptide stores following release. However, it is not known whether this is due to enhanced bidirectional capture. Here experiments at the Drosophila neuromuscular junction, where DCVs contain neuropeptides and a bone morphogenic protein, show that activity-dependent replenishment of synaptic neuropeptides following release is evident after inhibiting the retrograde transport with the dynactin disruptor mycalolide B or photobleaching DCVs entering a synaptic bouton by retrograde transport...
November 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27852690/maternal-use-of-mild-analgesics-during-pregnancy-associated-with-reduced-anogenital-distance-in-sons-a-cohort-study-of-1027-mother-child-pairs
#18
Dorte Vesterholm Lind, Katharina M Main, Henriette Boye Kyhl, David Møbjerg Kristensen, Jorma Toppari, Helle Raun Andersen, Marianne Skovsager Andersen, Niels E Skakkebæk, Tina Kold Jensen
STUDY QUESTION: Is maternal use of mild analgesics in pregnancy associated with anogenital distance (AGD)-the distance from the anus to the genitals-in the offspring? SUMMARY ANSWER: Maternal use of mild analgesics [especially simultaneous use of paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs)] during pregnancy was associated with a shorter AGD in boys whereas no effect was found in girls. WHAT IS KNOWN ALREADY: Mild analgesics including paracetamol (acetaminophen) and NSAIDs (e...
November 16, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27845755/effects-of-di-2-ethylhexyl-phthalate-on-the-hypothalamus-uterus-in-pubertal-female-rats
#19
Te Liu, Yiyang Jia, Liting Zhou, Qi Wang, Di Sun, Jin Xu, Juan Wu, Huaiji Chen, Feng Xu, Lin Ye
The pollution of endocrine disruptors and its impact on human reproductive system have attracted much attention. Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely used in food packages, containers, medical supplies and children's toys. It can cause diseases such as infertility, sexual precocity and uterine bleeding and thus arouse concerns from the society and scholars. The effect of DEHP on pubertal female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on the hypothalamus-uterus in pubertal female rats, reveal the reproductive toxicity of DEHP on pubertal female rats and its mechanism, and provide scientific evidence for the evaluation of toxicity and toxic mechanism of DEHP on reproductive system...
November 12, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27837466/thyroid-disruption-by-perfluorooctane-sulfonate-pfos-and-perfluorooctanoate-pfoa
#20
REVIEW
F Coperchini, O Awwad, M Rotondi, F Santini, M Imbriani, L Chiovato
BACKGROUND: Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are two fluorinated compounds widely used in industry because of their useful chemical characteristics. They were identified as endocrine disruptors due to their ability to interfere with thyroid function. The resistance of PFOA and PFOS to environmental degradation, their bio-accumulation in food chains, and their long half-life raised concern in the scientific community, and several studies were performed with the aim to establish the real dangerousness of these compounds for the human health...
November 11, 2016: Journal of Endocrinological Investigation
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