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https://www.readbyqxmd.com/read/28081510/gestational-and-lactational-exposure-to-di-isobutyl-phthalate-via-diet-in-maternal-mice-decreases-testosterone-levels-in-male-offspring
#1
Xiaoyang Wang, Nan Sheng, Ruina Cui, Hongxia Zhang, Jianshe Wang, Jiayin Dai
Phthalates are a large family of ubiquitous environmental chemicals suspected of being endocrine disruptors, with exposure to these chemicals during prenatal and postnatal development possibly resulting in reproductive disorders. Di-isobutyl phthalate (DiBP) is widely used in consumer and industrial products, and although its exposure in the general population has increased in recent years, the mechanisms behind DiBP-induced reproductive disorders in male offspring remain unclear. Here, pregnant mice were exposed to 0 or 450 mg/kg bw/day DiBP via diet from gestation day (GD) 0 to GD21...
January 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28065941/di2-ethylhexyl-phthalate-disrupts-thyroid-hormone-homeostasis-through-activating-the-ras-akt-trhr-pathway-and-inducing-hepatic-enzymes
#2
Hanfeng Ye, Mei Ha, Min Yang, Ping Yue, Zhengyuan Xie, Changjiang Liu
Di(2-ethylhexyl) phthalate (DEHP), as a widespread environmental pollutant and an endocrine disruptor, can disturb the homeostasis of thyroid hormones (THs). In order to elucidate roles of the MAPK and PI3K/Akt pathways and hepatic enzymes in thyroid-disrupting effects of DEHP, Sprague-Dawley rats were dosed with DEHP by gavage for 30 consecutive days; Nthy-ori 3-1 cells were treated with DEHP with NAC, k-Ras siRNA or inhibitors (U0126 and wortmannin). Results showed that DEHP led to histopathologic changes in rat thyroid and liver, such as the decrease in thyroid follicular cavity diameter, hepatocyte edema...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28063299/miniaturization-of-a-transthyretin-binding-assay-using-a-fluorescent-probe-for-high-throughput-screening-of-thyroid-hormone-disruption-in-environmental-samples
#3
Xiyu Ouyang, Jean Froment, Pim E G Leonards, Guttorm Christensen, Knut-Erik Tollefsen, Jacob de Boer, Kevin V Thomas, Marja H Lamoree
Thyroid hormone (TH) disrupting compounds are potentially important environmental contaminants due to their possible adverse neurological and developmental effects on both humans and wildlife. Currently, the most successful bio-analytical method to detect and evaluate TH disruptors, which target the plasma transport of TH in environmental samples, is the radio-ligand thyroxine-transthyretin (T4-TTR) binding assay. Yet, costly materials and tedious handling procedures prevent the use of this assay in high throughput analysis that is nowadays urgently demanded in environmental quality assessment...
December 23, 2016: Chemosphere
https://www.readbyqxmd.com/read/28061508/structure-based-understanding-of-binding-affinity-and-mode-of-estrogen-receptor-%C3%AE-agonists-and-antagonists
#4
Sehan Lee, Mace G Barron
The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor α (ERα) allows the binding of a wide variety of endocrine disruptors. Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydrophobic interactions and specific hydrogen bonds with the ligand. Here we present a framework for quantitative analysis of the steric and electronic features of the human ERα-ligand complex using three dimensional (3D) protein-ligand interaction description combined with 3D-QSAR approach...
2017: PloS One
https://www.readbyqxmd.com/read/28052490/population-relevant-endpoints-in-the-evaluation-of-endocrine-active-substances-eas-for-ecotoxicological-hazard-and-risk-assessment
#5
Mary S Marty, Amy Blankinship, Janice Chambers, Lisa Constantine, Werner Kloas, Anupama Kumar, Laurent Lagadic, James Meador, Daniel Pickford, Tamar Schwarz, Tim Verslycke
For ecotoxicological risk assessment, endocrine disruptors require the establishment of an endocrine mode of action (MoA) with a plausible linkage to a population-relevant adverse effect. Current ecotoxicity test methods mostly incorporate apical endpoints although some also include mechanistic endpoints, subcellular-through-organ-level, which can help establish an endocrine MoA. However, the link between these endpoints and adverse population-level effects is often unclear. The case studies of endocrine-active substances (EAS) (tributyltin, ethinylestradiol, perchlorate, trenbolone, propiconazole, and vinclozolin) evaluated for the SETAC Pellston Workshop™: Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Chemicals were used to evaluate the population relevance of toxicity endpoints in various taxa according to regulatory endocrine disruptor frameworks such as the OECD Conceptual Framework for Testing and Assessment of Endocrine Disruptors...
January 4, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28051323/bisphenol-a-interferes-with-swine-vascular-endothelial-cell-functions
#6
Giuseppina Basini, Simona Bussolati, Stefano Grolli, Roberto Ramoni, Francesca Grasselli
Several studies have demonstrated that the endocrine disruptor bisphenol A (BPA) negatively affects animal and human health. An angiogenic process has been suggested among the events disrupted by this molecule, but the underlying mechanisms have not yet been clarified. The effect of BPA on angiogenesis was investigated by means of a bioassay previously validated in our laboratory. Using immortalized swine aortic endothelial cell line (AOC), the development of new blood vessels through a three-dimensional in vitro angiogenesis assay was evaluated...
October 20, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28043741/exposure-to-benzo-a-pyrene-impairs-decidualization-and-decidual-angiogenesis-in-mice-during-early-pregnancy
#7
Xueyan Li, Cha Shen, Xueqing Liu, Junlin He, Yubin Ding, Rufei Gao, Xinyi Mu, Yanqing Geng, Yingxiong Wang, Xuemei Chen
Benzo[a]pyrene (BaP) is a ubiquitous environmental persistent organic pollutant and a well-known endocrine disruptor. BaP exposure could alter the steroid balance in females. Endometrium decidualization and decidual angiogenesis are critical events for embryo implantation and pregnancy maintenance during early pregnancy and are modulated by steroids. However, the effect of BaP on decidualization is not clear. This study aimed to explore the effects of BaP on decidualization and decidual angiogenesis in pregnant mice...
December 30, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/28042663/all-our-sons-the-developmental-neurobiology-and-neuroendocrinology-of-boys-at-risk
#8
Allan N Schore
Why are boys at risk? To address this question, I use the perspective of regulation theory to offer a model of the deeper psychoneurobiological mechanisms that underlie the vulnerability of the developing male. The central thesis of this work dictates that significant gender differences are seen between male and female social and emotional functions in the earliest stages of development, and that these result from not only differences in sex hormones and social experiences but also in rates of male and female brain maturation, specifically in the early developing right brain...
January 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/28039834/disruption-of-sex-hormone-levels-and-steroidogenic-related-gene-expression-on-mongolia-racerunner-eremias-argus-after-exposure-to-triadimefon-and-its-enantiomers
#9
Jitong Li, Jing Chang, Wei Li, Baoyuan Guo, Jianzhong Li, Huili Wang
Triadimefon (TF) is a widely used chiral fungicide with one chiral centre and two enantiomers (TF1 and TF2). However, little is reported about the ecological toxicity of reptiles on an enantioselective level. TF is a potential endocrine disruptor that may interfere with sex steroid hormones, such as testosterone (T) and 17beta-estradiol (E2). In our study, the lizards Mongolia Racerunner (Eremias argus) were orally exposed to TF and its enantiomers for 21 days. Plasma sex steroid hormones and steroidogenic-related genes, including 17-beta-hydroxysteroid (hsd17β), cytochrome P450 enzymes (cyp19 and cyp17), and steroid hormone receptors (erα and Ar) were evaluated...
December 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/28036072/maternal-exposure-to-domestic-hair-cosmetics-and-occupational-endocrine-disruptors-is-associated-with-a-higher-risk-of-hypospadias-in-the-offspring
#10
Elodie Haraux, Karine Braun, Philippe Buisson, Erwan Stéphan-Blanchard, Camille Devauchelle, Jannick Ricard, Bernard Boudailliez, Pierre Tourneux, Richard Gouron, Karen Chardon
Pregnant women are exposed to various chemical products at home and at work. Some of these products contain endocrine-disrupting chemicals (EDCs) such as cosmetics, pesticides, industrial chemicals, heavy metals, plastics or medications that could alter sexual differentiation and increase the risk of hypospadias. We evaluated maternal occupational and household exposures that could constitute risk factors for hypospadias. From 2011 to 2014, we enrolled 57 full-term newborns with hypospadias and three randomly selected controls per case (162 control newborns), matched for gestational age, from 11 maternity units in Picardy, France...
December 29, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28032145/neurodevelopmental-disorders-and-pesticide-exposure-the-northeastern-italian-experience
#11
EDITORIAL
L Roncati, T Pusiol, F Piscioli, A M Lavezzi
Endocrine disruptors are chemical substances that can interfere with the endocrine system. They include pesticides, metals, additives or contaminants in food, and personal care products. Pesticides are the only substances intentionally released into our environment to kill living things (herbicides, insecticides, fungicides, rodenticides). There is scientific evidence that exposure to pesticides produces a growing number of human pathological conditions; among these, stillbirth is an emerging issue.
December 28, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/28031325/diethylstilbestrol-activates-catsper-and-disturbs-progesterone-actions-in-human-spermatozoa
#12
Qian-Xing Zou, Zhen Peng, Qing Zhao, Hou-Yang Chen, Yi-Min Cheng, Qing Liu, Yuan-Qiao He, Shi-Qi Weng, Hua-Feng Wang, Tao Wang, Li-Ping Zheng, Tao Luo
STUDY QUESTION: Is diethylstilbestrol (DES), a prototypical endocrine-disrupting chemical (EDC), able to induce physiological changes in human spermatozoa and affect progesterone actions? SUMMARY ANSWER: DES promoted Ca(2+) flux into human spermatozoa by activating the cation channel of sperm (CatSper) and suppressed progesterone-induced Ca(2+) signaling, tyrosine phosphorylation and sperm functions. WHAT IS KNOWN ALREADY: DES significantly impairs the male reproductive system both in fetal and postnatal exposure...
December 28, 2016: Human Reproduction
https://www.readbyqxmd.com/read/28031075/prenatal-phthalate-exposure-and-8-isoprostane-among-mexican-american-children-with-high-prevalence-of-obesity
#13
V Tran, G Tindula, K Huen, A Bradman, K Harley, K Kogut, A M Calafat, B Nguyen, K Parra, X Ye, B Eskenazi, N Holland
Oxidative stress has been linked to many obesity-related conditions among children including cardiovascular disease, diabetes mellitus and hypertension. Exposure to environmental chemicals such as phthalates, ubiquitously found in humans, may also generate reactive oxygen species and subsequent oxidative stress. We examined longitudinal changes of 8-isoprostane urinary concentrations, a validated biomarker of oxidative stress, and associations with maternal prenatal urinary concentrations of phthalate metabolites for 258 children at 5, 9 and 14 years of age participating in a birth cohort residing in an agricultural area in California...
December 29, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28025458/adverse-effects-of-maternal-exposure-to-bisphenol-f-on-the-anxiety-and-depression-like-behavior-of-offspring
#14
Naoko Ohtani, Hidetomo Iwano, Koshi Suda, Erika Tsuji, Kentaro Tanemura, Hiroki Inoue, Hiroshi Yokota
Bisphenol A (BPA), a well-known endocrine disruptor, is metabolized and eliminated rapidly from the body in adult animals. However, many authors have reported that perinatal BPA exposure alters development of the brain, reproductive system and behavior in the next generation. Recently, BPA substitutes, especially bisphenol F (BPF), have been used because of concerns about the influence of BPA on children, although the actual effects on the next generation are unknown. In this study, we observed behavioral adverse effects of the offspring of mice exposed to BPA or BPF in fetal period...
December 25, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28018591/characterization-of-heavy-users-of-skin-care-products-among-norwegian-women-from-2003-to-2011
#15
Boel Aniansson, Marit B Veierød, Charlotta Rylander, Eiliv Lund, Torkjel M Sandanger
BACKGROUND: Several ingredients in personal care products (PCPs) have been classified as endocrine disruptors (EDs) and concern has been raised whether use of PCPs can affect human health. We aimed to characterize Norwegian female users of skin care products and compare life style characteristics between heavy users and non-users. METHODS: This cross-sectional study consisted of 114 202 women (age 41-76 years) participating in the Norwegian Women and Cancer study, a large population-based prospective cohort study...
2016: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28012845/role-of-melatonin-in-mitigating-nonylphenol-induced-toxicity-in-frontal-cortex-and-hippocampus-of-rat-brain
#16
Heena Tabassum, Mohammad Ashafaq, Suhel Parvez, Sheikh Raisuddin
Nonylphenol (NP), an environmental endocrine disruptor mimics estrogen and is a potential toxicant both under in vitro and in vivo conditions. In this study, the effect of melatonin on NP- induced neurotoxicity and cognitive alteration was investigated in adult male Wistar rats. Melatonin supplementation has been known to protect cells from neurotoxic injury. The animals were divided into three groups namely, control (vehicle) which received olive oil orally and treated rats received NP (25 mg/kg, per os) thrice a week for 45 days while the third group i...
December 21, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/28012841/endocrine-disruptors-and-the-tumor-microenvironment-a-new-paradigm-in-breast-cancer-biology
#17
Hope Burks, Nicholas Pashos, Elizabeth Martin, John Mclachlan, Bruce Bunnell, Matthew Burow
Breast cancer is one of the most frequently diagnosed malignancies in women and is characterized by predominantly estrogen dependent growth. Endocrine disruptors (EDCs) have estrogenic properties which have been shown to increase breast cancer risk. While the direct effects of EDCs on breast cancer cell biology and tumor progression have been well studied, the roles for EDCs on tumor microenvironment composition, signaling and structure are incompletely defined. Estrogen targeting of tumor stromal cells can drive paracrine signaling to breast cancer cells regulating tumorigenesis and progression...
December 21, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28012672/effects-of-triazole-fungicides-on-androgenic-disruption-and-cyp3a4-enzyme-activity
#18
Xuan Lv, Liumeng Pan, Jiaying Wang, Liping Lu, Weilin Yan, Yanye Zhu, Yiwen Xu, Ming Guo, Shulin Zhuang
Triazole fungicides are widely used as broad-spectrum fungicides, non-steroidal antiestrogens and for various industrial applications. Their residues have been frequently detected in multiple environmental and human matrices. The increasingly reported toxicity incidents have led triazole fungicides as emerging contaminants of environmental and public health concern. However, whether triazole fungicides behave as endocrine disruptors by directly mimicking environmental androgens/antiandrogens or exerting potential androgenic disruption indirectly through the inhibition of cytochrome P450 (CYP450) enzyme activity is yet an unresolved question...
December 21, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/28008399/urinary-phthalate-metabolites-and-biomarkers-of-oxidative-stress-in-a-mexican-american-cohort-variability-in-early-and-late-pregnancy
#19
Nina Holland, Karen Huen, Vy Tran, Kelly Street, Brian Nguyen, Asa Bradman, Brenda Eskenazi
People are exposed to phthalates through their wide use as plasticizers and in personal care products. Many phthalates are endocrine disruptors and have been associated with adverse health outcomes. However, knowledge gaps exist in understanding the molecular mechanisms associated with the effects of exposure in early and late pregnancy. In this study, we examined the relationship of eleven urinary phthalate metabolites with isoprostane, an established marker of oxidative stress, among pregnant Mexican-American women from an agricultural cohort...
March 2016: Toxics
https://www.readbyqxmd.com/read/28007384/determination-and-assessment-of-phthalate-esters-content-in-sediments-from-kaohsiung-harbor-taiwan
#20
Chih-Feng Chen, Chiu-Wen Chen, Yun-Ru Ju, Cheng-Di Dong
Phthalate esters (PAEs) are known organic endocrine disruptors. The distribution of 10 PAEs in sediments of Kaohsiung Harbor of Taiwan was studied using organic solvents extraction and quantified by gas chromatography/mass spectrometry. The average concentration of total PAEs (ΣPAEs) in the sediment was 8713±11,454ng/g dw with di-(2-ethylhexyl) phthalate (DEHP) (3630ng/g-dw) and diisononyl phthalate (DiNP) (3497ng/g dw) being the major species, which constitutes of 41.7% and 40.1% of ΣPAEs. PAEs concentration was relatively high near the river mouths, especially in Love River mouth, and diminished toward the harbor...
December 20, 2016: Marine Pollution Bulletin
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