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https://www.readbyqxmd.com/read/29229539/bisphenol-a-bpa-and-cell-signaling-pathways
#1
REVIEW
Masaharu Murata, Jeong-Hun Kang
Bisphenol A (BPA; 4,4'-isopropylidenediphenol) is an endocrine disruptor that is used as a material for the production of phenol resins, polyacrylates, polyesters, epoxy resins, and polycarbonate plastics. Endocrine-disruptive or toxic effects of BPA on living organisms through a number of cell signaling pathways have been reported. BPA induces carcinogenesis, reproductive toxicity, abnormal inflammatory or immune response, and developmental disorders of brain or nervous system through various cell signaling pathways...
December 8, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29228129/prenatal-exposure-to-di-2-ethylhexyl-phthalate-causes-long-term-transgenerational-effects-on-female-reproduction-in-mice
#2
Emily Brehm, Saniya Rattan, Liying Gao, Jodi A Flaws
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer in many consumer products. Although DEHP is a known endocrine disruptor, little is known about the effects of DEHP exposure on female reproduction. Thus, this study tested the hypothesis that prenatal DEHP exposure affects follicle numbers, estrous cyclicity, and hormone levels in multiple generations of mice. Pregnant CD-1 mice were orally dosed with corn oil (vehicle control) or DEHP (20 and 200 µg/kg/day, and 500 and 750 mg/kg/day) from gestation day 10...
December 7, 2017: Endocrinology
https://www.readbyqxmd.com/read/29228121/low-dose-bisphenol-a-activates-the-erk-signaling-pathway-and-attenuates-steroidogenic-gene-expression-in-human-placental-cells
#3
Po-Wei Chu, Zhi-Jie Yang, Huei-Shing Huang, Ai-An Chang, Yu-Chen Cheng, Gwo-Jang Wu, Hsin-Chieh Lan
Bisphenol A (BPA) is an industrial material used for many plastic products and is considered an endocrine disruptor. BPA can be released into the environment and can spread through the food chain. It is well known that BPA exposure leads to lesions, especially in the reproductive system. According to previous studies, BPA reduces newborn numbers in pregnant mice and affects placentation. The placenta is a special endocrine organ during pregnancy. It secretes important hormones, such as progesterone and estrogen, to maintain gestation...
December 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29227648/quinazolinone-based-anticancer-agents-synthesis-anti-proliferative-sar-anti-tubulin-activity-and-tubulin-co-crystal-structure
#4
Wolfgang Dohle, Fabrice L Jourdan, Gregory Menchon, Andrea E Prota, Paul A Foster, Pascoe Mannion, Ernest Hamel, Mark P Thomas, Philip G Kasprzyk, Eric Ferrandis, Michel O Steinmetz, Mathew P Leese, Barry V L Potter
Quinazolinone-based anti-cancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series, incorporating the aryl sulfamate motif of steroid sulfatase (STS) inhibitors. The steroidal AB-ring system was mimicked, favoring conformations with an N-2 substituent occupying D-ring space. Evaluation against breast and prostate tumor cell lines identified 7b with DU-145 anti-proliferative activity (GI50 300 nM). A preliminary structure-activity relationship afforded compounds (e...
December 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29222635/cardiovascular-response-of-rat-aorta-to-di-2-ethylhexyl-phthalate-dehp-exposure
#5
Melissa Mariana, Joana Feiteiro, Elisa Cairrao
Phthalates are one of the main constituents of plastic, reaching up to 40% of the total plastic weight, and their main function is to impart flexibility/elasticity to polymers that would otherwise be rigid. Phthalates are known as endocrine disruptors, since they can interfere with hormone homeostasis. Regarding the cardiovascular system, it was already shown the effects of di-(2-ethylhexyl) phthalate (DEHP) exposure with significant changes in several calcium-handling proteins and an increase in the blood pressure of mice offspring, suggesting that DEHP leads to vasocontraction...
December 8, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29220483/prenatal-exposure-to-bisphenol-a-disrupts-naturally-occurring-bimodal-dna-methylation-at-proximal-promoter-of-fggy-an-obesity-relevant-gene-encoding-a-carbohydrate-kinase-in-gonadal-white-adipose-tissues-of-cd-1-mice
#6
Julia A Taylor, Keiko Shioda, Shino Mitsunaga, Shiomi Yawata, Brittany M Angle, Susan C Nagel, Frederick S Vom Saal, Toshi Shioda
Exposure of mammalian fetuses to endocrine disruptors can increase the risk of adult-onset diseases. For example, we previously showed that exposure of mouse fetuses to bisphenol A (BPA) caused adult-onset obesity. To obtain insights into roles of epigenetic changes in the delayed toxic effects of endocrine disruption, we determined effects of fetal mouse exposure to BPA on genome-wide DNA methylation and mRNA expression in gonadal white adipose tissues by deep sequencing (MBD-seq and RNA-seq), bisulfite pyrosequencing, and real-time qPCR...
December 6, 2017: Endocrinology
https://www.readbyqxmd.com/read/29218402/linking-inter-individual-variability-to-endocrine-disruptors-insights-for-epigenetic-inheritance
#7
Sarah E Latchney, Ashley M Fields, Martha Susiarjo
Endocrine disrupting chemicals (EDCs) can induce a myriad of adverse health effects. An area of active investigation is the multi- and transgenerational inheritance of EDC-induced adverse health effects referring to the transmission of phenotypes across multiple generations via the germline. The inheritance of EDC-induced adverse health effects across multiple generations can occur independent of genetics, spurring much research into the transmission of underlying epigenetic mechanisms. Epigenetic mechanisms play important roles in the development of an organism and are responsive to environmental exposures...
December 7, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29216406/high-throughput-h295r-steroidogenesis-assay-utility-as-an-alternative-and-a-statistical-approach-to-characterize-effects-on-steroidogenesis
#8
Derik E Haggard, Agnes L Karmaus, Matthew T Martin, Richard S Judson, R Woodrow Setzer, Katie Paul Friedman
The U.S. Environmental Protection Agency Endocrine Disruptor Screening Program and the Organization for Economic Co-operation and Development (OECD) have used the human adrenocarcinoma (H295R) cell-based assay to predict chemical perturbation of androgen and estrogen production. Recently, a high-throughput H295R (HT-H295R) assay was developed as part of the ToxCast program that includes measurement of 11 hormones, including progestagens, corticosteroids, androgens, and estrogens. To date, 2012 chemicals have been screened at one concentration; of these, 656 chemicals have been screened in concentration-response...
December 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29215945/the-adverse-effects-of-chronic-low-dose-exposure-to-nonylphenol-on-type-2-diabetes-mellitus-in-high-sucrose-high-fat-diet-treated-rats
#9
Jie Yu, Jin Yang, Ya Luo, Yang Mengxue, Wenmei Li, Yu Yang, Liting He, Jie Xu
OBJECTIVES: Although it has been shown that exposure to environmental endocrine disruptors (EDCs) has been implicated as a potential risk factor for metabolic disease, information on adverse effect of chronic low-dose exposure to nonylphenol (NP), on the development and progress of type 2 diabetes mellitus (T2DM) is scarce. NP, as an EDC, is a ubiquitous degradation product of nonylphenol polyethoxylate (NPE) that is primarily used in cleaning and industrial processes. METHOD: Eighty Sprague-Dawley rats were assigned into 8 groups (n = 10 per group): rats fed a normal-diet (ND) as the control (C-ND); rats fed a normal diet and were gavaged with NP at a dose level of 0...
December 7, 2017: Islets
https://www.readbyqxmd.com/read/29212512/correction-to-parma-consensus-statement-on-metabolic-disruptors
#10
Jerrold J Heindel, Frederick S Vom Saal, Bruce Blumberg, Patrizia Bovolin, Gemma Calamandrei, Graziano Ceresini, Barbara A Cohn, Elena Fabbri, Laura Gioiosa, Christopher Kassotis, Juliette Legler, Michele La Merrill, Laura Rizzi, Ronit Machtinger, Alberto Mantovani, Michelle A Mendez, Luisa Montanini, Laura Molteni, Susan C Nagel, Stefano Parmigiani, Giancarlo Panzica, Silvia Paterlini, Valentina Pomatto, Jérôme Ruzzin, Giorgio Sartor, Thaddeus T Schug, Maria E Street, Alexander Suvorov, Riccardo Volpi, R Thomas Zoeller, Paola Palanza
After publication of the article [1], it has been brought to our attention that the thirteenth author of this article has had their name spelt incorrectly. In the original article the spelling "Laura Rizzir" was used. In fact the correct spelling should be "Laura Rizzi".
December 6, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29197250/in-utero-single-low-dose-exposure-of-cadmium-induces-rat-fetal-leydig-cell-dysfunction
#11
Xiaojun Li, Jianpeng Liu, Siwen Wu, Wenwen Zheng, Huitao Li, Suhao Bao, Yong Chen, Xiaoling Guo, Lei Zhang, Ren-Shan Ge
Cadmium chloride (Cd) is a potent endocrine disruptor and may cause the malformation in the male reproductive tract. However, the effects of a single in utero exposure to low doses of Cd on fetal Leydig cell development are still unknown. The objective of this study is to investigate the effects of a single in utero exposure to low doses of Cd on rat fetal Leydig cell development. Adult 64-day-old Sprague-Dawley dams received a single intraperitoneal injection of 0, 0.25, 0.5, and 1.0 mg/kg Cd on gestational day 12...
November 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29197012/co-culture-of-h295r-adrenocortical-carcinoma-and-bewo-choriocarcinoma-cells-to-study-feto-placental-interactions-focus-on-estrogen-biosynthesis
#12
Andrée-Anne Hudon Thibeault, J Thomas Sanderson, Cathy Vaillancourt
Estrogens are produced in large amounts during pregnancy, as a result of a tightly regulated cooperation between the maternal and fetal adrenal cortex, which produce androgen precursors, and the placental villous trophoblast, which transforms these precursors into estrogens. These estrogens play an important role in proper placental function, in adaptation of the mother to pregnancy, as well as in adequate fetal development. Disruption of estrogen production is associated with poor pregnancy outcomes and fetal malformation or altered fetal programming...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29194942/rnai-technology-in-crop-protection-against-arthropod-pests-pathogens-and-nematodes
#13
REVIEW
Moises Zotti, Ericmar Avila Dos Santos, Deise Cagliari, Olivier Christiaens, Clauvis Nji Tizi Taning, Guy Smagghe
Scientists have made significant progress to understand and unravel several aspects of dsRNA-mediated gene silencing during the last two decades. Now that the RNAi mechanism is well understood, it is time to point out some directions on how to transfer the acquired knowledge into useful applications for agriculture and crop protection. Some RNAi-based products are already available for farmers and more are expected to reach the market soon. The tailor-made dsRNA as an active ingredient for biopesticide formulations is considered a raw material that can be directed to diverse purposes, from pest control and bee protection against viruses to pesticide resistance management...
November 30, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29194390/thyroid-disrupting-chemicals
#14
REVIEW
Valeria Calsolaro, Giuseppe Pasqualetti, Filippo Niccolai, Nadia Caraccio, Fabio Monzani
Endocrine disruptor compounds are exogenous agents able to interfere with a gland function, exerting their action across different functional passages, from the synthesis to the metabolism and binding to receptors of the hormone produced. Several issues, such as different levels and time of exposure and different action across different ages as well as gender, make the study of endocrine disruptors still a challenge. The thyroid is very sensitive to the action of disruptors, and considering the importance of a correct thyroid function for physical and cognitive functioning, addressing this topic should be considered a priority...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29191310/dietary-exposure-to-di-isobutyl-phthalate-increases-urinary-5-methyl-2-deoxycytidine-level-and-affects-reproductive-function-in-adult-male-mice
#15
Yitao Pan, Xiaoyang Wang, Leo W Y Yeung, Nan Sheng, Qianqian Cui, Ruina Cui, Hongxia Zhang, Jiayin Dai
Phthalates are a large family of ubiquitous environmental pollutants suspected of being endocrine disruptors. Epidemiological studies have associated phthalate metabolites with decreased reproductive parameters and linked phthalate exposure with the level of urinary 5-methyl-2'-deoxycytidine (5mdC, a product of methylated DNA). In this study, adult male mice were exposed to 450mg di-isobutyl phthalate (DiBP)/(kg·day) via dietary exposure for 28days. Mono-isobutyl phthalate (MiBP, the urinary metabolite) and reproductive function parameters were determined...
November 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29191127/the-association-between-the-environmental-endocrine-disruptor-bisphenol-a-and-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#16
Ying Hu, Shu Wen, Dongzhi Yuan, Le Peng, Rujun Zeng, Zhilan Yang, Qi Liu, Liangzhi Xu, Deying Kang
OBJECTIVE: To investigate the association between bisphenol A (BPA) and polycystic ovary syndrome (PCOS). METHODS: A systematic review and meta-analysis using STATA software for observational studies. RESULTS: Nine studies involving 493 PCOS patients and 440 controls were included in this review. The meta-analysis demonstrated that PCOS patients had significantly higher BPA levels compared with control groups (standardized mean difference (SMD): 2...
November 30, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29190551/predictors-and-correlations-of-phthalate-metabolite-concentrations-in-urine-and-seminal-plasma-among-reproductive-aged-men
#17
Yi-Xin Wang, Chong Liu, Ying-Jun Chen, Heng-Gui Chen, Pan Yang, Peng Wang, Li-Li Huang, Song-Hua Ai, Peng Duan, An Pan, Qiang Zeng, Wen-Qing Lu
BACKGROUND: Certain phthalates are suspected to be endocrine disruptors that are adversely associated with male reproductive health. However, the predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among reproductive-aged men have not been thoroughly studied. OBJECTIVE: To investigate the predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among adult Chinese males. METHOD: We measured mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), monomethyl phthalate (MMP), monoethyl phthalate (MEP), mono-n-octyl phthalate (MOP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) concentrations in seminal plasma and repeated spot-urine samples from 687 men who visited a reproductive center...
November 27, 2017: Environmental Research
https://www.readbyqxmd.com/read/29187361/diet-dependence-of-metabolic-perturbations-mediated-by-the-endocrine-disruptor-tolylfluanid
#18
Shane Regnier, Andrew Kirkley, Daniel Ruiz, Wakanene Kamau, Qian Wu, Kurunthachalam Kannan, Robert Sargis
Emerging evidence implicates environmental endocrine disrupting chemicals (EDCs) in the pathogenesis of metabolic diseases such as obesity and diabetes; however, the interactions between EDCs and traditional risk factor in disease pathogenesis remain incompletely characterized. The present study interrogates the interaction of the EDC tolylfluanid (TF) and traditional dietary stressors in the promotion of metabolic dysfunction. Eight-week old, male C57BL/6 mice were fed a high fat-high sucrose diet (HFHSD) or a high sucrose diet (HSD), with or without TF supplementation at 100 μg/g, for 12 weeks...
November 29, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29173116/3-nitro-1-2-4-triazol-5-one-2014
#19
(no author information available yet)
3-Nitro-1,2,4-triazol-5-one (NTO) is a potential replacement for energetics in military munitions. It is a component of IMX-101, a munition designed to prevent unintentional detonation. This report summarizes the dermal, oral, and inhalation animal toxicity data, including the results of genotoxicity and limited reproductive and developmental studies. NTO has an acute LD50 in rats and mice of >5000 mg/kg, is a potential eye and skin irritant, but does not induce skin sensitization. Acute inhalation toxicity studies in rats were negative, but testicular hypoplasia was observed in a 14-day oral study in rats administered NTO at >500 mg/kg/day...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29173038/state-of-the-art-of-the-environmental-behaviour-and-removal-techniques-of-the-endocrine-disruptor-3-4-dichloroaniline
#20
Andrea Luca Tasca, Ashleigh Fletcher
In recent years, the presence of Endocrine Disrupting Chemicals (EDCs) in wastewater discharges from agricultural and industrial sources, [1] fresh- and estuarine-waters, as well as soils, has been reported in the literature. [2] Studies of adverse changes in wildlife, linked to environmental exposure to these substances, and the suggestion that humans could also be at similar risk of adverse health effects, [3-5] have raised concern for urgent action to understand and reduce such risks. 3,4-Dichloroaniline (3,4-DCA) has been recognized as an EDC, with regards to endocrine disruption data for both wildlife populations and human health...
November 27, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
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