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https://www.readbyqxmd.com/read/29678520/sorafenib-suppresses-tgf-%C3%AE-responses-by-inducing-caveolae-lipid-raft-mediated-internalization-degradation-of-cell-surface-type-ii-tgf-%C3%AE-receptors-implications-in-development-of-effective-adjunctive-therapy-for-hepatocellular-carcinoma
#1
Chih-Ling Chung, Shih-Wei Wang, Wei-Chih Sun, Chih-Wen Shu, Yu-Chen Kao, Meng-Shin Shiao, Chun-Lin Chen
Sorafenib is the only FDA approved drug for the treatment of advanced hepatocellular carcinoma (HCC) and other malignancies. Studies indicate that TGF-β signalling is associated with tumour progression in HCC. Autocrine and paracrine TGF-β promotes tumour growth and malignancy by inducing epithelial-mesenchymal transition (EMT). Sorafenib is believed to antagonize tumour progression by inhibiting TGF-β-induced EMT. It improves survival of patients but HCC later develops resistance and relapses. The underlying mechanism of resistance is unknown...
April 17, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29669061/zearalenone-delays-rat-leydig-cell-regeneration
#2
Songyi Zhou, Yiyan Wang, Leikai Ma, Xianwu Chen, Yao Lü, Fei Ge, Yong Chen, Xiaofang Chen, Qingquan Lian, Xiao-Dong Jin, Ren-Shan Ge
Zearalenone (ZEA), a fungal mycotoxin, is present in a wide range of human foods. By virtual screening, we have identified that ZEA is a potential endocrine disruptor of Leydig cells. The effect of ZEA on Leydig cell development is still unclear. The objective of the present study was to explore whether ZEA affected Leydig cell developmental process and to clarify the underlying mechanism. Adult male Sprague Dawley rats (60 days old) were randomly divided into three groups and these rats received a single intraperitoneal injection of 75 mg/kg ethane dimethane sulfonate (EDS) to eliminate all Leydig cells...
April 16, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29669060/plasticizer-di-2-ethylhexyl-phthalate-induces-epithelial-to-mesenchymal-transition-and-renal-fibrosis-in-vitro-and-in-vivo
#3
Cheng-Tien Wu, Ching-Chia Wang, Li-Chen Huang, Shing-Hwa Liu, Chih-Kang Chiang
Plasticizer di-(2-ethylhexyl)phthalate (DEHP) is known as an endocrine disruptor and a peroxisome proliferator. A currently epidemiological study has suggested that daily high di-(2-ethylhexyl)phthalate (DEHP) intake from phthalate-tainted foods in children may be a risk factor for renal dysfunction. DEHP can leach from medical devices such as blood storage bags and the tubing. Long-term exposure to DEHP is associated with nephropathy and exacerbates chronic kidney diseases (CKD) progression. However, the detailed effects and molecular mechanisms remain unclear...
April 14, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29666409/exposure-to-phthalate-an-endocrine-disrupting-chemical-alters-the-first-trimester-placental-methylome-and-transcriptome-in-women
#4
N M Grindler, L Vanderlinden, R Karthikraj, K Kannan, S Teal, A J Polotsky, T L Powell, I V Yang, T Jansson
Phthalates are known endocrine disruptors and associated with decreased fecundity, pregnancy loss, and adverse obstetrical outcomes, however the underlying mechanisms remain to be established. Environmental factors can influence gene expression and cell function by modifying epigenetic marks, impacting the developing embryo as well as future generations of offspring. The impact of phthalates on placental gene methylation and expression is largely unknown. We studied the effect of maternal phthalate exposure on the human placental DNA methylome and transcriptome...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665462/urinary-phthalate-metabolites-and-environmental-phenols-in-university-students-in-south-china
#5
Xue-Mei Zhang, Xiang-Ying Lou, Liu-Hong Wu, Cong Huang, Da Chen, Ying Guo
In China, university students have unique lifestyles compared with the rest of the youth population, as they are almost entirely isolated in campuses. The number of university students is large, and since students represent the future of human reproduction, exposure to environmental endocrine disruptors (EEDs) may have a large impact on society. In this study, levels of several EEDs, including phthalate metabolites, parabens, bisphenol A (BPA) and its analogues, triclosan (TCS), and benzophenone-3, were determined in 169 urine samples collected from university students in Guangzhou, South China...
April 14, 2018: Environmental Research
https://www.readbyqxmd.com/read/29665328/effects-of-exposure-to-acetaminophen-and-ibuprofen-on-fetal-germ-cell-development-in-both-sexes-in-rodent-and-human-using-multiple-experimental-systems
#6
Pablo Hurtado-Gonzalez, Richard A Anderson, Joni Macdonald, Sander van den Driesche, Karen Kilcoyne, Anne Jørgensen, Chris McKinnell, Sheila Macpherson, Richard M Sharpe, Rod T Mitchell
BACKGROUND: Analgesic exposure during pregnancy may affect aspects of fetal gonadal development that are targeted by endocrine disruptors. OBJECTIVES: We investigated whether therapeutically relevant doses of acetaminophen and ibuprofen affect germ cell (GC) development in human fetal testes/ovaries using in vitro and xenograft approaches. METHODS: Gonocyte (TFAP2C+ ) number was reduced relative to controls in first-trimester human fetal testes exposed in vitro to acetaminophen (-28%) or ibuprofen (-22%) and also in ovaries exposed to acetaminophen (-43%) or ibuprofen (-49%)...
April 16, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29663635/di-2-ethylhexyl-phthalate-dehp-induced-testicular-toxicity-through-nrf2-mediated-notch1-signaling-pathway-in-sprague-dawley-rats
#7
Xiangliang Tang, Shengde Wu, Lianju Shen, Yi Wei, Xining Cao, Yangcai Wang, Chunlan Long, Yue Zhou, Dian Li, Fangyuan Huang, Bo Liu, Guanghui Wei
Di-(2-ethylhexyl) phthalate (DEHP) is an environmental endocrine disruptor widely used in China that is harmful to the male reproductive system. Many studies have shown that DEHP causes testicular toxicity through oxidative stress, but the specific mechanism is unknown. Because the Notch pathway is a key mechanism for regulating cell growth and proliferation, we investigated whether Notch is involved in DEHP-induced testicular toxicity and whether vitamins E and C could rescue testicular impairment in Sprague-Dawley (SD) rats...
April 16, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29660719/assessment-of-endocrine-disruptors-effects-on-zebrafish-danio-rerio-embryos-by-untargeted-lc-hrms-metabolomic-analysis
#8
Elena Ortiz-Villanueva, Joaquim Jaumot, Rubén Martínez, Laia Navarro-Martín, Benjamin Piña, Romà Tauler
Bisphenol A (BPA), perfluorooctane sulfonate (PFOS), and tributyltin (TBT) are emerging endocrine disruptors (EDCs) with still poorly defined mechanisms of toxicity and metabolic effects in aquatic organisms. We used an untargeted liquid chromatography-high resolution mass spectrometry (LC-HRMS) metabolomic approach to study the effects of sub-lethal doses of these three EDCs on the metabolic profiles of zebrafish embryos exposed from 48 to 120hpf (hours post fertilization). Advanced chemometric data analysis methods were used to reveal effects on the subjacent regulatory pathways...
April 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29658361/myd88-as-a-therapeutic-target-for-inflammatory-lung-diseases
#9
Franco Di Padova, Valerie F J Quesniaux, Bernhard Ryffel
Introduction Myeloid differentiation primary response protein 88 (MyD88) is a critical adaptor protein involved in Toll-like and IL-1 receptor family signaling controlling innate immune responses and inflammation. Genetic deletion of MyD88 function results in profound suppression of inflammation and reduced resistance of the host to pathogens indicating non-redundant roles of MyD88. The TIR domain is critical for MyD88 dimerization and signaling for TLR and IL-1R family receptor. Areas covered Emerging evidence suggests that chemical disruption of the TIR domain attenuates cell activation and inhibits in vivo MyD88-dependent inflammation...
April 16, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29656166/identification-of-molt-inhibiting-hormone-and-ecdysteroid-receptor-cdna-sequences-in-gammarus-pulex-and-variations-after-endocrine-disruptor-exposures
#10
Eric Gismondi
In amphipods, growth, development and reproduction are mediated by the molt, which is a hormonally controlled process and which, therefore, could be impacted by endocrine disruption compounds (EDC). The molt process is controlled by both X-organ (XO) and Y-organ (YO) through a variety of hormones and receptors including the molt-inhibiting hormone (MIH) and the ecdysteroid receptor (EcR). However, although many studies were devoted to characterize MIH and EcR in crustaceans, only few works evaluated their variations under EDCs exposures...
April 12, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29655848/impacts-of-exogenous-pollutant-bisphenol-a-on-characteristics-of-soybeans
#11
Xingyi Li, Lihong Wang, Fei Shen, Qing Zhou, Xiaohua Huang
Bisphenol A (BPA) is an endocrine disruptor that is ubiquitous in the environment. Previous studies have focused on the effects of BPA on plants to assess the ecological risk of BPA in the environment. To evaluate the effects of BPA on plant biological characters more systematically, we investigated the biological characters of above-ground and under-ground organs of soybean plants exposed to BPA. Meanwhile, the mechanisms for the observed changes were also analyzed from the view of hormone levels and photosynthesis...
April 12, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29653385/histological-and-ultrastructural-alterations-of-the-italian-newt-lissotriton-italicus-skin-after-exposure-to-ecologically-relevant-concentrations-of-nonylphenol-ethoxylates
#12
Elvira Brunelli
Nonylphenol ethoxylates (NPEs) are well known endocrine disruptors. Widespread environmental contamination from NPEs is an issue of great concern. Despite amphibians are often exposed to such contaminants, very little attention has been dedicated to this vertebrate group. No information is available on the effects of NPEs onto the amphibian skin and only few reports have been conducted on fish. Here, histological and ultrastructural modifications of the skin have been evaluated in the Italian newt Lissotriton italicus...
April 7, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29650969/akaps-pka-disruptors-increase-aqp2-activity-independently-of-vasopressin-in-a-model-of-nephrogenic-diabetes-insipidus
#13
Fumiaki Ando, Shuichi Mori, Naofumi Yui, Tetsuji Morimoto, Naohiro Nomura, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Yoshiaki Kondo, Hiroyuki Kagechika, Shinichi Uchida
Congenital nephrogenic diabetes insipidus (NDI) is characterized by the inability of the kidney to concentrate urine. Congenital NDI is mainly caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R), leading to impaired aquaporin-2 (AQP2) water channel activity. So far, treatment options of congenital NDI either by rescuing mutant V2R with chemical chaperones or by elevating cyclic adenosine monophosphate (cAMP) levels have failed to yield effective therapies. Here we show that inhibition of A-kinase anchoring proteins (AKAPs) binding to PKA increases PKA activity and activates AQP2 channels in cortical collecting duct cells...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29649501/exposure-to-endocrine-disruptors-17alpha-ethinylestradiol-and-estradiol-influences-cytochrome-p450-1a1-mediated-genotoxicity-of-benzo-a-pyrene-and-expression-of-this-enzyme-in-rats
#14
Marie Stiborová, Helena Dračínská, Lucie Bořek-Dohalská, Zuzana Klusoňová, Jana Holecová, Markéta Martínková, Heinz H Schmeiser, Volker M Arlt
Endocrine disruptors (EDs) are compounds that interfere with the balance of the endocrine system by mimicking or antagonising the effects of endogenous hormones, by altering the synthesis and metabolism of natural hormones, or by modifying hormone receptor levels. The synthetic estrogen 17α-ethinylestradiol (EE2) and the environmental carcinogen benzo[a]pyrene (BaP) are exogenous EDs whereas the estrogenic hormone 17β-estradiol is a natural endogenous ED. Although the biological effects of these individual EDs have partially been studied previously, their toxicity when acting in combination has not yet been investigated...
April 9, 2018: Toxicology
https://www.readbyqxmd.com/read/29648919/oligomers-of-styrene-are-not-endocrine-disruptors
#15
Heinz-Peter Gelbke, Marcy Banton, Christian Block, Gordon Dawkins, Edgar Leibold, Mark Pemberton, Atsunobu Sakoda, Atsushi Yasukawa
Oligomers of styrene have been identified in polystyrene (PS) polymer samples intended for food packaging. Such oligomers contribute to nonintentionally added substances (NIAS) that may migrate into food or food simulants and therefore have to be assessed for the potential risk to health. No oligomers larger than dimers and trimers of styrene have been found to be present in PS. Some in vivo and in vitro information indicative of an endocrine activity for some specific oligomers suggest concerns for their potential for endocrine disruption in humans...
April 12, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29627878/discovery-of-a-small-molecule-inhibitor-of-dvl-cxxc5-interaction-by-computational-approaches
#16
Songling Ma, Jiwon Choi, Xuemei Jin, Hyun-Yi Kim, Ji-Hye Yun, Weontae Lee, Kang-Yell Choi, Kyoung Tai No
The Wnt/β-catenin signaling pathway plays a significant role in the control of osteoblastogenesis and bone formation. CXXC finger protein 5 (CXXC5) has been recently identified as a negative feedback regulator of osteoblast differentiation through a specific interaction with Dishevelled (Dvl) protein. It was reported that targeting the Dvl-CXXC5 interaction could be a novel anabolic therapeutic target for osteoporosis. In this study, complex structure of Dvl PDZ domain and CXXC5 peptide was simulated with molecular dynamics (MD)...
April 7, 2018: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/29627606/gestational-exposure-to-ziram-disrupts-rat-fetal-leydig-cell-development
#17
Jianpeng Liu, Yiyan Wang, Yinghui Fang, Chaobo Ni, Leikai Ma, Wenwen Zheng, Suhao Bao, Xiaoheng Li, Qingquan Lian, Ren-Shan Ge
Ziram is an endocrine disruptor and may cause birth abnormality of the male reproductive system. However, the effects of ziram on fetal Leydig cell (FLC) development are still unknown. The objective of the present study was to determine the endocrine-disrupting effect of ziram on rat FLC development after gestational exposure. Pregnant Sprague Dawley dams were randomly divided into 5 groups and were gavaged with 0 (corn oil, the control), 1, 2, 4, or 8 mg/kg ziram from gestational day 12 (GD12) to GD21. FLC development was evaluated by measuring serum testosterone, FLC number and distribution, and the expression levels of Leydig and Sertoli cell genes...
March 21, 2018: Chemosphere
https://www.readbyqxmd.com/read/29627534/assessment-of-the-effects-of-discontinuous-sources-of-contamination-through-biomarker-analyses-on-caged-mussels
#18
A De Los Ríos, B Echavarri-Erasun, M-H Dévier, K Le Menach, H Budzinski, M Ortiz-Zarragoitia, A Orbea, J A Juanes, M P Cajaraville
The present study analysed potential adverse effects of discontinuous sources of contamination, namely the discharge of a combined sewer overflow (CSO) and of runoff in an urban area, the Bay of Santander (North Iberian Peninsula). Water samples and caged mussels were used to analyse concentrations of contaminants and biological responses. Mussels (Mytilus galloprovincialis) were transplanted to a marina receiving runoff from a petrol station and to a CSO discharge site. Samples were collected in synchrony with heavy rains along 62days...
April 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29626202/endocrine-disruptors-putting-the-mechanistic-cart-before-the-phenomenological-horse
#19
Ana M Soto, Carlos Sonnenschein
No abstract text is available yet for this article.
April 6, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29625398/estradiol-shapes-mutualistic-behaviour-of-female-cleaner-fish-labroides-dimidiatus-valenciennes-1839-potential-implications-of-environmental-disturbance
#20
Murilo S Abreu, João P M Messias, Ana C V V Giacomini, Marta C Soares
The presence of endocrine-derived compounds in the environment occurs due to a myriad of human or industrial activity and can disrupt the endocrine system of animals, including fish. One important group of endocrine disruptors are the estrogens, such as 17-β estradiol (E2 , estradiol). Estrogens are gonadal steroid hormones, able to be influential even in small concentrations. Here, we demonstrate that E2 is linked to female' decisions made by an important coral reef species, the cleaner fish Labroides dimidiatus, during interactions with other reef fishes (known as clients)...
April 3, 2018: Ecotoxicology and Environmental Safety
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