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https://www.readbyqxmd.com/read/29443748/ultrasound-combined-with-fine-needle-aspiration-cytology-for-the-assessment-of-axillary-lymph-nodes-in-patients-with-early-stage-breast-cancer
#1
Fan Zhang, Jing Zhang, Qing-Xin Meng, Xin Zhang
This study aimed to explore the clinical usefulness of ultrasound-guided fine needle aspiration cytology (USG-FNAC) for the evaluation of axillary lymph nodes in patients with early stage breast cancer (BC) among the Chinese Han female population.Around 124 patients with early stage BC were included in this retrospective study. All patients underwent USG-FNAC (group A). Patients with proven metastasis also underwent axillary lymph node dissection (ALND) (group B). In addition, sentinel lymph node biopsy (SLNB) was performed 2 to 5 hours prior to the surgery...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442155/outcomes-and-prognostic-factors-of-selective-lateral-pelvic-lymph-node-dissection-with-preoperative-chemoradiotherapy-for-locally-advanced-rectal-cancer
#2
Takeru Matsuda, Yasuo Sumi, Kimihiro Yamashita, Hiroshi Hasegawa, Masashi Yamamoto, Yoshiko Matsuda, Shingo Kanaji, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
PURPOSE: The clinical significance of preoperative chemoradiotherapy (CRT) and lateral lymph node dissection (LLND) for locally advanced rectal cancer remains unclear. We have employed total mesorectal excision and selective LLND following preoperative CRT for patients with locally advanced rectal cancer. The validity of our strategy was evaluated. METHODS: A total of 45 patients with locally advanced rectal cancer who underwent curative surgery after CRT from November 2005 to September 2016 were retrospectively analyzed...
February 13, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29441833/role-of-number-of-sentinel-nodes-in-predicting-non-sentinel-node-metastasis-in-breast-cancer
#3
Li-Feng Dong, Shu-Ying Xu, Jing-Pei Long, Fang Wan, Yi-Ding Chen
Objective The aim of the present study was to determine how many sentinel lymph nodes (SLNs) are appropriate for predicting non-SLN metastasis in breast cancer. Methods The association between clinicopathological features and non-SLN metastasis was retrospectively analyzed in 472 patients who underwent axillary lymph node dissection (ALND) following SLN biopsy. Another 251 patients who underwent only SLN biopsy without ALND were analyzed and followed up for 2 years. Results A large tumor size, positive SLN, and HER-2 positivity were independent predictors of non-SLN metastasis...
February 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29440931/influential-factors-on-radiotherapy-efficacy-and-prognosis-in-patients-with-secondary-lymph-node-metastasis-after-esophagectomy-of-thoracic-esophageal-squamous-cell-carcinoma
#4
Shao-Bing Zhou, Xin-Wei Guo, Liang Gu, Sheng-Jun Ji
Background: The purpose of this study was to clarify whether pretreatment tumor burden-related index, including the gross tumor volume (GTV) of metastatic lymph nodes (V LN ) and maximum diameter of metastatic lymph nodes (D LN ), and inflammatory markers, consisting of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), are useful for assessing the therapeutic effects and prognosis with secondary lymph node metastasis (LNM) receiving chemoradiotherapy (CRT) or radiotherapy (RT) alone after resection of esophageal squamous cell carcinoma (ESCC)...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29439716/risk-factors-of-lateral-lymph-node-metastasis-in-cn0-papillary-thyroid-carcinoma
#5
Daixing Hu, Jing Zhou, Wei He, Jie Peng, Yijia Cao, Haoyu Ren, Yu Mao, Yi Dou, Wei Xiong, Qi Xiao, Xinliang Su
BACKGROUND: Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central lymph node (CLN) dissection or lateral lymph node (LLN) dissections to prevent metastasis is still controversial. This study aimed to retrospectively investigate the risk factors of LLN metastasis in clinical lymph node-negative (cN0) PTC patients. METHODS: We retrospectively studied 783 lymph node-negative (cN0) PTC patients who underwent total thyroidectomy plus CLN dissection and LLN dissection...
February 13, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29439612/a-nomogram-based-on-the-characteristics-of-metastatic-lymph-nodes-to-predict-papillary-thyroid-carcinoma-recurrence
#6
Jianyong Lei, Jinjing Zhong, Zhihui Li, Tao Wei, Rixiang Gong, Jinqiang Zhu
BACKGROUND AND AIMS: The extent of metastatic LN invasion was not considered in the postoperative stratification of the recurrence risk of papillary thyroid carcinoma (PTC) in the 2015 American Thyroid Association (ATA) guidelines, and the recommended risk stratification cannot be applied to individuals. A nomogram based on these risk factors was developed based on the risk factors to predict individual recurrence risk. PATIENTS AND METHODS: Data from 1788 PTC patients at the West China Hospital and 306 cases from the Shang Jin Nan Fu Hospital between August 2013 and July 2015 were included in our study...
February 14, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29438531/characteristics-of-follicular-variant-papillary-thyroid-carcinoma-in-a-pediatric-cohort
#7
S L Samuels, L F Surrey, C P Hawkes, M Amberge, S Mostoufi-Moab, J E Langer, N S Adzick, K Kazahaya, T Bhatti, Z Baloch, V A LiVolsi, A J Bauer
Context: In adults, non-invasive follicular variant papillary thyroid carcinoma (FVPTC) is considered low risk for metastasis and persistent/recurrent disease. Objective: The goal of this study was to assess the clinical, sonographic, and histopathological features of FVPTC in a pediatric cohort. Design: A retrospective review of subjects < 19 years of age with papillary thyroid carcinoma (PTC) who underwent thyroidectomy between January 2010 and July 2015...
February 8, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29438363/cd9-positive-exosomes-from-cancer-associated-fibroblasts-stimulate-the-migration-ability-of-scirrhous-type-gastric-cancer-cells
#8
Yuichiro Miki, Masakazu Yashiro, Tomohisa Okuno, Kishu Kitayama, Go Masuda, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Crosstalk between cancer cells and fibroblasts is crucial for tumour progression. It has been reported that exosomes derived from cancer cells play an important role in the intracellular communications involved in the development of carcinoma. However, the role of exosomes from fibroblasts remains unclear. This study aimed to clarify the effect of exosomes from fibroblasts on the motility of gastric cancer cells. METHODS: 5 gastric cancer cell lines were used: OCUM-12, NUGC-3, MKN45, FU97 and MKN74...
February 13, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29436630/silencing-of-b7-h4-suppresses-the-tumorigenicity-of-the-mgc-803-human-gastric-cancer-cell-line-and-promotes-cell-apoptosis-via-the-mitochondrial-signaling-pathway
#9
Donghui Zhou, Yong Zhou, Chao Li, Lina Yang
B7-H4 is a transmembrane protein which is a member of the B7 superfamily. It is overexpressed in various types of cancer, including gastric cancer. However, the effects of B7-H4 on the tumorigenicity of gastric cancer and the underlying mechanisms have not yet been fully explored. Thus, the aim of this study was to examine the effects of B7-H4 on the tumorigenicity of gastric cancer cells and to elucidate the underlying mechanisms. For this purpose, B7-H4 expression in gastric cancer tissues was detected by immunohistochemical staining...
February 13, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29436615/identification-and-validation-of-the-role-of-matrix-metalloproteinase-1-in-cervical-cancer
#10
Run Tian, Xiaofang Li, Yan'e Gao, Yue Li, Pei Yang, Kunzheng Wang
Lymph node (LN) metastasis at an early stage of cervical cancer is often an indicator of poor prognosis and is critical for subsequent adjuvant therapy. The current study aimed to identify aberrant gene signatures and biomarkers of metastasis for patients with cervical cancer. RNA-sequencing data of 132 LN negative (N0) and 60 LN positive (N1) cervical cancer samples obtained from The Cancer Genome Atlas database were analyzed. Differentially expressed genes were identified using R packages 'edgeR' and 'limma'...
February 7, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29435872/a-phase-ii-trial-of-concurrent-chemoradiotherapy-with-weekly-paclitaxel-and-carboplatin-in-advanced-oesophageal-carcinoma
#11
Kuai-Le Zhao, Yi Xia, Yun-Hai Li, Yun Chen, Qi Liu, Jun-Hua Zhang, Jia-Ying Deng, Ta-Shan Ai, Han-Ting Zhu, Harun Badakhshi
BACKGROUND: This study was performed to assess the efficacy and feasibility of definitive chemoradiotherapy consisting of weekly doses of combined paclitaxel and carboplatin concurrent with radiation therapy, followed by 2 cycles of consolidation chemotherapy for advanced esophageal carcinoma. METHODS: Eligibility criteria included local, advanced, newly diagnosed and postoperative local regional lymph node metastasis; Eastern Cooperative Oncology Group (ECOG) score ≤ 2; and adequate organ function...
February 12, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29435302/retrospective-analysis-of-surgery-for-cervical-stump-carcinoma-at-early-stage
#12
Zhen Shen, Ying Zhou, Yong Cheng, Min Li, Dabao Wu
Cervical stump cancer is a rare type of disease as total hysterectomies are performed infrequently. The purpose of this retrospective study was to assess the diagnosis, treatment, follow-up methods and complications of 10 patients with cervical stump carcinoma treated with surgery in Anhui Provincial Hospital affiliated to Anhui Medical University (Hefei, China). From January 2006 to October 2016 a total of 10 patients underwent surgery for carcinoma of the cervical stump. The pathological reports revealed 80% of cases were squamous cell carcinoma and 20% of cases were adenocarcinoma...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29435289/outcomes-of-abdominal-esophageal-cancer-patients-who-were-treated-with-esophagectomy
#13
Hiroyuki Kitagawa, Tsutomu Namikawa, Jun Iwabu, Kazune Fujisawa, Michiya Kobayashi, Kazuhiro Hanazaki
The aim of the present study was to elucidate the characteristics and outcomes of abdominal esophageal cancer patients who were treated with esophagectomy. The records of 210 esophagectomy patients were retrospectively reviewed and the differences in postoperative outcomes and disease-specific survival between squamous cell carcinoma and adenocarcinoma were evaluated. Of the 20 abdominal esophageal cancer patients, 11 had squamous cell carcinoma, 8 had adenocarcinoma and 1 had adenosquamous cell carcinoma. The body mass index and serum albumin levels were significantly lower in the squamous cell carcinoma patients compared with those in the adenocarcinoma patients, and abdominal lymph node metastasis was significantly more frequent in the adenocarcinoma patients...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29435285/significance-of-lung-biopsy-for-the-definitive-diagnosis-of-lung-nodules-in-breast-cancer-patients
#14
Kazuo Matsuura, Toshiyuki Itamoto, Midori Noma, Masahiro Ohara, Etsushi Akimoto, Mihoko Doi, Takashi Nishisaka, Koji Arihiro, Takayuki Kadoya, Morihito Okada
The aim of the present study was to evaluate the significance of lung biopsy for the modification of the treatment strategy in breast cancer patients who develop lung nodules during follow-up after breast surgery. Of 53 consecutive patients who underwent lung biopsies in two institutions (Hiroshima University Hospital and Hiroshima Prefectural Hospital, Hiroshima, Japan) between 1997 and 2014, 45 underwent lung surgery and 8 underwent percutaneous or transbronchial tumor biopsy for lung nodules developing after curative surgery for breast cancer...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29435188/a-meta-analysis-of-the-lymphatic-microvessel-density-and-survival-in-gastric-cancer-with-1809-cases
#15
Liang Liang, Wen-Ting Huang, Rong-Quan He, Hai-Wei Liang, Chun-Qin Huang, Hong Zhou, Fang-Lin Wei, Sheng-Sheng Zhou, Zhi-Gang Peng, Gang Chen, Jun-Qiang Chen, Xin-Gan Qin
Lymph node metastasis commonly occurs in gastric cancer. Previous studies have demonstrated that the overexpression of lymphatic microvessel density (LVD) is correlated with various malignancies. To evaluate the potential role of LVD in various malignancies, we conducted a systematic review and meta-analysis to thoroughly investigate the association of LVD expression with tumor progression and survival in gastric cancer. We performed a comprehensive search of common databases and selected studies demonstrating the relationship between LVD expression and gastric cancer prognosis...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435168/low-fat4-expression-is-associated-with-a-poor-prognosis-in-gastric-cancer-patients
#16
Xiaoting Jiang, Zhengchuang Liu, Yingjie Xia, Jungang Luo, Ji Xu, Xujun He, Houquan Tao
In this study, we investigated the role of Fat atypical cadherin 4 (FAT4) in gastric cancer (GC) progression. Immunohistochemical analysis showed lower FAT4 expression in tumor tissues from GC patients than in normal gastric epithelium. Lower FAT4 expression was associated with poor prognosis, tumor size and invasion, and lymph node and distant metastases. Multivariate analysis showed that TNM stage, lymph node and distant metastases, Lauren classification, and FAT4 expression were independent prognostic factors in GC...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435106/overexpression-of-%C3%AE-1-integrin-contributes-to-polarity-reversal-and-a-poor-prognosis-of-breast-invasive-micropapillary-carcinoma
#17
Bingbing Liu, Xia Zheng, Fanfan Meng, Yunwei Han, Yawen Song, Fangfang Liu, Shuai Li, Lanjing Zhang, Feng Gu, Xinmin Zhang, Li Fu
Invasive micropapillary carcinoma (IMPC) of the breast is a highly aggressive breast cancer. Polarity reversal exemplified by cluster growth is hypothesized to contribute to the invasiveness and metastasis of IMPC. In this study, we demonstrate that levels of β1 integrin and Rac1 expression were greater in breast IMPC than in invasive breast carcinoma of no specific type and paraneoplastic benign breast tissue. We show that silencing β1 integrin expression using the β1 integrin inhibitor AIIB2 partially restored polarity in IMPC primary cell clusters and downregulated Rac1...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435059/macc1-and-hgf-are-associated-with-survival-in-patients-with-gastric-cancer
#18
Guokai Dong, Man Wang, Guangfu Gu, Shanshan Li, Xiaoming Sun, Zhouru Li, Hongxing Cai, Zhengqiu Zhu
Metastasis-associsated in colon cancer 1 (MACC1), a newly identified oncogene, promotes tumor cell proliferation and invasion. In the present study, the expression of MACC1, hepatocyte growth factor (HGF) and its receptor, MET proto-oncogene (c-Met), was investigated in human gastric cancer tissues and adjacent normal tissues by immunohistochemistry. The association between the expression levels of the proteins and the clinicopathological parameters of the tumors were statistically analyzed. Furthermore, lentiviral particles expressing MACC1 were used to infect the hepatic satellite cell (HSC) line LX2...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29435035/expression-of-proteins-associated-with-epithelial-mesenchymal-transition-in-esophageal-squamous-cell-carcinoma
#19
Tian Zhang, Hao Li, Yang Zhang, Pei Wang, Huijie Bian, Zhi-Nan Chen
Cluster of differentiation 147 (CD147), pituitary tumor transforming gene (PTTG) and CD44v6 are proteins involved in the epithelial-mesenchymal transition (EMT). To investigate the prognostic value of CD147 and PTTG, and CD44v6 expression in esophageal squamous cell carcinoma (ESCC), tissue microarray specimens from 76 patients with ESCC were evaluated by immunohistochemistry staining and scored by intensity and proportion of positive areas. Expression levels of CD147, PTTG and CD44v6 were higher in tumor tissues than in matched adjacent tissues...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29435024/expression-of-ezh2-is-associated-with-poor-outcome-in-colorectal-cancer
#20
Zhuanpeng Chen, Ping Yang, Wanglin Li, Feng He, Jianchang Wei, Tong Zhang, Junbin Zhong, Huacui Chen, Jie Cao
Enhancer of zeste homolog 2 (EZH2), the critical component of polycomb group protein family, has been demonstrated to be overexpressed in various types of human cancer, including hepatocellular carcinoma, breast, bladder and lung cancer. The mechanism of how EZH2 promotes oncogenesis has also been well studied. However, little is known about the role of EZH2 in colorectal cancer (CRC). The main purpose of the present study was to analyze the association between EZH2 expression and the clinicopathological features of CRC...
March 2018: Oncology Letters
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