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https://www.readbyqxmd.com/read/28817272/cysteine-isocyanide-in-multicomponent-reaction-synthesis-of-peptido-mimetic-1-3-azoles
#1
Thimmalapura M Vishwanatha, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander Dömling
An alternative approach towards the simple and robust synthesis of highly substituted peptidic thiazole derivatives by using Ugi-multicomponent reaction (U-MCR) is described. Thus, we introduced the enantiopure (R)-2-methyl-2-isocyano-3-(tritylthio)propanoate as novel class of isocyanide in MCR. This bifunctional isocyanide was found to undergo mild cyclodehydration to afford thiazole containing peptidomimetics in a short synthetic sequence. Several examples of bis-heterocyclic rings were also synthesized through the proper choice of the aldehyde component in the U-4CR...
August 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28816439/1-3-dipolar-cycloaddition-reactions-for-the-synthesis-of-novel-oxindole-derivatives-and-their-cytotoxic-properties
#2
Prakash Rambhau Mali, Prashishkumar Kisan Shirsat, Navnath Bapurao Khomane, V Lakshama Nayak, Jagadeesh Babu Nanubolu, Harshadas Mitaram Meshram
The multicomponent reaction between isatin, amino acid, but-2-ynedioates and phenacyl bromide has been developed using microwave irradiation under catalyst and base free conditions in aqueous medium. This synthetic protocol is useful for the synthesis of various functionalized spirooxindole derivatives. This MCR exhibits a broad substrate scope with excellent yields and shorter reaction time. Additionally the synthesized spirooxindole derivatives were evaluated for their anticancer activity against three human cancer cell lines; MCF-7 (breast), A549 (lung) and Hela cervical...
August 17, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28811346/erratum-for-yin-et-al-novel-plasmid-mediated-colistin-resistance-gene-mcr-3-in-escherichia-coli
#3
Wenjuan Yin, Hui Li, Yingbo Shen, Zhihai Liu, Shaolin Wang, Zhangqi Shen, Rong Zhang, Timothy R Walsh, Jianzhong Shen, Yang Wang
No abstract text is available yet for this article.
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28811031/bayesian-approach-to-peak-deconvolution-and-library-search-for-high-resolution-gas-chromatography-mass-spectrometry
#4
A Barcaru, H G J Mol, M Tienstra, G Vivó-Truyols
A novel probabilistic Bayesian strategy is proposed to resolve highly coeluting peaks in high-resolution GC-MS (Orbitrap) data. Opposed to a deterministic approach, we propose to solve the problem probabilistically, using a complete pipeline. First, the retention time(s) for a (probabilistic) number of compounds for each mass channel are estimated. The statistical dependency between m/z channels was implied by including penalties in the model objective function. Second, Bayesian Information Criterion (BIC) is used as Occam's razor for the probabilistic assessment of the number of components...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28807400/incx3-plasmid-harboring-a-non-tn4401-genetic-element-ntekpc-in-a-hospital-associated-clone-of-kpc-2-producing-klebsiella-pneumoniae-st340-cg258
#5
Louise T Cerdeira, Marcos P V Cunha, Gabriela R Francisco, Maria Fernanda C Bueno, Bruna F Araujo, Rosineide M Ribas, Paulo P Gontijo-Filho, Terezinha Knöbl, Doroti de Oliveira Garcia, Nilton Lincopan
IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most blaKPC- and blaNDM-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTEKPC) of tnpR-tnpA (partial)-blaKPC-2-ΔISKpn6/traN, originating from a hospital-associated lineage of K...
July 1, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28805746/melanocortins-melanocortin-receptors-and-multiple-sclerosis
#6
REVIEW
Robert P Lisak, Joyce A Benjamins
The melanocortins and their receptors have been extensively investigated for their roles in the hypothalamo-pituitary-adrenal axis, but to a lesser extent in immune cells and in the nervous system outside the hypothalamic axis. This review discusses corticosteroid dependent and independent effects of melanocortins on the peripheral immune system, central nervous system (CNS) effects mediated through neuronal regulation of immune system function, and direct effects on endogenous cells in the CNS. We have focused on the expression and function of melanocortin receptors in oligodendroglia (OL), the myelin producing cells of the CNS, with the goal of identifying new therapeutic approaches to decrease CNS damage in multiple sclerosis as well as to promote repair...
August 14, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28799833/plasmid-mediated-colistin-resistance-gene-mcr-1-in-an-escherichia-coli-st10-bloodstream-isolate-in-the-sultanate-of-oman
#7
Jalila Mohsin, Tibor Pál, Jorgen Eskild Petersen, Dania Darwish, Akela Ghazawi, Tanveer Ashraf, Agnes Sonnevend
AIMS: To identify plasmid-mediated colistin resistance in clinical Enterobacteriaceae isolates in Oman, where this resistance mechanism has not been encountered yet. MATERIALS/METHODS: Twenty-two colistin-resistant Enterobacteriaceae clinical isolates collected between July 2014 and June 2016 in a tertiary care hospital in Muscat were screened by PCR for the mcr-1 and mcr-2 genes. The strain identified as mcr-1 positive was genotyped and its antibiotic susceptibility was established...
August 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28797329/novel-plasmid-mediated-colistin-resistance-mcr-4-gene-in-salmonella-and-escherichia-coli-italy-2013-spain-and-belgium-2015-to-2016
#8
Alessandra Carattoli, Laura Villa, Claudia Feudi, Ludovica Curcio, Serenella Orsini, Andrea Luppi, Giovanni Pezzotti, Chiara Francesca Magistrali
A novel mcr colistin resistance gene was identified in a strain of Salmonella enterica, monophasic variant of serovar Typhimurium (4,5,12:i:- ), isolated from a pig at slaughter in Italy in 2013, and in Escherichia coli strains collected during routine diagnostic of post-weaning diarrhoea in pigs from Spain and Belgium in 2015 and 2016. Immediate implementation of mcr-screening including this novel gene variant is required for Salmonella and E. coli from humans and food-producing animals in Europe.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797328/co-occurrence-of-colistin-resistance-genes-mcr-1-and-mcr-3-among-multidrug-resistant-escherichia-coli-isolated-from-cattle-spain-september-2015
#9
Marta Hernández, M Rocío Iglesias, David Rodríguez-Lázaro, Alejandro Gallardo, Narciso Quijada, Pedro Miguela-Villoldo, Maria Jorge Campos, Segundo Píriz, Gema López-Orozco, Cristina de Frutos, José Luis Sáez, María Ugarte-Ruiz, Lucas Domínguez, Alberto Quesada
Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. The sequences of both genes hybridised to same plasmid band of ca 250 kb, although colistin resistance was non-mobilisable. The isolate was producing extended-spectrum beta-lactamases and belonged to serotype O9:H10 and sequence type ST533. Here we report an mcr-3 gene detected in Europe following earlier reports from Asia and the United States.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797325/plasmid-borne-colistin-resistance-gene-mcr-3-in-salmonella-isolates-from-human-infections-denmark-2009-17
#10
Eva Litrup, Kristoffer Kiil, Anette M Hammerum, Louise Roer, Eva M Nielsen, Mia Torpdahl
This report describes one Salmonella isolate harbouring both mcr-1 and mcr-3. We also found nine other Salmonella isolates positive for the plasmid-borne colistin resistance gene, mcr-3. The strains were isolated from patients in Denmark between 2009 and 2017 and five of the patients had travelled to Asia. In addition to mcr-3, all strains were found positive for blaTEM-1, strA, strB, sul2 and tet(A) or tet(B), and most strains were positive for blaCTX-M-55 and qnrS.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797324/novel-mcr-3-variant-encoding-mobile-colistin-resistance-in-an-st131-escherichia-coli-isolate-from-bloodstream-infection-denmark-2014
#11
Louise Roer, Frank Hansen, Marc Stegger, Ute Wolff Sönksen, Henrik Hasman, Anette M Hammerum
A novel variant of the plasmid-borne colistin resistance gene mcr-3 was detected on an IncHI2 plasmid in an ST131 CTX-M-55-producing Escherichia coli isolate from a Danish patient with bloodstream infection in 2014. The discovery of novel plasmid-borne genes conferring resistance to colistin is of special interest since colistin has reemerged as an important drug in the treatment of infections with multidrug-resistant Gram-negative bacteria.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797321/plasmid-encoded-colistin-resistance-mcr-one-two-three-and-counting
#12
EDITORIAL
Jan Kluytmans
No abstract text is available yet for this article.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28796128/high-intensity-interval-exercises-acute-impact-on-heart-rate-variability-comparison-between-whole-body-and-cycle-ergometer-protocols
#13
Gustavo Z Schaun, Fabrício B Del Vecchio
Study aimed to compare the effects of two high-intensity interval exercises (HIIT) protocols on heart rate variability (HRV). Twelve young adult males (23.3 ± 3.9 years, 177.8 ± 7.4 cm, 76.9 ± 12.9 kg) volunteered to participate. In a randomized cross-over design, subjects performed two HIIT protocols, one on a cycle ergometer (TBT; eight 20 s bouts at 170% Pmax interspersed by 10 s rest) and another with whole-body calisthenic exercises (MCR; eight 20 s all-out intervals interspersed by 10 s rest). HRV outcomes in the time, frequency and non-linear domains were assessed on three moments: (a) pre-session; (b) immediately post-session; and (c) 24h post-session...
August 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28794569/cortisol-homeostasis-in-the-epidermis-is-influenced-by-topical-corticosteroids-in-patients-with-atopic-dermatitis
#14
Mototsugu Fukaya
BACKGROUND: The skin produces cortisol by itself and regulates its own proliferation and differentiation. There is a possibility that topical corticosteroids (TCSs) influence the cortisol homeostasis in the skin. AIMS AND OBJECTIVES: The author described the density and distribution of cortisol and its parties in the epidermis after application of topical steroids immunohistologically. MATERIALS AND METHODS: The forearm skin was biopsied before and after 2 weeks' application of clobetasol propionate 0...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28783436/a-multi-channel-open-tubular-enzyme-reactor-on-line-coupled-with-mass-spectrometry-for-detecting-ricin
#15
Ole Kristian Brandtzæg, Bent Tore Røen, Siri Enger, Elsa Lundanes, Steven Ray Wilson
For counter-terrorism purposes, a selective nano liquid chromatography-mass spectrometry (nanoLC-MS) platform was developed for detecting the highly lethal protein ricin from castor bean extract. Manual sample preparation steps were omitted by implementing a trypsin/Lys C enzyme-immobilized multi-channel reactor (MCR) consisting of 126 channels (8 µm inner diameter in all channels) that performed on-line digestion of proteins (5 minute reaction time, instead of 4-16 hours in previous in-solution methods). Reduction and alkylation steps were not required...
August 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28782705/investigation-of-potential-risk-factors-for-the-occurrence-of-escherichia-coli-isolates-from-german-fattening-pig-farms-harbouring-the-mcr-1-colistin-resistance-gene
#16
Katja Hille, Nicole Roschanski, Inga Ruddat, Johanna Woydt, Maria Hartmann, Uwe Rösler, Lothar Kreienbrock
Within the scope of a cross-sectional investigation on fattening pig farms conducted in 2011 and 2012, 48 fattening farms in different agricultural regions of Germany were studied. Primary cultures of boot swabs and collective faecal samples were stored at -80°C and screened for the presence of the mcr-1 colistin resistance gene. The laboratory results were linked to farm related data collected via questionnaire. We used logistic regression models to investigate the association between occurrence of mcr-1 and farm related data...
August 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28780361/untreated-urban-waste-contaminates-indian-river-sediments-with-resistance-genes-to-last-resort-antibiotics
#17
Nachiket P Marathe, Chandan Pal, Swapnil S Gaikwad, Viktor Jonsson, Erik Kristiansson, D G Joakim Larsson
Efficient sewage treatment is critical for limiting environmental transmission of antibiotic-resistant bacteria. In many low and middle income countries, however, large proportions of sewage are still released untreated into receiving water bodies. In-depth knowledge of how such discharges of untreated urban waste influences the environmental resistome is largely lacking. Here, we highlight the impact of uncontrolled discharge of partially treated and/or untreated wastewater on the structure of bacterial communities and resistome of sediments collected from Mutha river flowing through Pune city in India...
July 25, 2017: Water Research
https://www.readbyqxmd.com/read/28780246/detection-and-genetic-features-of-mcr-1-producing-plasmid-in-human-escherichia-coli-infection-in-south-korea
#18
Eun Sil Kim, Yong Pil Chong, Su-Jin Park, Mi-Na Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Jin-Yong Jeong, Yang Soo Kim
The plasmid-mediated colistin resistance gene, mcr-1, was identified for the first time from a hospitalized patient in South Korea. The mcr-1 gene was successfully transferred to E. coli J53 recipient and conferred resistance to colistin in the recipient. The mcr-1-harboring plasmid possessed a typical IncI2 group and did not have the mcr-1-associated ISApl1 element.
July 2, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28780184/emergence-of-a-colistin-resistant-escherichia-coli-clinical-isolate-harboring-mcr-1-in-japan
#19
Tatsuya Tada, Kohei Uechi, Isamu Nakasone, Kayo Shimada, Masashi Nakamatsu, Teruo Kirikae, Jiro Fujita
The mcr-1 is a gene encoding a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. We describe here the emergence of a colistin-resistant Escherichia coli clinical isolate harboring plasmid-mediated mcr-1 in Japan. The isolate belonged to ST5702 and is suspected to come from livestock and transmitted to human. This is the first report of a clinical isolate harboring mcr-1 in Japan.
August 2, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28777086/1-12%C3%A2-%C3%A3-resolution-crystal-structure-of-the-catalytic-domain-of-the-plasmid-mediated-colistin-resistance-determinant-mcr-2
#20
Katie Coates, Timothy R Walsh, James Spencer, Philip Hinchliffe
MCR-2 confers resistance to colistin, a `last-line' antibiotic against extensively resistant Gram-negative pathogens. It is a plasmid-encoded phosphoethanolamine transferase that is closely related to MCR-1. To understand the diversity in the MCR family, the 1.12 Å resolution crystal structure of the catalytic domain of MCR-2 was determined. Variable amino acids are located distant from both the di-zinc active site and the membrane-proximal face. The exceptionally high resolution will provide an accurate starting model for further mechanistic studies...
August 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
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