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https://www.readbyqxmd.com/read/29741092/advancing-peptide-based-biorecognition-elements-for-biosensors-using-in-silico-evolution
#1
Xingqing Xiao, Zhifeng Kuang, Joseph M Slocik, Sirimuvva Tadepalli, Michael Brothers, Steve S Kim, Peter A Mirau, Claire Butkus, Barry L Farmer, Srikanth Singamaneni, Carol K Hall, Rajesh R Naik
Sensors for human health and performance monitoring require biological recognition elements (BREs) at device interfaces for the detection of key molecular biomarkers that are measurable biological state indicators. BREs, including peptides, antibodies, and nucleic acids, bind to biomarkers in the vicinity of the sen-sor surface to create a signal proportional to the biomarker con-centration. The discovery of BREs with the required sensitivity and selectivity to bind biomarkers at low concentrations re-mains a fundamental challenge...
May 9, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29684784/pilot-scale-outdoor-production-of-scenedesmus-sp-in-raceways-using-flue-gases-and-centrate-from-anaerobic-digestion-as-the-sole-culture-medium
#2
Ahlem Jebali, F Gabriel Acién, Erika Rodriguez Barradas, Eugenia J Olguín, Sami Sayadi, Emilio Molina Grima
This work investigated the production of Scenedesmus sp. in semi-continuous mode in three pilot-scale outdoor raceways (7.2 m2 ) using flue gas for CO2 supply and centrate from the anaerobic digestion of urban wastewater as the sole nutrient source. Experiments were performed at different culture depths, 5, 10 and 15 cm, while evaluating two centrate concentrations (30% and 45%) at dilution rates of 0.2 and 0.3 d-1 . Under optimal conditions of 30% centrate, 0.3 d-1 dilution rate and a 15 cm culture depth, a maximum biomass productivity of 22...
April 17, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29675386/comparison-of-myopia-control-between-toric-and-spherical-periphery-design-orthokeratology-in-myopic-children-with-moderate-to-high-corneal-astigmatism
#3
Yu Zhang, Yue-Guo Chen
AIM: To compare clinical results between toric and spherical periphery design orthokeratology (ortho-k) in myopic children with moderate-to-high corneal astigmatism. METHODS: This retrospective study enrolled 62 eyes of 62 subjects using toric ortho-k lenses. These subjects were assigned to the toric group. Based on the one-to-one match principle (same age, proximate spherical equivalence and corneal astigmatism), 62 eyes of 62 subjects were enrolled and included in the spherical group...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29672058/anticorrelated-contributions-to-pre-edge-features-of-aluminate-near-edge-x-ray-absorption-spectroscopy-in-concentrated-electrolytes
#4
Andrew Wildman, Ernesto Martinez-Baez, John L Fulton, Gregory K Schenter, Carolyn I Pearce, Aurora Evelyn Clark, Xiaosong Li
Ion pairing within complex solutions and elec- trolytes is a difficult phenomenon to mea- sure and investigate, yet it has signicant im- pact upon macroscopic processes, such as crys- tal formation. Traditional methods of detect- ing and characterizing ion pairing are sensi- tive to contact ion pairs, may require min- imum concentrations that limit applicability, and can have difficulty in characterizing solu- tions with many components. Because of its element specicity and sensitivity to local en- vironment, X-ray absorption near edge struc- ture (XANES) is a promising tool for investi- gating ion pairing in complex solutions...
April 19, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29669368/-capsulorhexis-real-life-experienced-surgeon-versus-femto-laser-assisted-cataract-surgery-flacs-as-reported-in-literature
#5
Frank Sachers, David Goldblum
BACKGROUND: Capsulorhexis is one of the most important steps in cataract surgery. Good centration, circular overlap in sufficient size and a circular edge without tears result in good centration of the intraocular lens (IOL). In this study, the capsulorhexis results of an experienced surgeon are compared with reported data in femtolaser assisted cataract surgery (FLACS). PATIENTS AND METHODS: 105 consecutive operations were photographically documented; in 81 cases size and overlap were analysed retrospectively...
April 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29658266/enzyme-based-electrochemical-biosensor-for-therapeutic-drug-monitoring-of-anticancer-drug-irinotecan
#6
Maria Domenica Alvau, Stefano Tartaggia, Anna Meneghello, Bruno Casetta, Giammario Calia, Pier Andrea Serra, Federico Polo, Giuseppe Toffoli
Therapeutic drug monitoring (TDM) is the clinical practice of measuring pharmaceutical drug concentrations in patients' biofluids at designated intervals, thus allowing a close and timely control of their dosage. To date, TDM in oncology can only be performed by trained personnel in centralized laboratories and core facilities employing conventional analytical techniques (e.g. MS). CPT-11 is an antineoplastic drug that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer...
April 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29649690/effects-of-sludge-enhanced-aeration-on-nutrient-contents-and-phytotoxicity-of-anaerobically-digested-centrate
#7
Wenhai Luo, Bangxi Zhang, Yanmeng Bi, Guoxue Li, Qiaoping Sun
In this study, we investigated the impact of intensive aeration pre-treatment on nutrient contents and phytotoxicity of anaerobically digested manure centrate. Activated sludge from conventional wastewater treatment plants was added to reinforce the aeration process. Results show that the addition of activated sludge did not negatively affect the nutrient contents, but significantly reduced the phytotoxicity of digested centrate, as indicated by an enhancement of seed germination index, during the aeration treatment...
March 26, 2018: Chemosphere
https://www.readbyqxmd.com/read/29569063/-arthroscopic-double-row-reconstruction-of-high-grade-subscapularis-tendon-tears
#8
F Plachel, S Pauly, P Moroder, M Scheibel
OBJECTIVE: Reconstruction of tendon integrity to maintain glenohumeral joint centration and hence to restore shoulder functional range of motion and to reduce pain. INDICATIONS: Isolated or combined full-thickness subscapularis tendon tears (≥upper two-thirds of the tendon) without both substantial soft tissue degeneration and cranialization of the humeral head. CONTRAINDICATIONS: Chronic tears of the subscapularis tendon with higher grade muscle atrophy, fatty infiltration, and static decentration of the humeral head...
March 22, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29560716/experimental-and-theoretical-investigation-of-the-function-of-4-tert-butyl-pyridine-for-interface-energy-level-adjustment-in-efficient-solid-state-dye-sensitized-solar-cells
#9
Lei Yang, Rebecka Lindblad, Erik Gabrielsson, Gerrit Boschloo, Håkan Rensmo, Licheng Sun, Anders Hagfeldt, Tomas Edvinsson, Erik M J Johansson
4-tert-butylpyridine (t-BP) is commonly used in solid state dye-sensitized solar cells (ssDSSCs) to increase the photo-voltaic performance. In this report, the mechanism how t-BP functions as a favorable additive is investigated compre-hensively. ssDSSCs were prepared with different concentration of t-BP and a clear increase in efficiency was observed up to a maximum concentration and for higher concentrations the efficiency thereafter decreases. The energy level alignment in the complete devices was measured using hard X-ray photoelectron spectroscopy (HAXPES)...
March 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29522225/the-sensitivity-of-clinical-outcomes-to-centration-on-the-light-constricted-pupil-for-a-shape-changing-corneal-inlay
#10
Enrique Barragán-Garza, Douglas D Koch, Luis G Vargas, Alan Lang, Adam Roy
PURPOSE: To assess the clinically acceptable range of inlay decentration with respect to the light-constricted pupil center and the coaxially sighted corneal light reflex (CSCLR) for an inlay (Raindrop Near Vision Inlay; ReVision Optics, Inc., Lake Forest, CA) that reshapes the anterior corneal surface. METHODS: In this retrospective, observational cohort study of 115 patients with emmetropic or low hyperopic presbyopia who were implanted with a shape-changing corneal inlay, visual acuity, task performance (in good and dim light), reports of halos and glare, and satisfaction data were collected from the preoperative and 3-month postoperative examinations...
March 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29522224/clinical-outcomes-of-smile-with-a-triple-centration-technique-and-corneal-wavefront-guided-transepithelial-prk-in-high-astigmatism
#11
Ikhyun Jun, David Sung Yong Kang, Dan Z Reinstein, Samuel Arba-Mosquera, Timothy J Archer, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To comparatively investigate the clinical outcomes, vector parameters, and corneal aberrations of small incision lenticule extraction (SMILE) with a triple centration technique and corneal wavefront-guided transepithelial photorefractive keratectomy (PRK) for the correction of high astigmatism. METHODS: This retrospective, comparative case series study included 89 eyes (89 patients) that received treatment for myopia with high astigmatism (≥ 2.50 diopters) using SMILE with a triple centration technique (SMILE group; 45 eyes) and corneal wavefront-guided transepithelial PRK (transepithelial PRK group; 44 eyes)...
March 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29521688/keratoprosthesis-decentration-and-tilt-results-in-degradation-in-image-quality
#12
Richard W Helms, Xiaowei Zhao, Rony R Sayegh
PURPOSE: To study the effect of decentration and tilt of the type I Boston keratoprosthesis (KPro) on image quality in both aphakic and pseudophakic eyes. METHODS: An optical ray-tracing program was used to simulate the image projected onto the retina in an eye with a perfectly centered KPro, and in eyes with varying degrees of KPro decentration and tilt. Decentration was modeled along a typical white-to-white distance of 12.0 mm, and the corresponding tilt was calculated assuming a radius of curvature of 8...
June 2018: Cornea
https://www.readbyqxmd.com/read/29521095/miniaturized-reverse-electrodialysis-powered-biosensor-using-electrochemiluminescence-on-bipolar-electrode
#13
Seol Baek, Seung-Ryong Kwon, Song Yi Yeon, Sun-Heui Yoon, Chung Mu Kang, Seok Hee Han, Dahye Lee, Taek Dong Chung
We suggest an electrochemiluminescence (ECL)-sensing platform driven by ecofriendly, disposable, and miniaturized reverse electrodialysis (RED) patches as an electric power source. The flexible RED patches composed of ion-exchange membranes (IEMs) can produce voltage required for ECL sensing by simply choosing the appropriate number of IEMs and the ratio of salt concentrations. We integrate the RED patch with a bipolar electrode on the microfluidic chip to demonstrate the proof-of-concept, i.e., glucose detection in the range of 0...
April 3, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29505257/bioregeneration-of-chabazite-during-nitrification-of-centrate-from-anaerobically-digested-livestock-waste-experimental-and-modeling-studies
#14
Verónica E Aponte-Morales, Karl A Payne, Jeffrey A Cunningham, Sarina J Ergas
Nitrification of high total ammonia nitrogen-strength wastewaters is challenging due to free ammonia (FA) inhibition of nitrification. FA inhibition can potentially be alleviated by temporarily adsorbing ammonium (NH4 + ) to natural zeolite, such as chabazite, followed by direct zeolite bioregeneration via nitrification. In this research, the effectiveness of chabazite addition for reducing nitrification inhibition during treatment of centrate from anaerobic digestion of swine waste was quantified. A mathematical model was developed that accounts for ion exchange of NH4 + and sodium at the chabazite surface, surface diffusion of adsorbed NH4 + within the chabazite grains, sequential nitrification of aqueous NH4 + to nitrite and nitrate, and inhibition of nitritation and nitratation rates by NH4 + ...
April 3, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29478228/high-dietary-iron-differentially-influences-the-iron-distribution-in-the-livers-and-the-spleens-of-laying-hens-after-salmonella-typhimurium-infection
#15
Shiping Bai, Keying Zhang, Xuemei Ding, Jianping Wang, Qiufeng Zeng, Huanwei Peng, Yue Xuan, Zuowei Su, Jie Bai
Salmonella and the host battle for iron (Fe), due to its importance for fundamental cellular processes. To investigate Fe redistribution of Salmonella-infected hens and the effects of high dietary Fe on it, Salmonella-free hens were randomly assigned to 1 of 4 treatments in 2 (two dietary Fe level) × 2 (Salmonella-inoculation or -noninoculation) factorial assignment. After feeding a basal diet supplemented with 60 (adequate, control) or 300 mg Fe/kg (high-Fe) for 4 weeks, 59-week-old Salmonella-free hens were orally inoculated with 5 × 107 colony-forming units of Salmonella Typhimurium (infection) or PBS (vehicle)...
February 24, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29477062/bioaugmentation-of-sidestream-nitrifying-denitrifying-phosphorus-accumulating-granules-in-a-low-srt-activated-sludge-system-at-low-temperature
#16
Bryce A Figdore, H David Stensel, Mari-Karoliina H Winkler
Sidestream granular activated sludge grown on anaerobic digester dewatering centrate was bioaugmented and selectively retained to enable high nitrification performance of a 2.5-day aerobic SRT non-nitrifying flocculent activated sludge system at 12 °C. Sidestream-grown granules performed enhanced biological phosphorus removal (EBPR) and short-cut nitrogen removal via nitrite. After bioaugmentation, EBPR continued in the mainstream but ammonia oxidation was eventually to nitrate. Low effluent NH3 -N concentrations from 0...
May 15, 2018: Water Research
https://www.readbyqxmd.com/read/29454922/nutrient-recovery-from-wastewater-through-pilot-scale-electrodialysis
#17
Andrew J Ward, Kimmo Arola, Emma Thompson Brewster, Chirag M Mehta, Damien J Batstone
Nutrient recovery performance utilising an electrodialysis (ED) process was quantified in a 30-cell pair pilot reactor with a 7.2 m2 effective membrane area, utilising domestic anaerobic digester supernatant, which had been passed through a centrifuge as a feed source (centrate). A concentrated product (NH4 -N 7100 ± 300 mg/L and K 2490 ± 40 mg/L) could be achieved by concentrating nutrient ions from the centrate wastewater dilute feed stream to the product stream using the ED process. The average total current efficiency for all major cations over the experimental period was 76 ± 2% (NH4 -N transport 40%, K transport 14%)...
May 15, 2018: Water Research
https://www.readbyqxmd.com/read/29425391/incidence-and-outcomes-of-optical-zone-enlargement-and-recentration-after-previous-myopic-lasik-by-topography-guided-custom-ablation
#18
Dan Z Reinstein, Timothy J Archer, Glenn I Carp, Alastair J Stuart, Elizabeth L Rowe, Andrew Nesbit, Tara Moore
PURPOSE: To report the incidence, visual and refractive outcomes, optical zone enlargement, and recentration using topography-guided CRS-Master TOSCA II software with the MEL 80 excimer laser (Carl Zeiss Meditec AG, Jena, Germany) after primary myopic laser refractive surgery. METHODS: Retrospective analysis of 73 eyes (40 patients) with complaints of night vision disturbances due to either a decentration or small optical zone following a primary myopic laser refractive surgery procedure using the MEL 80 laser...
February 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29408060/utilization-of-centrate-from-urban-wastewater-plants-for-the-production-of-scenedesmus-sp-in-a-raceway-simulating-reactor
#19
Ahlem Jebali, F Gabriel Acién, Sami Sayadi, Emilio Molina-Grima
This work investigates the production of the native microalgae strain Scenedesmus sp. in semi-continuous mode at lab scale in open raceway-simulating reactors and using centrate as the culture medium. The biomass productivity and nutrient removal capacity of Scenedesmus sp. at different dilution rates were investigated indoors as well as its tolerance to centrate as the culture medium at different concentrations. A biomass productivity of 7.80 g/m2  day was obtained at 200 μE/m2  s, 5 cm culture depth, 0...
April 1, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29403227/evaluation-of-the-relevance-of-piaget-s-cognitive-principles-among-parented-and-orphan-children-in-belagavi-city-karnataka-india-a-comparative-study
#20
Chandrashekhar M Badakar, Prachi J Thakkar, Shivayogi M Hugar, Pratibha Kukreja, Harsha G Assudani, Niraj Gokhale
Aim: To determine and compare the relevance of Piaget's cognitive principles among 4- to 7-year-old parented and orphan children in Belagavi City, Karnataka, India. Materials and methods: This study was conducted on 240 children between the ages of 4 to 7 years who were equally divided into two groups of 120 parented and 120 orphan children. These were subdivided into four groups of 30 children each. Various characteristics like egocentrism, concept of cardinal numbers based on centration, lack of conservation, and reversibility were assessed, using experiments and comparison of their prevalence between two groups was carried out...
October 2017: International Journal of Clinical Pediatric Dentistry
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