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https://www.readbyqxmd.com/read/29912303/early-juvenile-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-study-of-25-patients
#1
Cinthya Maria Neves Varandas, José Lucas Sena da Silva, Janeusa Rita L Primo, Maria de Fátima S P de Oliveira, Otávio Moreno-Carvalho, Lourdes Farre, Achiléa L Bittencourt
Background: HTLV-1 may cause severe diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated to HTLV-1 (IDH). The clinical characteristics and progression of 25 early onset HAM/TSP associated or not to IDH were described. Methods: Following-up 37 IDH patients with neurological examinations, 54% developed HAM/TSP. To these cases were added five cases of juvenile HAM/TSP. The patients were HTLV-1+ and were submitted to dermatological and neurological examinations...
April 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29872426/comprehensive-antiretroviral-restriction-factor-profiling-reveals-the-evolutionary-imprint-of-the-ex-vivo-and-in-vivo-ifn-%C3%AE-response-in-htlv-1-associated-neuroinflammation
#2
Fabio E Leal, Soraya Maria Menezes, Emanuela A S Costa, Phillip M Brailey, Lucio Gama, Aluisio C Segurado, Esper G Kallas, Douglas F Nixon, Tim Dierckx, Ricardo Khouri, Jurgen Vercauteren, Bernardo Galvão-Castro, Rui Andre Saraiva Raposo, Johan Van Weyenbergh
HTLV-1-Associated Myelopathy (HAM/TSP) is a progressive neuroinflammatory disorder for which no disease-modifying treatment exists. Modest clinical benefit from type I interferons (IFN-α/β) in HAM/TSP contrasts with its recently identified IFN-inducible gene signature. In addition, IFN-α treatment in vivo decreases proviral load and immune activation in HAM/TSP, whereas IFN-β therapy decreases tax mRNA and lymphoproliferation. We hypothesize this "IFN paradox" in HAM/TSP might be explained by both cell type- and gene-specific effects of type I IFN in HTLV-1-associated pathogenesis...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29867836/future-perspectives-on-drug-targeting-in-adult-t-cell-leukemia-lymphoma
#3
REVIEW
Francesca Marino-Merlo, Antonio Mastino, Sandro Grelli, Olivier Hermine, Ali Bazarbachi, Beatrice Macchi
Human T cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia/lymphoma (ATL), HTLV-1 associated myelopathy (HAM/TSP), and of a number of inflammatory diseases with an estimated 10-20 million infected individuals worldwide. Despite a number of therapeutic approaches, a cure for ATL is still in its infancy. Conventional chemotherapy has short-term efficacy, particularly in the acute subtype. Allogeneic stem cell transplantation offers long-term disease control to around one third of transplanted patients, but few can reach to transplant...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29867783/-ifng-874a-t-polymorphism-among-asymptomatic-htlv-1-infected-individuals-is-potentially-related-to-a-worse-prognosis
#4
Maria A F Queiroz, Vânia N Azevedo, Ednelza da S G Amoras, Tuane C F Moura, Marluísa de O Guimarães Ishak, Ricardo Ishak, Antonio C R Vallinoto, Rosimar N Martins Feitosa
HTLV-1 infections are persistent and frequently latent; however, productive infections trigger different types of immunological responses that utilize cytokines to control infection. The present study investigated the role of IFNG +874A/T polymorphisms among 153 HTLV-1-infected individuals (33 clinically diagnosed with TSP/HAM, 22 with rheumatologic manifestations, 2 with dermatitis, 1 with uveitis, and 95 asymptomatic patients) and 300 healthy control individuals. Genotyping and proviral HTLV-1 load assessment were performed using real-time PCR assays, and the plasma levels of IFN-γ were measured using an enzyme immunoassay (ELISA)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29768555/the-relationship-between-atopy-and-neurological-manifestations-in-htlv-1-infection
#5
Raquel Crisóstomo Lima Verde, José Abraão Carneiro Neto, Silvane Maria Braga Santos, Edgar Marcelino Carvalho, Marcus Miranda Lessa
INTRODUCTION: Human T-cell lymphotropic virus type 1 (HTLV-1)induces exaggerated Th1 responses, whereas atopy is associated with exacerbated Th2 responses. METHODS: Here, a cross-sectional study compared the prevalence of atopy in HTLV-1 carriers and HAM/TSP patients. It also compared the spontaneous cytokine production in HTLV-1-infected individuals. A retrospective cohort study evaluated the development of neurological manifestations in atopic and non-atopic carriers...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29768548/balance-functional-mobility-and-fall-occurrence-in-patients-with-human-t-cell-lymphotropic-virus-type-1-associated-myelopathy-tropical-spastic-paraparesis-a-cross-sectional-study
#6
Erika Pedreira da Fonseca, Katia Nunes Sá, Rebeca Freitas Reis Nunes, Antônio Carlos Ribeiro Junior, Síntia Freitas Bastos Lira, Elen Beatriz Pinto
INTRODUCTION: Human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) may lead to reduced functional mobility and balance. It is important to establish specific parameters that identify these changes and predict the risk of falls in these patients. The aim was to compare balance, functional mobility, and occurrence of falls among patients with and without HAM/TSP and to suggest values to predict the risk of falls in these patients. METHODS: A cross-sectional study in patients with and without HAM/TSP involved balance assessments based on the berg balance scale (BBS) and functional mobility evaluation based on the timed up and go (TUG) test...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29709026/immunophenotypic-characterization-of-csf-b-cells-in-virus-associated-neuroinflammatory-diseases
#7
Yoshimi Enose-Akahata, Shila Azodi, Bryan R Smith, Bridgette Jeanne Billioux, Ashley Vellucci, Nyater Ngouth, Yuetsu Tanaka, Joan Ohayon, Irene Cortese, Avindra Nath, Steven Jacobson
Intrathecal antibody synthesis is a well-documented phenomenon in infectious neurological diseases as well as in demyelinating diseases, but little is known about the role of B cells in the central nervous systems. We examined B cell and T cell immunophenotypes in CSF of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) compared to healthy normal donors and subjects with the other chronic virus infection and/or neuroinflammatory diseases including HIV infection, multiple sclerosis (MS) and progressive multifocal leukoencephalopathy...
April 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29593659/how-to-control-htlv-1-associated-diseases-preventing-de-novo-cellular-infection-using-antiviral-therapy
#8
Amandine Pasquier, Sandrine Alais, Loic Roux, Maria-Isabel Thoulouze, Karine Alvarez, Chloé Journo, Hélène Dutartre, Renaud Mahieux
Five to ten million individuals are infected by Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 is transmitted through prolonged breast-feeding, by sexual contacts and by transmission of infected T lymphocytes through blood transfusion. One to ten percent of infected carriers will develop a severe HTLV-1-associated disease: Adult-T-cell leukemia/lymphoma (ATLL), or a neurological disorder named Tropical Spastic Paraparesis/HTLV-1 Associated Myelopathy (TSP/HAM). In vivo , HTLV-1 is mostly detected in CD4+ T-cells, and to a lesser extent in CD8+ T cells and dendritic cells...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29589290/htlv-1-proviral-load-in-cerebrospinal-fluid-may-not-be-a-good-marker-to-differentiate-asymptomatic-carriers-with-high-proviral-load-in-blood-from-ham-tsp-patients
#9
Marina Lobato Martins, Anna Bárbara de Freitas Carneiro-Proietti, Rodrigo Nicolato, Débora Marques de Miranda, Luiz Cláudio Ferreira Romanelli
An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL quantified in cerebrospinal fluid (CSF) is helpful to distinguish AC from HAM when AC have high PVL in blood (ACH ). ACH (n = 7) were characterized to have high PVL in blood by quantification of samples collected over time (mean 7 years)...
March 27, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29581472/proteomic-analysis-of-plasma-extracellular-vesicles-reveals-mitochondrial-stress-upon-htlv-1-infection
#10
Patricia Jeannin, Thibault Chaze, Quentin Giai Gianetto, Mariette Matondo, Olivier Gout, Antoine Gessain, Philippe V Afonso
Extracellular vesicles (EVs) can participate in intercellular communication and pathogenesis. EVs contain many cargos, including proteins, and the composition of EVs differs between cell-types and activation levels. Thus, plasma EVs can be used as a biomarker of systemic response to infection and/or disease progression. In this study, we aimed at describing alterations in the protein content of plasma EVs upon infection with the human T-lymphotropic retrovirus type 1 (HTLV-1). HTLV-1 is the etiological agent of a lymphoproliferative disease (ATL) and a series of inflammatory diseases, including a neurodegenerative inflammatory disease (HAM/TSP)...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29558516/low-genetic-diversity-of-the-human-t-cell-lymphotropic-virus-htlv-1-in-an-endemic-area-of-the-brazilian-amazon-basin
#11
Akim Felipe Santos Nobre, Danilo de Souza Almeida, Louise Canto Ferreira, Deimy Lima Ferreira, Edivaldo Costa Sousa Júnior, Maria de Nazaré do Socorro de Almeida Viana, Ingrid Christiane Silva, Bruna Teles Pinheiro, Stephen Francis Ferrari, Alexandre da Costa Linhares, Edna Aoba Ishikawa, Rita Catarina Medeiros Sousa, Maísa Silva de Sousa
The Human T-cell Lymphotropic Virus (HTLV-1) is a Deltaretrovírus that was first isolated in the 1970s, and associated with Adult T-cell Leucemia-Lymphoma (ATLL), and subsequently to Tropical Spastic Paraparesis-Myelopathy (TSP/HAM). The genetic diversity of the virus varies among geographic regions, although its mutation rate is very low (approximately 1% per thousand years) in comparison with other viruses. The present study determined the genetic diversity of HTLV-1 in the metropolitan region of Belém, in northern Brazil...
2018: PloS One
https://www.readbyqxmd.com/read/29554087/temporal-trends-in-human-t-lymphotropic-virus-1-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-incidence-in-martinique-over-25-years-1986-2010
#12
Stephane Olindo, Severine Jeannin, Martine Saint-Vil, Aissatou Signate, Mireille Edimonana-Kaptue, Julien Joux, Harold Merle, Pascale Richard, Samuel Granjeaud, Philippe Cabre, Didier Smadja, Raymond Cesaire, Agnes Lezin
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) has been discovered in 1980 and has been linked to tropical spastic paraparesis (HAM/TSP) in 1985 in Martinique. There is no data on HAM/TSP incidence trends. We report, in the present work, the temporal trends incidence of HAM/TSP in Martinique over 25 years. METHODS: Martinique is a Caribbean French West Indies island deserved by a unique Neurology Department involved in HAM/TSP diagnosis and management. A registry has been set up since 1986 and patients diagnosed for a HAM/TSP were prospectively registered...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29515558/htlv-deregulation-of-the-nf-%C3%AE%C2%BAb-pathway-an-update-on-tax-and-antisense-proteins-role
#13
REVIEW
Stefania Fochi, Simona Mutascio, Umberto Bertazzoni, Donato Zipeto, Maria G Romanelli
Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL), an aggressive CD4+ /CD25+ T-cell malignancy and of a severe neurodegenerative disease, HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). The chronic activation or deregulation of the canonical and non-canonical nuclear factor kappa B (NF-κB) pathways play a crucial role in tumorigenesis. The HTLV-1 Tax-1 oncoprotein is a potent activator of the NF-κB transcription factors and the NF-κB response is required for promoting the development of HTLV-1 transformed cell lines...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29499169/in-vitro-basal-t-cell-proliferation-among-asymptomatic-human-t-cell-leukemia-virus-type-1-patients-co-infected-with-hepatitis-c-and-or-human-immunodeficiency-virus-type-1
#14
Tatiane Assone, Tatiana M Kanashiro, Maira P M Baldassin, Arthur Paiva, Michel E Haziot, Jerusa Smid, Augusto Penalva de Oliveira, Luiz Augusto M Fonseca, Philip J Norris, Jorge Casseb
BACKGROUND: Infection with Human T cell Leukemia Virus type 1 can be associated with myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases. Lymphocytes from about half of Human T cell Leukemia Virus type 1-infected subjects spontaneously proliferate in vitro, and how this phenomenon relates to symptomatic disease and viral burden is poorly understood. OBJECTIVE: To evaluate T-cell proliferation in vitro among patients co-infected with Human T cell Leukemia Virus type 1/Hepatitis C Virus/Human Immunodeficiency Virus type 1...
March 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29473309/efficacy-of-mirabegron-for-overactive-bladder-with-human-t-cell-lymphotropic-virus-1-associated-myelopathy
#15
Tomohiro Matsuo, Yasuyoshi Miyata, Tatsufumi Nakamura, Katsuya Satoh, Hideki Sakai
OBJECTIVE: Mirabegron is widely considered as an effective and safe drug for patients with overactive bladder (OAB). However, there is no evidence regarding the efficacy of mirabegron in human T cell lymphotropic virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients with OAB symptoms. The aim of the present study was to clarify the efficacy of mirabegron in HAM/TSP patients with OAB symptoms. METHODS: The present study evaluated the efficacy of mirabegron treatment (50 mg, once daily) in nineteen HAM/TSP patients with OAB symptoms by assessing subjective symptoms using the overactive bladder symptom score (OABSS) and International Prostate Symptom Score (IPSS) before and 12 weeks after administration...
February 22, 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29462596/onabotulinumtoxin-type-a-improves-lower-urinary-tract-symptoms-and-quality-of-life-in-patients-with-human-t-cell-lymphotropic-virus-type-1-associated-overactive-bladder
#16
Jose Abraão Carneiro Neto, Silvane Braga Santos, Gloria Orge Orge, Davi Tanajura, Lucia Passos, Cassius José Oliveira, Rosana Andrade, Cláudio Galeno de Melo, Ubirajara Barroso, Edgar M Carvalho
AIM: To evaluate the efficacy of the onabotulinum toxin type A in the treatment of HTLV-1 associated overactive bladder and its impact on quality of life (QoL). METHODS: Case series with 10 patients with overactive bladder refractory to conservative treatment with anticholinergic or physical therapy. They received 200Ui of onabotulinumtoxin type A intravesically and were evaluated by overactive bladder symptoms score (OABSS) and King's Health Questionnaire. RESULTS: The mean (SD) of the age was 52+14...
March 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29414279/mogamulizumab-anti-ccr4-in-htlv-1-associated-myelopathy
#17
Tomoo Sato, Ariella L G Coler-Reilly, Naoko Yagishita, Natsumi Araya, Eisuke Inoue, Rie Furuta, Toshiki Watanabe, Kaoru Uchimaru, Masao Matsuoka, Naoki Matsumoto, Yasuhiro Hasegawa, Yoshihisa Yamano
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) causes the debilitating neuroinflammatory disease HTLV-1-associated myelopathy-tropical spastic paraparesis (HAM-TSP) as well as adult T-cell leukemia-lymphoma (ATLL). In patients with HAM-TSP, HTLV-1 infects mainly CCR4+ T cells and induces functional changes, ultimately causing chronic spinal cord inflammation. We evaluated mogamulizumab, a humanized anti-CCR4 monoclonal antibody that targets infected cells, in patients with HAM-TSP...
February 8, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29408825/ligand-activated-peroxisome-proliferator-activated-receptor-%C3%AE-attenuates-vascular-oxidative-stress-by-inhibiting-thrombospondin-1-expression
#18
Min Young Ahn, Sun Ah Ham, Taesik Yoo, Won Jin Lee, Jung Seok Hwang, Kyung Shin Paek, Dae-Seog Lim, Sung Gu Han, Chi-Ho Lee, Han Geuk Seo
Thrombospondin-1 (TSP-1) is implicated in vascular diseases associated with oxidative stress, such as abdominal aortic aneurysms, ischemia-reperfusion injury, and atherosclerosis. However, the regulatory mechanisms underlying TSP-1 expression are not fully elucidated. In this study, we found that peroxisome proliferator-activated receptor δ (PPARδ) inhibited oxidative stress-induced TSP-1 expression and migration in vascular smooth muscle cells (VSMCs). Activation of PPARδ by GW501516, a specific ligand for PPARδ, significantly attenuated hydrogen peroxide (H2O2)-induced expression of TSP-1 in VSMCs...
February 6, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29400072/role-of-integrin-signaling-activation-on-the-development-of-human-t-cell-leukemia-virus-1-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-its-relationship-to-htlv-1-infected-cd4-t-cell-transmigrating-activity-into-the-tissues
#19
Tatsufumi Nakamura, Katsuya Satoh, Hideki Nakamura, Naomi Fukushima, Yoshihiro Nishiura, Takafumi Furuya, Katsuhiro Ichinose
The main clinical feature of human T cell leukemia virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is slowly progressive spastic paraparesis with bladder dysfunction. HAM/TSP is induced by chronic inflammation in the spinal cord, mainly the lower thoracic cord. A long-standing bystander mechanism, such as the destruction of surrounding tissues by the interaction between infiltrated Th1-like, HTLV-1-infected CD4+ T cells and HTLV-1-specific CD8+ cytotoxic T cells (CTL), is probably critical for the induction of chronic inflammation...
April 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29318453/sensory-neuronopathy-heralding-human-t-cell-lymphotropic-virus-type-i-myelopathy
#20
Alberto R M Martinez, Raphael F Casseb, Carlos R Martins, Anamarli Nucci, Marcondes C França
Neurological phenotypes of human T cell lymphotropic virus type I (HTLV-1) are numerous and rarely may not manifest the classic HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We report a case of HTLV-1-related sensory neuronopathy heralding the classic HAM/TSP.
January 9, 2018: Journal of Neurovirology
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