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https://www.readbyqxmd.com/read/27894665/modulatory-effects-of-curcumin-on-apoptosis-and-cytotoxicity-related-molecules-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-patients
#1
Asadollah Mohammadi, Bahare Fazeli, Marzieh Taheri, Amirhossein Sahebkar, Zohreh Poursina, Vida Vakili, Shadi Zamanian Yazdi, Zahra Keramati, Reza Boostani, Ian Hampson, Houshang Rafatpanah
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic viral neuroinflammatory disease. Apoptosis might play an important role in the control of HTLV-1 viral infection. This study aims to determine if apoptosis process being able to occasionally distinguish between asymptomatic carriers (ACs) and HAM/TSP patients. Therefore, it could be used to predict the outcome of HTLV-1 infection. The mRNA expression of perforin, granzyme A, granzyme B, granulysin, Fas-Ligand (FasL), TNF-related apoptosis-inducing ligand (TRAIL), total Fas and membrane Fas in 21 HAM/TSP patients, 21 ACs and 21 healthy controls (HCs) was quantified...
November 25, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27887847/role-of-the-htlv-1-viral-factors-in-the-induction-of-apoptosis
#2
REVIEW
Mohammad Karimi, Hamed Mohammadi, Maryam Hemmatzadeh, Asadollah Mohammadi, Houshang Rafatpanah, Behzad Baradaran
Adult T-cell leukemia (ATL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) are the two main diseases that are caused by the HTLV-1 virus. One of the features of HTLV-1 infection is its resistance against programmed cell death, which maintains the survival of cells to oncogenic transformation and underlies the viruses' therapeutic resistance. Two main genes by which the virus develops cancer are Tax and HBZ; playing an essential role in angiogenesis in regulating viral transcription and modulating multiple host factors as well as apoptosis pathways...
November 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27871430/htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-a-comparative-study-to-identify-factors-that-influence-disease-progression
#3
Eiji Matsuura, Satoshi Nozuma, Yuichi Tashiro, Ryuji Kubota, Shuji Izumo, Hiroshi Takashima
OBJECTIVE: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) can progress slowly or rapidly even though a set of symptoms such as spastic paraparesis with pathological reflexes and sweating loss of the lower extremities are commonly observed in patients. Although most of the patients are thought to be infected to HTLV-1 from their mothers by breast feeding, symptoms of HAM/TSP typically manifest in patients later in life (50-60years old in age) and also with a higher prevalence of women to men at a ratio of approximately 3:1...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27845163/the-effect-of-htlv-1-virulence-factors-hbz-tax-proviral-load-hla-class-i-and-plasma-neopterin-on-manifestation-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis
#4
Hanieh Tarokhian, Mahdi Taghadosi, Hushang Rafatpanah, Taraneh Rajaei, Mahmoud Reza Azarpazhooh, Narges Valizadeh, S A Rahim Rezaee
BACKGROUND: Previous studies have suggested debatable roles of Tax and HBZ gene expression in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this study, HTLV-1 and host interactions in the manifestation of HAM/TSP were evaluated. METHODS: A cross-sectional study was conducted on 33 HAM/TSP patients and 38 HTLV-1 asymptomatic carriers (ACs). HTLV-1-Tax, HBZ gene expression, and proviral load (PVL) were assessed using the quantitative real-time PCR (TaqMan), host plasma neopterin level, and HLA-I, and the clinical manifestation were evaluated...
November 12, 2016: Virus Research
https://www.readbyqxmd.com/read/27787900/evaluation-of-htlv-1-hbz-and-proviral-load-together-with-host-ifn-%C3%AE-3-in-pathogenesis-of-ham-tsp
#5
Sayed Hamid Reza Mozhgani, Najmeh Jaberi, Seyyed Abdolrahim Rezaee, Reza Bustani, Seyyed Mohammad Jazayeri, Mohammad Mahdi Akbarian, Saeideh Milani, Hanieh Tarokhian, Mehdi Norouzi
Human T-cell lymphotropic virus 1 (HTLV-1) is associated with two progressive diseases: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia/lymphoma (ATLL). Although HTLV-1 proviral load (PVL) has been introduced as a risk factor for these diseases' progression, it is not sufficient on its own to yield an accurate estimation of the outcome of the infection. In the present study, PVL and HTLV-1 basic leucine zipper factor (HBZ) expression level as viral factors, and IFN λ3 as a host factor, were evaluated in HAM/TSP patients and HTLV-1 asymptomatic carriers (ACs)...
October 27, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27769524/dynamic-acquisition-of-htlv-1-tax-protein-by-mononuclear-phagocytes-role-in-neurologic-disease
#6
Eiji Matsuura, Yoshimi Enose-Akahata, Karen Yao, Unsong Oh, Yuetsu Tanaka, Hiroshi Takashima, Steven Jacobson
Pathology of HTLV-1 associated myelopathy/Tropical spastic paraparesis (HAM/TSP) is believed to be the result of "bystander damage" involving effector CD8 (+) T lymphocytes (CTLs) killing of virus infected cells. But the specific cellular events leading up to tissue injury are still unclear. Here, we developed the Microscopy Imaging of Cytotoxic T lymphocyte assay with Fluorescence emission (MI-CaFé), an optimized visualization analysis to explore the interactions between CTLs and virus infected or viral antigen presenting target cells...
October 3, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27678093/long-term-follow-up-of-htlv-1-proviral-load-in-asymptomatic-carriers-and-in-incident-cases-of-ham-tsp-what-is-its-relevance-as-a-prognostic-marker-for-neurologic-disease
#7
Marina Lobato Martins, Jacqueline Cronemberger Guimarães, João Gabriel Ribas, Luiz Cláudio Ferreira Romanelli, Anna Bárbara de Freitas Carneiro-Proietti
HTLV-1 proviral load (pvl) is an important risk marker for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its value as prognostic marker is not well defined. Long-term prospective cohort studies are necessary to clarify this question. Here, we analyzed HTLV-1 pvl in the peripheral blood of 82 asymptomatic carriers (AC; 351 samples), 12 HAM/TSP patients (HAM; 46 samples), and six incident cases of HAM/TSP (iHAM), with serial samples collected before (n = 10) and after (n = 20) the disease onset...
September 27, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27603042/the-fas-670-aa-genotype-is-associated-with-high-proviral-load-in-peruvian-ham-tsp-patients
#8
Jason Rosado, Sandra Morales, Giovanni Lopez, Daniel Clark, Kristien Verdonck, Eduardo Gotuzzo, Guy Van Camp, Michael Talledo
BACKGROUND: Human T-lymphotropic virus 1 (HTLV-1) is the etiologic agent of the HTLV-I-Associated Myelopathy-Tropical Spastic Paraparesis (HAM/TSP). Apoptosis is a mechanism of defense elicited by many triggers, including cross-linking of the FAS receptor expressed in viruses-infected cells, and the ligand FASL presented by T-cytotoxic cells. Since HAM/TSP has been associated with high levels of proviral load (PVL), we hypothesized that certain genotypes of single-nucleotide polymorphisms (SNPs) associated with a decreased protein expression of FAS and FASL could be risk factors for this disease...
September 7, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27553711/analyses-of-htlv-1-sequences-suggest-interaction-between-orf-i-mutations-and-ham-tsp-outcome
#9
Fernanda Khouri Barreto, Ricardo Khouri, Filipe Ferreira de Almeida Rego, Luciane Amorim Santos, Maria Fernanda de Castro-Amarante, Izabela Bialuk, Cynthia A Pise-Masison, Bernardo Galvão-Castro, Antoine Gessain, Steven Jacobson, Genoveffa Franchini, Luiz Carlos Alcantara
The region known as pX in the 3' end of the human T-cell lymphotropic virus type 1 (HTLV-1) genome contains four overlapping open reading frames (ORF) that encode regulatory proteins. HTLV-1 ORF-I produces the protein p12 and its cleavage product p8. The functions of these proteins have been linked to immune evasion and viral infectivity and persistence. It is known that the HTLV-1 infection does not necessarily imply the development of pathological processes and here we evaluated whether natural mutations in HTLV-1 ORF-I can influence the proviral load and clinical manifestation of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
November 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27542993/htlv-1-induces-a-th1-like-state-in-cd4-ccr4-t-cells-that-produces-an-inflammatory-positive-feedback-loop-via-astrocytes-in-ham-tsp
#10
Yoshihisa Yamano, Ariella Coler-Reilly
The main feature of Human T-lymphotropic virus type I (HTLV-1) -associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis is a virus-induced hyperactive immune response that produces chronic inflammation in the central nervous system (CNS), but the mechanism by which HTLV-1 deregulates the immune response is unknown. We recently reported a high frequency of HTLV-1-infected CCR4(+) cells, including regulatory T cells. We showed that HTLV-1 induces a Th1-like state in these CCR4(+) cells via T-bet expression...
August 12, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27519553/development-of-neurologic-diseases-in-a-patient-with-primate-t-lymphotropic-virus-type-1-ptlv-1
#11
Yoshimi Enose-Akahata, Breanna Caruso, Benjamin Haner, Emily Charlip, Govind Nair, Raya Massoud, Bridgette J Billioux, Joan Ohayon, William M Switzer, Steven Jacobson
BACKGROUND: Virus transmission from various wild and domestic animals contributes to an increased risk of emerging infectious diseases in human populations. HTLV-1 is a human retrovirus associated with acute T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 originated from ancient zoonotic transmission from nonhuman primates, although cases of zoonotic infections continue to occur. Similar to HTLV-1, the simian counterpart, STLV-1, causes chronic infection and leukemia and lymphoma in naturally infected monkeys, and combined are called primate T-lymphotropic viruses (PTLV-1)...
2016: Retrovirology
https://www.readbyqxmd.com/read/27449854/autoantibodies-to-heterogeneous-nuclear-ribonuclear-protein-a1-hnrnpa1-cause-altered-ribostasis-and-neurodegeneration-the-legacy-of-ham-tsp-as-a-model-of-progressive-multiple-sclerosis
#12
Michael C Levin, Sangmin Lee, Lidia A Gardner, Yoojin Shin, Joshua N Douglas, Hannah Salapa
Several years following its discovery in 1980, infection with human T-lymphotropic virus type 1 (HTLV-1) was shown to cause HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a disease biologically similar to progressive forms of multiple sclerosis (MS). In this manuscript, we review some of the clinical, pathological, and immunological similarities between HAM/TSP and MS with an emphasis on how autoantibodies to an RNA binding protein, heterogeneous nuclear ribonuclear protein A1 (hnRNP A1), might contribute to neurodegeneration in immune mediated diseases of the central nervous system...
July 17, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27449667/hla-g-3-untranslated-region-polymorphisms-are-associated-with-htlv-1-infection-proviral-load-and-htlv-associated-myelopathy-tropical-spastic-paraparesis-development
#13
Daiani Cristina Cilião Alves, Rodrigo Haddad, Maurício Cristiano Rocha-Júnior, Virgínia Mara de Deus Wagatsuma, Gustavo Martelli-Palomino, Adriana Aparecida Marques, Osvaldo Massaiti Takayanagui, Dimas Tadeu Covas, Simone Kashima, Eduardo Antônio Donadi
Most human T-lymphotropic virus type 1 (HTLV-1)-infected patients remain asymptomatic throughout life. The factors associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) development have not been fully elucidated; immunological and genetic factors may be involved. The association of 14 bp INS/DEL HLA-G polymorphism with HTLV-1 infection susceptibility has been reported previously. Here, other polymorphic sites at the HLA-G 3'-UTR (14-bp D/I, +3003C/T, +3010C/G, +3027A/C, +3035C/T, +3142C/G, +3187A/G and +3196C/G) were evaluated in 37 HTLV-1-infected individuals exhibiting HAM/TSP, 45 HTLV-1 asymptomatic carriers (HAC) and 153 uninfected individuals, followed up at University Hospital of the Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil...
October 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27382445/median-nerve-somatosensory-evoked-potential-in-htlv-i-associated-myelopathy
#14
Reza Boostani, Ali Poorzahed, Zahra Ahmadi, Ali Mellat
INTRODUCTION: HTLV-I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a progressive Myelopathy that mainly involves the corticospinal tract. Despite pronounced involvement of the lower limbs, patients also have abnormalities in their upper limbs. So, we studied somatosensory-evoked potentials (SSEPs) of the median nerve in HAM/TSP patients to determine the extent of the involvement of the pathway of the central nervous system, especially the cervical spinal cord. METHODS: In this cross sectional study, 48 patients with HAM/TSP who were referred to Qaem Hospital in Mashhad from October 2010 to October 2011 were evaluated for various indices, including SSEPs of the median nerve for N9, N11, N13, and N20 waveforms and also N11-13 and N13-20 Inter Peak Latency (IPL), severity of disease (based on Osama criteria), disease duration (less or more than 2 years), age, and gender...
May 2016: Electronic Physician
https://www.readbyqxmd.com/read/27322309/transcriptional-and-epigenetic-regulatory-mechanisms-affecting-htlv-1-provirus
#15
REVIEW
Paola Miyazato, Misaki Matsuo, Hiroo Katsuya, Yorifumi Satou
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus associated with human diseases, such as adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/Tropic spastic paraparesis (HAM/TSP). As a retrovirus, its life cycle includes a step where HTLV-1 is integrated into the host genomic DNA and forms proviral DNA. In the chronic phase of the infection, HTLV‑1 is known to proliferate as a provirus via the mitotic division of the infected host cells. There are generally tens of thousands of infected clones within an infected individual...
2016: Viruses
https://www.readbyqxmd.com/read/27320936/developing-novel-treatments-for-htlv-1-associated-myelopathy-ham-by-investigating-molecular-pathomechanisms
#16
Natsumi Araya, Tomoo Sato, Ariella Coler-Reilly, Naoko Yagishita, Yoshihisa Yamano
  A small percentage of those infected with human T-lymphotropic virus type 1 (HTLV-1) develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a debilitating neurodegenerative disease. This disease impacts essential bodily functions, and since currently available treatments are considered to be poorly effective, there is a dire need to develop a truly effective treatment to suppress disease progression. Recently, the authors and others have determined that HTLV-1 in HAM/TSP patients primarily infects T cells expressing the chemokine receptor CCR4...
2016: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27268291/htlv-1-associated-myelopathy-in-a-solid-organ-transplant-recipient
#17
Maria Jose Montesdeoca Andrade, Edgar Patricio Correa Diaz, Maria Eugenia Buestán
Human T-cell lymphotropic virus type-1 (HTLV-1) is endemic in Japan, the Caribbean and in South American countries such as Ecuador. This virus is the cause of HTLV-1-associated myelopathy or tropical spastic paraparesis (HAM/TSP), a myelopathy characterised by chronic progressive paraparesis, spasticity and urinary symptoms. We report the case of a 40-year-old man who received a kidney transplant from a living donor and developed HAM/TSP, 24 months after transplant. The diagnosis was confirmed by detection of HTLV-1 in blood and cerebrospinal fluid by the ELISA and Western Blot tests...
June 6, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27225443/nation-wide-epidemiological-study-of-japanese-patients-with-rare-viral-myelopathy-using-novel-registration-system-ham-net
#18
Ariella L G Coler-Reilly, Naoko Yagishita, Hiroko Suzuki, Tomoo Sato, Natsumi Araya, Eisuke Inoue, Ayako Takata, Yoshihisa Yamano
BACKGROUND: At least one million people are infected with human T-lymphotropic virus type 1 (HTLV-1) in Japan, a small percentage of whom develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T-cell leukemia/lymphoma (ATLL). Patients with HAM/TSP suffer from progressively worsening myelopathic symptoms, such as motor disability and bladder dysfunction, and may become wheelchair-bound or even bedridden. METHODS: To learn more about this rare, debilitating disease, we established the national registration system "HAM-net" in March 2012...
2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27117327/absolute-quantification-of-htlv-1-basic-leucine-zipper-factor-hbz-protein-and-its-plasma-antibody-in-htlv-1-infected-individuals-with-different-clinical-status
#19
Yasuo Shiohama, Tadasuke Naito, Toshio Matsuzaki, Reiko Tanaka, Takeaki Tomoyose, Hiroshi Takashima, Takuya Fukushima, Yuetsu Tanaka, Mineki Saito
BACKGROUND: Human T cell leukemia virus type 1 (HTLV-1) basic leucine zipper factor (HBZ), which is encoded by a minus strand mRNA, is thought to play important roles in the development of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, a comprehensive analysis of HBZ, including mRNA and protein expression, humoral immunoreactivity against HBZ, and HTLV-1 proviral load (PVL), in HTLV-1-infected individuals with different clinical status has not been reported previously...
2016: Retrovirology
https://www.readbyqxmd.com/read/27077747/effect-of-pulsed-methylprednisolone-on-pain-in-patients-with-htlv-1-associated-myelopathy
#20
Kevin G Buell, Aiysha Puri, Maria Antonietta Demontis, Charlotte L Short, Adine Adonis, Jana Haddow, Fabiola Martin, Divya Dhasmana, Graham P Taylor
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an immune mediated myelopathy caused by the human T-lymphotropic virus type 1 (HTLV-1). The efficacy of treatments used for patients with HAM/TSP is uncertain. The aim of this study is to document the efficacy of pulsed methylprednisolone in patients with HAM/TSP. Data from an open cohort of 26 patients with HAM/TSP was retrospectively analysed. 1g IV methylprednisolone was infused on three consecutive days. The outcomes were pain, gait, urinary frequency and nocturia, a range of inflammatory markers and HTLV-1 proviral load...
2016: PloS One
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