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https://www.readbyqxmd.com/read/29212212/adamts1-mediated-targeting-of-tsp-1-by-ppar%C3%AE-suppresses-migration-and-invasion-of-breast-cancer-cells
#1
Sun Ah Ham, Taesik Yoo, Won Jin Lee, Jung Seok Hwang, Jinwoo Hur, Kyung Shin Paek, Dae-Seog Lim, Sung Gu Han, Chi-Ho Lee, Han Geuk Seo
Migration and invasion of cancer cells into surrounding tissue is a key stage of cancer metastasis. Here, we show that peroxisome proliferator-activated receptor (PPAR) δ regulates migration and invasion of human breast cancer cells via thrombospondin-1 (TSP-1) and its degrading protease, a disintegrin and metalloprotease domains with thrombospondin motifs 1 (ADAMTS1). Activation of PPARδ by GW501516, a specific ligand for PPARδ, led to marked inhibition in the cell migration and TSP-1 expression of breast cancer...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29202792/the-cc-chemokine-ligand-ccl-1-upregulated-by-the-viral-transactivator-tax-can-be-downregulated-by-minocycline-possible-implications-for-long-term-treatment-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis
#2
Mineki Saito, Hiroe Sejima, Tadasuke Naito, Hiroshi Ushirogawa, Toshio Matsuzaki, Eiji Matsuura, Yuetsu Tanaka, Tatsufumi Nakamura, Hiroshi Takashima
BACKGROUND: Chemokine (C-C motif) ligand 1 (CCL1) is produced by activated monocytes/ macrophages and T-lymphocytes, and acts as a potent attractant for Th2 cells and a subset of T-regulatory (Treg) cells. Previous reports have indicated that CCL1 is overexpressed in adult T-cell leukemia cells, mediating an autocrine anti-apoptotic loop. Because CCL1 is also known as a potent chemoattractant that plays a major role in inflammatory processes, we investigated the role of CCL1 in the pathogenesis of human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
December 4, 2017: Virology Journal
https://www.readbyqxmd.com/read/29186194/human-t-cell-leukemia-virus-type-1-infects-multiple-lineage-hematopoietic-cells-in-vivo
#3
Rie Furuta, Jun-Ichirou Yasunaga, Michi Miura, Kenji Sugata, Akatsuki Saito, Hirofumi Akari, Takaharu Ueno, Norihiro Takenouchi, Jun-Ichi Fujisawa, Ki-Ryang Koh, Yusuke Higuchi, Mohamed Mahgoub, Masakazu Shimizu, Fumihiko Matsuda, Anat Melamed, Charles R Bangham, Masao Matsuoka
Human T-cell leukemia virus type 1 (HTLV-1) infects mainly CD4+CCR4+ effector/memory T cells in vivo. However, it remains unknown whether HTLV-1 preferentially infects these T cells or this virus converts infected precursor cells to specialized T cells. Expression of viral genes in vivo is critical to study viral replication and proliferation of infected cells. Therefore, we first analyzed viral gene expression in non-human primates naturally infected with simian T-cell leukemia virus type 1 (STLV-1), whose virological attributes closely resemble those of HTLV-1...
November 29, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29129607/polymorphisms-in-hla-c-and-kir-alleles-are-not-associated-with-ham-tsp-risk-in-htlv-1-infected-subjects
#4
Tatiane Assone, Fernanda M Malta, Sonia Bakkour, Leilani Montalvo, Arthur M Paiva, Jerusa Smid, Augusto César Penalva de Oliveira, Fernanda de Toledo Gonçalves, Olinda do Carmo Luiz, Luiz Augusto M Fonseca, Philip J Norris, Jorge Casseb
INTRODUCTION: Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association of immune related genetic polymorphisms with viral and immunological markers. METHODS: 247 HTLV-1-infected volunteers, drawn from a larger group of HTLV-infected subjects followed at the Institute of Infectious Diseases "Emilio Ribas" (IIER) for up to 19 years, participated in this study, which ran from June 2011 to July 2016...
November 10, 2017: Virus Research
https://www.readbyqxmd.com/read/29095831/ct-chest-and-pulmonary-functional-changes-in-patients-with-htlv-associated-myelopathy-in-the-eastern-brazilian-amazon
#5
Luiz Fábio Magno Falcão, Aline Semblano Carreira Falcão, Rita Catarina Medeiros Sousa, Waldônio de Brito Vieira, Robson Tadachi Moraes de Oliveira, Valéria Marques Ferreira Normando, George Alberto da Silva Dias, Marcio Clementino de Souza Santos, Rodrigo Santiago Barbosa Rocha, Gilberto Toshimitsu Yoshikawa, Roberta Vilela Lopes Koyama, Satomi Fujihara, Víctor Augusto Cavaleiro Corrêa, Hellen Thais Fuzii, Juarez Aantônio Simões Quaresma
The aim of this study was to compare computed tomography (CT) scans of chest and lung function among patients with Human T-Lymphotropic Virus Type 1 (HTLV) with and without HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this cross-sectional study performed between January 2013 and June 2016, we included 48 patients with HAM/TSP (19 women and 11 men) and without HAM/TSP (12 women and 6 men). We compared CT findings and lung functions of these groups. Patients who had HAM/TSP had abnormal CT findings (P = 0...
2017: PloS One
https://www.readbyqxmd.com/read/29024167/imaging-spinal-cord-atrophy-in-progressive-myelopathies-htlv-i-associated-neurological-disease-ham-tsp-and-multiple-sclerosis-ms
#6
Shila Azodi, Govind Nair, Yoshimi Enose-Akahata, Emily Charlip, Ashley Vellucci, Irene Cortese, Jenifer Dwyer, B Jeanne Billioux, Chevaz Thomas, Joan Ohayon, Daniel S Reich, Steven Jacobson
OBJECTIVE: Previous work measures spinal cord thinning in chronic progressive myelopathies, including human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS). Quantitative measurements of spinal cord atrophy are important in fully characterizing these and other spinal cord diseases. We aimed to investigate patterns of spinal cord atrophy and correlations with clinical markers. METHODS: Spinal cord cross-sectional area was measured in individuals (24 healthy controls [HCs], 17 asymptomatic carriers of HTLV-1 (AC), 47 HAM/TSP, 74 relapsing-remitting MS [RRMS], 17 secondary progressive MS [SPMS], and 40 primary progressive MS [PPMS]) from C1 to T10...
November 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28991665/spinal-cord-anteroposterior-atrophy-in-ham-tsp-magnetic-resonance-imaging-and-neuropathological-analyses
#7
Akitoshi Taniguchi, Hitoshi Mochizuki, Atsushi Yamashita, Kazutaka Shiomi, Yujiro Asada, Masamitsu Nakazato
To evaluate the spinal cord atrophy that occurs in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we conducted magnetic resonance imaging (MRI) and pathological analyses. In the MRI study, 15 patients with HAM/TSP and 20 age-matched normal control subjects were enrolled. Anteroposterior and transverse distances and cross-sectional areas were measured and calculated at the C2, C4, C6, T2, and T6 vertebral levels. In the pathological study, spinal cord autopsy specimens were compared between a HAM/TSP case and an adult T cell leukemia/lymphoma case...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28985098/retinal-nerve-fiber-layer-thickness-in-human-t-cell-lymphotropic-virus-type-1-patients
#8
Harold Merle, Rabih Hage, Séverine Jeannin, Philippe Cabre, Stéphane Olindo
PURPOSE: To determine whether there is an optic neuropathy (ON) in patients with human T-cell lymphotropic virus type 1 (HTLV-1) infection. METHODS: We included HTLV-1 asymptomatic carriers (a.c.HTLV-1) and tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) patients between January 1st, 2014 and March 31st, 2015. All patients had complete eye examination. The visual acuity (VA) and retinal nerve fiber layer (RNFL) thickness were measured and compared to age- and sex-matched control groups including patients seen in our refraction clinic with no previous medical or surgical history...
October 6, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28954118/case-for-diagnosis-infective-dermatitis-associated-with-htlv-1-differential-diagnosis-of-atopic-dermatitis
#9
Lorena Maria Lima de Oliveira, Marcos Vilela de Souza, Antonio Carlos Martins Guedes, Marcelo Grossi Araújo
Infective dermatitis associated with HTLV-1 (IDH) is the main cutaneous marker of HTLV-1 infection. This disease occurs primarily in children and should be differentiated from other eczemas, especially from atopic dermatitis. The largest series of IDH are from Jamaica and Brazil. There are an estimated 15 to 20 million infected people in the world, and Brazil is one of the endemic regions. Studies suggest that IDH in children may be a marker for the development of T-cell leukemia/lymphoma (ATL) or myelopathy associated with HTLV-1/tropical spastic paraparesis (HAM / TSP) in adulthood...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28910419/il-10-mediated-signals-act-as-a-switch-for-lymphoproliferation-in-human-t-cell-leukemia-virus-type-1-infection-by-activating-the-stat3-and-irf4-pathways
#10
Leila Sawada, Yoshiko Nagano, Atsuhiko Hasegawa, Hikari Kanai, Kai Nogami, Sayaka Ito, Tomoo Sato, Yoshihisa Yamano, Yuetsu Tanaka, Takao Masuda, Mari Kannagi
Human T-cell leukemia virus type-1 (HTLV-1) causes two distinct diseases, adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Since there are no disease-specific differences among HTLV-1 strains, the etiological mechanisms separating these respective lymphoproliferative and inflammatory diseases are not well understood. In this study, by using IL-2-dependent HTLV-1-infected T-cell lines (ILTs) established from patients with ATL and HAM/TSP, we demonstrate that the anti-inflammatory cytokine IL-10 and its downstream signals potentially act as a switch for proliferation in HTLV-1-infected cells...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28888743/htlv-1-infected-thymic-epithelial-cells-convey-the-virus-to-cd4-t-lymphocytes
#11
Luciana Rodrigues Carvalho Barros, Leandra Linhares-Lacerda, Klaysa Moreira-Ramos, Marcelo Ribeiro-Alves, Maria Cristina Machado Motta, Dumith Chequer Bou-Habib, Wilson Savino
The human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4(+)T cells are the main target of HTLV-1, but other cell types are known to be infected, including immature lymphocytes. Developing T cells undergo differentiation in the thymus, through migration and interaction with the thymic microenvironment, in particular with thymic epithelial cells (TEC) the major component of this three dimensional meshwork of non-lymphoid cells...
August 14, 2017: Immunobiology
https://www.readbyqxmd.com/read/28876483/htlv-1-intrafamilial-transmission-among-japanese-immigrants-in-brazil
#12
Larissa M Bandeira, Silvia N O Uehara, Marco A M Puga, Grazielli R Rezende, Ana C P Vicente, João A Domingos, Bárbara V do Lago, Christian Niel, Ana R C Motta-Castro
Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The aim of this study was to investigate the intrafamilial transmission of HTLV-1 among Japanese immigrants and their descendants living in a non-endemic area of central Brazil. Six families were investigated. Thirty-seven relatives of the six index cases were tested by ELISA for the presence of anti-HTLV antibodies, and the positive cases were confirmed by Western blot...
September 6, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28771137/the-duffy-null-genotype-is-associated-with-a-lower-level-of-ccl2-leukocytes-and-neutrophil-count-but-not-with-the-clinical-outcome-of-htlv-1-infection
#13
Maria Clara Fernandes da Silva-Malta, Camila Campos Sales, Jacqueline Cronemberger Guimarães, Poliane de Cássia Gonçalves, Daniel Gonçalves Chaves, Hadassa Campos Santos, Alexandre da Costa Pereira, João Gabriel Ribas, Anna Bárbara de Freitas Carneiro-Proietti, Marina Lobato Martins
PURPOSE: Chemokines are important in the immune response against viral infections, and may play a role in human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis. Polymorphisms in the Duffy antigen receptor for chemokines (DARC), such as rs12075 (A>G; FY*B>FY*A) and rs281477 (-46T>C; GATA-1 box) may influence circulating concentrations of proinflammatory chemokines. We investigate whether Duffy genotypes influence the HTLV-1 proviral load (PVL) level, HTLV-1 infection outcome and chemokine concentrations in HTLV-1 asymptomatic carriers (AC=162), HAM/TSP patients (HAM=135) and seronegative individuals (SN=71)...
August 4, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28716148/prevalence-of-plasma-autoantibody-against-cancer-testis-antigen-ny-eso-1-in-htlv-1-infected-individuals-with-different-clinical-status
#14
Yasuo Shiohama, Tadasuke Naito, Toshio Matsuzaki, Reiko Tanaka, Takeaki Tomoyose, Hiroshi Takashima, Takuya Fukushima, Yuetsu Tanaka, Mineki Saito
BACKGROUND: Detection of specific immune responses against cancer/testis antigen NY-ESO-1 was recently reported in patients with adult T-cell leukemia/lymphoma (ATL) and human T-cell leukemia virus type 1 (HTLV-1)-infected asymptomatic carriers (ACs). However, the relationship of the responses with the HTLV-1 proviral load (PVL) and the levels of viral gene expression remain unclear. FINDINGS: We measured plasma levels of autoantibodies to NY-ESO-1 immunogenic tumor antigen in HTLV-1-infected individuals with different clinical status, and in healthy controls...
July 17, 2017: Virology Journal
https://www.readbyqxmd.com/read/28689168/systemic-diseases-in-patients-with-htlv-1-associated-uveitis
#15
Kumiko Nakao, Noriko Abematsu, Taiji Sakamoto
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) carriers may develop severe systemic diseases, such as adult T cell leukaemia (ATL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This study aims to investigate systemic diseases of HTLV-1 carriers who had developed HTLV-1-associated uveitis (HAU). METHODS: We investigated the occurrence of systemic diseases in 200 patients with HAU by performing a retrospective investigation of their medical records and examining the results of a postal survey...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28651832/htlv-1-infection-in-reunion
#16
G Hoarau, B A Gaüzère, H Renard, P Aubry
OBJECTIVES: Although regularly looked for in blood donors, HTLV infections are very rare in Reunion. We aimed to describe HTLV infections locally. PATIENTS AND METHODS: HTLV infections were identified from the database of the Reunion University Hospital administrative database (PMSI) between 2000 and 2016. Diagnosis was performed with HTLV 1/2 enzyme immunoassay test and confirmed by Western blot. RESULTS: We reported three asymptomatic and four symptomatic HTLV infections, including two tropical spastic paraparesis/HTLV-1 associated myelopathies (TSP/HAM) and two adult T-cell leukemia/lymphoma (ATLL), diagnosed between 2000 and 2016...
June 23, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28648091/mediators-go-together-high-production-of-cxcl9-cxcl10-ifn-%C3%AE-and-tnf-%C3%AE-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis
#17
Heytor Victor Pereira da Costa Neco, Vanessa Gabryelle da Silva Teixeira, Ana Carolina Lemos da Trindade, Paula Machado Ribeiro Magalhães, Virgínia Maria Barros de Lorena, Lúcio Roberto Cançado Castellano, Joelma Rodrigues de Souza, Luydson Richardson Vasconcelos, Patrícia Muniz Mendes Freire de Moura, Clarice Neuenschwander Lins de Morais
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic demyelinating and disabling syndrome caused by human T lymphotropic virus 1 (HTLV-1). Although the pathogenic mechanisms that lead to HAM/TSP outcome have not been elucidated, genetic and immunological factors may be involved in the myelopathy occurrence. This study aimed to compare cytokines, chemokines, and nitric oxide (NO) levels in asymptomatic and HAM/TSP HTLV-1-infected patients. The study group consisted of 21 HAM/TSP and 48 asymptomatic HTLV-1 patients...
November 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28615198/polymorphic-nature-of-human-t-cell-leukemia-virus-type-1-particle-cores-as-revealed-through-characterization-of-a-chronically-infected-cell-line
#18
Morgan E Meissner, Luiza M Mendonça, Wei Zhang, Louis M Mansky
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 cell-to-cell transmission is dependent on the release of infectious virus particles into the virological synapse. The HTLV-1 particle structure is still poorly understood, and previous studies analyzed viruses produced by transformed lymphocytic cell lines chronically infected with HTLV-1, particularly the MT-2 cell line, which harbors truncated proviruses and expresses aberrant forms of the Gag protein...
August 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28608127/downregulation-of-histone-methyltransferase-ehmt2-in-cd4-t-cells-may-protect-htlv-1-infected-individuals-against-ham-tsp-development
#19
Camila Schoueri Colaço, Adriano Reis de Matos, Martha Silva Estrêla, Maurício Cristiano Rocha-Júnior, Kátia Kaori Otaguiri, Evandra Strazza Rodrigues, Osvaldo Massaiti Takayanagui, Dimas Tadeu Covas, Simone Kashima, Fabio Pittella Silva, Rodrigo Haddad
Approximately 5% of human T-cell leukemia virus type 1 (HTLV-1)-infected individuals will develop one of the HTLV-1-related diseases, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T-cell leukemia. However, the mechanisms responsible for the appearance of symptoms have not been fully clarified. It is believed that viral factors, host genetic and epigenetic mechanisms are implicated in this process. Studies have shown the involvement of histone methyltransferases in retrovirus infection, but no study observed their expression in HTLV-1-infected patients...
June 12, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28596939/undifferentiated-pleomorphic-sarcoma-and-the-importance-of-considering-the-oncogenic-and-immune-suppressant-role-of-the-human-t-cell-lymphotropic-virus-type-1-a-case-report
#20
Sergio Lupo, Carolina Berini, Camila Cánepa, Eduardo Santini Araujo, Mirna Biglione
INTRODUCTION: Soft-tissue sarcomas account for 0.7% of all malignant tumors, with an incidence rate of 3 per 100,000 persons/year. The undifferentiated pleomorphic sarcoma (UPS) with giant cells, a high grade tumor of soft tissue, is very unusual, especially in young adults before the age of 40. Human T-cell lymphotropic virus type 1 (HTLV-1) is a human retrovirus, classified as group 1 human carcinogens by The International Agency for Research on Cancer, that causes an aggressive malignancy known as adult T-cell lymphoma/leukemia and a progressive chronic inflammatory neurological disease named HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
2017: Frontiers in Oncology
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