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https://www.readbyqxmd.com/read/28293169/brain-metabolism-changes-in-patients-infected-with-htlv-1
#1
Manuel Schütze, Luiz C F Romanelli, Daniela V Rosa, Anna B F Carneiro-Proietti, Rodrigo Nicolato, Marco A Romano-Silva, Michael Brammer, Débora M de Miranda
The Human T-cell leukemia virus type-I (HTLV-1) is the causal agent of HTLV-associated myelopathy/Tropical Spastic Paraparesis (HAM/TSP). HAM/TSP is the result of demyelination and cell death in the spinal cord and disruption of the blood-brain barrier (BBB), mediated by a virus-induced inflammatory response. In this study, we applied Positron Emission Tomography with 18F-fluordeoxyglucose (18F-FDG PET) to evaluate brain metabolism in a group of 47 patients infected with HTLV-1, and 18 healthy controls. Patients were divided into three groups according to their neurological symptoms...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28282508/cardiovascular-risk-profile-in-patients-with-myelopathy-associated-with-htlv-1
#2
Fabio Luís Silva do Prado, Renata Prado de Fuccio Oliveira, Ana Marice Teixeira Ladeia
HAM/TSP (HTLV-1-associated myelopathy/tropical spastic paraparesis) is a slowly progressive disease, characterized by a chronic spastic paraparesis. It is not known if the disease carries an independent risk for cardiovascular disease. The objective of this study was to evaluate the cardiovascular risk profile related to HAM/TSP and compare it with the general population. METHODS: This was a cross-sectional study, with a control group. HAM/TSP patients were evaluated using cardiovascular risk scores (ASCVD RISK, SCORE and Framingham) and inflammatory markers (ultrasensitive CRP and IL-6), and compared with a control group of healthy individuals...
March 7, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28263674/human-t-cell-leukemia-virus-type-1-and-eye-diseases
#3
Yukiko Terada, Koju Kamoi, Takashi Komizo, Kazunori Miyata, Manabu Mochizuki
Human T cell leukemia virus type 1, also known as human T lymphotropic virus type 1 (HTLV-1), is a retrovirus that encodes a reverse transcriptase, which translates viral RNA into a DNA provirus that is integrated into the host genome. The virus was found to be a causative agent of adult T cell leukemia/lymphoma (ATL) in the early 1980s, and was also found to cause the neurological disorder tropical spastic paraparesis (TSP)/HTLV-1-associated myelopathy (HAM) and the inflammatory disorder HTLV-1 uveitis in the mid 1980s and early 1990s, respectively...
March 1, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28261958/rate-of-positive-autoimmune-markers-in-human-t-lymphotropic-virus-type-1-carriers-a-case-control-study-from-iran
#4
Sanaz Ahmadi Ghezeldasht, Mohammad Reza Hedayati-Moghaddam, Meysam Habibi, Farzad Mollahosseini, Houshang Rafatpanah, Rahele Miri, MohammadReza Hatef Fard, Maryam Sahebari
AIM: Human T lymphotropic virus type 1 (HTLV-1) infection with high prevalence in the north-east of Iran, particularly in Mashhad, can lead to adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and a variety of autoimmune diseases. The aim of the study was to examine the presence of autoimmune markers in HTLV carries. METHODS: Serum samples were obtained from blood donors in Mashhad, northeastern Iran. One hundred and five HTLV-1 positive (cases) and 104 age- and sex-matched HTLV-1 negative donors (controls) were assessed for presence of serum autoimmune markers by enzyme-linked immunosorbent assay...
March 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28261198/a-fas-hi-lymphoproliferative-phenotype-reveals-non-apoptotic-fas-signaling-in-htlv-1-associated-neuroinflammation
#5
Soraya Maria Menezes, Fabio E Leal, Tim Dierckx, Ricardo Khouri, Daniele Decanine, Gilvaneia Silva-Santos, Saul V Schnitman, Ramon Kruschewsky, Giovanni López, Carolina Alvarez, Michael Talledo, Eduardo Gotuzzo, Douglas F Nixon, Jurgen Vercauteren, David Brassat, Roland Liblau, Anne Mieke Vandamme, Bernardo Galvão-Castro, Johan Van Weyenbergh
Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since only a minority of infected individuals develops either ATL or the neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A functional FAS -670 polymorphism in an interferon (IFN)-regulated STAT1-binding site has been associated to both ATL and HAM/TSP susceptibility. Fas(hi) T stem cell memory (Tscm) cells have been identified as the hierarchical apex of ATL, but have not been investigated in HAM/TSP...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28212879/flow-cytometric-based-protocols-for-assessing-anti-mt-2-igg1-reactivity-high-dimensional-data-handling-to-define-predictors-for-clinical-follow-up-of-human-t-cell-leukemia-virus-type-1-infection
#6
Jordana Grazziela Coelho-Dos-Reis, Vanessa Peruhype-Magalhães, Marcelo Antônio Pascoal-Xavier, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Ludmila Melo Cardoso, Juan Jonathan-Gonçalves, Ágata Lopes Ribeiro, Ana Lúcia Borges Starling, João Gabriel Ribas, Denise Utsch Gonçalves, Anna Bárbara de Freitas Carneiro-Proietti, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho
The present work provides an innovative methodological approach to assess the anti-HTLV-1 IgG1 reactivity with practical application in clinical laboratory. Serum from non-infected healthy controls (NI) and HTLV-1-infected patients, categorized as asymptomatic (AS), putatively progressing to HTLV-1 associated myelopathy/tropical spastic paraparesis - HAM/TSP (pHAM) or with clinical diagnosis of HAM/TSP (HT) were assayed in two-parallel flow cytometry platforms, referred as: Fix and Fix&Perm protocols. Operating-characteristics analysis indicated that a single pair of attributes ("serum dilution/cut-off") for Fix and Fix&Perm protocols presented excellent performance for the diagnosis of HTLV-1 infection...
February 16, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28206670/altered-expression-of-cxcr3-and-ccr6-and-their-ligands-in-htlv-1-carriers-and-ham-tsp-patients
#7
Houshang Rafatpanah, Mehdi Felegari, Mahmoud Reza Azarpazhooh, Rosita Vakili, Taraneh Rajaei, Ian Hampson, Golmahossein Hassanshahi, Narges Valizadeh, Sina Gerayli, Farajifard Hamid, Shadi Zamanian, Farzad MollaHosseini, Seyed Abdolrahim Rezaee
Recruitment of leukocytes by chemokines and chemokine receptors to CNS plays a crucial role in the induction of inflammatory response in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In the present study, chemokine and chemokine receptors involved in trafficking of lymphocytes to the CNS were measured in HAM/TSP patients, HTLV-1 asymptomatic carriers (ACs), and healthy controls. The PVL, CCR6, and CXCR3 mRNA expression, and CXCL9 and CXCL10 protein levels were measured in all subjects...
February 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28185943/hepatitis-c-virus-and-human-t-cell-lymphotropic-virus-type-1-co-infection-impact-on-liver-disease-virological-markers-and-neurological-outcomes
#8
Otávio M Espíndola, Alexandre G Vizzoni, Elisabeth Lampe, Maria José Andrada-Serpa, Abelardo Q C Araújo, Ana Claudia C Leite
OBJECTIVES: Human T-cell lymphotropic virus type 1 (HTLV-1) infection is associated with neurological abnormalities, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and peripheral neuropathy (PN). Hepatitis C virus (HCV) infection is the leading cause of chronic liver disease worldwide, and causes PN in approximately 9% of patients. Because the interplay between these potentially neuropathogenic viruses in the same individual is still poorly understood, the clinical and laboratory outcomes of co-infected patients were evaluated and compared with those of controls...
February 7, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28178142/treatment-of-rheumatoid-arthritis-with-biologics-may-exacerbate-htlv-1-associated-conditions-a-case-report
#9
Yukiko Terada, Koju Kamoi, Kyoko Ohno-Matsui, Kazunori Miyata, Chinami Yamano, Ariella Coler-Reilly, Yoshihisa Yamano
RATIONALE: There are roughly 5 to 10 million persons infected with human T-lymphotropic virus type 1 (HTLV-1) worldwide, and the safety of treating this population with biologics remains poorly understood. PATIENT CONCERNS AND DIAGNOSIS: An HTLV-1-infected 66-year-old female with HTLV-1 uveitis (HU) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Her HU had been in remission and her HAM/TSP symptoms had been managed effectively with oral steroids for years...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28101786/evaluation-of-t-regulatory-lymphocytes-transcription-factors-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-patients
#10
Sanaz Ahmadi Ghezeldasht, Hamed Sadeghian, Mahmoud Reza Azarpazhooh, Seyyed Ali Akbar Shamsian, Houshang Rafatpanah, Mahmood Mahmoodi, Seyyed Abdolrahim Rezaee
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an aggressive neurological disease. The CD4(+)CD25(+) T cell population plays pivotal roles in the maintenance of immunological tolerance and prevention of such autoimmune diseases. In the current study, proviral load (PVL), factor forkhead box p3 (Foxp3), and glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) gene expression and regulatory T cells (Tregs) counts of 21 HAM/TSP patients and 16 HTLV-1 healthy carriers (ACs) were measured using real-time PCR, TaqMan method, and flow cytometry...
January 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28095504/cytoplasmic-localization-of-htlv-1-hbz-protein-a-biomarker-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp
#11
Marco Baratella, Greta Forlani, Goutham U Raval, Alessandra Tedeschi, Olivier Gout, Antoine Gessain, Giovanna Tosi, Roberto S Accolla
HTLV-1 is the causative agent of a severe form of adult T cell leukemia/Lymphoma (ATL), and of a chronic progressive neuromyelopathy designated HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Two important HTLV-1-encoded proteins, Tax-1 and HBZ, play crucial roles in the generation and maintenance of the oncogenic process. Less information is instead available on the molecular and cellular mechanisms leading to HAM/TSP. More importantly, no single specific biomarker has been described that unambiguously define the status of HAM/TSP...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28040482/schistosoma-antigens-downregulate-cxcl9-production-by-pbmc-of-htlv-1-infected-individuals
#12
Luciane Mota Lima, Luciana Santos Cardoso, Silvane Braga Santos, Ricardo Riccio Oliveira, Sérgio Costa Oliveira, Alfredo Miranda Góes, Alex Loukas, Maria Ilma Araujo
HTLV-1 is the causal agent of Adult T cell Leukemia/lymphoma (ATLL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). The immune response to HTLV-1-infection is polarized to the Th1-type, and the presence of CXCL9/CXCL10 chemokines may lead to an increase in the recruitment of pro-inflammatory molecules in spinal cord tissue, contributing to the damage observed in the development of HAM/TSP. It has been observed that in chronic helminth-infections, such as schistosomiasis, there is a deviation toward the Th2/regulatory immune response...
March 2017: Acta Tropica
https://www.readbyqxmd.com/read/28011062/factors-associated-with-pain-in-individuals-infected-by-human-t-cell-lymphotropic-virus-type-1-htlv-1
#13
Dislene N Dos Santos, Kionna O B Santos, Alaí B Paixão, Rosana Cristina P de Andrade, Davi T Costa, Daniel L S-Martin, Katia N Sá, Abrahão F Baptista
INTRODUCTION: Despite the high prevalence of chronic pain in individuals infected with HTLV-1, predictive and protective factors for its development are still unclear. OBJECTIVE: To identify factors associated with chronic pain in individuals with HTLV-1. METHODS: This cross-sectional study was conducted in a reference center for treatment of patients infected with HTLV-1 in Salvador, Bahia, Brazil. The study included individuals infected with HTLV-1, over 18 years, and excluded those with difficulty to respond the pain protocol...
December 21, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27935065/high-risk-of-heterosexual-transmission-of-human-t-cell-lymphotropic-virus-type-1-infection-in-brazil
#14
Arthur Paiva, Jerusa Smid, Michel E J Haziot, Tatiane Assone, Samara Pinheiro, Luiz A M Fonseca, Augusto C Penalva de Oliveira, Jorge Casseb
Human T-cell lymphotropic virus type 1 is transmitted primarily either through sexual intercourse or from mother to child. The current study investigated sexual transmission and compared the HTLV-1 proviral load between seroconcordant and serodiscordant couples by examining both men and women among the index partners without using subjective criteria to establish the direction of sexual transmission. Between January 2013 and May 2015, 178 HTLV-1-positive patients had spouses, 107 of which had tested partners, thus increasing the initial sample size (46 men and 61 women)...
December 9, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27894665/modulatory-effects-of-curcumin-on-apoptosis-and-cytotoxicity-related-molecules-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-patients
#15
Asadollah Mohammadi, Bahare Fazeli, Marzieh Taheri, Amirhossein Sahebkar, Zohreh Poursina, Vida Vakili, Shadi Zamanian Yazdi, Zahra Keramati, Reza Boostani, Ian Hampson, Houshang Rafatpanah
Apoptosis is a universal cellular defense mechanism against viral infection. Curcumin, an anti-inflammatory phytochemical, induces apoptosis through mitochondrial and receptor-mediated pathways, as well as activation of caspase cascades. Here, we investigated the impact of supplementation with curcumin on the expression of a panel of apoptosis- and cytotoxicity-related genes in patients suffering from HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive demyelinating neuroinflammatory disease caused by HTLV-1 infection...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27887847/role-of-the-htlv-1-viral-factors-in-the-induction-of-apoptosis
#16
REVIEW
Mohammad Karimi, Hamed Mohammadi, Maryam Hemmatzadeh, Asadollah Mohammadi, Houshang Rafatpanah, Behzad Baradaran
Adult T-cell leukemia (ATL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) are the two main diseases that are caused by the HTLV-1 virus. One of the features of HTLV-1 infection is its resistance against programmed cell death, which maintains the survival of cells to oncogenic transformation and underlies the viruses' therapeutic resistance. Two main genes by which the virus develops cancer are Tax and HBZ; playing an essential role in angiogenesis in regulating viral transcription and modulating multiple host factors as well as apoptosis pathways...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27871430/htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-a-comparative-study-to-identify-factors-that-influence-disease-progression
#17
Eiji Matsuura, Satoshi Nozuma, Yuichi Tashiro, Ryuji Kubota, Shuji Izumo, Hiroshi Takashima
OBJECTIVE: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) can progress slowly or rapidly even though a set of symptoms such as spastic paraparesis with pathological reflexes and sweating loss of the lower extremities are commonly observed in patients. Although most of the patients are thought to be infected to HTLV-1 from their mothers by breast feeding, symptoms of HAM/TSP typically manifest in patients later in life (50-60years old in age) and also with a higher prevalence of women to men at a ratio of approximately 3:1...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27845163/the-effect-of-htlv-1-virulence-factors-hbz-tax-proviral-load-hla-class-i-and-plasma-neopterin-on-manifestation-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis
#18
Hanieh Tarokhian, Mahdi Taghadosi, Hushang Rafatpanah, Taraneh Rajaei, Mahmoud Reza Azarpazhooh, Narges Valizadeh, S A Rahim Rezaee
BACKGROUND: Previous studies have suggested debatable roles of Tax and HBZ gene expression in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this study, HTLV-1 and host interactions in the manifestation of HAM/TSP were evaluated. METHODS: A cross-sectional study was conducted on 33 HAM/TSP patients and 38 HTLV-1 asymptomatic carriers (ACs). HTLV-1-Tax, HBZ gene expression, and proviral load (PVL) were assessed using the quantitative real-time PCR (TaqMan), host plasma neopterin level, and HLA-I, and the clinical manifestation were evaluated...
January 15, 2017: Virus Research
https://www.readbyqxmd.com/read/27787900/evaluation-of-htlv-1-hbz-and-proviral-load-together-with-host-ifn-%C3%AE-3-in-pathogenesis-of-ham-tsp
#19
Sayed Hamid Reza Mozhgani, Najmeh Jaberi, Seyyed Abdolrahim Rezaee, Reza Bustani, Seyyed Mohammad Jazayeri, Mohammad Mahdi Akbarian, Saeideh Milani, Hanieh Tarokhian, Mehdi Norouzi
Human T-cell lymphotropic virus 1 (HTLV-1) is associated with two progressive diseases: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia/lymphoma (ATLL). Although HTLV-1 proviral load (PVL) has been introduced as a risk factor for these diseases' progression, it is not sufficient on its own to yield an accurate estimation of the outcome of the infection. In the present study, PVL and HTLV-1 basic leucine zipper factor (HBZ) expression level as viral factors, and IFN λ3 as a host factor, were evaluated in HAM/TSP patients and HTLV-1 asymptomatic carriers (ACs)...
October 27, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27769524/dynamic-acquisition-of-htlv-1-tax-protein-by-mononuclear-phagocytes-role-in-neurologic-disease
#20
Eiji Matsuura, Yoshimi Enose-Akahata, Karen Yao, Unsong Oh, Yuetsu Tanaka, Hiroshi Takashima, Steven Jacobson
Pathology of HTLV-1 associated myelopathy/Tropical spastic paraparesis (HAM/TSP) is believed to be the result of "bystander damage" involving effector CD8 (+) T lymphocytes (CTLs) killing of virus infected cells. But the specific cellular events leading up to tissue injury are still unclear. Here, we developed the Microscopy Imaging of Cytotoxic T lymphocyte assay with Fluorescence emission (MI-CaFé), an optimized visualization analysis to explore the interactions between CTLs and virus infected or viral antigen presenting target cells...
March 15, 2017: Journal of Neuroimmunology
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