Bin Liu, Ihtisham Bukhari, Fazhan Li, Feifei Ren, Ihtisham Bukhari, Xue Xia, Baitong Hu, Haipeng Liu, Thomas F Meyer, Barry J Marshall, Alfred Tay, Yuming Fu, Wanqing Wu, Youcai Tang, Yang Mi, Pengyuan Zheng
INTRODUCTION: Helicobacter pylori (H. pylori) infection has been associated with gastric carcinogenesis. However, the precise involvement of LRP8, the low-density lipoprotein receptor-related protein 8, in H. pylori pathogenesis and gastric cancer (GC) remains poorly understood. OBJECTIVES: To investigate the potential roles of LRP8 in H. pylori infection and gastric carcinogenesis. METHODS: Three-dimensional human-derived gastric organoids (hGO) and gastric cancer organoids (hGCO) were synthesized from the tissues obtained from human donors...
April 10, 2024: Journal of Advanced Research