keyword
https://read.qxmd.com/read/38520736/healthy-lifestyle-is-a-protective-factor-from-moderate-and-severe-relapses-and-steroid-use-in-inflammatory-bowel-disease-a-prospective-cohort-study
#1
JOURNAL ARTICLE
Sandra García-Mateo, Samuel Jesús Martínez-Domínguez, Carla Jerusalén Gargallo-Puyuelo, Beatriz Gallego, Erika Alfambra, María Escuin, Sergio García-Mateo, Julia López, Fernando Gomollón
BACKGROUND: A healthy lifestyle, including good adherence to a Mediterranean diet (MD) and regular physical exercise, may be an important factor during the course of inflammatory bowel disease (IBD). Our aim is to determine whether adherence to MD, physical activity, and the combination of both can impact on IBD course. METHODS: This prospective cohort study includes 693 IBD outpatients who were in remission with a median follow-up time of 27 months (interquartile range 22-29 months)...
March 23, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38516478/the-role-of-gut-microbiome-in-the-pathogenesis-and-the-treatment-of-inflammatory-bowel-diseases
#2
REVIEW
Andrea Vidal-Gallardo, Juan E Méndez Benítez, Leticia Flores Rios, Luis F Ochoa Meza, Rodrigo A Mata Pérez, Edgar Martínez Romero, Andres M Vargas Beltran, Jose L Beltran Hernandez, Douglas Banegas, Brenda Perez, Marily Martinez Ramirez
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is a chronic condition characterized by inflammation of the gastrointestinal tract. Its exact cause is unknown, but it's thought to result from a dysregulated immune response influenced by various factors, including changes in the intestinal microbiota, diet, lifestyle, and genetics. The gut microbiome, consisting of diverse microorganisms, plays a crucial role in maintaining physiological balance, with its disruption leading to inflammatory responses typical of IBD...
February 2024: Curēus
https://read.qxmd.com/read/38505875/dietary-therapies-for-adult-and-pediatric-inflammatory-bowel-disease
#3
REVIEW
Jessica Deas, Neha D Shah, Gauree G Konijeti, Abigail Lundin, Olivia Lanser, Pooja Magavi, Sabina Ali
Diet is an environmental exposure implicated in the development of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). Dietary therapy is also a tool for management of these conditions. Nutrition therapy for IBD has been shown to reduce intestinal inflammation, promote healing, and alleviate symptoms, as well as improve patients' nutrition status. Although the mechanisms of action of most nutrition therapies for IBD are not well understood, the diets are theorized to eliminate triggers for gut dysbiosis and mucosal immune dysfunction associated with the typical Western diet...
March 20, 2024: Nutrition in Clinical Practice
https://read.qxmd.com/read/38491963/jpen-journal-club-83-selecting-trials-to-include-in-a-systematic-review
#4
JOURNAL ARTICLE
Ronald L Koretz
No abstract text is available yet for this article.
March 16, 2024: JPEN. Journal of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/38474831/heat-killed-saccharomyces-boulardii-alleviates-dextran-sulfate-sodium-induced-ulcerative-colitis-by-restoring-the-intestinal-barrier-reducing-inflammation-and-modulating-the-gut-microbiota
#5
JOURNAL ARTICLE
Yuxin Jin, Jingwei Wu, Kunlun Huang, Zhihong Liang
Ulcerative colitis (UC) is a global intestinal disease, and conventional therapeutic drugs often fail to meet the needs of patients. There is an urgent need to find efficient and affordable novel biological therapies. Saccharomyces boulardii has been widely used in food and pharmaceutical research due to its anti-inflammatory properties and gut health benefits. However, there is still a relatively limited comparison and evaluation of different forms of S. boulardii treatment for UC. This study aimed to compare the therapeutic effects of S...
February 29, 2024: Nutrients
https://read.qxmd.com/read/38474712/lactate-protects-intestinal-epithelial-barrier-function-from-dextran-sulfate-sodium-induced-damage-by-gpr81-signaling
#6
JOURNAL ARTICLE
Xiaojing Li, Zhijie Yao, Jin Qian, Hongling Li, Haitao Li
The dysregulation of the intestinal epithelial barrier significantly contributes to the inflammatory progression of ulcerative colitis. Recent studies have indicated that lactate, produced by gut bacteria or derived from fermented foods, plays a key role in modulating inflammation via G-protein-coupled receptor 81 (GPR81). In this study, we aimed to investigate the potential role of GPR81 in the progression of colitis and to assess the impact of lactate/GPR81 signaling on intestinal epithelial barrier function...
February 21, 2024: Nutrients
https://read.qxmd.com/read/38464345/dietary-magnesium-intake-is-inversely-associated-with-ulcerative-colitis-a-case-control-study
#7
JOURNAL ARTICLE
Omid Sadeghi, Zeinab Khademi, Parvane Saneei, Ammar Hassanzadeh-Keshteli, Hamed Daghaghzadeh, Hamid Tavakkoli, Peyman Adibi, Ahmad Esmaillzadeh
BACKGROUND: Ulcerative colitis (UC) causes long-lasting inflammation and ulcers in the gut. Limited observational data are available linking dietary magnesium intake and UC. In the present study, we aimed to investigate the association between dietary magnesium intake and UC in adults. METHODS: The current population-based case-control study was performed on 109 UC patients and 218 age (±2 years) and sex-matched controls. The diagnosis of UC was made according to the standard criteria by a gastroenterology specialist...
January 2024: Crohn's & colitis 360
https://read.qxmd.com/read/38452029/dietary-interventions-and-supplementation-in-patients-with-an-ileal-pouch-anal-anastomosis-a-systematic-review
#8
JOURNAL ARTICLE
Stephanie Gold, Carrie Levinson, Jean-Frederic Colombel, Laura Manning, Bruce E Sands, Maia Kayal
No abstract text is available yet for this article.
March 7, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38450936/potential-effects-of-nutrition-induced-alteration-of-gut-microbiota-on-inflammatory-bowel-disease-a-review
#9
REVIEW
Qi Bai Tian, Shui Jiao Chen, Li Jun Xiao, Jia Qi Xie, Hong Bo Zhao, Xian Zhang
Inflammatory bowel disease (IBD), mainly comprising ulcerative colitis and Crohn's disease, is a group of gradually progressive diseases bringing significant mental anguish and imposes serious economic burdens. Interplay of genetic, environmental, and immunological factors have been implicated in its pathogenesis. Nutrients, as crucial environmental determinants, mainly encompassing carbohydrates, fats, proteins, and micronutrients, are closely related to the pathogenesis and development of IBD. Nutrition is essential for maintaining the dynamic balance of intestinal eco-environments to ensure intestinal barrier and immune homeostasis, while this balance can be disrupted easily by maladjusted nutrition...
March 7, 2024: Journal of Digestive Diseases
https://read.qxmd.com/read/38449867/diet-derived-circulating-antioxidants-and-risk-of-inflammatory-bowel-disease-a-mendelian-randomization-study-and-meta-analysis
#10
JOURNAL ARTICLE
Menglong Zou, Qiaoli Liang, Wei Zhang, Junyao Liang, Ying Zhu, Yin Xu
BACKGROUND: Previous studies have shown conflicting results regarding the impact of circulating antioxidants on the risk of inflammatory bowel disease (IBD). In this study, our intent was to investigate the causal relationship between circulating antioxidants and IBD using Mendelian randomization (MR). METHODS: Instrumental variables for absolute circulating antioxidants (ascorbate, retinol, lycopene, and β-carotene) and circulating antioxidant metabolites (α-tocopherol, γ-tocopherol, ascorbate, and retinol) were screened from published studies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38420131/chronic-abdominal-pain-in-inflammatory-bowel-disease-a-practical-guide
#11
REVIEW
Samantha Baillie, Christine Norton, Sonia Saxena, Richard Pollok
Pain is common in inflammatory bowel disease (IBD), yet many patients feel their pain is not addressed by healthcare professionals. Listening to a patient's concerns about pain, assessing symptoms and acknowledging the impact these have on daily life remain crucial steps in addressing pain in IBD. While acute pain may be effectively controlled by pain medication, chronic pain is more complex and often pharmacological therapies, particularly opioids, are ineffective. Low-dose tricyclic antidepressants and psychological approaches, including cognitive-behavioural therapy, have shown some promise in offering effective pain management while lifestyle changes such as a trial of low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols diet in those with overlapping irritable bowel syndrome may also reduce pain...
2024: Frontline Gastroenterology
https://read.qxmd.com/read/38409485/a-comprehensive-guide-to-assess-gut-mycobiome-and-its-role-in-pathogenesis-and-treatment-of-inflammatory-bowel-disease
#12
REVIEW
Amit Yadav, Renu Yadav, Vishal Sharma, Usha Dutta
Inflammatory bowel disease (IBD) is an immune mediated chronic inflammatory disorder of gastrointestinal tract, which has underlying multifactorial pathogenic determinants such as environmental factors, susceptibility genes, gut microbial dysbiosis and a dysregulated immune response. Human gut is a frequent inhabitant of complex microbial ecosystem encompassing bacteria, viruses, parasites, fungi and other microorganisms that have an undisputable role in maintaining balanced homeostasis. All of these microbes interact with immune system and affect human gut physiology either directly or indirectly with interaction of each other...
February 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/38363772/impact-of-bread-diet-on-intestinal-dysbiosis-and-irritable-bowel-syndrome-symptoms-in-quiescent-ulcerative-colitis-a-pilot-study
#13
JOURNAL ARTICLE
Aleix Lluansí, Marc Llirós, Robert Carreras-Torres, Anna Bahí, Montserrat Capdevila, Anna Feliu, Laura Vilà-Quintana, Núria Elias-Masiques, Emilio Cueva, Laia Peries, Leyanira Torrealba, Josep Oriol Miquel-Cusachs, Míriam Sàbat, David Busquets, Carmen López, Sílvia Delgado-Aros, Librado Jesús Garcia-Gil, Isidre Elias, Xavier Aldeguer
Gut microbiota may be involved in the presence of irritable bowel syndrome (IBS)-like symptomatology in ulcerative colitis (UC) patients in remission. Bread is an important source of dietary fiber, and a potential prebiotic. To assess the effect of a bread baked using traditional elaboration, in comparison with using modern elaboration procedures, in changing the gut microbiota and relieving IBS-like symptoms in patients with quiescent ulcerative colitis. Thirty-one UC patients in remission with IBS-like symptoms were randomly assigned to a dietary intervention with 200 g/d of either treatment or control bread for 8 weeks...
2024: PloS One
https://read.qxmd.com/read/38337636/adverse-food-reactions-in-inflammatory-bowel-disease-state-of-the-art-and-future-perspectives
#14
REVIEW
Ivan Capobianco, Federica Di Vincenzo, Pierluigi Puca, Guia Becherucci, Maria Chiara Mentella, Valentina Petito, Franco Scaldaferri
Limited knowledge is available about the relationship between food allergies or intolerances and inflammatory bowel disease (IBD). Clinicians frequently encounter patients who report food allergies or intolerances, and gastroenterologists struggle distinguishing between patients with organic disorders and those with functional disorders, which the patients themselves may associate with specific dietary components. This task becomes even more arduous when managing patients with significant underlying organic conditions, like IBD...
January 25, 2024: Nutrients
https://read.qxmd.com/read/38314171/is-the-mediterranean-diet-in-inflammatory-bowel-diseases-ready-for-prime-time
#15
REVIEW
Lihi Godny, Iris Dotan
BACKGROUND: The rising incidence of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), specifically in the developing world, suggests an important environmental effect. Amongst environmental influences, dietary factors, particularly the adoption of a westernized diet, have been specifically noticed. In contrast, the Mediterranean diet (MED), characterized by high intake of fruits, vegetables, whole grains, legumes, nuts, olive oil, and moderate consumption of animal and ultra processed foods, has shown potential positive effects in IBD...
February 2024: Journal of the Canadian Association of Gastroenterology
https://read.qxmd.com/read/38305329/ultra-processed-food-disease-activity-and-inflammation-in-ulcerative-colitis-the-manitoba-living-with-ibd-study
#16
JOURNAL ARTICLE
Kathy Vagianos, Casandra Dolovich, Kelcie Witges, Lesley A Graff, Charles N Bernstein
INTRODUCTION: The purpose of this study was to investigate the relationship between ultra-processed food (UPF) consumption and (i) symptomatic disease and (ii) intestinal inflammation among adults with inflammatory bowel disease (IBD). METHODS: We identified participants (Crohn's disease [CD] and ulcerative colitis [UC]) from the Manitoba Living with IBD study. Active disease was defined using the IBD Symptom Inventory (score >14 for CD; >13 for UC); fecal calprotectin was measured for intestinal inflammation (>250 μg/g)...
March 8, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38290831/inflammatory-bowel-diseases-are-we-ready-to-recommend-a-preventive-diet-for-infants
#17
JOURNAL ARTICLE
Ashwin N Ananthakrishnan
No abstract text is available yet for this article.
March 7, 2024: Gut
https://read.qxmd.com/read/38280217/unveiling-colitis-a-journey-through-the-dextran-sodium-sulfate-induced-model
#18
JOURNAL ARTICLE
Chunhua Yang, Didier Merlin
Animal models of inflammatory bowel disease (IBD) are valuable tools for investigating the factors involved in IBD pathogenesis and evaluating new therapeutic options. The dextran sodium sulfate (DSS)-induced model of colitis is arguably the most widely used animal model for studying the pathogenesis of and potential treatments for ulcerative colitis (UC), which is a primary form of IBD. This model offers several advantages as a research tool: it is highly reproducible, relatively easy to generate and maintain, and mimics many critical features of human IBD...
January 27, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38279309/intestinal-inflammation-and-regeneration-interdigitating-processes-controlled-by-dietary-lipids-in-inflammatory-bowel-disease
#19
REVIEW
Soon Jae Kwon, Muhammad Sohaib Khan, Sang Geon Kim
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a disease of chronic inflammatory conditions of the intestinal tract due to disturbance of the inflammation and immune system. Symptoms of IBD include abdominal pain, diarrhea, bleeding, reduced weight, and fatigue. In IBD, the immune system attacks the intestinal tract's inner wall, causing chronic inflammation and tissue damage. In particular, interlukin-6 and interlukin-17 act on immune cells, including T cells and macrophages, to amplify the immune responses so that tissue damage and morphological changes occur...
January 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38278200/coconut-water-induces-clinical-remission-in-mild-to-moderate-ulcerative-colitis-double-blind-placebo-controlled-trial
#20
JOURNAL ARTICLE
Saurabh Kedia, Shubi Virmani, Aditya Bajaj, Manasvini Markandey, Neha Singh, Divya Madan, Kanav Kaushal, Pabitra Sahu, Sudheer Kumar Vuyyuru, Bhaskar Kante, Peeyush Kumar, David Mathew Thomas, Sandeep Kumar Mundhra, Mukesh Kumar Singh, Mahak Verma, Raju Sharma, Prasenjit Das, Nihar Ranjan Dash, Nitika Monga, Amit Awasthi, Govind Makharia, Vineet Ahuja
BACKGROUND AND AIMS: Coconut water is anti-inflammatory, can manipulate the gut microbiome and is a rich source of potassium. Gut microbiome modulation improves outcomes in UC, and potassium possesses in vitro anti-inflammatory property. We evaluated the effect of coconut water as an adjunct therapy for patients with mild-moderate UC. METHODS: This single-center double-blind placebo-controlled trial randomized patients with mild-moderate(simple clinical colitis activity index-SCCAI:3-9) endoscopically active UC(ulcerative colitis endoscopic index of severity-UCEIS>1) in 1:1 ratio to coconut water + standard medical therapy-SMT(CW) vs placebo + SMT...
January 24, 2024: Clinical Gastroenterology and Hepatology
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