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https://www.readbyqxmd.com/read/28934714/efficacy-of-dehydroepiandrosterone-dhea-to-overcome-the-effect-of-ovarian-ageing-ditto-a-proof-of-principle-double-blinded-randomized-placebo-controlled-trial
#1
Amarin Narkwichean, Walid Maalouf, Miriam Baumgarten, Lukasz Polanski, Nick Raine-Fenning, Bruce Campbell, Kannamannadiar Jayaprakasan
OBJECTIVE: To evaluate the effect of DHEA supplementation on In-Vitro Fertilisation (IVF) outcome as assessed by ovarian response, oocyte developmental competence and live birth rates in women predicted to have poor ovarian reserve (OR). The feasibility of conducting a large trial is also assessed by evaluating the recruitment rates and compliance of the recruited participants with DHEA/placebo intake and follow-up rates. STUDY DESIGN: A single centre, double blinded, placebo controlled, randomized trial was performed over two years with 60 women undergoing in-vitro fertilisation (IVF)...
September 8, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28934438/placental-but-not-peripheral-plasmodium-falciparum-infection-during-pregnancy-is-associated-with-increased-risk-of-malaria-in-infancy
#2
Sarah Boudová, Titus Divala, Randy Mungwira, Patricia Mawindo, Tamiwe Tomoka, Miriam K Laufer
Pregnancy-associated Plasmodium falciparum infection impacts the health of mothers and newborns, but little is known about the effects of these infections on infant susceptibility to malaria. We followed 473 mother-infant pairs during pregnancy and through 2 years of age. We observed that children born to mothers with placental malaria, but not those born to mothers with peripheral infection without evidence of placental sequestration, had increased risk of malaria during the first year of life compared with children born to mothers with no malaria during pregnancy...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28933826/a-modern-twist-to-a-classic-synthetic-route-ph3bi-based-redox-transmetalation-protolysis-rtp-for-the-preparation-of-barium-metalorganic-species
#3
Yuriko Takahashi, Anna O'Brien, Glen B Deacon, Philip C Andrews, Melanie Wolf, Ana Torvisco, Miriam M Gillett-Kunnath, Karin Ruhlandt-Senge
This paper reports advances in redox transmetalation/protolysis (RTP) utilizing the readily available Ph3Bi for the synthesis of a series of barium metal-organic species. On the basis of easily available starting materials, an easy one-pot procedure, and workup, we have obtained BaL2 compounds (L = bis(trimethylsilyl)amide, phenyl(trimethylsilyl)amide, pentamethylcyclopentadienide, fluorenide, 2,6-di-isopropylphenolate, and 3,5-diphenylpyrazolate) quantitatively by sonication of an excess of barium metal with triphenylbismuth and HL in perdeuterotetrahydrofuran, as established by NMR measurements...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28933744/energy-and-protein-in-critically-ill-patients-with-aki-a-prospective-multicenter-observational-study-using-indirect-calorimetry-and-protein-catabolic-rate
#4
Alice Sabatino, Miriam Theilla, Moran Hellerman, Pierre Singer, Umberto Maggiore, Maria Barbagallo, Giuseppe Regolisti, Enrico Fiaccadori
The optimal nutritional support in Acute Kidney Injury (AKI) still remains an open issue. The present study was aimed at evaluating the validity of conventional predictive formulas for the calculation of both energy expenditure and protein needs in critically ill patients with AKI. A prospective, multicenter, observational study was conducted on adult patients hospitalized with AKI in three different intensive care units (ICU). Nutrient needs were estimated by different methods: the Guidelines of the European Society of Parenteral and Enteral Nutrition (ESPEN) for both calories and proteins, the Harris-Benedict equation, the Penn-State and Faisy-Fagon equations for energy...
July 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28931035/neuroprotection-with-hypothermia-and-allopurinol-in-an-animal-model-of-hypoxic-ischemic-injury-is-it-a-gender-question
#5
Javier Rodríguez-Fanjul, Cristina Durán Fernández-Feijóo, Míriam Lopez-Abad, Maria Goretti Lopez Ramos, Rafael Balada Caballé, Soledad Alcántara-Horillo, Marta Camprubí Camprubí
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) is one of the most important causes of neonatal brain injury. Therapeutic hypothermia (TH) is the standard treatment for term newborns after perinatal hypoxic ischemic injury (HI). Despite this, TH does not provide complete neuroprotection. Allopurinol seems to be a good neuroprotector in several animal studies, but it has never been tested in combination with hypothermia. Clinical findings show that male infants with (HI) fare more poorly than matched females in cognitive outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28930653/fishing-for-answers-in-human-mycobacterial-infections
#6
Miriam Bolz, Joel D Ernst
Two recent studies (Cambier et al., 2017; Madigan et al., 2017) reveal in vivo functions for specific phenolic glycolipids (PGLs) in the mycobacteria that cause tuberculosis or leprosy. M. tuberculosis (and M. marinum) PGL promotes bacterial spread to growth-permissive macrophages, while M. leprae PGL-1 induces macrophages to cause nerve demyelination characteristic of human leprosy.
September 19, 2017: Immunity
https://www.readbyqxmd.com/read/28930082/cryptosporidium-spp-and-giardia-sp-in-aquatic-mammals-in-northern-and-northeastern-brazil
#7
João Carlos Borges, Danielle Dos Lima, Edson Moura da Silva, André Lucas de Oliveira Moreira, Miriam Marmontel, Vitor Luz Carvalho, Rodrigo de Amaral, Stella Maris Lazzarini, Leucio Câmara Alves
Cryptosporidium and Giardia are protozoans that can infect humans and wild and domestic animals. Due to the growing importance of diseases caused by protozoan parasites in aquatic species, we aimed to evaluate the frequency of infection by Cryptosporidium spp. and Giardia sp. in aquatic and marine mammals in the northern and northeastern regions of Brazil. We collected 553 fecal samples from 15 species of wild-ranging and captive aquatic mammals in northern and northeastern Brazil. All samples were analyzed by the Kinyoun technique for identification of Cryptosporidium spp...
September 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28929802/a-study-of-outcomes-of-patients-treated-at-a-uk-major-trauma-centre-for-moderate-or-severe-injuries-one-to-three-years-after-injury
#8
Stephen Spreadborough, Kate Radford, Roshan das Nair, Adam Brooks, Miriam Duffy
OBJECTIVE: To assess return to work outcomes of major trauma patients treated at a level 1 UK major trauma centre and evaluate factors associated with improved outcomes. DESIGN: Cross-sectional cohort design. SUBJECTS: In total, 99 patients at one, two or three years post-discharge from a Major Trauma Centre with an injury severity score above 9, in full-time work or education prior to injury, aged 18-70 and discharged between April 2012 and June 2015...
September 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28929338/a-perspective-on-the-m%C3%A3-ller-cell-neuron-metabolic-partnership-in-the-inner-retina
#9
REVIEW
A K Toft-Kehler, D M Skytt, Miriam Kolko
The Müller cells represent the predominant macroglial cell in the retina. In recent decades, Müller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization, spanning the entire retina being interposed between the vessels and neurons, Müller cells are responsible for the functional and metabolic support of the surrounding neurons. As a consequence of major energy demands in the retina, high levels of glucose are consumed and processed by Müller cells...
September 19, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28927940/chronic-school-absenteeism-and-the-role-of-adverse-childhood-experiences
#10
Hilary Stempel, Matthew Cox-Martin, Michael Bronsert, L Miriam Dickinson, Mandy A Allison
OBJECTIVE: To examine the association between chronic school absenteeism and adverse childhood experiences (ACEs) among school-aged children. METHODS: We conducted a secondary analysis of data from the 2011-2012 National Survey of Children's Health including children 6-17 years old. The primary outcome variable was chronic school absenteeism (> 15 days absent in past year). We examined the association between chronic school absenteeism and ACEs using logistic regression with weighting for individual ACEs, summed ACE score, and latent class analysis of ACEs...
September 16, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28927854/tuberculoma-cavitation-a-rare-aspect-of-a-common-disease-clinical-image
#11
Rosana Souza Rodrigues, Miriam Menna Barreto, Edson Marchiori
No abstract text is available yet for this article.
September 15, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28927820/a-novel-role-for-cilia-function-in-atopy-adgrv1-and-dnah5-interactions
#12
Pierre-Emmanuel Sugier, Myriam Brossard, Chloé Sarnowski, Amaury Vaysse, Andréanne Morin, Lucile Pain, Patricia Margaritte-Jeannin, Marie-Hélène Dizier, William O C M Cookson, Mark Lathrop, Miriam F Moffatt, Catherine Laprise, Florence Demenais, Emmanuelle Bouzigon
BACKGROUND: Atopy, an endotype underlying allergic diseases, has a substantial genetic component. OBJECTIVE: Our goal was to identify novel genes associated with atopy in asthma-ascertained families. METHODS: We implemented a three-step analysis strategy in three datasets: The Epidemiological study on the Genetics and Environment of Asthma (EGEA) dataset: 1,660 subjects; The Saguenay-Lac-Saint-Jean (SLSJ) dataset: 1,138 subjects; and The Medical Research Council (MRC) dataset: 446 subjects)...
September 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28926849/-a-nationwide-survey-of-undergraduate-training-in-orthopaedics-and-trauma-surgery
#13
Miriam Ruesseler, Susanne Froehlich, Sigrid Ruesseler, Julian Zabel, Jasmina Sterz, Udo Obertacke
Background Musculoskeletal conditions are the most frequent cause of long-term pain and disability. Scientifically funded, structured training would be highly desirable for all medical students and of great economic relevance for the health care system. The present article portrays the status quo of undergraduate training in orthopaedics and trauma surgery, with a comparison to the status quo of 2008. Material and Methods A 51-item questionnaire was sent to all heads of the departments of orthopaedics or trauma surgery at the 37 medical faculties in Germany...
September 19, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28926479/fatigue-following-traumatic-brain-injury-in-children-and-adolescents-a-longitudinal-follow-up-6-to-12-months-after-injury
#14
Alison Crichton, Vicki Anderson, Ed Oakley, Mardee Greenham, Stephen Hearps, Carmel Delzoppo, Miriam H Beauchamp, James S Hutchison, Anne-Marie Guerguerian, Kathy Boutis, Franz E Babl
BACKGROUND: Longitudinal fatigue data in children suffering from traumatic brain injury (TBI) are lacking. OBJECTIVES: To examine the effects of time postinjury (6-12 months) and injury severity on fatigue after childhood TBI. Secondarily, we compared fatigue 12 months postinjury against published control data. SETTING: Three tertiary children's hospitals across Australia (n = 1) and Canada (n = 2). PARTICIPANTS: Parents (n = 109) of children (mean [M] = 9...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28924531/efficacy-of-metabolically-supported-chemotherapy-combined-with-ketogenic-diet-hyperthermia-and-hyperbaric-oxygen-therapy-for-stage-iv-triple-negative-breast-cancer
#15
Mehmet Salih İyikesici, Abdul Kadir Slocum, Ayshe Slocum, Ferhan Bulent Berkarda, Miriam Kalamian, Thomas N Seyfried
Triple-negative breast cancer (TNBC) is more aggressive and metastatic than other breast cancer types. Cytotoxic chemotherapy is presently the predominant systemic therapy for TNBC patients. This case report highlights the influence of metabolically supported chemotherapy (MSCT), ketogenic diet (KD), hyperthermia (HT), and hyperbaric oxygen therapy (HBOT) in an overweight 29-year-old woman with stage IV (T4N3M1) triple-negative invasive ductal carcinoma of the breast. The patient presented with an observable mass in her left breast detected during a physical examination in December 2015...
July 7, 2017: Curēus
https://www.readbyqxmd.com/read/28923818/what-makes-for-successful-registry-implementation-a-qualitative-comparative-analysis
#16
Jodi Summers Holtrop, Tristen L Hall, Claude Rubinson, L Miriam Dickinson, Russell E Glasgow
PURPOSE: Registry implementation is an important component of successfully achieving patient-centered medical home designation and an important part of population-based health. The purpose of this study was to examine what factors are evident in the successful implementation of a registry in a selection of Colorado practices involved in quality-improvement activities. METHODS: In-depth, small-group interviews occurred at 13 practices. The data were recorded, transcribed, and qualitatively analyzed to identify key themes regarding elements of successful registry implementation...
September 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28923121/-i-think-it-is-right-a-qualitative-exploration-of-the-acceptability-and-desired-future-use-of-oral-swab-and-finger-prick-hiv-self-tests-by-lay-users-in-kwazulu-natal-south-africa
#17
Lucia Knight, Tawanda Makusha, Jeanette Lim, Roger Peck, Miriam Taegtmeyer, Heidi van Rooyen
BACKGROUND: The uptake of HIV testing has increased in sub-Saharan Africa over the past three decades. However, the proportion of people aware of their HIV status remains lower than required to change the pandemic. HIV self-testing (HIVST) may meet this gap. Assessment of readiness for and the acceptability of HIVST by lay users in South Africa is limited. This paper presents results from a formative study designed to assess the perceived usability and acceptability of HIVST among lay users using several self-test prototypes...
September 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28923050/dry-needling-in-a-manual-physiotherapy-and-therapeutic-exercise-protocol-for-patients-with-chronic-mechanical-shoulder-pain-of-unspecific-origin-a-protocol-for-a-randomized-control-trial
#18
Emma Tejera-Falcón, Nuria Del Carmen Toledo-Martel, Francisco Manuel Sosa-Medina, Fátima Santana-González, Miriam Del Pino Quintana-de la Fe, Tomás Gallego-Izquierdo, Daniel Pecos-Martín
BACKGROUND: Shoulder pain of musculoskeletal origin is the main cause of upper limb pain of non-traumatic origin. Despite being one of the most common reasons for consultation, there is no established protocol for treatment due to the complexity of its etiology. However, it has been shown that the presence of myofascial trigger points on the shoulder muscles is a common condition associated with patients suffering from shoulder pain. This protocol has been created which describes the design of a randomized controlled trial to evaluate the effectiveness of the inclusion of dry needling (DN) within a protocol of manual physiotherapy and therapeutic exercise in the treatment of chronic shoulder pain of unspecific origin...
September 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28922954/determinants-of-carotid-femoral-pulse-wave-velocity-progression-in-hypertensive-patients-over-a-3-7-years-follow-up
#19
Paolo Meani, Alessandro Maloberti, Paola Sormani, Giulia Colombo, Luca Giupponi, Miriam Stucchi, Marisa Varrenti, Paola Vallerio, Rita Facchetti, Guido Grassi, Giuseppe Mancia, Cristina Giannattasio
OBJECTIVE: The role of risk factors on the progression of arterial stiffness has not yet been extensively evaluated. The aim of the current longitudinal study was to evaluate the determinants of the PWV progression over a 4 years follow-up period in hypertensive subjects. MATERIALS AND METHODS: We enrolled 333 consecutive hypertensive outpatients 18-80 aged, followed by the Hypertension Unit of St. Gerardo Hospital (Monza, Italy). At baseline anamnestic, clinical, BP, laboratory data and cfPWV were assessed...
September 18, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28922671/impact-of-elevated-donor-troponin-i-as-predictor-of-adverse-outcome-in-adult-heart-transplantation-a-single-center-experience
#20
Miriam Freundt, Alois Philipp, Philipp Kolat, Leopold Rupprecht, Christine Friedrich, Stephan W Hirt, Assad Haneya
No abstract text is available yet for this article.
September 18, 2017: Thoracic and Cardiovascular Surgeon
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