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https://www.readbyqxmd.com/read/27590297/erratum-to-prism-ii-an-open-label-study-to-assess-effectiveness-of-dextromethorphan-quinidine-for-pseudobulbar-affect-in-patients-with-dementia-stroke-or-traumatic-brain-injury
#1
Flora M Hammond, David N Alexander, Andrew J Cutler, Stephen D'Amico, Rachelle S Doody, William Sauve, Richard D Zorowitz, Charles S Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E Formella, Joao Siffert
No abstract text is available yet for this article.
2016: BMC Neurology
https://www.readbyqxmd.com/read/27425388/rehabilitation-of-visuospatial-neglect-by-prism-adaptation-effects-of-a-mild-treatment-regime-a-randomised-controlled-trial
#2
Nathalie Vaes, Gudrun Nys, Christophe Lafosse, Lutgart Dereymaeker, Kristine Oostra, Dimitri Hemelsoet, Guy Vingerhoets
Closely examining the effects, optimal regime and time window of prism adaptation (PA) promotes guidelines for effective rehabilitation practice. The effects of short-term repetitive PA on spatial neglect manifestations were evaluated in patients with heterogeneous post-stroke delays, using a digital Visuospatial Neglect Test Battery. Subsequently, potential differences in PA effects between acute, subacute or chronic neglect were explored. A multicentre randomised controlled trial was conducted in 43 right-hemisphere neglect patients...
July 18, 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/27379011/visual-rehabilitation-in-chronic-cerebral-blindness-a-randomized-controlled-crossover-study
#3
Joris A Elshout, Freekje van Asten, Carel B Hoyng, Douwe P Bergsma, Albert V van den Berg
The treatment of patients suffering from cerebral blindness following stroke is a topic of much recent interest. Several types of treatment are under investigation, such as substitution with prisms and compensation training of saccades. A third approach, aimed at vision restitution is controversial, as a proper controlled study design is missing. In the current study, 27 chronic stroke patients with homonymous visual field defects were trained at home with a visual training device. We used a discrimination task for two types of stimuli: a static point stimulus and a new optic flow-discontinuity stimulus...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27276999/prism-ii-an-open-label-study-to-assess-effectiveness-of-dextromethorphan-quinidine-for-pseudobulbar-affect-in-patients-with-dementia-stroke-or-traumatic-brain-injury
#4
Flora M Hammond, David N Alexander, Andrew J Cutler, Stephen D'Amico, Rachelle S Doody, William Sauve, Richard D Zorowitz, Charles S Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E Formella, Joao Siffert
BACKGROUND: Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). The PRISM II study provides additional DM/Q experience with PBA secondary to dementia, stroke, or traumatic brain injury (TBI). METHODS: Participants in this open-label, multicenter, 90-day trial received DM/Q 20/10 mg twice daily. The primary outcome was the Center for Neurologic Study-Lability Scale (CNS-LS), assessing change in PBA episode frequency and severity...
June 9, 2016: BMC Neurology
https://www.readbyqxmd.com/read/26834386/the-effects-of-prism-glasses-and-intensive-upper-limb-exercise-on-hemineglect-upper-limb-function-and-activities-of-daily-living-in-stroke-patients-a-case-series
#5
Se-Il Oh, Jin-Kyung Kim, So-Yeon Park
[Purpose] This study aimed to examine the effects of visual field with prism glasses, and intensive upper limb functional training on reduction of hemineglect and improvement in upper limb function and activities of daily living in three stroke patients with hemineglect. [Subjects] This study included three stroke patients hospitalized in a sanatorium. [Methods] Intervention treatment involving prism glass use for 12 hours and 30 minutes and paretic side upper limb training was conducted 5 days a week for 15 weeks...
December 2015: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/26797084/left-insular-damage-autonomic-instability-and-sudden-unexpected-death-in-epilepsy
#6
Nuria Lacuey, Bilal Zonjy, Wanchat Theerannaew, Kenneth A Loparo, Curtis Tatsuoka, Jayakumar Sahadevan, Samden D Lhatoo
We analyzed the only two sudden unexpected death in epilepsy (SUDEP) cases from 320 prospectively recruited patients in the three-year Prevention and Risk Identification of SUDEP Mortality (PRISM) project. Both patients had surgically refractory epilepsy, evidence of left insular damage following previous temporal/temporo-insular resections, and progressive changes in heart rate variability (HRV) in monitored evaluations prior to death. Insular damage is known to cause autonomic dysfunction and increased mortality in acute stroke...
February 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26471212/an-open-label-study-to-assess-safety-tolerability-and-effectiveness-of-dextromethorphan-quinidine-for-pseudobulbar-affect-in-dementia-prism-ii-results
#7
Rachelle S Doody, Stephen D'Amico, Andrew J Cutler, Charles S Davis, Paul Shin, Fred Ledon, Charles Yonan, João Siffert
BACKGROUND: Dextromethorphan (DM)/quinidine (Q) is an approved treatment for pseudobulbar affect (PBA) based on trials in amyotrophic lateral sclerosis or multiple sclerosis. PRISM II evaluated DM/Q effectiveness and tolerability for PBA secondary to dementia, stroke, or traumatic brain injury; dementia cohort results are reported. METHODS: This was an open-label, multicenter, 90 day trial; patients received DM/Q 20/10 mg twice daily. Primary outcome was change in Center for Neurologic Study-Lability Scale (CNS-LS) score...
October 16, 2015: CNS Spectrums
https://www.readbyqxmd.com/read/26163480/use-of-prism-adaptation-in-children-with-unilateral-brain-lesion-is-it-feasible
#8
Inmaculada Riquelme, Camille Henne, Benoit Flament, Valéry Legrain, Yannick Bleyenheuft, Samar M Hatem
INTRODUCTION: Unilateral visuospatial deficits have been observed in children with brain damage. While the effectiveness of prism adaptation for treating unilateral neglect in adult stroke patients has been demonstrated previously, the usefulness of prism adaptation in a pediatric population is still unknown. The present study aims at evaluating the feasibility of prism adaptation in children with unilateral brain lesion and comparing the validity of a game procedure designed for child-friendly paediatric intervention, with the ecological task used for prism adaptation in adult patients...
August 2015: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/26124715/using-brain-potentials-to-understand-prism-adaptation-the-error-related-negativity-and-the-p300
#9
Stephane J MacLean, Cameron D Hassall, Yoko Ishigami, Olav E Krigolson, Gail A Eskes
Prism adaptation (PA) is both a perceptual-motor learning task as well as a promising rehabilitation tool for visuo-spatial neglect (VSN)-a spatial attention disorder often experienced after stroke resulting in slowed and/or inaccurate motor responses to contralesional targets. During PA, individuals are exposed to prism-induced shifts of the visual-field while performing a visuo-guided reaching task. After adaptation, with goggles removed, visuomotor responding is shifted to the opposite direction of that initially induced by the prisms...
2015: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/26106113/effect-of-intravenous-recombinant-tissue-type-plasminogen-activator-in-patients-with-mild-stroke-in-the-third-international-stroke-trial-3-post-hoc-analysis
#10
RANDOMIZED CONTROLLED TRIAL
Pooja Khatri, Darren Tayama, Geoff Cohen, Richard I Lindley, Joanna M Wardlaw, Sharon D Yeatts, Joseph P Broderick, Peter Sandercock
BACKGROUND AND PURPOSE: Randomized trial evidence on the risk/benefit ratio of thrombolysis for mild stroke is limited. We sought to determine the efficacy of intravenous recombinant tissue-type plasminogen activator (IV r-tPA) in a subset of patients with mild deficit in the third International Stroke Trial (IST-3). METHODS: IST-3 compared IV r-tPA with control within 6 hours of onset in patients for whom IV r-tPA was considered promising but unproven. Analysis was restricted to subjects randomized within 3 hours of onset with a baseline National Institutes of Health Stroke Scale ≤5, pretreatment blood pressure <185/110, and no other r-tPA exclusion criteria...
August 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/25983688/prism-adaptation-and-spatial-neglect-the-need-for-dose-finding-studies
#11
Kelly M Goedert, Jeffrey Y Zhang, A M Barrett
Spatial neglect is a devastating disorder in 50-70% of right-brain stroke survivors, who have problems attending to, or making movements towards, left-sided stimuli, and experience a high risk of chronic dependence. Prism adaptation is a promising treatment for neglect that involves brief, daily visuo-motor training sessions while wearing optical prisms. Its benefits extend to functional behaviors such as dressing, with effects lasting 6 months or longer. Because one to two sessions of prism adaptation induce adaptive changes in both spatial-motor behavior (Fortis et al...
2015: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/25673965/thermomechanical-actuator-based-three-axis-optical-scanner-for-high-speed-two-photon-endomicroscope-imaging
#12
Shih-Chi Chen, Heejin Choi, Peter T C So, Martin L Culpepper
This paper presents the design and characterization of a three-axis thermomechanical actuator-based endoscopic scanner for obtaining ex vivo two-photon images. The scanner consisted of two sub-systems: 1) an optical system (prism, gradient index lens, and optical fiber) that was used to deliver and collect light during imaging and 2) a small-scale silicon electromechanical scanner that could raster scan the focal point of the optics through a specimen. The scanner can be housed within a 7 mm Ø endoscope port and can scan at the speed of 3 kHz × 100 Hz × 30 Hz along three axes throughout a 125 × 125 × 100 μm(3) volume...
May 29, 2014: Journal of Microelectromechanical Systems
https://www.readbyqxmd.com/read/25648350/study-protocol-of-prism-adaptation-in-rehabilitation-a-randomized-controlled-trial-in-stroke-patients-with-neglect
#13
RANDOMIZED CONTROLLED TRIAL
Antonia F Ten Brink, Johanna M A Visser-Meily, Tanja C W Nijboer
BACKGROUND: A frequent disorder after stroke is neglect, resulting in a failure to report or respond to contralesional stimuli. Rehabilitation of neglect is important, given the negative influence on motor recovery, independence in self-care, transfers, and locomotion. Effects of prism adaptation (PA) to alleviate neglect have been reported. However, either small groups or no control group were included and few studies reported outcome measurements on the level of activities of daily living (ADL)...
February 4, 2015: BMC Neurology
https://www.readbyqxmd.com/read/25638754/comparison-of-statistical-and-operational-properties-of-subject-randomization-procedures-for-large-multicenter-clinical-trial-treating-medical-emergencies
#14
COMPARATIVE STUDY
Wenle Zhao, Yunming Mu, Darren Tayama, Sharon D Yeatts
Large multicenter acute stroke trials demand a randomization procedure with a high level of treatment allocation randomness, an effective control on overall and within-site imbalances, and a minimized time delay of study treatment caused by the randomization procedure. Driven by the randomization algorithm design of A Study of the Efficacy and Safety of Activase (Alteplase) in Patients with Mild Stroke (PRISMS) (NCT02072226), this paper compares operational and statistical properties of different randomization algorithms in local, central, and step-forward randomization settings...
March 2015: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/25543183/long-term-sensorimotor-and-therapeutical-effects-of-a-mild-regime-of-prism-adaptation-in-spatial-neglect-a-double-blind-rct-essay
#15
G Rode, S Lacour, S Jacquin-Courtois, L Pisella, C Michel, P Revol, N Alahyane, J Luauté, S Gallagher, P Halligan, D Pélisson, Y Rossetti
Spatial neglect (SN) is commonly associated with poor functional outcome. Adaptation to a rightward optical deviation of vision has been shown to benefit to SN rehabilitation. The neurophysiological foundations and the optimal modalities of prism adaptation (PA) therapy however remain to be validated. This study is aimed at exploring the long-term sensory-motor, cognitive and functional effects produced by weekly PA sessions over a period of four weeks. A double-blind, monocentric randomized and controlled trial (RCT) was carried out...
April 2015: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/25420446/dextromethorphan-quinidine-a-review-of-its-use-in-adults-with-pseudobulbar-affect
#16
REVIEW
Lily P H Yang, Emma D Deeks
Fixed-dose dextromethorphan/quinidine capsules (Nuedexta(®)) utilize quinidine to inhibit the metabolism of dextromethorphan, enabling high plasma dextromethorphan concentrations to be reached without using a larger dose of the drug. The drug combination is the first treatment to be approved for pseudobulbar affect (PBA), a condition of contextually inappropriate/exaggerated emotional expression that often occurs in adults with neurological damage conditions, such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, traumatic brain injury, Alzheimer's disease or Parkinson's disease...
January 2015: Drugs
https://www.readbyqxmd.com/read/25115760/a-seeming-paradox-ischemic-stroke-in-the-context-of-idiopathic-thrombocytopenic-purpura
#17
REVIEW
Ján Mihalov, Gabriela Timárová
Nowadays, we have a relatively sophisticated standard approach to a patient with acute ischemic stroke, including the sequence of diagnostic methods and treatment modalities. In practice, however, we are occasionally confronted with a patient whose medical history or comorbidities force us to make a decision without the support of guidelines. One such situation is the occurrence of acute ischemic stroke in a patient with known idiopathic thrombocytopenic purpura, where a tendency to use thrombolysis, anticoagulants, or antiplatelet agents collides with the fear of life-threatening bleeding...
March 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/25034632/a-randomised-controlled-trial-to-compare-the-clinical-and-cost-effectiveness-of-prism-glasses-visual-search-training-and-standard-care-in-patients-with-hemianopia-following-stroke-a-protocol
#18
RANDOMIZED CONTROLLED TRIAL
F J Rowe, P G Barton, E Bedson, R Breen, E J Conroy, E Cwiklinski, C Dodridge, A Drummond, M Garcia-Finana, C Howard, S Johnson, C MacIntosh, C P Noonan, A Pollock, J Rockliffe, C Sackley, T Shipman
INTRODUCTION: Homonymous hemianopia is a common and disabling visual problem after stroke. Currently, prism glasses and visual scanning training are proposed to improve it. The aim of this trial is to determine the effectiveness of these interventions compared to standard care. METHODS AND ANALYSIS: The trial will be a multicentre three arm individually randomised controlled trial with independent assessment at 6 week, 12 week and 26 week post-randomisation...
July 17, 2014: BMJ Open
https://www.readbyqxmd.com/read/25005514/evidence-based-review-of-interventions-for-medically-at-risk-older-drivers
#19
REVIEW
Sherrilene Classen, Miriam Monahan, Beth Auten, Abraham Yarney
OBJECTIVE. To conduct an evidence-based review of intervention studies of older drivers with medical conditions. METHOD. We used the American Occupational Therapy Association's classification criteria (Levels I-V, I = highest level of evidence) to identify driving interventions. We classified studies using letters to represent the strength of recommendations: A = strongly recommend the intervention; B = recommend intervention is provided routinely; C = weak evidence that the intervention can improve outcomes; D = recommend not to provide the intervention; I = insufficient evidence to recommend for or against the intervention...
July 2014: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/24965103/automated-versus-manual-hippocampal-segmentation-in-preoperative-and-postoperative-patients-with-epilepsy
#20
Sierra C Germeyan, David Kalikhman, Lucy Jones, William H Theodore
OBJECTIVE: To compare manual and automated preoperative and postoperative hippocampal volume measurements in patients with intractable epilepsy. METHODS: We studied 34 patients referred to the Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH) for evaluation of intractable epilepsy and 21 normal volunteers who received 1.5 or 3 T GE Signa magnetic resonance imaging (MRI) scans. Hippocampal volumes were traced manually on each slice and assembled into three-dimensional volumes by investigators who were blinded to other data...
September 2014: Epilepsia
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