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https://www.readbyqxmd.com/read/29201538/vision-in-stroke-cohort-profile-overview-of-visual-impairment
#1
Fiona J Rowe
Aim: To profile the full range of visual disorders from a large prospective observation study of stroke survivors referred by stroke multidisciplinary teams to orthoptic services with suspected visual problems. Methods: Multicenter prospective study undertaken in 20 acute Trust hospitals. Standardized screening/referral forms and investigation forms documented data on referral signs and symptoms plus type and extent of visual impairment. Results: Of 1,345 patients referred with suspected visual impairment, 915 were recruited (59% men; mean age at stroke onset 69 years [SD 14])...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29192634/the-pattern-of-significant-lesions-found-in-computerized-tomography-scan-of-recurrent-seizure-patients-at-a-center-in-enugu-nigeria
#2
A B Ezeala-Adikaibe, S C Ohaegbulam, C A Ndubuisi
INTRODUCTION: Seizures are common reasons for neurologic consultations and investigations. In the absence of magnetic resonance imaging, computerized tomography scanning of the brain is a reliable and cheaper alternative. Little is known about the pattern of brain lesions in patients with recurrent seizures in Nigeria. OBJECTIVES: To determine the pattern of significant intracerebral lesions in patients presenting with recurrent seizures in a tertiary hospital in Enugu...
October 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29192535/prism-adaptation-in-rehabilitation-no-additional-effects-of-prism-adaptation-on-neglect-recovery-in-the-subacute-phase-poststroke-a-randomized-controlled-trial
#3
Antonia F Ten Brink, Johanna M A Visser-Meily, Martijn J Schut, Mirjam Kouwenhoven, Anja L H Eijsackers, Tanja C W Nijboer
BACKGROUND: Patients with neglect ignore or respond slower to contralesional stimuli. Neglect negatively influences independence in activities of daily living (ADL). Prism adaptation (PA) is one of the most frequently studied treatments, yet there is little evidence regarding positive effects on neglect behavior in ADL. OBJECTIVE: To assess whether PA in the subacute phase ameliorates neglect in situations of varying complexity. METHODS: A total of 70 neglect patients admitted for inpatient stroke rehabilitation received either PA or sham adaptation (SA) for 2 weeks, with full access to standard treatment...
November 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28984724/neuro-ophthalmic-manifestations-of-cerebrovascular-accidents
#4
REVIEW
Alaa S Bou Ghannam, Prem S Subramanian
PURPOSE OF REVIEW: Ocular functions can be affected in almost any type of cerebrovascular accident (CVA) creating a burden on the patient and family and limiting functionality. The present review summarizes the different ocular outcomes after stroke, divided into three categories: vision, ocular motility, and visual perception. We also discuss interventions that have been proposed to help restore vision and perception after CVA. RECENT FINDINGS: Interventions that might help expand or compensate for visual field loss and visuospatial neglect include explorative saccade training, prisms, visual restoration therapy (VRT), and transcranial direct current stimulation (tDCS)...
November 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28969107/intracarotid-sodium-nitroprusside-on-fifth-post-ischemic-stroke-day-in-middle-cerebral-artery-occlusion-rat-model
#5
Vinod Kumar Tewari, Vivek Bhosale, Rakesh Shukla, Hari Kishan Das Gupta, Sheeba
INTRODUCTION: Ischemic stroke at later stages (>4.5 hour) have very few treatment options left. In those cases Nitric Oxide (NO) may provide promising results. NO is active in signaling pathways. Sodium Nitroprusside (SNP), a NO donor was tested earlier in rat Middle Cerebral Artery Occlusion (MCAO) model in early stages (5-60 minutes) and found useful but in delayed stroke cases (60-120 minutes) found useless. This was due to local inducible Nitric Oxide Synthase Enzyme (iNOS) and superoxide (causes destructive effect) formation which was skipped...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28888968/role-of-botulinum-toxin-a-in-treatment-of-intractable-diplopia
#6
Seyhan B Özkan, Ayşe İpek Akyüz Ünsal
PURPOSE: To evaluate the effect of botulinum toxin A (BTXA) in patients with intractable diplopia related to intracranial problems or long-term interruption of fusion due to cataract or uncorrected aphakia and to identify the group of resistant cases who have no potential to fuse the two images. METHODS: The medical records of patients seen by the senior author (SBÖ) over a period of 20 years were reviewed retrospectively to identify those who underwent BTXA treatment for intractable diplopia...
October 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28813816/computational-rehabilitation-of-neglect-using-state-space-models-to-understand-the-recovery-mechanisms
#7
Giulia Sedda, Marcella Ottonello, Elena Fiabane, Caterina Pistarini, Anna Sedda, Vittorio Sanguineti
Unilateral spatial neglect is a neuropsychological syndrome often observed in right hemisphere stroke patients. The symptoms differ from subject to subject. A few rehabilitation approaches, e.g. prism adaptation, have demonstrated some effect in reducing the symptoms, but the underlying mechanisms are still largely unclear. Recently, neural models have been proposed to qualitatively describe cortical lesions, the resulting neglect symptoms and the effects of treatment. However, these predictions are qualitative and cannot be used to compare different hypotheses or to interpret symptoms at individual subjects level...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28759299/international-practice-in-care-provision-for-post-stroke-visual-impairment
#8
Fiona J Rowe
PURPOSE: This study sought to explore the practice of orthoptists internationally in care provision for poststroke visual impairment. METHODS: Survey questions were developed and piloted with clinicians, academics, and users. Questions addressed types of visual problems, how these were identified, treated, and followed up, care pathways in use, links with other professions, and referral options. The survey was approved by the institutional ethical committee. The survey was accessed via a web link that was circulated through the International Orthoptic Association member professional organisations to orthoptists...
September 2017: Strabismus
https://www.readbyqxmd.com/read/28134053/what-is-the-value-of-conducting-a-trial-of-r-tpa-for-the-treatment-of-mild-stroke-patients
#9
RANDOMIZED CONTROLLED TRIAL
Gregory F Guzauskas, Er Chen, Deepa Lalla, Elaine Yu, Darren Tayama, David L Veenstra
Background The Phase IIIb, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of Alteplase in Patients With Mild Stroke: Rapidly Improving Symptoms and Minor Neurologic Deficits (PRISMS) trial will assess r-tPA in ischemic stroke patients who present with mild deficits (i.e. mild stroke). Aims To assess PRISMS's societal value in clarifying the optimal care for patients with mild ischemic stroke. Methods A value of information (VOI) decision model was developed to compare the outcomes of mild stroke patients treated vs...
February 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28039678/studying-the-neural-bases-of-prism-adaptation-using-fmri-a-technical-and-design-challenge
#10
Janet H Bultitude, Alessandro Farnè, Romeo Salemme, Danielle Ibarrola, Christian Urquizar, Jacinta O'Shea, Jacques Luauté
Prism adaptation induces rapid recalibration of visuomotor coordination. The neural mechanisms of prism adaptation have come under scrutiny since the observations that the technique can alleviate hemispatial neglect following stroke, and can alter spatial cognition in healthy controls. Relative to non-imaging behavioral studies, fMRI investigations of prism adaptation face several challenges arising from the confined physical environment of the scanner and the supine position of the participants. Any researcher who wishes to administer prism adaptation in an fMRI environment must adjust their procedures enough to enable the experiment to be performed, but not so much that the behavioral task departs too much from true prism adaptation...
December 30, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/28028819/a-pilot-randomized-controlled-trial-comparing-effectiveness-of-prism-glasses-visual-search-training-and-standard-care-in-hemianopia
#11
F J Rowe, E J Conroy, E Bedson, E Cwiklinski, A Drummond, M García-Fiñana, C Howard, A Pollock, T Shipman, C Dodridge, C MacIntosh, S Johnson, C Noonan, G Barton, C Sackley
OBJECTIVE: Pilot trial to compare prism therapy and visual search training, for homonymous hemianopia, to standard care (information only). METHODS: Prospective, multicentre, parallel, single-blind, three-arm RCT across fifteen UK acute stroke units. PARTICIPANTS: Stroke survivors with homonymous hemianopia. INTERVENTIONS: Arm a (Fresnel prisms) for minimum 2 hours, 5 days per week over 6 weeks. Arm b (visual search training) for minimum 30 minutes, 5 days per week over 6 weeks...
December 27, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27966401/-treatment-of-neglect-an-attention-disorder
#12
A F Ten Brink, T C W Nijboer, J M A Visser-Meily
- Neglect occurs in 30-50% of patients in the subacute phase post-stroke. Patients with neglect ignore one side of their body or one part of the space around them. - Treatment of neglect is important, as patients with neglect recover more slowly and are less independent compared to patients without neglect.- Visual scanning training is currently recommended in the guidelines as a treatment. The focus of this intensive treatment is on compensation, not on recovery. Scientific evidence for its effectiveness is scarce...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27928375/a-randomised-controlled-trial-of-treatment-for-post-stroke-homonymous-hemianopia-screening-and-recruitment
#13
Fiona J Rowe, Elizabeth J Conroy, P Graham Barton, Emma Bedson, Emma Cwiklinski, Caroline Dodridge, Avril Drummond, Marta Garcia-Finana, Claire Howard, Stevie Johnson, Claire MacIntosh, Carmel P Noonan, Alex Pollock, Janet Rockliffe, Catherine M Sackley, Tracey Shipman
The authors report the screening process and recruitment figures for the VISION (Visual Impairment in Stroke; Intervention Or Not) trial. This is a prospective, randomised, single-blinded, three-arm controlled trial in 14 UK acute hospital stroke units. Stroke teams identified stroke survivors suspected as having homonymous hemianopia. Interventions included Fresnel prisms versus visual search training versus standard care (information only). Primary outcome was change in visual field assessment from baseline to 26 weeks...
February 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27590297/erratum-to-prism-ii-an-open-label-study-to-assess-effectiveness-of-dextromethorphan-quinidine-for-pseudobulbar-affect-in-patients-with-dementia-stroke-or-traumatic-brain-injury
#14
Flora M Hammond, David N Alexander, Andrew J Cutler, Stephen D'Amico, Rachelle S Doody, William Sauve, Richard D Zorowitz, Charles S Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E Formella, Joao Siffert
No abstract text is available yet for this article.
2016: BMC Neurology
https://www.readbyqxmd.com/read/27425388/rehabilitation-of-visuospatial-neglect-by-prism-adaptation-effects-of-a-mild-treatment-regime-a-randomised-controlled-trial
#15
Nathalie Vaes, Gudrun Nys, Christophe Lafosse, Lutgart Dereymaeker, Kristine Oostra, Dimitri Hemelsoet, Guy Vingerhoets
Closely examining the effects, optimal regime and time window of prism adaptation (PA) promotes guidelines for effective rehabilitation practice. The effects of short-term repetitive PA on spatial neglect manifestations were evaluated in patients with heterogeneous post-stroke delays, using a digital Visuospatial Neglect Test Battery. Subsequently, potential differences in PA effects between acute, subacute or chronic neglect were explored. A multicentre randomised controlled trial was conducted in 43 right-hemisphere neglect patients...
July 18, 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/27379011/visual-rehabilitation-in-chronic-cerebral-blindness-a-randomized-controlled-crossover-study
#16
Joris A Elshout, Freekje van Asten, Carel B Hoyng, Douwe P Bergsma, Albert V van den Berg
The treatment of patients suffering from cerebral blindness following stroke is a topic of much recent interest. Several types of treatment are under investigation, such as substitution with prisms and compensation training of saccades. A third approach, aimed at vision restitution is controversial, as a proper controlled study design is missing. In the current study, 27 chronic stroke patients with homonymous visual field defects were trained at home with a visual training device. We used a discrimination task for two types of stimuli: a static point stimulus and a new optic flow-discontinuity stimulus...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27276999/prism-ii-an-open-label-study-to-assess-effectiveness-of-dextromethorphan-quinidine-for-pseudobulbar-affect-in-patients-with-dementia-stroke-or-traumatic-brain-injury
#17
RANDOMIZED CONTROLLED TRIAL
Flora M Hammond, David N Alexander, Andrew J Cutler, Stephen D'Amico, Rachelle S Doody, William Sauve, Richard D Zorowitz, Charles S Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E Formella, Joao Siffert
BACKGROUND: Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). The PRISM II study provides additional DM/Q experience with PBA secondary to dementia, stroke, or traumatic brain injury (TBI). METHODS: Participants in this open-label, multicenter, 90-day trial received DM/Q 20/10 mg twice daily. The primary outcome was the Center for Neurologic Study-Lability Scale (CNS-LS), assessing change in PBA episode frequency and severity...
June 9, 2016: BMC Neurology
https://www.readbyqxmd.com/read/26834386/the-effects-of-prism-glasses-and-intensive-upper-limb-exercise-on-hemineglect-upper-limb-function-and-activities-of-daily-living-in-stroke-patients-a-case-series
#18
Se-Il Oh, Jin-Kyung Kim, So-Yeon Park
[Purpose] This study aimed to examine the effects of visual field with prism glasses, and intensive upper limb functional training on reduction of hemineglect and improvement in upper limb function and activities of daily living in three stroke patients with hemineglect. [Subjects] This study included three stroke patients hospitalized in a sanatorium. [Methods] Intervention treatment involving prism glass use for 12 hours and 30 minutes and paretic side upper limb training was conducted 5 days a week for 15 weeks...
December 2015: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/26797084/left-insular-damage-autonomic-instability-and-sudden-unexpected-death-in-epilepsy
#19
Nuria Lacuey, Bilal Zonjy, Wanchat Theerannaew, Kenneth A Loparo, Curtis Tatsuoka, Jayakumar Sahadevan, Samden D Lhatoo
We analyzed the only two sudden unexpected death in epilepsy (SUDEP) cases from 320 prospectively recruited patients in the three-year Prevention and Risk Identification of SUDEP Mortality (PRISM) project. Both patients had surgically refractory epilepsy, evidence of left insular damage following previous temporal/temporo-insular resections, and progressive changes in heart rate variability (HRV) in monitored evaluations prior to death. Insular damage is known to cause autonomic dysfunction and increased mortality in acute stroke...
February 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26471212/an-open-label-study-to-assess-safety-tolerability-and-effectiveness-of-dextromethorphan-quinidine-for-pseudobulbar-affect-in-dementia-prism-ii-results
#20
Rachelle S Doody, Stephen D'Amico, Andrew J Cutler, Charles S Davis, Paul Shin, Fred Ledon, Charles Yonan, João Siffert
BACKGROUND: Dextromethorphan (DM)/quinidine (Q) is an approved treatment for pseudobulbar affect (PBA) based on trials in amyotrophic lateral sclerosis or multiple sclerosis. PRISM II evaluated DM/Q effectiveness and tolerability for PBA secondary to dementia, stroke, or traumatic brain injury; dementia cohort results are reported. METHODS: This was an open-label, multicenter, 90 day trial; patients received DM/Q 20/10 mg twice daily. Primary outcome was change in Center for Neurologic Study-Lability Scale (CNS-LS) score...
December 2016: CNS Spectrums
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