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https://www.readbyqxmd.com/read/27911246/role-of-follow-up-imaging-after-resection-of-brain-arteriovenous-malformations-in-pediatric-patients-a-systematic-review-of-the-literature
#1
Joaquin E Jimenez, Zachary C Gersey, Jason Wagner, Brian Snelling, Sudheer Ambekar, Eric C Peterson
OBJECTIVE Pediatric patients are at risk for the recurrence of brain arteriovenous malformation (AVM) after resection. While there is general consensus on the importance of follow-up after surgical removal of an AVM, there is a lack of consistency in the duration of that follow-up. The object of this systematic review was to examine the role of follow-up imaging in detecting AVM recurrence early and preventing AVM rupture. METHODS This systematic review was performed using articles obtained through a search of the literature contained in the MeSH database, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
December 2, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27909879/investigating-vaginal-bleeding-in-postmenopausal-women-found-to-have-an-endometrial-thickness-of-equal-to-or-greater-than-10%C3%A2-mm-on-ultrasonography
#2
Hilary L Turnbull, Nikolaos Akrivos, Paul Simpson, Timothy J Duncan, Joaquin J Nieto, Nikolaos Burbos
PURPOSE: This aim of this study is to determine the risk of endometrial cancer in symptomatic postmenopausal women, when endometrial thickness on transvaginal ultrasonography is equal to or greater than 10 mm, and subsequent office-based endometrial sampling histology is negative. METHODS: This is a prospective cross-sectional study, performed in a gynaecological oncology centre in the United Kingdom between February 2008 and July 2012. All postmenopausal women presenting with vaginal bleeding were investigated using transvaginal ultrasonography...
December 1, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27909475/ablation-of-atrial-fibrillation-in-combination-with-left-atrial-appendage-occlusion-in-a-single-procedure-rationale-and-technique
#3
REVIEW
Ignacio García-Bolao, Naiara Calvo, Alfonso Macias, Joaquin Barba, Nahikari Salterain, Pablo Ramos, Gabriel Ballesteros, Renzo Neglia
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and is associated with a fivefold increase in the risk of ischemic stroke and systemic embolism. Left atrial appendage (LAA) is the source of thrombi in up to 90% of patients with nonvalvular atrial fibrillation (AF). Although thromboembolic prophylaxis by means of oral anticoagulants (OAC) has been shown to be very effective (OAC), they also confer an inevitably risk of serious bleeding. Catheter ablation (CA) is an effective treatment for symptomatic AF but its role in stroke prevention remains unproved...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908974/effects-of-a-humor-therapy-program-on-stress-levels-in-pediatric-inpatients
#4
Julio C Sánchez, Luis F Echeverri, Manuel J Londoño, Sergio A Ochoa, Andrés F Quiroz, César R Romero, Joaquín O Ruiz
OBJECTIVE: Disease and hospitalization generate stress, which can affect the response to treatment. Humor has been used in many hospitals to decrease stress. The aim of this study was to evaluate the impact of a humor therapy program on stress levels in pediatric inpatients. METHODS: In the first phase, an intervention and a control group were studied over 2 consecutive 3-month periods; the interventions were performed by a team of artists trained in humor therapy...
December 1, 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27907196/the-potential-for-conservation-tillage-adoption-in-the-san-joaquin-valley-california-a-qualitative-study-of-farmer-perspectives-and-opportunities-for-extension
#5
Anne V Bossange, Kandace M Knudson, Anil Shrestha, Ronald Harben, Jeffrey P Mitchell
Conservation tillage (CT) systems have a number of potential benefits including lower crop production costs and the ability to reduce soil erosion that have made them common in several regions of the world. Although CT systems have been researched and successfully implemented on some farms in California's San Joaquin Valley (SJV), overall adoption is low and the reasons for the region's comparatively low rates of adoption are not known. In 2011, we conducted written surveys and interviews with SJV farmers to identify characteristics of farmers who adopt or do not adopt CT, to determine reasons for non-adoption of CT, and to learn how successful CT adoption takes place in the SJV...
2016: PloS One
https://www.readbyqxmd.com/read/27906695/metformin-induced-generalized-fixed-drug-eruption-with-cutaneous-hemophagocytosis
#6
Jose Luis Rodríguez-Belver, Joaquin Lopez, Elena Macias, Laura Fuertes, Irene Andres, Victoria Alegria, Ignacio Gimeno, Alejandra Perez, Yosmar Perez, Luis Requena
Fixed drug eruption (FDE) consists of recurrent dusky-red to brownish macules or patches at the same sites after the readministration of the causative drug. It usually presents as a solitary lesion, but generalized eruptions have been described. The most frequently implied drugs are antibiotics, anticonvulsants, and analgesics. Only 2 cases due to metformin have been reported. Histopathologic features of FDE include vacuolar degeneration of the basal layer, necrotic keratinocytes, and superficial and deep perivascular lymphocytic infiltrate...
November 29, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27905644/requests-of-laboratory-tests-for-the-diagnosis-and-management-of-calcium-phosphate-disorders-in-spain
#7
María Salinas, Maite López-Garrigós, Emilio Flores, Joaquín Uris, Carlos Leiva-Salinas
BACKGROUND: Knowledge about the variability in the request of calcium-phosphate metabolism laboratory tests in primary care is important to design strategies to improve health system efficiency. AIM: To compare the inter-practice variability in calcium-phosphate metabolism laboratory tests requested by general practitioners from diverse regions across Spain. MATERIAL AND METHODS: One hundred and forty one clinical laboratories were invited to participate in an observational cross-sectional study...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27893441/engineering-tumor-cell-targeting-in-nanoscale-amyloidal-materials
#8
Ugutz Unzueta, Joaquin Seras-Franzoso, María Virtudes Céspedes, Paolo Saccardo, Francisco Cortés, Fabián Rueda, Elena Garcia-Fruitós, Neus Ferrer-Miralles, Ramon Mangues, Esther Vázquez, Antonio Villaverde
Bacterial inclusion bodies are non-toxic, mechanically stable and functional protein amyloids within the nanoscale size range that are able to naturally penetrate into mammalian cells, where they deliver the embedded protein in a functional form. The potential use of inclusion bodies in protein delivery or protein replacement therapies is strongly impaired by the absence of specificity in cell binding and penetration, thus preventing targeting. To address this issue, we have here explored whether the genetic fusion of two tumor-homing peptides, the CXCR4 ligands R9 and T22, to an inclusion body-forming green fluorescent protein (GFP), would keep the interaction potential and the functionality of the fused peptides and then confer CXCR4 specificity in cell binding and further uptake of the materials...
November 28, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27891818/exploiting-deep-eutectic-solvents-and-organolithium-reagent-partnerships-chemoselective-ultrafast-addition-to-imines-and-quinolines-under-aerobic-ambient-temperature-conditions
#9
Cristian Vidal, Joaquín García-Álvarez, Alberto Hernán-Gómez, Alan R Kennedy, Eva Hevia
Shattering the long-held dogma that organolithium chemistry needs to be performed under inert atmospheres in toxic organic solvents, chemoselective addition of organolithium reagents to non-activated imines and quinolines has been accomplished in green, biorenewable deep eutectic solvents (DESs) at room temperature and in the presence of air, establishing a novel and sustainable access to amines. Improving on existing methods, this approach proceeds in the absence of additives; occurs without competitive enolization, reduction or coupling processes; and reactions were completed in seconds...
November 28, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27890462/radiation-pneumonitis-following-hepatic-yttrium-90-radioembolization
#10
Horacio Matías Castro, Esteban Javier Wainstein, Joaquin Maritano Furcada
No abstract text is available yet for this article.
November 24, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27889801/production-and-purification-of-an-untagged-recombinant-pneumococcal-surface-protein-a-pspa4pro-with-high-purity-and-low-endotoxin-content
#11
Douglas B Figueiredo, Eneas Carvalho, Mauricio P Santos, Stefanie Kraschowetz, Rafaela T Zanardo, Gilson Campani, Gabriel G Silva, Cíntia R Sargo, Antonio Carlos L Horta, Roberto de C Giordano, Eliane N Miyaji, Teresa C Zangirolami, Joaquin Cabrera-Crespo, Viviane Maimoni Gonçalves
Streptococcus pneumoniae is the main cause of pneumonia, meningitis, and other conditions that kill thousands of children every year worldwide. The replacement of pneumococcal serotypes among the vaccinated population has evidenced the need for new vaccines with broader coverage and driven the research for protein-based vaccines. Pneumococcal surface protein A (PspA) protects S. pneumoniae from the bactericidal effect of human apolactoferrin and prevents complement deposition. Several studies indicate that PspA is a very promising target for novel vaccine formulations...
November 26, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27888013/epicardial-adipose-tissue-in-the-general-middle-aged-population-and-its-association-with-metabolic-syndrome
#12
Álvaro Calabuig, Joaquín Barba, María Jesús Guembe, Javier Díez, Jesús Berjón, Eduardo Martínez-Vila, Pablo Irimia, Estefanía Toledo
INTRODUCTION AND OBJECTIVES: There is currently increasing interest in epicardial adipose tissue (EAT) as a marker of cardiovascular disease. Our purpose was to describe EAT, measured by transthoracic echocardiography, and to assess its association with metabolic syndrome (MS) in the RIVANA population-based study. METHODS: Physical examination was performed in 880 participants aged 45 to 74 years (492 of them with MS according to the harmonized definition). Fasting glucose, high-density lipoprotein cholesterol, triglyceride, and C-reactive protein concentrations were determined in a blood sample...
November 22, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27886130/emotion-bracelet-a-web-service-for-expressing-emotions-through-an-electronic-interface
#13
Alicia Martinez, Hugo Estrada, Alejandra Molina, Manuel Mejia, Joaquin Perez
The mechanisms to communicate emotions have dramatically changed in the last 10 years with social networks, where users massively communicate their emotional states by using the Internet. However, people with socialization problems have difficulty expressing their emotions verbally or interpreting the environment and providing an appropriate emotional response. In this paper, a novel solution called the Emotion-Bracelet is presented that combines a hardware device and a software system. The proposed approach identifies the polarity and emotional intensity of texts published on a social network site by performing real-time processing using a web service...
November 24, 2016: Sensors
https://www.readbyqxmd.com/read/27885030/social-status-alters-immune-regulation-and-response-to-infection-in-macaques
#14
Noah Snyder-Mackler, Joaquín Sanz, Jordan N Kohn, Jessica F Brinkworth, Shauna Morrow, Amanda O Shaver, Jean-Christophe Grenier, Roger Pique-Regi, Zachary P Johnson, Mark E Wilson, Luis B Barreiro, Jenny Tung
Social status is one of the strongest predictors of human disease risk and mortality, and it also influences Darwinian fitness in social mammals more generally. To understand the biological basis of these effects, we combined genomics with a social status manipulation in female rhesus macaques to investigate how status alters immune function. We demonstrate causal but largely plastic social status effects on immune cell proportions, cell type-specific gene expression levels, and the gene expression response to immune challenge...
November 25, 2016: Science
https://www.readbyqxmd.com/read/27884981/tissue-damage-and-senescence-provide-critical-signals-for-cellular-reprogramming-in-vivo
#15
Lluc Mosteiro, Cristina Pantoja, Noelia Alcazar, Rosa M Marión, Dafni Chondronasiou, Miguel Rovira, Pablo J Fernandez-Marcos, Maribel Muñoz-Martin, Carmen Blanco-Aparicio, Joaquin Pastor, Gonzalo Gómez-López, Alba De Martino, Maria A Blasco, María Abad, Manuel Serrano
Reprogramming of differentiated cells into pluripotent cells can occur in vivo, but the mechanisms involved remain to be elucidated. Senescence is a cellular response to damage, characterized by abundant production of cytokines and other secreted factors that, together with the recruitment of inflammatory cells, result in tissue remodeling. Here, we show that in vivo expression of the reprogramming factors OCT4, SOX2, KLF4, and cMYC (OSKM) in mice leads to senescence and reprogramming, both coexisting in close proximity...
November 25, 2016: Science
https://www.readbyqxmd.com/read/27884210/characteristics-of-illegal-and-legal-cigarette-packs-sold-in-guatemala
#16
Rodrigo Arevalo, Juan E Corral, Diego Monzon, Mira Yoon, Joaquin Barnoya
BACKGROUND: Guatemala, as a party to the Framework Convention on Tobacco Control (FCTC), is required to regulate cigarette packaging and labeling and eliminate illicit tobacco trade. Current packaging and labeling characteristics (of legal and illegal cigarettes) and their compliance with the FCTC is unknown. METHODS: We sought to analyze package and label characteristics of illegal and legal cigarettes sold in Guatemala. We visited the 22 largest traditional markets in the country to purchase illegal cigarettes...
November 25, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27877238/sphingomyelin-liposomes-containing-porphyrin-phospholipid-for-irinotecan-chemophototherapy
#17
Kevin A Carter, Dandan Luo, Aida Razi, Jumin Geng, Shuai Shao, Joaquin Ortega, Jonathan F Lovell
Porphyrin-phospholipid (PoP) liposomes can entrap anti-cancer agents and release them in response to near infrared (NIR) light. Doxorubicin, when remotely loaded via an ammonium sulfate gradient at a high drug-to-lipid ratio, formed elongated crystals that altered liposome morphology and could not be loaded into liposomes with higher PoP content. On the other hand, irinotecan could also be remotely loaded but did not form large crystals and did not induce liposome elongation. The loading, stability, and NIR light-triggered release of irinotecan in PoP liposomes was altered by the types of lipids used and the presence of PEGylation...
2016: Theranostics
https://www.readbyqxmd.com/read/27875993/a-transcriptome-based-model-of-central-memory-cd4-t-cell-death-in-hiv-infection
#18
Gustavo Olvera-García, Tania Aguilar-García, Fany Gutiérrez-Jasso, Iván Imaz-Rosshandler, Claudia Rangel-Escareño, Lorena Orozco, Irma Aguilar-Delfín, Joel A Vázquez-Pérez, Joaquín Zúñiga, Santiago Pérez-Patrigeon, Enrique Espinosa
BACKGROUND: Human central memory CD4 T cells are characterized by their capacity of proliferation and differentiation into effector memory CD4 T cells. Homeostasis of central memory CD4 T cells is considered a key factor sustaining the asymptomatic stage of Human Immunodeficiency Virus type 1 (HIV-1) infection, while progression to acquired immunodeficiency syndrome is imputed to central memory CD4 T cells homeostatic failure. We investigated if central memory CD4 T cells from patients with HIV-1 infection have a gene expression profile impeding proliferation and survival, despite their activated state...
November 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27875103/diffusion-weighted-imaging-as-a-treatment-response-biomarker-for-evaluating-bone-metastases-in-prostate-cancer-a-pilot-study
#19
Raquel Perez-Lopez, Joaquin Mateo, Helen Mossop, Matthew D Blackledge, David J Collins, Mihaela Rata, Veronica A Morgan, Alison Macdonald, Shahneen Sandhu, David Lorente, Pasquale Rescigno, Zafeiris Zafeiriou, Diletta Bianchini, Nuria Porta, Emma Hall, Martin O Leach, Johann S de Bono, Dow-Mu Koh, Nina Tunariu
Purpose To determine the usefulness of whole-body diffusion-weighted imaging (DWI) to assess the response of bone metastases to treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). Materials and Methods A phase II prospective clinical trial of the poly-(adenosine diphosphate-ribose) polymerase inhibitor olaparib in mCRPC included a prospective magnetic resonance (MR) imaging substudy; the study was approved by the institutional research board, and written informed consent was obtained...
November 22, 2016: Radiology
https://www.readbyqxmd.com/read/27872841/novel-graphical-analyses-of-runs-of-homozygosity-among-species-and-livestock-breeds
#20
Laura Iacolina, Astrid V Stronen, Cino Pertoldi, Małgorzata Tokarska, Louise S Nørgaard, Joaquin Muñoz, Anders Kjærsgaard, Aritz Ruiz-Gonzalez, Stanisław Kamiński, Deirdre C Purfield
Runs of homozygosity (ROH), uninterrupted stretches of homozygous genotypes resulting from parents transmitting identical haplotypes to their offspring, have emerged as informative genome-wide estimates of autozygosity (inbreeding). We used genomic profiles based on 698 K single nucleotide polymorphisms (SNPs) from nine breeds of domestic cattle (Bos taurus) and the European bison (Bison bonasus) to investigate how ROH distributions can be compared within and among species. We focused on two length classes: 0...
2016: International Journal of Genomics
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