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https://www.readbyqxmd.com/read/28729277/draft-genome-sequence-of-salmonella-enterica-subsp-enterica-serovar-infantis-strain-spe101-isolated-from-a-chronic-human-infection
#1
Andrés Iriarte, Joaquín Giner-Lamia, Claudia Silva, Laura Betancor, Lizeth Astocondor, Juan J Cestero, Theresa Ochoa, Coralith García, José L Puente, José A Chabalgoity, Francisco García-Del Portillo
We report a 4.99-Mb draft genome sequence of Salmonella enterica subsp. enterica serovar Infantis strain SPE101, isolated from feces of a 5-month-old breast-fed female showing diarrhea associated with severe dehydration and malnutrition. The infection prolonged for 6 months despite antibiotic treatment.
July 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28726885/simulation-of-the-experimental-imaging-results-for-the-oh-chd3-reaction-with-a-simple-and-accurate-theoretical-approach
#2
Laurent Bonnet, Joaquin Espinosa-Garcia
The OH + CHD3 reaction is among the largest one ever studied at the high-resolution level permitted by imaging techniques [B. Zhang et al., J. Phys. Chem. A, 2005, 109, 8989]. This process involves eighteen configuration space coordinates, which are large enough to make exact quantum scattering calculations beyond reach. Moreover, freezing some degrees-of-freedom in order to render these calculations feasible may lead to unrealistic predictions. However, we have found it possible to reproduce for the first time the pair-correlated measurements of Zhang et al...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726560/bayesian-methods-for-addressing-long-standing-problems-in-associative-learning-the-case-of-pree
#3
Fernando Blanco, Joaquín Moris
Most associative models typically assume that learning can be understood as a gradual change in associative strength that captures the situation into one single parameter, or representational state. We will call this view single-state learning. However, there is ample evidence showing that under many circumstances different relationships that share features can be learned independently, and animals can quickly switch between expressing one or another. We will call this multiple-state learning. Theoretically, it is understudied because it needs a different data analysis approach from those usually employed...
July 20, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28724089/grower-analysis-of-organic-matter-amendments-in-california-orchards
#4
Sat Darshan S Khalsa, Patrick H Brown
Organic matter amendments supply crop nutrients and enhance soil health, yet information specific to orchards is lacking. A survey was conducted to analyze use of these materials by California almond [ (Mill.) D.A. Webb] growers. Significant differences were observed for benefits, concerns, and accessibility to manure and green waste sources and between users and nonusers. Use patterns were significantly influenced by heavy and light users, farm size, and geographic region. Enhanced soil biology was the main benefit attributed to organic matter amendments by both users and nonusers...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28723712/the-role-of-oncogenic-hpv-determination-for-diagnosis-of-high-grade-anal-intraepithelial-neoplasia-in-hiv-infected-msm
#5
Joaquin Burgos, J Hernández-Losa, S Landolfi, A Guelar, Mªc Dinares, J Villar, J Navarro, E Ribera, V Falcó, A Curran
OBJECTIVE: To assess the oncogenic human papillomavirus (HPV) determination and the co-testing HPV and anal cytology value to detect high-grade anal intraepithelial neoplasia (HGAIN) in a cohort of HIV-MSM. DESIGN AND METHODS: Prospective study of HIV-infected MSM who underwent screening for anal dysplasia. Screening program includes anal cytology, HPV testing, and high-resolution anoscopy (HRA) at each visit. Histological samples were obtained if suspicious lesions were revealed by HRA...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723506/biomarkers-for-metastatic-castration-resistant-prostate-cancer-mcrpc-yes-or-no-predictive-and-response-biomarkers-towards-precision-medicine-in-mcrpc
#6
Joaquin Mateo
Advances in drug development and molecular studies for castration-resistant prostate cancer (CRPC) render the possibility of more efficient and precise patient care through the use of predictive, response, and resistance biomarkers. Thorough scrutiny of assay validation and clinical qualification processes for biomarkers in development, ideally in parallel with clinical trials, is critical for the success of personalised medicine in CRPC management.
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28722546/the-role-of-recollection-and-familiarity-in-nondemented-parkinson-s-patients
#7
Alfonso Pitarque, Juan C Melendez, Alicia Sales, Encar Satorres, Joaquin Escudero, Salvador Algarabel
The aim of the current study was to examine if recollection and familiarity decline in nondemented Parkinson's patients. To do so we compared a sample of older people with Parkinson's disease (n = 32) to a control sample of healthy older people (n = 32) on an associative recognition task in which we manipulated the repetition of the pairs during the study phase (half of the pairs were presented once and half twice) to obtain corrected estimates of recollection, familiarity, and false recognition based on the logic of the process-dissociation procedure...
July 2017: Journal of General Psychology
https://www.readbyqxmd.com/read/28722472/1-benzenesulfonyl-1-5-dihydro-4-1-benzoxazepine-as-a-new-scaffold-for-the-design-of-antitumor-compounds
#8
Olga Cruz-López, Alberto Ramírez, Saúl A Navarro, María A García, Juan A Marchal, Joaquín M Campos, Ana Conejo-García
AIM: Bozepinib is a potent and selective anticancer compound which chemical structure is made up of a benzofused seven-membered ring and a purine moiety. We previously demonstrated that the purine fragment does not exert antiproliferative effect per se. METHODOLOGY: A series of 1-(benzenesulfonyl)-4,1-benzoxazepine derivatives were synthesized in order to study the influence of the benzofused seven-membered ring in the biological activity of bozepinib by means of antiproliferative, cell cycle and apoptosis studies...
July 19, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28722015/trpv1-regulates-excitatory-innervation-of-olm-neurons-in-the-hippocampus
#9
Joaquin I Hurtado-Zavala, Binu Ramachandran, Saheeb Ahmed, Rashi Halder, Christiane Bolleyer, Ankit Awasthi, Markus A Stahlberg, Robin J Wagener, Kristin Anderson, Ryan M Drenan, Henry A Lester, Julie M Miwa, Jochen F Staiger, Andre Fischer, Camin Dean
TRPV1 is an ion channel activated by heat and pungent agents including capsaicin, and has been extensively studied in nociception of sensory neurons. However, the location and function of TRPV1 in the hippocampus is debated. We found that TRPV1 is expressed in oriens-lacunosum-moleculare (OLM) interneurons in the hippocampus, and promotes excitatory innervation. TRPV1 knockout mice have reduced glutamatergic innervation of OLM neurons. When activated by capsaicin, TRPV1 recruits more glutamatergic, but not GABAergic, terminals to OLM neurons in vitro...
July 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28719928/endoscopy-guided-surgery-of-an-atrio-esophageal-fistula-after-failure-of-self-expandable-metal-stents
#10
Ignacio Couto-Worner, Pedro A Alonso-Aguirre, Emilio Estévez-Prieto, Benito González-Conde, Carlos Velasco-García, José Joaquín Cuenca-Castillo, Salvador Fojón-Polanco
No abstract text is available yet for this article.
July 18, 2017: Endoscopy
https://www.readbyqxmd.com/read/28719260/symptomatic-falciparum-malaria-after-living-in-a-nonendemic-area-for-10-years-recrudescence-or-indigenous-transmission
#11
Joaquín Salas-Coronas, Manuel Jesús Soriano-Pérez, Ana B Lozano-Serrano, Rosario Pérez-Moyano, Carmen Porrino-Herrera, María Teresa Cabezas-Fernández
AbstractWe report the case of a patient from Mali who, after 10 years of living in Spain, presented with symptomatic Plasmodium falciparum malaria without having visited an endemic area during that time. We cannot completely rule out the possibility of indigenous transmission, but this case most likely represents recrudescence of an infection acquired over 10 years earlier.
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28716979/blood-biomarkers-for-the-early-diagnosis-of-stroke-the-stroke-chip-study
#12
Alejandro Bustamante, Elena López-Cancio, Sara Pich, Anna Penalba, Dolors Giralt, Teresa García-Berrocoso, Carles Ferrer-Costa, Teresa Gasull, María Hernández-Pérez, Mónica Millan, Marta Rubiera, Pedro Cardona, Luis Cano, Helena Quesada, Mikel Terceño, Yolanda Silva, Mar Castellanos, Moisés Garces, Silvia Reverté, Xavier Ustrell, Rafael Marés, Joan Josep Baiges, Joaquín Serena, Francisco Rubio, Eduardo Salas, Antoni Dávalos, Joan Montaner
BACKGROUND AND PURPOSE: Stroke diagnosis could be challenging in the acute phase. We aimed to develop a blood-based diagnostic tool to differentiate between real strokes and stroke mimics and between ischemic and hemorrhagic strokes in the hyperacute phase. METHODS: The Stroke-Chip was a prospective, observational, multicenter study, conducted at 6 Stroke Centers in Catalonia. Consecutive patients with suspected stroke were enrolled within the first 6 hours after symptom onset, and blood samples were drawn immediately after admission...
July 17, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28716956/a-comparison-of-behavioral-and-pharmacological-interventions-to-attenuate-reactivated-fear-memories
#13
Roque I Ferrer Monti, Joaquín M Alfei, Matías Mugnaini, Adrián M Bueno, Tom Beckers, Gonzalo P Urcelay, Victor A Molina
Two experiments using rats in a contextual fear memory preparation compared two approaches to reduce conditioned fear: (1) pharmacological reconsolidation blockade and (2) reactivation-plus-extinction training. In Experiment 1, we explored different combinations of reactivation-plus-extinction parameters to reduce conditioned fear and attenuate reacquisition. In Experiment 2, memory reactivation was followed by extinction training or administration of midazolam (MDZ) (vs. vehicle) to reduce conditioned fear and attenuate spontaneous recovery...
August 2017: Learning & Memory
https://www.readbyqxmd.com/read/28714736/does-music-therapy-improve-anxiety-and-depression-in-alzheimer-s-patients
#14
José Enrique de la Rubia Ortí, María Pilar García-Pardo, Carmen Cabañés Iranzo, José Joaquin Cerón Madrigal, Sandra Sancho Castillo, Mariano Julián Rochina, Vicente Javier Prado Gascó
OBJECTIVE: To evaluate the effectiveness of the implementation of a short protocol of music therapy as a tool to reduce stress and improve the emotional state in patients with mild Alzheimer's disease. METHODS: A sample of 25 patients with mild Alzheimer's received therapy based on the application of a music therapy session lasting 60 min. Before and after the therapy, patient saliva was collected to quantify the level of salivary cortisol using the Enzyme-Linked ImmunoSorbent Assay (ELISA) immunoassay technique and a questionnaire was completed to measure anxiety and depression (Hospital Anxiety and Depression Scale)...
July 17, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28714069/discriminant-biomarkers-of-acute-respiratory-distress-syndrome-associated-to-h1n1-influenza-identified-by-metabolomics-hplc-qtof-ms-ms-platform
#15
Alessia Ferrarini, Laura Righetti, Ma Paz Martínez, Mariano Fernández, Annalaura Mastrangelo, Juan P Horcajada, Antoni Betbesé, Andrés Esteban, Jordi Ordóñez, Joaquín de Gea, Jesús Ruiz Cabello, Federica Pellati, José A Lorente, Nicolás Nin, Francisco J Rupérez
Acute Respiratory Distress Syndrome (ARDS) is a serious complication of influenza A (H1N1) virus infection. Its pathogenesis is unknown, and biomarkers are lacking. Untargeted metabolomics allows the analysis of the whole metabolome in a biological compartment, identifying patterns associated with specific conditions. We hypothesized that LC-MS could help identify discriminant metabolites able to define the metabolic alterations occurring in patients with influenza A (H1N1) virus infection that developed ARDS...
July 17, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28709648/deficiency-in-cold-inducible-rna-binding-protein-attenuates-acute-respiratory-distress-syndrome-induced-by-intestinal-ischemia-reperfusion
#16
Cindy Cen, Joseph McGinn, Monowar Aziz, Weng-Lang Yang, Joaquin Cagliani, Jeffrey M Nicastro, Gene F Coppa, Ping Wang
BACKGROUND: Intestinal ischemia-reperfusion can occur in shock and mesenteric occlusive diseases, causing significant morbidity and mortality. Aside from local injury, intestinal ischemia-reperfusion can result in remote organ damage, particularly in the lungs. Cold-inducible RNA-binding protein (CIRP) was identified as a novel inflammatory mediator. We hypothesized that a deficiency in CIRP would protect the lungs during intestinal ischemia-reperfusion injury. METHODS: Intestinal ischemia was induced in adult male C57BL/6 wild-type and CIRP knock-out (CIRP(-/-)) mice via clamping of the superior mesenteric artery for 60 minutes...
July 11, 2017: Surgery
https://www.readbyqxmd.com/read/28708616/monitoring-accumulation-sediment-characteristics-in-full-scale-sewer-physical-model-with-urban-wastewater
#17
Manuel Regueiro-Picallo, Juan Naves, Jose Anta, Joaquín Suárez, Jerónimo Puertas
A series of experiments were carried out with real wastewater in a pilot flume located at A Coruña wastewater treatment plant (WWTP) (Spain). A full scale model was developed to test a circular (300 mm inner diameter) and an equivalent area egg-shaped plastic pipe under controlled experimental conditions (pipe slope 2-5‰, averaged discharge Q = 4 L/s). Velocity profiles and sediment accumulation in the pipe invert was daily measured. Within the 7-11 days, the average sediment accumulation rate found in the circular pipe was between 1...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28707440/everolimus-eluting-bioresorbable-vascular-scaffolds-can-we-absorb-the-risk-in-complex-pci
#18
EDITORIAL
Firas Zahr, Joaquin E Cigarroa
BVS, as compared with DES, have higher stent thrombosis (ST) rates. BVS may prove reasonable in patients with complex anatomy. Future trials will be necessary to guide clinicians regarding whether BVS are equivalent to DES in patients with noncomplex or complex coronary anatomy.
July 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28704552/ptch1-is-a-reliable-marker-for-predicting-imatinib-response-in-chronic-myeloid-leukemia-patients-in-chronic-phase
#19
Juan M Alonso-Dominguez, Luis Felipe Casado, Eduardo Anguita, Maria Teresa Gomez-Casares, Ismael Buño, Francisca Ferrer-Marín, Alicia Arenas, Rafael Del Orbe, Rosa Ayala, Pilar Llamas, Rocio N Salgado, Santiago Osorio, Pedro Sanchez-Godoy, Carmen Burgaleta, Ignacio Mahíllo-Fernández, Valentin Garcia-Gutierrez, Juan Luis Steegmann, Joaquín Martinez-Lopez
Patched homolog 1 gene (PTCH1) expression and the ratio of PTCH1 to Smoothened (SMO) expression have been proposed as prognostic markers of the response of chronic myeloid leukemia (CML) patients to imatinib. We compared these measurements in a realistic cohort of 101 patients with CML in chronic phase (CP) using a simplified qPCR method, and confirmed the prognostic power of each in a competing risk analysis. Gene expression levels were measured in peripheral blood samples at diagnosis. The PTCH1/SMO ratio did not improve PTCH1 prognostic power (area under the receiver operating characteristic curve 0...
2017: PloS One
https://www.readbyqxmd.com/read/28699147/what-are-the-complications-survival-and-outcomes-after-revision-to-reverse-shoulder-arthroplasty-in-patients-older-than-80-years
#20
Eduard Alentorn-Geli, Nicholas J Clark, Andrew T Assenmacher, Brian T Samuelsen, Joaquín Sánchez-Sotelo, Robert H Cofield, John W Sperling
BACKGROUND: By the time patients with a failed shoulder arthroplasty require revision surgery, a substantial number are older than 80 years. The risk of complications of revision arthroplasty in this elderly population is largely unknown and needs to be considered when contemplating whether these patients are too frail for revision surgery. QUESTIONS/PURPOSES: (1) What are the 90-day medical and surgical complications after revision to reverse shoulder arthroplasty (RSA) in patients older than 80 years? (2) What are the 2- and 5-year survival rates after revision? (3) Was there an improvement in pain at rest or with activity, range of motion (ROM), and strength after revision surgery? METHODS: Between 2004 and 2013, 38 patients who were older than 80 years (84 ± 3 years) underwent revision surgery to a RSA...
July 11, 2017: Clinical Orthopaedics and related Research
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