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Joaquín Cabezas, Trinidad Sánchez-Rodríguez, Juan Antonio Gómez-Galán, Héctor Cifuentes, Ramón González Carvajal
This work presents the design, construction and testing of a new embedded sensor system for monitoring concrete curing. A specific mote has been implemented to withstand the aggressive environment without affecting the measured variables. The system also includes a real-time monitoring application operating from a remote computer placed in a central location. The testing was done in two phases: the first in the laboratory, to validate the functional requirements of the developed devices; and the second on civil works to evaluate the functional features of the devices, such as range, robustness and flexibility...
March 15, 2018: Sensors
Evgeny J Chumin, Joaquín Goñi, Meredith E Halcomb, Timothy C Durazzo, Mario Džemidžić, Karmen K Yoder
BACKGROUND: Diffusion weighted imaging (DWI) has been widely used to investigate the integrity of white matter (WM; indexed by fractional anisotropy, FA) in alcohol dependence and cigarette smoking. These disorders are highly comorbid, yet cigarette use has often not been adequately controlled in neuroimaging studies of alcohol dependent populations. In addition, information on white matter deficits in currently drinking, nontreatment-seeking (NTS) individuals with alcohol dependence is limited...
March 15, 2018: Alcoholism, Clinical and Experimental Research
Beatriz Bernardo-Maestro, Elisa Garrido-Martín, Fernando López-Arbeloa, Joaquín Pérez-Pariente, Luis Gómez-Hortigüela
In an attempt to promote the crystallization of chiral inorganic frameworks, we explore the ability of chiral (1R,2S)-ephedrine and its diastereoisomer (1S,2S)-pseudoephedrine to act as organic building blocks for the crystallization of hybrid organo-inorganic aluminophosphate frameworks in the presence of fluoride. These molecules were selected because of their particular molecular asymmetric structure, which enables a rich supramolecular chemistry and a potential chiral recognition phenomenon during crystallization...
March 15, 2018: Physical Chemistry Chemical Physics: PCCP
Lucía Fernández, Alejandra Leivas, Jaime Valentín, Adela Escudero, Dolores Corral, Raquel de Paz, Maria Vela, David Bueno, Rebeca Rodríguez, Juan Manuel Torres, Mariana Díaz-Almirón, Eduardo López-Collazo, Joaquin Martinez-Lopez, Antonio Pérez-Martínez
BACKGROUND: Cancer immunotherapy involving natural killer (NK) cells has gained interest. Here we report two methods to obtain interleukin (IL)-15-activated NK cells for clinical use. STUDY DESIGN AND METHODS: IL-15-activated NK cell products were obtained after 1) enrichment from healthy haploidentical donors' peripheral blood mononuclear cells (PBMNCs) collected by nonmobilized apheresis by a two-step magnetic procedure, depletion of CD3+ cells followed by selection of CD56+ cells and ex vivo overnight stimulation with IL-15 (NKIL15); and 2) expansion using the K562-mb15-41BBL cell line (NKAE), from autologous PBMNCs from patients with multiple myeloma or expansion from healthy haploidentical PBMNCs obtained from whole blood using the same previous cell line...
March 14, 2018: Transfusion
Joaquin Escribano, Natalia Ferré, Mariona Gispert-Llaurado, Veronica Luque, Carmen Rubio-Torrents, Marta Zaragoza-Jordana, Isabel Polanco, Francisco M Codoñer, Empar Chenoll, Mireia Morera, Jose Antonio Moreno Muñoz, Montserrat Rivero, Ricardo Closa-Monasterolo
BACKGROUND: Intestinal microbiota of breast-fed infants is plenty of beneficial bifidobacteria. We aimed to determine whether an infant formula supplemented with probiotic Bifidobacterium longum subsp. infantis CECT7210 (B. infantis IM1®) is effective at reducing diarrhoea incidence in healthy term infants. METHODS: Double-blinded, randomized, multicentre, controlled clinical trial, where formula-fed infants (<3 months) received an infant formula supplemented (Probiotic) or not (Control) with 107 cfu/g of B...
March 14, 2018: Pediatric Research
Lars Borchardt, Mirian Elizabeth Casco, Joaquin Silvestre-Albero
Methane hydrate inheres the great potential to be a nature-inspired alternative for chemical energy storage, since it allows to store large amounts of methane in a dense solid phase. The embedment of methane hydrate in the confined environment of porous materials can be capitalized for potential applications as its physico-chemical properties such as the formation kinetics or pressure and temperature stability are significantly changed as compared to the bulk system. We review this topic from a materials scientific perspective by considering porous carbons, silica, clays, zeolites, and polymers as host structure for methane hydrate formation...
March 14, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Laura Burgueño Torres, María Rosa Mourelle Martínez, Montserrat Diéguez Pérez, Joaquín M de Nova García
AIM: To analyse differences in the eruption of primary teeth between both sexes. MATERIALS AND METHODS: A cross-sectional study was performed in a sample of 1250 children aged between 3 and 42 months. The clinical emergence of teeth was taken to estimate average ages for primary teeth eruption. The t-test was used to analyse gender and arch differences. RESULTS: Eruption of primary teeth began at the same time in girls as in boys; although the eruptive process was longer in girls...
March 14, 2018: Acta Odontologica Scandinavica
Joaquín M González-Cabrera, María Fernández-Prada, Concepción Iribar, Rogelio Molina-Ruano, María Salinero-Bachiller, José M Peinado
The objectives of this longitudinal study were to compare salivary cortisol release patterns in medical residents and their self-perceived anxiety levels between a regular working day and a day when on call in the emergency department (ED-duty day) and to determine any differences in cortisol release pattern as a function of years of residency or sex. The study included 35 residents (physicians-in-training) of the Granada University Hospital, Granada, Spain. Acute stress was measured on a regular working day and an ED-duty day, evaluating anxiety-state with the Spanish version of the State-Trait Anxiety Inventory...
March 13, 2018: International Journal of Environmental Research and Public Health
Brent E Fitzwalter, Christina G Towers, Kelly D Sullivan, Zdenek Andrysik, Maria Hoh, Michael Ludwig, Jim O'Prey, Kevin M Ryan, Joaquin M Espinosa, Michael J Morgan, Andrew Thorburn
Macroautophagy (autophagy) is intimately linked with cell death and allows cells to evade apoptosis. This has prompted clinical trials to combine autophagy inhibitors with other drugs with the aim of increasing the likelihood of cancer cells dying. However, the molecular basis for such effects is unknown. Here, we describe a transcriptional mechanism that connects autophagy to apoptosis. The autophagy-regulating transcription factor, FOXO3a, is itself turned over by basal autophagy creating a potential feedback loop...
March 12, 2018: Developmental Cell
Jatish Kumar, Hasier Eraña, Elena López-Martínez, Nathalie Claes, Víctor F Martín, Diego M Solís, Sara Bals, Aitziber L Cortajarena, Joaquín Castilla, Luis M Liz-Marzán
Amyloid fibrils, which are closely associated with various neurodegenerative diseases, are the final products in many protein aggregation pathways. The identification of fibrils at low concentration is, therefore, pivotal in disease diagnosis and development of therapeutic strategies. We report a methodology for the specific identification of amyloid fibrils using chiroptical effects in plasmonic nanoparticles. The formation of amyloid fibrils based on α-synuclein was probed using gold nanorods, which showed no apparent interaction with monomeric proteins but effective adsorption onto fibril structures via noncovalent interactions...
March 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
Marianne Kaiser, Magdalena Jacobson, Pia Haubro Andersen, Poul Bækbo, José Joaquin Cerón, Jan Dahl, Damián Escribano, Stine Jacobsen
BACKGROUND: The pathogenesis of postpartum dysgalactia syndrome (PDS) in sows is not fully elucidated and affected sows often present vague clinical signs. Accurate and timely diagnosis is difficult, and PDS is often recognized with a delay once piglets begin to starve. Increased rectal temperature of the sow is an important diagnostic parameter, but it may also be influenced by a number of other parameters and is thus difficult to interpret. Inflammatory markers may be important adjuncts to the clinical assessment of sows with PDS, but such markers have only been studied to a limited extent...
March 12, 2018: BMC Veterinary Research
Ana Valero-Jiménez, Joaquín Zúñiga, José Cisneros, Carina Becerril, Alfonso Salgado, Marco Checa, Ivette Buendía-Roldán, Criselda Mendoza-Milla, Miguel Gaxiola, Annie Pardo, Moisés Selman
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized by epithelial cell activation, expansion of the fibroblast population and excessive extracellular matrix accumulation. The mechanisms are incompletely understood but evidence indicates that the deregulation of several proteases contributes to its pathogenesis. Transmembrane protease serine 4 (TMPRSS4) is a novel type II transmembrane serine protease that may promote migration and facilitate epithelial to mesenchymal transition (EMT), two critical processes in the pathogenesis of IPF...
2018: PloS One
Carmen Gonzalez-Hidalgo, Joaquin De Haro, Silvia Bleda, Cristina Cañibano, Ignacio Michel, Francisco Acin
NLRP1 and NLRP3 inflammasomes might differentially mediate the chronic inflammatory response in abdominal aortic aneurysm (AAA) and aortic occlusive disease (AOD). We measure differential relative gene expression of NLRP1 and NLRP3 inflammasomes in aortic tissues from 30 patients undergoing AAA open repair compared to aortic biopsies from 30 patients undergoing surgery to treat AOD. Aortic wall samples from autopsy without aortic disease were used as controls. NLRP3 was overexpressed in patients with AAA and AOD (RQ 1...
April 2018: Therapeutic Advances in Cardiovascular Disease
Federico Argüelles Arias, Joaquín Hinojosa Del Val, Isabel Vera Mendoza
In 2013, the European Medicines Agency (EMA) approved the biosimilar infliximab (CT-P13) for the full range of indications of the originator product, based on data from two trials conducted in rheumatoid arthritis and ankylosing spondylitis. The same year, our Society published a position statement that was later reviewed.
March 12, 2018: Revista Española de Enfermedades Digestivas
Joaquín Cicotello, Irma V Wolf, Luisa D'Angelo, Daniela M Guglielmotti, Andrea Quiberoni, Viviana B Suárez
The ability of twelve strains belonging to three Leuconostoc species (Leuconostoc mesenteroides, Leuconostoc lactis and Leuconostoc pseudomesenteroides) to grow under diverse sub-lethal technological stress conditions (cold, acidic, alkaline and osmotic) was evaluated in MRS broth. Two strains, Leuconostoc lactis Ln N6 and Leuconostoc mesenteroides Ln MB7, were selected based on their growth under sub-lethal conditions, and volatile profiles in RSM (reconstituted skim milk) at optimal and under stress conditions were analyzed...
August 2018: Food Microbiology
María Jesús García-Murria, Hemanth P K Sudhani, Julia Marín-Navarro, Manuel M Sánchez Del Pino, Joaquín Moreno
Oxidation of the cysteines from ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO) leads to inactivation and promotes structural changes that increase the proteolytic sensitivity and membrane association propensity related to its catabolism. To uncover the individual role of the different cysteines, the sequential order of modification under increasing oxidative conditions was determined using chemical labeling and mass spectrometry. Besides, site-directed RubisCO mutants were obtained in Chlamydomonas reinhardtii replacing single conserved cysteines (Cys84, Cys172, Cys192, Cys247, Cys284, Cys427, Cys459 from the large and sCys41, sCys83 from the small subunit) and the redox properties of the mutant enzymes were determined...
March 10, 2018: Photosynthesis Research
Joaquin G Cigarroa, Steven R Bailey
No abstract text is available yet for this article.
March 10, 2018: Journal of the American Heart Association
Joaquín Antonio González, Jonathan Germán Bafico, María Emilia Villanueva, Sergio Alejandro Giorgieri, Guillermo Javier Copello
A novel nanostructured material was successfully developed by combining a chitin matrix with graphene oxide nanosheets (Chi:nGO) and then used for the continuous flow adsorption of ciprofloxacin. The spectroscopic characterization indicated that none covalent interaction between both components would be occurring and the introduction of nGO did not interfere in chitin nanostructure rearrangement during gelling and later drying. SEM images and Mercury Intrusion Porosimetry results showed a wide pore size distribution ranging from nano to micrometers...
May 15, 2018: Carbohydrate Polymers
Mark Golberg, Joaquin Ruiz-Rivas, Sagi Polani, Yevgeny Beiderman, Zeev Zalevsky
Blood pressure (BP) is usually measured either invasively, by an intra-arterial catheter, or noninvasively, by a cuff-based sphygmomanometer. While the invasive method is continuous and more accurate, it has the risk of infection and generally is not comfortable for the patient. On the other hand, the cuff-based measurement is safer but less reliable and infrequent. Therefore, a reliable continuous noninvasive BP measurement is highly desirable. In this work, we propose a remote optical system, based on temporal analysis of secondary reflected speckle patterns, for computing a subject's pulse transit time (PTT)...
March 1, 2018: Applied Optics
Joaquín García-Gómez, Roberto Gil-Pita, Manuel Rosa-Zurera, Antonio Romero-Camacho, Jesús Antonio Jiménez-Garrido, Víctor García-Benavides
Pipeline inspection is a topic of particular interest to the companies. Especially important is the defect sizing, which allows them to avoid subsequent costly repairs in their equipment. A solution for this issue is using ultrasonic waves sensed through Electro-Magnetic Acoustic Transducer (EMAT) actuators. The main advantage of this technology is the absence of the need to have direct contact with the surface of the material under investigation, which must be a conductive one. Specifically interesting is the meander-line-coil based Lamb wave generation, since the directivity of the waves allows a study based in the circumferential wrap-around received signal...
March 7, 2018: Sensors
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