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https://www.readbyqxmd.com/read/29143691/health-claims-and-product-endorsements-on-child-oriented-beverages-in-guatemala
#1
Andrew Perry, Violeta Chacon, Joaquin Barnoya
OBJECTIVE: We sought to describe front-of-package marketing strategies and nutritional quality of child-oriented beverages in Guatemala. DESIGN: We purchased all child-oriented ready-to-drink fruit drinks, milks and carbonated beverages in three convenience stores and one supermarket in Guatemala City. Front-of-package marketing was defined as the presence of spokes-characters, cartoons, celebrities, or health-related images, words, claims or endorsements on beverage packaging...
November 16, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29143686/acute-phase-proteins-and-markers-of-oxidative-stress-to-assess-the-severity-of-the-pulmonary-hypertension-in-heartworm-infected-dogs
#2
Elena Carretón, José Joaquín Cerón, Silvia Martínez-Subiela, Asta Tvarijonaviciute, Alicia Caro-Vadillo, José Alberto Montoya-Alonso
BACKGROUND: Canine heartworm infection is characterized by pulmonary endarteritis and pulmonary hypertension (PH). The aim of the present study was to evaluate the relationship between PH with the concentrations of different positive (C-reactive protein [CRP] and haptoglobin [Hp]) and negative (albumin and paraoxonase-1 [PON-1]) acute phase proteins (APP), as well as the oxidative stress, by measuring glutathione peroxidase (GPx) and total antioxidant capacity (TAC) in 27 heartworm-infected dogs on Day 0 (diagnosis) and Day 120 (1 month after the last adulticide injection)...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143597/genotypic-and-phenotypic-features-of-all-spanish-patients-with-mcardle-disease-a-2016-update
#3
Alfredo Santalla, Gisela Nogales-Gadea, Alberto Blázquez Encinar, Irene Vieitez, Adrian González-Quintana, Pablo Serrano-Lorenzo, Inés García Consuegra, Sara Asensio, Alfonsina Ballester-Lopez, Guillem Pintos-Morell, Jaume Coll-Cantí, Helios Pareja-Galeano, Jorge Díez-Bermejo, Margarita Pérez, Antoni L Andreu, Tomàs Pinós, Joaquín Arenas, Miguel A Martín, Alejandro Lucia
BACKGROUND: We recently described the genotype/phenotype features of all Spanish patients diagnosed with McArdle disease as of January 2011 (n = 239, prevalence of ~1/167,000) (J Neurol Neurosurg Psychiatry 2012;83:322-8). Several caveats were however identified suggesting that the prevalence of the disease is actually higher. METHODS: We have now updated main genotype/phenotype data, as well as potential associations within/between them, of all Spanish individuals currently diagnosed with McArdle disease (December 2016)...
November 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29142317/the-maternal-genetic-make-up-of-the-iberian-peninsula-between-the-neolithic-and-the-early-bronze-age
#4
Anna Szécsényi-Nagy, Christina Roth, Guido Brandt, Cristina Rihuete-Herrada, Cristina Tejedor-Rodríguez, Petra Held, Íñigo García-Martínez-de-Lagrán, Héctor Arcusa Magallón, Stephanie Zesch, Corina Knipper, Eszter Bánffy, Susanne Friederich, Harald Meller, Primitiva Bueno Ramírez, Rosa Barroso Bermejo, Rodrigo de Balbín Behrmann, Ana M Herrero-Corral, Raúl Flores Fernández, Carmen Alonso Fernández, Javier Jiménez Echevarria, Laura Rindlisbacher, Camila Oliart, María-Inés Fregeiro, Ignacio Soriano, Oriol Vicente, Rafael Micó, Vicente Lull, Jorge Soler Díaz, Juan Antonio López Padilla, Consuelo Roca de Togores Muñoz, Mauro S Hernández Pérez, Francisco Javier Jover Maestre, Joaquín Lomba Maurandi, Azucena Avilés Fernández, Katina T Lillios, Ana Maria Silva, Miguel Magalhães Ramalho, Luiz Miguel Oosterbeek, Claudia Cunha, Anna J Waterman, Jordi Roig Buxó, Andrés Martínez, Juana Ponce Martínez, Mark Hunt Ortiz, Juan Carlos Mejías-García, Juan Carlos Pecero Espín, Rosario Cruz-Auñón Briones, Tiago Tomé, Eduardo Carmona Ballestero, João Luís Cardoso, Ana Cristina Araújo, Corina Liesau von Lettow-Vorbeck, Concepción Blasco Bosqued, Patricia Ríos Mendoza, Ana Pujante, José I Royo-Guillén, Marco Aurelio Esquembre Beviá, Victor Manuel Dos Santos Goncalves, Rui Parreira, Elena Morán Hernández, Elena Méndez Izquierdo, Jorge Vega Y Miguel, Roberto Menduiña García, Victoria Martínez Calvo, Oscar López Jiménez, Johannes Krause, Sandra L Pichler, Rafael Garrido-Pena, Michael Kunst, Roberto Risch, Manuel A Rojo-Guerra, Wolfgang Haak, Kurt W Alt
Agriculture first reached the Iberian Peninsula around 5700 BCE. However, little is known about the genetic structure and changes of prehistoric populations in different geographic areas of Iberia. In our study, we focus on the maternal genetic makeup of the Neolithic (~ 5500-3000 BCE), Chalcolithic (~ 3000-2200 BCE) and Early Bronze Age (~ 2200-1500 BCE). We report ancient mitochondrial DNA results of 213 individuals (151 HVS-I sequences) from the northeast, central, southeast and southwest regions and thus on the largest archaeogenetic dataset from the Peninsula to date...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141963/current-and-new-challenges-in-occupational-lung-diseases
#5
REVIEW
Sara De Matteis, Dick Heederik, Alex Burdorf, Claudio Colosio, Paul Cullinan, Paul K Henneberger, Ann Olsson, Anne Raynal, Jos Rooijackers, Tiina Santonen, Joaquin Sastre, Vivi Schlünssen, Martie van Tongeren, Torben Sigsgaard
Occupational lung diseases are an important public health issue and are avoidable through preventive interventions in the workplace. Up-to-date knowledge about changes in exposure to occupational hazards as a result of technological and industrial developments is essential to the design and implementation of efficient and effective workplace preventive measures. New occupational agents with unknown respiratory health effects are constantly introduced to the market and require periodic health surveillance among exposed workers to detect early signs of adverse respiratory effects...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29138301/genomic-variation-and-evolution-of-vibrio-parahaemolyticus-st36-over-the-course-of-a-transcontinental-epidemic-expansion
#6
Jaime Martinez-Urtaza, Ronny van Aerle, Michel Abanto, Julie Haendiges, Robert A Myers, Joaquin Trinanes, Craig Baker-Austin, Narjol Gonzalez-Escalona
Vibrio parahaemolyticus is the leading cause of seafood-related infections with illnesses undergoing a geographic expansion. In this process of expansion, the most fundamental change has been the transition from infections caused by local strains to the surge of pandemic clonal types. Pandemic clone sequence type 3 (ST3) was the only example of transcontinental spreading until 2012, when ST36 was detected outside the region where it is endemic in the U.S. Pacific Northwest causing infections along the U.S. northeast coast and Spain...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29136505/inhibition-of-trf1-telomere-protein-impairs-tumor-initiation-and-progression-in-glioblastoma-mouse-models-and-patient-derived-xenografts
#7
Leire Bejarano, Alberto J Schuhmacher, Marinela Méndez, Diego Megías, Carmen Blanco-Aparicio, Sonia Martínez, Joaquín Pastor, Massimo Squatrito, Maria A Blasco
Glioblastoma multiforme (GBM) is a deadly and common brain tumor. Poor prognosis is linked to high proliferation and cell heterogeneity, including glioma stem cells (GSCs). Telomere genes are frequently mutated. The telomere binding protein TRF1 is essential for telomere protection, and for adult and pluripotent stem cells. Here, we find TRF1 upregulation in mouse and human GBM. Brain-specific Trf1 genetic deletion in GBM mouse models inhibited GBM initiation and progression, increasing survival. Trf1 deletion increased telomeric DNA damage and reduced proliferation and stemness...
November 13, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29131852/unraveling-the-key-to-the-resistance-of-canids-to-prion-diseases
#8
Natalia Fernández-Borges, Beatriz Parra, Enric Vidal, Hasier Eraña, Manuel A Sánchez-Martín, Jorge de Castro, Saioa R Elezgarai, Martí Pumarola, Tomás Mayoral, Joaquín Castilla
One of the characteristics of prions is their ability to infect some species but not others and prion resistant species have been of special interest because of their potential in deciphering the determinants for susceptibility. Previously, we developed different in vitro and in vivo models to assess the susceptibility of species that were erroneously considered resistant to prion infection, such as members of the Leporidae and Equidae families. Here we undertake in vitro and in vivo approaches to understand the unresolved low prion susceptibility of canids...
November 13, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29131657/variability-of-the-dynamic-stiffness-of-foot-joints-effect-of-gait-velocity-variation
#9
Enrique Sanchis, Joaquín Luis Sancho-Bru, Alba Roda-Sales, Javier Pascual Huerta
BACKGROUND: Comparison of dynamic stiffness of foot joints was previously proposed to investigate pathological situations with changes in the properties of muscle and passive structures. Samples must be controlled to reduce the variability within groups being compared, which may arise from different sources, such as gait speed or foot posture index (FPI). METHODS: In this work, variability in the measurement of the dynamic stiffness of ankle, midtarsal and metatarsophalangeal joints was studied in a controlled sample of healthy adult male subjects with normal FPI, and the effect of gait speed was analyzed...
November 13, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29128497/replacement-of-oxidizable-residues-predicted-by-qm-mm-simulation-of-a-fungal-laccase-generates-variants-with-higher-operational-stability
#10
Mayra Avelar, Nina Pastor, Joaquin Ramirez-Ramirez, Marcela Ayala
In this work, we sought to obtain a more stable laccase with higher operational stability for the oxidation of phenols. During this reaction, phenoxy free radicals are produced that gradually inactivate the enzyme; the inactivation rate depends on the phenol chemical nature. In order to predict residues prone to oxidize within the active site, we simulated activated states of the catalytic region of a fungal laccase using QM-MM tools (Quantum Mechanics-Molecular Mechanics). After simulating the electron distribution in both the basal and activated state (plus or minus one electron) of several conformations of Coriolopsis gallica laccase, residues that could be susceptible to oxidation were identified, according to the values of spin density obtained from calculations...
October 12, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29125602/mechanisms-of-transcriptional-regulation-by-p53
#11
REVIEW
Kelly D Sullivan, Matthew D Galbraith, Zdenek Andrysik, Joaquin M Espinosa
p53 is a transcription factor that suppresses tumor growth through regulation of dozens of target genes with diverse biological functions. The activity of this master transcription factor is inactivated in nearly all tumors, either by mutations in the TP53 locus or by oncogenic events that decrease the activity of the wild-type protein, such as overexpression of the p53 repressor MDM2. However, despite decades of intensive research, our collective understanding of the p53 signaling cascade remains incomplete...
November 10, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29119978/demixing-and-ordering-in-ni-ti-zr-sb-sn-half-heusler-materials
#12
Joaquin Miranda Mena, Thomas Gruhn
We employed density functional theory, Monte Carlo simulations and a mean field model to study phase separation in thermoelectric Ni(Ti,Zr)(Sb,Sn) half-Heusler materials, simultaneously alloyed in the (Ti,Zr)- and (Sb,Sn) sublattices. We found that the material shows demixing and ordering phenomena as the temperature is lowered. Below a critical temperature, which depends on the overall stoichiometry, demixing occurs within the sublattices. Typically, a strong demixing in the (Ti,Zr) sublattice is accompanied by a weaker demixing in the (Sb,Sn) sublattice stoichiometry...
November 9, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29117556/cdk8-kinase-activity-promotes-glycolysis
#13
Matthew D Galbraith, Zdenek Andrysik, Ahwan Pandey, Maria Hoh, Elizabeth A Bonner, Amanda A Hill, Kelly D Sullivan, Joaquín M Espinosa
Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancerous tissues. Despite its importance in cancer development, our understanding of mechanisms driving this form of metabolic reprogramming is incomplete. We report here an analysis of colorectal cancer cells engineered to carry a single point mutation in the active site of the Mediator-associated kinase CDK8, creating hypomorphic alleles sensitive to bulky ATP analogs. Transcriptome analysis revealed that CDK8 kinase activity is required for the expression of many components of the glycolytic cascade...
November 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/29116785/a-positive-allosteric-modulator-of-the-serotonin-5-ht2c-receptor-for-obesity
#14
Javier García Cárceles, Juan M Decara, Henar Vázquez-Villa, Ramón Rodríguez, Eva Codesido, Jacobo Cruces, José M Brea, María I Loza, Francisco Alén, Joaquin Botta, Peter J McCormick, Juan A Ballesteros, Bellinda Benhamú, Fernando Rodriguez de Fonseca, María L López-Rodrí Guez
The 5-HT2CR agonist lorcaserin, clinically approved for the treatment of obesity, causes important side effects mainly related to subtype selectivity. In the search for 5-HT2CR allosteric modulators as safer anti-obesity drugs, a chemical library from Vivia Biotech was screened using ExviTech® platform. Structural modifications of identified hit VA240 in synthesized analogues 6-41 afforded compound 11 (N-[(1-benzyl-1H-indol-3-yl)methyl]pyridin-3-amine, VA012), which exhibited dose-dependent enhancement of serotonin efficacy, no significant off-target activities, and low binding competition with serotonin or other orthosteric ligands...
November 8, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29116116/urinary-sulphatoxymelatonin-as-a-biomarker-of-serotonin-status-in-biogenic-amine-deficient-patients
#15
Marta Batllori, Marta Molero-Luis, Luisa Arrabal, Javier de Las Heras, Joaquín-Alejandro Fernandez-Ramos, Luis González Gutiérrez-Solana, Salvador Ibáñez-Micó, Rosario Domingo, Jaume Campistol, Aida Ormazabal, Frederic Sedel, Thomas Opladen, Basiliki Zouvelou, Roser Pons, Angels Garcia-Cazorla, Eduardo Lopez-Laso, Rafael Artuch
Melatonin is synthesized from serotonin and it is excreted as sulphatoxymelatonin in urine. We aim to evaluate urinary sulphatoxymelatonin as a biomarker of brain serotonin status in a cohort of patients with mutations in genes related to serotonin biosynthesis. We analized urinary sulphatoxymelatonin from 65 healthy subjects and from 28 patients with genetic defects. A total of 18 patients were studied: 14 with autosomal dominant and recessive guanosine triphosphate cyclohydrolase-I deficiency; 3 with sepiapterin reductase deficiency; and 1 with aromatic L-amino acid decarboxylase deficiency...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29113536/the-pigmented-epithelium-a-bright-partner-against-photoreceptor-degeneration
#16
Joaquín Letelier, Paola Bovolenta, Juan R Martínez-Morales
Sight depends on the intimate association between photoreceptors and pigment epithelial cells. The evolutionary origin of this cellular tandem can be traced back to the emergence of bilateral animals, at least 450 million years ago, as they define the minimal unit of the ancestral prototypic eye. Phototransduction is a demanding process from the energetic and homeostatic points of view, and not surprisingly photoreceptive cells are particularly susceptible to damage and degeneration. Here, we will examine the different ancillary roles that the pigmented cells play in the physiology and homeostasis of photoreceptors, linking each one of these processes to the most common hereditary retinal diseases...
November 7, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29112861/long-fiber-carbon-nanotubes-replicate-asbestos-induced-mesothelioma-with-disruption-of-the-tumor-suppressor-gene-cdkn2a-ink4a-arf
#17
Tatyana Chernova, Fiona A Murphy, Sara Galavotti, Xiao-Ming Sun, Ian R Powley, Stefano Grosso, Anja Schinwald, Joaquin Zacarias-Cabeza, Kate M Dudek, David Dinsdale, John Le Quesne, Jonathan Bennett, Apostolos Nakas, Peter Greaves, Craig A Poland, Ken Donaldson, Martin Bushell, Anne E Willis, Marion MacFarlane
Mesothelioma is a fatal tumor of the pleura and is strongly associated with asbestos exposure. The molecular mechanisms underlying the long latency period of mesothelioma and driving carcinogenesis are unknown. Moreover, late diagnosis means that mesothelioma research is commonly focused on end-stage disease. Although disruption of the CDKN2A (INK4A/ARF) locus has been reported in end-stage disease, information is lacking on the status of this key tumor suppressor gene in pleural lesions preceding mesothelioma...
November 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29112324/de-novo-assembly-of-the-zucchini-genome-reveals-a-whole-genome-duplication-associated-with-the-origin-of-the-cucurbita-genus
#18
Javier Montero-Pau, José Blanca, Aureliano Bombarely, Peio Ziarsolo, Cristina Esteras, Carlos Martí-Gómez, María Ferriol, Pedro Gómez, Manuel Jamilena, Lukas Mueller, Belén Picó, Joaquín Cañizares
The Cucurbita genus (squashes, pumpkins and gourds) includes important domesticated species such as C. pepo, C. maxima and C. moschata. In this study, we present a high-quality draft of the zucchini (C. pepo) genome. The assembly has a size of 263 Mb, a scaffold N50 of 1.8 Mb, and 34,240 gene models. It includes 92% of the conserved BUSCO core gene set, and it is estimated to cover 93.0% of the genome. The genome is organized in 20 pseudomolecules that represent 81.4% of the assembly, and it is integrated with a genetic map of 7,718 SNPs...
November 7, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29111467/reverse-shoulder-arthroplasty-in-weight-bearing-shoulders-of-wheelchair-dependent-patients
#19
Eduard Alentorn-Geli, Nathan R Wanderman, Andrew T Assenmacher, Joaquín Sánchez-Sotelo, Robert H Cofield, John W Sperling
BACKGROUND: Wheelchair-dependent patients rely on their upper extremities for mobility and transfers. This entails the heavy use of upper extremities as weight-bearing joints, leading to shoulder overuse with increased prevalence of rotator cuff-related disorders, and ultimately to challenging cases for shoulder surgeons when a joint replacement is needed. OBJECTIVE: To report the outcomes of reverse shoulder arthroplasty (RSA) in wheelchair-dependent patients with arthritis and rotator cuff tears...
October 27, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29108008/insights-into-the-molecular-evolution-of-peptidase-inhibitors-in-arthropods
#20
Joaquin Alonso, Manuel Martinez
Peptidase inhibitors are key proteins involved in the control of peptidases. In arthropods, peptidase inhibitors modulate the activity of peptidases involved in endogenous physiological processes and peptidases of the organisms with which they interact. Exploring available arthropod genomic sequences is a powerful way to obtain the repertoire of peptidase inhibitors in every arthropod species and to understand the evolutionary mechanisms involved in the diversification of this kind of proteins. A genomic comparative analysis of peptidase inhibitors in species belonging to different arthropod taxonomic groups was performed...
2017: PloS One
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