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Xerostomia

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https://www.readbyqxmd.com/read/29034187/electrical-nerve-stimulation-for-xerostomia-a-meta-analysis-of-randomised-controlled-trials
#1
REVIEW
Gowri Sivaramakrishnan, Kannan Sridharan
BACKGROUND: Xerostomia leads to caries, infection and overall psychological discomfort. Salivary substitutes and pharmacological agents have been tried only with temporary relief. The use of transcutaneous electrical nerve stimulation (TENS) has been contemplated on by various researchers for treatment of xerostomia. We carried out the present review as a systematic compilation and quantitative synthesis of the existing evidence related to the utility of TENS in patients with xerostomia...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28994603/suvorexant-scientifically-interesting-utility-uncertain
#2
Nicholas A Keks, Judy Hope, Simone Keogh
OBJECTIVE: Suvorexant, a new hypnotic, is indicated for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance, and is used long-term. This paper will briefly review suvorexant. RESULTS: Orexin is a hypothalamic peptide which promotes wakefulness. By blocking orexin receptors, suvorexant induces sleep. Peaking 2 h after ingestion, it has a half-life of 12 h and is hepatically metabolized mainly by CYP3A. Kinetics are not affected by age but concentrations are higher in females and obese patients...
October 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28986509/why-targeting-psma-is-a-game-changer-in-the-management-of-prostate-cancer-%C3%A2-a-urologist-s-point-of-view
#3
Nicholas M Donin, Robert Reiter
Prostate-specific membrane antigen (PSMA), is a transmembrane glycoprotein that is highly expressed on prostate adenocarcinomas, exhibits only limited expression in benign and extra-prostatic tissues, and thus represents an ideal target for the diagnosis and management of prostate cancer. Since its discovery over 30 years ago, significant effort has been made to develop clinical technology targeting PSMA. The last 5 years have seen an explosion of development of new agents targeting PSMA for diagnostic and therapeutic use...
October 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28985953/effects-of-biodegradable-hydrogel-spacer-injection-on-contralateral-submandibular-gland-sparing-in-radiotherapy-for-head-and-neck-cancers
#4
Avani D Rao, Stephanie Coquia, Robert De Jong, Christine Gourin, Brandi Page, Diane Latronico, Samson Dah, Lin Su, Stephen Clarke, Jeffrey Schultz, Lauren M Rosati, Carole Fakhry, John Wong, Theodore L DeWeese, Harry Quon, Kai Ding, Ana Kiess
Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.
October 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28972794/can-sparing-of-the-superficial-contralateral-parotid-lobe-reduce-xerostomia-following-radiotherapy-for-head-and-neck-cancer
#5
Daan Nevens, Sandra Nuyts
OBJECTIVE: The purpose of this study is to see whether sparing the superficial contralateral parotid lobe can help limiting xerostomia following radiotherapy for head and neck cancer. METHODS: Eighty-eight patients that were included in 2 prospective randomized studies, were analysed in the current study. Using the dosimetry of both the parotid glands, we divided our patients in 4 groups. Group 1 includes patients where we were able to reduce the radiation dose below the threshold in order to spare both the ipsilateral and contralateral parotid glands, group 2 consist of patients where only the contralateral parotid gland could be spared...
October 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28966960/seeking-optimal-management-for-radioactive-iodine-therapy-induced-adverse-effects
#6
REVIEW
Andreas Charalambous
Radioactive iodine therapy (RAIT) is one of the important treatment modalities in the management of differentiated thyroid cancer (DTC). RAIT with iodine-131 has long been used in the management of DTC for the ablation of residual thyroid or treatment of its metastases. Despite being reasonably safe, radioiodine therapy is not always without side effects. Even relatively low administered activities of RAIT used for remnant ablation have been associated with the more clinically significant side effects of sialadenitis, xerostomia, salivary gland pain and swelling, dry eyes, excessive tearing, or alterations in taste in as many as 25% of patients...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28959172/the-outcome-of-the-first-100-nasopharyngeal-cancer-patients-in-thailand-treated-by-helical-tomotherapy
#7
Imjai Chitapanarux, Wannapha Nobnop, Patumrat Sripan, Ausareeya Chumachote, Ekkasit Tharavichitkul, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Bongkot Jia-Mahasap, Suwapim Janlaor, Patcharawadee Kayan, Patrinee Traisathit, Dirk Van Gestel
BACKGROUND: The aim of the study was to analyse of two-year loco-regional failure free survival (LRFFS), distant metastasis free survival (DMFS), overall survival (OS), and toxicity outcomes of the first 100 nasopharyngeal carcinoma patients in Thailand treated by helical tomotherapy. PATIENTS AND METHODS: Between March 2012 and December 2015, 100 patients with non-metastatic nasopharyngeal carcinoma were treated by helical tomotherapy. All patients were treated by platinum-based concurrent chemoradiotherapy and adjuvant or neo-adjuvant chemotherapy...
September 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28951008/patient-specific-bolus-for-range-shifter-air-gap-reduction-in-intensity-modulated-proton-therapy-of-head-and-neck-cancer-studied-with-monte-carlo-based-plan-optimization
#8
Steven Michiels, Ana Maria Barragán, Kevin Souris, Kenneth Poels, Wouter Crijns, John A Lee, Edmond Sterpin, Sandra Nuyts, Karin Haustermans, Tom Depuydt
BACKGROUND & PURPOSE: Intensity-modulated proton therapy (IMPT) of superficial lesions requires pre-absorbing range shifter (RS) to deliver the more shallow spots. RS air gap minimization is important to avoid spot size degradation, but remains challenging in complex geometries such as in head-and-neck cancer (HNC). In this study, clinical endpoints were investigated for patient-specific bolus and for conventional RS solutions, making use of a Monte Carlo (MC) dose engine for IMPT optimization...
September 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28951007/-18-f-fdg-pet-image-biomarkers-improve-prediction-of-late-radiation-induced-xerostomia
#9
Lisanne V van Dijk, Walter Noordzij, Charlotte L Brouwer, Ronald Boellaard, Johannes G M Burgerhof, Johannes A Langendijk, Nanna M Sijtsema, Roel J H M Steenbakkers
BACKGROUND AND PURPOSE: Current prediction of radiation-induced xerostomia 12months after radiotherapy (Xer12m) is based on mean parotid gland dose and baseline xerostomia (Xerbaseline) scores. The hypothesis of this study was that prediction of Xer12m is improved with patient-specific characteristics extracted from (18)F-FDG PET images, quantified in PET image biomarkers (PET-IBMs). PATIENTS AND METHODS: Intensity and textural PET-IBMs of the parotid gland were collected from pre-treatment (18)F-FDG PET images of 161 head and neck cancer patients...
September 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28947989/intensity-modulated-radiotherapy-has-superior-outcomes-to-three-dimensional-conformal-radiotherapy-in-patients-with-stage-ie-iie-extranodal-nasal-type-natural-killer-t-cell-lymphoma
#10
Yi-Yang Li, Hai-Qun Lin, Lu-Lu Zhang, Ling-Ling Feng, Shao-Qing Niu, Han-Yu Wang, Yu-Jing Zhang, Xi-Cheng Wang
We compared the treatment outcomes, toxicities and prognoses of patients with stage IE-IIE extranodal natural killer/T-cell lymphoma (ENKTL) treated with intensity-modulated radiotherapy (IMRT) or three-dimensional conformal radiotherapy (3DCRT). Newly diagnosed early-stage ENKTL patients (N = 173) were enrolled and received extended involved-field radiotherapy following induction chemotherapy. Patients were treated with 3DCRT (n = 98) or IMRT (n = 75). One-to-one matching of the IMRT and 3DCRT groups was performed through propensity score matching, which yielded 23 pairs of patients...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28945293/correlation-among-ocular-surface-disease-xerostomia-and-nasal-symptoms-in-patients-with-differentiated-thyroid-carcinoma-subjected-to-radioiodine-therapy-a-prospective-comparative-study
#11
Fabricio Lopes da Fonseca, Patricia Kazue Yamanaka, Luciana Mazoti, Lica Arakawa-Sugueno, Juliana Mika Kato, Suzana Matayoshi
BACKGROUND: Some complications of radioiodine therapy have been reported, but the involvement of the eyes and adnexa is rarely discussed. The purpose of this study was to determine the correlation among ocular surface changes, xerostomia, and changes in the nasal mucosa associated with radioiodine therapy. METHODS: Patients subjected to radioiodine therapy (group 1) or not subjected (group 2) were prospectively evaluated by examinations of the ocular surface and tear film, saliva production, and nasal endoscopy...
September 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28941224/hard-palate-hyperpigmentation-a-rare-side-effect-of-antimalarials
#12
Karin Manger, Ulrich von Streitberg, Gerhard Seitz, Arnd Kleyer, Bernhard Manger
A 50-year old female Caucasian patient with marked xerostomia, xerophthalmia, relapsing parotid swelling, arthralgias, and fatigue had been treated with chloroquine diphosphate (250 mg/day) for four years, when a painless bluish-grey hyperpigmentation of her hard palate was noticed during one of her rheumatologic follow-up visits (A). To rule out malignancy or infection, a mucosal biopsy was performed and histology showed subepithelial granular pigment depositions among collagen fibres and within macrophages (B)...
September 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28941123/renal-involvement-in-primary-sj%C3%A3-gren-s-syndrome-a-retrospective-study-of-103-biopsy-proven-cases-from-a-single-center-in-china
#13
Hua-Xia Yang, Jing Wang, Yu-Bing Wen, Yun-Yun Fei, Meng-Di Jiang, Meng-Yu Zhou, Wen Zhang, Hang Li, Xue-Mei Li, Feng-Chun Zhang, Xue-Wang Li, Xuan Zhang, Li-Meng Chen
AIM: To retrospectively investigate the features of renal involvements in patients with primary Sjögren's syndrome (pSS) with biopsy results. METHODS: A total of 2096 pSS inpatients at Peking Union Medical College Hospital in China from 2005 to 2015 were identified. Patients with biopsy-proven renal involvement (SS-renal) and matched controls (SS-only) were recruited. The clinical and pathologic features as well as treatments and outcomes were systematically analyzed...
September 21, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28940566/anticholinergic-burden-and-dry-mouth-among-finnish-community-dwelling-older-adults
#14
Antti Tiisanoja, Anna-Maija Syrjälä, Kaija Komulainen, Pasi Lampela, Sirpa Hartikainen, Heidi Taipale, Matti Knuuttila, Pekka Ylöstalo
OBJECTIVE: The aim was to study whether the anticholinergic burden of drugs is related to xerostomia and salivary secretion among community-dwelling elderly people. BACKGROUND: Anticholinergic drugs have been shown to be a risk factor for dry mouth, but little is known about the effects of cumulative exposure to anticholinergic drugs measured by anticholinergic burden on salivary secretion or xerostomia. METHODS: The study population consisted of 152 community-dwelling, dentate, non-smoking, older people from the Oral Health GeMS study...
September 21, 2017: Gerodontology
https://www.readbyqxmd.com/read/28939226/geometric-image-biomarker-changes-of-the-parotid-gland-are-associated-with-late-xerostomia
#15
Lisanne V van Dijk, Charlotte L Brouwer, Hans Paul van der Laan, Johannes G M Burgerhof, Johannes A Langendijk, Roel J H M Steenbakkers, Nanna M Sijtsema
PURPOSE: To identify a surrogate marker for late xerostomia 12 months after radiation therapy (Xer12m), according to information obtained shortly after treatment. METHODS AND MATERIALS: Differences in parotid gland (PG) were quantified in image biomarkers (ΔIBMs) before and 6 weeks after radiation therapy in 107 patients. By performing stepwise forward selection, ΔIBMs that were associated with Xer12m were selected. Subsequently other variables, such as PG dose and acute xerostomia scores, were added to improve the prediction performance...
August 12, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28935947/mucin-5b-in-saliva-and-serum-of-patients-with-oral-lichen-planus
#16
Farzaneh Agha-Hosseini, Mojtaba Imanpour, Iraj Mirzaii-Dizgah, Mahdieh-Sadat Moosavi
Oral lichen planus (OLP) is among the most common oral diseases. Its etiopathogenesis has yet to be clearly identified. OLP patients complain of mouth dryness. This study aimed to assess the level of Mucin 5B in OLP patients with xerostomia. This study was conducted on 30 OLP patients and 30 healthy individuals. In addition to patient complaint of mouth dryness, xerostomia was assessed by tongue blade and lipstick tests. Stimulated and unstimulated saliva were collected in plastic vials by spitting method. Level of Mucin 5B was measured by ELISA...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28932047/a-relationship-between-salivary-flow-rates-and-candida-counts-in-patients-with-xerostomia
#17
Suchetha Devendrappa Nadig, Deepak Timmasandra Ashwathappa, Muniraju Manjunath, Sowmya Krishna, Araleri Gopalkrishna Annaji, Praveen Kunigal Shivaprakash
CONTEXT: Most of the adult population is colonized by Candida in their oral cavity. The process of colonization depends on several factors, including the interaction between Candida and salivary proteins. Therefore, salivary gland hypofunction may alter the oral microbiota and increase the risk for opportunistic infections, such as candidiasis. Hence, it is necessary to evaluate the relationship between salivary flow rates (SFRs) and Candida colony counts in the saliva of patients with xerostomia...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28930222/add-on-complementary-medicine-in-cancer-care-evidence-in-literature-and-experiences-of-integration
#18
REVIEW
Elio Rossi, Mariella Di Stefano, Fabio Firenzuoli, Maria Valeria Monechi, Sonia Baccetti
Background: According to the literature an increasing number of cancer patients demand for complementary therapies during their disease. Research has demonstrated that some of these therapies are effective and safe as adjunctive treatments in specific symptoms of these patients. Methods: The aims of the paper are to review the main and recent papers of international literature on the effectiveness of complementary medicine (CM) therapies on side effects of anti-cancer protocols and improvement in the quality of life of oncological patients, and to describe the integration of evidence-based acupuncture, herbal medicine and homeopathy treatments in Public Cancer Network of the region of Tuscany...
January 24, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28916028/etiology-evaluation-and-management-of-xerostomia
#19
Jillian W Millsop, Elizabeth A Wang, Nasim Fazel
Xerostomia is defined as the complaint of oral dryness. It is a condition that primarily affects older adults and can have a significant negative effect on one's quality of life. Patients with xerostomia often do not have objective signs of hyposalivation. The underlying etiology of xerostomia includes a variety of systemic diseases and local factors. Our aim is to provide a comprehensive review of the differential diagnosis, evaluation, and management of xerostomia. Prompt diagnosis and management can alleviate the clinical manifestations of this debilitating condition...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28911982/upper-aerodigestive-tract-cancer-and-oral-health-status-before-radiotherapy-a-cross-sectional-study-of-154-patients
#20
A Raskin, M Ruquet, L Weiss-Pelletier, J Mancini, O Boulogne, J Michel, N Fakhry, J M Foletti, C Chossegros, R Giorgi
OBJECTIVES: We aimed to determine primarily the oral health status of patients with upper aerodigestive tract cancer before radiotherapy, and secondarily the prevalence of risk factors for poor oral status. METHODS: A cross-sectional study was conducted in Marseille University hospital. Assessment criteria were the Decay, Missing and Filled (DMF) Index and periodontal status. RESULTS: One hundred and fifty-four patients, mean age 60.9years, were included...
September 12, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
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