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Xerostomia

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https://www.readbyqxmd.com/read/28821277/the-feasibility-analysis-of-omission-of-elective-irradiation-to-level-ib-lymph-nodes-in-low-risk-nasopharyngeal-carcinoma-based-on-the-2013-updated-consensus-guideline-for-neck-nodal-levels
#1
Xiaomin Ou, Yibing Miao, Xiaoshen Wang, Jianhui Ding, Xiayun He, Chaosu Hu
BACKGROUND: Level IB metastasis is rare in nasopharyngeal carcinoma (NPC). The purpose of this study is to investigate the high-risk factors for level IB metastasis and evaluate the feasibility of omission of elective irradiation to level IB in the low-risk subgroups in NPC. METHODS: This retrospective study identified 532 patients with NPC treated by definitive radiation in our institution from 2009 to 2010. Level IB nodes were electively irradiated based on the physician's decision...
August 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28814903/ixeris-dentata-extract-regulates-salivary-secretion-through-the-activation-of-aquaporin-5-and-prevents-diabetes-induced-xerostomia
#2
Kashi Raj Bhattarai, Sang-Won Lee, Seung Hyun Kim, Hyung-Ryong Kim, Han-Jung Chae
The aim of this study was to investigate the effects of Ixeris dentata (IXD) extract to improve the salivation rate in dry mouth induced by diabetes. Both control and diabetic rats were treated with a sublingual spray of either water or IXD extract to determine the effects of IXD on salivation. During the study, we observed that IXD extract treatment increased the salivary flow rate in diabetic rats. The expression of α-amylase was increased significantly in both saliva and glandular tissue lysates of IXD-treated diabetic rats...
2017: Journal of Experimental Pharmacology
https://www.readbyqxmd.com/read/28814900/acidic-oral-moisturizers-with-ph-below-6-7-may-be-harmful-to-teeth-depending-on-formulation-a-short-report
#3
Alex J Delgado, Vilhelm G Olafsson
Xerostomia affects 30% of the population and manifests as a side effect of medications, systemic diseases, or cancer therapy. Oral moisturizers are prescribed to overcome the ailments of dry mouth and its symptoms. It is imperative that these products help to restore hyposalivation and that they do not present any secondary effect that can harm oral health. It has been shown in the literature that some oral moisturizers may have an erosive potential due to their acidic pH, which is below the critical pH of dentin and enamel...
2017: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/28809366/oral-manifestations-of-diabetes-mellitus-a-systematic-review
#4
E Mauri-Obradors, A Estrugo-Devesa, E Jané-Salas, M Viñas, J López-López
BACKGROUND: Diabetes Mellitus has become a global epidemic and presents many complications, usually proportional to the degree and duration of hyperglycemia. The aim of this systematic review was to investigate the different oral manifestations associated with Diabetes Mellitus. MATERIAL AND METHODS: A MEDLINE search for "Diabetes Mellitus and oral manifestations" was performed. A further search was conducted for "diabetes" and its individual oral manifestation...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28800899/lycopene-spray-probably-does-not-improve-the-symptoms-of-drug-induced-xerostomia-in-older-adults
#5
Romina Brignardello-Petersen
No abstract text is available yet for this article.
August 5, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28771254/multiplex-epithelium-dysfunction-due-to-cldn10-mutation-the-helix-syndrome
#6
Smail Hadj-Rabia, Gaelle Brideau, Yasser Al-Sarraj, Rachid C Maroun, Marie-Lucile Figueres, Stéphanie Leclerc-Mercier, Eric Olinger, Stéphanie Baron, Catherine Chaussain, Dominique Nochy, Rowaida Z Taha, Bertrand Knebelmann, Vandana Joshi, Patrick A Curmi, Marios Kambouris, Rosa Vargas-Poussou, Christine Bodemer, Olivier Devuyst, Pascal Houillier Md PhD, Hatem El-Shanti
PurposeWe aimed to identify the genetic cause to a clinical syndrome encompassing hypohidrosis, electrolyte imbalance, lacrimal gland dysfunction, ichthyosis, and xerostomia (HELIX syndrome), and to comprehensively delineate the phenotype.MethodsWe performed homozygosity mapping, whole-genome sequencing, gene sequencing, expression studies, functional tests, protein bioinformatics, and histological characterization in two unrelated families with HELIX syndrome.ResultsWe identified biallelic missense mutations (c...
August 3, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28770414/oral-status-quality-of-life-and-anxiety-and-depression-in-hemodialysis-patients-and-the-effect-of-the-duration-of-treatment-by-dialysis-on-these-variables
#7
F Camacho-Alonso, C Cánovas-García, C Martínez-Ortiz, T De la Mano-Espinosa, T Ortuño-Celdrán, J I Marcello-Godino, R Ramos-Sánchez, M Sánchez-Siles
This study aimed is to evaluate the oral health status, quality of life, anxiety and depression among hemodialysis patients and to analyze the effect of the duration of dialysis on these variables. 120 patients on hemodialysis and 120 control subjects underwent oral examination, periodontal evaluation, xerostomia study using a Visual Analogue Scale (VAS), sialometry evaluation; quality of life (QOL) using the OHIP-14 questionnaire and anxiety/depression. Bleeding index, CPTIN, clinical attachment level, and probing depth were significantly higher in the hemodialysis group than the control group (p < 0...
August 2, 2017: Odontology
https://www.readbyqxmd.com/read/28767676/salivary-flow-and-xerostomia-in-older-patients-with-type-2-diabetes-mellitus
#8
Danilo Lopes Ferreira Lima, Sandro Dias Rocha Mendes Carneiro, Fladia Taciana de Sousa Barbosa, Maria Vieira de Lima Saintrain, Jean André Hervé Moizan, Jean Doucet
OBJECTIVES: To assess salivary flow in older patients with type 2 diabetes mellitus (DM2) and its association with xerostomia. METHODS: Cross-sectional clinical study conducted with older patients diagnosed with type 2 diabetes for at least one year receiving treatment at the Integrated Center for Diabetes and Hypertension of Ceará (CIHD) in the city of Fortaleza, Ceará, Northeastern Brazil. Oral clinical examination was carried out to assess the decayed, missing and filled teeth index (DMFT)...
2017: PloS One
https://www.readbyqxmd.com/read/28766746/sensory-effects-of-transient-receptor-potential-channel-agonists-on-whole-mouth-saliva-extensional-rheology
#9
Jack William Houghton, Joachim Hans, Manuel Pesaro, Jakob Peter Ley, Guy Howard Carpenter, Gordon Proctor
The extensional rheology (ER) of saliva is a property associated with its ability to coat surfaces and is important for the maintenance of a normal mouth feeling. Transient receptor potential (TRP) channels are expressed in the oral cavity and this study investigated how the sensory effects of TRP channel agonists modify the ER of saliva. Healthy volunteers rinsed with solutions containing a TRP agonist. Unstimulated whole mouth saliva (WMS) was collected prior to rinsing and WMS was collected during the first and second minutes after the mouth rinse...
August 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28764287/aloe-vera-for-dry-mouth-denture-patients-palliative-therapy
#10
Abdul Habeeb Bin Mohsin, S Varalakshmi Reddy, M Praveen Kumar, Sarah Samee
INTRODUCTION: Xerostomia (dry mouth) is dryness of the mouth which is due to reduced salivary flow. Lack of adequate saliva causes discomfort in denture wearing patients and decreases retention of dentures. The ability of saliva to wet the tissue surface is one of the most important properties for oral comfort and retention of complete denture in dry mouth patients. AIM: This study was conducted to evaluate and compare the wetting ability of therapeutic Aloe vera saliva substitute and commercially available Aqwet saliva substitute on heat-polymerized acrylic resin...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28759866/oral-health-impacts-of-medications-used-to-treat-mental-illness
#11
N Cockburn, A Pradhan, M W Taing, S Kisely, P J Ford
BACKGROUND: Many psychotropic medications affect oral health. This review identified oral side effects for antidepressant, antipsychotic, anticonvulsant, antianxiety and sedative drugs that are recommended in Australia for the management of common mental illnesses and provides recommendations to manage these side-effects. METHODS: The Australian Therapeutic Guidelines and the Australian Medicines Handbook were searched for medications used to treat common mental health conditions...
July 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28759822/treatment-of-late-sequelae-after-radiotherapy-for-head-and-neck-cancer
#12
REVIEW
Primož Strojan, Katherine A Hutcheson, Avraham Eisbruch, Jonathan J Beitler, Johannes A Langendijk, Anne W M Lee, June Corry, William M Mendenhall, Robert Smee, Alessandra Rinaldo, Alfio Ferlito
Radiotherapy (RT) is used to treat approximately 80% of patients with cancer of the head and neck. Despite enormous advances in RT planning and delivery, a significant number of patients will experience radiation-associated toxicities, especially those treated with concurrent systemic agents. Many effective management options are available for acute RT-associated toxicities, but treatment options are much more limited and of variable benefit among patients who develop late sequelae after RT. The adverse impact of developing late tissue damage in irradiated patients may range from bothersome symptoms that negatively affect their quality of life to severe life-threatening complications...
July 18, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28759701/pharmacological-interventions-for-preventing-dry-mouth-and-salivary-gland-dysfunction-following-radiotherapy
#13
REVIEW
Philip Riley, Anne-Marie Glenny, Fang Hua, Helen V Worthington
BACKGROUND: Salivary gland dysfunction is an 'umbrella' term for the presence of either xerostomia (subjective sensation of dryness), or salivary gland hypofunction (reduction in saliva production). It is a predictable side effect of radiotherapy to the head and neck region, and is associated with a significant impairment of quality of life. A wide range of pharmacological interventions, with varying mechanisms of action, have been used for the prevention of radiation-induced salivary gland dysfunction...
July 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28756881/self-reported-oral-health-and-xerostomia-in-adult-patients-with-celiac-disease-versus-a-comparison-group
#14
Tom van Gils, Gerd Bouma, Hetty J Bontkes, Chris J J Mulder, Henk S Brand
OBJECTIVES: This study aimed to assess the impact of celiac disease (CD) on oral health and xerostomia. STUDY DESIGN: Members of the Dutch Celiac Society (n = 5522) were invited to complete an online questionnaire based on the Oral Health Impact Profile 14 (OHIP-14) and Xerostomia Inventory (XI). Acquaintances and partners of the CD respondents served as the comparison group. In total, data of 740 patients with CD and 270 comparison participants were evaluated...
August 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28749607/assessment-of-relationship-between-xerostomia-and-oral-health-related-quality-of-life-in-patients-with-rheumatoid-arthritis
#15
Goli Chamani, Mohammad Reza Shakibi, Mohammad Reza Zarei, Maryam Rad, Adeleh Pouyafard, Ardavan Parhizkar, Mojdeh Mansoori
OBJECTIVE: To determine the relationship between xerostomia and Oral-Health Related Quality of Life in patients with rheumatoid arthritis. MATERIALS AND METHODS: Two hundred patients with rheumatoid arthritis were assessed using Fox and OHIP-14 questionnaires concerning xerostomia and Oral-Health Related Quality of Life respectively. The sum of decayed, missing and filled teeth (DMFT) was determined via an intra-oral exam. In addition, intergroup comparisons were evaluated using T-test, Chi-square, regression and Tukey analysis...
July 27, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28741683/a-clinical-trial-of-a-novel-emulsion-for-potential-use-as-a-saliva-substitute-in-patients-with-radiation-induced-xerostomia
#16
Olivia Apperley, Natalie Medlicott, Alison Rich, Sara Hanning, Maggie-Lee Huckabee
AIM: Researchers have recently developed a novel oily formulation for potential use as a saliva substitute for the treatment of dry mouth. The aim of this randomised, cross-over study was to compare this new formulation to a currently available saliva substitute and a control of water on measures of mastication, subjective feeling of oral dryness and product acceptability. METHODS: Forty participants treated with radiotherapy to the head and neck and experiencing xerostomia were invited to participate in the trial...
July 25, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28733180/association-between-malnutrition-and-oral-health-in-dutch-nursing-home-residents-results-of-the-lpz-study
#17
Viviënne A L Huppertz, Gert-Jan van der Putten, Ruud J G Halfens, Jos M G A Schols, Lisette C P G M de Groot
INTRODUCTION: According to the World Health Organization (WHO) and FDI World Dental Federation (FDI), malnutrition and bad oral health are of great concern to global health, especially among the older population. This study aimed to assess the associations between oral health problems ([artificial] teeth problems, chewing problems, and xerostomia) and malnutrition in residents of somatic and psychogeriatric wards in Dutch nursing homes. METHODS: Data of the cross-sectional National Prevalence Measurement of Quality of Care study (Landelijke Prevalentiemeting Zorgproblemen study) in the Netherlands were used to evaluate nutritional status and oral health of 3220 residents, aged 65 or older and living in somatic or psychogeriatric wards in Dutch nursing homes...
July 18, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28726805/prepl-deficiency-delineation-of-the-phenotype-and-development-of-a-functional-blood-assay
#18
Luc Régal, Emma Mårtensson, Isabelle Maystadt, Nicol Voermans, Damien Lederer, Alberto Burlina, María Jesús Juan Fita, A Jeannette M Hoogeboom, Mia Olsson Engman, Tess Hollemans, Meyke Schouten, Sandra Meulemans, Tord Jonson, Inge François, David Gil Ortega, Erik-Jan Kamsteeg, John W M Creemers
PurposePREPL deficiency causes neonatal hypotonia, ptosis, neonatal feeding difficulties, childhood obesity, xerostomia, and growth hormone deficiency. Different recessive contiguous gene deletion syndromes involving PREPL and a variable combination of SLC3A1 (hypotonia-cystinuria syndrome), CAMKMT (atypical hypotonia-cystinuria syndrome), and PPM1B (2p21 deletion syndrome) have been described. In isolated PREPL deficiency, previously described only once, the absence of cystinuria complicates the diagnosis...
July 20, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28725298/thirst-sensation-and-oral-dryness-following-alcohol-intake
#19
REVIEW
Kiyotoshi Inenaga, Kentaro Ono, Suzuro Hitomi, Ayu Kuroki, Izumi Ujihara
Substantial acute and chronic intakes of alcohol or ethanol (EtOH) severely influence oral sensations, such as thirst and oral dryness (dry mouth, xerostomia). Thirst sensation and oral dryness are primarily caused by the activation of neurons in brain regions, including the circumventricular organs and hypothalamus, which are referred to as the dipsogenic center, and by a decrease in salivary secretion, respectively. The sensation of thirst experienced after heavy-alcohol drinking is widely regarded as a consequence of EtOH-induced diuresis; however, EtOH in high doses induces anti-diuresis...
August 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28721989/oral-changes-in-patients-undergoing-chemotherapy-for-breast-cancer
#20
Shruthi Acharya, Keerthilatha Murlidhar Pai, Sujatha Bhat, Ballal Mamatha, Vadhiraj M Bejadi, Shashidhar Acharya
BACKGROUND: Breast cancer is one of the most common cancers in India. Most of the patients with breast cancer are treated with chemotherapy which has multiple oral complications. AIMS: The objectives of this study were to describe the occurrence of taste disturbances, xerostomia, oral mucositis, oral pigmentation, and candidal and salivary changes among patients receiving chemotherapy for breast cancer. METHODS: Fifty-two women with newly diagnosed breast cancer (without distant metastasis), eligible for adjuvant/neoadjuvant chemotherapy (cyclophosphamide and adriamycin, 4 cycles × 3 weeks), were included in this study...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
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