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Xerostomia

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https://www.readbyqxmd.com/read/28079429/association-between-late-effects-assessed-by-physicians-and-quality-of-life-reported-by-head-and-neck-cancer-survivors
#1
Rikke Daugaard, Trille Kjaer, Christoffer Johansen, Jane Christiansen, Elo Andersen, Anni L Nielsen, Susanne O Dalton
BACKGROUND: Many survivors of head-and-neck cancer (HNC) suffer from late effects. Their overall quality of life deteriorates during treatment, followed by a slow recovery up to five years after treatment. We examined the association between the severity of physician-assessed late effects and the health-related quality of life (HRQoL) reported by survivors of HNC. MATERIAL AND METHODS: The analysis was based on data collected during follow-up for 136 survivors of cancer in the oral cavity, pharynx, larynx, or salivary glands...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28072927/artificial-induction-of-native-aquaporin-1-expression-in-human-salivary-cells
#2
Z Wang, S Pradhan-Bhatt, M C Farach-Carson, M J Passineau
Gene therapy for dry mouth disorders has transitioned in recent years from theoretical to clinical proof of principle with the publication of a first-in-man phase I/II dose escalation clinical trial in patients with radiation-induced xerostomia. This trial used a prototype adenoviral vector to express aquaporin-1 (AQP1), presumably in the ductal cell layer and/or in surviving acinar cells, to drive transcellular flux of interstitial fluid into the labyrinth of the salivary duct. As the development of this promising gene therapy continues, safety considerations are a high priority, particularly those that remove nonhuman agents (i...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28070838/late-toxicity-evolving-radiotherapy-techniques-and-quality-of-life-in-nasopharyngeal-carcinoma
#3
Luciana Lastrucci, Silvia Bertocci, Vittorio Bini, Simona Borghesi, Roberta De Majo, Andrea Rampini, Paola Pernici, Pietro Giovanni Gennari
PURPOSE: To analyze quality of life (QoL) and functional state (FS) by patient-reported outcome (PRO) questionnaires (FACT-G, FACT-NP, PSS-HN, XeQOLS, and EQ-5D-3L) in long-term survivors nasopharyngeal carcinoma (NPC) treated with conventional radiotherapy (RT) and intensity modulated radiotherapy (IMRT). METHODS: 25 patients answered to five questionnaires about QoL and FS. All patients were assessed also for late toxicity. RESULTS: Functional Assessment of Cancer Therapy-General (FACT-G) and Performance Status Scale Head and Neck (PSS-HN) scores were significantly elevated (better QoL) in age <50 years (p = 0...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28053937/prevalence-of-xerostomia-in-patients-referred-to-shiraz-dental-school-shiraz-iran-during-2006-2013
#4
Jannan Ghapanchi, Fahimeh Rezazadeh, Erfan Fakhraee, Aisa Zamani
No abstract text is available yet for this article.
December 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28046804/su-f-j-218-predicting-radiation-induced-xerostomia-by-dosimetrically-accounting-for-daily-setup-uncertainty-during-head-and-neck-imrt
#5
S Park, H Quon, T McNutt, W Plishker, R Shekhar, J Lee
PURPOSE: To determine if the accumulated parotid dosimetry using planning CT to daily CBCT deformation and dose re-calculation can predict for radiation-induced xerostomia. METHODS: To track and dosimetrically account for the effects of anatomical changes on the parotid glands, we propagated physicians' contours from planning CT to daily CBCT using a deformable registration with iterative CBCT intensity correction. A surface mesh for each OAR was created with the deformation applied to the mesh to obtain the deformed parotid volumes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046569/we-ab-207b-08-exploring-and-refining-the-quantec-guideline-to-reduce-severe-hyposalivation-following-imrt-for-head-and-neck-cancer
#6
M Thor, A Owosho, H Rosenburg, S Yom, J Oh, N Riaz, J Tsai, N Lee, J Huryn, C Estilo, J Deasy
PURPOSE: The aim of this study was to investigate the usefulness of the QUANTEC guideline to prevent xerostomia after intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) with respect to follow-up time. In addition, we explored alternative guidelines to further reduce xerostomia. METHODS: The QUANTEC guideline suggests a mean dose to the contralateral (Dmeancontra) parotid<20 Gy, or Dmeancontra and Dmean to the ipsilateral parotid (Dmeanipsi)<25 Gy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039063/encapsulation-of-primary-salivary-gland-cells-in-enzymatically-degradable-poly-ethylene-glycol-hydrogels-promotes-acinar-cell-characteristics
#7
Andrew D Shubin, Timothy J Felong, Brittany E Schutrum, Debria S L Joe, Catherine E Ovitt, Danielle S W Benoit
: Radiation therapy for head and neck cancers leads to permanent xerostomia due to the loss of secretory acinar cells in the salivary glands. Regenerative treatments utilizing primary submandibular gland (SMG) cells show modest improvements in salivary secretory function, but there is limited evidence of salivary gland regeneration. We have recently shown that poly(ethylene glycol) (PEG) hydrogels can support the survival and proliferation of SMG cells as multicellular spheres in vitro...
December 27, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28024718/patterns-of-dysphagia-and-acute-toxicities-in-patients-with-head-and-neck-cancer-undergoing-helical-imrt%C3%A2-concurrent-chemotherapy
#8
Laura B Moroney, Jennifer Helios, Elizabeth C Ward, Jane Crombie, Leesa F Wockner, Clare L Burns, Ann-Louise Spurgin, Claire Blake, Lizbeth Kenny, Brett G M Hughes
BACKGROUND: There is limited prospective data reporting the extent of treatment related toxicities associated with helical Intensity Modulated Radiotherapy (H-IMRT) for head and neck cancer (HNC). The study aim was to investigate severity, peak incidence and recovery patterns of dysphagia and related toxicities in patients undergoing H-IMRT±chemotherapy to examine when patients are experiencing symptoms requiring supportive clinical care. METHODS: Prospective study of 212 patients undergoing H-IMRT...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28006860/paraneoplastic-cerebellar-degeneration-and-lambert-eaton-myasthenia-in-a-patient-with-merkel-cell-carcinoma-and-voltage-gated-calcium-channel-antibodies
#9
Lucia Pavolucci, Giulia Giannini, Maria Pia Giannoccaro, Maria Pia Foschini, Bethan Lang, Patrizia Avoni, Paolo Tinuper, Angela Vincent, Rocco Liguori
INTRODUCTION: Merkel cell carcinoma is a rare cutaneous, aggressive tumor. Although it shares many neuroendocrine features with small cell lung carcinoma, it has only occasionally been reported with paraneoplastic neurological syndromes. METHODS: A healthy 67 year-old man developed acute ataxia, vertigo, and nausea. Subsequently he also developed dysarthria, diplopia, xerostomia, fatigability and progressive anorexia. He underwent a full diagnostic workup and was found to have a high titer of voltage-gated calcium channel antibodies in serum and cerebrospinal fluid, neurophysiological findings compatible with Lambert-Eaton myasthenia and neurological signs compatible with cerebellar degeneration...
December 22, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/28004397/general-health-influences-episodes-of-xerostomia-a-prospective-population-based-study
#10
Luciana da Silva, Emil Kupek, Karen G Peres
OBJECTIVES: The aim of this study was to investigate the associated factors of changes in symptoms of xerostomia (SOX) in adults aged 20-59. METHODS: A prospective population-based study was conducted in 2009 (n = 1720) and 2012 (n = 1222) in the urban area of Florianópolis, SC, Brazil. Information on SOX was collected in both years together with age, family income, years of schooling, smoking habit, alcohol consumption, changes in the body mass index (BMI; kg/m²), medicine use, self-reported diagnosis of chronic diseases, change in hypertension status and in the use and need for dentures, and number of remaining teeth...
December 22, 2016: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/27990487/tuning-hydrogel-properties-to-promote-the-assembly-of-salivary-gland-spheroids-in-3d
#11
Tugba Ozdemir, Eric W Fowler, Shuang Liu, Daniel A Harrington, Robert L Witt, Mary C Farach-Carson, Swati Pradhan-Bhatt, Xinqiao Jia
Current treatments for chronic xerostomia, or "dry mouth", do not offer long-term therapeutic benefits for head and neck cancer survivors previously treated with curative radiation. Towards the goal of creating tissue-engineered constructs for the restoration of salivary gland functions, we developed new hyaluronic acid (HA)-based hydrogels using thiolated HA (HA-SH) and acrylated HA (HA-AES) with a significant molecular weight mismatch. Four hydrogel formulations with varying HA concentration, (1-2.4 wt%) and thiol/acrylate ratios (2/1 to 36/1) and elastic moduli (G': 35 to 1897 Pa, 2 h post-mixing) were investigated...
December 12, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27980737/functional-salivary-reservoir-in-maxillary-complete-denture-technique-redefined
#12
Angel Mary Joseph, Suja Joseph, Nicholas Mathew, Ashwin Thomas Koshy
Complete dentures are poorly tolerated in patients with xerostomia. A salivary reservoir can be incorporated into a denture that provides slow, sustained, and continuous release of salivary substitute. This article describes a simple, cost-effective, and innovative technique of fabrication and designing of functional maxillary salivary reservoir complete denture.
December 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27976483/hyposalivation-and-xerostomia-among-parkinson-s-disease-patients-and-its-impact-on-quality-of-life
#13
Anna Greta Barbe, Anja Heinzler, Sonja Henny Maria Derman, Martin Hellmich, Lars Timmermann, Michael Johannes Noack
OBJECTIVE: Parkinson's disease (PD) adversely affects oral health (OH). However, the informative value of xerostomia compared to objective parameters and its impact on quality of life (QoL) is still unclear. This study aimed to explore whether xerostomia correlates with hyposalivation and to define its impact on OH-related QoL. MATERIALS AND METHODS: Whole stimulated saliva (WSS) was collected from 30 PD patients and 30 matched healthy controls. Objective parameters (Community Periodontal Index of Treatment Needs, plaque/ gingivitis index, mucosa situation and cheilitis angularis), and questionnaires (German Oral Health Impact Profile [OHIPG]-14, visual analogue scale [VAS], xerostomia [yes/no], and the Unified Parkinson's Disease Rating Scale-II) were assessed...
December 14, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27957617/neuromyotonia-as-an-unusual-neurological-complication-of-primary-sj%C3%A3-gren-s-syndrome-case-report-and-literature-review
#14
REVIEW
Fei Xiao
Primary Sjögren's syndrome (PSS) is a systemic autoimmune disorder characterized by chronic inflammation of exocrine glands such as the lachrymal and salivary glands, leading to xerophthalmia and xerostomia. Neurological manifestations are sometimes found in patients with PSS. A variety of neurological complications has been reported in patients with PSS, and both the central nervous system (CNS) and peripheral nervous system (PNS) can be involved in PSS. Several forms of neuropathy, including polyneuropathy, cranial neuropathy, and multiple mononeuropathy, are often seen in PSS patients...
December 12, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27957276/quality-of-life-and-oral-health-in-elderly
#15
Víctor-Manuel Paredes-Rodríguez, Gema Torrijos-Gómez, José González-Serrano, Rosa-María López-Pintor-Muñoz, Miguel-Ángel López-Bermejo, Gonzalo Hernández-Vallejo
BACKGROUND: We want to assess quality of life in elderly patients in relation to the number of remaining teeth, the number of ingested drugs and xerostomía and to determine the correlation between an increased intake of drugs and a greater feeling of dry mouth and to know the most commonly used measures to control xerostomia. MATERIAL AND METHODS: 30 subjects aged between 65 and 95 years (14 males, 16 females) completed the OHIP questionnaire to determine quality of life...
December 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27955902/-prospective-evaluation-of-mouth-and-eye-dryness-induced-by-antimuscarinic-drugs-used-for-neurogenic-overactive-bladder-in-35%C3%A2-patients-with-multiple-sclerosis
#16
L Weglinski, P Manceau, M Thomas-Pohl, F Le Breton, G Amarenco
INTRODUCTION: Mouth and eye dryness are frequently reported by patients with multiple sclerosis (MS) as side effects of antimuscarinic drugs used for neurogenic overactive bladder. We evaluated the impact of antimuscarinic drugs prescription on these symptoms. METHODS: MS patients consulting for overactive bladder were included. Xerostomia were evaluated at baseline and thirty days after treatment by self-reporting questionnaires (Xerostomia Quality of Life [X-Qol] and Xerostomia Questionnaire [XQ]), by salivary flow rate and sugar test...
December 7, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27943254/minimally-invasive-surgery-versus-radiotherapy-chemoradiotherapy-for-small-volume-primary-oropharyngeal-carcinoma
#17
REVIEW
James Howard, Liam Masterson, Raghav C Dwivedi, Faruque Riffat, Richard Benson, Sarah Jefferies, Piyush Jani, James R Tysome, Chris Nutting
BACKGROUND: More than 400,000 cases of oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed each year worldwide and the incidence is rising, partly as a result of human papillomavirus. Human papillomavirus-associated OPSCC affects younger patients and often presents at a higher stage; however, it is associated with a better prognosis.Until recently, first-line management of OPSCC involved chemoradiotherapy, as research had demonstrated comparable survival outcomes when compared with open surgery, with significantly decreased morbidity...
December 11, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27925697/prevalence-of-sj%C3%A3-gren-s-syndrome-in-brazilian-patients-infected-with-human-t-cell-lymphotropic-virus
#18
Daniela Assis do Vale, Jorge Casseb, Augusto César Penalva de Oliveira, Ivo Bussoloti Filho, Suzana Cantanhede Orsini Machado de Sousa, Karem López Ortega
BACKGROUND: Human T-lymphotropic virus type I (HTLV-I) is known to be associated with neoplastic and neurodegenerative changes, and it is believed to be associated with various systemic inflammatory diseases, including Sjögren's syndrome (SS). Although HTLV-I infection is endemic in Brazil, there is no information regarding the association between HTLV-I infection and SS in the Brazilian population. The objective of this study was to determine the prevalence of SS in HTLV-I-infected individuals and the prevalence of HTLV-I infection in individuals diagnosed with SS...
December 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27920611/products-based-on-olive-oil-betaine-and-xylitol-in-the-post-radiotherapy-xerostomia
#19
Margarita Martín, Alicia Marín, Mario López, Olga Liñán, Felipe Alvarenga, David Büchser, Laura Cerezo
AIM: The objective of this study was determining if the use of products based in olive oil, betaine and xylitol are efficacious to decrease the impact of the dry mouth in the quality of life of the patients with xerostomia due to radiotherapy treatment. BACKGROUND: Following therapeutic irradiation of the head and neck, patients with profound xerostomia have complaints associated with oral dryness, speech, and taste. There is no strong evidence that any topical therapy is effective for relieving the symptom of dry mouth...
January 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27918737/influence-of-bethanechol-on-salivary-parameters-in-irradiated-patients
#20
C Cotomacio, L Campos, A Simões, G Jaguar, E-M Crosato, F Abreu-Alves
BACKGROUND: Some studies have shown evidence that the prophylactic use of bethanechol chloride (BC) may be useful in preventing the incidence and/or severity of xerostomia (XT). However, the indication of BC in irradiated patients with XT needs to be better characterized. The study aimed to evaluate the influence of BC on XT, salivary flow rate, and salivary composition in patients previously submitted to head and neck radiotherapy. MATERIAL AND METHODS: Forty five irradiated patients complaining of XT used 50 mg/day of BC for 3 months, and the salivary parameters were evaluated in 4 Phases (Before BC therapy, after one month of BC, 2 months of BC, and 3 months of BC)...
January 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
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