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Xerostomia

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https://www.readbyqxmd.com/read/29470703/guide-for-health-professionals-addressing-oral-care-for-individuals-in-oncological-treatment-based-on-scientific-evidence
#1
Caroline Gomes Carvalho, João Batista Medeiros-Filho, Meire Coelho Ferreira
OBJECTIVE: Oncological treatment can cause changes in the oral cavity compromising oral functions. The aim of the study was, based on a systematic review, to draft a guide directed at the team of health professionals involved in the oral care of oncological patients. METHODS: A systematic search of the literature was performed for articles published between 2000 and April 2017. Searches were made of electronic databases and hand search. The inclusion criteria were systematic reviews of randomized clinical trials (RCTs) and RCTs published in English, involving pediatric and adult oncological patients and focused on the prevention and treatment of oral complications as well as studies addressing the maintenance of oral health...
February 22, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29464006/delivery-of-sonic-hedgehog-gene-repressed-irradiation-induced-cellular-senescence-in-salivary-glands-by-promoting-dna-repair-and-reducing-oxidative-stress
#2
Bo Hai, Qingguo Zhao, Michael A Deveau, Fei Liu
Rationale: Irreversible hypofunction of salivary glands or xerostomia is common in head and neck cancer survivors treated with radiotherapy even when various new techniques are applied to minimize the irradiation (IR) damage. This condition severely impairs the quality of life of patients and can only be temporarily relieved with current treatments. We found recently that transient expression of Sonic Hedgehog (Shh) in salivary glands after IR rescued salivary function, but the underlying mechanisms are not totally clear...
2018: Theranostics
https://www.readbyqxmd.com/read/29452770/single-arm-phase-2-trial-of-elective-nodal-dose-reduction-for-patients-with-locoregionally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#3
Patrick D Maguire, Charles R Neal, Stuart M Hardy, Andrew M Schreiber
PURPOSE: To evaluate a novel chemoradiation therapy (CRT) regimen for patients with squamous cell carcinoma of the head and neck (SCCHN) incorporating a lower intensity modulated radiation therapy dose to electively treated neck lymph nodes than is currently standard. METHODS AND MATERIALS: Eligible patients had locally advanced SCCHN of the oral cavity, oropharynx, larynx, or hypopharynx. The 7-week CRT course consisted of weekly cisplatin at 35 mg/m 2 concurrently with sequential-boost intensity modulated radiation therapy: 36 Gy to high- and low-risk planning target volumes followed by a sequential boost to the high-risk planning target volume to 70 Gy...
December 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29452650/short-term-use-of-alcohol-containing-mouthrinse-does-not-worsen-xerostomia-compared-with-alcohol-free-mouthrinse
#4
Romina Brignardello-Petersen
No abstract text is available yet for this article.
February 9, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29441293/mucocutaneous-manifestations-in-patients-with-chronic-kidney-disease-a-cross-sectional-study
#5
Rattan S Rashpa, Vikram K Mahajan, Pankaj Kumar, Karaninder S Mehta, Pushpinder S Chauhan, Ritu Rawat, Vikas Sharma
Background: Chronic kidney disease (CKD)-associated mucocutaneous manifestations significantly impair the quality of life but often remain understudied. They may also vary across regions, socioeconomic and nutritional status, and racial differences. Objectives: To study the patterns of mucocutaneous disorders and their prevalence in CKD patients irrespective of clinical stage or dialysis status. Materials and Methods: 122 (M:F = 77:45) patients aged 21‒85 (Mean ± SD = 57...
January 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29439690/a-systematic-review-of-the-effects-of-acupuncture-on-xerostomia-and-hyposalivation
#6
Zainab Assy, Henk S Brand
BACKGROUND: Saliva is fundamental to our oral health and our well-being. Many factors can impair saliva secretion, such as adverse effects of prescribed medication, auto-immune diseases (for example Sjögren's syndrome) and radiotherapy for head and neck cancers. Several studies have suggested a positive effect of acupuncture on oral dryness. METHODS: Pubmed and Web of Science were electronically searched. Reference lists of the included studies and relevant reviews were manually searched...
February 13, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29435843/nutrition-management-for-the-head-and-neck-cancer-patient
#7
Denise Ackerman, Meghan Laszlo, Arlene Provisor, Adern Yu
Head and neck cancer (HNC) patients often face multiple nutritional challenges before, during, and after treatment due to the close proximity of the cancer to organs that are vital for normal eating function. Common treatment-related side effects, such as dysphagia, odynophagia, dysgeusia, xerostomia, thick saliva, mucositis, nausea, and vomiting, all further impair the patient's ability to maintain adequate oral intake. Malnutrition and unintentional weight loss in HNC patients during and after treatment are associated with poorer treatment outcomes, increased morbidity and mortality, and poor quality of life, even in overweight and obese patients whose Body Mass Index (BMI) is not suggestive of malnutrition...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29432741/dietary-nitrate-protects-submandibular-gland-from-hyposalivation-in-ovariectomized-rats-via-suppressing-cell-apoptosis
#8
Yipu Xu, Baoxing Pang, Liang Hu, Xiaoyu Feng, Lei Hu, Jingsong Wang, Chunmei Zhang, Songlin Wang
Xerostomia, a major oral symptom of menopause, is a subjective feeling of dry mouth associated with oral pain and difficulties in deglutition and speech, which significantly reduces patient's quality of life. Dietary nitrate, which can be converted to nitric oxide, has multiple physiological functions in the body, including antioxidant activity and vasodilatation; however, its protective effect against xerostomia remains poorly understood. The present study aimed to evaluate the effects of dietary nitrate on estrogen deficiency-induced xerostomia...
February 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29432648/pilocarpine-and-artificial-saliva-for-the-treatment-of-xerostomia-and-xerophthalmia-of-sj%C3%A3-gren-s-syndrome-a-double-blind-control-trial
#9
M Cifuentes, P Del Barrio-Díaz, C Vera-Kellet
BACKGROUND: Sjögren's Syndrome (SS) is associated with xerostomia and xerophthalmia. Pilocarpine stimulates the secretion of saliva. OBJECTIVES: Investigate and compare the efficacy of pilocarpine and artificial saliva as symptomatic treatments for xerostomia and xerophthalmia in patients with SS. PATIENTS AND METHODS: A double-blind, randomized, controlled study was performed. 72 patients with SS were assigned randomly to receive ten drops of pilocarpine (5 mg) or 10 drops of artificial saliva, orally, t...
February 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29428807/the-imprint-of-salivary-secretion-in-autoimmune-disorders-and-related-pathological-conditions
#10
REVIEW
Kashi Raj Bhattarai, Raghupatil Junjappa, Mallikarjun Handigund, Hyung-Ryong Kim, Han-Jung Chae
Xerostomia is a state of oral dryness associated with salivary gland dysfunction and is induced by stress, radiation and chemical therapy, various systemic and autoimmune diseases, and specific medications. Fluid secretion is interrupted by the stimulation of neurotransmitter-induced increase in cytosolic calcium ([Ca 2+ ] i ) in salivary gland acinar cells, prompting the mobilization of ion channels and their transporters. Salivary fluid and protein secretion are principally dependent on parasympathetic and sympathetic nerves...
February 8, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29425763/buccal-drug-delivery-technologies-for-patient-centred-treatment-of-radiation-induced-xerostomia-dry-mouth
#11
REVIEW
Osamah S Malallah, Cristina M Aller Garcia, Gordon B Proctor, Ben Forbes, Paul G Royall
Radiotherapy is a life-saving treatment for head and neck cancers, but almost 100% of patients develop dry mouth (xerostomia) because of radiation-induced damage to their salivary glands. Patients with xerostomia suffer symptoms that severely affect their health as well as physical, social and emotional aspects of their life. The current management of xerostomia is the application of saliva substitutes or systemic delivery of saliva-stimulating cholinergic agents, including pilocarpine, cevimeline or bethanechol tablets...
February 6, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29417292/treatment-toxicities-and-their-impact-on-oral-intake-following-non-surgical-management-for-head-and-neck-cancer-a-3-year-longitudinal-study
#12
Molly K Barnhart, Rachelle A Robinson, Virginia A Simms, Elizabeth C Ward, Bena Cartmill, Sophie J Chandler, Robert I Smee
PURPOSE: Patients who receive (chemo)radiotherapy [(C)RT] for head and neck cancer (HNC) experience multiple treatment effects. However, the presence and recovery of treatment toxicities and how these impact on oral intake over time post-treatment are not fully understood. The primary aim of this study was to examine patient perceptions of the toxicities present and which are barriers to oral intake, up to 3 years post (C)RT. The secondary aim was to identify mealtime strategies used to optimise oral intake...
February 7, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29409366/oral-shedding-of-hsv-1-and-ebv-and-oral-manifestations-in-paediatric-chronic-kidney-disease-patients-and-renal-transplant-recipients
#13
Rubens Caliento, Dmitry José de Santana Sarmento, Érika Mont'alverne Pereira Silva, Tânia Regina Tozetto-Mendoza, Priscila Lie Tobouti, Vanda Benini, Paulo Henrique Braz-Silva, Marina Gallottini
OBJECTIVE: Previous research demonstrated that salivary shedding of HSV-1 and EBV occurs often in adult renal transplant recipients, but there is a lack of studies on the presence of them in the saliva of paediatric population. Therefore, the objective of this study is to describe oral characteristics and to compare the shedding profile of HSV-1 and EBV in the saliva of children with renal transplant to that of chronic kidney disease patients and controls. METHODS: This is a cross-sectional study involving 100 children, being 25 renal transplant recipients, 25 chronic kidney disease patients and 50 healthy children...
February 6, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29403624/the-effect-of-xerostomia-and-hyposalivation-on-the-quality-of-life-of-patients-with-type-ii-diabetes-mellitus
#14
Tahereh Molania, Mona Alimohammadi, Ozra Akha, Jaber Mousavi, Ramin Razvini, Maedeh Salehi
Background: Diabetes mellitus is a chronic metabolic disease which can have numerous physical effects for patient. Xerostomia is one of these complications. Compared to healthy people, patients with diabetes mellitus, have a worse quality of life, and complications of diabetes are the main determinants of quality of life in these patients. Objective: The aim of this study was to determine the effects of xerostomia and hyposalivation on quality of life of patients with type 2 diabetes mellitus...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29397249/comparison-of-xerostomia-incidence-after-three-dimensional-conformal-radiation-therapy-and-contralateral-superficial-lobe-parotid-sparing-intensity-modulated-radiotherapy-for-oropharyngeal-and-hypopharyngeal-cancer
#15
Terufumi Kawamoto, Keiji Nihei, Yujiro Nakajima, Satoshi Kito, Keisuke Sasai, Katsuyuki Karasawa
OBJECTIVE: In the treatment of head-neck cancer, parotid-sparing intensity-modulated radiotherapy (IMRT) could reduce the incidence of xerostomia. When the parotid glands cannot be sufficiently spared because of the widespread tumor, contralateral superficial lobe parotid-sparing (CSLPS)-IMRT could be used to reduce marginal recurrence, however the success of this approach remains to be determined. The primary purpose of this study was to compare the incidence of xerostomia between three-dimensional conformal radiotherapy (3D-CRT) and CSLPS-IMRT for oropharyngeal and hypopharyngeal cancer...
January 31, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29395443/structured-review-of-the-patient-reported-outcome-instruments-used-in-clinical-trials-in-head-and-neck-surgery
#16
REVIEW
H Boyes, J Barraclough, R Ratansi, S N Rogers, A Kanatas
The number of clinical trials that relate to patients with cancer of the head and neck is growing. Patient-reported outcomes, which are rarely the primary outcome, are now an important component, and in this structured review to identify and report the characteristics of the questionnaires that have been used in these trials, we summarise the findings reported. We searched several online databases using the key terms: head and neck oncology, head and neck surgery, reconstruction, clinical trials patient-reported outcomes, questionnaires, quality of life (QoL), validated instruments, and patients' satisfaction...
January 27, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29394937/side-effects-of-ct-guided-implantation-of-125i-seeds-for-recurrent-malignant-tumors-of-the-head-and-neck-assisted-by-3d-printing-non-co-planar-template
#17
Yuliang Jiang, Zhe Ji, Fuxin Guo, Ran Peng, Haitao Sun, Jinghong Fan, Shuhua Wei, Weiyan Li, Kai Liu, Jinghua Lei, Junjie Wang
BACKGROUND: For the recurrence of head and neck cancer after operation and radiotherapy, the local control of radioactive seed implantation is good, and it has a certain palliative effect. This study aims to investigate the acute and late side effects of a three-dimentional printing non co-planar template (3D-PNCT) for computed tomography (CT)-guided radioactive 125I seed (RIS) implantation in recurrent cancer of the head and neck. METHODS: Between January 2016 and December 2016, forty-two patients with local recurrent malignant tumors of the head and neck received 3D-PNCT-assisted RIS implantation...
February 3, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29391733/a-study-on-evaluation-of-efficacy-of-bethanechol-in-the-management-of-chemoradiation-induced-xerostomia-in-oral-cancer-patients
#18
M Kavitha, K Mubeen, K R Vijayalakshmi
Objectives: Squamous cell carcinoma is the most common oral cancer. Radiotherapy with concomitant chemotherapy is an ideal treatment modality largely used for oral cancers, which precipitates many side effects, of which the most challenging and debilitating side effect is xerostomia. This study aimed to evaluate the efficacy of bethanechol in patients with xerostomia following chemoradiation therapy for oral cancer. Materials and Methods: Fifty patients with xerostomia postchemoradiation therapy, aged between 30 and 65 years, were selected based on selection criteria...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29390256/sjogren-s-syndrome-complicating-pancytopenia-cerebral-hemorrhage-and-damage-in-nervous-system-a-case-report-and-literature-review
#19
Wenqing Yu, Wei Qu, Zhiyong Wang, Chunhong Xin, Rui Jing, Yinghui Shang, Huilin Zou, Hua Wang, Sizhou Feng
RATIONALE: Sjogren's syndrome(SS) is a chronic autoimmune disease, which damages exocrine glands especially salivary and lacrimal glands, with xerostomia and xerophthalmia as common symptoms. PATIENT CONCERNS: We report a case of a 49-year-old woman presented with pancytopenia. Her laboratory examinations lead us diagnose her as Sjogren's syndrome complicating pancytopenia. She had neurological symptoms during her treatment, which represent only 4.5% of Sjogren's syndrome complicating damage in nervous system...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29389481/a-systematic-review-on-chinese-herbal-treatment-for-radiotherapy-induced-xerostomia-in-head-and-neck-cancer-patients
#20
Wan Najbah Nik Nabil, Ren Jye Lim, Si Yan Chan, Nai Ming Lai, Ai Ch'i Liew
BACKGROUND: Over 80% of head and neck cancer patients suffer from radiotherapy-induced xerostomia (dry mouth). Xerostomia affects cancer patients' quality of life, and xerostomia sometimes persists throughout the patients' lifetime. This review aimed to evaluate the effectiveness and safety of Chinese herbs in relieving radiotherapy induced xerostomia. METHODS: Systematic searches were conducted on 6 databases (English and Chinese). Studies published up till May 2017 were considered for inclusion...
February 2018: Complementary Therapies in Clinical Practice
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