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FISH OIL DHA EPA

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https://www.readbyqxmd.com/read/28800645/analysis-of-endogenous-lipids-during-intestinal-wound-healing
#1
Yunna Lee, Jieun Choo, Su Jin Kim, Gwangbeom Heo, Charalabos Pothoulakis, Yong-Hak Kim, Eunok Im
Intestinal wound healing is a new therapeutic goal for inflammatory bowel disease (IBD) as complete healing of the mucosa is the key element of clinical remission in IBD. Previous studies showed that termination of inflammation can be achieved by adding pro-resolving lipids like DHA and EPA exogenously. However, the roles of these lipids in mucosal healing have not been investigated. To recapitulate intestinal healing process, mice were received dextran sodium sulfate (DSS) for 7 days in the drinking water followed by regular tap water for 5 additional days...
2017: PloS One
https://www.readbyqxmd.com/read/28800114/fatty-acid-profile-is-modulated-by-dietary-resveratrol-in-rainbow-trout-oncorhynchus-mykiss
#2
Claudia Torno, Stefanie Staats, Sonia de Pascual-Teresa, Gerald Rimbach, Carsten Schulz
To produce fish of a high quality that are rich in omega-3 fatty acids (n-3 FA) and simultaneously generate more sustainable aquaculture, the combined use of phytochemicals and vegetable oils in fish feed seems to be a promising approach. Resveratrol (RV) potentially induces endogenous fatty acid synthesis, resulting in elevated n-3 FA levels in fish. RV putatively influences ∆6-desaturase, the key enzyme in FA metabolism, and serves as a ligand for PPARα, a transcription factor regulating β-oxidation. Rainbow trout (36...
August 11, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28783061/impact-of-biological-feedback-and-incentives-on-blood-fatty-acid-concentrations-including-omega-3-index-in-an-employer-based-wellness-program
#3
Michael I McBurney, Julia K Bird
Eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3) are important fatty acids for the retina and brain. More than 95% of Americans have suboptimal EPA + DHA blood concentrations. This cross-sectional employer-based study assessed whole blood fatty acid levels of volunteers participating in an onsite wellness biometric screening program and was designed to determine if an incentive, a $5 coupon for a 90-day supply of fish oil supplement typically costing $18-30, stimulated incremental dietary behavior change relative to nutritional status assessment alone to increase EPA + DHA concentrations...
August 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28781788/inhibition-of-pc3-human-prostate-cancer-cell-proliferation-invasion-and-migration-by-eicosapentaenoic-acid-and-docosahexaenoic-acid
#4
Keiichi Oono, Katsuya Takahashi, Saeka Sukehara, Hirohito Kurosawa, Tomio Matsumura, Shun'Ichiro Taniguchi, Shoichiro Ohta
The n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oil, exert a number of beneficial effects, and they are used in the treatment of hyperlipidemia. In recent years, EPA and DHA have been found to affect cancer cell proliferation. In the present study, PC3 cells, which are androgen-independent prostate cancer cells that resemble castration-resistant prostate cancer cells, were used to investigate a possible novel treatment for castration-resistant prostate cancer. The PC3 cells were cultured and incubated with various concentrations of EPA or DHA...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28770178/chemopreventive-and-chemotherapeutic-effects-of-fish-oil-derived-omega-3-polyunsaturated-fatty-acids-on-colon-carcinogenesis
#5
REVIEW
Ja Young Lee, Tae-Bu Sim, Jeong-Eun Lee, Hye-Kyung Na
Colorectal cancer is the third most common cause of cancer related death in the world. Multiple lines of evidence suggest that there is an association between consumption of dietary fat and colon cancer risk. Not only the amount but also the type and the ratio of fatty acids comprising dietary fats consumed have been implicated in the etiology and pathogenesis of colon cancer. Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been known to inhibit development of colon cancer by downregulating the expression of genes involved in colon carcinogenesis and also by altering the membrane lipid composition...
July 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28766116/sardine-oil-loaded-vanillic-acid-grafted-chitosan-microparticles-a-new-functional-food-ingredient-attenuates-myocardial-oxidative-stress-and-apoptosis-in-cardiomyoblast-cell-lines-h9c2
#6
K V Vishnu, K K Ajeesh Kumar, Niladri S Chatterjee, R G K Lekshmi, P R Sreerekha, Suseela Mathew, C N Ravishankar
Fish oil has been widely recognized as an excellent dietary source of polyunsaturated n-3 fatty acids such as EPA and DHA. However, it can undergo oxidation easily resulting in the formation of toxic off flavor compounds such as hydroperoxides. These compounds adversely affect the nutritional quality and may induce several stress reactions in body. To solve this problem, a new antioxidant bio-material, vanillic acid-grafted chitosan (Va-g-Ch), was synthesized and used as a wall material for microencapsulation of fish oil...
August 2, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28763949/physical-and-oxidative-stability-of-fish-oil-in-water-emulsions-fortified-with-enzymatic-hydrolysates-from-common-carp-cyprinus-carpio-roe
#7
Sakhi Ghelichi, Ann-Dorit Moltke Sørensen, Pedro J García-Moreno, Mona Hajfathalian, Charlotte Jacobsen
Physical and oxidative stability of 5% (by weight) cod liver oil-in-water emulsions fortified with common carp (C. carpio) roe protein hydrolysate (CRPH) were examined. CRPH was obtained by enzymatic hydrolysis of discarded roe by using Alcalase 2.4L for 30, 60, 90, and 120min to yield different degrees of hydrolysis (DH). All the hydrolysates showed in vitro antioxidant activity in terms of radical scavenging and chelating properties. CRPH-containing emulsions had significantly smaller droplets than control (p<0...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28758717/epa%C3%A2-%C3%A2-dha-supplementation-reduces-pmn-activation-in-microenvironment-of-chronic-venous-leg-ulcers-a-randomized-double-blind-controlled-study
#8
Jodi C McDaniel, Laura Szalacha, Michelle Sales, Sashwati Roy, Scott Chafee, Narasimham Parinandi
Sustained high levels of activated polymorphonuclear leukocytes (PMNs) and PMN-derived proteases in the microenvironment of chronic venous leg ulcers (CVLUs) are linked to chronic inflammation and delayed healing. Uncontrolled PMN activity eventually destroys newly developed tissue and degrades critical growth factors. The bioactive components of fish oil (n-3 eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) have strong inflammation-resolving actions and have been shown to assuage PMN activity, but have not been tested in CVLU patients...
July 31, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28740349/functional-lipidomics-in-patients-on-home-parenteral-nutrition-effect-of-lipid-emulsions
#9
Loris Pironi, Mariacristina Guidetti, Ornella Verrastro, Claudia Iacona, Federica Agostini, Caterina Pazzeschi, Anna Simona Sasdelli, Michele Melchiorre, Carla Ferreri
AIM: To investigate the fatty acid-based functional lipidomics of patients on long-term home parenteral nutrition receiving different intravenous lipid emulsions. METHODS: A cross-sectional comparative study was carried out on 3 groups of adults on home parenteral nutrition (HPN), receiving an HPN admixture containing an olive-soybean oil-based intravenous lipid emulsion (IVLE) (OO-IVLE; n = 15), a soybean- medium-chain triacylglycerol-olive-fish oil-based IVLE (SMOF-IVLE; n = 8) or HPN without IVLE (No-IVLE; n = 8) and 42 healthy controls (HCs)...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28721723/enrichment-of-long-chain-polyunsaturated-fatty-acids-by-coordinated-expression-of-multiple-metabolic-nodes-in-the-oleaginous-microalga-phaeodactylum-tricornutum
#10
Xiang Wang, Yu-Hong Liu, Wei Wei, Xia Zhou, Wasiqi Yuan, Srinivasan Balamurugan, Ting-Bin Hao, Wei-Dong Yang, Jie-Sheng Liu, Hong-Ye Li
Microalgal long-chain polyunsaturated fatty acids (LC-PUFAs) have emerged as promising alternatives to depleting fish oils. However, the overproduction of LC-PUFAs in microalgae has remained challenging. Here, we report a sequential metabolic engineering strategy that systematically overcomes the metabolic bottlenecks and overproduces LC-PUFAs. Malonyl CoA-acyl carrier protein transacylase, catalyzing the first committed step in type II fatty acid synthesis, and desaturase 5b, involved in fatty acid desaturation, were coordinately expressed in Phaeodactylum tricornutum...
July 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28721583/microbial-and-genetically-engineered-oils-as-replacements-for-fish-oil-in-aquaculture-feeds
#11
REVIEW
M Sprague, M B Betancor, D R Tocher
As the global population grows more of our fish and seafood are being farmed. Fish are the main dietary source of the omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, but these cannot be produced in sufficient quantities as are now required for human health. Farmed fish have traditionally been fed a diet consisting of fishmeal and fish oil, rich in n-3 LC-PUFA. However, the increase in global aquaculture production has resulted in these finite and limited marine ingredients being replaced with sustainable alternatives of terrestrial origin that are devoid of n-3 LC-PUFA...
July 18, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28717347/effect-of-eicosapentaenoic-acids-rich-fish-oil-supplementation-on-motor-nerve-function-after-eccentric-contractions
#12
Eisuke Ochi, Yosuke Tsuchiya, Kenichi Yanagimoto
BACKGROUND: This study investigated the effect of supplementation with fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the M-wave latency of biceps brachii and muscle damage after a single session of maximal elbow flexor eccentric contractions (ECC). METHODS: Twenty-one men were completed the randomized, double-blind, placebo-controlled, and parallel-design study. The subjects were randomly assigned to the fish oil group (n = 10) or control group (n = 11)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28697730/dietary-supplementation-of-%C3%AE-linolenic-acid-induced-conversion-of-n-3-lcpufas-and-reduced-prostate-cancer-growth-in-a-mouse-model
#13
Jingjing Li, Zhennan Gu, Yong Pan, Shunhe Wang, Haiqin Chen, Hao Zhang, Wei Chen, Yong Q Chen
BACKGROUND: α-linolenic acid (ALA) is an n-3 polyunsaturated fatty acid (PUFA) and the substrate for long-chain n-3 PUFAs. The beneficial effects of ALA on chronic diseases are still in dispute, unlike those of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). METHODS: The primary objective of this investigation was to evaluate the efficiency of ALA uptake from a vegetable oil source and its subsequent conversion to n-3 long-chain PUFAs (LCPUFAs) in the tissues of growing mice, and to investigate its protective role in a prostate cancer animal model...
July 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28672788/n-3-polyunsaturated-fatty-acids-decrease-the-protein-expression-of-soluble-epoxide-hydrolase-via-oxidative-stress-induced-p38-kinase-in-rat-endothelial-cells
#14
Takashi Okada, Katsutaro Morino, Fumiyuki Nakagawa, Masashi Tawa, Keiko Kondo, Osamu Sekine, Takeshi Imamura, Tomio Okamura, Satoshi Ugi, Hiroshi Maegawa
N-3 polyunsaturated fatty acids (PUFAs) improve endothelial function. The arachidonic acid-derived metabolites (epoxyeicosatrienoic acids (EETs)) are part of the endothelial hyperpolarization factor and are vasodilators independent of nitric oxide. However, little is known regarding the regulation of EET concentration by docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in blood vessels. Sprague-Dawley rats were fed either a control or fish oil diet for 3 weeks. Compared with the control, the fish oil diet improved acetylcholine-induced vasodilation and reduced the protein expression of soluble epoxide hydrolase (sEH), a key EET metabolic enzyme, in aortic strips...
June 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28664342/effect-of-supplemented-intake-of-omega-3-fatty-acids-on-arrhythmias-in-patients-with-icd-fish-oil-therapy-may-reduce-ventricular-arrhythmia
#15
Dalit Weisman, Roy Beinart, Aharon Erez, Nira Koren-Morag, Ilan Goldenberg, Michael Eldar, Michael Glikson, David Luria
PURPOSE: The aim of this study was to evaluate the effects of fish oils, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on ventricular tachyarrhythmic episodes (VTEs) in implantable cardioverter defibrillator (ICD) recipients with ischemic cardiomyopathy. METHODS: One hundred five ICD recipients with ischemic cardiomyopathy received 3.6 g of EPA and DHA and placebo for 6 months, each at a random order, with a 4-month washout period between treatments...
September 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28601459/in-vitro-response-to-epa-dpa-and-dha-comparison-of-effects-on-ruminal-fermentation-and-biohydrogenation-of-18-carbon-fatty-acids-in-cows-and-ewes
#16
P G Toral, G Hervás, D Carreño, H Leskinen, A Belenguer, K J Shingfield, P Frutos
The modulation of milk fat nutritional quality through fish oil supplementation seems to be largely explained by the action of n-3 very long chain polyunsaturated fatty acids (PUFA) on ruminal biohydrogenation (BH) of C18 fatty acids (FA). However, relationships among this action, disappearance of those PUFA in the rumen, and potential detrimental consequences on ruminal fermentation remain uncertain. This study compared the effect of 20:5n-3 (eicosapentaenoic acid; EPA), 22:5n-3 (docosapentaenoic acid; DPA), and 22:6n-3 (docosahexaenoic acid; DHA) on rumen fermentation and BH of C18 FA and was conducted simultaneously in cows and sheep to provide novel insights into interspecies differences...
June 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28599630/omega-3-supplementation-from-pregnancy-to-postpartum-to-prevent-depressive-symptoms-a-randomized-placebo-controlled-trial
#17
Juliana Dos Santos Vaz, Dayana Rodrigues Farias, Amanda Rodrigues Amorim Adegboye, Antonio Egidio Nardi, Gilberto Kac
BACKGROUND: Low n-3 polyunsaturated fatty acids (PUFAs) has been linked to depression, but the preventive effect of n-3PUFAs supplementation on maternal depression needs further investigation. We aimed to evaluate the efficacy of a daily dose of n-3 PUFAs supplementation (fish oil) on the prevention of postpartum depression (PPD). METHODS: A randomized, placebo-controlled, double blind trial was designed and nested into a cohort study conducted in Rio de Janeiro, Brazil...
June 9, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28598848/synaptic-membrane-synthesis-in-rats-depends-on-dietary-sufficiency-of-vitamin-c-vitamin-e-and-selenium-relevance-for-alzheimer-s-disease
#18
Mehmet Cansev, Mesut Turkyilmaz, John W C Sijben, Cansu Sevinc, Laus M Broersen, Nick van Wijk
Chronic consumption of a diet enriched with nutritional precursors of phospholipids, including uridine and the polyunsaturated fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), was shown previously to enhance levels of brain phospholipids and synaptic proteins in rodents. Vitamin C, vitamin E, and selenium may directly affect the breakdown or synthesis of membrane phospholipids. The present study investigated the necessity of antioxidants for the effectiveness of supplementation with uridine plus DHA and EPA (as fish oil) in rats...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28587463/lipidomics-profiling-of-human-adipose-tissue-identifies-a-pattern-of-lipids-associated-with-fish-oil-supplementation
#19
Elizabeth G Stanley, Benjamin J Jenkins, Celia G Walker, Albert Koulman, Lucy Browning, Annette L West, Philip C Calder, Susan A Jebb, Julian L Griffin
To understand the interaction between diet and health, biomarkers that accurately reflect consumption of foods of perceived health relevance are needed. The aim of this investigation was to use direct infusion-mass spectrometry (DI-MS) lipidomics to determine the effects of fish oil supplementation on lipid profiles of human adipose tissue. Adipose tissue samples from an n-3 polyunsaturated fatty acid (PUFA) supplementation study (n = 66) were analyzed to compare the pattern following supplementation equivalent to zero or four portions of oily fish per week...
August 16, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28587203/effect-of-n-3-polyunsaturated-fatty-acid-supplementation-on-metabolic-and-inflammatory-biomarkers-in-type-2-diabetes-mellitus-patients
#20
M Gorety Jacobo-Cejudo, Roxana Valdés-Ramos, Ana L Guadarrama-López, Rosa-Virgen Pardo-Morales, Beatriz E Martínez-Carrillo, Laurence S Harbige
BACKGROUND: Type 2 diabetes mellitus (T2DM) is accompanied by chronic low-grade inflammation, with an imbalance in the secretion of adipokines and, worsening insulin resistance. Supplementation with n-3 PUFA in T2DM decreases inflammatory markers, the purpose of the study was to investigate the effect of n-3 PUFA supplementation on adipokines, metabolic control, and lipid profile in T2DM Mexican adults. METHODS: In a randomized, single-blind, placebo-controlled pilot study, 54 patients with T2DM received 520 mg of DHA + EPA-enriched fish-oil (FOG) or a placebo (PG) daily...
June 3, 2017: Nutrients
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