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FISH OIL DHA EPA

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https://www.readbyqxmd.com/read/29328808/effective-prevention-of-oxidative-deterioration-of-fish-oil-focus-on-flavor-deterioration
#1
Kazuo Miyashita, Mariko Uemura, Masashi Hosokawa
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), both abundant in fish oil, are known to have significant biochemical and physiological effects primarily linked to the improvement of human health, especially cardiovascular and brain health. However, the incorporation of fish oil into foods and beverages is often challenging, as fish oil is very easily oxidized and can cause undesirable flavors. This review discusses this rapid formation of the fishy and metallic off-flavors, focusing especially on an early stage of fish oil oxidation...
January 12, 2018: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/29316985/cognitive-enhancement-in-old-dogs-from-dietary-supplementation-with-a-nutrient-blend-containing-arginine-antioxidants-b-vitamins-and-fish-oil
#2
Yuanlong Pan, Adam D Kennedy, Thomas J Jönsson, Nortan W Milgram
This study focused on the hypothesis that cognitive decline in aged dogs could be attenuated by dietary supplementation with a nutrient blend consisting of antioxidants, B vitamins, fish oil and l-arginine, referred to hereafter as the Brain Protection Blend (BPB). Baseline cognitive assessment before the start of treatment was used to establish cognitively equivalent control (10·464+2·33 kg) and treatment (12·118+3·386 kg) groups of aged dogs between 9·1 and 11·5 years of age and with body condition score of 5...
January 10, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29305832/all-n-3-pufa-are-not-the-same-md-simulations-reveal-differences-in-membrane-organization-for-epa-dha-and-dpa
#3
Xiaoling Leng, Jacob J Kinnun, Andres T Cavazos, Samuel W Canner, Saame Raza Shaikh, Scott E Feller, Stephen R Wassall
Eicosapentaenoic (EPA, 20:5), docosahexaenoic (DHA, 22:6) and docosapentaenoic (DPA, 22:5) acids are omega-3 polyunsaturated fatty acids (n-3 PUFA) obtained from dietary consumption of fish oils that potentially alleviate the symptoms of a range of chronic diseases. We focus here on the plasma membrane as a site of action and investigate how they affect molecular organization when taken up into a phospholipid. All atom MD simulations were performed to compare 1-stearoyl-2-eicosapentaenoylphosphatylcholine (EPA-PC, 18:0-20:5PC), 1-stearoyl-2-docosahexaenoylphosphatylcholine (DHA-PC, 18:0-22:6PC), 1-stearoyl-2-docosapentaenoylphosphatylcholine (DPA-PC, 18:0-22:5PC) and, as a monounsaturated control, 1-stearoyl-2-oleoylphosphatidylcholine (OA-PC, 18:0-18:1PC) bilayers...
January 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29280361/cardiovascular-disease-and-omega-3s-prescription-products-and-fish-oil-dietary-supplements-are-not-the-same
#4
REVIEW
Adina S Gutstein, Tina Copple
BACKGROUND AND PURPOSE: Despite achievement of optimal low-density lipoprotein cholesterol (LDL-C) control with statin therapy, patients with elevated triglycerides (TGs) and residual cardiovascular risk are commonly encountered in clinical practice. METHODS: We present information from completed and ongoing clinical trials examining Rx omega-3s for TG-lowering and omega-3 dietary supplements to highlight important differences affecting patient management for nurse practitioners...
December 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29232116/two-stage-enzymatic-preparation-of-eicosapentaenoic-acid-epa-and-docosahexaenoic-acid-dha-enriched-fish-oil-triacylglycerols
#5
Zhen Zhang, Fang Liu, Xiang Ma, Huihua Huang, Yong Wang
Fish oil products in the form of triacylglycerols generally have relatively low contents of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and so it is of potential research and industrial interests to enrich related contents in commercial products. Thereby an economical and efficient two-stage preparation of EPA and DHA enriched fish oil triacylglycerols is proposed in this study. The first stage was the partial hydrolysis of fish oil by only 0.2 wt.‰ AY "Amano" 400SD which led to increases of EPA and DHA contents in acylglycerols from 19...
December 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29222893/postprandial-long-chain-n-3-polyunsaturated-fatty-acid-response-to-krill-oil-and-fish-oil-consumption-in-healthy-women-a-randomised-controlled-single-dose-crossover-study
#6
Hyunsin H Sung, Andrew J Sinclair, Paul A Lewandowski, Xiao Q Su
BACKGROUND AND OBJECTIVES: Krill oil (KO) and fish oil (FO) are good sources of health-benefiting long chain n- 3 polyunsaturated fatty acids (LC n-3 PUFA), EPA and DHA. There are conflicting outcomes on the bioavailability of LC n-3 PUFA from KO compared with FO. This study investigated the postprandial incorporation of LC n- 3 PUFA into plasma lipids following consumption of 5 capsules of KO or FO in comparison with olive oil (OO) control in healthy women. METHODS AND STUDY DESIGN: 10 women (aged 18-45 years) consumed a high-fat (15 g) breakfast, supplemented with 5 g of KO, FO, or OO in a random order with a minimum seven-day washout period between the supplementations...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29207553/determination-of-the-relative-efficacy-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-for-anti-cancer-effects-in-human-breast-cancer-models
#7
REVIEW
Laura VanderSluis, Vera C Mazurak, Sambasivarao Damaraju, Catherine J Field
Epidemiological studies have associated high fish oil consumption with decreased risk of breast cancer (BC). n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in fish and fish oils exert anti-cancer effects. However, few studies have examined the relative efficacy of EPA and DHA alone and in mixtures on BC subtypes. This was the objective of the present review, as this research is a necessity for the translation of findings to human health and disease...
December 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29195133/effects-of-fish-oils-on-ex-vivo-b-cell-responses-of-obese-subjects-upon-bcr-tlr-stimulation-a-pilot-study
#8
William Guesdon, Rasagna Kosaraju, Patricia Brophy, Angela Clark, Steve Dillingham, Shahnaz Aziz, Fiona Moyer, Kate Willson, James R Dick, Shivajirao Prakash Patil, Nicholas Balestrieri, Michael Armstrong, Nichole Reisdroph, Saame Raza Shaikh
The long-chain n-3 polyunsaturated fatty acids (LC-PUFAs) eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) in fish oil have immunomodulatory properties. B cells are a poorly studied target of EPA/DHA in humans. Therefore, in this pilot study, we tested how n-3 LC-PUFAs influence B-cell responses of obese humans. Obese men and women were assigned to consume four 1-g capsules per day of olive oil (OO, n=12), fish oil (FO, n=12) concentrate or high-DHA-FO concentrate (n=10) for 12 weeks in a parallel design...
November 2, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29191085/effects-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-on-anxiety-like-behavior-in-socially-isolated-rats
#9
Yasuyo Oshima, Tasuku Watanabe, Shun Endo, Shuichi Hata, Tsuyoshi Watanabe, Kyoichi Osada, Asako Takenaka
The effects of fish oil for improving mental health have been reported. The present study was undertaken to compare the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on anxiety-like behavior using a rat model. Experimental diets enriched in EPA or DHA as glycerides were prepared. Rats were exposed to social isolation stress and fed the experimental diet for 14 days. The results of behavioral tests revealed that rats fed the EPA-enriched diet exhibited less anxiety-like behavior than rats fed the control or DHA-enriched diets...
December 1, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29186929/integrated-immunomodulatory-mechanisms-through-which-long-chain-n-3-polyunsaturated-fatty-acids-attenuate-obese-adipose-tissue-dysfunction
#10
REVIEW
Danyelle M Liddle, Amber L Hutchinson, Hannah R Wellings, Krista A Power, Lindsay E Robinson, Jennifer M Monk
Obesity is a global health concern with rising prevalence that increases the risk of developing other chronic diseases. A causal link connecting overnutrition, the development of obesity and obesity-associated co-morbidities is visceral adipose tissue (AT) dysfunction, characterized by changes in the cellularity of various immune cell populations, altered production of inflammatory adipokines that sustain a chronic state of low-grade inflammation and, ultimately, dysregulated AT metabolic function. Therefore, dietary intervention strategies aimed to halt the progression of obese AT dysfunction through any of the aforementioned processes represent an important active area of research...
November 27, 2017: Nutrients
https://www.readbyqxmd.com/read/29181705/coenzyme-q10-loaded-fish-oil-based-bigel-system-probing-the-delivery-across-porcine-skin-and-possible-interaction-with-fish-oil-fatty-acids
#11
Mohd Hanif Zulfakar, Lee Mei Chan, Khurram Rehman, Lam Kok Wai, Charles M Heard
Coenzyme Q10 (CoQ10) is a vitamin-like oil-soluble molecule that has anti-oxidant and anti-ageing effects. To determine the most optimal CoQ10 delivery vehicle, CoQ10 was solubilised in both water and fish oil, and formulated into hydrogel, oleogel and bigel. Permeability of CoQ10 from each formulation across porcine ear skin was then evaluated. Furthermore, the effects of the omega-3 fatty eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids from fish oil on skin permeation were investigated by means of nuclear magnetic resonance (NMR) and computerised molecular modelling docking experiments...
November 27, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29171642/dietary-supplements-for-cognitive-impairment
#12
Javier Olivera-Pueyo, Carmelo Pelegrín-Valero
Alzheimer disease and the other neurodegenerative dementias as yet have no curative treatment. For this reason, the prevention of these conditions and non-pharmacological treatments are important fields of research at present. The Mediterranean diet (rich in fruits, vegetables, legumes, and olive oil, with regular fish consumption and low consumption of dairy products and meats) has been shown to reduce the incidence of mild cognitive impairment (MCI) and, probably, the conversion of MCI to dementia. Vitamins, especially vitamin E and the vitamins of the B group, have also been associated with the prevention of cognitive impairment due to their antioxidant effects...
September 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29163147/chronic-psychological-stress-was-not-ameliorated-by-omega-3-eicosapentaenoic-acid-epa
#13
Joanne Bradbury, Stephen P Myers, Barbara Meyer, Lyndon Brooks, Jonathan Peake, Andrew J Sinclair, Con Stough
Background: Chronic psychological stress and mental health disorders are endemic in Western culture where population dietary insufficiencies of omega-3 fatty acids (n-3FA) from seafood have been observed. Objective: This study was designed to test for a causal relationship between one of the most active components of fish oil, eicosapentaenoic acid (EPA), and chronic psychological stress. Method: A randomized double-blind, placebo-controlled clinical trial with parallel-assignment to two groups was designed (Trial Id: ACTRN12610000404022)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29156325/differential-partitioning-of-rumen-protected-n-3-and-n-6-fatty-acids-into-muscles-with-different-metabolism
#14
C Wolf, S E Ulbrich, M Kreuzer, J Berard, K Giller
Bioavailability of polyunsaturated fatty acids (PUFA) in ruminants is enhanced by their protection from ruminal biohydrogenation. Both n-3 and n-6 PUFA fulfil important physiological functions. We investigated potentially different incorporation patterns of these functional PUFA into three beef muscles with different activity characteristics. We supplemented 33 Angus heifers with rumen-protected oils characterized either by mainly C18:2 n-6 (linoleic acid (LA) in sunflower oil) or by C20:5 (eicosapentaenoic acid (EPA)) and C22:6 (docosahexaenoic acid (DHA)), both prevalent n-3 PUFA in fish oil...
November 6, 2017: Meat Science
https://www.readbyqxmd.com/read/29152241/effects-of-matrix-on-plasma-levels-of-epa-and-dha-in-dogs
#15
Kay Goffin, Marc van Maris, Ronald J Corbee
EPA and DHA are often used in veterinary medicine due to their beneficial effects for several medical conditions such as osteoarthritis. EPA and DHA are administered to dogs through different matrices. The aim of the present study was to determine the effects on the plasma levels in dogs caused by various matrices for EPA and DHA administration. In this study, three different n-3 PUFA formulations were used: soft chew tablet (CCx); liquid fish oil (LFO); and enriched kibbles (EK). The formulations were administered single-dose and compared in a randomised, cross-over designed study with a 1-week wash-out period...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29142166/fish-oil-feeding-reverses-hepatomegaly-and-disrupted-hepatic-function-due-to-the-lack-of-fxr-signaling
#16
Masaaki Miyata, Kouhei Shinno, Tomoki Kinoshita, Yuichi Kinoshita, Yoshimasa Sugiura
Mice lacking farnesoid X receptor (FXR) are used as a model for nonalcoholic fatty liver disease because their livers exhibit hepatomegaly, hepatic steatosis, and hepatic inflammation. The influence of fish oil feeding on hepatomegaly and disrupted hepatic function was investigated using female Fxr-null mice and wild-type mice fed a fish oil diet (2% fish oil and 2% corn oil) or a control diet (4% corn oil) for 4 weeks. Hepatic n-3 polyunsaturated fatty acid (PUFA) levels, including 22:6 n-3 docosahexaenoic acid (DHA) and 20:5 n-3 eicosapentaenoic acid (EPA) were significantly higher in the fish oil group than those in the control group of Fxr-null mice and wild-type mice...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29121093/fish-oil-omega-3-polyunsaturated-fatty-acids-attenuate-oxidative-stress-induced-dna-damage-in-vascular-endothelial-cells
#17
Chiemi Sakai, Mari Ishida, Hideo Ohba, Hiromitsu Yamashita, Hitomi Uchida, Masao Yoshizumi, Takafumi Ishida
OBJECTIVE: Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), likely prevent cardiovascular disease, however their mechanisms remain unclear. Recently, the role of DNA damage in atherogenesis has been receiving considerable attention. Here, we investigated the effects of EPA and DHA on DNA damage in vascular endothelial cells to clarify their antiatherogenic mechanisms. METHODS AND RESULTS: We determined the effect of EPA and DHA on H2O2-induced DNA damage response in human aortic endothelial cells...
2017: PloS One
https://www.readbyqxmd.com/read/29113108/polymorphisms-in-ffar4-gpr120-gene-modulate-insulin-levels-and-sensitivity-after-fish-oil-supplementation
#18
Bastien Vallée Marcotte, Hubert Cormier, Iwona Rudkowska, Simone Lemieux, Patrick Couture, Marie-Claude Vohl
The objective was to test whether FFAR4 single nucleotide polymorphisms (SNPs) are associated with glycemic control-related traits in humans following fish oil supplementation. A total of 210 participants were given 3 g/day of omega-3 (n-3) fatty acids (FA) (1.9-2.2 g of eicosapentaenoic acid (EPA) and 1.1 g of docosahexaenoic acid (DHA)) during six weeks. Biochemical parameters were taken before and after the supplementation. Using the HapMap database and the tagger procedure in Haploview, 12 tagging SNPs in FFAR4 were selected and then genotyped using TaqMan technology...
November 6, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29098469/supplementation-of-arachidonic-acid-rich-oil-in-european-sea-bass-juveniles-dicentrarchus-labrax-diets-effects-on-growth-performance-tissue-fatty-acid-profile-and-lipid-metabolism
#19
S Torrecillas, M B Betancor, M J Caballero, F Rivero, L Robaina, M Izquierdo, D Montero
The aim of this study was to evaluate the effects of increasing dietary arachidonic acid (ARA) levels (from 1 to 6% of total fatty acids) on European sea bass (Dicentrarchus labrax) juveniles' growth performance, tissue fatty acid profile, liver morphology as well as long-chain polyunsaturated fatty acids (LC-PUFA) biosynthesis, triglyceride and cholesterol synthesis and lipid transport. A diet with total fish oil (FO) replacement and defatted fish meal (FM) containing a 0.1-g ARA g(-1) diet was added to the experimental design as a negative control diet...
November 2, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29095488/antigastric-cancer-bioactive-aurantiochytrium-oil-rich-in-docosahexaenoic-acid-from-media-optimization-to-cancer-cells-cytotoxicity-assessment
#20
Shahryar Shakeri, Neda Amoozyan, Farzaneh Fekrat, Mahmood Maleki
Dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may have a role in contributing to the prevention or inhibition of some malignancies. DHA, the most important polyunsaturated fatty acid (PUFA) in fish and thraustochytrid oils, is known for its anticancer activity. However, antigastric cancer activity of thraustochytrid microbial oil is still unclear. In this investigation, 45 thraustochytrid strains were screened for the production of antigastric cancer oil. Cytotoxicity of 12 thraustochytrid oils was assessed by 3-(4,5-dimethythiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) on gastric cancer AGS cells...
November 2, 2017: Journal of Food Science
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