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CB2 synuclein

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https://www.readbyqxmd.com/read/27063942/targeting-the-cannabinoid-cb2-receptor-to-attenuate-the-progression-of-motor-deficits-in-lrrk2-transgenic-mice
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Cristina Palomo-Garo, Yolanda Gómez-Gálvez, Concepción García, Javier Fernández-Ruiz
Most of cases of Parkinson's disease (PD) have a sporadic origin, with their causes mostly unknown, although overexposure to some environmental factors has been found to occur in some cases. Other forms of parkinsonism are the consequence of dominant or recessive mutations in specific genes, e.g. α-synuclein, parkin and, more recently, leucine-rich repeat kinase 2 (LRRK2), whose G2019S mutation represents the most prevalent form of late-onset, autosomal dominant familial PD. A transgenic mouse model expressing the G2019S mutation of LRRK2 is already available and apparently may represent a valuable experimental model for investigating PD pathogenesis and novel treatments...
August 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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