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https://www.readbyqxmd.com/read/28304112/evaluation-of-various-approaches-to-the-isolation-of-steroid-hormones-from-urine-samples-prior-to-fass-mekc-analysis
#1
Ilona Olędzka, Piotr Kowalski, Alina Plenis, Tomasz Bączek
The goal of this study was to assess various analytical approaches for the simultaneous and efficient extraction of steroid hormones (cortisone, cortisol, prednisolone, corticosterone, testosterone, 17α-methyltestosterone, epitestosterone, progesterone) from urine samples prior to separation based on field-amplified sample stacking-micellar electrokinetic chromatography (FASS-MEKC). FASS-MEKC successfully allowed the compounds to be separated within 12 min using a background electrolyte (BGE) comprised of 5 mM sodium tetraborate, 150 mM boric acid, 50 mM SDS and 15% methanol...
March 17, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28253299/combinatorial-effects-of-quercetin-and-sex-steroids-on-fluid-and-electrolytes-na-cl-hco3-secretory-mechanisms-in-the-uterus-of-ovariectomised-female-sprague-dawley-rats
#2
Huma Shahzad, Nelli Giribabu, Kamarulzaman Karim, Normadiah M Kassim, Sekaran Muniandy, Naguib Salleh
Dysregulation of uterine fluid environment could impair successful reproduction and this could be due to the effect of environmental estrogens. Therefore, in this study, effect of quercetin, an environmental estrogen on uterine fluid and electrolytes concentrations were investigated under sex-steroid influence. Ovariectomised adult female Sprague-Dawley rats were given 10, 50 or 100mg/kg/day quercetin subcutaneously with 17-β estradiol (E) for seven days or three days E, then three days E plus progesterone (P) (E+P) treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28184376/seronegative-adult-autoimmune-enteropathy-in-a-male-traveler
#3
Patrick McCabe, Latifat Alli-Akintade, Jesse Stondell
Autoimmune enteropathy (AIE) is rare but damaging. The lack of consistent objective findings makes diagnosis a challenge. A 45-year-old male developed noninfectious diarrhea with significant weight loss and electrolyte abnormalities. Computed tomography delineated enteritis. Colonoscopy and esophagogastroduodenoscopy showed villous atrophy, chronic inflammation, and ulceration of the terminal ileum and cecum. Pathology showed cryptitis with apoptosis and abscesses throughout the small and large bowel and absent goblet cells...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28089738/evaluation-of-the-diuretic-activity-of-the-aqueous-and-80-methanol-extracts-of-the-root-of-euclea-divinorum-hiern-ebenaceae-in-sprague-dawley-rats
#4
Beharu Woldemedhin, Teshome Nedi, Workineh Shibeshi, Mekonnen Sisay Shiferaw
BACKGROUND: Diuretics are drugs that increase the formation of urine and are important for the treatment of various diseases including hypertension and edema. The root decoction of Euclea divinorum has been used as a diuretic agent in the traditional medicine. Therefore, this study was aimed to evaluate the diuretic activity of the crude extracts of the roots of Euclea divinorum in Sprague Dawley rats. METHODS: The aqueous extract (AE) and 80% methanol extract (80ME) of the plant were prepared using decoction and maceration, respectively...
January 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28073136/-proton-pump-inhibitor-side-effects-and-complications-of%C3%A2-long-term-proton-pump-inhibitor-administration
#5
Hendrik Ueberschaer, Hans-Dieter Allescher
Proton Pump Inhibitors are among the most common drugs taken. The indication is for treatment of heartburn, reflux disease, prophylaxis and treatment of peptic ulcers, in combination with NSAIDs and steroids as well as H. pylori-eradication. PPI's are widely used, even with non-specific symptoms. This certainly has to do with good tolerability and a previously considered low side effect profile. At the moment, there is growing evidence that the long-term intake of PPI's may not be as safe as assumed. In addition to interactions with some drugs, including platelet aggregation inhibitors, recent studies have shown an increased risk of myocardial infarction, interstitial nephritis, chronic renal injury, infections, vitamin deficiencies and electrolyte shifts as well developing dementia...
January 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27959876/degradation-of-gestodene-ges-17%C3%AE-ethinylestradiol-ee2-mixture-by-electrochemical-oxidation
#6
Hugo Alejandro Nájera-Aguilar, Rubén Fernando Gutiérrez-Hernández, Rocío González de Los Santos, Carlos García-Lara, Roger Méndez-Novelo, María Neftalí Rojas-Valencia
Evidence of the negative effects of several pharmaceutical molecules, such as hormones and steroids, on the environment can be observed throughout the world. This paper presents the results of the anodic oxidation of the mixture of gestodene steroid hormones and 17 α-ethinylestradiol present in aqueous medium. The tests were conducted in an undivided cell containing a working volume of 50 mL, using a Na2SO4 solution as support electrolyte and boron-doped diamond electrodes. The experiments were adjusted to the structure of a 3(3) factorial design...
December 2016: Journal of Water and Health
https://www.readbyqxmd.com/read/27932336/heat-stress-hydration-and-uric-acid-a-cross-sectional-study-in-workers-of-three-occupations-in-a-hotspot-of-mesoamerican-nephropathy-in-nicaragua
#7
Catharina Wesseling, Aurora Aragón, Marvin González, Ilana Weiss, Jason Glaser, Christopher J Rivard, Carlos Roncal-Jiménez, Ricardo Correa-Rotter, Richard J Johnson
OBJECTIVES: To study Mesoamerican nephropathy (MeN) and its risk factors in three hot occupations. DESIGN: Cross-sectional. SETTING: Chinandega and León municipalities, a MeN hotspot on the Nicaraguan Pacific coast, January-February 2013. PARTICIPANTS: 194 male workers aged 17-39 years: 86 sugarcane cutters, 56 construction workers, 52 small-scale farmers. OUTCOME MEASURES: (1) Differences between the three occupational groups in prevalences/levels of socioeconomic, occupational, lifestyle and health risk factors for chronic kidney disease (CKD) and in biomarkers of kidney function and hydration; (2) differences in prevalences/levels of CKD risk factors between workers with reduced estimated glomerular filtration rate (eGFRCKD-EPI <80 mL/min/1...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27920706/ipilimumab-induced-enteritis-without-colitis-a-new-challenge
#8
Marcus Messmer, Sunita Upreti, Yaman Tarabishy, Nikhilesh Mazumder, Reezwana Chowdhury, Mark Yarchoan, Matthias Holdhoff
INTRODUCTION: Ipilimumab is an immune checkpoint inhibitor targeting cytotoxic T-lymphocyte associated antigen 4 (CTLA4), approved to treat metastatic melanoma. It was the first therapy shown to prolong survival in a large, randomized clinical trial. However, immune-related adverse events are common and can be severe. Enterocolitis is a common adverse event with ipilimumab, but enteritis without colitis has not been previously described. CASE REPORT: An 83-year-old man presented to our hospital with grade 3 diarrhea for 5 days...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27897427/structure-based-drug-design-of-mineralocorticoid-receptor-antagonists-to-explore-oxosteroid-receptor-selectivity
#9
Anneli Nordqvist, Gavin O'Mahony, Maria Fridén-Saxin, Marlene Fredenwall, Anders Hogner, Kenneth L Granberg, Anna Aagaard, Stefan Bäckström, Anders Gunnarsson, Tim Kaminski, Yafeng Xue, Anita Dellsén, Eva Hansson, Pia Hansson, Ida Ivarsson, Ulla Karlsson, Krister Bamberg, Majlis Hermansson, Jennie Georgsson, Bo Lindmark, Karl Edman
The mineralocorticoid receptor (MR) is a nuclear hormone receptor involved in the regulation of body fluid and electrolyte homeostasis. In this study we explore selectivity triggers for a series of nonsteroidal MR antagonists to improve selectivity over other members of the oxosteroid receptor family. A biaryl sulfonamide compound was identified in a high-throughput screening (HTS) campaign. The compound bound to MR with pKi =6.6, but displayed poor selectivity over the glucocorticoid receptor (GR) and the progesterone receptor (PR)...
November 29, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27875951/effect-of-supraphysiological-doses-of-nandrolone-decanoate-upon-aldosterone-concentration-and-serum-na-k-levels-in-albino-mice
#10
Parmita Chowdhury, Rita Mahanta
BACKGROUND: This article is a study of adverse effects associated with the abuse of recreational drugs such as Anabolic Androgenic Steroids. Nandrolone Decanoate is one such drug often abused by athletes and bodybuilders seeking enhanced physical strength or appearance. The use of such steroids has increased dramatically over the years. OBJECTIVE: The present study was conducted to investigate the impact of nandrolone decanoate when consumed at an abused dose, upon serum aldosterone concentration in albino mice...
November 21, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27857783/hyponatremia-in-children-with-tuberculous-meningitis-a-hospital-based-cohort-study
#11
Prithi Inamdar, Sanjeevani Masavkar, Preeti Shanbag
BACKGROUND: Hyponatremia has long been recognized as a potentially serious metabolic consequence of tuberculous meningitis (TBM) occurring in 35-65% of children with the disease. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has for long been believed to be responsible for the majority of cases of hyponatremia in TBM. Cerebral salt wasting syndrome (CSWS) is being increasingly reported as a cause of hyponatremia in some of these children. AIM: This study was done to determine the frequency and causes of hyponatremia in children with TBM...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27763627/human-intestinal-barrier-function-in-health-and-disease
#12
REVIEW
Julia König, Jerry Wells, Patrice D Cani, Clara L García-Ródenas, Tom MacDonald, Annick Mercenier, Jacqueline Whyte, Freddy Troost, Robert-Jan Brummer
The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a tight barrier against the ingress of harmful substances, and protect against a reaction to omnipresent harmless compounds. A dysfunctional intestinal barrier is associated with various diseases and disorders. In this review, the role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease, irritable bowel syndrome, obesity, celiac disease, non-celiac gluten sensitivity, and food allergies will be discussed...
October 20, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27760997/mineralocorticoid-receptor-as-a-therapeutic-target-in-chronic-kidney-disease-and-hypertension
#13
REVIEW
Shigeru Shibata, Kenichi Ishizawa, Shunya Uchida
The kidney has a central role in long-term control of blood pressure, and decreased kidney function is a common but difficult-to-treat cause of hypertension. Conversely, elevated blood pressure contributes to the progression of chronic kidney disease. Steroid hormone aldosterone and its receptor mineralocorticoid receptor (MR) contribute to hypertension by increasing renal salt reabsorption and promote kidney dysfunction through direct effects on renal parenchymal cells. Accumulating data indicate that various mechanisms affect aldosterone-MR signaling...
October 20, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27596103/current-treatment-options-for-early-onset-pediatric-epileptic-encephalopathies
#14
REVIEW
Rolla Shbarou
The management of early-onset, genetically determined epilepsies is often challenging. First-line anti-epileptic drugs (AEDs) often include phenobarbital, phenytoin, oxcarbazepine, carbamazepine, clonazepam, levetiracetam, and valproic acid. Combinations of medications are used in these patients with often intractable seizures, and they include topiramate, clobazam, felbamate, lacosamide, lamotrigine, rufinamide, vigabatrin, ACTH, oral steroids, and the ketogenic diet. Vagus nerve stimulator therapy offers some relief in selected patients...
October 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27494223/prevalence-and-implications-of-abnormal-laboratory-results-in-patients-in-the-terminal-phase-of-life
#15
Anniek D Masman, Dick Tibboel, Frans P M Baar, Monique van Dijk, Ron A A Mathot, Teun van Gelder
BACKGROUND: Pathophysiological changes at the end of life may affect pharmacokinetics of drugs. However, caregivers typically do not extensively monitor patients' laboratory parameters at the end of life. OBJECTIVE: Our aim was to describe laboratory parameters of hospice patients in the week before death. METHODS: A cohort study was conducted on available laboratory results in the week before death, including clinical chemistry and hematology tests...
August 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27485500/congenital-primary-adrenal-insufficiency-and-selective-aldosterone-defects-presenting-as-salt-wasting-in-infancy-a-single-center-10-year-experience
#16
Carla Bizzarri, Nicole Olivini, Stefania Pedicelli, Romana Marini, Germana Giannone, Paola Cambiaso, Marco Cappa
BACKGROUND: Salt-wasting represents a relatively common cause of emergency admission in infants and may result in life-threatening complications. Neonatal kidneys show low glomerular filtration rate and immaturity of the distal nephron leading to reduced ability to concentrate urine. METHODS: A retrospective chart review was conducted for infants hospitalized in a single Institution from 1(st) January 2006 to 31(st) December 2015. The selection criterion was represented by the referral to the Endocrinology Unit for hyponatremia (serum sodium <130 mEq/L) of suspected endocrine origin at admission...
August 2, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27466399/chronic-exposure-of-adult-postnatal-and-in-utero-rat-models-to-low-dose-137cesium-impact-on-circulating-biomarkers
#17
Line Manens, Stéphane Grison, Jean-Marc Bertho, Philippe Lestaevel, Yann Guéguen, Marc Benderitter, Jocelyne Aigueperse, Maâmar Souidi
The presence of (137)Cesium ((137)Cs) in the environment after nuclear accidents at Chernobyl and more recently Fukushima Daiichi raises many health issues for the surrounding populations chronically exposed through the food chain. To mimic different exposure situations, we set up a male rat model of exposure by chronic ingestion of a (137)Cs concentration likely to be ingested daily by residents of contaminated areas (6500 Bq.l(-1)) and tested contaminations lasting 9 months for adult, neonatal and fetal rats...
November 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27351488/identification-of-risk-factors-for-intravenous-infiltration-among-hospitalized-children-a-retrospective-study
#18
Soon Mi Park, Ihn Sook Jeong, Seong Sook Jun
This retrospective study was aimed to identify risk factors of intravenous (IV) infiltration for hospitalized children. The participants were 1,174 children admitted to a general hospital, who received peripheral intravenous injection therapy at least once, and had complete records. Data were analyzed with frequency and percentage or mean and standard deviation were calculated, and odds ratio (OR) from univariate and multiple logistic regressions. The number and % of infiltrations were 92 and 7.8%, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27267220/initial-manifestation-of-type-i-diabetes-mellitus-as-an-unusual-cause-of-early-post-operative-seizures
#19
Barbora Benova, Pavel Krsek, Zdenek Sumnik, Martin Kudr, Vladimir Komarek, Michal Tichy
We present a case of an 18-year-old patient who underwent resective epilepsy surgery for intractable epilepsy caused by focal cortical dysplasia. In the early post-surgical period, the patient started experiencing atypical seizures refractory to antiepileptic treatment. In due course, abnormally low levels of blood sodium and extremely high levels of blood glucose were discovered. Significant hyperglycaemia was initially ascribed to steroid-induced diabetes, and antibodies specific to type I diabetes mellitus were subsequently detected, confirming the diagnosis...
June 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27244796/a-17-year-old-with-steroid-resistant-nephrotic-syndrome
#20
Molly E Band, Candice Sheldon, John Brancato, Nehal S Parikh, Cynthia D'Alessandri-Silva
A 17-year-old girl presented with facial swelling and shortness of breath to an outside emergency department. She was treated for an allergic reaction with steroids and antihistamines, and discharged from the hospital. Subsequently, she was referred as an outpatient to pediatric nephrology for recurrent edema and proteinuria. Initial laboratory workup by nephrology was significant for a normal complete blood count and reassuring electrolyte panel. Pertinent laboratories were a creatinine of 0.5 mg/dL (0.4-1...
May 2016: Pediatrics
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