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Dry eye treatment

Natasha Ferreira Santos da Cruz, Larissa Silva Brandão, Sérgio Ferreira Santos da Cruz, Sérgio Augusto Sequeira da Cruz, Carla Andréa Avelar Pires, Francisca Regina Oliveira Carneiro
PURPOSE: We aimed to report the ocular manifestations observed in patients with psoriasis. METHODS: Patients were included and referred to our ophthalmology clinic from dermatology clinics of Universidade do Estado do Pará between October 2013 and August 2014. Clinical interviews were conducted to identify relevant epidemiological data, clinical features, and treatment details, and data were recorded using the same protocol. Subsequent dermatological examinations were performed and disease severity was rated using the Psoriasis Area and Severity Index and the Dermatological Life Quality Index...
June 2018: Arquivos Brasileiros de Oftalmologia
Dario Rusciano, Salvatore Pezzino, Melania Olivieri, Martina Cristaldi, Caterina Gagliano, Gabriella Lupo, Carmelina Daniela Anfuso
Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex (being more frequent among women) and age (increasing with aging). Therefore, specific treatments taking into account the etiology of the disease would be desired. The role of lactoferrin and its functional mimetic lactobionic acid are reported here as a possible remedy for age-related dry eye...
June 19, 2018: Ophthalmic Research
Alfonso Vasquez-Perez, Francesco Matarazzo, Niraj Mandal, Stephen Tuft
PURPOSE: To describe a case of acute glaucoma after cyanoacrylate gluing for a non-traumatic central corneal perforation. METHODS: A 55-year-old woman with history of rheumatoid arthritis and severe dry eye presented to emergency with a right central corneal perforation. She was treated successfully with the use cyanoacrylate glue patch but iridocorneal adhesions remained. The next day she presented with ocular pain, headaches and vomiting. On examination she had shallow anterior chamber with no aqueous leakage but her intraocular pressure was 56▒mm Hg measured with rebound tonometry...
June 18, 2018: Journal of Glaucoma
X Yang, Y Li
Objective: To evaluate the short-term efficacy and psycological influence of elastic silicon punctal plugs on severe dry eye patients. Methods: Prospective case series study. Twenty-eight severe dry eye patients (56 eyes) treated with elastic silicon punctal plugs (Snug Plugs(TM), FCI Ophthalmics, France) during January to September 2017 at the ophthalmology department of Peking Union Medical College Hospital were included. All the examination results were collected at baseline and 3 months after insertion...
June 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Z G Liu, W Li
Dry eye has become the most common ocular surface disease in China's clinical ophthalmology. However, dry eye in children has not achieved enough attention. It lacks related information of basic data and diagnostic criteria, and there is no standard for the clinical diagnosis and treatment. As dry eye in children has its own characteristics, its diagnosis and treatment are not exactly the same as adults. In recent years, due to the popularization and widespread usage of electronic products, coupled with some systemic factors, the incidence of dry eye in children has risen rapidly...
June 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Leila Etemad, Mohammad Moshiri, Mahdi Balali-Mood
The present study aimed to review and discuss the recommended and recently suggested protocols by Iranian researchers for a long-term treatment of delayed complications of sulfur mustard (DCSM) in veterans. As indicated clinically, patients who suffer from delayed ocular complications of sulfur mustard (DOCS) benefit from treatments for dry eyes, therapeutic contact lenses, amniotic membrane transplantation; blepharorrhaphy, tarsorrhaphy, limbal stem cell transplantation; corneal transplantation, topical steroids, and immunosuppressive...
May 2018: Iranian Journal of Medical Sciences
Sayan Basu, Ritu Nagpal, Juan Carlos Serna-Ojeda, Swapnil Bhalekar, Bhupesh Bagga, Virender Sangwan
PURPOSE: To describe the anatomical and functional outcomes of the novel LVP keratoprosthesis (Kpro), developed as an alternative to the modified osteo-odonto keratoprosthesis (MOOKP), in eyes with end-stage corneal blindness where conventional corneal surgeries are contraindicated. METHODS: This prospective case series included 58 eyes of 56 patients (12 children and 44 adults) with severe bilateral keratopathy and completely dry, dermalised ocular surfaces who underwent unilateral LVP Kpro implantation from 2012 to 2016...
June 11, 2018: British Journal of Ophthalmology
Tomoya Nakamachi
Dry eye syndrome is defined as a disorder of the tear film caused by either a decreased production in tears or a disruption to the stability of the complex tear film, which causes damage to the ocular surface. It has been developed the medicine for dry eye syndrome focusing anti-inflammation or mucin secretion, however, no treatment has been developed focusing on the effect of elevation of the lacrimal secretion. We recently identified that pituitary adenylate cyclase-activating polypeptide (PACAP)-null mice develop dry eye-like symptoms such as corneal keratinization and tear reduction...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
David H W Steel, Javid Suleman, Declan C Murphy, Anna Song, Steve Dodds, Jon Rees
PURPOSE: To identify the incidence, presenting features, treatment, and clinical course of optic disc pit maculopathy (ODPM) in the United Kingdom (UK). DESIGN: A 2-year nationwide prospective population-based study. SUBJECTS: All new incident cases of ODPM presenting to UK ophthalmologists using the British Ophthalmic Surveillance Unit monthly reporting system. METHODS: All reporting ophthalmologists were sent an initial questionnaire requesting data on previous medical and ophthalmic history, presentation details, investigation findings, and management...
June 7, 2018: Ophthalmology
Ronald Mauricio Sanchez-Avila, Jesus Merayo-Lloves, Maria Laura Fernandez, Luis Alberto Rodriguez-Gutierrez, Nancy Jurado, Francisco Muruzabal, Gorka Orive, Eduardo Anitua
PURPOSE: The aim of this study was to evaluate the use of plasma rich in growth factors (PRGF) eye drops in patients with dry eye disease after laser-assisted in situ keratomileusis (LASIK) surgery. MATERIAL AND METHODS: This is a longitudinal, retrospective, comparative, and descriptive study of 77 eyes of 42 patients with dry eye disease following LASIK surgery. This study was designed to evaluate the efficacy of PRGF treatment compared to conventional therapy (control group)...
June 8, 2018: Ophthalmic Research
Penny A Asbell, Maureen G Maguire, Ellen Peskin, Vatinee Y Bunya, Eric J Kuklinski
PURPOSE: Describe trial design and baseline characteristics of participants in the DRy Eye Assessment and Management (DREAM©) Study. DESIGN: Prospective, multi-center, randomized, double-masked "real-world" clinical trial assessing efficacy and safety of oral omega-3 (ω3) supplementation for the treatment of dry eye disease (DED). METHODS: RESULTS: Mean age of participants was 58.0 ± 13.2 years. Mean OSDI score at baseline was 44...
June 5, 2018: Contemporary Clinical Trials
Seong-Min Kweon, Jung Hee Koh, Han-Na Lee, Eunsung Kim, Min Wook So, Ho-Jin Shin, Hee Young Choi, Seung-Geun Lee
INTRODUCTION: Amyloidosis accompanied by Sjögren's syndrome (SS) has been reported to occur primarily in the skin, lungs, tongue, and mammary gland. However, SS in association with secondary amyloidosis is rarely reported, and knowledge of its relevance is inadequate. Here we report a case of primary SS diagnosed simultaneously with localized amyloidosis of the lacrimal gland. CASE PRESENTATION: A 45-year-old woman complaining of a left eyelid mass was referred to the hospital and was diagnosed with localized amyloidosis after excisional biopsy...
June 2018: Medicine (Baltimore)
Xue Zhang, Zhishun Liu, Wentao Ding, Jun Zhang, Huan Shi, Wenzeng Zhu
BACKGROUND: Dry eye disease (DED) is a very common disease. Although several current treatments offer some symptomatic relief, moderate to severe DED is still difficult to cure at present. Acupuncture may be effective for DED via its promotion of tear secretion and ability to improve symptoms, but evidence of its effectiveness is limited. The aim of this study is to evaluate the effect of acupuncture versus artificial tears in moderate to severe DED. METHODS/DESIGN: A total of 120 participants with moderate to severe DED will be randomly assigned to either an acupuncture group or an artificial tear group at a ratio of 1:1...
June 2018: Medicine (Baltimore)
Wen-Long Hu, Pei-Chang Wu, Li-Yen Pan, Hun-Ju Yu, Chih-Chin Pan, Yu-Chiang Hung
BACKGROUND: Dry eye is a common ophthalmologic disorder that causes ocular discomfort and has become a worldwide health concern. Patients with dry eye often turn to complementary and alternative medicine (CAM) because of unsatisfactory conventional treatments. Acupuncture is one of the most popular interventions of CAM used, and laser acupuncture (LA) is a noninvasive technique. METHODS: This protocol is a 2-center randomized controlled trial investigating the effect of laser acupuncture on dry eye...
June 2018: Medicine (Baltimore)
Ren-Wen Ho, Po-Chiung Fang, Tsai-Ling Chao, Chun-Chih Chien, Ming-Tse Kuo
The aim of this study was to investigate changes in the tear film lipid layer thickness (LLT) and aqueous tear production after botulinum neurotoxin A (BoNT) injection in patients with benign essential blepharospasm (BEB) and hemifacial spasm (HFS). Eleven and six patients with BEB and HFS, respectively, who received BoNT injection were consecutively enrolled in this prospective study. The blepharospasm disability index (BSDI), blink pattern, dry eye symptoms, Schirmer test 1 findings, LLT, eyelid performance, and corneal integrity were evaluated before and after treatment...
May 30, 2018: Scientific Reports
Tina T Wong, Tin Aung, Ching Lin Ho
IMPORTANCE: Glaucoma treatment has often been associated with adverse side-effects from preservatives that are included in the used eye drops. BACKGROUND: To evaluate changes in the ocular surface and the presence of prostaglandin-induced corneal disorders after being switched from latanoprost 0.005% to low preservative tafluprost 0.0015% ophthalmic solution. DESIGN: Single centre, prospective study. PARTICIPANTS: Patients with primary open-angle glaucoma or ocular hypertension that had received treatment with once daily latanoprost 0...
May 26, 2018: Clinical & Experimental Ophthalmology
Won Ki Lee, Tomohiro Iida, Yuichiro Ogura, Shih-Jen Chen, Tien Yin Wong, Paul Mitchell, Gemmy Chui Ming Cheung, Zhongqi Zhang, Sérgio Leal, Tatsuro Ishibashi
Importance: Polypoidal choroidal vasculopathy (PCV) is common in Asian populations, but an optimal treatment approach remains to be confirmed. Objective: To evaluate intravitreal aflibercept injection (IAI) in participants with PCV and compare IAI monotherapy with IAI plus rescue photodynamic therapy (PDT). Design, Setting, and Participants: This 96-week, double-masked, sham-controlled phase 3b/4 randomized clinical trial was conducted at multiple centers in Australia, Germany, Hong Kong, Hungary, Japan, Singapore, South Korea, and Taiwan from May 2014 to August 2016, and included adults 50 years or older with symptomatic macular PCV and a best-corrected visual acuity of 73 to 24 Early Treatment Diabetic Retinopathy Study letters (20/40-20/320 Snellen equivalent)...
May 2, 2018: JAMA Ophthalmology
B Huang, P Li, Q X Meng, L He, X H Gao, J H Xie
Objective: To investigate the feasibility and effect of endoscopic-assisted posterior nasal neurotomy on patients with moderate-severe persistent allergic rhinitis (AR). Method: Endoscopic-assisted posterior nasal neurotomy were operated on 32 moderate-severe persistent AR patients who were insensitive to drugs and desensitization treatment,and curative effect were evaluated by scoring according to the diagnosis and curative effect evaluation standard of AR. Result: Follow-up evaluations were perfected after one year...
October 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Roger Lee Mendoza
AIM: We review clinical evidence of therapeutic efficacy and effectiveness of omega-3 fatty acids (omega-3s) in keratoconjunctivitis sicca, colloquially known as dry eye disease. In doing so, we identify relevant literature to address the following questions: 1) What definitive guidance can clinical evidence offer eye physicians and their patients? 2) What aspects of omega-3 supplementation lack definitive evidence, and how might economic assessments help? METHODS: A targeted and systematic search strategy based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) was designed in this study for refereed clinical trials of omega-3s in dry eye treatment...
May 21, 2018: Journal of Medical Economics
Hui Lin, Ying Liu, Siva P Kambhampati, Chih-Chien Hsu, Rangaramanujam M Kannan, Samuel C Yiu
PURPOSE: To investigate the efficacy of a single subconjunctival injection of dendrimer-dexamethasone to treat dry eye in a rabbit model of induced autoimmune dacryoadenitis (AID). METHOD: Dendrimer biodistribution after subconjuntival injection in AID animals was evaluated using Cy5-labelled dendrimer (D-Cy5) and confocal microscopy. Diseased animals were treated with free dexamethasone (Free-Dex), dendrimer-dexamethasone (D-Dex), or saline via a single subconjunctival injection...
May 16, 2018: Ocular Surface
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