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https://www.readbyqxmd.com/read/28549901/degradation-of-proteoglycan-4-lubricin-by-cathepsin-s-potential-mechanism-for-diminished-ocular-surface-lubrication-in-sj%C3%A3-gren-s-syndrome
#1
Suresh C Regmi, Michael L Samsom, Miriam Heynen, Gregory D Jay, Benjamin D Sullivan, Sruthi Srinivasan, Barbara Caffery, Lyndon Jones, Tannin A Schmidt
Sjögren's syndrome (SS) is an autoimmune disease affecting the lacrimal and salivary glands with hallmark clinical symptoms of dry eye and dry mouth. Recently, markedly increased cathepsin S (CTSS) activity has been observed in the tears of SS patients. Proteoglycan 4 (PRG4), also known as lubricin, is an effective boundary lubricant that is naturally present on the ocular surface. While PRG4 is susceptible to proteolytic digestion, the potential effect of CTSS on PRG4 remains unknown. The objective of this study was to assess the ability of CTSS to enzymatically degrade purified PRG4, and PRG4 naturally present in human tears, and alter ocular surface boundary lubricating properties...
May 23, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28542084/effects-of-diquafosol-ophthalmic-solution-on-quality-of-life-in-dry-eye-assessed-using-the-dry-eye-related-quality-of-life-score-questionnaire-effectiveness-in-patients-while-reading-and-using-visual-display-terminals
#2
Tsugiaki Utsunomiya, Atsushi Kawahara, Kazuomi Hanada, Akitoshi Yoshida
PURPOSE: Diquafosol ophthalmic solution improves objective findings in the ocular surface and subjective symptoms in patients with dry eye. The Dry Eye-Related Quality-of-Life Score (DEQS) questionnaire was developed to assess dry eye symptoms and their effects on quality of life. However, because little research using the DEQS has been reported, we evaluated the effects of diquafosol ophthalmic solution on ocular surface findings and quality of life using the DEQS in patients with dry eye...
May 23, 2017: Cornea
https://www.readbyqxmd.com/read/28537471/characteristics-of-labial-gland-mesenchymal-stem-cells-of-healthy-individuals-and-patients-with-sj%C3%A3-gren-syndrome-a-preliminary-study
#3
Shiqin Wang, Hong Hua, Yixiang Wang
Sjögren's Syndrome (SS) is a systemic autoimmune disease characterized by focal lymphocytic infiltration into exocrine organs such as salivary and lacrimal glands, resulting in dry mouth and eyes, and other systemic injuries. The mesenchymal stem cells (MSCs) in the salivary glands of healthy individuals and patients with SS have not been extensively studied. The aim of this study was to eluciadate the characteristics of MSCs from the labial glands of healthy controls and of those from patients with SS in order to elucidate the related pathogenesis and uncover potential avenues for novel clinical interventions...
May 24, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28533678/effect-of-thermal-pulsation-treatment-on-tear-film-parameters-in-dry-eye-disease-patients
#4
Michelle J Kim, Sandra S Stinnett, Preeya K Gupta
PURPOSE: The goal of this study was to evaluate the effect of thermal pulsation treatment on tear film parameters, specifically osmolarity and matrix metalloproteinase-9 (MMP-9), in patients with meibomian gland dysfunction (MGD) and dry eye disease (DED). METHODS: A single-center review of 189 eyes that underwent thermal pulsation treatment was performed. Data were collected on pre and posttreatment osmolarity, MMP-9, tear break-up time (TBUT), and ocular surface disease index (OSDI) score...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28532687/the-role-of-systemic-and-topical-fatty-acids-for-dry-eye-treatment
#5
REVIEW
Stefano Barabino, Jutta Horwath-Winter, Elisabeth M Messmer, Maurizio Rolando, Pasquale Aragona, Shigeru Kinoshita
Dry eye is a prevalent condition and one of the main reasons for patients to seek ophthalmic medical care. A low systemic level of omega fatty acids is a risk factor for dry eye disease (DED). There are two groups of essential fatty acids (EFAs): the omega-6 (n-6) family and the omega-3 (n-3) family. Humans evolved on a diet in which the n-6:n-3 ratio was approximately 1:1, however the current Western diet tends to be deficient in n-3 EFAs and this ratio is typically much higher (approaching 17:1). The metabolism of EFAs generates four new families of local acting mediators: lipoxins, resolvins, protectins, and maresins...
May 19, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28525563/omics-biomarkers-in-ophthalmology
#6
Susette Lauwen, Eiko K de Jong, Dirk J Lefeber, Anneke I den Hollander
"Omics" refers to high-throughput analyses of genes, proteins, or metabolites in a biological system, and is increasingly used for ophthalmic research. These system-based approaches can unravel disease-related processes and are valuable for biomarker discovery. Furthermore, potential therapeutic targets can be identified based on omics results, and targeted follow-up experiments can be designed to gain molecular understanding of the disease and to test new therapies. Here, we review the application of omics techniques in eye diseases, focusing on age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal detachment (RD), myopia, glaucoma, Fuchs' corneal dystrophy (FCD), cataract, keratoconus, and dry eyes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28524885/ocular-surface-analysis-in-hematological-patients-before-and-after-allogeneic-hematopoietic-stem-cell-transplantation-implication-for-daily-clinical-practice
#7
G Giannaccare, F Bonifazi, M Sessa, E Dan, M Arpinati, M Fresina, G Bandini, M Cavo, P Versura, E C Campos
PurposeTo evaluate ocular surface parameters before and after hematopoietic stem cell transplantation (HSCT) and to correlate them with clinical and transplant variables.MethodsThis is a retrospective analysis of data from 93 patients affected by hematological malignancies undergoing HSCT. Values from Ocular Surface Disease Index, Schirmer test, Break-up Time, ocular surface staining, and Meibomian Gland Dysfunction score obtained before HSCT and 3-6 months after were retrieved from charts. Diagnosis and staging of dry eye (DE) disease was performed according to Dry Eye WorkShop criteria...
May 19, 2017: Eye
https://www.readbyqxmd.com/read/28524142/-effectiveness-of-epithelialization-therapy-after-surgical-treatment-of-pterygiu
#8
A V Petraevskiy, K S Trishkin, I A Gndoyan
Pterygium is widely distributed in regions with hot and dry climate. Frequent relapses of the disease are due to delayed epithelialization of postoperative corneal erosion, associated inflammation and formation of dry areas of the cornea. Effective stimulation of corneal epithelium regeneration in the postoperative period could reduce the frequency of relapses. AIM: to compare the effectiveness, safety and tolerability of different keratoprotectors in patients after surgical treatment of pterygium...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28505677/-influence-of-aging-on-severity-and-anti-inflammatory-treatment-of-experimental-dry-eye-disease
#9
Philipp Steven, Tobias Braun, Sonja Krösser, Uta Gehlsen
Purpose Aging is an important factor in dry-eye disease that has not been studied in the context of therapeutic measures. Aging-associated modifications of the ocular immune system implicate that anti-inflammatory therapies may act differently among younger individuals in terms of onset and effect of different substances. The goal of this study was to determine differences in clinical phenotype and topical anti-inflammatory therapy using a desiccating stress mouse model. Methods An experimental dry-eye disease (desiccating stress model) was induced in 12-week and 12-month-old female BALB/c mice...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28503063/severe-symptoms-of-short-tear-break-up-time-dry-eye-are-associated-with-accommodative-microfluctuations
#10
Minako Kaido, Motoko Kawashima, Reiko Ishida, Kazuo Tsubota
AIM: Validating the hypothesis that accommodative microfluctuations (AMFs) may be associated with severe symptoms in short tear break-up time (BUT) dry eye (DE). METHODS: This study included 12 subjects with short BUT DE (age: 49.6±18.3 years). Diagnoses were performed based on the presence of DE symptoms, BUT ≤5 s, Schirmer score >5 mm, and negative keratoconjunctival epithelial damage. Tear evaluation, AMF, and functional visual acuity (VA) examinations were conducted before and after DE treatment...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28499370/is-hydroxychloroquine-effective-in-treating-primary-sjogren-s-syndrome-a-systematic-review-and-meta-analysis
#11
Shi-Qin Wang, Li-Wei Zhang, Pan Wei, Hong Hua
BACKGROUND: To systematically review and assess the efficacy and safety of hydroxychloroquine (HCQ) for treating primary Sjogren's syndrome (pSS). METHODS: Five electronic databases (Pubmed, EMBASE, Web of science, Ovid, Cochrane Library) were searched for randomized controlled trials and retrospective or prospective studies published in English that reported the effect of HCQ on pSS. The subjective symptoms (sicca symptoms, fatigue and pain) and the objective indexes (erythrocyte sedimentation rate and Schirmer test) were assessed as main outcome measures...
May 12, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28496300/prospective-evaluation-of-intense-pulsed-light-and-meibomian-gland-expression-efficacy-on-relieving-signs-and-symptoms-of-dry-eye-disease-due-to-meibomian-gland-dysfunction
#12
Steven J Dell, Ronald N Gaster, Sheila C Barbarino, Derek N Cunningham
PURPOSE: The aim of this study was to estimate the efficacy of intense pulsed light (IPL), followed by meibomian gland expression (MGX), for reducing the number and severity of signs and symptoms of dry eye disease (DED) secondary to meibomian gland dysfunction (MGD). PATIENTS AND METHODS: In a prospective study conducted in two sites, 40 subjects (80 eyes) with moderate to severe MGD were enrolled. Major inclusion criteria consisted of at least two of the following measures being compatible with DED in both eyes: tear breakup time (TBUT), meibomian gland score (MGS), corneal fluorescein staining (CFS), Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, and tear film osmolarity (TFO)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28481835/patients-perceived-treatment-effectiveness-in-dry-eye-disease
#13
Ahmad Kheirkhah, Alja Crnej, Ai Ren, Andrew Mullins, Vannarut Satitpitakul, Pedram Hamrah, Debra Schaumberg, Reza Dana
PURPOSE: Patients' perceptions of the effectiveness of a treatment, or perceived treatment effectiveness (PTE), play an important role in medicine. This study aimed to evaluate patients' PTE in dry eye disease (DED) and investigate factors contributing to these patients' perceptions. METHODS: This cross-sectional study included 66 patients with DED. At enrollment, all patients had comprehensive ophthalmic assessment. In addition, to evaluate the patient's PTE, they were asked to use a 10-point scale ranging from "strongly disagree (score 1)" to "strongly agree (score 10)" to score their views on whether their DED treatments had been effective...
May 3, 2017: Cornea
https://www.readbyqxmd.com/read/28476437/sjogren-s-syndrome-from-the-perspective-of-ophthalmology
#14
Eric Kuklinski, Penny A Asbell
Sjogren's syndrome (SS) is an autoimmune disease affecting the lacrimal glands resulting in dry eye disease (DED). Ophthalmologists may be the first line of detection of Sjogren's syndrome given the frequency of DED in SS and that dry eye is often the presenting symptom. Numerous symptom questionnaires and tests have been developed to help diagnose DED, but as of yet, there is no "gold standard." Minimally invasive objective metrics are needed for a reliable diagnosis of DED. Currently there is no single test to diagnose SS-associated DED...
May 2, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28476050/influence-of-pilocarpine-and-timolol-on-human-meibomian-gland-epithelial-cells
#15
Yi Zhang, Wendy R Kam, Yang Liu, Xiaomin Chen, David A Sullivan
PURPOSE: Investigators have discovered that topical antiglaucoma drugs may induce meibomian gland dysfunction. This response may contribute to the dry eye disease commonly found in patients with glaucoma taking such medications. We hypothesize that drug action involves a direct effect on human meibomian gland epithelial cells (HMGECs). To test this hypothesis, we examined the influence of the antiglaucoma drugs, pilocarpine and timolol, on the morphology, survival, proliferation, and differentiation of HMGECs...
June 2017: Cornea
https://www.readbyqxmd.com/read/28475698/the-growing-need-for-validated-biomarkers-and-endpoints-for-dry-eye-clinical-research
#16
Neeta S Roy, Yi Wei, Eric Kuklinski, Penny A Asbell
Purpose: Biomarkers with minimally invasive and reproducible objective metrics provide the key to future paradigm shifts in understanding of the underlying causes of dry eye disease (DED) and approaches to treatment of DED. We review biomarkers and their validity in providing objective metrics for DED clinical research and patient care. Methods: The English-language literature in PubMed primarily over the last decade was surveyed for studies related to identification of biomarkers of DED: (1) inflammation, (2) point-of-care, (3) ocular imaging, and (4) genetics...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28468509/effect-of-trospium-chloride-therapy-on-intraocular-pressure-and-tear-secretion-in-overactive-bladder-patients
#17
Ali Riza Turkoglu, Neslihan Parmak Yener, Soner Coban, Muhammet Guzelsoy, Ali Emul, Murat Demirbas, Hakan Demirci
PURPOSE: To investigate the effect of trospium chloride, which has an anticholinergic effect, used in overactive bladder (OAB) treatment on the intraocular pressure (IOP) and tear secretion after 12 weeks of treatment. MATERIALS AND METHODS: This prospective study was performed at a single center between October 2014 and January 2016. A detailed history was obtained from the female OAB patients at the eye outpatient department. After checking the exclusion criteria, oral trospium chloride 30 mg bd was started...
May 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28458508/meibomian-gland-dysfunction-patients-with-novel-sj%C3%A3-gren-s-syndrome-biomarkers-benefit-significantly-from-a-single-vectored-thermal-pulsation-procedure-a-retrospective-analysis
#18
Alice T Epitropoulos, Krysta Goslin, Raman Bedi, Caroline A Blackie
PURPOSE: To measure the effects from a single vectored thermal pulsation treatment of the meibomian glands on dry eye signs and symptoms in patients who tested positively versus negatively for novel Sjögren's syndrome (SS) biomarkers. METHODS: The retrospective study included the deidentified data of 102 eyes of 59 patients with dry eye and meibomian gland dysfunction (MGD), who were also tested for novel biomarkers for SS and underwent a single 12-minute LipiFlow thermal pulsation procedure...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28448732/cytomegalovirus-anterior-uveitis-following-topical-cyclosporine-a
#19
Jay Siak, Soon-Phaik Chee
Cytomegalovirus (CMV) anterior uveitis and endotheliitis occurs among immunocompetent individuals and may manifest as Posner-Schlossman syndrome or Fuchs uveitis syndrome. The condition may first present following ophthalmic surgery, the use of a fluocinolone-sustained steroid drug delivery implant, or the use of topical prostaglandin analogues for the treatment of glaucoma. We report the first case of a non-human immunodeficiency virus-infected individual who presented with CMV anterior uveitis after the use of topical cyclosporine A 0...
April 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28448672/correlation-between-the-inflammatory-marker-hla-dr-and-signs-and-symptoms-in-moderate-to-severe-dry-eye-disease
#20
Françoise Brignole-Baudouin, Luisa Riancho, Dahlia Ismail, Maëva Deniaud, Mourad Amrane, Christophe Baudouin
Purpose: To investigate correlations of the inflammatory HLA-DR marker with clinical signs and symptoms commonly used to assess dry eye disease (DED) severity. Methods: Baseline data were collected from three clinical studies conducted on moderate to severe DED patients. Characteristics of DED were analyzed and correlations were performed in 311 patients. Data were analyzed after treatment with 1 mg/mL cyclosporine (CsA) and vehicle. We quantified HLA-DR by flow cytometry in impression cytology specimens...
April 1, 2017: Investigative Ophthalmology & Visual Science
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