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https://www.readbyqxmd.com/read/29022291/comparison-of-contact-lens-corrected-quality-of-vision-and-life-of-keratoconus-and-myopic-patients
#1
Sunghoon Lee, Gangwook Jung, Hyung Keun Lee
PURPOSE: To compare and analyze changes in vision quality, subjective symptoms, and psycho-social satisfaction in keratoconus and myopic patients following the wearing of contact lenses. METHODS: This study enrolled 25 keratoconus and 25 myopic patients with corrected vision over 0.8 according to the Snellen chart due to treatment with contact lenses. Patients were surveyed prior to the wearing of contact lenses, and again after three months of contact lens usage with a questionnaire about quality of vision and life...
August 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28993732/purinergic-signalling-therapeutic-developments
#2
REVIEW
Geoffrey Burnstock
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990's when receptor subtypes for purines and pyrimidines were cloned and characterised, which includes four subtypes of the P1 (adenosine) receptor, seven subtypes of P2X ion channel receptors and 8 subtypes of the P2Y G protein-coupled receptor. Early studies were largely concerned with the physiology, pharmacology and biochemistry of purinergic signalling...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28991514/dacryocystectomy-indications-and-results-at-tertiary-eye-hospital-in-central-saudi-arabia
#3
Alicia Galindo-Ferreiro, Mohammed Dufaileej, Alberto Galvez-Ruiz, Rajiv Khandekar, Silvana A Schellini
PURPOSE: To report indications and success rates of dacryocystectomy (DCT) in a tertiary hospital. METHODS: A retrospective chart review was performed of all patients who underwent DCT at the King Khaled Eye Specialist Hospital, Saudi Arabia, from 2008 to 2015. Data included patient demographics, symptoms before and after surgery, and complications. Univariate analysis using parametric and non-parametric methods was performed. RESULTS: Forty-seven DCT surgeries were performed over the study period...
October 9, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28987229/controversies-in-oral-and-maxillofacial-oncology
#4
REVIEW
Jacob G Yetzer
Imaging studies are essential components of tumor diagnosis, staging, assessing tumor response to neoadjuvant and adjuvant therapies, and postoperative surveillance on completion of definitive treatment. Treatment of early stage clinically node negative oral cavity squamous cell carcinoma is controversial. Approximately 3% of all head and neck tumors arise within the parotid gland and most often within the superficial lobe, lateral to the facial nerve; about 80% are benign and most are pleomorphic adenoma. In patients with dry eyes failing multiple other treatment modalities and facing ongoing pain and loss of vision, microvascular transplant of the submandibular gland is a viable option...
November 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28983894/consecutive-case-series-of-244-age-related-macular-degeneration-patients-undergoing-implantation-with-an-extended-macular-vision-iol
#5
Muhammad A Qureshi, Scott J Robbie, Fritz H Hengerer, Gerd U Auffarth, Ina Conrad-Hengerer, Pablo Artal
PURPOSE: To determine safety and visual outcomes in eyes with age-related macular degeneration (AMD) implanted with a novel intraocular lens (IOL) that delivers an optimized retinal image to all macular areas within 10 degrees of retinal eccentricity. METHODS: This was a consecutive case series of 244 eyes with dry/stable wet AMD and logMAR visual acuity ≥0.3 implanted with iolAMD Eyemax monoTM (London Eye Hospital Pharma), a single-piece, injectable, hydrophobic acrylic IOL sited in the capsular bag...
October 5, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28972684/the-effects-of-topical-aqueous-sirolimus-on-tear-production-in-normal-dogs-and-dogs-with-refractory-dry-eye
#6
Ronald Spatola, Brad Nadelstein, Andrew Berdoulay, Robert V English
PURPOSE: To evaluate the effect of twice daily aqueous 0.02% sirolimus drops on tear production in normal dogs and dogs with refractory keratoconjunctivitis sicca (KCS). METHODS: Two groups of dogs were studied. Ten normal dogs with no signs of ocular disease were administered topical 0.02% sirolimus ophthalmic solution in right eye, and a vehicle control in the left eye twice daily for 4 weeks. Complete ophthalmic examinations, including Schirmer tear test were performed weekly...
October 3, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28969614/public-awareness-of-common-eye-diseases-in-jordan
#7
Mera F Haddad, May M Bakkar, Nour Abdo
BACKGROUND: Cataract, glaucoma, diabetic retinopathy and dry eye disease are common with high prevalence in Jordan. This study aims to assess the awareness of these ocular diseases among Jordanian population. METHOD: A self-designed questionnaire was developed in Arabic and used to interview people in different provinces of Jordan. Socio-demographic data e.g. age, gender and level of education was reported. Public awareness of four ocular diseases; cataract, glaucoma, diabetic retinopathy (DR) and dry eye disease (DED) was assessed...
October 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28967083/author-s-reply-to-concerns-over-efficacy-and-safety-of-0-1-cyclosporine-a-cationic-emulsion-in-the-treatment-of-severe-dry-eye-disease
#8
Andrea Leonardi, Gysbert Van Setten, Mourad Amrane, Dahlia Ismail, Jean-Sebastien Garrigue, Francisco C Figueiredo, Christophe Baudouin
No abstract text is available yet for this article.
September 28, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28967079/concerns-over-efficacy-and-safety-of-0-1-cyclosporine-a-cationic-emulsion-in-the-treatment-of-severe-dry-eye-disease
#9
Louis Clearkin
No abstract text is available yet for this article.
September 28, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28966960/seeking-optimal-management-for-radioactive-iodine-therapy-induced-adverse-effects
#10
REVIEW
Andreas Charalambous
Radioactive iodine therapy (RAIT) is one of the important treatment modalities in the management of differentiated thyroid cancer (DTC). RAIT with iodine-131 has long been used in the management of DTC for the ablation of residual thyroid or treatment of its metastases. Despite being reasonably safe, radioiodine therapy is not always without side effects. Even relatively low administered activities of RAIT used for remnant ablation have been associated with the more clinically significant side effects of sialadenitis, xerostomia, salivary gland pain and swelling, dry eyes, excessive tearing, or alterations in taste in as many as 25% of patients...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28961167/efficacy-of-a-fatty-acids-dietary-supplement-in-a-polyethylene-glycol-induced-mouse-model-of-retinal-degeneration
#11
Maurizio Cammalleri, Massimo Dal Monte, Filippo Locri, Emma Lardner, Anders Kvanta, Dario Rusciano, Helder André, Paola Bagnoli
Current knowledge of the benefits of nutrition supplements for eye pathologies is based largely on the use of appropriate animal models, together with defined dietary supplementation. Here, C57BL6 mice were subretinally injected with polyethylene glycol (PEG)-400, an established model of retinal degeneration with a dry age-related macular degeneration (AMD)-like phenotype, an eye pathology that lacks treatment. In response to PEG-400, markers of the complement system, angiogenesis, inflammation, gliosis, and macrophage infiltration were upregulated in both retinas and retinal pigment epithelium (RPE)/choroids, whereas dietary supplementation with a mixture based on fatty acids counteracted their upregulation...
September 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28956698/relevance-of-lipid-based-products-in-the-management-of-dry-eye-disease
#12
Jean-Sébastien Garrigue, Mourad Amrane, Marie-Odile Faure, Juha M Holopainen, Louis Tong
Components of the ocular surface synergistically contribute to maintaining and protecting a smooth refractive layer to facilitate the optimal transmission of light. At the air-water interface, the tear film lipid layer (TFLL), a mixture of lipids and proteins, plays a key role in tear surface tension and is important for the physiological hydration of the ocular surface and for ocular homeostasis. Alterations in tear fluid rheology, differences in lipid composition, or downregulation of specific tear proteins are found in most types of ocular surface disease, including dry eye disease (DED)...
September 28, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28956287/use-of-the-controlled-adverse-environment-cae-in-clinical-research-a-review
#13
REVIEW
George W Ousler, David Rimmer, Lisa M Smith, Mark B Abelson
The many internal and external factors that contribute to the pathophysiology of dry eye disease (DED) create a difficult milieu for its study and complicate its clinical diagnosis and treatment. The controlled adverse environment (CAE(®)) model has been developed to minimize the variability that arises from exogenous factors and to exacerbate the signs and symptoms of DED by stressing the ocular surface in a safe, standardized, controlled, and reproducible manner. By integrating sensitive, specific, and clinically relevant endpoints, the CAE has proven to be a unique and adaptable model for both identifying study-specific patient populations with modifiable signs and symptoms, and for tailoring the evaluation of interventions in clinical research studies...
September 27, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28953672/comparison-of-the-efficacy-between-topical-diquafosol-and-artificial-tears-in-the-treatment-of-dry-eye-following-cataract-surgery-a-meta-analysis-of-randomized-controlled-trials
#14
REVIEW
Xinyu Zhao, Song Xia, Youxin Chen
BACKGROUND: The prevalence of dry eye following cataract surgery was reported as high as 55.7%, this acute and iatrogenic disorder urgently required appropriate clinical management. The purpose of this study is to compare the efficacy of diquafosol sodium ophthalmic solution (DQS) and conventional artificial tears (AT) for the treatment of dry eye following cataract surgery. METHODS: The PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched from their earliest entries through June 2017 to obtain the studies, which evaluated the efficacy of DQS for patients with dry eye after cataract surgery...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28941123/renal-involvement-in-primary-sj%C3%A3-gren-s-syndrome-a-retrospective-study-of-103-biopsy-proven-cases-from-a-single-center-in-china
#15
Hua-Xia Yang, Jing Wang, Yu-Bing Wen, Yun-Yun Fei, Meng-Di Jiang, Meng-Yu Zhou, Wen Zhang, Hang Li, Xue-Mei Li, Feng-Chun Zhang, Xue-Wang Li, Xuan Zhang, Li-Meng Chen
AIM: To retrospectively investigate the features of renal involvements in patients with primary Sjögren's syndrome (pSS) with biopsy results. METHODS: A total of 2096 pSS inpatients at Peking Union Medical College Hospital in China from 2005 to 2015 were identified. Patients with biopsy-proven renal involvement (SS-renal) and matched controls (SS-only) were recruited. The clinical and pathologic features as well as treatments and outcomes were systematically analyzed...
September 21, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28933582/dynamic-sensitivity-of-corneal-trpm8-receptors-to-menthol-instillation-in-dry-eye-versus-normal-subjects
#16
Peter Corcoran, David A Hollander, George W Ousler, Endri Angjeli, David Rimmer, Keith Lane, Mark B Abelson
PURPOSE: To assess the sensitivity of corneal cold receptors to a known transient receptor potential melastatin 8 (TRPM8) agonist, menthol, in dry eye and normals, and to determine whether factors such as disease duration or age affect responses. METHODS: Dry eye disease (DED) (N = 33) and normal (N = 15) subjects were randomly assigned to receive Rohto(®) Hydra (0.01% menthol) or Systane(®) Ultra treatments (OU) in a prospective, double-blind, crossover study...
September 21, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28930884/rate-of-macular-ganglion-cell-inner-plexiform-layer-thinning-in-glaucomatous-eyes-with-vascular-endothelial-growth-factor-inhibition
#17
Won June Lee, Young Kook Kim, Yong Woo Kim, Jin Wook Jeoung, Seok Hwan Kim, Jang Won Heo, Hyeong Gon Yu, Ki Ho Park
PURPOSE: To evaluate the rate of progressive macular ganglion cell-inner plexiform layer (GCIPL) thinning in patients with open-angle glaucoma (OAG) who had been treated with intravitreal anti-vascular endothelial growth factor (VEGF) injection for wet age-related macular degeneration (AMD). METHODS: This study was a retrospective modified case control study with fellow-eye comparison. We enrolled bilateral OAG patients who had been treated with repeated anti-VEGF injections for unilateral wet AMD and followed-up on for a minimum of 24 months by Cirrus high-definition optical coherence tomography (HD-OCT)...
September 19, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28926881/-emphasizing-the-diagnosis-and-treatment-of-diabetes-related-dry-eye
#18
J Yuan, Y Q Deng
Nowadays, diabetes is quickly emerging as one of the biggest health-related catastrophes over the world. Its impact on people's quality of life has been gradually taken seriously. In the past few years, the connection linking dry eye to diabetes has been substantially confirmed by a series of studies. However, many areas remain uncertain due to the complex and diverse pathogeneses of diabetes related dry eye syndrome. Furthermore, the slow progression of dry eye symptoms easily conceals its connection with diabetes, which brings great challenges to timely diagnosis and effective interventions...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28926880/-emphasis-on-standardization-and-refinement-in-the-diagnosis-and-treatment-of-dry-eye
#19
Z G Liu
Dry eye is the second most common ocular disease. In China, the incidence rate of dry eye has reached 21% to 30%, and dry eye patients have accounted for more than 30% of the total ophthalmology outpatients. Dry eye has become a common health problem that affects the working efficiency and life quality of Chinese people. Over the past decade, due to the rapid development of diagnostic equipments and new treatments for dry eye, dry eye has become one of the areas with greatest concerns in ophthalmology, and many eye institutions have set up their dry eye clinics...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28922378/relationships-of-orientation-discrimination-threshold-and-visual-acuity-with-macular-lesions-in-age-related-macular-degeneration
#20
Haojie Fu, Bin Zhang, Jianliang Tong, Harold Bedell, Hecheng Zhang, Yating Yang, Chaochao Nie, Yingdong Luo, Xiaoling Liu
PURPOSE: To measure visual acuity and metamorphopsia in patients with age-related macular degeneration (AMD) and to explore their relationship with macular lesions. METHODS: In this cross-sectional study, a total of 32 normal subjects (32 eyes) and 35 AMD patients (35 eyes) were recruited. They were categorized into 4 groups: normal, dry AMD, non-active wet AMD, and active wet AMD. Best-corrected visual acuity (BCVA) was measured using the Early Treatment Diabetic Retinopathy Study protocol...
2017: PloS One
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