Yuanting Yang, Qisheng Lin, Xuying Zhu, Xinghua Shao, Shu Li, Jialin Li, Jingkui Wu, Haijiao Jin, Chaojun Qi, Na Jiang, Kaiqi Zhang, Qin Wang, Leyi Gu, Zhaohui Ni
Sepsis-induced acute kidney injury (S-AKI) is the most common type of acute kidney injury (AKI), accompanied by elevated morbidity and mortality rates. This study investigated the mechanism by which lipid droplets (LDs) degraded via autophagy (lipophagy)required for RAB7 regulated ferroptosis in the pathogenesis of S-AKI. Here, we constructed the S-AKI model in vitro and in vivo to elucidate the potential relationship of lipophagy and ferroptosis, and we first confirmed that the activation of lipophagy promoted renal tubular epithelial cell ferroptosis and renal damage in S-AKI...
April 5, 2024: Free Radical Biology & Medicine