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https://www.readbyqxmd.com/read/29785258/intra-articular-biomaterials-assisted-delivery-to-treat-temporomandibular-joint-disorders
#1
Khandmaa Dashnyam, Jung-Hwan Lee, Nandin Mandakhbayar, Guang-Zhen Jin, Hae-Hyoung Lee, Hae-Won Kim
The temporomandibular joint disorder, also known as myofascial pain syndrome, is considered one of the prevalent chronic pain diseases caused by muscle inflammation and cartilage degradation in head and neck, and thus influences even biopsychosocial conditions in a lifetime. There are several current treatment methodologies relieving inflammation and preventing degradation of the joint complex. One of the promising non-surgical treatment methods is an intra-articular injection of drugs such as corticosteroids, analgesics, and anti-depressants...
January 2018: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/29774156/pilot-study-of-orphenadrine-as-a-novel-treatment-for-muscle-cramps-in-patients-with-liver-cirrhosis
#2
Sherief Abd-Elsalam, Ferial El-Kalla, Lobna A Ali, Samah Mosaad, Walaa Alkhalawany, Berihan Elemary, Rehab Badawi, Asmaa Elzeftawy, Amr Hanafy, Asem Elfert
Background and aims: Muscle cramps markedly affect the quality of life in cirrhotic patients with no available highly effective treatment. The aim of this study was to assess the safety and efficacy of orphenadrine in the treatment of muscle cramps in cirrhotic patients. Methods: The study enrolled 30 liver cirrhosis patients complaining of frequent muscle cramps (≥3 per week), who were randomized to receive either orphenadrine 100 mg or calcium carbonate 500 mg twice daily as a control for one month...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29767912/gender-differences-in-the-perception-of-quality-of-life-of-patients-with-colorectal-cancer
#3
Isadora Trinquinato, Rodrigo Marques da Silva, Sonia Betzabeth Ticona Benavente, Camila Cristine Antonietti, Ana Lúcia Siqueira Costa Calache
OBJECTIVES: To identify the gender differences in assessing quality of life of patients undergoing chemotherapy treatment for colorectal cancer. METHODS: This is a cross-sectional investigation conducted with 144 patients (72 men and 72 women) undergoing chemotherapy treatment in a southeastern Brazilian hospital. Data were gathered trough a sociodemographic and clinical information form and the Health-related Quality of Life instrument from the European Organization for Research and Treatment of Cancer...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29761479/antidepressants-for-insomnia-in-adults
#4
REVIEW
Hazel Everitt, David S Baldwin, Beth Stuart, Gosia Lipinska, Andrew Mayers, Andrea L Malizia, Christopher Cf Manson, Sue Wilson
BACKGROUND: Insomnia disorder is a subjective condition of unsatisfactory sleep (e.g. sleep onset, maintenance, early waking, impairment of daytime functioning). Insomnia disorder impairs quality of life and is associated with an increased risk of physical and mental health problems including anxiety, depression, drug and alcohol abuse, and increased health service use. hypnotic medications (e.g. benzodiazepines and 'Z' drugs) are licensed for sleep promotion, but can induce tolerance and dependence, although many people remain on long-term treatment...
May 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29752752/long-term-safety-and-efficacy-of-the-novel-%C3%AE-3-adrenoreceptor-agonist-vibegron-in-japanese-patients-with-overactive-bladder-a-phase-iii-prospective-study
#5
Masaki Yoshida, Hidehiro Kakizaki, Satoru Takahashi, Shinji Nagai, Takafumi Kurose
OBJECTIVES: To evaluate the long-term safety and efficacy of vibegron 50 mg and 100 mg, a novel β3 -adrenoreceptor agonist, in Japanese patients with overactive bladder. METHODS: This was a 1-year, multicenter, open-label, non-controlled study. After a 1-week observation phase, patients were treated with vibegron for 52 weeks. When the efficacy was insufficient after an 8-week treatment with 50 mg, the dose was increased to 100 mg and maintained for an additional 44 weeks...
May 11, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29752180/-177-lu-psma-617-radionuclide-treatment-in-patients-with-metastatic-castration-resistant-prostate-cancer-lupsma-trial-a-single-centre-single-arm-phase-2-study
#6
Michael S Hofman, John Violet, Rodney J Hicks, Justin Ferdinandus, Sue Ping Thang, Tim Akhurst, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Declan G Murphy, Peter Eu, Price Jackson, Mark Scalzo, Scott G Williams, Shahneen Sandhu
BACKGROUND: Progressive metastatic castration-resistant prostate cancer is a highly lethal disorder and new effective therapeutic agents that improve patient outcomes are urgently needed. Lutetium-177 [177 Lu]-PSMA-617, a radiolabelled small molecule, binds with high affinity to prostate-specific membrane antigen (PSMA) enabling beta particle therapy targeted to metastatic castration-resistant prostate cancer. We aimed to investigate the safety, efficacy, and effect on quality of life of [177 Lu]-PSMA-617 in men with metastatic castration-resistant prostate cancer who progressed after standard treatments...
May 7, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29748448/health-related-quality-of-life-in-oropharyngeal-cancer-survivors-a-population-based-study
#7
Thomas Guenzel, U Walliczek-Dworschak, A Teymoortash, S Singer, M Eichler, T Wilhelm, M Schimmer, A Franzen
OBJECTIVE: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments. SUBJECTS AND METHODS: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. RESULTS: A total of 263 survivors completed the questionnaires (28% responses). Forty-five of them had undergone surgery, 20 had received definitive radiotherapy or chemo-radiotherapy, 85 surgery plus adjuvant radiotherapy, and 111 surgery plus adjuvant chemo-radiotherapy...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29737501/safety-of-tamsulosin-a-systematic-review-of-randomized-trials-with-a-focus-on-women-and-children
#8
REVIEW
Steven A Kaplan, Bilal I Chughtai
INTRODUCTION: Although tamsulosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH), it has also been assessed in clinical studies for other conditions/symptoms and in other populations such as women and children. In this systematic review of randomized studies, the overall safety of tamsulosin was assessed, focusing on these understudied populations. METHODS: Literature searches were conducted using Embase, Medline, and PubMed (inception-December 2015)...
May 8, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29719417/pharmacotherapeutic-considerations-for-use-of-cannabinoids-to-relieve-pain-in-patients-with-malignant-diseases
#9
REVIEW
Marija Darkovska-Serafimovska, Tijana Serafimovska, Zorica Arsova-Sarafinovska, Sasho Stefanoski, Zlatko Keskovski, Trajan Balkanov
Purpose: The aim of this review was to assess the efficacy of cannabis preparations for relieving pain in patients with malignant diseases, through a systematic review of randomized controlled trials (RCTs), which were predominantly double-blind trials that compared cannabis preparation to a placebo. Methods: An electronic search of all literature published until June 2017 was made in MEDLINE/PubMed, Embase, The Cochrane Controlled Trials Register and specific web pages devoted to cannabis...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29709423/basic-and-clinical-aspects-of-antimuscarinic-agents-used-to-treat-overactive-bladder
#10
REVIEW
Shizuo Yamada, Yoshihiko Ito, Saori Nishijima, Katsumi Kadekawa, Kimio Sugaya
Antimuscarinic agents are now widely used as the pharmacological therapy for overactive bladder (OAB) because neuronal (parasympathetic nerve) and non-neuronal acetylcholine play a significant role for the bladder function. In this review, we will highlight basic and clinical aspects of eight antimuscarinic agents (oxybutynin, propiverine, tolterodine, solifenacin, darifenacin, trospium, imidafenacin, and fesoterodine) clinically used to treat urinary dysfunction in patients with OAB. The basic pharmacological characteristics of these eight antimuscarinic agents include muscarinic receptor subtype selectivity, functional bladder selectivity, and muscarinic receptor binding in the bladder and other tissues...
April 27, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29699858/efficacy-and-tolerability-of-mirabegron-compared-with-antimuscarinic-monotherapy-or-combination-therapies-for-overactive-bladder-a-systematic-review-and-network-meta-analysis
#11
Con Kelleher, Zalmai Hakimi, Richard Zur, Emad Siddiqui, Khaled Maman, Samuel Aballéa, Jameel Nazir, Chris Chapple
BACKGROUND: Mirabegron is an established treatment alternative to antimuscarinic therapy for patients with overactive bladder (OAB), as shown by efficacy and tolerability data from phase III trials. OBJECTIVE: To assess efficacy and tolerability of mirabegron 50mg versus antimuscarinic monotherapies and combination therapies. DESIGN, SETTING, AND PARTICIPANTS: Systematic literature review and network meta-analysis of randomised controlled trials (2000-2017) assessing eligible treatments for OAB...
April 23, 2018: European Urology
https://www.readbyqxmd.com/read/29697209/efficacy-and-safety-of-mirabegron-a-%C3%AE-3-adrenoceptor-agonist-in-patients-with-detrusor-hyperactivity-and-impaired-contractility
#12
Cheng-Ling Lee, Hann-Chorng Kuo
OBJECTIVE: We examined the efficacy and safety of mirabegron in elderly patients with urodynamic detrusor hyperactivity with impaired contractility (DHIC). METHODS: Patients diagnosed with DHIC received daily dose of mirabegron (25mg). Subjective symptom scores, uroflowmetry data, and adverse events (AEs) were recorded for all patients at baseline and after 1, 3, and 6 months treatment. Comparisons were made for each patient individually and between patients with detrusor overactivity (DO)...
April 26, 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29682268/polysonographical-evaluation-in-a-case-of-moderate-osas-treated-with-mandibular-advancement-device
#13
A Venditti, M Basili, F M Ragazzoni, A Barlattani, P Bollero
Background: The Obstructive Sleep Apnea Syndrome (OSAS) is a clinical picture characterized by partial or complete obstruction of the upper airway during sleep, associated with a reduction of oxygen saturation in the blood.The most common symptoms are: apnea sleep, snoring, headache, sleepiness, reduced concentration and memory, irritability, increased blood pressure and dry mouth. Materials and methods: It was examinated a not-smoker man of 54 years that suffers of roncophaty...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29670356/comparative-effectiveness-of-switching-paroxetine-formulation-for-treatment-of-major-depressive-disorder-an-open-label-multicenter-study
#14
Tempei Otsubo, Yoshinori Watanabe, Seiji Hongo, Mikichika Inoue, Kimiko Akimoto, Ken Murakami, Ryutaro Takahashi, Toshiaki Kikuchi
Aim: To assess the effectiveness and safety of switching the antidepressant formulation from immediate-release (IR) to controlled-release (CR) paroxetine in patients with major depressive disorder (MDD). Patients and methods: A total of 113 outpatients with MDD diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition, Text Revision, and treated with a stable dose of IR paroxetine for at least 6 months were enrolled. Patients were then switched to CR paroxetine for 8 weeks...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29661295/quality-of-life-in-thyroid-cancer-assessment-of-physician-perceptions
#15
Benjamin C James, Briseis Aschebrook-Kilfoy, Michael G White, Megan K Applewhite, Sharone P Kaplan, Peter Angelos, Edwin L Kaplan, Raymon H Grogan
BACKGROUND: Thyroid cancer is the fastest growing malignancy in the United States. Previous studies have shown a decrease in quality of life (QoL) after the treatment of thyroid cancer. To date, there have been no studies assessing physician perceptions regarding how a diagnosis of thyroid cancer affects QoL. Based on this and other findings from our study, we aim to assess physician perceptions on the effect of thyroid cancer on QoL. MATERIALS AND METHODS: Physicians were recruited from two national organizations comprised physicians focusing on thyroid cancer...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29619496/barriers-to-special-care-patients-with-mental-illness-receiving-oral-healthcare-a-cross-sectional-study-in-the-holy-city-of-makkah-saudi-arabia
#16
Mohsen K Aljabri, Ibrahim Z Gadibalban, Aboelezz M Kalboush, Hesham S Sadek, Hassan H Abed
To assess barriers to patients with mental illness receiving oral healthcare in Makkah city, Saudi Arabia. Methods: This was a 3-month cross-sectional study from the Department of Psychiatry at Al-Noor, Specialist Hospital in Makkah city, Saudi Arabia, between January 2017 and April 2017. A structured questionnaire with closed-ended questions was considered. A total of 161 psychiatric patients were recruited, made up of 81 male (50.3%) and 80 female (49.7%) participants. Simple descriptive statistics were used to define the characteristics of the study variables, through a form of counts and percentages...
April 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29614832/ixeris-dentata-extract-increases-salivary-secretion-through-the-regulation-of-endoplasmic-reticulum-stress-in-a-diabetes-induced-xerostomia-rat-model
#17
Kashi Raj Bhattarai, Hwa-Young Lee, Seung-Hyun Kim, Hyung-Ryong Kim, Han-Jung Chae
This study aimed to investigate the molecular mechanism of diabetes mellitus (DM)-induced dry mouth and an application of natural products from Ixeris dentata (IXD), a recently suggested regulator of amylase secretion in salivary cells. Vehicle-treated or diabetic rats were orally treated with either water or an IXD extract for 10 days to observe the effect on salivary flow. We found that the IXD extract increased aquaporin 5 (AQP5) and alpha-amylase protein expression in the submandibular gland along with salivary flow rate...
April 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29600400/do-patient-characteristics-predict-which-patients-with-overactive-bladder-benefit-from-a-higher-fesoterodine-dose
#18
Howard B Goldman, Matthias Oelke, Steven A Kaplan, Tekeya Kitta, David Russell, Martin Carlsson, Daniel Arumi, Erin Mangan, Fady Ntanios
INTRODUCTION AND HYPOTHESIS: We sought to determine whether baseline characteristics predict which overactive bladder (OAB) patients benefit from fesoterodine 8 mg versus 4 mg. METHODS: In double-blind, placebo-controlled, flexible-dose trials, baseline characteristics of OAB patients with ≥ 1 urgency urinary incontinence (UUI) episodes/24 h who escalated from fesoterodine 4 mg to 8 mg were evaluated. Possible dose-escalation predictors (age; sex; previous antimuscarinic use; UUI, micturitions, and urgency episodes/24 h; race; body mass index; time to dose escalation; OAB duration) were compared in escalators versus non-escalators...
March 29, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29579828/chronic-pain-treatment-with-cannabidiol-in-kidney-transplant-patients-in-uruguay
#19
L Cuñetti, L Manzo, R Peyraube, J Arnaiz, L Curi, S Orihuela
BACKGROUND: Chronic pain is a major therapeutic problem in kidney transplant patients owing to nephrotoxicity associated with nonsteroidal antiiflammatory drugs. Benefits in chronic pain treatment with cannabidiol (CBD) have been reported. This study assesses the effect, safety, and possible drug interactions in kidney transplant patients treated with CBD for chronic pain. METHODS: We assessed patients who asked to receive CBD for pain treatment. Doses were increased from 50 to 150 mg twice a day for 3 weeks...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29579339/mature-results-of-a-prospective-study-of-deintensified-chemoradiotherapy-for-low-risk-human-papillomavirus-associated-oropharyngeal-squamous-cell-carcinoma
#20
Bhishamjit S Chera, Robert J Amdur, Joel E Tepper, Xianming Tan, Jared Weiss, Juneko E Grilley-Olson, D Neil Hayes, Adam Zanation, Trevor G Hackman, Samip Patel, Nathan Sheets, Mark C Weissler, William M Mendenhall
BACKGROUND: The purpose of the current study was to determine quality of life and tumor control from a prospective phase 2 clinical trial evaluating deintensified chemoradiotherapy for favorable risk, human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma. METHODS: Patients with T0-T3, N0-N2c, M0, p16-positive disease and a minimal smoking history were treated with 60 grays of intensity-modulated radiotherapy with concurrent weekly intravenous cisplatin (30 mg/m2 )...
March 26, 2018: Cancer
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