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https://www.readbyqxmd.com/read/28421993/increased-expression-of-interferon-%C3%AE-in-minor-salivary-glands-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-and-its-synergic-effect-with-interferon-%C3%AE-on-salivary-gland-epithelial-cells
#1
You-Jung Ha, Yong Seok Choi, Eun Ha Kang, Jin-Haeng Chung, Seunghee Cha, Yeong Wook Song, Yun Jong Lee
OBJECTIVES: To investigate the expressions of interferon (IFN)-λs and their receptor, IL28RA, in minor salivary glands (MSG) of pSS patients and their effects on the salivary gland cells. METHODS: The expressions of IFN-λs and IL28RA were evaluated in MSG by immunohistochemistry in 15 patients with pSS and in 5 patients with non-SS sicca. Poly(I:C)-induced IL-28A and IL-29 expressions were determined in immortalized human salivary gland acinar (NS-SV-AC) and ductal (NS-SV-DC) cell lines...
April 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28420093/potential-role-of-free-fatty-acids-in-the-pathogenesis-of-periodontitis-and-primary-sj%C3%A3-gren-s-syndrome
#2
REVIEW
Yosuke Shikama, Yasusei Kudo, Naozumi Ishimaru, Makoto Funaki
Clinical studies have shown that metabolic disorders such as type 2 diabetes and dyslipidemia are associated with increased risk of oral-related diseases, such as periodontitis and Sjögren's syndrome. Although changes in the immune system are critical in both of these metabolic disorders and oral-related diseases, the mechanism underlying the interaction between these diseases remains largely unknown. Obesity and type 2 diabetes are known to be associated with higher concentrations of free fatty acids in blood...
April 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28416413/evaluation-of-the-physiotel%C3%A2-digital-m11-cardiovascular-telemetry-implant-in-socially-housed-cynomolgus-monkeys-up-to-16weeks-after-surgery
#3
Ninette K Andersen, Olivier Meyer, Alys Bradley, Nils Dragsted, Anders B Lassen, Ingrid Sjögren, Julie M Larsen, Warren Harvey, Rastislav Bator, Aileen Milne
INTRODUCTION: The novel PhysioTel™ Digital M11 telemetry implant was evaluated in socially housed monkeys with respect to both safety pharmacological cardiovascular (arterial blood pressure (BP), heart rate (HR) and electrocardiogram (ECG)) and toxicological (clinical pathology and histopathology) endpoints. METHODS: Telemetry and clinical pathology data were obtained repeatedly up to 16weeks after surgery in four female cynomolgus monkeys, followed by necropsy...
April 14, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28415674/primary-sj%C3%A3-gren-s-syndrome-with-diffuse-cystic-lung-changes-developed-systemic-lupus-erythematosus-a-case-report-and-literature-review
#4
Xiao Liu, Hao Li, Yunhong Yin, Dedong Ma, Yiqing Qu
Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease that can occur as a unique existence (primary Sjögren's syndrome) or merge with other systemic diseases like systemic lupus erythematosus (SLE), rheumatoid arthritis or systemic sclerosis (secondary Sjögren's syndrome). Data on the two diseases occurrence order are inadequate. Primary Sjögren's syndrome (pSS) may relatively uncommonly lead to diffuse cystic lung changes. We represent a female who was diagnosed pSS with diffuse cystic lung alterations developed SLE two years later...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414714/excess-atherosclerosis-in-systemic-lupus-erythematosus-a-matter-of-renal-involvement-case-control-study-of-281-sle-patients-and-281-individually-matched-population-controls
#5
Johanna T Gustafsson, Marie Herlitz Lindberg, Iva Gunnarsson, Susanne Pettersson, Kerstin Elvin, John Öhrvik, Anders Larsson, Kerstin Jensen-Urstad, Elisabet Svenungsson
BACKGROUND: Systemic lupus erythematosus (SLE), is a heterogeneous disease which predominantly affects young females (90%). SLE is associated with a shorter life expectancy than in the general population. Standardized mortality ratios (SMR) of 2.4 have been reported, which is comparable to diabetes. In modern societies cardiovascular disease (CVD) is the major cause of premature mortality. Accelerated atherosclerosis is generally assumed to be the underlying cause for SLE related CVD...
2017: PloS One
https://www.readbyqxmd.com/read/28397684/-body-dysmorphic-disorder
#6
Mustafa Bashir M Jawad, Magnus Sjögren
Body dysmorphic disorder is defined by a preoccupation of one or more non-existent or slight defects or flaws in the physical appearance. The prevalence is 1.7-2.4% in the general population with a higher incidence rate in women. The rate of suicidal ideation is as high as 80%, and up to 25% of the patients attempt to commit suicide. Comorbidities, such as obsessive compulsive disorder, depression, and anxiety, are frequent. These patients may seek cosmetic or dermatologic rather than psychological treatment...
February 6, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28390747/fcrl4-b-cells-in-salivary-glands-of-primary-sj%C3%A3-gren-s-syndrome-patients
#7
Erlin A Haacke, Hendrika Bootsma, Fred K L Spijkervet, Annie Visser, Arjan Vissink, Philip M Kluin, Frans G M Kroese
Fc receptor-like protein 4 (FcRL4) is normally expressed on a small subset of mucosa-associated B-cells, as well as on mucosa-associated lymphoid tissue (MALT) lymphoma B-cells. Primary Sjögren's syndrome (pSS) patients have an increased risk of developing MALT lymphomas, preferentially in the parotid glands. For this reason we studied here by immunohistochemistry and mRNA analysis whether FcRL4 expressing B-cells are present in salivary gland tissue (labial and parotid) of pSS patients (n = 54) and non-pSS sicca patients (n = 16) and whether parotid gland MALT lymphomas in pSS patients (n = 49) also express this receptor...
April 5, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28386159/severe-reactive-ischemic-posterior-segment-inflammation-in-acanthamoeba-keratitis-case-report-of-a%C3%A2-patient-with-sj%C3%A3-gren-s-syndrome
#8
Christoph Palme, Bernhard Steger, Gertrud Haas, Barbara Teuchner, Nikolaos E Bechrakis
PURPOSE: We report on a case of Acanthamoeba keratitis (AK)-related reactive ischemic posterior segment inflammation following intraocular surgery in a patient with primary Sjögren's syndrome (PSS). CASE REPORT: A 48-year-old female patient with severe protracted AK underwent uneventful cataract surgery upon development of a corneal scar. Four weeks postoperatively, she experienced a rapid loss of vision to no light perception. Central retinal artery occlusion and ischemic optic neuropathy could be excluded, and a diagnosis of PSS was made...
2017: Spektrum der Augenheilkunde: Zeitschrift der Österreichischen Ophthalmologischen Gesellschaft, ÖOG
https://www.readbyqxmd.com/read/28379880/immunoresponsive-autonomic-neuropathy-in-sj%C3%A3-gren-syndrome-case-series-and-literature-review
#9
Brent P Goodman
BACKGROUND: Sjögren syndrome (SS) is one of the most common autoimmune disorders that classically affects exocrine glands, resulting in keratoconjunctivitis sicca and xerostomia, and frequently is associated with other systemic symptoms. SS appears to have a particular predilection for involving the autonomic nervous system. STUDY QUESTION: Does immunotherapy improve signs and symptoms of autonomic nervous system impairment in SS? STUDY DESIGN: This is a retrospective review of patients seen in the autonomic clinic at our institution who underwent an evaluation for a suspected autonomic disorder that ultimately was attributed to SS...
March 31, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28375792/safety-and-efficacy-of-cortisol-phosphate-in-hyaluronic-acid-vehicle-in-the-treatment-of-dry-eye-in-sjogren-syndrome
#10
Maurizio Rolando, Aldo Vagge
PURPOSE: Evaluation of 0.3% cortisol phosphate eye drops in hyaluronic acid vehicle in the treatment of dry eye in Sjogren Syndrome. METHODS: This prospective, single-center, masked (single blind), randomized controlled study included 40 female patients divided into 2 groups, group 1 treated with Idracemi, 0.3% cortisol phosphate eye drops twice a day, and group 2 treated with Cortivis, 0.3% cortisol phosphate in hyaluronic acid vehicle, with the same posology. Screening (day -7), randomization (day 0), follow-up (day 7), and termination (day 28) visits were conducted...
April 4, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28375790/the-effect-of-immunologically-safe-plasma-rich-in-growth-factor-eye-drops-in-patients-with-sj%C3%A3-gren-syndrome
#11
Ronald Mauricio Sanchez-Avila, Jesus Merayo-Lloves, Ana Cristina Riestra, Eduardo Anitua, Francisco Muruzabal, Gorka Orive, Luis Fernández-Vega
PURPOSE: The objective was to provide preliminary information about the efficacy and safety of immunologically safe plasma rich in growth factor (immunosafe PRGF) eye drops in the treatment of moderate to severe dry eye in patients with primary and secondary Sjögren's syndrome (SS) and to analyze the influence of several variables on treatment outcomes. METHODS: This retrospective study included patients with SS. All patients were treated with previously immunosafe PRGF eye drops to reduce the immunologic component contents...
April 4, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28371120/condom-use-among-swedes-while-traveling-internationally-a-qualitative-descriptive-study
#12
Eva Lejelind, Ragnar Westerling, Kerstin Sjögren Fugl-Meyer, Kjerstin Larsson
This study explores factors influencing condom use among Swedish women and men who visited a sexual health clinic after unprotected sex during international travel. Semi-structured interviews were conducted with 25 women and 25 men. The data were analyzed using conventional content analysis. The informants' narratives were categorized as strategies and barriers. Strategies found were: risk assessment, testing, and treatment for sexually transmitted infections. The barriers were characterized as technical and personal or emotional...
March 30, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/28367361/transoral-laser-microsurgery-in-early-glottic-lesions
#13
REVIEW
E V Sjögren
PURPOSE OF REVIEW: To give an overview of the evolvement of transoral laser microsurgery (TLM) in the treatment of early glottic carcinoma and highlight the contribution of recent literature. RECENT FINDINGS: The indications and limits of TLM have been well specified. Effects on swallowing have been well documented. Introduction of narrow-band imaging (NBI) and diffusion-weighted magnetic resonance has been shown of additional value for outcome. The first reports on transoral robotic surgery show that it may be of added value in the future...
2017: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/28367079/reviewing-primary-sj%C3%A3-gren-s-syndrome-beyond-the-dryness-from-pathophysiology-to-diagnosis-and-treatment
#14
REVIEW
Tim Both, Virgil A S H Dalm, P Martin van Hagen, Paul L A van Daele
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, characterized by lymphocytic infiltration of the secretory glands. This process leads to sicca syndrome, which is the combination of dryness of the eyes, oral cavity, pharynx, larynx and/or vagina. Extraglandular manifestations may also be prevalent in patients with pSS, including cutaneous, musculoskeletal, pulmonary, renal, hematological and neurological involvement. The pathogenesis of pSS is currently not well understood, but increased activation of B cells followed by immune complex formation and autoantibody production are thought to play important roles...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28361884/at-rvd1-promotes-resolution-of-inflammation-in-nod-shiltj-mice
#15
Ching-Shuen Wang, Christina L Maruyama, Justin T Easley, Bryan G Trump, Olga J Baker
Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Treatments for hyposalivation are limited to the use of saliva substitutes and medications that provide only temporary relief. In light of the high degree of need and the limitations of current therapies, development of alternative treatments to restore functioning is essential. Resolvins (Rv), which are highly potent lipid mediators, offer a viable alternative for better treating inflammatory diseases such as SS...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28359271/the-2016-classification-criteria-for-primary-sjogren-s-syndrome-what-s-new
#16
Franco Franceschini, Ilaria Cavazzana, Laura Andreoli, Angela Tincani
New 2016 ACR/EULAR classification criteria for primary Sjogren's syndrome (SS) have been developed and endorsed by the ACR. The newly proposed criteria include simple-to-perform items.Two important points of the new criteria should be considered. Firstly, they indicate that either salivary gland biopsy or anti-Ro must be positive in order to corroborate the inflammatory and autoimmune nature of the disease. Secondly, the criteria recognize the systemic nature of SS, namely that patients without salivary or ocular glandular symptoms, but with extraglandular manifestations and B cell activation markers were also included in the SS classification...
March 31, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28352491/acquired-factor-viii-deficiency-two-case-reports-and-a-review-of-literature
#17
Lan Mo, George C Bao
BACKGROUND: Acquired factor VIII (FVIII) deficiency, or acquired hemophilia A (AHA), is a rare autoimmune disorder involving antibody-mediated depletion of coagulation FVIII, leading to severe, life-threatening bleeding. The condition is often associated with other autoimmune disorders, and its treatment involves replacement of FVIII and various modes of immunosuppression. Recently, a few noteworthy therapeutic advances have been made. We present two cases of severe AHA in Chinese women...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28352320/fungal-infection-involvement-in-primary-biliary-cirrhosis-a-review-of-2-cases
#18
Yanyan Wang, Zheng Zhao, Hui Lu, Jianglin Zhang, Feng Huang
The present study aimed to analyze the imaging, clinical and pathological features of fungal infection involvement in primary biliary cirrhosis (PBC) by retrospectively analyzing and reviewing the features of two patients with fungal infection involvement in PBC. Both patients were female. One patient had a confirmed diagnosis of PBC. The other patient had confirmed Sjogren syndrome and PBC. The two cases of PBC were infected with fungal infection after treatment with hormonal and immunosuppressive agents. RCR of sputum confirmed Pneumocystis spp...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28348600/delivery-of-bone-marrow-derived-mesenchymal-stem-cells-improves-tear-production-in-a-mouse-model-of-sj%C3%A3-gren-s-syndrome
#19
Hema S Aluri, Mahta Samizadeh, Maria C Edman, Dillon R Hawley, Helene L Armaos, Srikanth R Janga, Zhen Meng, Victor G Sendra, Pedram Hamrah, Claire L Kublin, Sarah F Hamm-Alvarez, Driss Zoukhri
The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren's syndrome dry eye and to investigate the underlying mechanisms involved. NOD mice (n = 20) were randomized to receive i.p. injection of sterile phosphate buffered saline (PBS, control) or murine BD-MSCs (1 × 10(6) cells). Tears production was measured at baseline and once a week after treatment using phenol red impregnated threads...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28348556/t-cell-polarization-toward-th2-tfh2-and-th17-tfh17-in-patients-with-igg4-related-disease
#20
Aurélie Grados, Mikael Ebbo, Christelle Piperoglou, Matthieu Groh, Alexis Regent, Maxime Samson, Benjamin Terrier, Anderson Loundou, Nathalie Morel, Sylvain Audia, François Maurier, Julie Graveleau, Mohamed Hamidou, Amandine Forestier, Sylvain Palat, Emmanuelle Bernit, Bernard Bonotte, Catherine Farnarier, Jean-Robert Harlé, Nathalie Costedoat-Chalumeau, Frédéric Vély, Nicolas Schleinitz
IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder involving virtually every organ with a risk of organ dysfunction. Despite recent studies regarding B cell and T cell compartments, the disease's pathophysiology remains poorly understood. We examined and characterized subsets of circulating lymphocytes in untreated patients with active IgG4-RD. Twenty-eight consecutive patients with biopsy-proven IgG4-RD were included in a prospective, multicentric study. Lymphocytes' subsets were analyzed by flow cytometry, with analysis of TH1/TH2/TH17, TFH cells, and cytokine release by peripheral blood mononuclear cells...
2017: Frontiers in Immunology
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