Dengke Li, Wuyang Zhang, Weiliang Ye, Yuan Liu, Yuan Li, Yiming Wang, Bingqing Shi, Xueni Zheng, Ying An, Zhen Ma, Kaijin Hu, Hongzhi Zhou, Yang Xue
The treatment of periodontitis can be very challenging due to its complex etiologies. A new pharmacologic strategy entitled "host-modulation therapy," has been introduced to improve periodontal treatment outcomes. Supposedly, a multifunctional drug with the potential for bacterial infection prevention, host-response modulation and bone healing promotion would be a promising option for periodontitis therapy, but related studies remain substantially lacking. In this study, we successfully conjugated tetracycline with odanacatib (a selective inhibitor of cathepsin K) to construct a multifunctional drug (TC-ODN)...
2022: Frontiers in Pharmacology