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JOURNAL ARTICLE
Ran Liu, Raymond Berry, Linshu Wang, Kiran Chaudhari, Ali Winters, Yuanhong Sun, Claire Caballero, Hannah Ampofo, Yiwei Shi, Bibek Thata, Luis Colon-Perez, Nathalie Sumien, Shao-Hua Yang
Clinical studies have identified widespread white matter degeneration in ischemic stroke patients. However, contemporary research in stroke has predominately focused on the infarct and periinfarct penumbra regions. The involvement of white matter degeneration after ischemic stroke and its contribution to post-stroke cognitive impairment and dementia (PSCID) has remained less explored in experimental models. In this study, we examined the progression of locomotor and cognitive function up to 4 months after inducing ischemic stroke by middle cerebral artery occlusion in young adult rats...
March 15, 2024: Translational Stroke Research
#22
JOURNAL ARTICLE
Daria Gendosz de Carrillo, Olga Kocikowska, Małgorzata Rak, Aleksandra Krzan, Sebastian Student, Halina Jędrzejowska-Szypułka, Katarzyna Pawletko, Anetta Lasek-Bal
Reperfusion stroke therapy is a modern treatment that involves thrombolysis and the mechanical removal of thrombus from the extracranial and/or cerebral arteries, thereby increasing penumbra reperfusion. After reperfusion therapy, 46% of patients are able to live independently 3 months after stroke onset. MicroRNAs (miRNAs) are essential regulators in the development of cerebral ischemia/reperfusion injury and the efficacy of the applied treatment. The first aim of this study was to examine the change in serum miRNA levels via next-generation sequencing (NGS) 10 days after the onset of acute stroke and reperfusion treatment...
February 27, 2024: International Journal of Molecular Sciences
#23
JOURNAL ARTICLE
Wenhao Yan, Chunyang Wang, Yumei Zhao, Yingying Jiang, Ming Sun
Calpain and PARP-NF-κB signaling are reported to participate in the ischemic brain injury. In this study, it was investigated whether calpain was contributed to the neurovascular unit (NVU) damage through up-regulating PARP-NF-κB signaling during experimental ischemic stroke. Male Sprague-Dawley rats were suffered from 90 min of middle cerebral artery occlusion, followed by reperfusion. The NVU damage was evaluated by the permeability of blood-brain barrier (BBB), the degradation of proteins in extracellular matrix and tight junctions, and ultrastructural changes...
March 12, 2024: Molecular Neurobiology
#24
JOURNAL ARTICLE
Jia Nong, Patrick M Glassman, Vladimir V Shuvaev, Sahily Reyes-Esteves, Helene C Descamps, Raisa Y Kiseleva, Tyler E Papp, Mohamad-Gabriel Alameh, Ying K Tam, Barbara L Mui, Serena Omo-Lamai, Marco E Zamora, Tea Shuvaeva, Evguenia Arguiri, Xijing Gong, Taylor V Brysgel, Ai Wen Tan, Ashley G Woolfork, Aalim Weljie, Christoph A Thaiss, Jacob W Myerson, Drew Weissman, Scott E Kasner, Hamideh Parhiz, Vladimir R Muzykantov, Jacob S Brenner, Oscar A Marcos-Contreras
Effective delivery of mRNA or small molecule drugs to the brain is a significant challenge in developing treatment for acute ischemic stroke. To address the problem, we have developed targeted nanomedicine to increase drug concentrations in endothelial cells of the blood-brain barrier (BBB) of the injured brain. Inflammation during ischemic stroke causes continuous neuronal death and increase of the infarct volume. To enable targeted delivery to the inflamed BBB, we conjugated lipid nanocarriers with antibodies that bind cell adhesion molecules expressed at the BBB...
March 6, 2024: Molecular Therapy
#25
JOURNAL ARTICLE
Yue Zhang, Jiaying Li, Yongfang Zhao, Yichen Huang, Ziyu Shi, Hailian Wang, Hui Cao, Chenran Wang, Yana Wang, Di Chen, Shuning Chen, Shan Meng, Yangfan Wang, Yueyan Zhu, Yan Jiang, Ye Gong, Yanqin Gao
The accumulation of self-renewed polarized microglia in the penumbra is a critical neuroinflammatory process after ischemic stroke, leading to secondary demyelination and neuronal loss. Although known to regulate tumor cell proliferation and neuroinflammation, HDAC3's role in microgliosis and microglial polarization remains unclear. We demonstrated that microglial HDAC3 knockout (HDAC3-miKO) ameliorated poststroke long-term functional and histological outcomes. RNA-seq analysis revealed mitosis as the primary process affected in HDAC3-deficent microglia following stroke...
March 8, 2024: Science Advances
#26
JOURNAL ARTICLE
Ji-Yu Liu, Hong-Yun He, Yi-Hao Deng
Autophagy is a metabolic process in which damaged organelles, obsolete proteins, excess cytoplasmic components, and even pathogens are presented to lysosomes for degradation via autophagosomes. It includes 4 processes: the initiation of autophagy, the formation of autophagosomes, the fusion of autophagosomes with lysosomes, and the degradation and removal of autophagic substrates within autophagic lysosomes. When these processes are continuous, it is called autophagy flux. Blockage of one or certain steps in the autophagy/lysosome signaling pathway can lead to impaired autophagy flux...
February 25, 2024: Sheng Li Xue Bao: [Acta Physiologica Sinica]
#27
JOURNAL ARTICLE
Li-Na Yang, Yi Sun, Yu-Zhu Wang, Jing Wang, Yi-Sha Qi, Shan-Shan Mu, Yun-Peng Liu, Zi-Qing Zhang, Zi-Mo Chen, Xiao-Jie Wang, Wu-Xiang Xie, Chang-Wei Wei, Yang Wang, An-Shi Wu
BACKGROUND: Endovascular thrombectomy (EVT) is a standard treatment for acute ischemic stroke (AIS) with large vessel occlusion. Hypertension and increased blood pressure variability within the first 24 h after successful reperfusion are related to a higher risk of symptomatic intracerebral hemorrhage and higher mortality. AIS patients might suffer from ischemia-reperfusion injury following reperfusion, especially within 24 h. Dexmedetomidine (DEX), a sedative commonly used in EVT, can stabilize hemodynamics by inhibiting the sympathetic nervous system and alleviate ischemia-reperfusion injury through anti-inflammatory and antioxidative properties...
March 4, 2024: Trials
#28
MULTICENTER STUDY
A Onalan, E Gurkas, C K Akpinar, H Dogan, T Acar, B Acar, O Aykac, Z Uysal Kocabas, F Balgetir, A O Ozdemir
UNLABELLED: OBJECTIVE: It is known that providing recanalization alone in large vessel occlusions is not sufficient to provide a good 90-day clinical outcome. It is advocated that neuroprotection should be increased before endovascular treatment and that the penumbra should be protected from reperfusion damage after recanalization. However, the effects of blood gas parameters before and after mechanical thrombectomy on clinical outcomes are not clear. The objective of this study is to assess the effectiveness of serial blood gas measures in accurately predicting futile recanalization at an early stage...
February 2024: European Review for Medical and Pharmacological Sciences
#29
JOURNAL ARTICLE
Qian Wu, Jia-Huan Wu, Zhi-Yuan Ye, Wen She, Wen-Jie Peng, Hui-Xin Zhang, Cui Qi, Tian Tian, Xiao-Yu Hou, Jun Gao
Stroke stands as the second leading cause of death globally, surpassed only by ischemic heart disease. It accounts for 9% of total worldwide deaths. Given the swiftly evolving landscape, medical professionals and researchers are devoting increased attention to identifying more effective and safer treatments. Recent years have witnessed a focus on exosomes derived from mesenchymal stem cells cultivated under hypoxic conditions, referred to as Hypo-Exo. These specialized exosomes contain an abundance of components that facilitate the restoration of ischemic tissue, surpassing the content found in normal exosomes...
February 29, 2024: Molecular Neurobiology
#30
JOURNAL ARTICLE
Xiao-Mei Su, Dan-Shen Zhang, Nan Zhang
Astrocytes transfer extracellular functional mitochondria into neurons to rescue injured neurons after a stroke. However, there are no reports on drugs that interfere with intercellular mitochondrial transfer. Chrysophanol (CHR) was an effective drug for the treatment of cerebral ischemia-reperfusion injury (CIRI) and was selected as the test drug. The oxygen-glucose deprivation/reoxygenation (OGD/R) cell model and the middle cerebral artery occlusion animal model were established to investigate the effect of CHR on CIRI...
February 23, 2024: Biochemical and Biophysical Research Communications
#31
JOURNAL ARTICLE
Lini Fang, Yang Tao, Guoying Che, Yongzi Yun, Min Ren, Yujie Liu
BACKGROUND: Reperfusion is the most effective strategy for myocardial infarct, but induces additional injury. WD repeat and SOCS box containing protein 1 (WSB1) plays a protective role in ischemic cells. This study aims to investigate the effects of WSB1 on myocardial ischemia-reperfusion (IR) injury. METHODS: The myocardial IR was induced by left anterior descending (LAD) ligation for 45 min and subsequent reperfusion. The overexpression of WSB1 was mediated by tail vein injection of AAV9 loaded with WSB1 encoding sequence two weeks before IR surgery...
February 23, 2024: Molecular Medicine
#32
JOURNAL ARTICLE
Junghun Cho, Jinwei Zhang, Pascal Spincemaille, Hang Zhang, Thanh D Nguyen, Shun Zhang, Ajay Gupta, Yi Wang
Oxygen extraction fraction (OEF), the fraction of oxygen that tissue extracts from blood, is an essential biomarker used to directly assess tissue viability and function in neurologic disorders. In ischemic stroke, for example, increased OEF can indicate the presence of penumbra-tissue with low perfusion yet intact cellular integrity-making it a primary therapeutic target. However, practical OEF mapping methods are not currently available in clinical settings, owing to the impractical data acquisitions in positron emission tomography (PET) and the limitations of existing MRI techniques...
January 29, 2024: Bioengineering
#33
JOURNAL ARTICLE
Da Hee Jung, Jae Ho Lee, Hong Ju Lee, Jang Woo Park, Young-Jin Jung, Hwa Kyoung Shin, Byung Tae Choi
Rationale: Non-invasive transcranial direct current stimulation (tDCS), a promising stimulation tool to modulate a wide range of brain disorders, has major limitations, such as poor cortical stimulation intensity and focality. We designed a novel electrode for tDCS by conjugating a needle to a conventional ring-based high-definition (HD) electrode to enhance cortical stimulation efficacy. Method: HD-tDCS (43 µA/mm2 , charge density 51.6 kC/m2 , 20 min) was administered to male C57BL/6J mice subjected to early-stage ischemic stroke...
2024: Theranostics
#34
JOURNAL ARTICLE
M M Q Robbe, F M E Pinckaers, R J van Oostenbrugge, W H van Zwam, A A Postma
PURPOSE: After endovascular therapy (EVT) for ischemic stroke, post-EVT CT imaging often shows areas of contrast extravasation (CE) caused by blood brain barrier disruption (BBBD). Before EVT, CT-perfusion (CTP) can be used to estimate salvageable tissue (penumbra) and irrevocably damaged infarction (core). In this study, we aimed to correlate CTP deficits to CE, as a surrogate marker for BBBD, after EVT for ischemic stroke. METHODS: In this single center study, EVT patients between 2010 and 2020 in whom both CTP at baseline and DECT post-EVT was performed were included...
February 17, 2024: European Journal of Radiology
#35
JOURNAL ARTICLE
Zhifang Li, Shuai Sun, Qinghui Xiao, Senwei Tan, Huijuan Jin, Bo Hu
In ischemic stroke, neutrophils are the first-line peripheral immune cells infiltrating the brain tissue to form neutrophil extracellular traps (NETs). The present study aimed to investigate the role of neuronal cold-inducible RNA-binding protein (CIRP) in promoting NETs-induced brain endothelial barrier destruction and cerebral edema after ischemic stroke. We found that the expression of NETs and neuronal CIRP in the penumbra increased at 6 hours after transient middle cerebral artery occlusion (tMCAO) and increased significantly at 24 hours, reaching a peak at 3 days...
February 9, 2024: Aging and Disease
#36
JOURNAL ARTICLE
Jing Qiu, Yi-Han Wang, Xiu-Ming Wang, Hui-Sheng Chen
The pericytes (PCs) surrounding capillaries are vital regulators of capillary constriction. Persistent PC contraction results in the increased capillary constriction, therefore leading to the impaired cerebral blood flow (CBF) recovery after reperfusion and worsening the clinical outcomes in stroke patients. However, the potential determinants of PC functions during ischemia/reperfusion are poorly understood. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit Delta (PIK3CD/PI3Kδ) is a crucial factor involved with neuronflammation during ischemic stroke...
February 15, 2024: Experimental Neurology
#37
JOURNAL ARTICLE
Saif Bushnaq, Ameer E Hassan, Adam Delora, Ali Kerro, Anita Datta, Rime Ezzeldin, Zuhair Ali, Tunmi Anwoju, Layla Nejad, Rene Silva, Yazan Diya Abualnadi, Zorain Mustafa Khalil, Mohamad Ezzeldin
BACKGROUND AND PURPOSE: Automated CTP postprocessing packages have been developed for managing acute ischemic stroke. These packages use image processing techniques to identify the ischemic core and penumbra. This study aimed to investigate the agreement of decision-making rules and output derived from RapidAI and Viz.ai software packages in early and late time windows and to identify predictors of inadequate quality CTP studies. MATERIALS AND METHODS: One hundred twenty-nine patients with acute ischemic stroke who had CTP performed on presentation were analyzed by RapidAI and Viz...
April 4, 2024: AJNR. American Journal of Neuroradiology
#38
JOURNAL ARTICLE
Amrou Sarraj, Ameer E Hassan, Michael G Abraham, Santiago Ortega-Gutierrez, Scott E Kasner, Muhammad Shazam Hussain, Michael Chen, Leonid Churilov, Hannah Johns, Clark W Sitton, Vignan Yogendrakumar, Felix C Ng, Deep K Pujara, Spiros Blackburn, Sophia Sundararajan, Yin C Hu, Nabeel A Herial, Juan F Arenillas, Jenny P Tsai, Ronald F Budzik, William J Hicks, Osman Kozak, Bernard Yan, Dennis J Cordato, Nathan W Manning, Mark W Parsons, Andrew Cheung, Ricardo A Hanel, Amin N Aghaebrahim, Teddy Y Wu, Pere Cardona Portela, Chirag D Gandhi, Fawaz Al-Mufti, Natalia Pérez de la Ossa, Joanna D Schaafsma, Jordi Blasco, Navdeep Sangha, Steven Warach, Timothy J Kleinig, Faris Shaker, Faisal Al Shaibi, Gabor Toth, Mohammad A Abdulrazzak, Gagan Sharma, Abhishek Ray, Jeffrey Sunshine, Amanda Opaskar, Kelsey R Duncan, Wei Xiong, Edgar A Samaniego, Laith Maali, Colleen G Lechtenberg, Arturo Renú, Nirav Vora, Thanh Nguyen, Johanna T Fifi, Stavropoula I Tjoumakaris, Pascal Jabbour, Georgios Tsivgoulis, Vitor Mendes Pereira, Maarten G Lansberg, Michael DeGeorgia, Cathy A Sila, Nicholas Bambakidis, Michael D Hill, Stephen M Davis, Lawrence Wechsler, James C Grotta, Marc Ribo, Greg W Albers, Bruce C Campbell
IMPORTANCE: Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of ischemic injury is uncertain. OBJECTIVE: To describe the relationship between imaging estimates of irreversibly injured brain (core) and at-risk regions (mismatch) and clinical outcomes and EVT treatment effect. DESIGN, SETTING, AND PARTICIPANTS: An exploratory analysis of the SELECT2 trial, which randomized 352 adults (18-85 years) with acute ischemic stroke due to occlusion of the internal carotid or middle cerebral artery (M1 segment) and large ischemic core to EVT vs medical management (MM), across 31 global centers between October 2019 and September 2022...
March 5, 2024: JAMA
#39
JOURNAL ARTICLE
Jennifer N Harmon, Jeffrey E Hyde, Dylan E Jensen, Emma C D'cessare, Anton A Odarenko, Matthew F Bruce, Zin Z Khaing
Spinal cord injury is characterized by hemodynamic disruption at the injury epicenter and hypoperfusion in the penumbra, resulting in progressive ischemia and cell death. This degenerative secondary injury process has been well-described, though mostly using ex vivo or depth-limited optical imaging techniques. Intravital contrast-enhanced ultrasound enables longitudinal, quantitative evaluation of anatomical and hemodynamic changes in vivo through the entire spinal parenchyma. Here, we used ultrasound imaging to visualize and quantify subacute injury expansion (through 72 h post-injury) in a rodent cervical contusion model...
January 8, 2024: Experimental Neurology
#40
JOURNAL ARTICLE
Rui Wang, Meng Wang, Yu-Cheng Fan, Wen-Jun Wang, Deng-Hai Zhang, P Andy Li, Jian-Zhong Zhang, Li Jing
Hyperglycemia exacerbates ischemic brain injury by up-regulating autophagy. However, the underlying mechanisms are unknown. This study aims to determine whether hyperglycemia activates autophagy through the p53-Sesn2-AMPK signaling pathway. Rats were subjected to 30-min middle cerebral artery occlusion (MCAO) with reperfusion for 1- and 3-day under normo- and hyperglycemic conditions; and HT22 cells were exposed to oxygen deprivation (OG) or oxygen-glucose deprivation and re-oxygenation (OGD/R) with high glucose...
January 31, 2024: Neuroscience Letters
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