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https://www.readbyqxmd.com/read/29778519/decline-of-hpv-infections-in-scandinavian-cervical-screening-populations-after-introduction-of-hpv-vaccination-programs
#1
Joakim Dillner, Mari Nygård, Christian Munk, Maria Hortlund, Bo T Hansen, Camilla Lagheden, Kai-Li Liaw, Susanne K Kjaer
OBJECTIVE: To monitor the changes in prevalence of human papillomavirus (HPV) infections in women <50 years of age, participating in cervical screening programs of Denmark, Norway, and Sweden, before and after introduction of quadrivalent HPV (qHPV) vaccination. METHODS: Liquid-based cytology samples were collected from 6538 women who attended cervical screening in Denmark, Norway, and Sweden in 2006-2008 and from 6332 similarly enrolled women in 2012-2013...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29776329/convaq-a-web-tool-for-copy-number-variation-based-association-studies
#2
Simon Jonas Larsen, Luisa Matos do Canto, Silvia Regina Rogatto, Jan Baumbach
BACKGROUND: Copy number variations (CNVs) are large segments of the genome that are duplicated or deleted. Structural variations in the genome have been linked to many complex diseases. Similar to how genome-wide association studies (GWAS) have helped discover single-nucleotide polymorphisms linked to disease phenotypes, the extension of GWAS to CNVs has aided the discovery of structural variants associated with human traits and diseases. RESULTS: We present CoNVaQ, an easy-to-use web-based tool for CNV-based association studies...
May 18, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29774090/strong-sod2-expression-and-hpv-16-18-positivity-are-independent-events-in-cervical-cancer
#3
Silvia Helena Rabelo-Santos, Lara Termini, Enrique Boccardo, Sophie Derchain, Adhemar Longatto-Filho, Maria Antonieta Andreoli, Maria Cecília Costa, Rafaella Almeida Lima Nunes, Liliana Aparecida Lucci Ângelo-Andrade, Luisa Lina Villa, Luiz Carlos Zeferino
It is well known that persistent infection with high-risk HPV (hr-HPV), mostly HPV-16 and 18, is the main cause of cervical cancer development. Manganese superoxide dismutase (MnSOD or SOD2) are highly expressed in different neoplasia. The present study investigated SOD2 protein expression and the presence of hr-HPV types in 297 cervical samples including non-neoplastic tissue, cervical intraepithelial neoplasia grade 3 (CIN3), squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Strong SOD2 expression was significantly higher in ADC (82%) than CIN3 (52%) or SCC (64%)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29771378/detection-of-incident-anal-high-risk-hpv-dna-in-msm-incidence-or-reactivation
#4
Denise E Twisk, Marianne A B van der Sande, Arne van Eeden, Daniëlle A M Heideman, Fiona R M van der Klis, Henry J C de Vries, Maarten F Schim van der Loeff
Background: We aimed to assess whether sexual exposure may explain all incident anal HPV detections among men who have sex with men (MSM). Methods: A longitudinal study among MSM was conducted between 2010 and 2013 with six-monthly visits and up to 24 months of follow-up. Risk-factor questionnaires, blood samples, and anal and penile self-swabs were collected at each visit. Self-swabs were used for detection and genotyping of HPV by SPF10-PCR/DEIA/LiPA25 system...
May 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29768678/the-ideal-strategy-for-cervical-cancer-screening-in-japan-result-from-the-fukui-cervical-cancer-screening-study
#5
T Kurokawa, T Onuma, A Shinagawa, Y Chino, M Kobayashi, Y Yoshida
OBJECTIVE: The aims of the Fukui Cervical Cancer Screening (FCCS) study are to determine the frequency of women with high-risk HPV (hrHPV), whether HPV16 or HPV18 (HPV16/18), in the Japanese cancer screening population for the first time and to identify the best strategy for cervical cancer screening in Japan. METHODS: This study enrolled 7,584 women ≥25 years of age who were undergoing routine screening. All women underwent liquid-based cytology and cobas HPV tests...
May 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29764400/low-cost-hpv-testing-and-the-prevalence-of-cervical-infection-in-asymptomatic-populations-in-guatemala
#6
Hong Lou, Eduardo Gharzouzi, Sarita Polo Guerra, Joël Fokom Domgue, Julie Sawitzke, Guillermo Villagran, Lisa Garland, Joseph F Boland, Sarah Wagner, Héctor Rosas, Jami Troxler, Heidi McMillen, Bailey Kessing, Enrique Alvirez, Miriam Castillo, Hesler Morales, Victor Argueta, Andert Rosingh, Femke J H B van Aerde-van Nunen, Griselda Lopez, Herbert M Pinedo, Mark Schiffman, Michael Dean, Roberto Orozco
BACKGROUND: A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determine the most prevalent HPV types and the distribution of HPV infections in over 1795 cancer-free women in Guatemala undergoing primary screening for cervical cancer by cytology...
May 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29764277/human-papillomavirus-hpv-is-absent-in-branchial-cleft-cysts-of-the-neck-distinguishing-them-from-hpv-positive-cystic-metastasis
#7
Lars Sivars, David Landin, Marzia Rizzo, Linnea Haeggblom, Cinzia Bersani, Eva Munck-Wikland, Anders Näsman, Tina Dalianis, Linda Marklund
BACKGROUND: Distinguishing branchial cleft cysts (BCCs) from cystic metastases of a human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is challenging. Fine needle aspirates (FNAs) from cystic metastasis may be non-representative, while reactive squamous cells from BCC can be atypic. Based on cytology and with the support of HPV DNA positivity many centers treat cystic metastasis oncological and thus patients are spared neck dissection. To do so safely, one must investigate whether HPV DNA and p16INK4a overexpression is found exclusively in cystic metastases and not in BCC...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29763978/circulating-human-papillomavirus-dna-as-a-surveillance-tool-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#8
Kristina Kvist Jensen, Christian Grønhøj, David H Jensen, Christian von Buchwald
BACKGROUND: The incidence of human papillomavirus-induced (HPV+) head and neck squamous cell carcinoma (HNSCC) i.e. especially oropharyngeal cancers (OPSCC) is increasing and a significant proportion of patients encounter disease progression. A simple and sensitive test to identify patients with progression is an unmet need. OBJECTIVE OF REVIEW: To systematically review the literature and carry out a meta-analysis of studies, investigated circulating HPV-DNA as a biomarker for disease progression in patients with HNSCC...
May 15, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29759380/impact-of-a-clinical-interventions-bundle-on-uptake-of-hpv-vaccine-at-an-ob-gyn-clinic
#9
Uma Deshmukh, Carlos R Oliveira, Susan Griggs, Emily Coleman, Lital Avni-Singer, Shefali Pathy, Eugene D Shapiro, Sangini S Sheth
INTRODUCTION: HPV vaccine uptake is lowest among young adults. Little is known about the most effective way to decrease missed opportunities (MO) and increase uptake of the vaccine in this vulnerable population. OBJECTIVES: To determine the impact of a clinical intervention bundle on the rate of MO and uptake of the vaccine among young adult women. METHODS: From 2/2014 to 7/2015, an intervention bundle (designating physician and nurse champions, pre-screening patients' charts, empowering nurses to recommend immunization, providing no-cost vaccinations, placing prompts in clinic note templates, eliminating requirement for pre-vaccination pregnancy test) was implemented at an urban, hospital-based OB/GYN clinic...
May 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29759030/development-of-human-derived-cell-culture-lines-for-recurrent-respiratory-papillomatosis
#10
James Attra, Li-En Hsieh, Linda Luo, Jun Qin Mo, Matthew Brigger, Yu-Tsueng Liu, Seth Pransky
Recurrent respiratory papillomatosis (RRP) is mainly caused by human papillomavirus (HPV) 6 and 11. While various adjuvant therapies have been reported, no effective therapy has been documented to universally "cure" this disease. In the era of precision medicine, it would be valuable to identify effective intervention based on drug sensitivity testing and/or molecular analysis. It is essential to be able to successfully carry out in vitro culture and expand tumor cells directly from patients to accomplish this goal...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29758205/performance-of-p16-ki67-dual-staining-in-triaging-hr-hpv-positive-population-during-cervical-cancer-screening-in-the-younger-women
#11
Qiu-Ping Qian, Xiaoan Zhang, Bo Ding, Shi-Wen Jiang, Ze-Min Li, Mu-Lan Ren, Yang Shen
BACKGROUND: Cervical cancer is the most common malignancy from the female reproductive tract, and usually develops from low-grade or high-grade squamous intraepithelial lesions (LSIL or HSIL). Detecting the precancerous lesion during the LSIL-HSIL-invasive cancer sequelae can effectively interrupt the oncogenesis and decrease the incidence of invasive carcinoma. The aim of this study is to evaluate the performance of P16/Ki67 dual staining in triaging hr-HPV-positive population. METHODS: Conventional gynecological examination, cervical cytology and hr-HPV testing were given to all patients...
May 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29756652/laser-treatment-for-women-with-high-grade-vaginal-intraepithelial-neoplasia-a-propensity-matched-analysis-on-the-efficacy-of-ablative-versus-excisional-procedures
#12
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Lavinia Mosca, Valentina Chiappa, Diego Rossetti, Umberto Leone Roberti Maggiore, Ilaria Sabatrucci, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To investigate the long-term effectiveness of LASER treatment in women affected by high-grade vaginal intra-epithelial neoplasia. METHODS: Data of consecutive women treated for high-grade vaginal intra-epithelial neoplasia were retrieved. Efficacy and long-term effectiveness of ablative and excisional procedures were tested using a propensity-matched algorithm. Risk of recurrence over the time was assessed using Kaplan-Meier and Cox models. RESULTS: Overall, 204 patients met the inclusion criteria...
May 14, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29750774/genital-wart-and-human-papillomavirus-prevalence-in-men-in-the-united-states-from-penile-swabs-results-from-national-health-and-nutrition-examination-surveys
#13
Michael Daugherty, Timothy Byler
INTRODUCTION: Human papillomavirus (HPV) is a common sexually transmitted infection in the United States that can lead to both malignant (high-risk) and benign (low-risk) findings. These low-risk findings include both genital condyloma, anal warts, and adult or juvenile papillomatosis, which are directly attributable to subtypes HPV 6 and HPV 11. We aim to estimate the prevalence of genital wart infections in men in the US population using a nationwide sample. METHODS: The NHANES database was queried for all men aged 18 to 59 years during the years 2013 to 2014...
June 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29750709/classic-vulvar-intraepithelial-neoplasia-with-superimposed-lichen-simplex-chronicus-a-unique-variant-mimicking-differentiated-vulvar-intraepithelial-neoplasia
#14
Jaclyn C Watkins, Eric Yang, Christopher P Crum, Michael Herfs, Tarik Gheit, Massimo Tommasino, Marisa R Nucci
High-grade vulvar intraepithelial neoplasia, a precursor lesion to vulvar squamous cell carcinoma, is subdivided into 2 types, classic or usual vulvar intraepithelial neoplasia (CVIN) and differentiated vulvar intraepithelial neoplasia (DVIN). CVIN, which is a human papilloma virus (HPV)-dependent lesion, is typically distinguished from DVIN, a p53 mutation-dependent process, by its distinct histomorphologic and immunohistochemical characteristics. However, distinguishing between the 2 entities becomes challenging in cases of CVIN with superimposed inflammatory changes, especially lichen simplex chronicus (LSC)...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29749321/prevalence-of-the-integration-status-for-human-papillomavirus-16-in-esophageal-carcinoma-samples
#15
Shuying Li, Haie Shen, Ji Li, Xiaoli Hou, Ke Zhang, Jintao Li
BACKGROUND/AIMS: To investigate the etiology of esophageal cancer (EC) related with human papillomavirus (HPV) infection. MATERIALS AND METHODS: Fresh surgically resected tissue samples and clinical information were obtained from 189 patients. Genomic DNA was extracted, and HPV was detected using polymerase chain reaction (PCR) with HPV L1 gene primers of MY09/11; HPV16 was detected using HPV16 E6 type-specific primer sets. Copies of HPV16 E2, E6, and the human housekeeping gene β-actin were tested using quantitative PCR to analyze the relationship between HPV16 integration and esophageal squamous cell carcinoma and the relationship between the HPV16 integration status and clinical information of patients...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29747340/-the-impact-of-male-circumcision-on-the-natural-history-of-genital-hpv-infection-a-prospective-cohort-study
#16
F X Wei, M Guo, X J Ma, Y Huang, Y Zheng, L Wang, Y Sun, S J Zhuang, K Yin, Y Y Su, S J Huang, M Q Li, T Wu, J Zhang
Objective: To analyze the correlation between circumcision and incidence and clearance of male genital HPV infection. Methods: From May to July 2014, 18-55 year old men who had sexual behavior history were recruited from the general population in Liuzhou, Guangxi to set up a cohort. Totally, 113 circumcised and 560 uncircumcised men were enrolled and interviewed using a questionnaire (including information on demographic characteristics and sexual behaviors), then they were followed-up with 6-month interval for 2 times...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29747339/-distribution-and-associated-factors-of-high-risk-hpv-genotypes-infection-among-hpv-positive-women-who-participated-cervical-screening-test-in-shenzhen-2014-2016-china
#17
Y Y Wang, W Lin, B Wu, S X Yuan, J L Yao, X S Zhao, B Chen, Y L Qiao, F H Zhao, W Chen, S Y Hu, Z H Liu
Objective: To analyze the distribution and associated factors of high-risk genotypes of HPV in cervical infection among women in Shenzhen. Methods: The information on sociodemographic characteristics and HPV genotypes of HPV-positive women who participated cervical screening test from January 2014 to December 2016 was downloaded from Shenzhen Maternity and Child Healthcare Management Information System. According to the pathogenicity, the high-risk HPV genotypes were divided into 15 types including HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68; and there were 6 low-risk genotypes including HPV 6, 11, 42, 43, 44, and 81...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29747338/-role-of-hpv-viral-loads-in-random-biopsy-under-normal-colposcopy
#18
X Q Xu, L Zhang, S Y Hu, Remila Rezhake, X L Zhao, F Chen, X Zhang, Q J Pan, Y L Qiao, F H Zhao
Objective: To explore the role of HPV viral loads in random biopsy under normal colposcopy. Methods: 908 atypical squamous cells of undetermined significance (ASC-US) and HPV positive women, recruited in cluster sampling in 9 provinces including 5 urban areas and 9 rural areas in China from 1999 to 2008 and meeting the inclusion and exclusion criteria were included in this analysis. According to relative light units/cutoff (RLU/CO) value, subjects were stratified as low (286 cases), intermediate (311 cases) and high (311 cases) viral load groups...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29747337/-comparison-of-screening-performance-between-primary-high-risk-hpv-screening-and-high-risk-hpv-screening-plus-liquid-based-cytology-cotesting-in-diagnosis-of-cervical-precancerous-or-cancerous-lesions
#19
X L Zhao, Rezhake Remila, S Y Hu, L Zhang, X Q Xu, F Chen, Q J Pan, X Zhang, F H Zhao
Objective: To evaluate and compare the screening performance of primary high-risk HPV(HR-HPV) screening and HR-HPV screening plus liquid-based cytology (LBC) cotesting in diagnosis of cervical cancer and precancerous lesions (CIN2+). Methods: We pooled 17 population-based cross-sectional studies which were conducted across China from 1999 to 2008. After obtaining informed consent, all women received liquid-based cytology(LBC)testing, HR-HPV DNA testing. Totally 28 777 women with complete LBC, HPV and biopsy results were included in the final analysis...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29746625/extended-human-papillomavirus-genotype-distribution-and-cervical-cytology-results-in-a-large-cohort-of-chinese-women-with-invasive-cervical-cancers-and-high-grade-squamous-intraepithelial-lesions
#20
Wei Jiang, R Marshall Austin, Lei Li, Kaixuan Yang, Chengquan Zhao
Objectives: To study the human papillomavirus (HPV) genotype distribution of cervical cancer (CxCa) and cervical intraepithelial neoplasia grade 2/3 (CIN2/3) in China and to evaluate cotesting of HPV and cytology in CxCa screening. Methods: Patients with histopathologic CxCa and CIN 2/3 diagnoses reported between January 2012 and June 2016 and extended HPV genotype testing in the prior 6 months were documented in the institute. Available prior Papanicolaou (Pap) test results were also documented...
April 16, 2018: American Journal of Clinical Pathology
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