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https://www.readbyqxmd.com/read/28340235/polymerase-chain-reaction-human-papillomavirus-hpv-detection-and-hpv-genotyping-in-invasive-cervical-cancers-with-prior-negative-hc2-test-results
#1
Xiang Tao, Baowen Zheng, Fufen Yin, Zhengyu Zeng, Zaibo Li, Christopher C Griffith, Bing Luo, Xiangdong Ding, Xianrong Zhou, Chengquan Zhao
Objectives: Recently, three large Chinese cohort studies showed that 7.5% to 15.5% of patients with cervical carcinoma had negative high-risk human papillomavirus (hrHPV) test results on prior cytology specimens. These studies raise the question as to whether these negative hrHPV results represent truly hrHPV-negative carcinomas or false-negative hrHPV test results due to limitations in the testing of cytology specimens. This is increasingly an important question with increasing push to use hrHPV testing alone to screen for cervical cancer...
March 15, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28332888/clinician-and-patient-acceptability-of-self-collected-human-papillomavirus-testing-for-cervical-cancer-screening
#2
Constance Mao, Shalini L Kulasingam, Hilary K Whitham, Stephen E Hawes, John Lin, Nancy B Kiviat
BACKGROUND: To evaluate clinician and patient attitudes toward home self-collected human papillomavirus (HPV) testing for cervical cancer screening. METHODS: Women aged 21-65 years were recruited for a randomized trial comparing home self-collected HPV testing to standard clinician-collected Pap screening. Participants were surveyed about their attitudes toward self-collected HPV testing. Clinicians performing cervical cancer screening in University of Washington medical clinics were also surveyed to determine their acceptability of self-collected HPV testing...
March 23, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28328841/increased-hpv-l1-gene-methylation-and-multiple-infection-status-lead-to-the-difference-of-cervical-epithelial-cell-lesion-in-different-ethnic-women-of-xinjiang-china
#3
Feng Yang-Chun, Zhang Yuan, Liu Cheng-Ming, Huang Yan-Chun, Ma Xiu-Min
Human papillomavirus (HPV) L1 gene methylation deeply involved in the progression and heterogeneity of cervical cell epithelial lesions. The DNA ploidy also represented the early lesions of cervical cell, and it was associated with different HPV infection status in different ethnic women. So, the research was to explore whether it was possible that HPV L1 gene methylation and HPV infection status as the risk factors to lead to the differences of cervical epithelial cells' lesions in different ethnics women...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28325688/current-and-emerging-molecular-tests-for-human-papillomavirus-related-neoplasia-in-the-genomic-era
#4
REVIEW
Sixto M Leal, Margaret L Gulley
Laboratory tests have a key role in preventing human papillomavirus (HPV)-driven carcinomas and in guiding therapeutic interventions. An understanding of the virology, immunology, and carcinogenesis of HPV is essential for choosing appropriate diagnostic test modalities and developing new and even more effective cancer prevention strategies. HPV infects basal epithelial cells on multiple surfaces and induces carcinoma primarily in the cervix and the oropharynx. HPV types are stratified as high risk or low risk based on their carcinogenic potential, driven largely by viral interference with cell cycle regulation and the DNA damage response to promote continuous cell division while thwarting apoptosis, which enables mutation accumulation...
March 18, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28324192/the-presence-of-human-papillomavirus-hpv-in-placenta-and-or-cord-blood-might-result-in-th2-polarization
#5
H-M Koskimaa, A Paaso, M J P Welters, S Grénman, K Syrjänen, S H van der Burg, S Syrjänen
The purpose of this study was to evaluate if an early exposure to human papillomavirus (HPV) during the prenatal period or infancy could result in HPV16-specific T helper (Th) responses resembling those of adults with HPV-induced lesions. We tested HPV16-specific cell-mediated immunity (CMI) in children born with HPV-positive umbilical cord blood and/or placenta or having persistent oral HPV infection and in constantly oral HPV-negative controls. Peripheral blood mononuclear cells from 33 children from the Finnish HPV Family Study cohort (mean age 14...
March 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28323757/the-performance-of-human-papillomavirus-biomarkers-in-predicting-anal-high-grade-squamous-intraepithelial-lesions-in-gay-and-bisexual-men
#6
Fengyi Jin, Jennifer M Roberts, Andrew E Grulich, I Mary Poynten, Dorothy A Machalek, Alyssa Cornall, Samuel Phillips, Deborah Ekman, Ross L Mcdonald, Richard J Hillman, David J Templeton, Annabelle Farnsworth, Suzanne M Garland, Christopher K Fairley, Sepehr N Tabrizi
BACKGROUND: We evaluate the performance of human papillomavirus (HPV) biomarkers in prediction of anal histological high-grade squamous intraepithelial lesions (HSIL) in gay and bisexual men (GBM) in Sydney, Australia. DESIGN: Baseline analysis of a three-year cohort study METHODS:: The Study of the Prevention of Anal Cancer (SPANC) is natural history study of anal HPV infection in GBM aged ≥35 years. All participants completed cytological and histological assessments...
March 18, 2017: AIDS
https://www.readbyqxmd.com/read/28322534/indicators-for-monitoring-screening-programs-with-primary-hpv-test
#7
Manuel Zorzi, Paolo Giorgi Rossi
BACKGROUND: following scientific evidence produced in numerous studies, as well as national and international guidelines, organized cervical cancer screening programs in Italy have gradually introduced the HPV test as primary screening test, replacing cytology. As public health interventions, screening programs must ensure equity, improvement in quality of life, and adequate information for the population involved with regards to benefits and possible risks; therefore, it is essential for quality to be constantly checked at every phase of the project...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28321649/adolescent-participation-in-hpv-vaccine-clinical-trials-are-parents-willing
#8
Jennifer Cunningham Erves, Tilicia L Mayo-Gamble, Pamela C Hull, Lauren Duke, Stephania T Miller
Approximately one-quarter of human papillomavirus (HPV) infections are acquired by adolescents, with a higher burden among racial/ethnic minorities. However, racial/ethnic minorities have been underrepresented in previous HPV vaccine trials. Ongoing and future HPV vaccine optimization trials would benefit from racially- and ethnically-diverse sample of adolescent trial participants. This study examined factors influencing parental willingness to consent to their adolescents' participation in HPV vaccine clinical trials and tested for possible racial differences...
March 21, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28319456/reactogenicity-of-cervarix-and-gardasil-human-papillomavirus-hpv-vaccines-in-a-randomized-single-blind-trial-in-healthy-uk-adolescent-females
#9
Tao Haskins-Coulter, Jo Southern, Nick Andrews, Elizabeth Miller
One hundred and ninety eight females aged 12-15 y were enrolled in an observer-blinded randomized trial to assess the immunogenicity and reactogenicity of the tetravalent HPV vaccine Gardasil® (group 2), in comparison to the bivalent HPV vaccine, Cervarix® (group 1), which was routinely offered in the national vaccination schedule at the time. Participants were blinded to treatment group until all 3 vaccinations had been given, while laboratory staff were masked during testing. For the majority of local and general reactions, recipients of both vaccines reported comparable frequencies...
March 20, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28316071/chlamydia-trachomatis-and-hpv-co-infections-in-hiv-negative-men-from-a-multi-ethnic-area-of-northern-italy-at-high-prevalence-of-cervical-malignancies
#10
Manola Comar, Silva Seraceni, Claudia Colli, Viviana Luska, Sara Morassut, Libera Clemente, Marina Drabeni, Gianmichele Moise, Francesco Fontana, Lorenzo Monasta, Barbara Suligoi
Chlamydia trachomatis and HPV coinfections in the male population are often a disregarded issue. We performed a study to evaluate the prevalence of such infections in heterosexual HIV negative men from a Northern Italy multi-ethnic area at high prevalence for cervical malignancies. Urethral swabs (US) or first-voided urine were evaluated retrospectively from 1317 patients attending Sexually Transmitted Infections (STI) clinic and from 3388 outpatients attending private clinics. Informations about participants' demographic characteristics and attributes of Chlamydia trachomatis, including chronic infection, and HPV genotypes testing, were collected...
March 18, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28304400/evaluation-of-p16-ki-67-dual-stained-cytology-as-triage-test-for-high-risk-human-papillomavirus-positive-women
#11
Renée Mf Ebisch, Judith van der Horst, Meyke Hermsen, L Lucia Rijstenberg, Judith Em Vedder, Johan Bulten, Remko P Bosgraaf, Viola Mj Verhoef, Daniëlle Am Heideman, Peter Jf Snijders, Chris Jlm Meijer, Folkert J van Kemenade, Leon Fag Massuger, Willem Jg Melchers, Ruud Lm Bekkers, Albert G Siebers
The aim of this study was to evaluate the clinical utility of p16/Ki-67 dual staining, for the identification of CIN in high-risk HPV-positive women from a non-responder screening cohort. P16/Ki-67 dual staining, Pap cytology, and HPV16/18 genotyping were performed on physician-taken liquid-based samples from 495 women who tested high-risk HPV positive on self-sampled material (PROHTECT-3B study). Different triage strategies involving p16/Ki-67 dual staining were evaluated for sensitivity, specificity, and predictive value for ≥CIN2 and ≥CIN3, and compared to Pap cytology with a threshold of atypical cells of undetermined significance...
March 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28304083/influence-of-human-papillomavirus-on-the-clinical-presentation-of-oropharyngeal-carcinoma-in-the-united-states
#12
Matthew H Stenmark, Dean Shumway, Cui Guo, Jeffrey Vainshtein, Michelle Mierzwa, Reshma Jagsi, Jennifer J Griggs, Mousumi Banerjee
OBJECTIVE: Much of what is known about the significance of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma is derived from single-institution retrospective studies, post hoc analyses of tissue specimens from clinical trials, and tissue bank studies with a small sample size. The objective of this study is to investigate the impact of HPV on the frequency and clinical presentation of oropharyngeal carcinoma in a large, national sample with information from patients who underwent HPV testing...
March 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28303830/multiplex-polymerase-chain-reaction-for-the-detection-of-high-risk-human-papillomavirus-types-in-formalin-fixed-paraffin-embedded-cervical-tissues
#13
Mini P Singh, Nalini Gupta, T Deepak, Archit Kumar, Radha Kanta Ratho
Detecting high-risk-human papillomavirus (HPV) types has become an integral part of the cervical cancer screening programmes. This study aimed to develop a multiplex polymerase chain reaction (PCR) for identification of HPV types 16 and 18 along with the beta globin gene in formalin-fixed and paraffin-embedded cervical biopsy specimens. A total of 59 samples from patients with cervical abnormalities were tested. HPV 16 positivity was 50% in cervical cancers and 52.9% in cervical intraepithelial neoplasia. Our multiplex PCR protocol can be used as a simple and cost-effective tool for high-risk-HPV detection in cervical cancer screening programmes...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28303822/human-papillomavirus-and-chlamydia-trachomatis-infection-in-gyneco-obstetric-outpatients-from-a-mexican-hospital
#14
Laura Conde-Ferráez, Jorge Ramiro Carrillo Martíez, Guadalupe Ayora-Talavera, María Del Refugio González Losa
CONTEXT: Human papillomavirus (HPV) and Chlamydia trachomatis are the most frequent sexually transmitted infections, usually asymptomatic. Persistent infection with high-risk HPV types and other cofactors such as the concomitant infection with C. trachomatis can represent a higher risk to develop cervical lesions; therefore, screening with sensitive methods could aid to identify women at risk. AIMS: The aim is to determine the prevalence and concurrence of both infections, detected with in-house molecular methods, and to identify the risk factors associated to the infections in Mexican women...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28302536/rna-chromogenic-in-situ-hybridization-assay-with-clinical-automated-platform-is-a-sensitive-method-in-detecting-high-risk-human-papillomavirus-in-squamous-cell-carcinoma
#15
Javier E Mendez-Pena, Peter M Sadow, Vania Nose, Mai P Hoang
Detection of active human papillomavirus (HPV) is clinically important, as its presence has been shown to correlate with favorable clinical outcomes and better response to treatment in oropharyngeal squamous cell carcinomas (SCC). Using a clinical automated platform, we compared the performance of commercially available HPV DNA and RNA in situ hybridization (ISH) probes in archival tissues of 57 SCC. Importantly, a clinical automated platform gives 1) consistent and reproducible results for HPV ISH and 2) better standardization across clinical laboratories...
March 13, 2017: Human Pathology
https://www.readbyqxmd.com/read/28297074/cost-effectiveness-of-cervical-cancer-screening-methods-in-low-and-middle-income-countries-a-systematic-review
#16
REVIEW
Alex K Mezei, Heather L Armstrong, Heather N Pedersen, Nicole G Campos, Sheona M Mitchell, Musa Sekikubo, Josaphat K Byamugisha, Jane J Kim, Stirling Bryan, Gina S Ogilvie
The incidence of cervical cancer in low- and middle-income countries (LMICs) is five times higher than that observed in high-income countries (HICs). This discrepancy is largely attributed to the implementation of cytology-based screening programmes in HICs. However, due to reduced health system infrastructure requirements, HPV testing (self- and provider-collected), and visual inspection with acetic acid (VIA) have been proposed as alternatives that may be better suited to LMICs. Knowing the relative value of different screening options can inform policy and the development of sustainable prevention programs...
March 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28295222/traf3-cyld-mutations-identify-a-distinct-subset-of-human-papilloma-virus-associated-head-and-neck-squamous-cell-carcinoma
#17
Michael Hajek, Andrew Sewell, Susan Kaech, Barbara Burtness, Wendell G Yarbrough, Natalia Issaeva
BACKGROUND: The incidence of human papillomavirus (HPV)-associated (HPV-positive) head and neck squamous cell carcinoma (HNSCC) of the oropharynx has dramatically increased over the last decade and continues to rise. Newly diagnosed HPV-positive HNSCCs in the United States currently outnumber any other HPV-associated cancers, including cervical cancer. Despite introduction of the HPV vaccine, the epidemic of HPV-positive HNSCC is expected to continue for approximately 60 years. Compared with patients who have tobacco-associated HNSCC, those who have HPV-positive HNSCC have better overall survival and response to treatment...
March 13, 2017: Cancer
https://www.readbyqxmd.com/read/28294358/prevalence-of-human-papillomavirus-infection-among-chilean-women-from-2012-to-2016
#18
Nicolás Vergara, Gloria Espinoza, Monserrat Balanda, Andrea Quiero, Wilma Hidalgo, Héctor San Martín, Alejandro Ramírez, Eugenio Ramírez
Here we evaluated the prevalence of Human Papillomavirus (HPV) in two groups of Chilean women. The first group consisted of 3,235 women aged 18-64 years attended in six primary care centres of Santiago. The second group consisted of 456 women 18-85 aged who consulted the Gynaecology Department of the Reference Hospital of Santiago. Samples were collected from October 2012 to February 2016. Cervical swabs were analyzed both HPV genotyping by PCR and Reverse Line Blot, and cervical cytology by Pap testing. Results showed a prevalence of 12...
March 11, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28292201/performing-piety-in-sexual-health-research-gender-health-and-evangelical-christianities-in-a-mexican-human-papillomavirus-hpv-study
#19
Emily Wentzell
Recent research suggests that health surveillance experiences like clinical trial participation might have unanticipated social consequences. I investigate how evangelical Christians participating in longitudinal, observational sexual health research incorporate that long-term medical surveillance into their religious practice. This exploratory research focuses on Mexican Cristianos' participation in the Cuernavaca arm of the multinational 'Human Papillomavirus in Men' ('HIM') study, which tested men for the common and usually asymptomatic sexually transmitted infection human papillomavirus (HPV) over time...
March 15, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/28286668/a-protocol-for-a-cluster-randomised-feasibility-study-of-an-adolescent-incentive-intervention-to-increase-uptake-of-hpv-vaccination-among-girls
#20
Alice S Forster, Victoria Cornelius, Lauren Rockliffe, Laura A V Marlow, Helen Bedford, Jo Waller
BACKGROUND: Uptake of the human papillomavirus (HPV) vaccine in the UK is good, but there are pockets of the community who remain unprotected. Immunisation teams usually require written parental consent for a girl to receive the vaccine. Evidence suggests that uptake of the vaccine might be improved by promoting consent form return (if returned, forms are likely to grant consent). Incentivising girls to return consent forms is a promising approach to promoting consent form return. Before testing the efficacy of an incentive intervention in a randomised controlled trial (RCT), we must first establish whether the RCT is feasible...
2017: Pilot and Feasibility Studies
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