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https://www.readbyqxmd.com/read/29145648/relative-performance-of-hpv-and-cytology-components-of-cotesting-in-cervical-screening
#1
Mark Schiffman, Walter K Kinney, Li C Cheung, Julia C Gage, Barbara Fetterman, Nancy E Poitras, Thomas S Lorey, Nicolas Wentzensen, Brian Befano, John Schussler, Hormuzd A Katki, Philip E Castle
Background: The main goal of cervical screening programs is to detect and treat precancer before cancer develops. Human papillomavirus (HPV) testing is more sensitive than cytology for detecting precancer. However, reports of rare HPV-negative, cytology-positive cancers are motivating continued use of both tests (cotesting) despite increased testing costs. Methods: We quantified the detection of cervical precancer and cancer by cotesting compared with HPV testing alone at Kaiser Permanente Northern California (KPNC), where 1 208 710 women age 30 years and older have undergone triennial cervical cotesting since 2003...
November 14, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29144546/presence-of-infection-and-analysis-of-hpv-subtypes-in-girls-younger-than-9-years-old-attended-at-a-referral-service-in-esp%C3%A3-rito-santo-brazil
#2
Mariana Penha De Nadai Sartori, Lidiane Pignaton Agostini, Thaís Tristão Tovar, Raquel Silva Dos Reis, Raquel Spinassé Dettogni, Eldamária de Vargas Wolfgramm Dos Santos, Antônio Chambô Filho, Iúri Drumond Louro
PURPOSE: Human papillomavirus is found in adults and adolescents and is associated with genital warts and cervical cancer. However, it has been detected in girls younger than 10 years old. Currently, there are no prevention methods for this age group, since it is not considered a risk group. The aim of this study was to evaluate the presence of infection and HPV subtype in girls under 9 years old attended at a referral service in the State of Espírito Santo, Brazil. METHODS: Forty-three girls younger than 9 years old had gynecological brush samples collected from vulval and perineal/anal regions...
November 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29143102/diagnostic-performance-of-hpv-e6-e7-mrna-assay-for-detection-of-cervical-high-grade-intraepithelial-neoplasia-and-cancer-among-women-with-ascus-papanicolaou-smears
#3
Chenchen Ren, Yuanhang Zhu, Li Yang, Xiaoan Zhang, Ling Liu, Chunying Ren
PURPOSE: The aim of this study was to investigate the clinical performance of high risk (HR) HPV E6/E7 mRNA assay in detecting cervical high-grade intraepithelial neoplasia and cancer among women with atypical squamous cells of undetermined significance (ASCUS) Papanicolaou (Pap) smears. METHODS: A total of 160 patients with ASCUS who underwent HR-HPV DNA assay, HR-HPV E6/E7 mRNA assay and colposcopy biopsy at Third Affiliated Hospital of Zhengzhou University, China, from December 2015 to March 2017, were enrolled...
November 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29143101/candidate-biomarkers-in-the-cervical-vaginal-fluid-for-the-self-diagnosis-of-cervical-precancer
#4
REVIEW
Xaveer Van Ostade, Martin Dom, Wiebren Tjalma, Geert Van Raemdonck
PURPOSE: Despite improvement in vaccines against human papilloma virus (HPV), the causative agent of cervical cancer, screening women for cervical precancer will remain indispensable in the coming 30-40 years. A simple test that could be performed at home or at a doctor's practice and that informs the woman whether she is at risk would significantly help make a broader group of patients who aware that they need medical treatment. Cervical vaginal fluid (CVF) is a body fluid that is very well suited for such a test...
November 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29140880/high-risk-human-papillomavirus-determination-in-formalin-fixed-paraffin-embedded-cervical-tissue-using-the-roche-cobas-4800-system-a-comparative-study-with-liquid-based-cytology
#5
Juan C Tardío, Olivia Cambero, Carolina Sánchez-Estévez, Ana B Sánchez-García, Fernando Angulo, Amalia Moreno
Roche cobas 4800 human papillomavirus (HPV) test is an automated real-time polymerase chain reaction-based system that allows the simultaneous detection of 14 human papillomavirus high-risk (HR-HPV) genotypes. This test is Food and Drug Administration approved since 2011 for HPV determination in liquid-based cytologic samples, but a clinically validated technique for formalin-fixed, paraffin-embedded (FFPE) tissue specimens is presently not commercially available. In our laboratory, we have developed an HPV detection procedure in FFPE tissue by cobas 4800 HPV test...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29138009/human-papillomavirus-hpv-infection-in-females-with-normal-cervical-cytology-genotyping-and-phylogenetic-analysis-among-women-in-punjab-pakistan
#6
Hafsa Aziz, Huma Iqbal, Humera Mahmood, Shazia Fatima, Muhammad Faheem, Areej Abdul Sattar, Sobia Tabassum, Sanum Napper, Syeda Batool, Nuzhat Rasheed
OBJECTIVE: Cervical cancer is the fourth most common cancer in the world, seventh overall with account for an estimated 300,000 annual deaths. HPV is the second most common cause of cervical cancer worldwide. HPV screening is not a common practice in Pakistan. The present study aims to determine the prevalence of HPV and HPV types in females with normal cytology of cervix in Upper and Lower region of Punjab Pakistan and analyze the risk factors for HPV in this region. METHOD: In this study, we performed PCR analysis for 1011 female patients with normal cytology of cervix from various districts in Punjab Province, Pakistan and risk factors for acquisition of HPV were studied...
November 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29137390/a-cocktail-of-p16-ink4a-and-ki-67-p16-ink4a-and-minichromosome-maintenance-protein-2-as-triage-tests-for-human-papillomavirus-primary-cervical-cancer-screening
#7
Hai-Rui Wang, Yu-Cong Li, Hui-Qin Guo, Lu-Lu Yu, Zeni Wu, Jian Yin, Guang-Dong Liao, Yi-Min Qu, Yu Jiang, Dong Wang, Wen Chen
Most human papillomavirus (HPV) infections are transient and additional triage approaches should be built after HPV-based primary cervical cancer screening. We evaluated the accuracy of p16/Ki-67 and p16/mcm2 dual staining as biomarkers for triaging HPV positive women in China. 4070 participants aged 35 to 64 years attending ongoing cervical cancer screening were enrolled in 2015-2016. Cervical exfoliated cells were collected for HPV DNA analysis and the residual positive specimens were tested for liquid-based cytology and biomarkers...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136403/high-grade-cervical-intraepithelial-neoplasia-in-human-papillomavirus-self-sampling-of-screening-non-attenders
#8
J U H Lam, K M Elfström, D M Ejegod, H Pedersen, C Rygaard, M Rebolj, E Lynge, K E Juul, S K Kjær, J Dillner, J Bonde
BACKGROUND: Self-sampling for human papillomavirus (HPV) offered to women who do not participate in cervical cancer screening is an increasingly popular method to increase screening coverage. The rationale behind self-sampling is that unscreened women harbour a high proportion of undetected precancer lesions. Here, we compare the cervical intraepithelial neoplasia grade 2 or worse (⩾CIN2) detection rate between non-attenders who participated in self-sampling and women attending routine screening...
November 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29135982/sting-expression-and-response-to-treatment-with-sting-ligands-in-premalignant-and-malignant-disease
#9
Jason R Baird, Zipeng Feng, Hong D Xiao, David Friedman, Ben Cottam, Bernard A Fox, Gwen Kramer, Rom S Leidner, R Bryan Bell, Kristina H Young, Marka R Crittenden, Michael J Gough
Human papilloma virus positive (HPV+) tumors represent a large proportion of anal, vulvar, vaginal, cervical and head and neck squamous carcinomas (HNSCC) and late stage invasive disease is thought to originate from a premalignant state. Cyclic dinucleotides that activate STimulator of INterferon Genes (STING) have been shown to cause rapid regression of a range of advanced tumors. We aimed to investigate STING ligands as a novel treatment for papilloma. We tested therapies in a spontaneous mouse model of papilloma of the face and anogenital region that histologically resembles human HPV-associated papilloma...
2017: PloS One
https://www.readbyqxmd.com/read/29134823/does-self-efficacy-mediate-the-relationships-between-social-cognitive-factors-and-intentions-to-receive-hpv-vaccination-among-young-women
#10
Shannon M Christy, Joseph G Winger, Catherine E Mosher
Drawing upon health behavior change theories, the current study examined whether self-efficacy mediated relationships between social-cognitive factors (i.e., perceived risk, perceived benefits, perceived barriers, perceived severity, and cue to action) and human papillomavirus (HPV) vaccination intentions among college women. Unvaccinated women ( N = 115) aged 18 to 25 years attending a Midwestern university completed an anonymous web-based survey assessing study variables. Correlational analyses and mediation analyses were conducted...
November 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/29132873/hpv-genotype-profile-in-a-norwegian-cohort-with-asc-us-and-lsil-cytology-with-three-year-cumulative-risk-of-high-grade-cervical-neoplasia
#11
A K Lie, A Tropé, G B Skare, T Bjørge, C M Jonassen, K Brusegard, S Lönnberg
OBJECTIVE: To explore the HPVgenotype profile in Norwegian women with ASC-US/LSIL cytology and the subsequent risk of high-grade cervical neoplasia (CIN 3+). METHODS: In this observational study delayed triage of ASC-US/LSIL of 6058 women were included from 2005 to 2010. High-risk HPV detection with Hybrid Capture 2 (HC2) was used and the HC2+ cases were genotyped with in-house nmPCR. Women were followed-up for histologically confirmed CIN3+ within three years of index HPV test by linkage to the screening databases at the Cancer Registry of Norway...
November 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29131134/mannose-binding-lectin-is-not-acting-as-a-biomarker-for-the-progression-of-pre-invasive-lesions-of-invasive-cervical-cancer
#12
Carlos Afonso Maestri, Renato Nisihara, Guilherme P Ramos, Hellen Weinschutz Mendes, Iara Messias-Reason, Newton Sérgio de Carvalho
OBJECTIVE: To evaluate serum concentrations of mannose binding lectin (MBL) in women presenting with different human papilloma virus (HPV)-associated cervical lesions. SUBJECTS AND METHODS: A total of 364 women, who underwent screening for cervical cancer or treatment at Erasto Gaertner Cancer Hospital (HEG), Curitiba, Southern region, Brazil, were enrolled in the study. Based on latest cervical colposcopy-guided biopsy results, the women were divided into four groups: cervical intraepithelial neoplasia (CIN) CIN-I (n=54); CIN-II (n=72); CIN-III (n=145) and invasive cancer (n=93)...
November 7, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29130974/atypical-squamous-cells-in-liquid-based-cervical-cytology-microbiology-inflammatory-infiltrate-and-human-papillomavirus-dna-testing
#13
Geilson Gomes de Oliveira, Renata Mirian Nunes Eleutério, Ana Katherine Silveira Gonçalves, Paulo César Giraldo, José Eleutério
OBJECTIVE: The aim of this study was to assess the correlation between atypical squamous cells (ASC) and inflammatory infiltrate and vaginal microbiota using cervical liquid-based cytological (SurePath®) and high-risk human papillomavirus (HR-HPV) tests. STUDY DESIGN: A cross-sectional study was conducted using a 6-year database from a laboratory in Fortaleza (Brazil). Files from 1,346 ASC cases were divided into subgroups and results concerning inflammation and vaginal microorganisms diagnosed by cytology were compared with HR-HPV test results...
November 8, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/29130107/a-seven-gene-prognostic-signature-for-rapid-determination-of-head-and-neck-squamous-cell-carcinoma-survival
#14
Sipeng Shen, Jianling Bai, Yongyue Wei, Guanrong Wang, Qingya Li, Ruyang Zhang, Weiwei Duan, Sheng Yang, Mulong Du, Yang Zhao, David C Christiani, Feng Chen
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and displays divergent clinical outcomes. Prognostic biomarkers might improve risk stratification and survival prediction. We aimed to investigate the prognostic genes associated with overall survival. A two-step gene selection method was used to develop a seven-gene-based prognostic model based on the training set collected from The Cancer Genome Atlas (TCGA). In addition, the prognostic model was validated in an independent testing set from Gene Expression Omnibus (GEO)...
December 2017: Oncology Reports
https://www.readbyqxmd.com/read/29126708/incomplete-excision-of-cervical-precancer-as-a-predictor-of-treatment-failure-a-systematic-review-and-meta-analysis
#15
Marc Arbyn, Charles W E Redman, Freija Verdoodt, Maria Kyrgiou, Menelaos Tzafetas, Sadaf Ghaem-Maghami, Karl-Ulrich Petry, Simon Leeson, Christine Bergeron, Pekka Nieminen, Jean Gondry, Olaf Reich, Esther L Moss
BACKGROUND: Incomplete excision of cervical precancer is associated with therapeutic failure and is therefore considered as a quality indicator of clinical practice. Conversely, the risk of preterm birth is reported to correlate with size of cervical excision and therefore balancing the risk of adequate treatment with iatrogenic harm is challenging. We reviewed the literature with an aim to reveal whether incomplete excision, reflected by presence of precancerous tissue at the section margins, or post-treatment HPV testing are accurate predictors of treatment failure...
November 7, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29126556/vulvar-intraepithelial-neoplasia-risk-factors-for-recurrence
#16
W Satmary, C H Holschneider, L L Brunette, S Natarajan
OBJECTIVE: We studied a large population of women with high-grade vulvar intraepithelial neoplasia (VIN) in order to identify patient and treatment-related risk factors for recurrence and progression to cancer. METHODS: For this retrospective cohort study of women with a histologic diagnosis of VIN within Southern California Permanente Medical Group between 1995 and 2007 medical records were reviewed; clinical, demographic and pathologic data were collected. Statistical analyses included Chi-squared and Student's t-tests, univariate and multivariate logistic regression, and cumulative incidence analysis...
November 7, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29124900/unsatisfactory-exfoliative-anal-cytology-samples-15-year-experience-with-histologic-cytologic-and-molecular-follow-up
#17
Ruba Khattab, Emily McMeekin, Alan J Taege, James M Hekman, Jennifer A Brainard, Dawn Underwood, Gary W Procop, Charles D Sturgis
BACKGROUND: The incidence of anal carcinoma has risen in recent decades. Exfoliative cytology screening of selected high risk patients is performed in many centers. Unsatisfactory cytology results are frustrating to patients, clinicians, and laboratorians. The aim of this study is to ascertain outcomes of patients with non-diagnostic anal cytology. METHODS: A retrospective review of anal cytology testing performed at the Cleveland Clinic between 01/01/2001 and 12/31/2015 was performed...
November 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29124542/uptake-of-hpv-testing-and-extended-cervical-cancer-screening-intervals-following-cytology-alone-and-pap-hpv-cotesting-in-women-aged-30-65%C3%A2-years
#18
Michelle I Silver, Anne F Rositch, Darcy F Phelan-Emrick, Patti E Gravitt
OBJECTIVE: To evaluate the adoption of HPV testing and recommended extended cervical cancer screening intervals in clinical practice, we described yearly uptake of Pap/HPV cotesting and estimated length of time between normal screens by patient characteristics. METHODS: We examined 55,575 Pap/HPV records from 27,035 women aged 30-65 years from the Johns Hopkins Hospital Pathology Data System between 2006 and 2013. Cotest uptake and median times to next screening test for cotests and cytology only were calculated...
November 9, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29121873/barriers-to-hpv-self-sampling-and-cytology-among-low-income-indigenous-women-in-rural-areas-of-a-middle-income-setting-a-qualitative-study
#19
Betania Allen-Leigh, Patricia Uribe-Zúñiga, Leith León-Maldonado, Brandon J Brown, Attila Lörincz, Jorge Salmeron, Eduardo Lazcano-Ponce
BACKGROUND: Data is needed about barriers to self-collection of Human Papillomavirus (HPV) samples and cytology among low-income, disadvantaged women living in rural areas of lower-income countries as these women are at increased risk of cervical cancer mortality. METHODS: Individual interviews (n = 29), focus groups (n = 7, 5-11 participants) and discussion groups (n = 2, 18-25 participants) were organized with women from three indigenous ethnic groups residing in rural areas in Mexico, after they were provided with free, self-sampled HPV tests...
November 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29121862/human-papillomavirus-in-semen-and-the-risk-for-male-infertility-a-systematic-review-and-meta-analysis
#20
Zhangyan Lyu, Xiaoshuang Feng, Ni Li, Wei Zhao, Luopei Wei, Yuheng Chen, Wenjing Yang, Hongxia Ma, Bing Yao, Kai Zhang, Zhibin Hu, Hongbing Shen, Dong Hang, Min Dai
BACKGROUND: Human papillomavirus (HPV) is one of the most prevalent sexually transmitted viruses. Despite the increasing evidence of HPV prevalence in semen, the worldwide distribution of HPV types in semen and risk for male infertility remain inconclusive. METHODS: Four electronic databases were searched for English language studies conducted between January 1990 and December 2016 that reported HPV DNA prevalence in semen. Based on the PRISMA guidelines, HPV prevalence was estimated among general population and fertility clinic attendees, respectively, and heterogeneity testing was performed using Cochran's Q and I (2) statistics...
November 9, 2017: BMC Infectious Diseases
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