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https://www.readbyqxmd.com/read/28935832/an-electronic-trigger-based-on-care-escalation-to-identify-preventable-adverse-events-in-hospitalised-patients
#1
Viraj Bhise, Dean F Sittig, Viralkumar Vaghani, Li Wei, Jessica Baldwin, Hardeep Singh
BACKGROUND: Methods to identify preventable adverse events typically have low yield and efficiency. We refined the methods of Institute of Healthcare Improvement's Global Trigger Tool (GTT) application and leveraged electronic health record (EHR) data to improve detection of preventable adverse events, including diagnostic errors. METHODS: We queried the EHR data repository of a large health system to identify an 'index hospitalization' associated with care escalation (defined as transfer to the intensive care unit (ICU) or initiation of rapid response team (RRT) within 15 days of admission) between March 2010 and August 2015...
September 21, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28935262/identification-of-the-period-of-stability-in-a-balance-test-after-stepping-up-using-a-simplified-cumulative-sum
#2
Doha Safieddine, Aly Chkeir, Cyrille Herlem, Delphine Bera, Michèle Collart, Jean-Luc Novella, Moustapha Dramé, David J Hewson, Jacques Duchêne
Falls are a major cause of death in older people. One method used to predict falls is analysis of Centre of Pressure (CoP) displacement, which provides a measure of balance quality. The Balance Quality Tester (BQT) is a device based on a commercial bathroom scale that calculates instantaneous values of vertical ground reaction force (Fz) as well as the CoP in both anteroposterior (AP) and mediolateral (ML) directions. The entire testing process needs to take no longer than 12 s to ensure subject compliance, making it vital that calculations related to balance are only calculated for the period when the subject is static...
September 18, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28933219/suppression-of-trim32-enhances-motor-function-repair-after-traumatic-brain-injury-associated-with-antiapoptosis
#3
Zi-Bin Zhang, Liu-Lin Xiong, Bin-Tuan Lu, Hui-Xiang Zhang, Piao Zhang, Ting-Hua Wang
To investigate the role of Trim32 in traumatic brain injury (TBI), adult male Sprague Dawley (SD) rats and mice were randomly divided into sham (n = 6) and TBI groups ( n = 24), respectively. Then, mice were assigned into Trim32 knockout mice (Trim32-KO [+/-]) and wild-type (WT) littermates. The TBI model used was the Feeney free-falling model, and neurological function was evaluated after TBI using a neurological severity score (NSS). Reverse transcription polymerase chain reaction (RT-PCR), Western blot, and immunohistochemistry were used to investigate the expression of Trim32 in the damaged cortex...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28931660/predicting-epiglottic-collapse-in-patients-with-obstructive-sleep-apnoea
#4
Ali Azarbarzin, Melania Marques, Scott A Sands, Sara Op de Beeck, Pedro R Genta, Luigi Taranto-Montemurro, Camila M de Melo, Ludovico Messineo, Olivier M Vanderveken, David P White, Andrew Wellman
Obstructive sleep apnoea (OSA) is characterised by pharyngeal obstruction occurring at different sites. Endoscopic studies reveal that epiglottic collapse renders patients at higher risk of failed oral appliance therapy or accentuated collapse on continuous positive airway pressure. Diagnosing epiglottic collapse currently requires invasive studies (imaging and endoscopy). As an alternative, we propose that epiglottic collapse can be detected from the distinct airflow patterns it produces during sleep.23 OSA patients underwent natural sleep endoscopy...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28931374/effects-of-dexmedetomidine-on-tnf-%C3%AE-and-interleukin-2-in-serum-of-rats-with-severe-craniocerebral-injury
#5
Wan-Wei Jiang, Qing-Hui Wang, Ya-Jing Liao, Pai Peng, Min Xu, Li-Xin Yin
BACKGROUND: Dexmedetomidine is a highly selective adrenergic receptor agonist, which has a dose-dependent sedative hypnotic effect. Furthermore, it also has pharmacological properties, and the ability to inhibit sympathetic activity and improve cardiovascular stability during an operation. However, its protective effect on patients with severe craniocerebral injury in the perioperative period remains unclear. METHOD: Eighty adult male SD rats were used and divided into two groups (n = 40, each group): dexmedetomidine injury group (experimental group), and sodium chloride injury group (control group)...
September 20, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28924688/the-barrier-to-informed-choice-in-cancer-screening-statistical-illiteracy-in-physicians-and-patients
#6
Odette Wegwarth, Gerd Gigerenzer
An efficient health care requires both informed doctors and patients. Our current healthcare system falls short on both counts. Most doctors and patients do not understand the available medical evidence. To illustrate the extent of the problem in the setting of cancer screening: In a representative sample of some 5000 women in nine European countries, 92% overestimated the reduction of breast cancer mortality by mammography by a factor of 10-200, or did not know. For a similar sample of about 5000 men with respect to PSA screening, this number was 89%...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28918593/decline-patterns-and-risk-assessment-of-10-multi-class-pesticides-in-young-sprout-amaranth-amaranthus-mangostanus-under-greenhouse-growing-conditions
#7
In Kyung Kim, Sung-Woo Kim, A M Abd El-Aty, Md Musfiqur Rahman, Md Humayun Kabir, Han Sol Lee, Hyung Suk Chung, Ji Hoon Jeong, Ho-Chul Shin, Jae-Han Shim
The present study was designed to investigate the residual decline pattern and the risk assessment of 10 different class pesticides, namely azoxystrobin, boscalid, diazinon, diethofencarb, difenoconazole, etofenprox, flubendiamide, paclobutrazol, and pyraclostrobin in young vegetative amaranth (Amaranthus mangostanus) sprayed once or twice under greenhouse growing conditions. Field-incurred samples, collected at 3, 7, or 10 days after application of both treatments, were extracted and purified with the quick, easy, cheap, effective, rugged, and safe "QuEChERS" citrate-buffered method and analyzed with liquid chromatography-electrospray ionization tandem mass spectrometry (LC-MS/MS) in positive ion mode...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28916557/study-of-fall-risk-increasing-drugs-in-elderly-patients-before-and-after-a-bone-fracture
#8
Mónica Beunza-Sola, Ángel M Hidalgo-Ovejero, Jon Martí-Ayerdi, José Germán Sánchez-Hernández, Miguel Menéndez-García, Serafín García-Mata
BACKGROUND: Accidental falls have a significant economic and human impact. The use of certain drugs is one of the modifiable risk factors associated with these events. OBJECTIVE: The aim of this study was to determine the prevalence of use and to explore changes in treatment with fall-related drugs in patients over 65 years of age admitted as a result of a fall-related fracture. METHODS: Observational and prospective study performed in a tertiary level hospital...
September 15, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28915808/fall-prevention-is-the-stratify-tool-the-right-instrument-in-italian-hospital-inpatient-a-retrospective-observational-study
#9
Greta Castellini, Antonia Demarchi, Monica Lanzoni, Silvana Castaldi
BACKGROUND: Although several risk assessment tools are in use, uncertainties on their accuracy in detecting fall risk already exist. Choosing the most accurate tool for hospital inpatient is still a challenge for the organizations. We aimed to retrospectively assess the appropriateness of a fall risk prevention program with the STRATIFY assessment tool in detecting acute-care inpatient fall risk. METHODS: Number of falls and near falls, occurred from January 2014 to March 2015, was collected through the incident reporting web-system implemented in the hospital's intranet...
September 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28906205/preventing-cognitive-decline-and-dementia-from-cerebral-small-vessel-disease-the-laci-1-trial-protocol-and-statistical-analysis-plan-of-a-phase-iia-dose-escalation-trial-testing-tolerability-safety-and-effect-on-intermediary-endpoints-of-isosorbide-mononitrate
#10
Gordon W Blair, Jason P Appleton, Zhe Kang Law, Fergus Doubal, Katie Flaherty, Richard Dooley, Kirsten Shuler, Carla Richardson, Iona Hamilton, Yulu Shi, Michael Stringer, Julia Boyd, Michael J Thrippleton, Nikola Sprigg, Philip M Bath, Joanna M Wardlaw
Rationale The pathophysiology of most lacunar stroke, a form of small vessel disease, is thought to differ from large artery atherothrombo- or cardio-embolic stroke. Licensed drugs, isosorbide mononitrate and cilostazol, have promising mechanisms of action to support their testing to prevent stroke recurrence, cognitive impairment, or radiological progression after lacunar stroke. Aim LACI-1 will assess the tolerability, safety, and efficacy, by dose, of isosorbide mononitrate and cilostazol, alone and in combination, in patients with ischemic lacunar stroke...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28906017/assessing-recovery-of-in-vitro-steroid-production-in-male-rainbow-darter-etheostoma-caeruleum-in-response-to-municipal-wastewater-treatment-plant-infrastructure-changes
#11
Patricija Marjan, Glen J Van Der Kraak, Deborah L MacLatchy, Meghan L M Fuzzen, Leslie M Bragg, Mark E McMaster, Gerald R Tetreault, Mark R Servos
The present study examined in vitro 11-ketotestosterone and testosterone production by the testes of rainbow darter (Etheostoma caeruleum) collected from selected reference sites and downstream of two municipal wastewater treatment plants (MWWTPs, Waterloo and Kitchener) in the central Grand River (Ontario, Canada), over six years (2011 - 2016). The main objective was to investigate if infrastructure upgrades at the Kitchener MWWTP in 2012 resulted in a recovery of this response in the post-upgrade period (2013 - 2016)...
September 14, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28904702/-leprosy-in-children-in-the-region-of-thi%C3%A3-s-senegal-study-determining-whether-or-not-it-is-a-signal-of-recrudescence
#12
Pauline Dioussé, Haby Dione, Mariama Bammo, Ndiaga Gueye, Thierno Abdoul Aziz Diallo, Fatou Seck, Ramatoulaye Diagne Gueye, Mame Thierno Dieng, Fatma Sarr Fall, Moustapha Diop, Bernard Marcel Diop, Mamadou Mourtalla Ka
Leprosy is an infectious and transmissible disease. According to the WHO, the number of new cases of leprosy in children in Senegal has risen moderately since 2013. This study aimed to analyze the epidemiological, clinical, therapeutic and evolutionary features of leprosy in children in the geographical areas of two social rehabilitation villages in the region of Thiès. We conducted a retrospective study over a period of 3 years (2013-2015). All new cases of Hansen's disease aged 0 -15 years were included...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904457/delayed-orthostatic-hypotension-a-pilot-study-from-india
#13
Arun Grace Roy, Siby Gopinath, Suresh Kumar, Sudheeran Kannoth, Anand Kumar
INTRODUCTION: Orthostatic hypotension is defined as a sustained decrease in systolic blood pressure of 20 mm Hg or a decrease in diastolic blood pressure of 10 mm Hg within three minutes of standing compared with blood pressure from the sitting or supine position or by head-up tilt-table testing (1). When sustained blood pressure (BP) drop is after three minutes of upright posture it is called delayed orthostatic hypotension (delayed OH) (2). AIM OF THE STUDY: To detect the incidence of delayed orthostatic hypotension in patients referred to our autonomic lab...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28902149/highly-portable-sensor-based-system-for-human-fall-monitoring
#14
Aihua Mao, Xuedong Ma, Yinan He, Jie Luo
Falls are a very dangerous situation especially among elderly people, because they may lead to fractures, concussion, and other injuries. Without timely rescue, falls may even endanger their lives. The existing optical sensor-based fall monitoring systems have some disadvantages, such as limited monitoring range and inconvenience to carry for users. Furthermore, the fall detection system based only on an accelerometer often mistakenly determines some activities of daily living (ADL) as falls, leading to low accuracy in fall detection...
September 13, 2017: Sensors
https://www.readbyqxmd.com/read/28899619/first-do-the-experiment-do-computerised-interpretation-of-cardiotocography-and-other-widely-used-interventions-improve-newborn-outcomes
#15
REVIEW
Philip Steer
The introduction of continuous electronic fetal heart rate monitoring (EFM) in labour has coincided with a steady and remarkable fall in perinatal mortality. Whether this is cause or coincidence remains unclear because randomised trials have been underpowered. Attempts to improve the sensitivity and specificity of fetal compromise detection using fetal blood sampling and pH measurement, pulse oximetry, and fetal electrocardiogram analysis have failed to provide evidence of additional value in randomised trials...
September 9, 2017: Early Human Development
https://www.readbyqxmd.com/read/28898666/plant-strategies-for-enhancing-access-to-sunlight
#16
REVIEW
Anne-Sophie Fiorucci, Christian Fankhauser
Light is a vital resource for plants, which compete for it particularly in dense communities. Plants have multiple photosensory receptors to detect the presence of competitors and thereby adjust their growth and developmental strategies accordingly. Broadly speaking, plants fall into two categories depending on their response to shading by leaves: shade tolerant or shade avoiding. Here, we describe the photoperception mechanisms and the growth responses elicited by the neighboring vegetation in shade-avoiding plants, focusing on Arabidopsis thaliana, where these responses are best understood...
September 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28895917/uwb-monitoring-system-for-aal-applications
#17
Jerzy Kolakowski, Vitomir Djaja-Josko, Marcin Kolakowski
Independent living of elderly persons in their homes requires support that can be provided with modern assistive technologies. Monitoring of elderly persons behaviour delivers valuable information that can be used for diagnosis and detection of health problems as well as triggering alerts in emergency situations. The paper includes a description of the ultra wideband system developed within Networked InfrasTructure for Innovative home Care Solutions (NITICS) Active and Assisted Living (AAL) project. The system can be used as a component of AAL platforms...
September 12, 2017: Sensors
https://www.readbyqxmd.com/read/28894771/baseline-characteristics-of-fall-from-height-victims-presenting-to-emergency-department-a-brief-report
#18
Hamidreza Hatamabadi, Ali Arhami Dolatabadi, Batoul Atighinasab, Saeed Safari
INTRODUCTION: Trauma due to accidents or fall from height is a major cause of disability and mortality. The present study was designed aiming to evaluate the baseline characteristics of fall from height victims presenting to emergency department (ED). METHODS: This prospective cross-sectional study evaluates the baseline characteristics of fall from height cases presenting to EDs of three educational Hospitals, Tehran, Iran, during one year. Data were analyzed using SPSS 21 and presented using descriptive statistics...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28888670/reliability-validity-and-responsiveness-of-the-balance-evaluation-systems-test-bestest-in-individuals-with-multiple-sclerosis
#19
Kirsten Potter, Lisa Anderberg, Diana Anderson, Brooke Bauer, Megan Beste, Stephanie Navrat, Mohamed Kohia
BACKGROUND: The Balance Evaluation Systems Test (BESTest) measures various aspects of postural control, but little data exist in persons with multiple sclerosis (MS). The purpose of this study was to determine the psychometrics of the BESTest in MS. DESIGN: Observational study. METHODS: 21 ambulatory subjects with MS participated. In the first session, demographic data was collected; each subject completed a questionnaire of self-perceived disability level and the BESTest...
June 17, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28888045/tracking-pyrethroid-toxicity-in-surface-water-samples-exposure-dynamics-and-toxicity-identification-tools-for-laboratory-tests-with-hyalella-azteca-amphipoda
#20
Linda A Deanovic, Marie Stillway, Bruce G Hammock, Stephanie Fong, Inge Werner
Pyrethroid insecticides are commonly used in pest control and are present at toxic concentrations in surface waters of agricultural and urban areas worldwide. Monitoring is challenging due to their high hydrophobicity and low toxicity thresholds, which often fall below the detection limits of analytical methods. Standard daphnid bioassays used in surface water monitoring are not sensitive enough to protect more susceptible invertebrate species such as the amphipod, Hyalella azteca, and chemical loss during toxicity testing is of concern...
September 9, 2017: Environmental Toxicology and Chemistry
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