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https://www.readbyqxmd.com/read/29163308/disclosure-and-exposure-of-alcohol-on-social-media-and-later-alcohol-use-a-large-scale-longitudinal-study
#1
Eilin K Erevik, Torbjørn Torsheim, Cecilie S Andreassen, Øystein Vedaa, Ståle Pallesen
This article aims to investigate whether alcohol-related disclosure and exposure on social media can predict later alcohol use, and to identify covariates in these relationships. Data were collected by online surveys (two waves) among students in Bergen, Norway. The first survey was administered in fall 2015. The follow-up took place during fall 2016. A total of 5,217 students participated in both waves. The surveys included questions about demographics, personality, alcohol use, alcohol-related cognitions (e...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29161921/foam-pad-of-appropriate-thickness-can-improve-diagnostic-value-of-foam-posturography-in-detecting-postural-instability
#2
Bo Liu, Yangming Leng, Renhong Zhou, Jingjing Liu, Dongdong Liu, Jia Liu, Su-Lin Zhang, Wei-Jia Kong
OBJECTIVE: The present study investigated the effect of foam thickness on postural stability in patients with unilateral vestibular hypofunction (UVH) during foam posturography. METHODS: Static and foam posturography were performed in 33 patients (UVH group) and 30 healthy subjects (control group) with eyes open (EO) and closed (EC) on firm surface and on 1-5 foam pad(s). Sway velocity (SV) of center of pressure, standing time before falling (STBF) and falls reaction were recorded and analyzed...
November 21, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29158550/exome-pool-seq-in-neurodevelopmental-disorders
#3
Bernt Popp, Arif B Ekici, Christian T Thiel, Juliane Hoyer, Antje Wiesener, Cornelia Kraus, André Reis, Christiane Zweier
High throughput sequencing has greatly advanced disease gene identification, especially in heterogeneous entities. Despite falling costs this is still an expensive and laborious technique, particularly when studying large cohorts. To address this problem we applied Exome Pool-Seq as an economic and fast screening technology in neurodevelopmental disorders (NDDs). Sequencing of 96 individuals can be performed in eight pools of 12 samples on less than one Illumina sequencer lane. In a pilot study with 96 cases we identified 27 variants, likely or possibly affecting function...
November 20, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29155657/frontline-field-epidemiology-training-programs-as-a-strategy-to-improve-disease-surveillance-and-response
#4
A McKenzie André, Augusto Lopez, Samantha Perkins, Stephanie Lambert, Lesley Chace, Nestor Noudeke, Aissatou Fall, Biagio Pedalino
Since 1980, Field Epidemiology Training Programs (FETPs) have trained highly qualified field epidemiologists to work for ministries of health (MOH) around the world. However, the 2013-2015 Ebola epidemic in West Africa, which primarily affected Guinea, Liberia, and Sierra Leone, demonstrated a lack of field epidemiologists at the local levels. Trained epidemiologists at these levels could have detected the Ebola outbreak earlier. In 2015, the US Centers for Disease Control and Prevention (CDC) launched FETP-Frontline, a 3-month field training program targeting local MOH staff in 24 countries to augment local public health capacity...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29150438/a-pip2-derived-amplification-loop-fuels-the-sustained-initiation-of-b-cell-activation
#5
Chenguang Xu, Hengyi Xie, Xingdong Guo, Haipeng Gong, Lei Liu, Hai Qi, Chenqi Xu, Wanli Liu
Lymphocytes have evolved sophisticated signaling amplification mechanisms to efficiently activate downstream signaling after detection of rare ligands in their microenvironment. B cell receptor microscopic clusters (BCR microclusters) are assembled on the plasma membrane and recruit signaling molecules for the initiation of lymphocyte signaling after antigen binding. We identified a signaling amplification loop derived from phosphatidylinositol 4,5-biphosphate (PIP2) for the sustained B cell activation. Upon antigen recognition, PIP2 was depleted by phospholipase C-γ2 (PLC-γ2) within the BCR microclusters and was regenerated by phosphatidic acid-dependent type I phosphatidylinositol 4-phosphate 5-kinase outside the BCR microclusters...
November 17, 2017: Science Immunology
https://www.readbyqxmd.com/read/29148099/circulating-pcsk9-is-lowered-acutely-following-surgery
#6
Irena Druce, Hussein Abujrad, Seham Chaker, Hilary Meggison, Andrew Hill, Angela Raymond, Janice Mayne, Teik Chye Ooi
BACKGROUND: A decrease in serum low-density lipoprotein cholesterol (LDL-C) is well documented after acute stress. Plasma proprotein convertase subtilisin kexin 9 (PCSK9), which promotes degradation of low-density lipoprotein receptor (LDL-R) resulting in reduced plasma clearance of low-density lipoproteins (LDL) and an increase in serum LDL-C, would be predicted to decrease. Yet, a few studies have demonstrated an increase 1-8 days after acute stress. Our objective was to assess the earlier status of plasma PCSK9, within the first 24 hours of onset of stress...
November 17, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29147963/inappropriate-anticholinergic-drugs-prescriptions-in-older-patients-analysing-a-hospital-database
#7
Laurie Ferret, Gregoire Ficheur, Emeline Delaviez, Michel Luyckx, Sophie Quenton, Regis Beuscart, Emmanuel Chazard, Jean-Baptiste Beuscart
Background Although many anticholinergics are inappropriate in older patients, the prescription of these drugs in a hospital setting has not been extensively studied. Objective To describe prescriptions of anticholinergic drugs in terms of frequency, at risk situations and constipation in hospitalized, older adults. Setting Using a database from a French general hospital (period 2009-2013), we extracted information on 14,090 hospital stays by patients aged 75 and over. Methods Anticholinergic drug prescriptions were automatically detected, with a focus on prescriptions in three well-known at-risk situations: falls, dementia, and benign prostatic hyperplasia...
November 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29145557/comparative-analysis-of-the-growth-pattern-of-thyroid-cancer-in-young-patients-screened-by-ultrasonography-in-japan-after-a-nuclear-accident-the-fukushima-health-management-survey
#8
Sanae Midorikawa, Akira Ohtsuru, Michio Murakami, Hideto Takahashi, Satoru Suzuki, Takashi Matsuzuka, Hiroki Shimura, Tetsuya Ohira, Shin-Ichi Suzuki, Seiji Yasumura, Shunichi Yamashita, Hitoshi Ohto, Koichi Tanigawa, Kenji Kamiya
Importance: Thyroid cancer generally grows at a very slow rate in adults, and overdiagnosis is a global issue. However, the detection of early-stage thyroid cancer by screening is not well described in young patients. To prevent overdiagnosis, it is essential to understand the natural course of thyroid cancer growth detection by ultrasonography screening in young patients. Objective: To evaluate the natural progression of thyroid cancer in young patients. Design, Setting, and Participants: An observational study evaluated changes in the diameter of malignant or suspected malignant thyroid tumors on 2 occasions...
November 16, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29142787/sleep-apnea-symptoms-and-cardiovascular-disease-risks-among-haitian-medical-students
#9
Diana M Rosenthal, Donaldson F Conserve, Dodley Severe, Michaele A Gedeon, Ferdinand Zizi, Georges Casimir, Samy I McFarlane, Girardin Jean Louis
Sleep apnea is a prevalent sleep disorder that disproportionately affects blacks and has been previously studied among Caribbean-born blacks in Brooklyn, New York, but there has been negligible research in the Caribbean, specifically Haiti, and developing countries on this pressing health issue. A total of 373 medical students (mean age=20.6 years ± 2.3 years) from a medical school in Haiti participated in this study. Participants were administered a questionnaire assessing their sleep health and cardiovascular outcomes...
April 2017: Journal of Sleep Disorders & Therapy
https://www.readbyqxmd.com/read/29141768/rat-fall-surveillance-coupled-with-vector-control-and-community-education-as-a-plague-prevention-strategy-in-the-west-nile-region-uganda
#10
Karen A Boegler, Linda A Atiku, Russell E Enscore, Titus Apangu, Joseph Tendo Mpanga, Sarah Acayo, John Kaggwa, Paul S Mead, Brook M Yockey, Kiersten J Kugeler, Martin E Schriefer, Kalanthe Horiuchi, Kenneth L Gage, Rebecca J Eisen
Plague, primarily a disease of rodents, is most frequently transmitted by fleas and causes potentially fatal infections in humans. In Uganda, plague is endemic to the West Nile region. Primary prevention for plague includes control of rodent hosts or flea vectors, but targeting these efforts is difficult given the sporadic nature of plague epizootics in the region and limited resource availability. Here, we present a community-based strategy to detect and report rodent deaths (rat fall), an early sign of epizootics...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141719/chloroquine-primaquine-versus-chloroquine-alone-to-treat-vivax-malaria-in-afghanistan-an-open-randomized-superiority-trial
#11
Ghulam Rahim Awab, Mallika Imwong, Germana Bancone, Atthanee Jeeyapant, Nicholas P J Day, Nicholas J White, Charles J Woodrow
Afghanistan's national guidelines recommend primaquine (PQ) for radical treatment of Plasmodium vivax malaria, but this is rarely implemented because of concerns over potential hemolysis in patients who have G6PD deficiency. Between August 2009 and February 2014, we conducted an open-label, randomized controlled trial of chloroquine (CQ) alone versus chloroquine plus primaquine (0.25 mg base/kg/day for 14 days) (CQ+PQ) in patients aged 6 months and older with microscopy confirmed P. vivax infection. In the CQ+PQ group, G6PD deficiency was excluded by fluorescent spot testing...
October 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140305/probabilistic-prognosis-of-environmental-radioactivity-concentrations-due-to-radioisotopes-discharged-to-water-bodies-from-nuclear-power-plants
#12
Juan Tomás Zerquera, Juan C Mora, Beatriz Robles
Due to their very low values, the complexity of comparing the contribution of nuclear power plants (NPPs) to environmental radioactivity with modeled values is recognized. In order to compare probabilistic prognosis of radioactivity concentrations with environmental measurement values, an exercise was performed using public data of radioactive routine discharges from three representative Spanish nuclear power plants. Specifically, data on liquid discharges from three Spanish NPPs: Almaraz, Vandellós II, and Ascó to three different aquatic bodies (river, lake, and coast) were used...
November 15, 2017: Toxics
https://www.readbyqxmd.com/read/29139152/giant-intracranial-arteriovenous-malformation-as-the-focus-of-epileptic-seizures
#13
Mio Takayama, Kenji Hara, Aya Matsusue, Brian Waters, Natsuki Ikematsu, Masayuki Kashiwagi, Shin-Ichi Kubo
A man in his late thirties was found in a supine position in the hallway of his house. He had been diagnosed with epilepsy at approximately 20 years old. Since stopping treatment, epileptic events occurred more frequently and his condition deteriorated in the past 2 years. Autopsy revealed that head injuries were found on the left side of his head. A fracture from the left parietal bone to the anterior cranial fossa was also detected. A subdural hemorrhage (hematoma) spanned a wide range. A subarachnoid hemorrhage was also identified in the left parietal region...
November 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29138571/timed-up-and-go-test-combined-with-self-rated-multifactorial-questionnaire-on-falls-risk-and-sociodemographic-factors-predicts-falls-among-community-dwelling-older-adults-better-than-the-timed-up-and-go-test-on-its-own
#14
Azianah Ibrahim, Devinder Kaur Ajit Singh, Suzana Shahar, Mohd Azahadi Omar
Background: Early detection of falls risk among older adults using simple tools may assist in fall prevention strategies. The aim of this study was to identify the best parameters associated with previous falls, either the timed up and go (TUG) test combined with sociodemographic factors and a self-rated multifactorial questionnaire (SRMQ) on falls risk or the TUG on its own. Falls risk was determined based on parameters associated with previous falls. Design: This was a retrospective cohort study...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29135513/collection-of-nasal-secretions-and-tears-and-their-use-in-allergology
#15
Sveva Castelli, Stefania Arasi, Ruby Pawankar, Paolo M Matricardi
PURPOSE OF REVIEW: The identification of immunological markers in nasal secretions and tears is becoming essential in the study of allergic diseases. The collection procedure of nasal and ocular secretions directly influences the results, thus it is of paramount importance to validate and standardize the sampling process. RECENT FINDINGS: Current techniques for nasal secretions sampling are mainly based on three principles: collection of spontaneous secretions, nasal washings, and absorption...
November 14, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29132660/-remote-assistance-in-the-home-for-fall-detection
#16
Anne-Marie Georgelin
Remote assistance first appeared in the 1970s and the equipment has since evolved. Today, 20% of falls in elderly people aged 80 or over are detected by a remote assistance call. There are obstacles to the development of this system, notably the stigmatisation of old age and frailty. There is also the coexistence of the fear of disturbing neighbours, a feeling of an invasion of freedom and a certain fatality. Above all, remote assistance must remain an individual choice.
November 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/29127555/continuous-monitoring-of-blood-pressure-by-analyzing-the-blood-flow-sound-of-arteriovenous-fistula-in-hemodialysis-patients
#17
Yuka Kamijo, Eiichiro Kanda, Hayato Horiuchi, Noriyuki Kounoue, Keisuke Ono, Keizo Maeda, Akane Yanai, Kazuya Honda, Ryuji Tsujimoto, Mai Yanagi, Yoshitaka Ishibashi, Masayuki Yoshida
BACKGROUND: Patients with end-stage renal disease undergoing hemodialysis (HD) have an elevated risk of cardiovascular disease-related morbidity and mortality. To prevent from such a life-threatening event, the continuous blood pressure (BP) monitoring system may contribute to detect BP decline in early stages and may help to do appropriate disposal. Our research team has introduced an electronic stethoscope (Asahi Kasei Co, Ltd., Tokyo, Japan), which translates sound intensity of Arteriovenous Fistula (AVF) to BP data using the technique of Fourier transformation that can predict continuous BP non-invasively...
November 10, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29127251/looking-beyond-the-indication-bone-scan-for-trauma-providing-unsuspected-initial-diagnosis-of-acute-critical-lower-limb-arterial-compromise
#18
Fathima Fijula Palot Manzil, Samuel E Almodovar, Pradeep Bhambhvani
We report a case of rare incidental initial detection of unsuspected arterial supply compromise to the right lower extremity on a bone scan done to rule out fracture in a patient with right hip pain following a fall. Follow up CT angiogram confirmed near complete occlusion of right lower extremity arteries for which patient underwent above knee amputation.
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29126322/characterization-of-odorant-receptors-from-a-non-ditrysian-moth-eriocrania-semipurpurella-sheds-light-on-the-origin-of-sex-pheromone-receptors-in-lepidoptera
#19
Jothi Kumar Yuvaraj, Jacob A Corcoran, Martin N Andersson, Richard D Newcomb, Olle Anderbrant, Christer Löfstedt
Pheromone receptors (PRs) are essential in moths to detect sex pheromones for mate finding. However, it remains unknown from which ancestral proteins these specialized receptors arose. The oldest lineages of moths, so-called non-ditrysian moths, use short-chain pheromone components, secondary alcohols, or ketones, so called Type 0 pheromones that are similar to many common plant volatiles. It is, therefore, possible that receptors for these ancestral pheromones evolved from receptors detecting plant volatiles...
November 1, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29121156/labeling-the-lines-a-test-of-a-six-mechanism-model-of-chromatic-detection
#20
Timothy G Shepard, Safiya I Lahlaf, Rhea T Eskew
Six linear chromatic mechanisms are sufficient to account for the pattern of threshold elevations produced by chromatic noise masking in the (L,M) plane of cone space (Shepard, Swanson, McCarthy, & Eskew, 2016). Here, we report results of asymmetric color matching of the threshold-level tests from that detection study and use those matches to test the detection model. We assume the mechanisms are univariant labeled lines (Rushton, 1972; Watson & Robson, 1981), implying that the chromaticities of physically different stimuli that are detected by a single mechanism should all be the same-they are postreceptoral metamers-but the chromaticities of two stimuli detected by different mechanisms should be different...
November 1, 2017: Journal of Vision
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