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https://www.readbyqxmd.com/read/28644378/an-energy-efficient-multi-tier-architecture-for-fall-detection-using-smartphones
#1
M Amac Guvensan, A Oguz Kansiz, N Cihan Camgoz, H Irem Turkmen, A Gokhan Yavuz, M Elif Karsligil
Automatic detection of fall events is vital to providing fast medical assistance to the causality, particularly when the injury causes loss of consciousness. Optimization of the energy consumption of mobile applications, especially those which run 24/7 in the background, is essential for longer use of smartphones. In order to improve energy-efficiency without compromising on the fall detection performance, we propose a novel 3-tier architecture that combines simple thresholding methods with machine learning algorithms...
June 23, 2017: Sensors
https://www.readbyqxmd.com/read/28640712/detection-of-wellfleet-bay-virus-antibodies-in-sea-birds-of-the-northeastern-united-states
#2
Jennifer R Ballard, Randall Mickley, Justin D Brown, Nichola J Hill, Jonathan A Runstadler, Daniel E Clark, Julie C Ellis, Daniel G Mead, John R Fischer
Wellfleet Bay virus (WFBV) is a recently described orthomyxovirus isolated from the tissues of Common Eiders (Somateria mollissima) collected during recurrent mortality events on Cape Cod, Massachusetts, USA. Coastal Massachusetts is the only location where disease or mortality associated with this virus has been detected in wild birds, and a previous seroprevalence study found a significantly higher frequency of viral exposure in eiders from this location than from other areas sampled in North America. This suggests that coastal Massachusetts is an epicenter of WFBV exposure, but the reason for this is unknown...
June 22, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28640606/pharmacokinetics-of-mequindox-and-its-marker-residue-1-4-bisdesoxymequindox-in-swine-following-multiple-oral-gavage-and-intramuscular-administration-an-experimental-study-coupled-with-population-physiologically-based-pharmacokinetic-modeling
#3
Dongping Zeng, Zhoumeng Lin, Binghu Fang, Miao Li, Ronette Gehring, Jim E Riviere, ZhenLing Zeng
Mequindox (MEQ) is a quinoxaline-N,N-dioxide antibiotic used in food-producing animals. MEQ residue in animal-derived foods is a food safety concern. The tissue distribution of MEQ and its marker residue 1,4-bisdesoxymequindox (M1) was determined in swine following oral gavage or intramuscular injection twice daily for 3 days. The experimental data were used to construct a flow-limited physiologically based pharmacokinetic (PBPK) model. The model predictions correlated with available data well. Monte Carlo analysis showed that the times needed for M1 concentrations to fall below limit of detection (5 µg/kg) in liver for the 99th percentile of the population were 27 and 34 days after oral gavage and intramuscular administration twice daily for 3 days, respectively...
June 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28640437/repeated-evolution-of-vertebrate-pollination-syndromes-in-a-recently-diverged-andean-plant-clade
#4
Laura P Lagomarsino, Elisabeth J Forrestel, Nathan Muchhala, Charles C Davis
While specialized interactions, including those involving plants and their pollinators, are often invoked to explain high species diversity, they are rarely explored at macroevolutionary scales. We investigate the dynamic evolution of hummingbird and bat pollination syndromes in the centropogonid clade (Lobelioideae: Campanulaceae), an Andean-centered group of ∼550 angiosperm species. We demonstrate that flowers hypothesized to be adapted to different pollinators based on flower color fall into distinct regions of morphospace, and this is validated by morphology of species with known pollinators...
June 22, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28638845/detection-of-the-northeastern-african-rift-valley-fever-virus-lineage-during-the-2015-outbreak-in-mauritania
#5
Ndeye Sakha Bob, Hampâté Bâ, Gamou Fall, Elkhalil Ishagh, Mamadou Y Diallo, Abdourahmane Sow, Pape Mbacké Sembene, Ousmane Faye, Brahim El Kouri, Mohamed Lemine Sidi, Amadou Alpha Sall
BACKGROUND: Rift Valley fever (RVF) is an acute viral anthropozoonosis that causes epizootics and epidemics among livestock population and humans. Multiple emergences and reemergences of the virus have occurred in Mauritania over the last decade. This article describes the outbreak that occurred in 2015 in Mauritania and reports the results of serological and molecular investigations of blood samples collected from suspected RVF patients. METHODS: An RVF outbreak was reported from 14 September to 26 November 2015 in Mauritania...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28638405/a-combined-one-class-svm-and-template-matching-approach-for-user-aided-human-fall-detection-by-means-of-floor-acoustic-features
#6
Diego Droghini, Daniele Ferretti, Emanuele Principi, Stefano Squartini, Francesco Piazza
The primary cause of injury-related death for the elders is represented by falls. The scientific community devoted them particular attention, since injuries can be limited by an early detection of the event. The solution proposed in this paper is based on a combined One-Class SVM (OCSVM) and template-matching classifier that discriminate human falls from nonfalls in a semisupervised framework. Acoustic signals are captured by means of a Floor Acoustic Sensor; then Mel-Frequency Cepstral Coefficients and Gaussian Mean Supervectors (GMSs) are extracted for the fall/nonfall discrimination...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28636636/sensiscreen%C3%A2-kras-exon-2-sensitive-simplex-and-multiplex-real-time-pcr-based-assays-for-detection-of-kras-exon-2-mutations
#7
Alice Riva, Michael BØrgesen, Mariann Guldmann-Christensen, Majbritt Hauge Kyneb, Kirsten Voogd, Christina Andersen, Samantha Epistolio, Elisabetta Merlo, Tine Yding Wolff, Stephen Hamilton-Dutoit, Jan Lorenzen, Ulf Bech Christensen, Milo Frattini
Activating mutations in codon 12 and codon 13 of the KRAS (Kirsten rat sarcoma viral oncogene homolog) gene are implicated in the development of several human cancer types and influence their clinical evaluation, treatment and prognosis. Numerous different methods for KRAS genotyping are currently available displaying a wide range of sensitivities, time to answer and requirements for laboratory equipment and user skills. Here we present SensiScreen® KRAS exon 2 simplex and multiplex CE IVD assays, that use a novel real-time PCR-based method for KRAS mutation detection based on PentaBase's proprietary DNA analogue technology and designed to work on standard real-time PCR instruments...
2017: PloS One
https://www.readbyqxmd.com/read/28631766/-postural-effect-in-patients-with-patent-foramen-ovale-evaluation-of-right-to-left-shunt-with-transcranial-doppler-and-transthoracic-echocardiography-and-correlation-with-arterial-oxygen-saturation
#8
Stefano Lucreziotti, Chiara Debenedetti, Laura Massironi, Antonio Mantero, Fabiano Di Marco, Massimo Chessa, Stefano Carugo
BACKGROUND: Transcranial Doppler echocardiography and transthoracic echocardiography may detect with high accuracy right-to-left shunt (RLS) due to patent foramen ovale (PFO). However, a standardized diagnostic protocol has never been established. It has been suggested that standing or sitting positions may improve sensitivity of transcranial Doppler due to increased LRS in such positions. We aimed to test efficacy of the sitting position in addition to the supine position in the grading of RLS in patients with PFO...
June 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28630462/identification-and-molecular-characterization-of-non-polio-enteroviruses-from-children-with-acute-flaccid-paralysis-in-west-africa-2013-2014
#9
Maria D Fernandez-Garcia, Ousmane Kebe, Aichatou D Fall, Kader Ndiaye
Besides polioviruses, non-polio enteroviruses (NPEVs) may also be associated with acute flaccid paralysis (AFP). Because poliomyelitis is on the verge of eradication, more attention should be paid to study NPEVs from non-polio AFP cases and their epidemic patterns. In West African countries the epidemiology of NPEVs remains largely unexplored. We investigated the genetic diversity, frequency, circulation patterns, and molecular epidemiology of NPEVs in seven West African countries by analyzing retrospectively a panel of 3195 stool samples from children with AFP collected through routine poliomyelitis surveillance activities between 2013 and 2014...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28628549/a-classification-system-to-guide-physical-therapy-management-in-huntington-disease-a-case-series
#10
Nora E Fritz, Monica Busse, Karen Jones, Hanan Khalil, Lori Quinn
BACKGROUND AND PURPOSE: Individuals with Huntington disease (HD), a rare neurological disease, experience impairments in mobility and cognition throughout their disease course. The Medical Research Council framework provides a schema that can be applied to the development and evaluation of complex interventions, such as those provided by physical therapists. Treatment-based classifications, based on expert consensus and available literature, are helpful in guiding physical therapy management across the stages of HD...
July 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28628313/tunneling-kinetics-and-non-adiabatic-proton-coupled-electron-transfer-in-proteins-the-effect-of-electric-fields-and-anharmonic-donor-acceptor-interactions
#11
Bridget Salna, Abdelkrim Benabbas, Douglas Russo, Paul M Champion
A proper description of proton donor-acceptor (D-A) distance fluctuations is crucial for understanding tunneling in proton-coupled electron transport (PCET). The typical harmonic approximation for the D-A potential results in a Gaussian probability distribution, which does not appropriately reflect the electronic repulsion forces that increase the energetic cost of sampling shorter D-A distances. Because these shorter distances are the primary channel for thermally activated tunneling, the analysis of tunneling kinetics depends sensitively on the inherently anharmonic nature of the D-A interaction...
June 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28625940/prodromal-stage-of-disease-dementia-with-lewy-bodies-how-to-diagnose-in-practice
#12
Frédéric Blanc, Marc Verny
Disease with Lewy bodies or dementia with Lewy bodies (DLB), particularly at the prodromal stage, is a complex disease to diagnose because of different clinical beginnings and variable paths in terms of clinical expression. Thus DLB can be entcountered in different input modes: mild cognitive impairment, depression, acute behavioral disorders, confusion and delirium, or sleep disorders. In the aim to better diagnose the disease, should be sought obviously to search for the key symptoms: fluctuations, hallucinations, extra-pyramidal syndrome, and REM sleep behavior disorder...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28625633/cost-effectiveness-of-implementing-computed-tomography-screening-for-lung-cancer-in-taiwan
#13
Szu-Chun Yang, Wu-Wei Lai, Chien-Chung Lin, Wu-Chou Su, Li-Jung Ku, Jing-Shiang Hwang, Jung-Der Wang
BACKGROUND: A screening program for lung cancer requires more empirical evidence. Based on the experience of the National Lung Screening Trial (NLST), we developed a method to adjust lead-time bias and quality-of-life changes for estimating the cost-effectiveness of implementing computed tomography (CT) screening in Taiwan. METHODS: The target population was high-risk (≥30 pack-years) smokers between 55 and 75 years of age. From a nation-wide, 13-year follow-up cohort, we estimated quality-adjusted life expectancy (QALE), loss-of-QALE, and lifetime healthcare expenditures per case of lung cancer stratified by pathology and stage...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28624128/facilitating-aging-in-place-a-qualitative-study-of-practical-problems-preventing-people-with-dementia-from-living-at-home
#14
Theresa Thoma-Lürken, Michel H C Bleijlevens, Monique A S Lexis, Luc P de Witte, Jan P H Hamers
Although the majority of people with dementia wish to age in place, they are particularly susceptible to nursing home admission. Nurses can play an important role in detecting practical problems people with dementia and their informal caregivers are facing and in advising them on various ways to manage these problems at home. Six focus group interviews (n = 43) with formal and informal caregivers and experts in the field of assistive technology were conducted to gain insight into the most important practical problems preventing people with dementia from living at home...
June 14, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28622789/characterization-of-the-epidemiology-of-bat-borne-rabies-in-chile-between-2003-and-2013
#15
Raul Alegria-Moran, Daniela Miranda, Matt Barnard, Alonso Parra, Lisette Lapierre
Rabies is a zoonotic disease of great impact to public health. According to the World Health Organization, the country of Chile is currently declared free from human rabies transmitted by dogs. An epidemiological characterization and description was conducted using rabies data from 2003 to 2013 held by the National Program for Prevention and Control of Rabies from the Ministry of Health, consisting of bats samples reported as suspect and samples taken by active surveillance (bats brain tissue). Spatial autocorrelation analysis was performed using Local Indicators of Spatial Association (LISA) statistics, particularly Moran's I index, for the detection of spatial clusters...
August 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28621709/an-unobtrusive-fall-detection-and-alerting-system-based-on-kalman-filter-and-bayes-network-classifier
#16
Jian He, Shuang Bai, Xiaoyi Wang
Falls are one of the main health risks among the elderly. A fall detection system based on inertial sensors can automatically detect fall event and alert a caregiver for immediate assistance, so as to reduce injuries causing by falls. Nevertheless, most inertial sensor-based fall detection technologies have focused on the accuracy of detection while neglecting quantization noise caused by inertial sensor. In this paper, an activity model based on tri-axial acceleration and gyroscope is proposed, and the difference between activities of daily living (ADLs) and falls is analyzed...
June 16, 2017: Sensors
https://www.readbyqxmd.com/read/28621259/clinical-effectiveness-and-cost-effectiveness-of-a-multifaceted-podiatry-intervention-for-falls-prevention-in-older-people-a-multicentre-cohort-randomised-controlled-trial-the-reducing-falls-with-orthoses-and-a-multifaceted-podiatry-intervention-trial
#17
Sarah Cockayne, Sara Rodgers, Lorraine Green, Caroline Fairhurst, Joy Adamson, Arabella Scantlebury, Belen Corbacho, Catherine E Hewitt, Kate Hicks, Robin Hull, Anne-Maree Keenan, Sarah E Lamb, Caroline McIntosh, Hylton B Menz, Anthony Redmond, Zoe Richardson, Wesley Vernon, Judith Watson, David J Torgerson
BACKGROUND: Falls are a serious cause of morbidity and cost to individuals and society. Evidence suggests that foot problems and inappropriate footwear may increase the risk of falling. Podiatric interventions could help reduce falls; however, there is limited evidence regarding their clinical effectiveness and cost-effectiveness. OBJECTIVES: To determine the clinical effectiveness and cost-effectiveness of a multifaceted podiatry intervention for preventing falls in community-dwelling older people at risk of falling, relative to usual care...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28620354/torpor-the-rise-and-fall-of-3-monoiodothyronamine-from-brain-to-gut-from-gut-to-brain
#18
REVIEW
Hartmut H Glossmann, Oliver M D Lutz
3-Monoiodothyronamine (T1AM), first isolated from rat brain, is reported to be an endogenous, rapidly acting metabolite of thyroxine. One of its numerous effects is the induction of a "torpor-like" state in experimental animals. A critical analysis of T1AM, to serve as an endogenous cryogen, is given. The proposed biosynthetic pathway for formation of T1AM, which includes deiodinases and ornithine decarboxylase in the upper intestinum, is an unusual one. To reach the brain via systemic circulation, enterohepatic recycling and passage through the liver may occur...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28617240/what-carcinoembryonic-antigen-level-should-trigger-further-investigation-during-colorectal-cancer-follow-up-a-systematic-review-and-secondary-analysis-of-a-randomised-controlled-trial
#19
Bethany Shinkins, Brian D Nicholson, Tim James, Indika Pathiraja, Sian Pugh, Rafael Perera, John Primrose, David Mant
BACKGROUND: Following primary surgical and adjuvant treatment for colorectal cancer, many patients are routinely followed up with blood carcinoembryonic antigen (CEA) testing. OBJECTIVE: To determine how the CEA test result should be interpreted to inform the decision to undertake further investigation to detect treatable recurrences. DESIGN: Two studies were conducted: (1) a Cochrane review of existing studies describing the diagnostic accuracy of blood CEA testing for detecting colorectal recurrence; and (2) a secondary analysis of data from the two arms of the FACS (Follow-up After Colorectal Surgery) trial in which CEA testing was carried out...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28616852/ultrasonographic-prediction-of-highly-aggressive-telomerase-reverse-transcriptase-tert-promoter-mutated-papillary-thyroid-cancer
#20
Tae Hyuk Kim, Chang-Seok Ki, Soo Yeon Hahn, Young Lyun Oh, Hye Won Jang, Sun Wook Kim, Jae Hoon Chung, Jung Hee Shin
PURPOSE: Telomerase reverse transcriptase promoter mutations are found in highly aggressive thyroid malignancies. Our aim was to define the ultrasonographic features of telomerase reverse transcriptase promoter-mutated papillary thyroid cancer and to evaluate their predictive performances. METHODS: Ultrasonographic findings were reviewed for 185 patients with surgically confirmed papillary thyroid cancer between 1994 and 2004. Genomic DNA to identify telomerase reverse transcriptase promoter mutations was extracted from archived surgical specimens...
June 14, 2017: Endocrine
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