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https://www.readbyqxmd.com/read/28080991/minimizing-fungal-disease-deaths-will-allow-the-unaids-target-of-reducing-annual-aids-deaths-below-500-000-by-2020-to-be-realized
#1
REVIEW
David W Denning
Deaths from AIDS (1 500 000 in 2013) have been falling more slowly than anticipated with improved access to antiretroviral therapy. Opportunistic infections account for most AIDS-related mortality, with a median age of death in the mid-30s. About 360 000 (24%) of AIDS deaths are attributed to tuberculosis. Fungal infections deaths in AIDS were estimated at more than 700 000 deaths (47%) annually. Rapid diagnostic tools and antifungal agents are available for these diseases and would likely have a major impact in reducing deaths...
December 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28079645/the-role-of-patient-navigators-in-building-a-medical-home-for-multiply-diagnosed-hiv-positive-homeless-populations
#2
Mariana Sarango, Alexander de Groot, Melissa Hirschi, Chukwuemeka Anthony Umeh, Serena Rajabiun
CONTEXT: People living with human immunodeficiency virus (HIV) (PLWH) who are most at risk for falling out of HIV primary care and detectable viral loads include homeless and unstably housed individuals and those codiagnosed with behavioral health disorders. The patient-centered medical home (PCMH) is a model that promotes provision of comprehensive, patient-centered, accessible, coordinated, and quality care for patients. This initiative provided patient navigation to HIV-positive homeless and unstably housed individuals codiagnosed with a mental health or substance use disorder as a means to create an adapted PCMH to meet the specific needs of this population...
January 11, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28079632/interrater-and-test-retest-reliability-and-minimal-detectable-change-of-the-balance-evaluation-systems-test-bestest-and-subsystems-with-community-dwelling-older-adults
#3
Elizabeth Wang-Hsu, Susan S Smith
BACKGROUND AND PURPOSE: Falls are a common cause of injuries and hospital admissions in older adults. Balance limitation is a potentially modifiable factor contributing to falls. The Balance Evaluation Systems Test (BESTest), a clinical balance measure, categorizes balance into 6 underlying subsystems. Each of the subsystems is scored individually and summed to obtain a total score. The reliability of the BESTest and its individual subsystems has been reported in patients with various neurological disorders and cancer survivors...
January 10, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28076861/potential-applications-of-smart-multifunctional-wearable-materials-to-gerontology
#4
David G Armstrong, Bijan Najafi, Mohsen Shahinpoor
Smart multifunctional materials can play a constructive role in addressing some very important aging-related issues. Aging affects the ability of older adults to continue to live safely and economically in their own residences for as long as possible. Thus, there will be a greater need for preventive, acute, rehabilitative, and long-term health care services for older adults as well as a need for tools to enable them to function independently during daily activities. The objective of this paper is, thus, to present a comprehensive review of some potential smart materials and their areas of applications to gerontology...
January 12, 2017: Gerontology
https://www.readbyqxmd.com/read/28073650/the-utilisation-of-one-district-hospital-emergency-department-by-people-with-parkinson-s-disease
#5
Marion Harris, Margaret Fry
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder in Australia and the economic burden is more than $8.3 billion a year and predicted to escalate. However, little is known of the trends and characteristics of people with Parkinson's disease presenting to emergency departments (ED). METHOD: The study design was a 12 month retrospective medical record audit. The study was conducted in one metropolitan 300 bed district hospital in an outer suburb of Sydney...
January 7, 2017: Australasian Emergency Nursing Journal: AENJ
https://www.readbyqxmd.com/read/28071960/community-based-prevalence-study-of-rheumatic-heart-disease-in-rural-ethiopia
#6
Tadesse Gemechu, Hani Mahmoud, Eldryd Ho Parry, David Iw Phillips, Magdi H Yacoub
Background Chronic Rheumatic Heart disease (RHD) continues to be a health problem in many low and middle income countries and especially in sub-Saharan Africa. Echocardiography has shown that the disease is far more widespread than may be detected by clinical assessment, but data are lacking on the prevalence and epidemiological features in rural Africa. Design Community-based prevalence survey Methods We used transthoracic echocardiography to carry out a population-based study of RHD in a rural area of Ethiopia...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28070883/pilot-of-a-computerised-antithrombotic-risk-assessment-tool-version-2-caratv2-0-for-stroke-prevention-in-atrial-fibrillation
#7
Yishen Wang, Beata Bajorek
BACKGROUND: The decision-making process for stroke prevention in atrial fibrillation (AF) requires a comprehensive assessment of risk vs. benefit and an appropriate selection of antithrombotic agents (e.g., warfarin, non-vitamin K antagonist oral anticoagulants [NOACs]). The aim of this pilot-test was to examine the impact of a customised decision support tool - the Computerised Antithrombotic Risk Assessment Tool (CARATV2.0) using antithrombotic therapy on a cohort of patients with AF...
January 10, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28070457/the-concurrent-validity-and-reliability-of-the-leg-motion-system-for-measuring-ankle-dorsiflexion-range-of-motion-in-older-adults
#8
Carlos Romero Morales, César Calvo Lobo, David Rodríguez Sanz, Irene Sanz Corbalán, Beatriz Ruiz Ruiz, Daniel López López
BACKGROUND: New reliable devices for range of motion (ROM) measures in older adults are necessary to improve knowledge about the functional capability in this population. Dorsiflexion ROM limitation is associated with ankle injuries, foot pain, lower limb disorders, loss of balance, gait control disorders and fall risk in older adults. The aim of the present study was to assess the validity and reliability of the Leg Motion device for measuring ankle dorsiflexion ROM in older adults. METHODS: Adescriptive repeated-measures study was designed to test the reliability of Leg Motion in thirty-three healthy elderly patients older than 65 years...
2017: PeerJ
https://www.readbyqxmd.com/read/28069160/implementing-lung-cancer-screening-the-us-experience
#9
REVIEW
D R Aberle
The reduced lung cancer mortality observed with low-dose computed tomography (LDCT) screening in the National Lung Screening Trial (NLST) has led to annual screening in the United States as a covered benefit by both private insurers and the federal health insurance programme, the Centers for Medicare and Medicaid Services. Reimbursement for screening requires data submission to a federal registry on all individuals, whether privately or federally insured. Data must document individual patient eligibility as well as shared decision-making regarding the benefits and risks of LDCT screening, smoking cessation counselling, and the importance of annual screening...
January 6, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28068555/activity-concentration-measurements-of-selected-radionuclides-in-seals-from-canadian-arctic
#10
Jing Chen, Weihua Zhang, Baki Sadi, Xiaowa Wang, Derek C G Muir
The activity concentrations of naturally occurring radionuclides (such as (226)Ra, (210)Pb and (210)Po) and long lived (137)Cs were measured in a total of 119 tissue samples (43 blubber, 43 liver, and 33 muscle samples) from 40 ringed seals and 4 bearded seals collected in the Arviat area of Canada during the fall of 2014. Activity concentration of (210)Po was measured in all seal liver and muscle samples individually. The average (210)Po activity concentrations were 25 ± 7.6 Bq/kg fresh weight (fw) in muscle and 211 ± 58 Bq/kg fw in liver for ringed seals, and 20 ± 6...
January 6, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28065199/long-term-effectiveness-of-plasma-derived-hepatitis-b-vaccine-22-28-years-after-immunization-in-a-hepatitis-b-virus-endemic-rural-area-is-an-adult-booster-dose-needed
#11
H Li, G J Li, Q Y Chen, Z L Fang, X Y Wang, C Tan, Q L Yang, F Z Wang, F Wang, S Zhang, S L Bi, L P Shen
Longan County is considered a highly endemic area for hepatitis B virus (HBV). The plasma-derived vaccine has been used in newborns in this area since 1987. A cross-sectional survey was conducted to evaluate the long-term effectiveness of this vaccine. In total, 1634 participants born during 1987-1993 and who had received a series of plasma-derived HB vaccinations at ages 0, 1, and 6 months were enrolled. Serological HBV markers were detected and compared with previous survey data. Overall the prevalence of hepatitis B surface antigen (HBsAg) in all participants was 3·79%; 3·47% of subjects who had received the first dose within 24 h were HBsAg positive, and 8·41% of subjects who had received a delayed first dose were also HBsAg positive...
January 9, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28064358/incipient-progressive-supranuclear-palsy-is-more-common-than-expected-and-may-comprise-clinicopathological-subtypes-a-forensic-autopsy-series
#12
Koji Yoshida, Yukiko Hata, Koshi Kinoshita, Shutaro Takashima, Kortaro Tanaka, Naoki Nishida
We investigated 998 serial Japanese forensic autopsy cases (0-101 years old, mean age 61.7 ± 21.9), with no case selection, using immunohistochemistry to detect cases with progressive supranuclear palsy (PSP). Twenty-nine cases (mean age 82.3 ± 7.2 years, 11 males, 18 females) fulfilled the National Institute of Neuronal Disorders and Stroke (NINDS)-PSP pathological criteria (2.9% of all cases, 4.6% of cases over 60). All had neuronal and glial inclusions in the basal ganglia and brainstem. However, 13 cases had low tau pathology and were categorized as atypical PSP...
January 7, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28064066/plasma-pcsk9-measurement-by-liquid-chromatography-tandem-mass-spectrometry-and-comparison-with-conventional-elisa
#13
Mikaël Croyal, Fanta Fall, Michel Krempf, Aurélie Thédrez, Khadija Ouguerram, Véronique Ferchaud-Roucher, Audrey Aguesse, Stéphanie Billon-Crossouard, Pedro Mata, Rodrigo Alonso, Gilles Lambert, Estelle Nobécourt
The combination of liquid chromatography-tandem mass spectrometry (LC-MS/MS) and trypsin proteolysis is an effective tool for accurate quantitation of multiple proteins in a single run. However, expensive samples pre-treatment as immunoenrichment are often required to analyze low abundant proteins. Plasma proprotein convertase subtilisin/kexin type 9 (PCSK9), a circulating regulator of low-density lipoprotein metabolism, was studied as an example of a low abundant plasma protein. We investigated post-proteolysis solid-phase extraction (SPE) as an alternative strategy to improve its detection...
December 31, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28058484/hoverboards-spectrum-of-injury-and-association-with-an-uncommon-fracture
#14
Andrew H Schapiro, Neil U Lall, Christopher G Anton, Andrew T Trout
BACKGROUND: Self-balancing electric scooters, commonly known as hoverboards, are a new and popular consumer item with recognized fall hazards. The spectrum of injuries associated with hoverboard use has not been studied. OBJECTIVE: The purpose of this study is to determine the spectrum of radiologically apparent injuries associated with hoverboard use. MATERIALS AND METHODS: We retrospectively reviewed all imaging studies interpreted at our institution for hoverboard-related injuries during an 8-month period...
January 6, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28053509/involvement-of-the-end-user-exploration-of-older-people-s-needs-and-preferences-for-a-wearable-fall-detection-device-a-qualitative-descriptive-study
#15
Friederike Js Thilo, Selina Bilger, Ruud Jg Halfens, Jos Mga Schols, Sabine Hahn
PURPOSE: To explore the needs and preferences of community-dwelling older people, by involving them in the device design and mock-up development stage of a fall detection device, consisting of a body-worn sensor linked to a smartphone application. PATIENTS AND METHODS: A total of 22 community-dwelling persons 75 years of age and older were involved in the development of a fall detection device. Three semistructured focus group interviews were conducted. The interview data were analyzed using qualitative descriptive analysis with deductive coding...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28049489/evidence-of-non-plasmodium-falciparum-malaria-infection-in-k%C3%A3-dougou-s%C3%A3-n%C3%A3-gal
#16
Rachel F Daniels, Awa Bineta Deme, Jules F Gomis, Baba Dieye, Katelyn Durfee, Julie I Thwing, Fatou B Fall, Mady Ba, Medoune Ndiop, Aida S Badiane, Yaye Die Ndiaye, Dyann F Wirth, Sarah K Volkman, Daouda Ndiaye
BACKGROUND: Expanded malaria control efforts in Sénégal have resulted in increased use of rapid diagnostic tests (RDT) to identify the primary disease-causing Plasmodium species, Plasmodium falciparum. However, the type of RDT utilized in Sénégal does not detect other malaria-causing species such as Plasmodium ovale spp., Plasmodium malariae, or Plasmodium vivax. Consequently, there is a lack of information about the frequency and types of malaria infections occurring in Sénégal...
January 3, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28048917/su-f-j-201-validation-study-of-proton-radiography-against-ct-data-for-quantitative-imaging-of-anatomical-changes-in-head-and-neck-patients
#17
A Hammi, D Weber, A Lomax
PURPOSE: In clinical pencil-beam-scanned (PBS) proton therapy, the advantage of the characteristic sharp dose fall-off after the Bragg Peak (BP) becomes a disadvantage if the BP positions of a plan's constituent pencil beams are shifted, eg.due to anatomical changes. Thus, for fractionated PBS proton therapy, accurate knowledge of the water equivalent path length (WEPL) of the traversed anatomy is critical. In this work we investigate the feasibility of using 2D proton range maps (proton radiography, PR) with the active-scanning gantry at PSI...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046853/su-f-j-200-an-improved-method-for-event-selection-in-compton-camera-imaging-for-particle-therapy
#18
D Mackin, S Beddar, J Polf, S Peterson, E Draeger
PURPOSE: The uncertainty in the beam range in particle therapy limits the conformality of the dose distributions. Compton scatter cameras (CC), which measure the prompt gamma rays produced by nuclear interactions in the patient tissue, can reduce this uncertainty by producing 3D images confirming the particle beam range and dose delivery. However, the high intensity and short time windows of the particle beams limit the number of gammas detected. We attempt to address this problem by developing a method for filtering gamma ray scattering events from the background by applying the known gamma ray spectrum...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045040/the-fall-of-sleep-k-complex-in-alzheimer-disease
#19
Luigi De Gennaro, Maurizio Gorgoni, Flaminia Reda, Giulia Lauri, Ilaria Truglia, Susanna Cordone, Serena Scarpelli, Anastasia Mangiaruga, Aurora D'atri, Giordano Lacidogna, Michele Ferrara, Camillo Marra, Paolo Maria Rossini
Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated to β-amyloid deposition and impaired hippocampal memory consolidation. We hypothesize that the apparent contradiction may be explained by the partial overlap between 0.6-1 Hz EEG activity and K-Complex (KC)...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28044398/examining-the-validity-and-sensitivity-to-change-of-the-5-and-10-sit-to-stand-tests-in-people-with-multiple-sclerosis
#20
Ylva Nilsagård, Malin Andreasson, Anna Carling, Helena Vesterlin
BACKGROUND AND PURPOSE: Sit-to-stand transfers are frequently performed, and transfers have been associated with fall risk among people with multiple sclerosis (PwMS). There is limited research regarding the validity of sit-to-stand tests (STSs) in PwMS. The purpose of this study was to investigate the concurrent, divergent, and discriminant validity and sensitivity to change of the 5 and 10 STSs. METHODS: A repeated-measurement design was used, with data collected before and directly after a 7-week intervention, as well as prospectively reported near-fall incidents and falls during a 14-week period...
January 3, 2017: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
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