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https://www.readbyqxmd.com/read/29035595/the-influence-of-physical-qualities-on-activity-profiles-of-female-australian-football-match-play
#1
Georgia M Black, Tim J Gabbett, Rich D Johnston, Michael H Cole, Geraldine Naughton, Brian Dawson
PURPOSE: The rapid transition of female Australian football players from amateur to semi-elite competitions has the potential for athletes to be underprepared for match-play. To gain an understanding the match demands of female football, the aims of this study were three-fold: (1) to highlight the physical qualities that discriminate selected and non-selected female Australian Football players, (2) to investigate activity profiles of female Australian Football players, and (3) to gain an understanding of the influence of physical qualities on running performance in female Australian Football match-play...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29034317/luciferase-shrna-presents-off-target-effects-on-voltage-gated-ion-channels-in-mouse-hippocampal-pyramidal-neurons
#2
Yuto Hasegawa, Wenjie Mao, Sucharita Saha, Georgia Gunner, Jenya Kolpakova, Gilles E Martin, Kensuke Futai
RNA interference (RNAi) is a straightforward approach to study gene function from the in vitro cellular level to in vivo animal behavior. Although RNAi-mediated gene knockdown has become essentially routine in neuroscience over the past ten years, off-target effects of short hairpin RNAs (shRNAs) should be considered as the proper choice of control shRNA is critical in order to perform meaningful experiments. Luciferase shRNA (shLuc), targeting firefly luciferase, and scrambled shRNAs (shScrs) have been widely used as controls for vertebrate cell research...
September 2017: ENeuro
https://www.readbyqxmd.com/read/29033784/top-down-control-of-visual-attention-by-the-prefrontal-cortex-functional-specialization-and-long-range-interactions
#3
REVIEW
Sofia Paneri, Georgia G Gregoriou
The ability to select information that is relevant to current behavioral goals is the hallmark of voluntary attention and an essential part of our cognition. Attention tasks are a prime example to study at the neuronal level, how task related information can be selectively processed in the brain while irrelevant information is filtered out. Whereas, numerous studies have focused on elucidating the mechanisms of visual attention at the single neuron and population level in the visual cortices, considerably less work has been devoted to deciphering the distinct contribution of higher-order brain areas, which are known to be critical for the employment of attention...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29033137/the-global-problem-of-early-deaths-in-acute-promyelocytic-leukemia-a-strategy-to-decrease-induction-mortality-in-the-most-curable-leukemia
#4
REVIEW
A P Jillella, V K Kota
Acute promyelocytic leukemia (APL) is a hyper-acute illness and presents with profound cytopenias in most patients and disseminated intravascular coagulation (DIC). Excellent treatment options are now available with drugs such as all-trans retinoic acid (ATRA), arsenic trioxide (ATO), anthracyclines and cytarabine. The outcome in APL has improved tremendously in the last 50years due to better understanding of the disease, development of effective targeted agents and improvement in supportive care. Carefully selected groups of patients treated in large multi-center trials on a protocol and in experienced centers have shown survival rates in excess of 85%...
September 18, 2017: Blood Reviews
https://www.readbyqxmd.com/read/29031321/patients-experience-of-decision-making-and-receiving-information-during-radiation-therapy-a-qualitative-study
#5
Sian K Smith, Django Nathan, Jennifer Taylor, Eleni Van Gelder, Ann Dixon, Georgia K B Halkett, Christopher Milross, Haryana M Dhillon
PURPOSE: This study aimed to explore: (i) patient perceptions of how they are involved in treatment decisions about radiation therapy; (ii) patient knowledge and understanding of treatment; and (iii) what patients value in their interactions with the radiation therapy treatment team. METHOD: Patients were recruited through radiation oncology departments at metropolitan hospital sites located in Sydney, New South Wales, Australia. Semi-structured interviews were conducted with 21 radiation therapy patients with different types of cancer...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29030136/implementation-of-a-sentinel-surveillance-system-for-influenza-like-illness-ili-and-severe-acute-respiratory-infection-sari-in-the-country-of-georgia-2015-2016
#6
Giorgi Chakhunashvili, Abram L Wagner, Ann Machablishvili, Irakli Karseladze, Olgha Tarkhan-Mouravi, Khatuna Zakhashvili, Paata Imnadze, Matthew L Boulton
OBJECTIVES: Due to reports of substandard influenza preparedness, the country of Georgia developed two influenza surveillance systems. This paper describes these surveillance systems in their capacity to detect influenza. METHODS: Two surveillance systems for influenza operate in Georgia: an influenza-like illness (ILI) sentinel surveillance system for out-patient cases, based in the capital, Tbilisi, and a severe acute respiratory infection (SARI) sentinel surveillance system for in-patient cases with five sentinel sites - one in Tbilisi, and four in Kutaisi...
October 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29029680/long-term-effectiveness-of-treatment-as-usual-couple-therapy-for-military-veterans
#7
Kathryn M Nowlan, Emily J Georgia, Brian D Doss
Despite the fact that veterans face increased psychological and relationship distress as a result of their service-related experiences, no study to date has explored the long-term effectiveness of couple therapy for veterans. In the present investigation, 238 individuals (113 couples and 12 additional individuals) completed assessments 18 months after termination of treatment-as-usual couple therapy at two Veteran Administration Medical Centers. From pretreatment to 18-month follow-up, couples experienced significant increases in relationship satisfaction (d = 0...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29029385/analyses-of-germline-variants-associated-with-ovarian-cancer-survival-identify-functional-candidates-at-the-1q22-and-19p12-outcome-loci
#8
Dylan M Glubb, Sharon E Johnatty, Michael C J Quinn, Tracy A O'Mara, Jonathan P Tyrer, Bo Gao, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Ignace Vergote, Digna R Velez Edwards, Alicia Beeghly-Fadiel, Javier Benitez, Maria J Garcia, Marc T Goodman, Pamela J Thompson, Thilo Dörk, Matthias Dürst, Francesmary Modungo, Kirsten Moysich, Florian Heitz, Andreas du Bois, Jacobus Pfisterer, Peter Hillemanns, Beth Y Karlan, Jenny Lester, Ellen L Goode, Julie M Cunningham, Stacey J Winham, Melissa C Larson, Bryan M McCauley, Susanne Krüger Kjær, Allan Jensen, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Helga B Salvesen, Line Bjorge, Penny M Webb, Peter Grant, Tanja Pejovic, Melissa Moffitt, Claus K Hogdall, Estrid Hogdall, James Paul, Rosalind Glasspool, Marcus Bernardini, Alicia Tone, David Huntsman, Michelle Woo, Aocs Group, Anna deFazio, Catherine J Kennedy, Paul D P Pharoah, Stuart MacGregor, Georgia Chenevix-Trench
We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functional genetic analyses indicated that MEF2D and ZNF100 are targets of candidate outcome variants at 1q22 and 19p12, respectively. At 19p12, the chromatin interaction of a putative regulatory element with the ZNF100 promoter region correlated with candidate outcome variants...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028999/control-of-pecan-weevil-with-microbial-biopesticides
#9
David I Shapiro-Ilan, Ted E Cottrell, Clive Bock, Kim Mai, Debbie Boykin, Lenny Wells, William G Hudson, Russell F Mizell
The pecan weevil, Curculio caryae (Horn) (Coleoptera: Curculionidae), is a key pest of pecans Carya illinoinensis ([Wangenh.] K. Koch) (Fagales: Juglandaceae). Control recommendations rely on broad spectrum chemical insecticides. Due to regulatory and environmental concerns, effective alternatives for C. caryae control must be sought for pecan production in conventional and organic systems. We explored the use of microbial biopesticides for control of C. caryae in Georgia pecan orchards. Three experiments were conducted...
September 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29025946/complete-genome-sequence-of-peste-des-petits-ruminants-virus-from-georgia-2016
#10
Paulina Z Rajko-Nenow, Tabitha G Cunliffe, John T Flannery, Honorata M Ropiak, Lasha Avaliani, Marina Donduashvili, Michael D Baron, Carrie A Batten
We report here the complete genome sequence of a peste des petits ruminants virus (PPRV) from the first outbreak of the disease in Georgia in January 2016. Genome sequencing was performed using Illumina next-generation sequencing technology in conjunction with Sanger sequencing. This PPRV/Georgia/Tbilisi/2016 genome sequence clustered within lineage IV PPRV viruses.
October 12, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29025556/patients-with-brugada-syndrome-and-implanted-cardioverter-defibrillators-long-term-follow-up
#11
Jaime Hernandez-Ojeda, Elena Arbelo, Roger Borras, Paola Berne, Jose M Tolosana, Andrea Gomez-Juanatey, Antonio Berruezo, Oscar Campuzano, Georgia Sarquella-Brugada, Lluis Mont, Ramon Brugada, Josep Brugada
BACKGROUND: Implantable cardioverter-defibrillator (ICD) indications for primary prevention in Brugada syndrome (BrS) are still debated. OBJECTIVES: The authors investigated the long-term outcome after ICD implantation in a large cohort of BrS patients. METHODS: Of a total of 370 patients with BrS in follow-up (age 43 ± 14 years; 74% male), 104 patients (28.1%) were treated with ICDs. The authors analyzed the long-term incidence of shocks and complications...
October 17, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29024660/amyloid-beta-peptides-block-new-synapse-assembly-by-nogo-receptor-mediated-inhibition-of-t-type-calcium-channels
#12
Yanjun Zhao, Sivaprakash Sivaji, Michael C Chiang, Haadi Ali, Monica Zukowski, Sareen Ali, Bryan Kennedy, Alex Sklyar, Alice Cheng, Zihan Guo, Alexander K Reed, Ravindra Kodali, Jennifer Borowski, Georgia Frost, Patrick Beukema, Zachary P Wills
Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present evidence that neurons exposed to Aβ are unable to form new synapses, resulting in learning deficits in vivo. We demonstrate the Nogo receptor family (NgR1-3) acts as Aβ receptors mediating an inhibition of synapse assembly, plasticity, and learning...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/29024518/cd5-b-lymphoproliferative-disorder-with-subsequent-development-of-plasma-cell-leukaemia-diagnostic-and-aetiologic-reasoning
#13
Evdoxia Gounari, Georgia Kaiafa, Triantafyllia Koletsa, Vasiliki Tsavdaridou, Ioannis Kostopoulos, Lilian Toptsi, Lemonia Skoura
BACKGROUND: Plasma cell myeloma (PCM) has been sporadically reported to occur simultaneously or subsequently to mature B lymphoproliferative disorders (LPDs), predominantly chronic lymphocytic leukaemia (CLL). METHODS: We describe the clinical and laboratory findings of a 69-year-old male patient who developed plasma cell leukaemia (PCL) 8 years after an initial diagnosis of a low stage CD5+ B LPD and 3 years after treatment for LPD. RESULTS: The transition from a clinically indolent B LPD to an aggressive PCM was documented by bone marrow (BM) biopsy, while flow cytometric (FC) immunophenotyping conferred additional information by disclosing the co-existence of both disorders in BM and the presence of abnormal monotypic PCs in peripheral blood above PCL levels...
October 10, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29024351/what-are-women-told-when-requesting-family-planning-services-at-clinics-associated-with-catholic-hospitals-a-mystery-caller-study
#14
Maryam Guiahi, Stephanie B Teal, Maryke Swartz, Sandy Huynh, Georgia Schiller, Jeanelle Sheeder
CONTEXT: Catholic Church directives restrict family planning service provision at Catholic health care institutions. It is unclear whether obstetrics and gynecology clinics that are owned by or have business affiliations with Catholic hospitals offer family planning appointments. METHODS: Mystery callers phoned 144 clinics nationwide that were found on Catholic hospital websites between December 2014 and February 2016, and requested appointments for birth control generally, copper IUD services specifically, tubal ligation and abortion...
October 12, 2017: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/29024079/the-preadolescent-acne-microbiome-a-prospective-randomized-pilot-study-investigating-characterization-and-effects-of-acne-therapy
#15
Carrie C Coughlin, Shane M Swink, Joseph Horwinski, Georgia Sfyroera, Julia Bugayev, Elizabeth A Grice, Albert C Yan
BACKGROUND/OBJECTIVES: Acne, a common pediatric disease, tends to be more comedonal in preadolescents, whereas older individuals are more likely to have inflammatory lesions in addition to comedones. Thus the microbiome of preadolescents may be different. In this pilot study we aimed to characterize the preadolescent acne microbiome, compare the microbiome in preadolescents with and without acne, and investigate changes in the microbiome after topical treatment with benzoyl peroxide or a retinoid in a small cohort of preadolescents...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29023141/sexual-identity-disclosure-and-awareness-of-hiv-prevention-methods-among-black-men-who-have-sex-with-men
#16
Ryan J Watson, Jessica N Fish, Aerielle Allen, Lisa Eaton
Black men who have sex with men (BMSM) are disproportionately affected by the human immunodeficiency virus (HIV) epidemic, yet we know little about how HIV-negative BMSM of different sexual orientations access HIV prevention strategies. Identity development, minority stress, and disclosure theories suggest that for people of different sexual orientations, disclosure of sexual identity may be related to health behaviors. We performed a latent class analysis on a sample of 650 BMSM (Mage = 33.78, SD = 11...
October 12, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29022409/bilateral-transient-osteoporosis-of-the-hip-in-pregnancy
#17
Nikolaos Thanatsis, Georgia Kollia, John Gkliatis, George Decavalas, George Adonakis
No abstract text is available yet for this article.
October 12, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29021402/hiv-exposed-infants-vaccinated-with-a-mf59-rgp120-vaccine-have-higher-magnitude-anti-v1v2-igg-responses-than-adults-immunized-with-the-same-vaccine
#18
Erin P McGuire, Youyi Fong, Christopher Toote, Coleen K Cunningham, Elizabeth J McFarland, William Borkowsky, Susan Barnett, Hannah L Itell, Amit Kumar, Glenda Gray, M Julianna McElrath, Georgia D Tomaras, Sallie R Permar, Genevieve G Fouda
In the RV144 vaccine trial, IgG responses against the HIV envelope variable loops 1 and 2 (V1V2) were associated with decreased HIV acquisition risk. We previously reported that infants immunized with a MF59 adjuvanted rgp120 vaccine developed higher magnitude anti-V1V2 IgG responses than adult RV144 vaccinees. To determine if the robust antibody response in infants is due to differences in vaccine regimens or to inherent differences between the adult and infant immune systems, we compared Env-specific IgG responses in adults and infants immunized with the same MF59 and Alum adjuvanted HIV envelope vaccines...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29021394/hiv-1-gp120-protein-and-mvagp140-boost-immunogens-increase-immunogenicity-of-a-dna-mva-hiv-1-vaccine
#19
Xiaoying Shen, Rahul Basu, Sheetal Sawant, David Beaumont, Sue Fen Kwa, Celia LaBranche, Kelly E Seaton, Nicole L Yates, David C Montefiori, Guido Ferrari, Linda S Wyatt, Bernard Moss, S Munir Alam, Barton F Haynes, Georgia D Tomaras, Harriet L Robinson
An important goal of human immunodeficiency virus (HIV) vaccine design is identification of strategies that elicit effective antiviral humoral immunity. One novel approach comprises priming with DNA and boosting with modified vaccinia Ankara (MVA) expressing HIV-1 Env on virus like particles. Here we evaluated whether the addition of a gp120 protein in alum or MVA expressed secreted gp140 (MVAgp140) could improve immunogenicity of a DNA prime - MVA boost vaccine. Five rhesus macaques per group received two DNA primes at weeks 0 and 8 followed by three MVA boosts (with or without additional protein or MVAgp140) at weeks 18, 26 and 40...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29020173/time-to-sputum-culture-conversion-and-treatment-outcomes-among-patients-with-isoniazid-resistant-tuberculosis-in-atlanta-georgia
#20
Marcos C Schechter, Destani Bizune, Michelle Kagei, Mamuka Machaidze, David P Holland, Alawode Oladele, Yun F Wang, Paulina A Rebolledo, Susan M Ray, Russell R Kempker
Background: Although isoniazid-resistant tuberculosis is more common than multidrug-resistant tuberculosis, it has been much less studied. We examined the impact of isoniazid resistance and treatment regimen, including use of a fluoroquinolone, on clinical outcomes. Methods: A retrospective cohort study among patients with sputum culture-positive tuberculosis was performed. Early fluoroquinolone (FQ) use was defined as receiving ≥5 doses during the first month of treatment...
August 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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