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https://www.readbyqxmd.com/read/27911851/inherited-variants-affecting-rna-editing-may-contribute-to-ovarian-cancer-susceptibility-results-from-a-large-scale-collaboration
#1
Jennifer B Permuth, Brett Reid, Madalene Earp, Y Ann Chen, Alvaro N A Monteiro, Zhihua Chen, Aocs Study Group, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Adriaan Vanderstichele, Els Van Niewenhuyse, Ignace Vergote, Mary Anne Rossing, Jennifer Anne Doherty, Jenny Chang-Claude, Kirsten Moysich, Kunle Odunsi, Marc T Goodman, Yurii B Shvetsov, Lynne R Wilkens, Pamela J Thompson, Thilo Dörk, Natalia Bogdanova, Ralf Butzow, Heli Nevanlinna, Liisa Pelttari, Arto Leminen, Francesmary Modugno, Robert P Edwards, Roberta B Ness, Joseph Kelley, Florian Heitz, Beth Karlan, Jenny Lester, Susanne K Kjaer, Allan Jensen, Graham Giles, Michelle Hildebrandt, Dong Liang, Karen H Lu, Xifeng Wu, Douglas A Levine, Maria Bisogna, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Shelley S Tworoger, Elizabeth M Poole, Elisa V Bandera, Brooke Fridley, Julie Cunningham, Stacey J Winham, Sara H Olson, Irene Orlow, Line Bjorge, Lambertus A Kiemeney, Leon Massuger, Tanja Pejovic, Melissa Moffitt, Nhu Le, Linda S Cook, Angela Brooks-Wilson, Linda E Kelemen, Jacek Gronwald, Jan Lubinski, Nicolas Wentzensen, Louise A Brinton, Jolanta Lissowska, Hanna Yang, Estrid Hogdall, Claus Hogdall, Lene Lundvall, Paul D P Pharoah, Honglin Song, Ian Campbell, Diana Eccles, Iain McNeish, Alice Whittemore, Valerie McGuire, Weiva Sieh, Joseph Rothstein, Catherine M Phelan, Harvey Risch, Steven Narod, John McLaughlin, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Celeste Leigh Pearce, Anna H Wu, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Joellen M Schildkraut, Jin Q Cheng, Ellen L Goode, Thomas A Sellers
RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypothesized that single nucleotide polymorphisms (SNPs) in ADAR genes modify EOC susceptibility, potentially by altering ovarian tissue gene expression. Using directly genotyped and imputed data from 10,891 invasive EOC cases and 21,693 controls, we evaluated the associations of 5,303 SNPs in ADAD1, ADAR, ADAR2, ADAR3, and SND1...
July 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27911589/recommended-reading-from-university-of-georgia-department-of-epidemiology-and-biostatistics-fellows
#2
Leonardo Martinez, María Eugenia Castellanos, Benjamin D Hallowell, Christopher C Whalen
No abstract text is available yet for this article.
December 2, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27909759/continuous-hydrostatic-pressure-induces-differentiation-phenomena-in-chondrocytes-mediated-by-changes-in-polycystins-sox9-and-runx2
#3
Konstantinos Karamesinis, Anastasia Spyropoulou, Georgia Dalagiorgou, Maria A Katsianou, Marjan Nokhbehsaim, Svenja Memmert, James Deschner, Heleni Vastardis, Christina Piperi
PURPOSE: The present study aimed to investigate the long-term effects of hydrostatic pressure on chondrocyte differentiation, as indicated by protein levels of transcription factors SOX9 and RUNX2, on transcriptional activity of SOX9, as determined by pSOX9 levels, and on the expression of polycystin-encoding genes Pkd1 and Pkd2. MATERIALS AND METHODS: ATDC5 cells were cultured in insulin-supplemented differentiation medium (ITS) and/or exposed to 14.7 kPa of hydrostatic pressure for 12, 24, 48, and 96 h...
December 1, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27908515/intraoperative-enteroscopy-is-there-still-a-role
#4
REVIEW
Thibault Voron, Gabriel Rahmi, Stephane Bonnet, Georgia Malamut, Philippe Wind, Christophe Cellier, Anne Berger, Richard Douard
Intraoperative enteroscopy (IOE) to explore obscure gastrointestinal bleeding is now rarely indicated. IOE allows complete small bowel exploration in 57% to 100% of cases, finds a bleeding source in 80% of cases, allows the recurrence-free management of gastrointestinal bleeding in 76% of cases, but carries a high morbidity and mortality. IOE only remains indicated to guide the intraoperative treatment of preoperatively identified small bowel lesions when nonoperative treatments are unavailable and/or when intraoperative localization by external examination is impossible...
January 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/27908038/phonetic-imitation-of-coarticulatory-vowel-nasalization
#5
Georgia Zellou, Rebecca Scarborough, Kuniko Nielsen
This study investigates the spontaneous phonetic imitation of coarticulatory vowel nasalization. Speakers produced monosyllabic words with a vowel-nasal sequence either from dense or sparse phonological neighborhoods in shadowing and word-naming tasks. During shadowing, they were exposed to target words that were modified to have either an artificially increased or decreased degree of coarticulatory vowel nasality. Increased nasality, which is communicatively more facilitative in that it provides robust predictive information about the upcoming nasal segment, was imitated more strongly during shadowing than decreased nasality...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27905944/methods-of-applying-the-1994-case-definition-of-chronic-fatigue-syndrome-impact-on-classification-and-observed-illness-characteristics
#6
E R Unger, J-M S Lin, H Tian, B M Gurbaxani, R S Boneva, J F Jones
BACKGROUND: Multiple case definitions are in use to identify chronic fatigue syndrome (CFS). Even when using the same definition, methods used to apply definitional criteria may affect results. The Centers for Disease Control and Prevention (CDC) conducted two population-based studies estimating CFS prevalence using the 1994 case definition; one relied on direct questions for criteria of fatigue, functional impairment and symptoms (1997 Wichita; Method 1), and the other used subscale score thresholds of standardized questionnaires for criteria (2004 Georgia; Method 2)...
March 12, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905191/race-and-ethnicity-and-preconception-folic-acid-supplement-use-among-pregnant-women-in-georgia-prams-2009-to-2011
#7
Ayesha Mukhtar, Michael R Kramer, Godfrey P Oakley, Vijaya Kancherla
BACKGROUND: The United States Public Health Service recommends that all women of reproductive age consume 400 μg of folic acid daily to prevent major neural tube defects. Hispanics have the highest prevalence of neural tube defects compared with other race/ethnic groups. We studied prevalence of preconception folic acid supplement use, and its association with race/ethnicity among pregnant women in Georgia. METHODS: Using state-wide population-based data from 2009 to 2011 Georgia Pregnancy Risk Assessment Monitoring System, we examined the prevalence of preconception folic acid supplement use among pregnant women aged 18 to 45 years...
December 1, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27905183/mini-c-arm-faster-cheaper-safer
#8
Tom J Gieroba, Nicole Williams, Georgia Antoniou, Peter J Cundy
BACKGROUND: Mini C-arm image intensifiers (IIs) are promoted to permit lower radiation dose than traditional IIs with a lower purchase price and without the need for a radiographer, saving time. In real-world usage, radiation dose is not always lower. METHODS: A retrospective review of prospectively collected data for 620 children undergoing forearm fracture reduction in theatre was undertaken. Imaging was performed with the Fluoroscan mini C-arm or a comparison traditional II...
November 30, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27902826/association-of-a-frailty-screening-initiative-with-postoperative-survival-at-30-180-and-365-days
#9
Daniel E Hall, Shipra Arya, Kendra K Schmid, Mark A Carlson, Pierre Lavedan, Travis L Bailey, Georgia Purviance, Tammy Bockman, Thomas G Lynch, Jason M Johanning
Importance: As the US population ages, the number of operations performed on elderly patients will likely increase. Frailty predicts postoperative mortality and morbidity more than age alone, thus presenting opportunities to identify the highest-risk surgical patients and improve their outcomes. Objective: To examine the effect of the Frailty Screening Initiative (FSI) on mortality and complications by comparing the surgical outcomes of a cohort of surgical patients treated before and after implementation of the FSI...
November 30, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27901622/childhood-asthma-in-batumi-georgia-prevalence-correlates-potential-underdiagnosis
#10
Vakhtang Beridze, Lia Abuladze, Naira Partenadze, Tamar Bakhtadze, Joshua Lawson, Jan E Zejda
OBJECTIVE: A relative lack of data for Eastern Europe and unknown epidemiology of childhood asthma in Batumi (Georgia) justified a study aimed at determining the prevalence of physician-diagnosed asthma and related respiratory conditions, a comparison of the prevalence of these conditions between urban and rural children, and identification of their environmental correlates. METHODS: Subjects of the cross-sectional population-based study were 3238 urban and 2081 rural children aged 5-17 years whose respiratory status was assessed using the ISAAC questionnaire...
November 30, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27900621/an-assessment-of-radiation-oncology-medical-physicists-perspectives-on-undertaking-research
#11
Martin A Ebert, Georgia K B Halkett, Melissa Berg, David Cutt, Michael Davis, Desley Hegney, Michael House, Michele Krawiec, Rachel Kearvell, Leanne Lester, Sharon Maresse, Peter McLoone, Jan McKay
As part of a study of the radiation oncology workforce, radiation oncology medical physicists (ROMPs) who had worked in Australia were surveyed regarding their attitudes to participating in research. Responses from 88 ROMPs were available for analysis, representing a broad mix of employment situations and research experience. Greater than 70% of ROMPs described their involvement in research as "liking it" or "loving it", with associated identified benefits including skills development, job satisfaction and career progression...
November 29, 2016: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/27900588/modeling-informatics-at-vertex-pharmaceuticals-incorporated-our-philosophy-for-sustained-impact
#12
Georgia McGaughey, W Patrick Walters
Molecular modelers and informaticians have the unique opportunity to integrate cross-functional data using a myriad of tools, methods and visuals to generate information. Using their drug discovery expertise, information is transformed to knowledge that impacts drug discovery. These insights are often times formulated locally and then applied more broadly, which influence the discovery of new medicines. This is particularly true in an organization where the members are exposed to projects throughout an organization, such as in the case of the global Modeling & Informatics group at Vertex Pharmaceuticals...
November 29, 2016: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/27898828/population-structure-in-the-model-grass-is-highly-correlated-with-flowering-differences-across-broad-geographic-areas
#13
Ludmila Tyler, Scott J Lee, Nelson D Young, Gregory A DeIulio, Elena Benavente, Michael Reagon, Jessica Sysopha, Riccardo M Baldini, Angelo Troìa, Samuel P Hazen, Ana L Caicedo
The small, annual grass (L.) Beauv., a close relative of wheat ( L.) and barley ( L.), is a powerful model system for cereals and bioenergy grasses. Genome-wide association studies (GWAS) of natural variation can elucidate the genetic basis of complex traits but have been so far limited in by the lack of large numbers of well-characterized and sufficiently diverse accessions. Here, we report on genotyping-by-sequencing (GBS) of 84 , seven , and three accessions with diverse geographic origins including Albania, Armenia, Georgia, Italy, Spain, and Turkey...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27898335/genetically-edited-pigs-lacking-cd163-show-no-resistance-following-infection-with-the-african-swine-fever-virus-isolate-georgia-2007-1
#14
Luca Popescu, Natasha N Gaudreault, Kristen M Whitworth, Maria V Murgia, Jerome C Nietfeld, Alan Mileham, Melissa Samuel, Kevin D Wells, Randall S Prather, Raymond R R Rowland
African swine fever is a highly contagious, often fatal disease of swine for which there is no vaccine or other curative treatment. The macrophage marker, CD163, is a putative receptor for African swine fever virus (ASFV). Pigs possessing a complete knockout of CD163 on macrophages were inoculated with Georgia 2007/1, a genotype 2 isolate. Knockout and wild type pen mates became infected and showed no differences in clinical signs, mortality, pathology or viremia. There was also no difference following in vitro infection of macrophages...
November 26, 2016: Virology
https://www.readbyqxmd.com/read/27896027/assessing-pollinators-use-of-floral-resource-subsidies-in-agri-environment-schemes-an-illustration-using-phacelia-tanacetifolia-and-honeybees
#15
Rowan Sprague, Stéphane Boyer, Georgia M Stevenson, Steve D Wratten
BACKGROUND: Honeybees (Apis mellifera L.) are frequently used in agriculture for pollination services because of their abundance, generalist floral preferences, ease of management and hive transport. However, their populations are declining in many countries. Agri-Environment Schemes (AES) are being implemented in agricultural systems to combat the decline in populations of pollinators and other insects. Despite AES being increasingly embedded in policy and budgets, scientific assessments of many of these schemes still are lacking, and only a few studies have examined the extent to which insect pollinators use the floral enhancements that are part of AES and on which floral components they feed (i...
2016: PeerJ
https://www.readbyqxmd.com/read/27895815/molecular-predictive-markers-in-tumors-of-the-gastrointestinal-tract
#16
REVIEW
Eirini Papadopoulou, Vasiliki Metaxa-Mariatou, Georgios Tsaousis, Nikolaos Tsoulos, Angeliki Tsirigoti, Chrisoula Efstathiadou, Angela Apessos, Konstantinos Agiannitopoulos, Georgia Pepe, Eugenia Bourkoula, George Nasioulas
Gastrointestinal malignancies are among the leading causes of cancer-related deaths worldwide. Like all human malignancies they are characterized by accumulation of mutations which lead to inactivation of tumor suppressor genes or activation of oncogenes. Advances in Molecular Biology techniques have allowed for more accurate analysis of tumors' genetic profiling using new breakthrough technologies such as next generation sequencing (NGS), leading to the development of targeted therapeutical approaches based upon biomarker-selection...
November 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27893030/development-and-initial-validation-of-the-risk-analysis-index-for-measuring-frailty-in-surgical-populations
#17
Daniel E Hall, Shipra Arya, Kendra K Schmid, Casey Blaser, Mark A Carlson, Travis L Bailey, Georgia Purviance, Tammy Bockman, Thomas G Lynch, Jason Johanning
Importance: Growing consensus suggests that frailty-associated risks should inform shared surgical decision making. However, it is not clear how best to screen for frailty in preoperative surgical populations. Objective: To develop and validate the Risk Analysis Index (RAI), a 14-item instrument used to measure surgical frailty. It can be calculated prospectively (RAI-C), using a clinical questionnaire, or retrospectively (RAI-A), using variables from the surgical quality improvement databases (Veterans Affairs or American College of Surgeons National Surgical Quality Improvement Projects)...
November 23, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27891291/knowledge-about-hiv-in-a-community-sample-of-urban-african-americans-in-the-south
#18
H Klein, C E Sterk, K W Elifson
PURPOSE: Race and HIV are intertwined in complex ways. African Americans, particularly those residing in the southern United States, are at great risk for contracting and subsequently transmitting HIV. Research on the extent to which members of this population understand the risks associated with engaging in specific behaviors is limited. This paper examines HIV knowledge among at-risk adult African American men and women and the factors associated with levels of HIV knowledge. METHODS: Based on a conceptual model derived from Social Disorganization Theory and Syndemics Theory, interviews were conducted between 2009 and 2011...
October 2016: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/27891228/a-probabilistic-algorithm-to-process-geolocation-data
#19
Benjamin Merkel, Richard A Phillips, Sébastien Descamps, Nigel G Yoccoz, Børge Moe, Hallvard Strøm
BACKGROUND: The use of light level loggers (geolocators) to understand movements and distributions in terrestrial and marine vertebrates, particularly during the non-breeding period, has increased dramatically in recent years. However, inferring positions from light data is not straightforward, often relies on assumptions that are difficult to test, or includes an element of subjectivity. RESULTS: We present an intuitive framework to compute locations from twilight events collected by geolocators from different manufacturers...
2016: Movement Ecology
https://www.readbyqxmd.com/read/27891143/comparative-physiological-and-proteomic-analysis-reveal-distinct-regulation-of-peach-skin-quality-traits-by-altitude
#20
Evangelos Karagiannis, Georgia Tanou, Martina Samiotaki, Michail Michailidis, Grigorios Diamantidis, Ioannis S Minas, Athanassios Molassiotis
The role of environment in fruit physiology has been established; however, knowledge regarding the effect of altitude in fruit quality traits is still lacking. Here, skin tissue quality characters were analyzed in peach fruit (cv. June Gold), harvested in 16 orchards located in low (71.5 m mean), or high (495 m mean) altitutes sites. Data indicated that soluble solids concentration and fruit firmness at commercial harvest stage were unaffected by alitute. Peach grown at high-altitude environment displayed higher levels of pigmentation and specific antioxidant-related activity in their skin at the commercial harvest stage...
2016: Frontiers in Plant Science
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