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https://www.readbyqxmd.com/read/29220633/developing-adaptive-treatment-strategies-to-address-suicidal-risk-in-college-students-a-pilot-sequential-multiple-assignment-randomized-trial-smart
#1
Jacqueline Pistorello, David Jobes, Scott Compton, Nadia Samad Locey, Joseph C Walloch, Robert Gallop, Josephine S Au, Samantha K Noose, Maria Young, Jacquelyn Johnson, Yani Dickens, Patricia Chatham, Tami Jeffcoat, Georgia Dalto, Spondita Goswami
OBJECTIVES: This pilot study investigated the potential to utilize adaptive treatment strategies for treating moderate to severe suicidal risk among college students. This paper will describe the unique design and report on feasibility and acceptability findings. METHODS: A two-stage Sequential Multiple Assignment Randomized Trial (SMART) was conducted: In Stage 1, 62 suicidal college students were randomized to either a suicide-focused or a treatment-as-usual condition (4-8 weeks)...
December 8, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/29217468/availability-of-hepatitis-c-diagnostics-and-therapeutics-in-european-and-eurasia-countries
#2
Hakan Leblebicioglu, Joop E Arends, Resat Ozaras, Giampaolo Corti, Lurdes Santos, Christoph Boesecke, Andrew Ustianowski, Ann-Sofi Duberg, Simona Ruta, Nermin N Salkic, Petr Husa, Ivana Lazarevic, Juan A Pineda, Natalia Yurievna Pshenichnaya, Tengiz Tsertswadze, Mojca Matičič, Edmond Puca, Gulzhan Abuova, Judit Gervain, Ramin Bayramli, Salih Ahmeti, Mairi Koulentaki, Badreddine Kilani, Adriana Vince, Francesco Negro, Mustafa Sunbul, Dominique Salmon
BACKGROUND: Treatment with direct acting antiviral agents (DAAs) has provided sustained virological response rates in >95% of patients with chronic hepatitis C virus (HCV) infection. However treatment is costly and market access, reimbursement and governmental restrictions differ among countries. We aimed to analyze these differences among European and Eurasian countries. METHODS: A survey including 20-item questionnaire was sent to experts in viral hepatitis...
December 4, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29216901/genomic-variants-in-the-fto-gene-are-associated-with-sporadic-amyotrophic-lateral-sclerosis-in-greek-patients
#3
Konstantinos Mitropoulos, Eleni Merkouri Papadima, Georgia Xiromerisiou, Angeliki Balasopoulou, Kyriaki Charalampidou, Vasiliki Galani, Krystallia-Vassiliki Zafeiri, Efthymios Dardiotis, Styliani Ralli, Georgia Deretzi, Anne John, Kyriaki Kydonopoulou, Elpida Papadopoulou, Alba di Pardo, Fulya Akcimen, Annalisa Loizedda, Valerija Dobričić, Ivana Novaković, Vladimir S Kostić, Clint Mizzi, Brock A Peters, Nazli Basak, Sandro Orrù, Evangelos Kiskinis, David N Cooper, Spyridon Gerou, Radoje Drmanac, Marina Bartsakoulia, Evangelia-Eirini Tsermpini, Georgios M Hadjigeorgiou, Bassam R Ali, Theodora Katsila, George P Patrinos
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating disease whose complex pathology has been associated with a strong genetic component in the context of both familial and sporadic disease. Herein, we adopted a next-generation sequencing approach to Greek patients suffering from sporadic ALS (together with their healthy counterparts) in order to explore further the genetic basis of sporadic ALS (sALS). RESULTS: Whole-genome sequencing analysis of Greek sALS patients revealed a positive association between FTO and TBC1D1 gene variants and sALS...
December 8, 2017: Human Genomics
https://www.readbyqxmd.com/read/29216739/lymphatic-drainage-efficiency-a-new-parameter-of-lymphatic-function
#4
Georgia Keramida, Emma Wroe, Nicola Winterman, Mark Aplin, A Michael Peters
Background Following convection from blood capillaries, plasma proteins are transported to loco-regional lymph nodes in two stages: first, uptake into peripheral lymphatics, and second, transport to nodes. Purpose To introduce a new parameter of lymphatic function that quantifies stage 2 - lymphatic drainage efficiency (LDE). Material and Methods Percentage injected activity (IIQ) in ilio-inguinal nodes 150 min following subcutaneous foot web-space injection of Tc-99 m-nanocolloid was measured in 102 patients undergoing lymphoscintigraphy using a method in which a standard is placed by image guidance over the nodes...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29216592/activated-carbon-thin-layer-placement-as-an-in-situ-mercury-remediation-tool-in-a-penobscot-river-salt-marsh
#5
Cynthia Gilmour, Tyler Bell, Ally Soren, Georgia Riedel, Gerhardt Riedel, Dianne Kopec, Drew Bodaly, Upal Ghosh
The efficacy of thin layer in situ soil amendments was tested as a potential tool for methylmercury (MeHg) risk mitigation in Penobscot River, ME, salt marsh. Salt marshes are sites of high MeHg accumulation within the Penobscot, and key targets for remediation. The study was a fully-crossed small plot study, with four treatments (activated carbon (AC), biochar, FeCl2, and lime) and unamended controls at two sites. Plots were monitored for two years. Porewater MeHg concentrations were the main endpoint, with impacts on sediment biogeochemistry as a secondary study goal...
December 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29215087/mitochondrial-dna-variations-in-austronesian-speaking-populations-living-in-the-new-georgia-islands-the-western-province-of-the-solomon-islands
#6
Mariko Issiki, Izumi Naka, Ryosuke Kimura, Takuro Furusawa, Kazumi Natsuhara, Taro Yamauchi, Minato Nakazawa, Takafumi Ishida, Ryutaro Ohtsuka, Jun Ohashi
Modern Austronesian (AN)-speaking Melanesians are considered to be derived from the admixture of indigenous non-Austronesian (NAN)-speaking people and AN-speaking people from Southeast Asia. In this study, we analyzed mitochondrial DNA (mtDNA) variations in the D-loop region for two AN-speaking Melanesian populations (Munda and Kusaghe) and an AN-speaking Micronesian population (Rawaki) in the New Georgia Islands, the Western Province of the Solomon Islands to examine their genetic similarities to AN-speaking Polynesians in Tonga and NAN-speaking Melanesians, Gidra, in Papua New Guinea...
November 13, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29214980/ion-chambers-compliance-results-of-brazilian-radiation-therapy-facilities
#7
Georgia Santos Joana, Camila Salata, Paulo Leal, Renato Oliveira, Nozimar do Couto, Flavia Cristina Teixeira, Abner Duarte Soares, Eduardo Sergio Santini, Marcello Gomes Gonçalves
Brazilian Nuclear Energy Commission (cnen) has been making a constant effort to keep updated with international standards and national needs to strengthen the status of radiological protection of the country. The guidelines related to radiation therapy facilities have been revised in the last five years in order to take in consideration the most relevant aspects of the growing technology as well as to mitigate the accidents or incidents observed in practice. Hence, clinical dosimeters have gained special importance in this matter...
December 7, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29213355/draft-genome-sequence-of-venturia-carpophila-the-causal-agent-of-peach-scab
#8
Chunxian Chen, Clive H Bock, Bruce W Wood
Venturia carpophila causes peach scab, a disease that renders peach (Prunus persica) fruit unmarketable. We report a high-quality draft genome sequence (36.9 Mb) of V. carpophila from an isolate collected from a peach tree in central Georgia in the United States. The genome annotation is described and a phylogenetic analysis of the pathogen is presented. The genome sequence will be a useful resource for various studies on the pathogen, including the biology and ecology, taxonomy and phylogeny, host interaction and coevolution, isolation and characterization of genes of interest, and development of molecular markers for genotyping and mapping...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29213030/acute-bilateral-ophthalmoplegia-due-to-vertebrobasilar-dolichoectasia-a-report-of-two-cases
#9
Haifa Alabri, Whitfield D Lewis, Sunil Manjila, Ayham M Alkhachroum, Michael A De Georgia
BACKGROUND Vertebrobasilar dolichoectasia (VBD) is a complex progressive arterial disease characterized by dilation, elongation, and tortuosity of the vertebral and basilar arteries, and may be congenital or acquired. VBD may lead to progressive compression of the brainstem, cranial nerve abnormalities, and intracranial hemorrhage, but may also be associated with arterial thrombosis, with ischemic stroke as the most common clinical outcome. CASE REPORT Two cases of VBD are presented, both with acute bilateral ophthalmoplegia and cranial nerve palsies, and vertebrobasilar arterial thrombosis that resulted in ischemic stroke...
December 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29212866/acquired-haemophilia-a-complicating-alemtuzumab-therapy-for-multiple-sclerosis
#10
Georgia McCaughan, Jennifer Massey, Ian Sutton, Jennifer Curnow
Alemtuzumab is a highly efficacious therapy used in the treatment of multiple sclerosis (MS), but uncoupling of T and B cell repopulation during immune reconstitution associates with an increasing range of secondary B cell-mediated autoimmune complications. A 34-year-old woman developed Graves' disease 11 months following an initial course of alemtuzumab treatment for MS. Nine months following the second treatment with alemtuzumab, the patient presented with spontaneous intramuscular and subcutaneous haemorrhage due to development of an inhibitory autoantibody to coagulation factor VIII...
December 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29211771/short-term-succinic-acid-treatment-mitigates-cerebellar-mitochondrial-oxphos-dysfunction-neurodegeneration-and-ataxia-in-a-purkinje-specific-spinocerebellar-ataxia-type-1-sca1-mouse-model
#11
Austin Ferro, Emily Carbone, Jenny Zhang, Evan Marzouk, Monica Villegas, Asher Siegel, Donna Nguyen, Thomas Possidente, Jessilyn Hartman, Kailen Polley, Melissa A Ingram, Georgia Berry, Thomas H Reynolds, Bernard Possidente, Kimberley Frederick, Stephen Ives, Sarita Lagalwar
Mitochondrial dysfunction plays a significant role in neurodegenerative disease including ataxias and other movement disorders, particularly those marked by progressive degeneration in the cerebellum. In this study, we investigate the role of mitochondrial oxidative phosphorylation (OXPHOS) deficits in cerebellar tissue of a Purkinje cell-driven spinocerebellar ataxia type 1 (SCA1) mouse. Using RNA sequencing transcriptomics, OXPHOS complex assembly analysis and oxygen consumption assays, we report that in the presence of mutant polyglutamine-expanded ataxin-1, SCA1 mice display deficits in cerebellar OXPHOS complex I (NADH-coenzyme Q oxidoreductase)...
2017: PloS One
https://www.readbyqxmd.com/read/29211266/interventions-to-promote-physical-activity-for-adults-with-intellectual-disabilities
#12
Viviene A Temple, Georgia C Frey, Heidi I Stanish
OBJECTIVE: To describe interventions designed to promote physical activity for adults with intellectual disabilities and the effects on overall physical activity levels and on health outcomes. MATERIALS AND METHODS: A systematic review of eight databases until January 31, 2015 identified 383 citations. The inclusion criteria were: a) the study sample consisted of adults with intellectual disabilities, b) the study implemented an intervention to initiate, increase, or maintain physical activity, and c) quantitative or qualitative data were used to report the effectiveness of the intervention...
July 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29211265/interventions-to-promote-physical-activity-for-youth-with-intellectual-disabilities
#13
Georgia C Frey, Viviene A Temple, Heidi I Stanish
OBJECTIVE: To describe interventions designed to promote physical activity for youth with intellectual disabilities. MATERIALS AND METHODS: A systematic review of nine databases until January 31, 2015 identified 213 citations. The inclusion criteria were: a) the study sample consisted of youth with intellectual disabilities, b) the study implemented an intervention to initiate, increase, or maintain physical activity, and c) quantitative or qualitative data were used to report the effectiveness of the intervention...
July 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29210968/what-s-y-our-brand
#14
Georgia Elmassian
No abstract text is available yet for this article.
October 2017: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/29209427/how-to-give-and-receive-%C3%A2-feedback-effectively
#15
Georgia Hardavella, Ane Aamli-Gaagnat, Neil Saad, Ilona Rousalova, Katherina B Sreter
Giving and receiving effective feedback are skills that are central in healthcare settings http://ow.ly/zZ1C30eVrH1.
December 2017: Breathe
https://www.readbyqxmd.com/read/29209422/the-potential-of-palliative-care-for-patients-with-respiratory-diseases
#16
Georgia L Narsavage, Yea-Jyh Chen, Bettina Korn, Ronit Elk
Based on the demonstrated effectiveness of palliative care in the alleviation of symptoms and enhancement of life quality, it is important to incorporate palliative care early in the respiratory disease trajectory. Quality palliative care addresses eight domains that are all patient and family centred. Palliative care interventions in respiratory conditions include management of symptoms such as dyspnoea, cough, haemoptysis, sputum production, fatigue and respiratory secretion management, especially as the end-of-life nears...
December 2017: Breathe
https://www.readbyqxmd.com/read/29207404/cognitive-development-in-pediatric-epilepsy-surgery
#17
Georgia Ramantani, Gitta Reuner
No abstract text is available yet for this article.
December 5, 2017: Neuropediatrics
https://www.readbyqxmd.com/read/29205929/dendritic-cell-targeted-hiv-1-gag-protein-vaccine-provides-help-to-a-recombinant-newcastle-disease-virus-vectored-vaccine-including-mobilization-of-protective-cd8-t-cells
#18
Loveline N Ngu, Nadesh N Nji, Georgia Ambada, Apeh A Ngoh, Ghislain D Njambe Priso, Jules C Tchadji, Abel Lissom, Suzanne H Magagoum, Carol N Sake, Thibau F Tchouangueu, George O Chukwuma, Arinze S Okoli, Bertrand Sagnia, Rebecca Chukwuanukwu, Denis M Tebit, Charles O Esimone, Alain B Waffo, Chae G Park, Klaus Überla, Godwin W Nchinda
INTRODUCTION: Recombinant Newcastle Disease virus (rNDV) vectored vaccines are safe mucosal applicable vaccines with intrinsic immune-modulatory properties for the induction of efficient immunity. Like all viral vectored vaccines repeated inoculation via mucosal routes invariably results to immunity against viral vaccine vectors. To obviate immunity against viral vaccine vectors and improve the ability of rNDV vectored vaccines in inducing T cell immunity in murine air way we have directed dendritic cell targeted HIV-1 gag protein (DEC-Gag) vaccine; for the induction of helper CD4+ T cells to a Recombinant Newcastle disease virus expressing codon optimized HIV-1 Gag P55 (rNDV-L-Gag) vaccine...
December 4, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29204806/promotion-of-healthy-humor-cancer-education-messages-for-the-deaf-community
#19
Moshe Engelberg, Melanie C Nakaji, Kadie M Harry, Regina M Wang, Adrienne Kennedy, Tonya M Pan, Teresa Sanchez, Georgia Robins Sadler
The Deaf community members of this community-campus partnership identified the lack of health information in American Sign Language (ASL) as a significant barrier to increasing the Deaf community's health knowledge. Studies have shown that the delivery of health messages in ASL increased Deaf study participants' cancer knowledge. Once health messages are available on the Internet, strategies are needed to attract viewers to the website and to make repeat visits in order to promote widespread knowledge gains...
December 4, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29204159/what-pelvic-radiation-disease-symptoms-are-experienced-by-patients-receiving-external-beam-radiotherapy-and-a-high-dose-rate-brachytherapy-boost-for-prostate-cancer
#20
Georgia K B Halkett, Michala Short, Samar Aoun, David Joseph, Sean Bydder, Xingqiong Meng, Nigel Spry
Purpose: Research describing proctitis or pelvic radiation disease symptoms of prostate cancer patients one year after external beam radiotherapy (EBRT) plus high-dose-rate (HDR) brachytherapy is limited. This study aimed to assess prostate cancer patients' pelvic radiation disease symptoms from baseline to 12 months post-radiotherapy. Material and methods: Men with prostate cancer referred for EBRT and HDR brachytherapy were recruited. Patients' age, diagnosis, staging, PSA, past medical history, and treatment were recorded...
October 2017: Journal of Contemporary Brachytherapy
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