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Richard Peffer, Matthew LeBaron, Michael Battalora, Werner Bomann, Christoph Werner, Manoj Aggarwal, Rocky Rowe, Helen Tinwell
Methods for investigating the Mode of Action (MoA) for rodent liver tumors via constitutive androstane receptor (CAR) activation are outlined here, based on current scientific knowledge about CAR and feedback from regulatory agencies globally. The key events (i.e., CAR activation, altered gene expression, cell proliferation, altered foci and increased adenomas/carcinomas) can be demonstrated by measuring a combination of key events and associative events that are markers for the key events. For crop protection products, a primary dataset typically should include a short-term study in the species/strain that showed the tumor response at dose levels that bracket the tumorigenic and non-tumorigenic dose levels...
April 16, 2018: Regulatory Toxicology and Pharmacology: RTP
Falko Schmidt, Fatih Kilic, Neltje Emma Piro, Martin Eberhard Geiger, Bernd Georg Lapatki
Quantitative three-dimensional analysis of orthodontic tooth movement (OTM) is possible by superposition of digital jaw models made at different times during treatment. Conventional methods rely on surface alignment at palatal soft-tissue areas, which is applicable to the maxilla only. We introduce two novel numerical methods applicable to both maxilla and mandible. The OTM from the initial phase of multi-bracket appliance treatment of ten pairs of maxillary models were evaluated and compared with four conventional methods...
April 18, 2018: Annals of Biomedical Engineering
Tejas R Pol, Meghna Vandekar, Anuradha Patil, Sanjana Desai, Vikram Shetty, Saptarshi Hazarika
Background: The aim of present study was to investigate the difference of torque control during intrusive force on upper central incisors with normal, under and high torque in lingual and labial orthodontic systems through 3D finite element analysis. Material and Methods: Six 3D models of an upper right central incisor with different torque were designed in Solid Works 2006. Software ANSYS Version 16.0 was used to evaluate intrusive force on upper central incisor model ...
January 2018: Journal of Clinical and Experimental Dentistry
Tengxiao Ma, Feng Xie, Zhengwen Zhang
BACKGROUND: Auricular reconstruction is one of the most challenging procedures in the field of plastic surgery. The aims of this study were to apply the modified 2-stage method to perform auricular reconstruction and to summarize the clinical experience in the past 10 years. METHODS: Auricular reconstruction was performed in 243 patients (total 254 ears) of congenital microtia using autologous costal cartilage. The whole procedure is divided into 2 stages. Stage I: the individualized framework fabricated with autologous costal cartilage is inserted into subcutaneous pocket in the mastoid region, and then the earlobe was transposed backward to connect with the lower part of the framework...
April 17, 2018: Annals of Plastic Surgery
Richard E Campbell, Heather T Morris, Kyle T Reynolds, Elizabeth S Gosnell
A 13-year-old female presented with traumatized maxillary central incisors that had been endodontically treated. Five years later, at a different dental office, she had the clinical crowns removed, leaving subgingival margins. From the patient's history and our initial assessment, it seemed as if the teeth had been fractured and luxated but not avulsed. Endodontic posts with spot-welded orthodontic brackets were temporarily cemented to enable orthodontic extrusion. Once access to restorable margins was obtained, the temporary posts were removed and conventional fiber posts with interim composite crowns were placed...
January 15, 2018: Journal of Dentistry for Children
Florian Kaiser, Sebastian Bittrich, Sebastian Salentin, Christoph Leberecht, V Joachim Haupt, Sarah Krautwurst, Michael Schroeder, Dirk Labudde
The origin of the machinery that realizes protein biosynthesis in all organisms is still unclear. One key component of this machinery are aminoacyl tRNA synthetases (aaRS), which ligate tRNAs to amino acids while consuming ATP. Sequence analyses revealed that these enzymes can be divided into two complementary classes. Both classes differ significantly on a sequence and structural level, feature different reaction mechanisms, and occur in diverse oligomerization states. The one unifying aspect of both classes is their function of binding ATP...
April 16, 2018: PLoS Computational Biology
Isil Aras, Idil Unal, Gencer Huniler, Aynur Aras
OBJECTIVES: Purpose of the present study was to compare external root resorption (ERR) volumetrically in maxillary incisors induced by orthodontic treatment using self-ligating brackets (Damon Q, DQ) or conventional brackets (Titanium Orthos, TO) with the help of cone-beam computed tomography (CBCT). PATIENTS AND METHODS: A sample of 32 subjects, with Angle Class I malocclusion and anterior crowding of 4-10 mm, was divided randomly into two groups: a DQ group, in which self-ligating DQ brackets with Damon archwires were used; and a TO group, in which conventional TO brackets with large Orthos archwires were applied...
April 12, 2018: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Justin Shumate, Pierre Baillargeon, Timothy P Spicer, Louis Scampavia
Critical to maintaining quality control in high-throughput screening is the need for constant monitoring of liquid-dispensing fidelity. Traditional methods involve operator intervention with gravimetric analysis to monitor the gross accuracy of full plate dispenses, visual verification of contents, or dedicated weigh stations on screening platforms that introduce potential bottlenecks and increase the plate-processing cycle time. We present a unique solution using open-source hardware, software, and 3D printing to automate dispenser accuracy determination by providing real-time dispense weight measurements via a network-connected precision balance...
April 1, 2018: SLAS Technology
Saara Mikkonen, Wolfgang Thormann
Computer simulation was utilized to characterize the electrophoretic processes occurring after reactant mixing in an on-line assay format used for monitoring the enantioselective N-demethylation of ketamine to norketamine in presence of highly sulfated γ-cyclodextrin (HS-γ-CD). The incubated reaction mixture (at pH 7.4 and without chiral selector) is bracketed by a low pH BGE containing 2 % HS-γ-CD as chiral selector, thereby forming a discontinuous buffer system. Upon power application, simulation provides insight into the formation of moving boundaries and new zones together with the prediction of the behavior of ketamine and norketamine enantiomers...
April 12, 2018: Electrophoresis
Iury Oliveira Castro, Bruno Frazão Gribel, Ana Helena Gonçalves de Alencar, José Valladares-Neto, Carlos Estrela
PURPOSE: To compare crown inclination and angulation results obtained after orthodontic treatment to the Roth prescription. METHODS: The study design was based on files and documents obtained from a database of 26 patients who had undergone orthodontic treatment using the straight-wire technique and the Roth prescription. The crown inclination and angulation were measured using a three-dimensional (3D) cephalometric module (VistaDent, Dentsply, New York, NY, USA) by an orthodontist...
April 11, 2018: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Nicky A Mandall, Joy Hickman, Tatiana V Macfarlane, Rye Cr Mattick, Declan T Millett, Helen V Worthington
BACKGROUND: Bonding of orthodontic brackets to teeth is important to enable effective and efficient treatment with fixed appliances. The problem is bracket failure during treatment which increases operator chairside time and lengthens treatment time. A prolonged treatment is likely to increase the oral health risks of orthodontic treatment with fixed appliances one of which is irreversible enamel decalcification. This is an update of the Cochrane Review first published in 2003. A new full search was conducted on 26 September 2017 but no new studies were identified...
April 9, 2018: Cochrane Database of Systematic Reviews
Altaf Hussian Thekiya, K R Aileni, Madhukar Reddy Rachala, Sathun Dharmender Reddy, K Sena Devi, Md Yaser Ahmed Khan
Objective: To evaluate shear bond strength (SBS) of Ormocer-bonded orthodontic brackets with self-etching primer (SEP) and conventional adhesive system and also to assess the amount of adhesive remaining on the tooth surface after debonding using adhesive remnant index (ARI). Materials and Methods: The study was done on 90 extracted human upper first permanent maxillary premolars. The study sample was categorized into three groups of 30 each to assess the SBS using three adhesives, Ormocer, SEP, and conventional adhesive system...
January 2018: Journal of International Society of Preventive & Community Dentistry
Richard Knochenmuss, Rajeev K Sinha, Samuel Leutwyler
We measured accurate intermolecular dissociation energies D0 of the supersonic jet-cooled complexes of 1-naphthol (1NpOH) with the noble gases Ne, Ar, Kr, and Xe and with N2 , using the stimulated-emission pumping resonant two-photon ionization method. The ground-state values D0 (S0 ) for the 1NpOH⋅S complexes with S= Ar, Kr, Xe, and N2 were bracketed to be within ±3.5%; they are 5.67 ± 0.05 kJ/mol for S = Ar, 7.34 ± 0.07 kJ/mol for S = Kr, 10.8 ± 0.28 kJ/mol for S = Xe, 6.67 ± 0.08 kJ/mol for isomer 1 of the 1NpOH⋅N2 complex, and 6...
April 7, 2018: Journal of Chemical Physics
Jing Huang, Cui-Ying Li, Jiu-Hui Jiang
BACKGROUND: This systematic review and meta-analysis aimed to identify whether there is any relationship between fixed orthodontic appliances and malodor, and if self-ligating brackets (SLBs) prevent malodor better than conventional brackets (CBs). METHODS: The electronic databases PubMed, Ovid, EMBASE, and the Cochrane Library were searched from inception to September 2016; a manual search was also performed. Randomized controlled and clinical controlled trials, in which experimental groups received fixed orthodontic therapy and malodor was measured, were included...
April 2018: Medicine (Baltimore)
Samúel Sigurðsson, Elias Eythorsson, Birgir Hrafnkelsson, Helga Erlendsdóttir, Karl G Kristinsson, Ásgeir Haraldsson
Background: The 10-valent pneumococcal conjugate vaccine (PHiD-CV10) was introduced in Iceland in 2011, without catch-up. The aim of this study was to estimate vaccine impact on acute otitis media (AOM). Methods: In this whole-population study, all primary care visits due to AOM from 2005-2015 in children less than three years of age were included. Birth-cohorts were grouped as vaccine non-eligible (VNEC, 2005-2010) or vaccine eligible (VEC, 2011-2015). Crude incidence rates (IR) were compared between VNEC and VEC...
March 30, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Emilija Bajraktarova-Valjakova, Anita Grozdanov, Ljuben Guguvcevski, Vesna Korunoska-Stevkovska, Biljana Kapusevska, Nikola Gigovski, Aneta Mijoska, Cvetanka Bajraktarova-Misevska
AIM: The purpose of this review is to represent acids that can be used as surface etchant before adhesive luting of ceramic restorations, placement of orthodontic brackets or repair of chipped porcelain restorations. Chemical reactions, application protocol, and etching effect are presented as well. STUDY SELECTION: Available scientific articles published in PubMed and Scopus literature databases, scientific reports and manufacturers' instructions and product information from internet websites, written in English, using following search terms: "acid etching, ceramic surface treatment, hydrofluoric acid, acidulated phosphate fluoride, ammonium hydrogen bifluoride", have been reviewed...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
M M Almuqbel, G J Leeper, J F Petelo, T J Page, T R Melzer
Magnetic susceptibility artefacts, caused by metallic objects, present a challenge in magnetic resonance imaging (MRI). In this case, MRI showed metal-induced artefact in the rectum of a 14-year-old girl who presented with pain in the coccyx after a snowboarding accident. Previous radiographs showed no evidence of metal in the area. After the identification of the artefact and upon discussion with the patient, she disclosed that two orthodontic brackets had been swallowed two days prior to the MRI examination, likely the source of artefact...
May 2018: Radiography
Varadaraju Magesh, Pandurangan Harikrishnan, Devadhas Kingsly Jeba Singh
INTRODUCTION: Torque applied on anterior teeth is vital for root positioning and stability. The aim of this study was to evaluate the detailed slot wall deformation in stainless steel (SS) and titanium (Ti) edgewise brackets during palatal root torque using finite element analysis. METHODS: A finite element model was developed from a maxillary central incisor SS bracket (0.022 in). The generated torque values from an SS rectangular archwire (0.019 × 0.025 in) while twisting from 5° to 40° were obtained experimentally by a spine tester, and the calculated torque force was applied in the bracket slot...
April 2018: American Journal of Orthodontics and Dentofacial Orthopedics
Kashappa Goud Desai, Hirokazu Obayashi, James D Colandene, Douglas P Nesta
Japan represents the third largest pharmaceutical market in the world. Developing a new biopharmaceutical drug product for the Japanese market is a top business priority for global pharmaceutical companies while aligning with ethical drivers to treat more patients in need. Understanding Japan-specific key regulatory requirements is essential to achieve successful approvals. Understanding the full context of Japan-specific regulatory requirements/expectations is challenging to global pharmaceutical companies due to differences in language and culture...
March 27, 2018: Journal of Pharmaceutical Sciences
Sebastian Kohl, Jan Schoenfelder, Andreas Fügener, Jens O Brunner
The original version of this article unfortunately contained errors. The first column of Tables 5 and 6 in the Appendix section should contain the year of publication instead of the reference number in brackets. The reference citations were then placed in the second column.
March 29, 2018: Health Care Management Science
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