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thyroid AND meta-analysis

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https://www.readbyqxmd.com/read/29774010/efficacy-of-vandetanib-in-treating-locally-advanced-or-metastatic-medullary-thyroid-carcinoma-according-to-recist-criteria-a-systematic-review-and-meta-analysis
#1
Pierpaolo Trimboli, Marco Castellana, Camilla Virili, Francesco Giorgino, Luca Giovanella
Background: Vandetanib is the most largely used tyrosine kinase inhibitor (TKI) in patients with locally advanced and/or metastatic medullary thyroid cancer (MTC). Here, we conducted a systematic review on its efficacy and attempted to perform a meta-analysis adopting standardized RECIST criteria as end-points. Methods: The terms "medullary thyroid" and "protein kinase inhibitor" (then including all TKIs) were searched in PubMed, ClinicalTrials...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29765404/meta-analysis-of-the-association-between-vitamin-d-receptor-polymorphisms-and-the-risk-of-autoimmune-thyroid-disease
#2
Xue-Ren Gao, Yong-Guo Yu
The association between vitamin D receptor ( VDR ) polymorphisms (rs731236, rs1544410, rs2228570, and rs7975232) and the risk of autoimmune thyroid disease (AITD) had been investigated in previous studies. However, the results of these studies remained controversial. Thus, a meta-analysis was performed to derive a more precise conclusion. All related articles were systematically searched by PubMed, Embase, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29761266/evaluation-of-thyroid-gland-as-an-organ-at-risk-after-breast-cancer-radiotherapy-a-systematic-review-and-meta-analysis
#3
REVIEW
L Darvish, M Ghorbani, S Hosseini Teshnizi, N Roozbeh, F Seif, M Reza Bayatiani, C Knaup, A Amraee
BACKGROUND: Radiotherapy can often lead to thyroid dysfunction. Some studies demonstrated that treatment of breast cancer by RT can expose thyroid gland to high doses of radiation. The aim of this systematic review is to evaluate consideration of thyroid gland as an organ at risk. METHODS: In this systematic review and meta-analysis to select initial studies, a comprehensive search by two independent reviewers was performed. Electronical databases following: Web of Science, Google Scholar, Scopus, PubMed, Elsevier, Embase, ProQuest and Persian databases such as Iranmedex, Magiran, and SID were searched...
May 14, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29757392/thyroid-function-in-early-pregnancy-child-iq-and-autistic-traits-a-meta-analysis-of-individual-participant-data
#4
Deborah Levie, Tim I M Korevaar, Sarah C Bath, Albert Dalmau-Bueno, Mario Murcia, Mercedes Espada, Mariana Dineva, Jesús M Ibarluzea, Jordi Sunyer, Henning Tiemeier, Marisa Rebagliato, Margaret P Rayman, Robin P Peeters, Mònica Guxens
Context: Low maternal free thyroxine (FT4) has been associated with poor child neurodevelopment in some single-centre studies. Evidence remains scarce for potential adverse effects of high FT4 and whether associations differ in countries with a different iodine status. Objective: To assess the association of maternal thyroid function in early pregnancy with child neurodevelopment in countries with a different iodine status. Design, Setting and Participants: Meta-analysis of individual-participant data compromising 9,036 mother-child pairs from three prospective population-based birth cohorts: INMA (Spain), Generation R (The Netherlands) and ALSPAC (United Kingdom)...
May 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29747656/maternal-drug-use-and-the-risk-of-anorectal-malformations-systematic-review-and-meta-analysis
#5
REVIEW
Nadine Zwink, Ekkehart Jenetzky
BACKGROUND: Origin of anorectal malformations (ARM) are considered multifactorial. Several genetic and non-genetic risk factors are discussed in literature. Maternal periconceptional medical drug use as possible risk factor, however, has not been reviewed systematically. METHODS: Studies published between 1977 and April 2017 were reviewed through systematic search in PubMed, ISI Web of Knowledge and Scopus databases. Furthermore, related and cross-referencing publications were reviewed...
May 10, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29746532/association-between-perfluoroalkyl-substances-exposure-and-thyroid-function-in-adults-a-meta-analysis
#6
Min Joo Kim, Shinje Moon, Byung-Chul Oh, Dawoon Jung, Kyunghee Ji, Kyungho Choi, Young Joo Park
OBJECTIVE: Many people are exposed to perfluoroalkyl substances (PFASs) because these substances are widely used as industrial products. Although epidemiological studies suggest that PFASs can disrupt thyroid hormones, the association between PFAS exposure and thyroid function remains inconclusive. Therefore, we performed a comprehensive meta-analysis to investigate the association between PFASs exposure and thyroid hormones. METHODS: We searched medical literature databases for articles on the association between PFASs-perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS)-and thyroid hormone levels in adults...
2018: PloS One
https://www.readbyqxmd.com/read/29742978/needle-biopsy-of-routine-thyroid-nodules-should-be-performed-using-a-capillary-action-technique-with-24-27-gauge-needles-a-systematic-review-and-meta-analysis
#7
William Moss, Andrey Finegersh, John Pang, Joseph A Califano, Charles S Coffey, Ryan Orosco, Kevin T Brumund
BACKGROUND: Fine needle biopsy is the international standard for diagnostic evaluation of thyroid nodules. There is a lack of consensus regarding the optimal fine needle biopsy technique. The implementation of capillary action versus aspiration and the optimal needle gauge remain topics of debate. METHODS: A systematic review of the Medline, Embase and Cochrane databases was performed in accordance with PRISMA guidelines. Articles evaluating the effects of capillary action vs...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29724531/long-non-coding-rna-polr2e-rs3787016-is-associated-with-the-risk-of-papillary-thyroid-carcinoma-in-chinese-population
#8
Bifeng Chen, Jinfeng Li, Can Yi, Yuwei Jiao, Xiuli Gu, Xianhong Feng
Long non-coding RNAs (LncRNAs) have been shown to be involved in cancer tumorigenesis and progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. We here explored the association between POLR2E rs3787016 and risk of papillary thyroid carcinoma (PTC) in a Chinese population, which was followed by a meta-analysis of POLR2E rs3787016 and cancer risk in Chinese population. A total of 409 PTC patients and 800 healthy individuals were enrolled in the present study...
April 17, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29719407/evidence-from-an-updated-meta-analysis-of-the-prognostic-impacts-of-postoperative-radiotherapy-and-chemotherapy-in-patients-with-anaplastic-thyroid-carcinoma
#9
Quansong Xia, Wei Wang, Juan Xu, Xue Chen, Zhaoming Zhong, Chuanzheng Sun
Background: Radiotherapy and chemotherapy are the two important postoperative management approaches for anaplastic thyroid carcinoma (ATC), and several studies have suggested that postoperative radiotherapy and chemotherapy can prolong the survival of patients with ATC. However, the results remain inconsistent. Objective: A meta-analysis was performed to address whether postoperative radiotherapy and chemotherapy could prolong the survival of patients with ATC. Methods: Relevant studies were included, and pooled hazard ratios (HRs) together with 95% confidence intervals (CIs) were calculated...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29693784/meta-analysis-of-the-incidence-and-patterns-of-second-neoplasms-after-photon-craniospinal-irradiation-in-children-with-medulloblastoma
#10
Abhishek Bavle, Sayani Tewari, Amy Sisson, Murali Chintagumpala, Michael Anderson, Arnold C Paulino
BACKGROUND: Second neoplasms (SNs) are a well-established long-term adverse effect of radiation therapy (RT), but there are limited data regarding their incidence and location relative to the radiation field, specific to medulloblastoma (MB) survivors after craniospinal irradiation (CSI). METHODS: A systematic literature review, per Preferred Reporting Items for Systematic Reviews and Meta-Analyses, identified six studies reporting the incidence and locations of SNs for 1,114 patients with MB, after CSI, with a median follow-up of ∼9 years (7...
April 25, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29691475/author-correction-prognostic-value-of-thyroid-hormones-in-acute-ischemic-stroke-a-meta-analysis
#11
Xingjun Jiang, Hongyi Xing, Jing Wu, Ruofei Du, Houfu Liu, Jixiang Chen, Ji Wang, Chen Wang, Yan Wu
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29684213/low-thyroid-function-is-not-associated-with-an-accelerated-deterioration-in-renal-function
#12
Christiaan L Meuwese, Merel van Diepen, Anne R Cappola, Mark J Sarnak, Michael G Shlipak, Douglas C Bauer, Linda P Fried, Massimo Iacoviello, Bert Vaes, Jean Degryse, Kay-Tee Khaw, Robert N Luben, Bjørn O Åsvold, Trine Bjøro, Lars J Vatten, Anton J M de Craen, Stella Trompet, Giorgio Iervasi, Sabrina Molinaro, Graziano Ceresini, Luigi Ferrucci, Robin P F Dullaart, Stephan J L Bakker, J Wouter Jukema, Patricia M Kearney, David J Stott, Robin P Peeters, Oscar H Franco, Henry Völzke, John P Walsh, Alexandra Bremner, José A Sgarbi, Rui M B Maciel, Misa Imaizumi, Waka Ohishi, Friedo W Dekker, Nicolas Rodondi, Jacobijn Gussekloo, Wendy P J den Elzen
Background: Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Methods: Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29678681/genome-wide-meta-analysis-identifies-novel-gender-specific-loci-associated-with-thyroid-antibodies-level-in-croatians
#13
Antonela Matana, Marijana Popović, Thibaud Boutin, Vesela Torlak, Dubravka Brdar, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Ozren Polašek, Caroline Hayward, Maja Barbalić, Tatijana Zemunik
Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta-analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. No significant association was detected with the level of TgAb and TPOAb in the meta-analysis of GWAS or bivariate results for all individuals...
April 17, 2018: Genomics
https://www.readbyqxmd.com/read/29665745/heterogeneity-in-ppv-of-ras-mutations-in-cytologically-indeterminate-thyroid-nodules
#14
Fadi Nabhan, Kyle Porter, Mark Lupo, Gregory W Randolph, Kepal Narendra Patel, Richard T Kloos
BACKGROUND: RAS mutations are common in the available mutational analysis of cytologically indeterminate (Cyto-I) thyroid nodules. However, their reported positive predictive value (PPV) for cancer is widely variable. The reason for this variability is unknown and it causes clinical management uncertainty. We performed a systematic review evaluating the PPV for cancer in RAS mutation positive Cyto-I nodules and considered variables that might affect residual heterogeneity across the different studies...
April 18, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29663106/prevalence-of-thyroid-diseases-in-familial-adenomatous-polyposis-a-systematic-review-and-meta-analysis
#15
Jirat Chenbhanich, Amporn Atsawarungruangkit, Sira Korpaisarn, Tanit Phupitakphol, Soravis Osataphan, Prasit Phowthongkum
Thyroid cancer (TC) is a known extra-intestinal manifestation and contributes to the mortality and morbidity in patients with familial adenomatous polyposis (FAP). Its exact prevalence is not well established and recent studies have shown an increasing number of TC in this patient population. The prevalence of benign thyroid masses and endocrinologic thyroid disorders are also poorly described. We conducted a systematic review and meta-analysis by using a random-effects model to characterize TC and estimated the prevalence of thyroid diseases in FAP patients...
April 16, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29662643/correction-a-comparison-of-the-clinicopathological-features-and-prognoses-of-the-classical-and-the-tall-cell-variant-of-papillary-thyroid-cancer-a-meta-analysis
#16
Zeming Liu, Wen Zeng, Tianwen Chen, Yawen Guo, Chao Zhang, Chunping Liu, Tao Huang
[This corrects the article DOI: 10.18632/oncotarget.14055.].
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29625265/network-based-meta-analysis-in-the-identification-of-biomarkers-for-papillary-thyroid-cancer
#17
Hengqiang Zhao, Hehe Li
Papillary thyroid carcinoma (PTC) has been increasing across the world with incomplete understanding of its pathogenesis. We aimed to investigate gene alterations and biomarkers contributing to PTC development. A total of five eligible microarray datasets including 94 PTC and 81 normal thyroid samples were included to identify gene expression signatures. Using integrative meta-analysis of expression data (INMEX) program, we identified a total of 2699 differentially expressed genes (DEGs) (1333 overexpressed and 1366 underexpressed genes) in PTC relative to normal thyroid samples...
April 3, 2018: Gene
https://www.readbyqxmd.com/read/29615431/clinical-significance-of-ret-and-ras-mutations-in-sporadic-medullary-thyroid-cancer-a-meta-analysis
#18
Huy Gia Vuong, Toru Odate, Hanh T T Ngo, Thong Quang Pham, Thao T K Tran, Kunio Mochizuki, Tadao Nakazawa, Ryohei Katoh, Tetsuo Kondo
There are ongoing debates with respect to the prognostic roles of molecular biomarkers in sporadic medullary thyroid carcinoma (MTC). In this study, we aimed at investigating the prognostic value of RET and RAS mutations - the two most common mutations in sporadic MTCs. A search was conducted in four electronic databases. Relevant data were extracted and pooled into odds ratios (OR), mean differences (MD) and corresponding 95% confidence intervals (CI) using the random-effect model. We used Egger's regression test and visual of funnel plots to assess the publication bias...
April 3, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29596650/micronutrients-iodine-status-and-concentrations-of-thyroid-hormones-a-systematic-review
#19
S Maria O'Kane, Maria S Mulhern, L Kirsty Pourshahidi, J J Strain, Alison J Yeates
Context: The metabolism of thyroid hormones, which are essential for normal development, involves many proteins and enzymes. It requires iodine as a key component but is also influenced by several other micronutrients, including selenium, zinc, iron, and vitamin A. Objective: This systematic review was designed to investigate the effect of micronutrient status and supplementation on iodine status and thyroid hormone concentrations. Data Sources: Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines, electronic databases were searched from their inception to April 2016...
March 27, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29594049/positron-emission-tomography-pet-and-pet-ct-in-thyroid-cancer-a-systematic-review-and-meta-analysis
#20
Friederike Schütz, Christine Lautenschläger, Kerstin Lorenz, Johannes Haerting
Background: Positron emission tomography (PET) and PET/CT are functional imaging methods that are widely used in diagnostic procedures in oncology. Objectives: The objective of this study was to assess the patient-relevant benefit of PET or PET/CT in patients with thyroid cancer based on a literature review and meta-analysis. Methods: A systematic review including studies that had been published until December 2013 was performed. To be included, studies had to prospectively investigate patients with thyroid cancer in a clinical setting of staging, restaging, or diagnosing tumour recurrence...
January 2018: European Thyroid Journal
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