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thyroid AND meta-analysis

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https://www.readbyqxmd.com/read/29145283/the-relationship-between-rassf1a-promoter-methylation-and-thyroid-carcinoma-a-meta-analysis-of-14-articles-and-a-bioinformatics-of-2-databases-prisma
#1
Heng Niu, Jingyu Yang, Kunxian Yang, Yingze Huang
BACKGROUND: DNA promoter methylation can suppresses gene expression and shows an important role in the biological functions of Ras association domain family 1A (RASSF1A). Many studies have performed to elucidate the role of RASSF1A promoter methylation in thyroid carcinoma, while the results were conflicting and heterogeneous. Here, we analyzed the data of databases to determine the relationship between RASSF1A promoter methylation and thyroid carcinoma. METHODS: We used the data from 14 cancer-normal studies and Gene Expression Omnibus (GEO) database to analyze RASSF1A promoter methylation in thyroid carcinoma susceptibility...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144823/the-relationship-of-braf-v600e-mutation-status-to-fdg-pet-ct-avidity-in-thyroid-cancer-a-review-and-meta-analysis
#2
Prasanna Santhanam, Rodhan Khthir, Lilja B Solnes, Paul W Ladenson
OBJECTIVES: Papillary thyroid cancers harboring BRAF (V600E) gene mutation have been shown to exhibit aggressive tumor behaviors and higher risks of recurrence and disease-specific death. In this systematic review and meta-analysis, we examine and report published evidence related to the accuracy of FDG-PET-CT in detection of residual disease in patients' with BRAF (V600E) mutated thyroid cancer. METHODS: We extracted data from PUBMED/MEDLINE and EMBASE from January, 1995 to March, 2017...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29137336/percutaneous-laser-ablation-for-benign-thyroid-nodules-a-meta-analysis
#3
Wei Fan Sui, Jian Yun Li, Jian Hua Fu
Purpose: To evaluate percutaneous laser ablation in treating benign thyroid nodules, we conducted a meta-analysis based on summarizing existing researches. Materials and Methods: A literature search for clinical trial was performed in PubMed, Cochrane Library and Excerpt Medica Database. The qualities of included studies were evaluated. We calculated the indexes with mean difference. Heterogeneity and publication bias were tested and explored. We performed subgroup analyses and sensitivity analysis further...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29119458/efficacy-of-radioiodine-therapy-for-treating-20-patients-with-pulmonary-metastases-from-differentiated-thyroid-cancer-and-a-meta-analysis-of-the-current-literature
#4
X Zhang, D-S Liu, Z-S Luan, F Zhang, X-H Liu, W Zhou, S-F Zhong, H Lai
BACKGROUND: Radioiodine therapy (RAI) after total or near-total thyroidectomy is a recommended treatment for patients with pulmonary metastasis from differentiated thyroid cancer (DTC). However, the total effective rate of iodine-131 therapy remains controversial. This study aimed to determine the efficacy of RAI for treating patients with pulmonary metastasis from DTC, and to identify independent predictors of its efficacy. METHODS: We conducted a retrospective study to evaluate 20 patients with pulmonary metastasis from DTC who underwent RAI at our center at first and performed a meta-analysis to evaluate relevant literature regarding the overall efficacy of RAI and subgroup-specific efficacies subsequently...
November 8, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29099543/vitamin-d-supplementation-for-chronic-liver-diseases-in-adults
#5
REVIEW
Goran Bjelakovic, Dimitrinka Nikolova, Marko Bjelakovic, Christian Gluud
BACKGROUND: Vitamin D deficiency is often reported in people with chronic liver diseases. Therefore, improving vitamin D status could have a beneficial effect on people with chronic liver diseases. OBJECTIVES: To assess the beneficial and harmful effects of vitamin D supplementation in people with chronic liver diseases. SEARCH METHODS: We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, Science Citation Index Expanded, and Conference Proceedings Citation Index - Science...
November 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29093678/immune-related-adverse-events-associated-with-anti-pd-1-pd-l1-treatment-for-malignancies-a-meta-analysis
#6
Peng-Fei Wang, Yang Chen, Si-Ying Song, Ting-Jian Wang, Wen-Jun Ji, Shou-Wei Li, Ning Liu, Chang-Xiang Yan
Background: Treatment of cancers with programmed cell death protein 1 (PD-1) pathway inhibitors can lead to immune-related adverse events (irAEs), which could be serious and even fetal. Therefore, clinicians should be aware of the characteristics of irAEs associated with the use of such drugs. Methods: The MEDLINE, EMBASE, and Cochrane databases were searched to find potential studies using the following strategies: anti-PD-1/PD-L1 treatment; irAEs; and cancer. R© package Meta was used to pool incidence. Results: Forty-six studies representing 12,808 oncologic patients treated with anti-PD-1/PD-L1 agents were included in the meta-analysis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29081800/relationship-between-subclinical-thyroid-dysfunction-and-the-risk-of-cardiovascular-outcomes-a-systematic-review-and-meta-analysis-of-prospective-cohort-studies
#7
REVIEW
Jing Sun, Liang Yao, Yuan Fang, Ruifei Yang, Yaolong Chen, Kehu Yang, Limin Tian
BACKGROUND: Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND RESULTS: PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies were included for meta-analysis. We found that subclinical hypothyroidism was not correlated with coronary heart disease (CHD) (RR = 1.17; 95% CI, 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29068996/diagnostic-potential-of-real-time-elastography-rte-and-shear-wave-elastography-swe-to-differentiate-benign-and-malignant-thyroid-nodules-a-systematic-review-and-meta-analysis
#8
REVIEW
Xiangdong Hu, Yujiang Liu, Linxue Qian
BACKGROUND: Real-time elastography (RTE) and shear wave elastography (SWE) are noninvasive and easily available imaging techniques that measure the tissue strain, and it has been reported that the sensitivity and the specificity of elastography were better in differentiating between benign and malignant thyroid nodules than conventional technologies. METHODS: Relevant articles were searched in multiple databases; the comparison of elasticity index (EI) was conducted with the Review Manager 5...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29058277/relationship-between-expression-of-vascular-endothelial-growth-factor-and-cervical-lymph-node-metastasis-in-papillary-thyroid-cancer-a-meta-analysis
#9
Xiao-Qing Huang, Wen-Shan He, Hui-Qiong Zhang, Rui Yang, Tao Huang
The aim of the present study was to examine the relationship between the protein expression of vascular endothelial growth factor (VEGF) and lymph node metastasis (LNM) in papillary thyroid cancer (PTC). VEGF-related articles that had been published until August 2016 were searched from the PubMed, EMBASE, and MEDLINE to identify the risk factors of LNM in PTC. RevMan 5.3 software was used for the meta-analysis. Finally, 9 articles met the inclusion criteria and were included in our meta-analysis. LNM was found to be present in 176 of 318 patients (57...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29054676/is-diagnostic-performance-of-quantitative-2d-shear-wave-elastography-optimal-for-clinical-classification-of-benign-and-malignant-thyroid-nodules-a-systematic-review-and-meta-analysis
#10
Haliimah A Nattabi, Norhafidzah M Sharif, Noorazrul Yahya, Rozilawati Ahmad, Mazlyfarina Mohamad, Faizah M Zaki, Ahmad N Yusoff
RATIONALE AND OBJECTIVE: This study is a dedicated 2D-shear wave elastography (2D-SWE) review aimed at systematically eliciting up-to-date evidence of its clinical value in differential diagnosis of benign and malignant thyroid nodules. METHODS: PubMed, Web of Science, and Scopus databases were searched for studies assessing the diagnostic value of 2D-SWE for thyroid malignancy risk stratification published until December 2016. The retrieved titles and abstracts were screened and evaluated according to the predefined inclusion and exclusion criteria...
October 17, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29043757/there-is-no-association-between-the-presence-of-anti-thyroid-antibodies-and-increased-reproductive-loss-in-pregnant-women-after-art-a-systematic-review-and-meta-analysis
#11
REVIEW
Paz Leiva, Juan Enrique Schwarze, Pamela Vasquez, Carolina Ortega, Sonia Villa, Javier Crosby, José Balmaceda, Ricardo Pommer
Women submitted to ART treatments represent a select subgroup of individuals. Several studies have described the relationship between TAI and pregnancy outcomes as a result of ART, with contradictory results. The purpose of this systematic review was to determine the association between TAI and the risk of miscarriage in pregnancies resulting from ART. MEDLINE via PubMed, LILACS and Embase were searched for studies published in peer-reviewed journals from 1999 to 2017. The studies were summarized using the fixed effects model and the Peto's method to calculate RR in order to flesh out the association between TAI and spontaneous abortion...
October 18, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29039052/effect-of-bariatric-surgery-on-thyroid-function-in-obese-patients-a-systematic-review-and-meta-analysis
#12
REVIEW
Bingsheng Guan, YanYa Chen, Jingge Yang, Wah Yang, Cunchuan Wang
We aimed to make a meta-analysis regarding the effect of bariatric surgery on thyroid function in obese patients. PubMed, EMBASE, CENTRAL, and four Chinese databases were searched for clinical studies. Data were pooled using Review Manager 5.3, and subgroup and sensitivity analyses were performed if necessary and feasible. As a result, 24 articles were included into meta-analysis. Bariatric surgery was associated with significant decrease in TSH, FT3, and T3 levels. However, FT4, T4, and rT3 levels were not significantly changed postoperatively...
October 16, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29037127/role-of-molecular-markers-to-predict-distant-metastasis-in-papillary-thyroid-carcinoma-promising-value-of-tert-promoter-mutations-and-insignificant-role-of-braf-mutations-a-meta-analysis
#13
Huy Gia Vuong, Ahmed Ma Altibi, Uyen Np Duong, Hanh Tt Ngo, Thong Quang Pham, Hung Minh Tran, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh, Tetsuo Kondo
The presence of distant metastasis is associated with an adverse outcome in papillary thyroid cancer. We performed a meta-analysis to investigate the role of molecular markers as predictors for distant metastasis in papillary thyroid cancer. Four electronic databases including PubMed, Web of Science, Scopus, and Virtual Health Library were searched, and odds ratio and its 95% confidence interval concerning the association of BRAF, RAS, and TERT promoter mutations and RET/PTC rearrangements with distant metastasis were calculated using random-effects model...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29018157/can-liquid-based-preparation-substitute-for-conventional-smear-in-thyroid-fine-needle-aspiration-a-systematic-review-based-on-meta-analysis
#14
Yosep Chong, Soon-Jin Ji, Chang Suk Kang, Eun Jung Lee
OBJECTIVE: Conventional smear (CS) using fine-needle aspiration cytology (FNAC) has been established as the test of choice for diagnosing thyroid lesions, despite low sample adequacy and inter-individual variations. Although a liquid-based preparation (LBP) technique has been recently applied to overcome these limitations, its clinical utility and its accuracy over CS are controversial. This study aimed to determine the true sensitivity and specificity of LBP in thyroid FNAC by meta-analysis...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28994274/thyroid-cytology-in-india-contemporary-review-and-meta-analysis
#15
Shipra Agarwal, Deepali Jain
Fine needle aspiration cytology (FNAC) is a screening test for triaging thyroid nodules, aiding in subsequent clinical management. However, the advantages have been overshadowed by the multiplicity of reporting systems and a wide range of nomenclature used. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was formulated in 2007, to give the world a uniform thyroid cytology reporting system, facilitating easy interpretation by the clinicians. Here, we review the status of thyroid FNAC in India in terms of various reporting systems used including a meta-analysis of the previously published data...
October 5, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28977955/a-meta-analysis-of-hashimoto-s-thyroiditis-and-papillary-thyroid-carcinoma-risk
#16
Xingjian Lai, Yu Xia, Bo Zhang, Jianchu Li, Yuxin Jiang
OBJECTIVE: It remains inconclusive whether Hashimoto's thyroiditis (HT) predisposes patients to the development of papillary thyroid carcinoma (PTC). We conducted a meta-analysis of the available data to address this question. RESULTS: Twenty-seven eligible studies were selected, including 18 archival thyroidectomy studies, 6 fine-needle aspiration (FNA) studies, and 3 selective FNA or thyroidectomy studies. A total of 76,281 patients, including 12,476 cases of thyroid cancer, were included in these studies...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977647/attributable-risk-fraction-of-four-lifestyle-risk-factors-of-thyroid-cancer-a-meta-analysis
#17
Hajar Sadeghi, Mohammad Rafei, Masoud Bahrami, AliAkbar Haghdoost, Yazdan Shabani
Background: Lifestyle risk factors such as obesity, overweight, smoking and radiation exposure related to thyroid cancer. This study estimated the amount of excess risk that attributed to risk factors. Methods: Major electronic databases were searched until February 2016. Epidemiological studies addressing the association between lifestyle risk factors and thyroid cancer were enrolled. The results were expressed as ARF with 95% confidence intervals (CIs) using a random-effects-model...
August 9, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28973656/incidence-of-endocrine-dysfunction-following-the-use-of-different-immune-checkpoint-inhibitor-regimens-a-systematic-review-and-meta-analysis
#18
Romualdo Barroso-Sousa, William T Barry, Ana C Garrido-Castro, F Stephen Hodi, Le Min, Ian E Krop, Sara M Tolaney
Importance: If not promptly recognized, endocrine dysfunction can be life threatening. The incidence and risk of developing such adverse events (AEs) following the use of immune checkpoint inhibitor (ICI) regimens are unknown. Objective: To compare the incidence and risk of endocrine AEs following treatment with US Food and Drug Administration-approved ICI regimens. Data Sources: A PubMed search through July 18, 2016, using the following keywords was performed: "ipilimumab," "MDX-010," "nivolumab," "BMS-963558," "pembrolizumab," "MK-3475," "atezolizumab," "MPDL3280A," and "phase...
September 28, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28971654/-surgical-treatment-of-locally-advanced-well-differentiated-thyroid-carcinoma
#19
Shorook Na'ara, Moran Amit, Salem Billan, Jacob Cohen, Ziv Gil
AIMS: We aimed to better define the most appropriate therapeutic protocol for this type of tumor. BACKGROUND: The incidence of well-differentiated thyroid carcinoma is rising and the mortality from the disease remains low for patients with early disease. Nevertheless, the survival of patients with advanced disease has not improved during the last four decades and a controversy still exists in the literature regarding the optimal treatment in patients with locally advanced (T4) differentiated thyroid carcinoma...
September 2017: Harefuah
https://www.readbyqxmd.com/read/28942234/second-generation-of-familial-nonmedullary-thyroid-carcinoma-a-meta-analysis-on-the-clinicopathologic-features-and-prognosis
#20
REVIEW
Yi-Mei Zhou, Han Luo, Ju-Xiang Gou, Wan-Jun Zhao, Wen-Yu Dai, Jingqiang Zhu, Zhi-Hui Li
Whether the second generation of parent/offspring type familial nonmedullary thyroid carcinoma (FNMTC) is more aggressive and has worse prognosis than their first generation counterpart is controversial. To evaluate the clinicopathologic features and prognosis of the second generation via a comparison between the two groups, We searched three databases (PubMed, EMBASE and the Cochrane library) to review studies published before November 25, 2016. All original studies comparing the clinicopathologic features and prognosis in the first generation of parent/offspring type FNMTC with its second generation counterpart were included...
September 12, 2017: European Journal of Surgical Oncology
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