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thyroid AND meta-analysis

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https://www.readbyqxmd.com/read/27920278/a-meta-analysis-of-the-association-of-serum-ischemia-modified-albumin-levels-with%C3%A2-human-hypothyroidism-and-hyperthyroidism
#1
Varikasuvu Seshadri Reddy, Suman Bukke, Khageshwar Mahato, Vinod Kumar, Netala Vasudeva Reddy, Manne Munikumar
BACKGROUND: Serum levels of ischemia-modified albumin (IMA) have been studied as a novel and simple measure of oxidative stress (OXS) in different thyroid pathologies. However, results of available studies in the literature were not consistent. This meta-analysis was attempted to quantify the overall effect size for serum IMA levels in human hypothyroidism (HT) and hyperthyroidism (HYT) and to study its associations with the thyroid profile. METHODS: Databases of PubMed/Medline, EMBASE, Google Scholar, Web of Science and Science Direct were searched for articles...
December 5, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27913945/the-effect-of-prophylactic-central-neck-dissection-on-locoregional-recurrence-in-papillary-thyroid-cancer-after-total-thyroidectomy-a-systematic-review-and-meta-analysis-pcnd-for-the-locoregional-recurrence-of-papillary-thyroid-cancer
#2
Wenjing Zhao, Lei You, Xianming Hou, Shaobo Chen, Xiaoxia Ren, Ge Chen, Yupei Zhao
BACKGROUND: The use of prophylactic central neck dissection (pCND) for papillary thyroid cancer (PTC) without clinical evidence of nodal metastasis (cN0) remains controversial. This study was designed to examine whether pCND for PTC affected locoregional recurrence (LRR). METHODS: A systematic review was performed to compare the LRR between patients with PTC who underwent total thyroidectomy (TT) and pCND and those who underwent TT alone. The primary outcome was LRR...
December 2, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27882800/development-of-sorafenib-related-side-effects-in-patients-diagnosed-with-advanced-hepatocellular-carcinoma-treated-with-sorafenib-a-systematic-review-and-meta-analysis-of-the-impact-on-survival
#3
Omar Abdel-Rahman, Angela Lamarca
​Introduction: Clinical markers to predict the benefit from sorafenib in patients diagnosed with hepatocellular carcinoma (HCC) are lacking. A meta-analysis exploring the impact of development of sorafenib-related side effects on survival was conducted. Areas covered: Eligible studies included all clinical studies reporting on the survival/toxicity relationship in sorafenib-treated HCC patients. Data sources included Pub-Med, the Cochrane Controlled Trials Register, and Google scholar. After exclusion of ineligible studies, 16 studies were included in the analysis...
November 30, 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27852042/toxicity-profile-of-approved-anti-pd-1-monoclonal-antibodies-in-solid-tumors-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#4
REVIEW
Ricardo Costa, Benedito A Carneiro, Mark Agulnik, Alfred W Rademaker, Sachin G Pai, Victoria M Villaflor, Massimo Cristofanilli, Jeffrey A Sosman, Francis J Giles
PURPOSE: Nivolumab and pembrolizumab are antibodies against the programmed-death-receptor- 1 (PD-1) which are associated with distinct immune related adverse effects (AEs). This meta-analysis of randomized clinical trials aims to summarize current knowledge regarding the toxicity profile of these agents. METHODS: PubMed search was conducted in February of 2016. The randomized trials needed to have at least one of the study arms consisting of nivolumab or pembrolizumab monotherapy and a control arm containing no anti-PD-1 therapy...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27848077/identification-of-new-trip12-variants-and-detailed-clinical-evaluation-of-individuals-with-non-syndromic-intellectual-disability-with-or-without-autism
#5
Nuria C Bramswig, H-J Lüdecke, M Pettersson, B Albrecht, R A Bernier, K Cremer, E E Eichler, D Falkenstein, J Gerdts, S Jansen, A Kuechler, M Kvarnung, A Lindstrand, D Nilsson, A Nordgren, R Pfundt, L Spruijt, H M Surowy, B B A de Vries, T Wieland, H Engels, T M Strom, T Kleefstra, D Wieczorek
The ubiquitin pathway is an enzymatic cascade including activating E1, conjugating E2, and ligating E3 enzymes, which governs protein degradation and sorting. It is crucial for many physiological processes. Compromised function of members of the ubiquitin pathway leads to a wide range of human diseases, such as cancer, neurodegenerative diseases, and neurodevelopmental disorders. Mutations in the thyroid hormone receptor interactor 12 (TRIP12) gene (OMIM 604506), which encodes an E3 ligase in the ubiquitin pathway, have been associated with autism spectrum disorder (ASD)...
November 15, 2016: Human Genetics
https://www.readbyqxmd.com/read/27834461/clinicopathological-significance-of-loss-of-p27kip1-expression-in-papillary-thyroid-carcinoma
#6
Nae Yu Kim, Jin Hwa Kim, Jung-Soo Pyo, Won Jin Cho
INTRODUCTION: A meta-analysis was done to investigate the clinicopathological significance of the loss of p27kip1 expression in papillary thyroid carcinoma (PTC). METHODS: The meta-analysis involving 17 studies included 1,652 PTC and 328 benign cases. The rate of p27kip1 expression loss in PTC and benign lesions, and the correlations between p27kip1 expression loss and clinicopathological characteristics of PTC were determined. RESULTS: The estimated rate of p27kip1 expression loss was 0...
November 5, 2016: International Journal of Biological Markers
https://www.readbyqxmd.com/read/27833153/tert-promoter-mutation-and-its-association-with-clinicopathological-features-and-prognosis-of-papillary-thyroid-cancer-a-meta-analysis
#7
Chunping Liu, Zeming Liu, Tianwen Chen, Wen Zeng, Yawen Guo, Tao Huang
We performed a meta-analysis to elucidate the associations of the clinicopathological characteristics and prognostic factors of papillary thyroid cancer (PTC) with TERT promoter mutations. A literature search was performed of the PubMed and EMBASE databases using Medical Subject Headings and keywords. Individual study-specific odds ratios (ORs) and confidence intervals (CIs) were calculated. The average prevalence rate of TERT promoter mutations was 10.1%. TERT promoter mutations occurred more frequently in patients with larger tumors (p = 0...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27832644/comparing-the-diagnostic-accuracy-of-rte-and-swe-in-differentiating-malignant-thyroid-nodules-from-benign-ones-a-meta-analysis
#8
Wuguo Tian, Shuai Hao, Bo Gao, Yan Jiang, Xiaohua Zhang, Shu Zhang, Lingji Guo, Jie Yan, Donglin Luo
BACKGROUND: Approximately 10-20 million Americans have been clinically diagnosed with thyroid nodules. Shear wave elastography (SWE) and real-time elastography (RTE) are two primary forms of elastography for identifying the status of thyroid nodules. The aim of this study is to assess the performance of RTE and SWE in identifying malignant thyroid nodules. METHODS: Relevant articles were systematically retrieved from PubMed, Embase and Cochrane Library. In order to evaluate the overall diagnostic accuracy, we have considered pooled sensitivity (SEN), specificity (SPE), area under the curve (AUC) and partial AUC with corresponding 95% confidence intervals (95%CIs)...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27806973/neonatal-thyrotropin-concentration-and-iodine-nutrition-status-of-mothers-a-systematic-review-and-meta-analysis
#9
Pantea Nazeri, Parvin Mirmiran, Ali Kabir, Fereidoun Azizi
BACKGROUND: Low maternal iodine intake disturbs the thyroid function of neonates transiently or permanently. OBJECTIVE: To our knowledge, we conducted one of the first systematic reviews and meta-analyses aimed at exploring the association of neonatal thyrotropin concentrations and iodine status of mothers during pregnancy and early postpartum periods. DESIGN: Data were collected through literature searches for studies published between 1969 and 2015 with the use of electronic databases...
November 2, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27803869/alcohol-consumption-and-dry-eye-syndrome-a-meta-analysis
#10
Yong-Sheng You, Nai-Bin Qu, Xiao-Ning Yu
AIM: To quantify the association between alcohol consumption and dry eye syndrome (DES) with Meta-analysis of published case-control and cross-sectional studies. METHODS: Three databases were screened for potentially eligible studies through Nov. 30, 2015, PubMed, Web of Science, and the Cochrane Library. Odds ratios (ORs) were pooled with 95% confidence intervals (CIs) to evaluate the relationship between alcohol consumption and DES risk. Subgroup analyses were performed according to diagnostic criteria, publication year, sample size, alcohol intake and adjusted factors...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27797976/genomic-heterogeneity-and-exceptional-response-to-dual-pathway-inhibition-in-anaplastic-thyroid-cancer
#11
William J Gibson, Daniel T Ruan, Vera A Paulson, Justine A Barletta, Glenn J Hanna, Stefan Kraft, Antonio Calles, Matthew A Nehs, Francis D Moore, Amaro Taylor-Weiner, Jeremiah A Wala, Travis I Zack, Thomas C Lee, Fiona M Fennessy, Erik K Alexander, Tom Tomas, Pasi A Janne, Levi A Garraway, Scott L Carter, Rameen Beroukhim, Jochen H Lorch, Eliezer Van Allen
PURPOSE: Cancers may resist single-agent targeted therapies when the flux of cellular growth signals is shifted from one pathway to another. Blockade of multiple pathways may be necessary for effective inhibition of tumor growth. We document a case in which a patient with anaplastic thyroid carcinoma (ATC) failed to respond to either mTOR or combined RAF/MEK inhibition, but experienced a dramatic response when both drug regimens were combined. EXPERIMENTAL DESIGN: Multi-region whole-exome sequencing of five diagnostic and four autopsy tumor biopsies was performed...
October 17, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27797226/association-between-pax8-pparandgamma-1-rearrangement-and-follicular-thyroid-cancer-a-meta-analysis
#12
Hang-Yu Li, Zhi-Hao Xie, Cong-Hui Xu, Mei-Ling Pu, Zi-Yan Chen, Miao Yu, Heng-Shu Wang, Chen-Ming Zhou, Chao-Yu Pu, Wei Liu
BACKGROUND: Pax8 and peroxisome proliferator-activated receptor gamma 1 gene (Pax8-PPARγ1) are important factors in tumors. Several studies have suggested that follicular thyroid cancer may arise from Pax8- PPArγ1 rearrangement. In order to have a better understanding of the association between Pax8-PPARγ1 rearrangement and follicular thyroid cancer, we conducted the presenmt meta-analysis. MATERIALS AND METHODS: The information was extracted from PubMed, EMBASE and Web of Science...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27790248/large-scale-gene-expression-meta-analysis-reveals-tissue-specific-sex-biased-gene-expression-in-humans
#13
Benjamin T Mayne, Tina Bianco-Miotto, Sam Buckberry, James Breen, Vicki Clifton, Cheryl Shoubridge, Claire T Roberts
The severity and prevalence of many diseases are known to differ between the sexes. Organ specific sex-biased gene expression may underpin these and other sexually dimorphic traits. To further our understanding of sex differences in transcriptional regulation, we performed meta-analyses of sex biased gene expression in multiple human tissues. We analyzed 22 publicly available human gene expression microarray data sets including over 2500 samples from 15 different tissues and 9 different organs. Briefly, by using an inverse-variance method we determined the effect size difference of gene expression between males and females...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27789450/performance-of-ct-in-the-preoperative-diagnosis-of-cervical-lymph-node-metastasis-in-patients-with-papillary-thyroid-cancer-a-systematic-review-and-meta-analysis
#14
C H Suh, J H Baek, Y J Choi, J H Lee
BACKGROUND AND PURPOSE: Ultrasound has become widely accepted as the first imaging technique used for the assessment of cervical lymph node metastasis in patients with papillary thyroid cancer. In this systematic review and meta-analysis, we evaluate the performance of CT for the preoperative diagnosis of cervical lymph node metastasis in patients with papillary thyroid cancer compared with ultrasound. MATERIALS AND METHODS: Ovid-MEDLINE and EMBASE data bases were searched for studies regarding the use of CT to diagnose cervical lymph node metastasis...
October 27, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27784343/patterns-of-association-of-chronic-medical-conditions-and-major-depression
#15
S B Patten, J V A Williams, D H Lavorato, J L Wang, N Jetté, T T Sajobi, K M Fiest, A G M Bulloch
AIMS: Age and sex-related patterns of association between medical conditions and major depressive episodes (MDE) are important for understanding disease burden, anticipating clinical needs and for formulating etiological hypotheses. General population estimates are especially valuable because they are not distorted by help-seeking behaviours. However, even large population surveys often deliver inadequate precision to adequately describe such patterns. In this study, data from a set of national surveys were pooled to increase precision, supporting more precise characterisation of these associations...
October 27, 2016: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/27780830/can-we-predict-relapse-in-graves-disease-results-from-a-systematic-review-and-meta-analysis
#16
Tristan Struja, Hannah Fehlberg, Alexander Kutz, Larissa Guebelin, Christian Degen, Beat Muller, Philipp Schuetz
BACKGROUND: Identification of pre-treatment risk factors predicting relapse in patients with hyperthyroidism of Graves' disease after stopping anti-thyroid drugs [ATD] is decisive to guide therapeutic options. PURPOSE: We performed a systematic search and meta-analysis to study predictors for relapse after stopping ATD in patients with Graves' disease. METHODS: Based on a pre-specified protocol, we searched PubMed, EMBASE and Cochrane in July 2015 for case-control, controlled, and randomized-controlled trials reporting risk factors for relapse after stopping ATD...
October 25, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27776249/non-thyroidal-illness-syndrome-in-patients-with-cardiovascular-diseases-a-systematic-review-and-meta-analysis
#17
Bin Wang, Suijun Liu, Ling Li, Qiuming Yao, Ronghua Song, Xiaoqing Shao, Qian Li, Xiaohong Shi, Jin-An Zhang
BACKGROUND: Non-thyroidal illness syndrome (NTIS) is characterized by decreased serum triiodothyronine level without increased thyroid-stimulating hormone level during critical illness. The summary data on the prevalence of NTIS in cardiovascular patients are lacking, and its prognostic role in cardiovascular patients is also unclear. METHODS: We performed a systematic review and meta-analysis to comprehensively determine the prevalence and the prognostic role of NTIS in cardiovascular patients...
January 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27756889/a-meta-analysis-on-the-effect-of-operation-modes-on-the-recurrence-of-papillary-thyroid-microcarcinoma
#18
Dandan Yi, Peng Song, Tao Huang, Xiaoqiao Tang, Jianfeng Sang
Whether total thyroidectomy reduces the recurrence rate in patients with papillary thyroid microcarcinoma (PTMC) is currently controversy. Conclusions of sporadic, inconsistent, and mono-institutional studies need a meta-analysis to evaluate. 525 relevant studies were obtained from initial search on PubMed, 511 studies were excluded by inclusion and exclusion criteria. Eligible data were extracted from each included study. The Odds ratios (ORs) and 95% confidence interval (CI) were used to assess the difference in the recurrence rates between PTMC patients treated with total thyroidectomy and non-total thyroidectomy...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27717596/inositol-as-putative-integrative-treatment-for-pcos
#19
REVIEW
Alessandro D Genazzani
Studies over the last decade have demonstrated that some polycystic ovary syndrome (PCOS) patients have abnormal insulin sensitivity (insulin resistance), independently from being overweight or obese. This induces the risk of developing type 2 diabetes in such PCOS patients. The use of insulin sensitizers (i.e. metformin), reduces such metabolic, and most hormonal, impairments. As metformin often induces side effects, new integrative strategies have been proposed to treat insulin resistance, such as the use of inositols...
September 16, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27702392/selenium-supplementation-significantly-reduces-thyroid-autoantibody-levels-in-patients-with-chronic-autoimmune-thyroiditis-a-systematic-review-and-meta-analysis
#20
Johanna Wichman, Kristian Hillert Winther, Steen Joop Bonnema, Laszlo Hegedus
BACKGROUND: Selenium supplementation may decrease circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT), but the previous trials are heterogenous. Here, we expand and critically reappraise the knowledge on this topic. METHODS: A literature search identified 3366 records. Controlled trials in adults (≥ 18 years) with AIT, comparing selenium with or without levothyroxine (LT4), versus placebo and/or LT4, were eligible. Assessed outcomes were serum thyroid peroxidase (TPO-Ab), thyroglobulin (Tg-Ab) autoantibody levels, and immunomodulatory effects...
October 5, 2016: Thyroid: Official Journal of the American Thyroid Association
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