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thyroid AND meta-analysis

Alessandro D Genazzani
Studies over the last decade have demonstrated that some polycystic ovary syndrome (PCOS) patients have abnormal insulin sensitivity (insulin resistance), independently from being overweight or obese. This induces the risk of developing type 2 diabetes in such PCOS patients. The use of insulin sensitizers (i.e. metformin), reduces such metabolic, and most hormonal, impairments. As metformin often induces side effects, new integrative strategies have been proposed to treat insulin resistance, such as the use of inositols...
September 16, 2016: Reproductive Biomedicine Online
Johanna Wichman, Kristian Hillert Winther, Steen Joop Bonnema, Laszlo Hegedus
BACKGROUND: Selenium supplementation may decrease circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT), but the previous trials are heterogenous. Here, we expand and critically reappraise the knowledge on this topic. METHODS: A literature search identified 3366 records. Controlled trials in adults (≥ 18 years) with AIT, comparing selenium with or without levothyroxine (LT4), versus placebo and/or LT4, were eligible. Assessed outcomes were serum thyroid peroxidase (TPO-Ab), thyroglobulin (Tg-Ab) autoantibody levels, and immunomodulatory effects...
October 5, 2016: Thyroid: Official Journal of the American Thyroid Association
Carole Rieben, Daniel Segna, Bruno R da Costa, Tinh-Hai Collet, Layal Chaker, Carole E Aubert, Christine Baumgartner, Osvaldo P Almeida, Eef Hogervorst, Stella Trompet, Kamal Masaki, Simon P Mooijaart, Jacobijn Gussekloo, Robin P Peeters, Douglas C Bauer, Drahomir Aujesky, Nicolas Rodondi
CONTEXT: While both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting. OBJECTIVE: To determine the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction among prospective cohorts. DATA SOURCES: Search in MEDLINE, EMBASE until November 2014. STUDY SELECTION: Two physicians identified prospective cohorts that assessed thyroid function and cognitive outcomes (dementia; Mini-Mental State Examination, MMSE)...
September 30, 2016: Journal of Clinical Endocrinology and Metabolism
Elliot A Krauss, Megan Mahon, Jean M Fede, Lanjing Zhang
CONTEXT: -Fine-needle aspiration (FNA) biopsies have been an important component in the preoperative evaluation of thyroid nodules. Until the introduction of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) in 2008, individual institutions had developed their own diagnostic categories. The BSRTC proposed 6 categories in an attempt to standardize reporting of thyroid FNA. OBJECTIVE: -To present a 15-year experience of thyroid FNA at one institution, including data before and after introduction of the BSRTC...
October 2016: Archives of Pathology & Laboratory Medicine
Kristian Hillert Winther, Johanna Eva Märta Wichman, Steen Joop Bonnema, Laszlo Hegedüs
By a systematic review and meta-analysis to investigate clinically relevant effects of selenium supplementation in patients with chronic autoimmune thyroiditis. Controlled trials in adults (≥18 years) with autoimmune thyroiditis, comparing selenium with or without levothyroxine substitution, versus placebo and/or levothyroxine substitution, were eligible for inclusion. Identified outcomes were serum thyrotropin (thyroid stimulating hormone) levels in LT4-untreated patients, thyroid ultrasound and health-related quality of life...
September 28, 2016: Endocrine
Sudha Arumugam, Christine Sm Lau, Ronald S Chamberlain
OBJECTIVES: Effective postoperative pain management is crucial in the care of surgical patients. Opioids, which are commonly used in managing postoperative pain, have a potential for tolerance and addiction, along with sedating side effects. Gabapentin's use as a multimodal analgesic regimen to treat neuropathic pain has been documented as having favorable side effects. This meta-analysis examined the use of preoperative gabapentin and its impact on postoperative opioid consumption. MATERIALS AND METHODS: A comprehensive literature search was conducted to identify randomized control trials that evaluated preoperative gabapentin on postoperative opioid consumption...
2016: Journal of Pain Research
Andrea Busnelli, Alessio Paffoni, Luigi Fedele, Edgardo Somigliana
No abstract text is available yet for this article.
September 26, 2016: Human Reproduction Update
Liang-Sen Liu, Jia Liang, Jun-Hong Li, Xue Liu, Li Jiang, Jian-Xiong Long, Yue-Ming Jiang, Zhi-Xiao Wei
Although there have been many studies identifying clinical and pathologic factors that may predict central lymph node metastases (CLNM) in papillary thyroid microcarcinoma (PTMC) patients without clinically cervical lymph node metastasis (cN0), the results were inconsistent. And whether prophylactic central lymph node dissection (pCLND) should be performed in cN0 PTMC remains controversial. The EMBASE, PubMed, MEDLINE and the Cochrane Library were searched until Oct 2015 to identify relevant studies. Primary outcomes were clinical and pathologic factors for CLNM...
September 19, 2016: European Archives of Oto-rhino-laryngology
Abhishek Phatarphekar, Steven E Rokita
The flavoprotein iodotyrosine deiodinase (IYD) was first discovered in mammals through its ability to salvage iodide from mono- and diiodotyrosine, the by-products of thyroid hormone synthesis. Genomic information indicates that invertebrates contain homologous enzymes although their iodide requirements are unknown. The catalytic domain of IYD from Drosophila melanogaster has now been cloned, expressed and characterized to determine the scope of its potential catalytic function as a model for organisms that are not associated with thyroid hormone production...
September 19, 2016: Protein Science: a Publication of the Protein Society
Trine Grantzau, Jens Overgaard
BACKGROUND AND PURPOSE: Radiotherapy plays an essential role in early breast cancer treatment, but is also associated with an increased risk of second malignancies decades after the exposure. MATERIALS AND METHODS: We systematically searched the data-bases Medline/Pubmed, Cochrane, Embase, and Cinahl, for cohort studies estimating the risk of second non-breast cancer after primary breast cancer. Every included study was to report the standardized incidence ratio [SIR] of second cancers, comparing the risk among either irradiated or unirradiated female breast cancer patients to the risk of the general female population...
September 14, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Brandon Michael Henry, Jens Vikse, Matthew J Graves, Silvia Sanna, Beatrice Sanna, Iwona M Tomaszewska, Wan Chin Hsieh, R Shane Tubbs, Krzysztof A Tomaszewski
BACKGROUND: The relationship between the recurrent laryngeal nerve (RLN) and inferior thyroid artery (ITA) is highly variable and traceable back to embryological life. METHODS: Comprehensive database searches were conducted, followed by judgment of eligibility, assessment, and extraction of data concerning the RLN/ITA relationship. The data were pooled into a meta-analysis and subjected to sex, side-based, geographic origin of study, and study modality subgroup analyses...
September 14, 2016: Head & Neck
Weifeng Shang, Liu Huang, Li Li, Xiaojuan Li, Rui Zeng, Shuwang Ge, Gang Xu
It has been reported that patients receiving renal replacement therapy (RRT), including dialysis and kidney transplantation, tend to have an increased risk of cancer; however, studies on the degree of this risk have remained inconclusive. The present meta-analysis was therefore performed to quantify the cancer risk in patients with RRT. Cohort studies assessing overall cancer risk in RRT patients published before May 29, 2015 were included following systematic searches with of PubMed, EMBASE and the reference lists of the studies retrieved...
September 2016: Molecular and Clinical Oncology
Luis Furuya-Kanamori, Katy J L Bell, Justin Clark, Paul Glasziou, Suhail A R Doi
PURPOSE: Differentiated thyroid cancer (DTC) incidence has been reported to have increased three- to 15-fold in the past few decades. It is unclear whether this represents overdiagnosis or a true increase in incidence. Therefore, the current study aimed to estimate the prevalence of incidental DTC in published autopsy series and determine whether this prevalence has been increasing over time. MATERIALS AND METHODS: PubMed, Embase, and Web of Science were searched from inception to December 2015 for relevant studies...
September 6, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Chunping Liu, Tianwen Chen, Zeming Liu
BACKGROUND: The objective of this study is to perform a meta-analysis to evaluate the associations between the BRAF(V600E) mutation status and aggressive clinicopathological features and poor prognostic factors in papillary thyroid cancer. METHODS: A literature search was performed within the PubMed, MEDLINE, Web of Science databases, and EMBASE databases using the Medical Subject Headings and keywords from January 2003 to July 2015. Individual study-specific odds ratios and confidence intervals were calculated, as were the Mantel-Haenszel pooled odds ratios for the combined studies...
2016: World Journal of Surgical Oncology
Hong Xu, Nele Brusselaers, Bengt Lindholm, Carmine Zoccali, Juan Jesús Carrero
BACKGROUND: We evaluated current evidence associating thyroid function test result derangements with risk for mortality in patients with chronic kidney failure treated by long-term dialysis. STUDY DESIGN: Systematic review and meta-analysis of cohort studies. SETTING & POPULATION: Dialysis patients. SELECTION CRITERIA FOR STUDIES: We searched PubMed, Web of Science, Science Citation Index, Cochrane Library, and Embase databases from inception through December 2015...
September 2, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Sunghwan Suh, Kyoungjune Pak, Ju Won Seok, In Joo Kim
PURPOSE: Thyroid cancer is the most common endocrine cancer and its incidence has continuously increased in the last three decades all over the world. We aimed to evaluate the prognostic value of extranodal extension (ENE) of thyroid cancer. MATERIALS AND METHODS: We performed a systematic search of MEDLINE (from inception to June 2014) and EMBASE (from inception to June 2014) for English-language publication. The inclusion criteria were studies of thyroid cancer that reported the prognostic value of ENE in thyroid cancer...
November 2016: Yonsei Medical Journal
Celestino Pio Lombardi, Giulia Carnassale, Gianfranco Damiani, Anna Acampora, Marco Raffaelli, Carmela De Crea, Rocco Bellantone
BACKGROUND: The aim of our research was to explore the specific role of intermittent intraoperative neuromonitoring (IONM) versus visualization alone in preventing permanent nerve palsy in thyroid surgery. METHODS: A systematic review was conducted by searching electronic databases using specific keywords and completed by hand search. The article selection process was carried out by 2 independent investigators using well-defined inclusion and exclusion criteria...
August 24, 2016: Surgery
Fen Chen, Guo Tian, Dexing Kong, Liyun Zhong, Tian'an Jiang
BACKGROUND: Thyroid nodules (TNs) usually appearing in the general population have the potential possibility of malignant transformation and common problems of jugular oppression such as dyspnea and hoarseness. We performed this meta-analysis to evaluate the efficiency of radiofrequency ablation (RFA) for the treatment of benign TNs in accord with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements. METHODS: Published literatures were retrieved from PubMed, Embase, Web of Science, and Scopus up to January 27, 2016...
August 2016: Medicine (Baltimore)
Yue Wu, Yuqing Pei, Fei Wang, Danfei Xu, Wei Cui
Observational studies of thyroid function and dementia have reported conflicting results. We reviewed cohort and case-control studies from MEDLINE, EMBASE, Web of Science and the Cochrane Library that focused on the association between serum thyroxine, thyrotropin and dementia. A total of 24,952 participants from three case-control and eight cohort studies were included. The relationships between dementia and the per standard deviation (SD) increment of free thyroxine (FT4) (random relative ratio (RR) = 1...
2016: Scientific Reports
Sirshak Dutta, Kaustuv Das Biswas, Soumya Ghatak, Dibakar Haldar, Indranil Sen, Ramanuj Sinha
Primary laryngeal carcinoma is a common cancer, predominantly affecting males. Hypothyroidism is an undesirable sequela of both surgery and radiotherapy, the two most commonly used modalities of treatment. For advanced cases, standard treatment protocol includes total laryngectomy and neck dissection along with pre- or postoperative radiotherapy. Hemithyroidectomy is also routinely performed as an integral part of total laryngectomy. In the present study, assessment of the function of the remaining half of the thyroid gland has been done in cases of total laryngectomies in combination with uni- or bilateral neck dissection and pre- or postoperative radiotherapy...
August 2016: Ear, Nose, & Throat Journal
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