Ling Chen, Ye Lu, Yi-Fan Zhou, Yang Wang, Hai-Feng Zhan, Yu-Ting Zhao, Yu-Lu Wang, Fei-Fei Zhang, Hang Chen, Xin Li
BACKGROUND AND OBJECTIVE: Weight loss-related amenorrhea is defined as the reversible functional inhibition of the hypothalamic-pituitary-ovarian (HPO) axis associated with weight loss or low body weight, which occurs mostly in adolescents and women of reproductive age. The specific pathological mechanisms of this disease have not yet been elucidated, and the optimal evidence-based guidelines for its clinical assessment and management are limited. This review summarizes its adverse effects on female health, and the individualized, emerging, and multidisciplinary therapeutic approaches used to treat it...
January 31, 2023: Annals of Translational Medicine