keyword
https://read.qxmd.com/read/37768821/herlyn-werner-wunderlich-syndrome-a-fertility-sparing-approach-to-a-rare-mullerian-anomaly
#21
Gabriela Palhano Sifuentes Melo, Thamires Furley Moreira Jandre, Anna Laura Rocha Hermes Vilardo, Roberto de Azevedo Antunes, Daniella Braz Parente, Afrânio Coelho-Oliveira
The Herlyn-Werner-Wunderlich syndrome (HWWS) is characterized by the triad of uterus didelphys, obstructed hemivagina, and renal agenesis. The typical clinical presentation involves chronic pelvic pain, dysmenorrhea, and palpable abdominal mass, related to hematocolpos/hematometra. It is a rare disease, with a challenging clinical and radiological diagnosis. Surgery is the definitive treatment. Complications such as endometriosis, infertility and chronic pelvic pain occur more frequently and severely when diagnosis and treatment are delayed...
September 28, 2023: JBRA Assisted Reproduction
https://read.qxmd.com/read/37736597/polycystic-ovary-syndrome-due-to-the-novel-translocation-46xx-t-2-9-q21-p24
#22
Josef Finsterer
The etiology of polycystic ovary syndrome (PCOS) is not exactly known, but there are indications that genetic factors, exposure to androgen in early childhood, and obesity lead to a disruption of the hypothalamic-pituitary-ovarian axis and dysregulation of microRNAs. Chromosomal aberrations have rarely been described as a cause of PCOS. We present the case of a 20-year-old female diagnosed with PCOS at age 17 due to hyperandrogenism, obesity, polycystic ovaries, amenorrhoea, and emerging insulin resistance...
2023: Archive of clinical cases
https://read.qxmd.com/read/37734917/the-impact-of-diabetes-and-obesity-on-fertility-and-the-potential-role-of-gut-hormones-as-treatment
#23
REVIEW
Ananyaa Sridhar, Dawood Khan, Charlotte R Moffett
Obesity poses an enormous threat to life expectancy and quality of life in people with associated metabolic comorbidities. Alongside its metabolic implications, obesity and associated diabetes impair female reproductive function, causing infertility and polycystic ovarian syndrome (PCOS). Recently, gut hormones and their receptors have been identified in various reproductive organs indicating their potential regulatory effects on reproductive function. This review focuses on modifications during obesity, diabetes and related infertility with an emphasis on gut hormones and their therapeutic potential...
September 21, 2023: Diabetic Medicine: a Journal of the British Diabetic Association
https://read.qxmd.com/read/37704445/prophylactic-effects-of-hemp-seed-oil-on-perimenopausal-depression-a-role-of-hpa-axis
#24
JOURNAL ARTICLE
Jiao Ma, Chen-Yang Guo, Han-Bing Li, Su-Hui Wu, Gen-Lin Li
Hemp seed, the dried fruit of Cannabis sativa L. (Moraceae), has been extensively documented as a folk source of food due to its nutritional and functional value. This study evaluated the antidepressant effect of hemp seed oil (HSO) during its estrogen-like effect in Perimenopausal depression (PMD) rats induced by ovariectomy combined with chronic unpredictable mild stress (OVX-CUMS). Female SD rats (SPF, 10 weeks, sham operated group, ovariectomy (OVX) model group, ovariectomy - chronic unpredictable mild stress (OVX-CUMS) group, HSO + OVX-CUMS group, fluoxetine (FLU) + OVX-CUMS group, n=8) were subjected to treatment with HSO (4...
September 12, 2023: Journal of Oleo Science
https://read.qxmd.com/read/37629254/aberrant-hpo-axis-alterations-and-autoimmune-abnormalities-in-pcos-patients-with-dor-a-retrospective-analysis
#25
JOURNAL ARTICLE
Xueying Geng, Zhihong He, Zhouzhou Bao, Wen Di, Zhuowei Gu
BACKGROUND: There is a group of polycystic ovary syndrome (PCOS) patients in clinic who have diminished ovarian reserve (DOR) in combination. This study was designed to evaluate the differences in glucolipid metabolism, hypothalamic-pituitary-ovarian (HPO) axis-related parameters, and autoimmune antibodies in PCOS patients with and without DOR. METHODS: A total of 2307 PCOS patients, including 1757 patients with PCOS alone and 550 patients who have both PCOS and DOR, were enrolled in this retrospective study...
August 10, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37452264/potential-for-npy-receptor-related-therapies-for-polycystic-ovary-syndrome-an-updated-review
#26
REVIEW
Wei-Hong Chen, Yan-Chuan Shi, Qiao-Yi Huang, Jia-Ming Chen, Zhi-Yi Wang, Shu Lin, Qi-Yang Shi
Polycystic ovary syndrome (PCOS) is a complex endocrine disease that can cause female infertility and bring economic burden to families and to society. The clinical and/or biochemical manifestations include hyperandrogenism, persistent anovulation, and polycystic ovarian changes, often accompanied by insulin resistance and obesity. Although its pathogenesis is unclear, PCOS involves the abnormal regulation of the hypothalamic-pituitary-ovarian axis and the abnormal activation of GnRH neurons. Neuropeptide Y (NPY) is widely distributed in the arcuate nucleus of the hypothalamus and functions as the physiological integrator of two neuroendocrine systems, one governing feeding and the other controlling reproduction...
July 14, 2023: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/37432488/effect-of-high-fat-diet-on-disease-development-of-polycystic-ovary-syndrome-and-lifestyle-intervention-strategies
#27
REVIEW
Yingxue Han, Hao Wu, Siyuan Sun, Rong Zhao, Yifan Deng, Shenming Zeng, Juan Chen
Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder that affects premenopausal women. The etiology of PCOS is multifaceted, involving various genetic and epigenetic factors, hypothalamic-pituitary-ovarian dysfunction, androgen excess, insulin resistance, and adipose-related mechanisms. High-fat diets (HFDs) has been linked to the development of metabolic disorders and weight gain, exacerbating obesity and impairing the function of the hypothalamic-pituitary-ovarian axis. This results in increased insulin resistance, hyperinsulinemia, and the release of inflammatory adipokines, leading to heightened fat synthesis and reduced fat breakdown, thereby worsening the metabolic and reproductive consequences of PCOS...
May 8, 2023: Nutrients
https://read.qxmd.com/read/37428803/sirt1-and-antioxidants-in-infertile-females-exploration-of-the-role-of-vitamin-d
#28
JOURNAL ARTICLE
Faiza Alam, Maheen Shahid, Sumaira Riffat, Ihsan Nazurah Zulkipli, Fatima Syed, Mussarat Ashraf, Rehana Rehman
BACKGROUND: Deficiency of silent information regulator 1 (SIRT1) can trigger inflammation, mitochondrial malfunctioning, and apoptosis through the hypothalamic-pituitary-ovarian axis, producing poor quality oocytes, leading to infertility. Normal vitamin D (VD) levels promote SIRT1 activity required for optimal fertility, and low levels of either may result in fertility problems owing to cell-membrane de-stabilization, increased autophagy, DNA damage leading to increased reactive oxygen species and mitochondrial dysfunction...
2023: PloS One
https://read.qxmd.com/read/37282955/-mechanism-of-tonifying-kidney-and-activating-blood-therapy-for-premature-ovarian-failure-a-review
#29
REVIEW
Kun Ma, Jia-Ni Li, Xiao-di Fan, Han Zhang, Lin-Na Ma
Healthy birth and child development are the prerequisite for improving the overall quality of the population. However, premature ovarian failure(POF) threatens the reproductive health of women. The incidence of this disease has been on the rise, and it tends to occur in the young. The causes are complex, involving genetics, autoimmune, infectious and iatrogenic factors, but most of the causes remain unclear. At the moment, hormone replacement therapy and assisted reproductive technology are the main clinical approaches...
April 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/37198672/correction-polycystic-ovary-rat-model-exposure-to-150%C3%A2-khz-intermediate-frequency-hypothalamic-pituitary-ovarian-axis-at-the-receptor-cellular-tissue-and-hormone-levels
#30
Stephanie Mohammed, Venkatesan Sundaram, Chalapathi R Adidam Venkata, Nikolay Zyuzikov
No abstract text is available yet for this article.
May 17, 2023: Journal of Ovarian Research
https://read.qxmd.com/read/37126206/immunohistochemistry-of-leukemia-inhibitory-factor-and-integrin-%C3%AE-v%C3%AE-3-in-mouse-endometrium-following-kisspeptin-54-ovulation-trigger
#31
JOURNAL ARTICLE
Amr O Abdelkareem, Mahmoud S Iews, Abdou S Ait-Allah, Salah M Rasheed, Yasser A Helmy, Ruth Habte, Faten F Abdelhafez, Mohamed A Bedaiwy
Kisspeptin (KP) is a group of hypothalamic neuropeptides encoded by KISS-1 gene. KP-54, a 54-amino-acid peptide, helps regulate the hypothalamic-pituitary-ovarian axis and plays a potential role in implantation. C57BL/6 J female mice were superovulated via intraperitoneal injection of 5 International Units (IU) pregnant mare serum gonadotrophin (day 1). Forty-eight hours later, mice (5/group) were injected with phosphate-buffered saline (PBS) (group A), 5 IU human chorionic gonadotrophin (hCG) (group B), or 3 nmol KP-54 (group C)...
May 1, 2023: Reproductive Sciences
https://read.qxmd.com/read/37112528/effects-of-decamethylcyclopentasiloxane-on-reproductive-systems-in-female-rats
#32
JOURNAL ARTICLE
Jimin Lee, Kangmin Kim, Seon-Mi Park, Jin-Sook Kwon, Eui-Bae Jeung
The female reproductive system becomes fertile through the action of hormones involved in the hypothalamic-pituitary-ovarian axis. On the other hand, estrogen-like endocrine disruptors released into the environment come into contact with humans by various routes and affect the reproductive system. Exposure to these chemicals can cause problems with the reproductive process, from egg ovulation to implantation, or cause female reproductive diseases. These reproductive problems cause infertility. Decamethylcyclopentasiloxane (D5) is used for lubrication in silicone polymers, households, and personal care products...
March 25, 2023: Toxics
https://read.qxmd.com/read/37082665/diane-35-and-metformin-therapy-in-rats-with-endometrial-lesions-induced-by-dihydrotestosterone-exposure
#33
JOURNAL ARTICLE
Yanjun Liu, Ran Xu, Yifan Zhou, Yang Wang, Feifei Zhang, Xiaoyu Tong, Peng Cui, Tong Ma, Jian Sun, Yi Feng, Xin Li
BACKGROUND: Cotreatment with metformin and Diane-35 is conventionally used in the clinic to ameliorate ovulatory dysfunction and insulin resistance in women with polycystic ovary syndrome (PCOS). We previously showed that this combination treatment could reverse endometrial hyperplasia and endometrial cancer (EC) in patients with PCOS. Here, we aimed to investigate the influence of dihydrotestosterone (DHT) and this cotreatment on the endometrium, along with the related mechanisms. METHODS: We treated a DHT-exposed rat model with Diane-35 or metformin alone or their combination and investigated the 3-dimensional (3D) endometrial structure to determine the role of these treatments in reversing endometrial lesions and to clarify the underlying mechanisms...
March 31, 2023: Annals of Translational Medicine
https://read.qxmd.com/read/37024976/mechanisms-of-ovarian-aging-in-women-a-review
#34
REVIEW
Xiangfei Wang, Lingjuan Wang, Wenpei Xiang
Ovarian aging is a natural and physiological aging process characterized by loss of quantity and quality of oocyte or follicular pool. As it is generally accepted that women are born with a finite follicle pool that will go through constant decline without renewing, which, together with decreased oocyte quality, makes a severe situation for women who is of advanced age but desperate for a healthy baby. The aim of our review was to investigate mechanisms leading to ovarian aging by discussing both extra- and intra- ovarian factors and to identify genetic characteristics of ovarian aging...
April 6, 2023: Journal of Ovarian Research
https://read.qxmd.com/read/36933953/polycystic-ovary-syndrome-and-related-inflammation-in-radiomics-relationship-with-patient-outcome
#35
REVIEW
Chun-Yang Zheng, Yue-Xin Yu, Xue Bai
Polycystic ovary syndrome (PCOS) refers to a condition that often has 'poly' liquid containing sacks around ovaries. It affects reproductive-aged females giving rise to menstrual and related reproductive issues. PCOS is marked by hormonal imbalance often resulting in hyperandrogenism. Inflammation is now considered a central manifestation of this disease with several inflammatory biomarkers such as TNF-α, C-reactive protein and Interleukins-6/18 found to be particularly elevated in PCOS patients. Diagnosis is often late, and MRI-based diagnosis, along with blood-based analyses, are still the best bet for a definitive diagnosis...
March 16, 2023: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/36899465/genital-epithelial-barrier-function-is-conserved-by-intravaginal-rings-releasing-etonogestrel-and-ethinyl-estradiol
#36
JOURNAL ARTICLE
Mohan Liu, Rodolfo D Vicetti Miguel, Nirk E Quispe Calla, Kristen M Aceves, Linda Fritts, Christopher J Miller, John A Moss, Marc M Baum, Thomas L Cherpes
The injectable progestin depot-medroxyprogesterone acetate (DMPA) is a popular contraceptive choice in sub-Saharan Africa although mouse models indicate it weakens genital epithelial integrity and barrier function and increases susceptibility to genital infection. The intravaginal ring NuvaRing® is another contraceptive option that like DMPA suppresses hypothalamic pituitary ovarian (HPO) axis function with local release of progestin (etonogestrel) and estrogen (ethinyl estradiol). As we previously reported that treating mice with DMPA and estrogen averts the loss of genital epithelial integrity and barrier function induced by DMPA alone, in the current investigation we compared genital levels of the cell-cell adhesion molecule desmoglein-1 (DSG1) and genital epithelial permeability in rhesus macaques (RM) treated with DMPA or a NuvaRing®re-sized for RM (N-IVR)...
March 10, 2023: Tissue Barriers
https://read.qxmd.com/read/36860674/role-of-obesity-in-female-reproduction
#37
REVIEW
Wei Yong, Jiajia Wang, Yan Leng, Lijie Li, Han Wang
Contemporary scientists need no "p value" and "relative risk" statistics to be exquisitely aware of the increasing prevalence of obesity and complications posed by obesity. It is now well recognized that obesity is strongly associated with type 2 diabetes, hypertension, vascular disease, tumors and reproductive disorders. Obese women show lower levels of gonadotropin hormones, reduced fecundity, higher miscarriage rates and poorer outcomes of in vitro fertilization, revealing that obesity affects female reproduction...
2023: International Journal of Medical Sciences
https://read.qxmd.com/read/36819572/the-effects-of-weight-loss-related-amenorrhea-on-women-s-health-and-the-therapeutic-approaches-a-narrative-review
#38
REVIEW
Ling Chen, Ye Lu, Yi-Fan Zhou, Yang Wang, Hai-Feng Zhan, Yu-Ting Zhao, Yu-Lu Wang, Fei-Fei Zhang, Hang Chen, Xin Li
BACKGROUND AND OBJECTIVE: Weight loss-related amenorrhea is defined as the reversible functional inhibition of the hypothalamic-pituitary-ovarian (HPO) axis associated with weight loss or low body weight, which occurs mostly in adolescents and women of reproductive age. The specific pathological mechanisms of this disease have not yet been elucidated, and the optimal evidence-based guidelines for its clinical assessment and management are limited. This review summarizes its adverse effects on female health, and the individualized, emerging, and multidisciplinary therapeutic approaches used to treat it...
January 31, 2023: Annals of Translational Medicine
https://read.qxmd.com/read/36747683/loss-of-genital-epithelial-barrier-function-is-greater-with-depot-medroxyprogesterone-acetate-than-intravaginal-rings-that-release-etonogestrel-and-ethinyl-estradiol
#39
Mohan Liu, Rodolfo D Vicetti Miguel, Nirk E Quispe Calla, Kristen M Aceves, Linda Fritts, Christopher J Miller, John A Moss, Marc M Baum, Thomas L Cherpes
The injectable progestin depot-medroxyprogesterone acetate (DMPA) is a popular contraceptive choice in sub-Saharan Africa although mouse models indicate it weakens genital epithelial integrity and barrier function and increases susceptibility to genital infection. The intravaginal ring NuvaRing® is another contraceptive option that like DMPA suppresses hypothalamic pituitary ovarian (HPO) axis function with local release of progestin (etonogestrel) and estrogen (ethinyl estradiol). As we previously reported that treating mice with DMPA and estrogen averts the loss of genital epithelial integrity and barrier function induced by DMPA alone, in the current investigation we compared genital levels of the cell-cell adhesion molecule desmoglein-1 (DSG1) and genital epithelial permeability in rhesus macaques (RM) treated with DMPA or a NuvaRing®re-sized for RM (N-IVR)...
January 25, 2023: bioRxiv
https://read.qxmd.com/read/36701333/effect-of-menstrual-irregularity-on-academic-performance-of-undergraduate-students-of-debre-berhan-university-a-comparative-cross-sectional-study
#40
JOURNAL ARTICLE
Enguday Demeke, Abayneh Birlie Zeru, Esubalew Tesfahun, Woineshet Bedru Mohammed
BACKGROUND: Menstrual period is a critical time in the life of females. For the first few years after menarche, irregular cycle is common due to premature hypothalamic-pituitary ovarian (HPO) axis physiologically. If persistent, it becomes a major problem in student's life. But few studies conducted on effect of menstrual cycle irregularity on academic performance among university students were descriptive. However assessing the effect of menstrual irregularity on academic performance by using average grade point approach is critically important to magnify its effect...
2023: PloS One
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