Monica A Wall, Mayara Garcia de Mattos Barbosa, Natalie Hanby, Michelle M Cai, Margaret Brunette, Despina I Pavlidis, Paula Arrowsmith, Ansen Q Tan, Marilia Cascalho, Ariella Shikanov
Premature loss of ovarian function (POI) is associated with numerous negative side effects, including vasomotor symptoms, sleep and mood disturbances, disrupted urinary function, and increased risks for osteoporosis and heart disease. Hormone replacement therapy (HRT), the standard of care for POI, delivers only a subset of ovarian hormones and fails to mimic the monthly cyclicity and daily pulsatility characteristic of healthy ovarian tissue in reproductive-aged individuals whose ovarian tissue contains thousands of ovarian follicles...
March 19, 2024: International Journal of Molecular Sciences