Pekka Määttänen, Eberhard Lurz, Steven R Botts, Richard Y Wu, Chiu William Yeung, Bo Li, Sumayyah Abiff, Kathene C Johnson-Henry, Dion Lepp, Krista A Power, Agostino Pierro, Marc E Surette, Philip M Sherman
Flaxseed is high in omega-3 polyunsaturated fatty acids, fiber and lignans known to lower cholesterol levels. However, its use for prevention or treatment of inflammatory bowel diseases has yielded mixed results, perhaps related to dietary interactions. In this study, we evaluated the impact of ground flaxseed supplementation on the severity of Citrobacter rodentium-induced colitis in the setting of either a high fat (HF; ~36 %kcal) or reduced fat (RF; ~12 %kcal) diet. After weaning, C57BL/6 mice (n=8-15/treatment) were fed ground flaxseed (7g/100g diet) with either HF (HF Flx) or RF (RF Flx) diets for four weeks prior to infection with C...
August 10, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology