keyword
https://read.qxmd.com/read/38486390/armodafinil-as-a-potential-pharmacological-treatment-for-attention-deficit-hyperactivity-disorder-in-adults-a-review
#21
JOURNAL ARTICLE
Reyna Lamas-Aguilar, Araceli Diaz-Ruiz, Luz Navarro, Raúl Miranda-Ojeda, María de Los Ángeles Martínez-Cárdenas, Alfonso Mata-Bermudez, Camilo Rios
INTRODUCTION: Armodafinil is a psychostimulant that promotes alertness, and it has been shown to improve attention, memory, and fatigue in healthy adults and adults with neurodevelopmental conditions that share symptoms with Attention Deficit Hyperactivity Disorder (ADHD). It is generally well tolerated and safe, and most of the adverse events reported are considered not serious. However, the available evidence on the efficacy of armodafinil for the treatment of ADHD in adults is scarce...
March 14, 2024: Current Neuropharmacology
https://read.qxmd.com/read/38486233/early-childhood-exposure-to-environmental-phenols-and-parabens-phthalates-organophosphate-pesticides-and-trace-elements-in-association-with-attention-deficit-hyperactivity-disorder-adhd-symptoms-in-the-charge-study
#22
JOURNAL ARTICLE
Jiwon Oh, Kyoungmi Kim, Kurunthachalam Kannan, Patrick J Parsons, Agnieszka Mlodnicka, Rebecca J Schmidt, Julie B Schweitzer, Irva Hertz-Picciotto, Deborah H Bennett
BACKGROUND: A growing body of literature investigated childhood exposure to environmental chemicals in association with attention-deficit/hyperactivity disorder (ADHD) symptoms, but limited studies considered urinary mixtures of multiple chemical classes. This study examined associations of concurrent exposure to non-persistent chemicals with ADHD symptoms in children diagnosed with autism spectrum disorder (ASD), developmental delay (DD), and typical development (TD). METHODS: A total of 549 children aged 2-5 years from the Childhood Autism Risks from Genetics and Environment (CHARGE) case-control study were administered the Aberrant Behavior Checklist (ABC)...
March 14, 2024: Environmental Health
https://read.qxmd.com/read/38484422/exploring-the-presence-and-impact-of-sensory-differences-in-children-with-developmental-coordination-disorder
#23
JOURNAL ARTICLE
Jennifer Keating, Catherine Purcell, Sarah A Gerson, Ross E Vanderwert, Catherine R G Jones
BACKGROUND: Children with Developmental Coordination Disorder (DCD) can experience sensory differences. There has been limited exploration of these differences and their impact on children with DCD. AIMS: i) To explore the presence and impact of sensory differences in children with DCD compared to children without DCD; ii) To examine whether sensory differences are related to motor ability, attention deficit hyperactivity disorder (ADHD), or autistic traits. METHOD: Parents of children (8-12 years) with (n = 23) and without (n = 33) DCD used standardised questionnaires to report on their children's sensory differences, autistic traits, and ADHD traits...
March 13, 2024: Research in Developmental Disabilities
https://read.qxmd.com/read/38484285/assessing-the-reliability-of-biomechanical-variables-during-a-horizontal-deceleration-task-in-healthy-adults
#24
JOURNAL ARTICLE
Joshua Cross, Stacey M Kung, Neil Welch
Horizontal deceleration technique is an underpinning factor to musculoskeletal injury risk and performance in multidirectional sport. This study primarily assessed within- and between-session reliability of biomechanical and performance-based aspects of a horizontal deceleration technique and secondarily investigated the effects of limb dominance on reliability. Fifteen participants completed four horizontal decelerations on each leg during test and retest sessions. A three-dimensional motion analysis system was used to collect kinetic and kinematic data...
March 14, 2024: Journal of Sports Sciences
https://read.qxmd.com/read/38483760/amygdala-volume-is-associated-with-adhd-risk-and-severity-beyond-comorbidities-in-adolescents-clinical-testing-of-brain-chart-reference-standards
#25
JOURNAL ARTICLE
Ádám Nárai, Petra Hermann, Alexandra Rádosi, Pál Vakli, Béla Weiss, János M Réthelyi, Nóra Bunford, Zoltán Vidnyánszky
UNLABELLED: Understanding atypicalities in ADHD brain correlates is a step towards better understanding ADHD etiology. Efforts to map atypicalities at the level of brain structure have been hindered by the absence of normative reference standards. Recent publication of brain charts allows for assessment of individual variation relative to age- and sex-adjusted reference standards and thus estimation not only of case-control differences but also of intraindividual prediction. METHODS: Aim was to examine, whether brain charts can be applied in a sample of adolescents (N = 140, 38% female) to determine whether atypical brain subcortical and total volumes are associated with ADHD at-risk status and severity of parent-rated symptoms, accounting for self-rated anxiety and depression, and parent-rated oppositional defiant disorder (ODD) as well as motion...
March 14, 2024: Research on child and adolescent psychopathology
https://read.qxmd.com/read/38482850/a-comprehensive-update-on-the-admet-considerations-for-%C3%AE-2%C3%AE-calcium-channel-ligand-medications-for-treating-restless-legs-syndrome
#26
REVIEW
Gaia Pellitteri, Salvatore Versace, Giovanni Merlino, Annacarmen Nilo, Gian Luigi Gigli, Mariarosaria Valente
INTRODUCTION: Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a sleep-related sensory-motor disorder associated with poor sleep quality and impaired daily functioning. In patients affected by chronic RLS/WED, a pharmacological therapy is recommended. International guidelines suggest to start the treatment with a α2δ calcium channel ligand in most cases, unless contraindicated. AREAS COVERED: The present review is based on an extensive Internet and PubMed search from 1986 to 2024...
March 15, 2024: Expert Opinion on Drug Metabolism & Toxicology
https://read.qxmd.com/read/38482702/-neuroanatomical-mapping-of-inhibitory-attention-and-working-memory-with-functional-magnetic-resonance-imaging-in-healthy-children
#27
JOURNAL ARTICLE
R Rosales-Fernández, M Paredes, A Zuñiga, F Durán, N Sarce-Paredes, C Vásquez, J Conejero, F Alarcón-Garrido
INTRODUCTION: The objective is to produce an average brain activation mapping template in healthy children using functional magnetic resonance imaging (fMRI), with specific paradigms for activating inhibitory attention and working memory functions. SUBJECTS AND METHODS: A nutritional and neuropsychological evaluation was performed on 87 right-handed children. The inclusion criteria were met by 30 children (15 boys and 15 girls) between 9 and 11 years old, who were studied with fMRI in two inhibitory attention tests (Go/No Go), with food cues, a working memory test (Continuous Performance Test Identical Pairs) and measurement of anatomical volumes...
March 16, 2024: Revista de Neurologia
https://read.qxmd.com/read/38482568/highly-energetic-n-cyano-substituted-cl-20-analogues-challenging-the-stability-limits-of-polynitro-hexaazaisowurtzitanes
#28
JOURNAL ARTICLE
Vladimir V Parakhin, Galina V Pokhvisneva, Nina I Shlykova, Aida I Samigullina, Sergei V Nikitin, Gennady A Smirnov, Pavel B Gordeev, Tatyana S Kon'kova, David B Lempert, Alla N Pivkina
To design high-energy-density materials of a new level, it is necessary to develop methods for the functionalization of energetic scaffolds, which will make it possible to tune their physicochemical and energetic properties. For this reason, we have elaborated an approach for synthesizing a new series of energetic cage compounds with advanced properties by introducing the N -cyano group into the polynitro hexaazaisowurtzitane framework. The structures of the obtained substances were fully characterized with a combination of methods, including multinuclear (1 H, 13 C{1 H}, 14 N, and 15 N{1 H}) NMR and IR spectroscopy, high-resolution mass spectrometry, X-ray diffraction analysis, electron microscopy and quantum chemical calculations...
March 14, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38480910/brain-based-graph-theoretical-predictive-modeling-to-map-the-trajectory-of-anhedonia-impulsivity-and-hypomania-from-the-human-functional-connectome
#29
JOURNAL ARTICLE
Rotem Dan, Alexis E Whitton, Michael T Treadway, Ashleigh V Rutherford, Poornima Kumar, Manon L Ironside, Roselinde H Kaiser, Boyu Ren, Diego A Pizzagalli
Clinical assessments often fail to discriminate between unipolar and bipolar depression and identify individuals who will develop future (hypo)manic episodes. To address this challenge, we developed a brain-based graph-theoretical predictive model (GPM) to prospectively map symptoms of anhedonia, impulsivity, and (hypo)mania. Individuals seeking treatment for mood disorders (n = 80) underwent an fMRI scan, including (i) resting-state and (ii) a reinforcement-learning (RL) task. Symptoms were assessed at baseline as well as at 3- and 6-month follow-ups...
March 13, 2024: Neuropsychopharmacology
https://read.qxmd.com/read/38480031/psychopathology-disordered-eating-and-impulsivity-as-predictors-of-weight-loss-24-months-after-metabolic-and-bariatric-surgery
#30
JOURNAL ARTICLE
David B Sarwer, Thomas A Wadden, Rebecca Ashare, Jacqueline C Spitzer, Courtney McCuen-Wurst, Caitlin LaGrotte, Noel Williams, Rohit Soans, Colleen Tewksbury, Jingwei Wu, Gabriel Tajeu, Kelly C Allison
BACKGROUND: The relationship between theoretically relevant psychosocial and behavioral variables and outcomes of metabolic and bariatric surgery remains unclear. Some studies have found that the presence of psychopathology, disordered eating, and impulsivity, either before surgery or during the early postoperative period, is associated with suboptimal postoperative weight loss. Other studies have not found these relationships. OBJECTIVE: Examine the relationship between psychopathology, disordered eating, impulsivity, and weight loss 24 months postoperatively...
February 7, 2024: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/38478999/examining-profiles-and-treatment-outcomes-in-dual-diagnosis-comparison-of-coordinated-treatment-with-mental-health-services-versus-addiction-center-alone-a-real-world-data-analysis
#31
JOURNAL ARTICLE
Cinta Mancheño-Velasco, Marta Narváez-Camargo, Daniel Dacosta-Sánchez, Manuel Sánchez-García, Óscar M Lozano
Objective : The aim of this work was to examine the profile and treatment outcomes of patients with dual pathology depending on whether the patients were attending addiction centers or are being treated in a coordinated model by mental health services. Methods : Data from 7225 dual diagnosis patients were used, of whom 2417 (33.5%) received treatment in the mental health coordinated modality. Clinical information was taken from the patients' electronic health record. Results : Differences were found in patients' sociodemographic and comorbidity profiles according to treatment modality...
March 13, 2024: Journal of Dual Diagnosis
https://read.qxmd.com/read/38478449/leader-following-synchronization-control-of-multiagent-systems-under-hybrid-cyber-attacks-via-impulsive-control-based-on-topology-switching
#32
JOURNAL ARTICLE
Hongyun Dai, Lianghao Ji, Xing Guo, Cuijuan Zhang, Shasha Yang, Huaqing Li
This article investigates the leader-following synchronization problem of multiagent systems (MASs) under hybrid cyber attacks, which refers to deception attacks and multichannel independent denial-of-service (DoS) attacks in communication channels. In order to achieve the secure control of MASs under hybrid cyber attacks, a novel impulsive control method based on topology switching is proposed, and a new algorithm for determining impulsive instants is designed. In addition, the cooperative-competitive relationship between agents is also considered, which is more in line with reality...
March 13, 2024: IEEE Transactions on Cybernetics
https://read.qxmd.com/read/38478358/early-predictors-and-concurrent-correlates-of-tonic-and-phasic-irritability-in-adolescence
#33
JOURNAL ARTICLE
Leah K Sorcher, Jamilah Silver, Emma Chad-Friedman, Gabrielle A Carlson, Daniel N Klein, Lea R Dougherty
Irritability is a common presenting problem in youth mental health settings that is thought to include two components: tonic (e.g., irritable, touchy mood) and phasic (e.g., temper outbursts), each with unique correlates and outcomes, including later internalizing and externalizing problems, respectively. However, we are unaware of any studies of early predictors of tonic and phasic irritability. We utilized data from a longitudinal study of a community sample of 3-year-old children followed to age 15 (n = 444)...
March 13, 2024: Research on child and adolescent psychopathology
https://read.qxmd.com/read/38478212/correction-impulse-control-disorders-in-patients-with-dopamine-agonist-treated-pituitary-adenomas-a-cross-sectional-multicenter-study
#34
Mussa H Almalki, Moayad A Alsuraikh, Eyad Almalki, Faisal Aziz, Raya Almazrouei, Khaled M AlDahmani, Fahad Alshahrani, Meshal Alaqeel, Moeber Mahzari, Aishah Ekhzaimy
No abstract text is available yet for this article.
March 13, 2024: Pituitary
https://read.qxmd.com/read/38478035/fda-approved-fezolinetant-veozah-a-critical-evaluation-of-its-efficacy-and-safety-for-menopausal-vasomotor-symptoms-calling-for-prospective-research
#35
JOURNAL ARTICLE
Priya Rani, Dua Zehra, Malaika Mansoor, Payal Rani
Women going through menopause frequently experience vasomotor symptoms such as hot flashes, night sweats, and sleep disturbances, significantly influencing their quality of life. Hormonal therapy has been demonstrated to be beneficial in treating VMS. However, due to specific restrictions, it is not recommended for every woman. Fezolinetant, a neurokinin 3 antagonist and non-hormonal treatment for severe to moderate VMS, functions by inhibiting neuronal impulses originating from the hypothalamic thermoregulatory center...
March 13, 2024: Archives of Women's Mental Health
https://read.qxmd.com/read/38477831/a-rare-case-of-essential-thrombocythemia-with-pseudo-hyperkalemia
#36
JOURNAL ARTICLE
Ugur Kalan, Jale Vardi, Selin Kucukyurt Kaya, Ahmet Kursad Gunes
Essential thrombocythemia (ET) is a rare clonal stem cell disorder that affects the production of platelets in the bone marrow. This condition causes an overproduction of platelets, which can lead to blood clots and other complications. Potassium, on the other hand, is an essential mineral that plays a vital role in various bodily functions, including nerve impulses and muscle contractions. Here, in this case report, we investigated a case of pseudo-hyperkalemia caused by essential thrombocythemia in a 77-year-old woman with very high platelet counts...
March 14, 2024: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/38477651/a-continuous-ultra-narrow-impulse-synchronizer-using-a-monolithic-field-programmable-gate-array-for-fast-deployment-and-scalability
#37
JOURNAL ARTICLE
Yuli Ye, Xiongjie Zhang, Shuai Ma, Peng Li, Dexin Xiao, Kui Zhou, Xinfan Yang, Ming Li, Dai Wu, Feng Li, Ge Jin, Ziru Sang
Ultra-narrow pulses serve as critical components in numerous applications. These pulses have ultra-fast leading edges that typically function as precision trigger signals to synchronize various instruments. Ultra-narrow pulses inherently exhibit an ultra-wide bandwidth, gaining significant attention in diverse electronic systems encompassing communications, radar imaging, electronic warfare, and others. Although several techniques have been explored for generating ultra-narrow pulses, field programmable gate arrays (FPGAs) offer a promising alternative in terms of flexibility and integration...
March 1, 2024: Review of Scientific Instruments
https://read.qxmd.com/read/38477311/badminton-as-a-dynamic-system-a-new-method-for-analyzing-badminton-matches-based-on-perturbations
#38
JOURNAL ARTICLE
Fabian Hammes, Daniel Link
This study presents a method for analysing badminton matches based on the concept of perturbations. We transfer this principle to a badminton rally and describe the decisive shot, which turns a balanced situation into an advantage for one team or one player. Our paper proposes an observational system, which models the decisive shots by using four consecutive actions: impulse (the perturbation), follow-up , survival , and convert . To test the objectivity of the operationalization, independent raters analysed six matches in the singles disciplines of the 2022 World Championships...
March 13, 2024: Journal of Sports Sciences
https://read.qxmd.com/read/38476615/individual-risk-factors-and-prediction-of-gambling-disorder-in-online-sports-bettors-the-longitudinal-rigab-study
#39
JOURNAL ARTICLE
Theresa Wirkus, Robert Czernecka, Gerhard Bühringer, Anja Kräplin
INTRODUCTION: While research in online sports betting is dominated by studies using objective player tracking data from providers to identify risky gambling behavior, basicresearch has identified various putative individual risk factors assumed to underlie the development of gambling disorder across all types of gambling. This study aims to examine individual risk factors and their longitudinal clinical relevance in online sports bettors. METHODS: German online sports bettors ( N = 607, Mage = 34, 92% male) from a provider based sample took part in an online survey...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38476612/observation-of-human-animal-interaction-for-research-ohaire-behavior-coding-in-a-randomized-control-trial-of-children-with-attention-deficit-hyperactivity-disorder-adhd-and-a-canine-assisted-intervention
#40
JOURNAL ARTICLE
Leanne O Nieforth, Noémie A Guerin, Annamarie Stehli, Sabrina E B Schuck, Katherine Yi, Marguerite E O'Haire
INTRODUCTION: Diagnosed in about 10% of children in the United States, attention-deficit hyperactivity disorder (ADHD) is characterized by symptoms including inattention, hyperactivity, and impulsivity. Traditional interventions, such as pharmacological and psychological interventions, are often used in conjunction with integrative health options, such as animal-assisted interventions. The objective of this manuscript is to report behavior coding findings from a randomized control trial of children with ADHD...
2024: Frontiers in Psychiatry
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