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https://www.readbyqxmd.com/read/29777691/improving-electrical-properties-of-ipsc-cardiomyocytes-by-enhancing-cx43-expression
#1
Valentin Sottas, Carl-Mattheis Wahl, Mihnea C Trache, Michael Bartolf-Kopp, Sidney Cambridge, Markus Hecker, Nina D Ullrich
The therapeutic potential of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is limited by immature functional features including low impulse propagation and reduced cell excitability. Key players regulating electrical activity are voltage-gated Na+ channels (Nav 1.5) and gap junctions built from connexin-43 (Cx43). Here we tested the hypothesis that enhanced Cx43 expression increases intercellular coupling and influences excitability by modulating Nav 1.5. Using transgenic approaches, Cx43 and Nav 1...
May 16, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29777193/on-spiking-behaviour-of-oyster-fungi-pleurotus-djamor
#2
Andrew Adamatzky
We recorded extra-cellular electrical potential of fruit bodies of oyster fungi Pleurotus djamor. We demonstrated that the fungi generate action potential like impulses of electrical potential. Trains of the spikes are observed. Two types of spiking activity are uncovered: high-frequency (period 2.6 min) and low-frequency (period 14 min); transitions between modes of spiking are illustrated. An electrical response of fruit bodies to short (5 sec) and long (60 sec) thermal stimulation with open flame is analysed in details...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29775836/cognitive-and-behavioural-dispositions-in-offspring-at-high-risk-for-alcoholism
#3
Rajesh Kumar, Keshav Janakiprasad Kumar, Vivek Benegal
OBJECTIVES: Offspring with family history of alcoholism are considered to be at high risk for alcoholism. The present study sought to expand our understanding of cognitive and behavioural dispositions associated with executive control and self-regulation in alcohol naïve offspring with and without family history of alcoholism. METHODS: Sample comprised of alcohol naive offspring in two groups: (i) at high risk (n = 34) and (ii) at low risk for alcoholism (n = 34)...
May 15, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29774393/developmental-origin-of-the-cardiac-conduction-system-insight-from-lineage-tracing
#4
Rajiv A Mohan, Bastiaan J Boukens, Vincent M Christoffels
The components of the cardiac conduction system (CCS) generate and propagate the electrical impulse that initiates cardiac contraction. These interconnected components share properties, such as automaticity, that set them apart from the working myocardium of the atria and ventricles. A variety of tools and approaches have been used to define the CCS lineages. These include genetic labeling of cells expressing lineage markers and fate mapping of dye labeled cells, which we will discuss in this review. We conclude that there is not a single CCS lineage, but instead early cell fate decisions segregate the lineages of the CCS components while they remain interconnected...
May 17, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29774073/polypyrrole-chitosan-conductive-biomaterial-synchronizes-cardiomyocyte-contraction-and-improves-myocardial-electrical-impulse-propagation
#5
Zhi Cui, Nathan C Ni, Jun Wu, Guo-Qing Du, Sheng He, Terrence M Yau, Richard D Weisel, Hsing-Wen Sung, Ren-Ke Li
Background: The post-myocardial infarction (MI) scar interrupts electrical impulse propagation and delays regional contraction, which contributes to ventricular dysfunction. We investigated the potential of an injectable conductive biomaterial to restore scar tissue conductivity and re-establish synchronous ventricular contraction. Methods: A conductive biomaterial was generated by conjugating conductive polypyrrole (PPY) onto chitosan (CHI) backbones. Trypan blue staining of neonatal rat cardiomyocytes (CMs) cultured on biomaterials was used to evaluate the biocompatibility of the conductive biomaterials...
2018: Theranostics
https://www.readbyqxmd.com/read/29773798/probing-femtosecond-lattice-displacement-upon-photo-carrier-generation-in-lead-halide-perovskite
#6
Giovanni Batignani, Giuseppe Fumero, Ajay Ram Srimath Kandada, Giulio Cerullo, Marina Gandini, Carino Ferrante, Annamaria Petrozza, Tullio Scopigno
Electronic properties and lattice vibrations are expected to be strongly correlated in metal-halide perovskites, due to the soft fluctuating nature of their crystal lattice. Thus, unveiling electron-phonon coupling dynamics upon ultrafast photoexcitation is necessary for understanding the optoelectronic behavior of the semiconductor. Here, we use impulsive vibrational spectroscopy to reveal vibrational modes of methylammonium lead-bromide perovskite under electronically resonant and non-resonant conditions...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29773097/polymorphism-in-rs2229783-of-the-alpha-1-xi-collagen-gene-is-associated-with-susceptibility-to-but-not-severity-of-kashin-beck-disease-in-a-northwest-chinese-han-population
#7
Xiao Wei Shi, Feng Zhang, Zhi Yan Li, Ai Li Lyu, Xiong Guo
A case-control study was conducted to investigate associations between organophosphate pesticide (OP) exposure, aggression, impulsivity, and attempted suicide. The purpose of this study was to explore whether genomic polymorphisms in the alpha 1(XI) collagen gene (COL11A1) were associated with the risk and severity of Kashin-Beck disease (KBD). Twenty-two single nucleotide polymorphisms (SNPs) in COL11A1 were genotyped in 274 KBD cases and 249 healthy controls using the Sequenom MassARRAY system. The expression of type XI collagen (COL11A) in the knee articular cartilage of 22 KBD patients and 21 controls was analyzed by immunohistochemistry...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772740/tactile-estimation-of-molded-plastic-plates-based-on-the-estimated-impulse-responses-of-mechanoreceptive-units
#8
Lisako Nobuyama, Yuta Kurashina, Kei Kawauchi, Koji Matsui, Kenjiro Takemura
This study proposes a tactile estimation method of molded plastic plates based on human tactile perception characteristics. Plastic plates are often used in consumer products. The tactile evaluation plays an important role in product development. However, physical quantities not taking into account human tactile perception have been employed in previous tactile estimation procedures. Hence, in this study, we adopted the vibrational thresholds of the mechanoreceptive units-FA I, FA II, SA I and SA II-for stimuli detection and developed a tactile estimation method for plastic plates that clarified the mechanoreceptive units related to tactile sensation...
May 16, 2018: Sensors
https://www.readbyqxmd.com/read/29772488/minnesota-impulse-disorders-interview-midi-validation-of-a-structured-diagnostic-clinical-interview-for-impulse-control-disorders-in-an-enriched-community-sample
#9
Samuel R Chamberlain, Jon E Grant
BACKGROUND: Disorders of impulsivity are common, functionally impairing, and highly relevant across different clinical and research settings. Few structured clinical interviews for the identification and diagnosis of impulse control disorders exist, and none have been validated in a community sample in terms of psychometric properties. METHODS: The Minnesota Impulse control disorders Interview (MIDI v2.0) was administered to an enriched sample of 293 non-treatment seeking adults aged 18-35 years, recruited using media advertisements in two large US cities...
May 8, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29771563/induced-sadness-increases-persistence-in-a-simulated-slot-machine-task-among-recreational-gamblers
#10
Gaëtan Devos, Luke Clark, Pierre Maurage, Joël Billieux
Gambling may constitute a strategy for coping with depressive mood, but a direct influence of depressive mood on gambling behaviors has never been tested via realistic experimental designs in gamblers. The current study tested whether experimentally induced sadness increases persistence on a simulated slot machine task using real monetary reinforcement in recreational gamblers. Sixty participants were randomly assigned to an experimental (sadness induction) or control (no emotional induction) condition, and then performed a slot machine task consisting of a mandatory phase followed by a persistence phase...
May 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29771559/body-mass-index-across-adolescence-and-substance-use-problems-in-early-adulthood
#11
Ashley N Gearhardt, Rebecca Waller, Jennifer M Jester, Luke W Hyde, Robert A Zucker
Excessive substance use and obesity are underpinned by a number of shared risk factors (e.g., reward dysfunction, impulsivity). Food and drugs of abuse engage similar reward-related neural circuitry and the food-drug competition hypothesis proposes that excess consumption of food may diminish desire for drugs of abuse by competing for neural receptors associated with reward and motivation. Adolescence is a high-risk period for both increased substance use and excessive weight gain. In the present study, the authors tested whether, consistent with the food-drug competition hypothesis, elevated body mass index (BMI) across adolescence predicted fewer substance use problems in young adulthood...
May 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29771540/mechanistic-study-of-the-reactions-of-methyl-peroxy-radical-with-methanol-or-hydroxyl-methyl-radical
#12
Zhongrui Zhao, Jinou Song, Boyang Su, Xiaowen Wang, Zhijun Li
An ab initio and direct dynamic study on the reactions of CH3O2 + CH3OH and CH3O2 + CH2OH has been carried out over the temperature range of 300 - 1500 K. All stationary points were calculated at MP2/Aug-cc-pVTZ level of theory for CH3O2 + CH3OH or at M06-2X/MG3S level of theory for CH3O2 + CH2OH and identified for local minimum. The energetic parameters were refined at QCISD (T)/cc-pVTZ and CCSD (T)/aug-cc-pVTZ levels of theory. For the reaction of CH3OO + CH3OH, two hydrogen abstraction channels producing CH3OOH+CH2OH (R1) and CH3OOH+CH3O (R2) were confirmed...
May 17, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29771311/pathobiology-of-cardiac-dyssynchrony-and-resynchronization-therapy
#13
Uyên Châu Nguyên, Nienke J Verzaal, Frans A van Nieuwenhoven, Kevin Vernooy, Frits W Prinzen
Synchronous ventricular electrical activation is a prerequisite for adequate left ventricular (LV) systolic function. Conduction abnormalities such as left bundle branch block, and ventricular pacing lead to a dyssynchronous electrical activation sequence, which may have deleterious consequences. The present review attempts to connect the various processes involved in the development of 'dyssynchronopathy', and its correction by cardiac resynchronization therapy (CRT). Abnormal electrical impulse conduction leads to abnormal contraction, characterized by regional differences in timing as well as shortening patterns and amount of external work performed...
May 15, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29771183/association-of-inattention-hyperactivity-and-hypersomnolence-in-two-clinic-based-adult-cohorts
#14
Régis Lopez, Jean-Arthur Micoulaud-Franchi, Laura Camodeca, Marie Gachet, Isabelle Jaussent, Yves Dauvilliers
OBJECTIVE: To assess the relationship between excessive daytime sleepiness (EDS), inattention, and hyperactivity/impulsivity in adults with ADHD and central hypersomnia. METHOD: Drug-free adult patients with ADHD ( n = 100) or hypersomnia ( n = 100) were evaluated using a structured clinical interview and self-report questionnaires on ADHD symptoms and EDS. RESULTS: In all, 61% of patients with hypersomnia had clinically significant ADHD symptoms with 25% having an ADHD diagnosis (with both childhood and adulthood ADHD symptoms) and 36% ADHD-like symptoms, without history of childhood ADHD...
May 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29771172/measuring-impulsivity-in-children-adaptation-and-validation-of-a-short-version-of-the-upps-p-impulsive-behaviors-scale-in-children-and-investigation-of-its-links-with-adhd
#15
Marie Geurten, Corinne Catale, Philippe Gay, Sandrine Deplus, Joël Billieux
OBJECTIVE: Impulsivity is a multifaceted construct known to play a crucial role in the development and maintenance of a wide range of problematic behaviors and psychological disorders in children. METHOD: In this study, we adapted the short French adult version of the UPPS-P (urgency-premeditation-perseverance-sensation seeking-positive urgency) Impulsive Behaviors Scale for use with children (short UPPS-P-C) and tested its psychometric properties. RESULTS: Confirmatory factor analyses conducted on a sample of 425 children (aged 8-14 years) supported the five-factor structure of the scale...
May 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29771078/-analysis-of-the-difference-between-the-results-of-caloric-tests-and-video-head-pulse-tests-in-patients-with-vestibular-migraine-and-vestibular-neuritis
#16
W Wang, Y C Yang, J H Zhuang, F Li, B Gao
Objective: To compare the results of caloric tests and video head impulse tests (VHIT) in patients with vestibular migraine (VM) and vestibular neuritis (VN), so as to provide help for the differential diagnosis of the two patients. Method: Retrospectively analyze VM and VN patients within 2 weeks of onset from August 1, 2016 to December 31, 2017 in neurology clinic of the Changzheng Hospital of Second Military Medical University, all patients were examined by caloric tests and VHIT, and the results of the two groups were compared and analyzed...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770569/frontal-cortical-thickness-correlates-positively-with-impulsivity-in-early-psychosis-male-patients
#17
Philipp S Baumann, Paul Klauser, Alessandra Griffa, Philippe Golay, Julie Palix, Luis Alameda, Valérie Moulin, Patric Hagmann, Kim Q Do, Philippe Conus
AIM: Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behaviours and participate to the burden of psychotic illness. Given that morphological brain correlates of impulsivity in schizophrenia have been poorly investigated especially in young adults, the aim of this study was to investigate the relationship between impulsivity and cortical thickness in early psychosis (EP) patients. METHOD: A total of 17 male subjects in the early phase of psychosis were recruited...
May 17, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29770366/complete-resolution-of-left-atrial-appendage-thrombosis-with-oral-dabigatran-etexilate-in-a-patient-with-myotonic-dystrophy-type-1-and-atrial-fibrillation
#18
Anna Rago, Andrea Antonio Papa, Giulia Arena, Marco Mosella, Antonio Cassese, Alberto Palladino, Paolo Golino
Myotonic Dystrophy type 1 (DM1) is the most common muscular dystrophy in adult life characterized by muscle dysfunction and cardiac conduction abnormalities. Atrial fibrillation frequently occurs in DM1 patients. It's related to the discontinuous and inhomogeneous propagation of sinus impulses and to the prolongation of atrial conduction time, caused by progressive fibrosis and fatty replacement of the myocardium. AF predisposes to a hyper-coagulable state and to an increased risk of thromboembolism. We report the first case of complete resolution of left atrial appendage thrombosis with oral dabigatran etexilate in a myotonic dystrophy type I patient with atrial fibrillation scheduled for transesophageal echocardiogram-guided direct current cardioversion...
December 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29770228/acoustic-radiation-force-impulse-arfi-elastography-in-a-cohort-of-alpha-1-antitrypsin-deficient-individuals-and-healthy-volunteers
#19
Sandra Diaz, Behrouz Mostafavi, Hanan A Tanash, Eeva Piitulainen
Background: Acoustic radiation force impulse (ARFI) elastography has been used to assess liver stiffness non-invasively. However, its usefulness in alpha-1 antitripsin-deficient (AATD) individuals is unknown. Purpose: To assess if liver fibrosis is present in a cohort of AATD individuals using ARFI elastography. Material and Methods: Eighty-three participants aged 38-39 years, except for two who were aged 40 years, underwent ultrasound elastography of the liver with ARFI technique...
April 2018: Acta Radiologica Open
https://www.readbyqxmd.com/read/29770144/global-exponential-stability-of-markovian-jumping-stochastic-impulsive-uncertain-bam-neural-networks-with-leakage-mixed-time-delays-and-%C3%AE-inverse-h%C3%A3-lder-activation-functions
#20
C Maharajan, R Raja, Jinde Cao, G Ravi, G Rajchakit
This paper concerns the problem of enhanced results on robust finite time passivity for uncertain discrete time Markovian jumping BAM delayed neural networks with leakage delay. By implementing a proper Lyapunov-Krasovskii functional candidate, reciprocally convex combination method, and linear matrix inequality technique, we derive several sufficient conditions for varying the passivity of discrete time BAM neural networks. Further, some sufficient conditions for finite time boundedness and passivity for uncertainties are proposed by employing zero inequalities...
2018: Advances in Difference Equations
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