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galectin 9

Blazej Michalski, Przemyslaw Trzcinski, Karolina Kupczynska, Dawid Miskowiec, Lukasz Peczek, Barbara Nawrot, Piotr Lipiec, Jaroslaw D Kasprzak
BACKGROUND: The aim of the study was to assess the correlation of the selected biomarkers and collagen turn-over indices with advanced echocardiographic parameters among patients with preserved and reduced ejection fraction (EF). METHODS: We included 62 patients with the symptomatic heart failure. The patients were divided in to two groups according to the evaluated ejection fraction (EF - Simpson method): heart failure with reduced ejection fraction (HFrEF) group - 30 patients with low EF - 35-50% (16 male, mean age 54...
October 17, 2016: Cardiology Journal
Eun Young Hwang, Mi Suk Jeong, Sang Kyun Park, Sung Chul Ha, Hak Sun Yu, Se Bok Jang
Toxascaris leonina Galectin (Tl-gal) is a galectin-9 homologue protein isolated from an adult worm of the canine gastrointestinal nematode parasite, and Tl-gal vaccinated challenge can inhibit inflammation in Inflammatory Bowel Disease (IBD)-induced mice. We determined the first X-ray structures of full-length Tl-gal complexes with carbohydrates (lactose, LacNAc, Lacto-N-tetraose (LNT), SiaLac, and glucose). Bonds were formed on concave surfaces of both CRDs in Tl-gal. All binding sites are discovered in the HXXXR and WGXEER motifs...
October 14, 2016: Journal of Biological Chemistry
M Batlle, B Campos, M Farrero, M Cardona, B González, M A Castel, J Ortiz, E Roig, M J Pulgarín, J Ramírez, J L Bedini, M Sabaté, P García de Frutos, F Pérez-Villa
BACKGROUND: Prognostic biomarkers are needed to improve the management of the heart failure (HF) epidemic, being the brain natriuretic peptides the most valuable. Here we evaluate 3 biomarkers, high sensitivity troponin T (hs-TnT), galectin-3 (Gal-3) and C-terminal propeptide of type I procollagen (CICP), compare them with a recently described new candidate (sAXL), and analyze their relationship with BNP. METHODS: HF patients with reduced ejection fraction (n=192) were included in this prospective observational study, with measurements of candidate biomarkers, functional, clinical and echocardiographic variables...
September 28, 2016: International Journal of Cardiology
Z Yilmaz, O Eralp Inan, M Kocaturk, A T Baykal, O Hacariz, I Hatipoglu, A Tvarijonaviciute, M Cansev, J Ceron, I H Ulus
BACKGROUND: This study aimed to investigate the possible serum protein changes after endotoxin administration in healthy and choline-treated calves using proteomics. These results are expected to contribute to the understanding of the pathophysiological mechanisms of endotoxemia and the beneficial effect of choline administration in this clinical situation. METHODS: Healthy-calves (n = 20) were divided into 4 groups: Control, Choline treated (C), Lipopolysaccharide administered (LPS), and LPS + C...
2016: BMC Veterinary Research
Akira Nishio, Tomohide Tatsumi, Takatoshi Nawa, Takahiro Suda, Teppei Yoshioka, Yoshiki Onishi, Satoshi Aono, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Daisuke Okuzaki, Takasuke Fukuhara, Yoshiharu Matsuura, Naoki Hiramatsu, Tetsuo Takehara
: NK cell activation is associated with both liver injury and persistent infection in chronic hepatitis C (CHC); however, the detail mechanism of this activation has not yet been fully elucidated. As Galectin-9 (Gal-9) is reported to be increased in the serum and liver tissue of CHC patients, we investigated the function of Gal-9 in NK cell activation in CHC. First, we evaluated the function of Gal-9 on NK cytotoxicity in vitro. Gal-9 treatment resulted in increased cytotoxicity of naïve NK cells, and the Gal-9-activated NK cells demonstrated cytotoxicity toward hepatoma cells and T cells...
September 19, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Grażyna Sygitowicz, Mariusz Tomaniak, Krzysztof J Filipiak, Łukasz Kołtowski, Dariusz Sitkiewicz
BACKGROUND: Galectin-3 (Gal-3) as a biomarker of fibrosis and inflammation has been implicated in the development and progression of heart failure (HF) and may predict increased morbidity and mortality in society. OBJECTIVES: In this preliminary report we investigated the utility of a novel serum marker for the diagnosis of acute HF (AHF). MATERIAL AND METHODS: The study involved 14 AHF patients aged 67.0 ± 14.6 yrs. with left ventricular ejection fraction (LVEF) 29...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Isabel Gonçalves Silva, Laura Rüegg, Bernhard F Gibbs, Marco Bardelli, Alexander Fruehwirth, Luca Varani, Steffen M Berger, Elizaveta Fasler-Kan, Vadim V Sumbayev
The immune receptor Tim-3 is often highly expressed in human acute myeloid leukemia (AML) cells where it acts as a growth factor and inflammatory receptor. Recently, it has been demonstrated that Tim-3 forms an autocrine loop with its natural ligand galectin-9 in human AML cells. However, the pathophysiological functions of Tim-3 in human AML cells remain unclear. Here, we report for the first time that Tim-3 is required for galectin-9 secretion in human AML cells. However, this effect is cell-type specific and was found so far to be applicable only to myeloid (and not, for example, lymphoid) leukemia cells...
July 2016: Oncoimmunology
Ayumi Iwata, Yoshihiro Kamada, Yusuke Ebisutani, Akiko Yamamoto, Yui Ueda, Hitomi Arai, Hironobu Fujii, Shinji Takamatsu, Nobuhiro Maruyama, Masahiro Maeda, Tetsuo Takehara, Eiji Miyoshi
AIM: We identified Mac-2 (galectin-3) binding protein (Mac-2bp) as a novel diagnostic and liver fibrosis predicting biomarker for nonalcoholic steatohepatitis in humans. In mouse models, there are no serum biomarkers predicting liver disease severity. In this study, we developed a mouse Mac-2bp enzyme-linked immunosorbent assay (ELISA) system and determined its efficacy for predicting the severity of liver disease in mouse models, especially in non-alcoholic fatty liver disease (NAFLD) models...
September 11, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Sebastian John, Rashmi Mishra
Galectins is a family of non-classically secreted, beta-galactoside-binding proteins that has recently received considerable attention in the spatio-temporal regulation of surface 'signal lattice' organization, membrane dynamics, cell-adhesion and disease therapeutics. Galectin-9 is a unique member of this family, with two non-homologous carbohydrate recognition domains joined by a linker peptide sequence of variable lengths, generating isoforms with distinct properties and functions in both physiological and pathological settings, such as during development, immune reaction, neoplastic transformations and metastasis...
September 2016: Journal of Biosciences
Tomohiro Arikawa, Shengjun Liao, Hiroki Shimada, Tomoki Inoue, Hiromi Sakata-Haga, Takanori Nakamura, Toshihisa Hatta, Hiroki Shoji
Placental development and trophoblast invasion of the maternal endometrium establish the maternal-fetal interface, which is critical for the developing embryo and fetus. Herein we show that overexpression of Galectin-4 (Gal-4) during trophoblast differentiation inhibited the enlargement of Rcho-1 cells (a model for rat trophoblast differentiation) and promoted cell-cell adhesion, whereas trophoblast specific markers and MMP-9 activity were not affected. In the rat placenta, microtubule associated protein 1 light chain 3 alpha (LC3) protein, an autophagy marker, is highly expressed on the maternal side of the decidua where Gal-4 expression is weak...
2016: Scientific Reports
Jinfeng Liu, Shiguang Huang, Xin-Zhuan Su, Jianping Song, Fangli Lu
Malaria-associated acute lung injury (ALI) is a frequent complication of severe malaria that is often caused by "excessive" immune responses. To better understand the mechanism of ALI in malaria infection, here we investigated the roles of galectin (Gal)-1, 3, 8, 9 and the receptors of Gal-9 (Tim-3, CD44, CD137, and PDI) in malaria-induced ALI. We injected alpha (α)-lactose into mice-infected with Plasmodium berghei ANKA (PbANKA) to block galectins and found significantly elevated total proteins in bronchoalveolar lavage fluid, higher parasitemia and tissue parasite burden, and increased numbers of CD68(+) alveolar macrophages as well as apoptotic cells in the lungs after blockage...
2016: Scientific Reports
Márcia Maria Noya-Rabelo, Ticiana Ferreira Larocca, Carolina Thé Macêdo, Jorge Andion Torreão, Bruno Solano de Freitas Souza, Juliana Fraga Vasconcelos, Luciana Estrella Souza, Agnaluce Moreira Silva, Ricardo Ribeiro Dos Santos, Luís Claudio Lemos Correia, Milena Botelho Pereira Soares
OBJECTIVES: Chagas cardiomyopathy has worse long-term outcomes than other cardiomyopathies. A biomarker strategy to refer subjects for noninvasive cardiac imaging may help in the early identification of cardiac damage in subjects with Chagas disease. Galectin-3 (Gal-3) is a mediator of cardiac fibrosis shown to be upregulated in animal models of decompensated heart failure. Here we assessed the correlation of Gal-3 with myocardial fibrosis in patients with Chagas disease. METHODS: This study comprised 61 subjects with Chagas disease...
August 23, 2016: Cardiology
Xuemei Feng, Juan Feng
The present study evaluated associations between the percentages of T cell immunoglobulin and mucin domain 3 (Tim3)-positive T cells and related cytokines and multiple sclerosis (MS). We collected peripheral blood samples from 30 MS patients and 30 healthy controls. Flow cytometry was used to determine the proportions of CD3(+)Tim3(+), CD4(+)Tim3(+), and CD4(+)CD25(+)Tim3(+) in peripheral blood mononuclear cells (PBMCs) and related cell subsets. The serum concentrations of galectin-9, IL-17, and IFN-γ also were determined using enzyme-linked immunosorbent assays (ELISA)...
August 17, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Bindongo P P Dembele, Haorile Chagan-Yasutan, Toshiro Niki, Yugo Ashino, Noppadon Tangpukdee, Egawa Shinichi, Srivicha Krudsood, Shigeyuki Kano, Toshio Hattori
BACKGROUND: Galectin-9 (Gal-9) is a β-galactoside-binding lectin that interacts with sugar moieties on glycoproteins and glycolipids of cells and pathogens. Gal-9 is known as an immune modulator that induces cell death via interaction with T cell immunoglobulin and mucin domain-3 (Tim3), a co-inhibitory receptor, and it inhibits production of several pro-inflammatory cytokines (TNF, IL-6 and IL-1α) and enhances production of IL-10. To understand the immune pathology of malaria, the Gal-9 in plasma was measured...
2016: Malaria Journal
A Rogier van der Velde, Wouter C Meijers, Edwin R van den Heuvel, Stephan J Bakker, Wiek H van Gilst, Pim van der Harst, Hans Hillege, Rudolf A de Boer
BACKGROUND: High baseline galectin-3 levels are associated with increased risk for adverse cardiovascular outcomes in the general population, but determinants of changes in galectin-3 levels over time have not been established. Therefore, we aimed to identify determinants of (temporal) change in galectin-3 levels. METHODS: Galectin-3 plasma levels were measured in a large community based cohort (PREVEND study) at 3 different time points: at baseline, after ~4 and ~9years...
November 1, 2016: International Journal of Cardiology
Yuka Tanino, Takashi Hashimoto, Takao Ojima, Masashi Mizuno
Fucoidan is a sulfated polysaccharide from brown sea algae. In the present study, it was demonstrated that oral administration of F-fucoidan from Saccharina japonica possessed anti-allergic effects using the passive cutaneous anaphylaxis reaction, but not by intraperitoneal administration. The inhibitory mechanism was dependent on galectin-9, which belongs to a soluble lectin family that recognizes β-galactoside and prevents IgE binding to mast cells. The anti-allergy properties of F-fucoidan were cancelled by an intravenous dose of anti-galectin-9 antibody or lactose, which bind competitively with galectin-9 before the passive cutaneous anaphylaxis reaction...
July 2016: Journal of Clinical Biochemistry and Nutrition
Fabian Sanchis-Gomar, Marta López-Ramón, Rafael Alis, Nuria Garatachea, Helios Pareja-Galeano, Alejandro Santos-Lozano, Pilar Catalán, Veronica Sansoni, Silvia Perego, Giovanni Lombardi, Herbert Löllgen, Hector Bueno, Enrique Serrano-Ostáriz, Alejandro Lucia
BACKGROUND: The impact of high exercise loads on a previously healthy heart remains controversial. We examined the consequences of decades of strenuous endurance exercise at the highest competition level on heart dimensions and volumes as well as on serum biomarkers of cardiac fibrosis/remodeling. METHODS AND RESULTS: We compared echocardiographic measurements and serum biomarkers of cardiac fibrosis/remodeling [troponin I, galectin-3, matrix metallopeptidase-2 and -9, N-terminal pro-brain natriuretic peptide, carboxy-terminal propeptide of type I procollagen, and soluble suppressor of tumorigenicity-2 (sST-2)/interleukin(IL)-1R4] in 53 male athletes [11 former professional ('elite') and 42 amateur-level ('sub-elite') cyclists or runners, aged 40-70years] and 18 aged-matched controls...
November 1, 2016: International Journal of Cardiology
Elizabeth Ann L Enninga, Wendy K Nevala, Shernan G Holtan, Alexey A Leontovich, Svetomir N Markovic
Galectin-9, a β-galactoside-binding protein, is defined as a negative regulator of T helper 1 (Th1) immune responses, favoring Th2 bias. Systemic immunity in patients with metastatic melanoma is predominantly Th2 biased. We hypothesized that galectin-9 can modulate systemic immunity toward Th2 polarization in patients with advanced melanoma. The presence or concentration of galectin-9 was assessed in tumors and plasma, in patients with metastatic melanoma. The immunomodulatory function of galectin-9 was determined by exposing human peripheral blood mononuclear cells to galectin-9 in vitro...
October 2016: Melanoma Research
Tatsuo Shimura, Masahiko Shibata, Kenji Gonda, Takahiro Nakajima, Shun Chida, Masaru Noda, Satoshi Suzuki, Izumi Nakamura, Shinji Ohki, Seiichi Takenoshita
Galectin-3, a β-galactoside-binding lectin, exhibits pleiotropic biological functions and has a role as one of the immunological modulators. However, the associations between circulating galectin-3 and immunological, inflammatory and nutritional parameters have not yet been fully elucidated. The serum concentration of galectin-3 was examined in association with interleukin-10 (IL-10), IL-12 and IL17 production, lymphocyte stimulation, neutrophil/lymphocyte ratio (NLR), white blood cell count (WBC), C-reactive protein (CRP) and rapid turnover proteins, including retinol-binding protein (RBP), prealbumin (PA) and transferrin (TF) in 50 patients with untreated colorectal cancers...
August 2016: Biomedical Reports
Min-Hui Liu, Chao-Hung Wang, Ai-Fu Chiou, Ning-I Yang, Li-Tang Kuo
OBJECTIVE: This study investigated whether multidisciplinary disease management programs (MDPs) exert the same effects in heart failure (HF) patients across risk levels stratified by galectin-3 (Gal-3) level and what factors are associated with inadequate effectiveness of MDP. METHODS: We used a longitudinal follow-up design based on a previous randomized trial. A total of 355 stabilized hospitalized HF patients were enrolled. The effects of MDP on death and HF-related rehospitalization were analyzed according to Gal-3 levels...
July 21, 2016: Biological Research for Nursing
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