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https://www.readbyqxmd.com/read/29220105/less-fibrosis-in-elderly-subjects-supplemented-with-selenium-and-coenzyme-q10-a-mechanism-behind-reduced-cardiovascular-mortality
#1
Urban Alehagen, Jan Aaseth, Jan Alexander, Erland Svensson, Peter Johansson, Anders Larsson
BACKGROUND: In an intervention study where 221 healthy elderly persons received selenium and coenzyme Q10 as a dietary supplement, and 222 received placebo for 4 years we observed improved cardiac function and reduced cardiovascular mortality. As fibrosis is central in the aging process, we investigated the effect of the intervention on biomarkers of fibrogenic activity in a subanalysis of this intervention study. MATERIAL AND METHODS: In the present subanalysis 122 actively treated individuals and 101 controls, the effect of the treatment on eight biomarkers of fibrogenic activity were assessed...
December 8, 2017: BioFactors
https://www.readbyqxmd.com/read/29217470/safe-and-effective-interferon-beta-gene-therapy-for-the-treatment-of-multiple-sclerosis-by-regulating-biological-activity-through-the-design-of-interferon-beta-galectin-9-fusion-proteins
#2
Atsushi Hamana, Yuki Takahashi, Akane Tanioka, Makiya Nishikawa, Yoshinobu Takakura
Multiple sclerosis (MS) is the most common demyelinating disease. Despite the historical use of interferon-beta (IFN-β) for the treatment of patients with MS, concerns exist regarding the side effects of IFN-β. In this study, we designed a series of novel IFN-β fusion proteins containing galectin-9 (gal-9), which exerts immunosuppressive effects through the binding to its receptor on activated Th1 cells. We hypothesized that these fusion proteins would improve the therapeutic effects and reduce the side effects of IFN-β...
December 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29205636/immune-checkpoint-molecules-soluble-program-death-ligand-1-and-galectin-9-are-increased-in-pregnancy
#3
Elizabeth Ann L Enninga, Susan M Harrington, Douglas J Creedon, Rodrigo Ruano, Svetomir N Markovic, Haidong Dong, Roxana S Dronca
PROBLEM: Pregnancy requires balance between tolerance to the haploidentical fetus and the mother's ability to mount immune responses. There are parallels to this phenomenon that occur in metastatic cancer. We assessed soluble program death ligand-1 soluble PD-L1 (sPD-L1) and galectin-9 in the blood of pregnant women during gestation as these molecules are highly involved in immune suppression during cancer. METHOD OF STUDY: Maternal blood was collected from 30 primigravida women at monthly intervals during pregnancy, delivery and 6-week post-partum...
December 4, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29202955/serum-galectin-9-as-a-noninvasive-biomarker-for-the-detection-of-endometriosis-and-pelvic-pain-or-infertility-related-gynecologic-disorders
#4
Reka Brubel, Attila Bokor, Akos Pohl, Gabriella Krisztina Schilli, Laszlo Szereday, Reka Bacher-Szamuel, Janos Rigo, Beata Polgar
OBJECTIVE: To investigate the usefulness of soluble galectin-9 (Gal-9) in the noninvasive laboratory diagnosis of endometriosis and various gynecologic disorders. DESIGN: Prospective case-control study. SETTING: University medical centers. PATIENT(S): A total of 135 women of reproductive age were involved in the study, 77 endometriosis patients, 28 gynecologic controls, and 30 healthy women. INTERVENTION(S): Diagnostic laparoscopy and collection of tissue biopsies, peritoneal cells, and native peripheral blood from different case groups of gynecology patients and healthy women...
December 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29179486/functional-expression-of-tim-3-on-blasts-and-clinical-impact-of-its-ligand-galectin-9-in-myelodysplastic-syndromes
#5
Toshio Asayama, Hideto Tamura, Mariko Ishibashi, Yasuko Kuribayashi-Hamada, Asaka Onodera-Kondo, Namiko Okuyama, Akiko Yamada, Masumi Shimizu, Keiichi Moriya, Hidemi Takahashi, Koiti Inokuchi
T-cell immunoglobulin mucin-3 (Tim-3), an inhibitory immune checkpoint receptor, is highly expressed on acute myeloid leukemia cells and its ligand galectin-9 is reported to drive leukemic progression by binding with Tim-3. However, it remains unclear whether the Tim-3-galectin-9 pathway is associated with the pathophysiology of myelodysplastic syndromes (MDS). Thus, we investigated the expression and function of Tim-3 and the clinical impact of its ligand galectin-9 in MDS. Tim-3 expression levels on MDS blasts by CD45/side-scatter or CD34/CD45 gating were increased as MDS progressed to the advanced stage...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29177052/biomarkers-of-tubulointerstitial-damage-and-function-in-type-1-diabetes
#6
Ian H de Boer, Xiaoyu Gao, Ionut Bebu, Andrew N Hoofnagle, John M Lachin, Andrew Paterson, Bruce A Perkins, Amy K Saenger, Michael W Steffes, Bernard Zinman, Mark E Molitch
Objective: To evaluate biomarkers of renal tubulointerstitial damage and function in type 1 diabetes with and without diabetic kidney disease. Research design and methods: Cross-sectional case-control study of Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study participants. Cases (N=43) had incident persistent estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 with urinary albumin excretion >300 mg/24 hour...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29167025/decrease-of-galectin-3-in-keratinocytes-a-potential-diagnostic-marker-and-a-critical-contributor-to-the-pathogenesis-of-psoriasis
#7
Zhen-Rui Shi, Guo-Zhen Tan, Cui-Xiang Cao, Yan-Fang Han, Zhen Meng, Xiao-Yong Man, Ze-Xin Jiang, Yu-Ping Zhang, Ning-Ning Dang, Kai-Hua Wei, Ding-Fang Bu, Fu-Tong Liu, Liangchun Wang
Psoriasis-specific proteins dysregulated in keratinocytes and involved in the pathophysiological process of psoriasis remains elusive. We report here that epidermal galectin-3 expression is significantly downregulated in lesional skin, but not in non-lesional skin in psoriasis patients, nor in a group of diseases known as psoriasiform dermatitis clinically and histologically similar to psoriasis. The deficiency of epidermal galectin-3 is sufficient to promote development of psoriatic lesions, as evidenced by more severe skin inflammation in galectin-3 knockout (gal3(-/-)) mice, compared to wild-type mice, after imiquimod treatment, and in skin from gal3(-/-) mice grafted onto wildtype mice...
November 20, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29152608/galectin-3-and-venous-thromboembolism-incidence-the-atherosclerosis-risk-in-communities-aric-study
#8
Oluwaseun E Fashanu, Susan R Heckbert, David Aguilar, Paul N Jensen, Christie M Ballantyne, Saonli Basu, Ron C Hoogeveen, Christopher deFilippi, Mary Cushman, Aaron R Folsom
Background: The inflammatory biomarker galectin-3 contributes to pathologic conditions such as heart failure and stimulates murine thrombogenesis. Its association with venous thromboembolism (VTE) has been sparsely studied. Objectives: To assess the prospective association of plasma galectin-3 and the LGALS3 rs4644 SNP with VTE incidence. Methods: We measured plasma galectin-3 in 9,916 participants in the Atherosclerosis Risk in Communities (ARIC) study cohort in 1996 - 1998 and identified VTEs through 2013...
October 2017: Research and Practice in Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29151961/galectin-1-promotes-tumor-progression-via-nf-%C3%AE%C2%BAb-signaling-pathway-in-epithelial-ovarian-cancer
#9
Le Chen, Ying Yao, Lijuan Sun, Jie Tang
Purpose: We previously reported that Galectin-1 (Gal-1) played a role in epithelial ovarian cancer (EOC) progression. In this study, we aimed to further investigate the association between Gal-1 expression and prognosis in EOC patients and tried to reveal some novel potential mechanisms of Gal-1 in EOC invasion and migration. Materials and Methods: Gal-1 and nucleus NF-κBp65 expression in 109 human epithelial ovarian cancer tissue specimens were evaluated by immunohistochemistry. The Cox model and survival curves were used to investigate the effect of Gal-1 on EOC prognosis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29127350/memory-regulatory-t-cells-increase-only-in-inflammatory-phase-of-chronic-hepatitis-b-infection-and-related-to-galectin-9-tim-3-interaction
#10
Ching-Chih Hu, Wen-Juei Jeng, Yi-Cheng Chen, Jian-He Fang, Chien-Hao Huang, Wei Teng, Yi-Chung Hsieh, Yung-Chang Lin, Rong-Nan Chien, I-Shyan Sheen, Chun-Yen Lin
CD4(+)Foxp3(+) regulatory T cells (Tregs) are the main immune suppressors with subpopulation of inflamed-tissue related memory Tregs (mTregs) and non-related resting Treg (rTregs). Previously, Treg was proposed to be the cause of chronicity of hepatitis B virus (HBV) infection but with controversies. We then investigated the role of mTregs in distinct immune phases of chronic HBV infection, especially the non-inflammatory versus inflammatory phases. It was found mTregs but not rTregs increased only in the inflammatory phase and correlated with serum alanine aminotransferase (ALT) level...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122660/a-potential-role-of-galectin-1-in-promoting-mouse-trophoblast-stem-cell-differentiation
#11
Jia-Li You, Wei Wang, Min-Yue Tang, Ying-Hui Ye, Ai-Xia Liu, Yi-Min Zhu
Galectin-1 is highly expressed in blastocysts and trophoblast giant cells during implantation, and dysregulated galectin-1 is associated with many pregnancy-related abnormalities. Elevated galectin-1 contributes to cancer cells invasion. Here, we found that galectin-1 is expressed in mouse oocytes, preimplantation embryos (all stages), and trophoblast stem (TS) cells. Peak levels of galectin-1 mRNA and protein were detected on day 4 and day 5 after the induction of TS cells differentiation. Overexpression of galectin-1 increased TS cells migration and invasion, whereas knockdown of galectin-1 attenuated these effects...
November 6, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29113148/role-of-galectins-in-lung-cancer
#12
Wei-An Chang, Ming-Ju Tsai, Po-Lin Kuo, Jen-Yu Hung
Lung cancer is the leading cause of cancer-associated mortality worldwide and is also associated with a poor prognosis. As in numerous other types of cancer, galectins have been demonstrated to be involved in the progression of lung cancer. Galectins belong to a superfamily of lectins, which are carbohydrate-binding proteins. There are at least 15 members in the galectin family, however, only galectin-1, -2, -3, -4, -7, -8, -9, -10, -12, and -13 are found in humans. Galectins are able to mediate interactions between cells, including homotypic and heterotypic interactions; they also facilitate the bindings between cells and extracellular matrix components...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29099687/conjugated-bilirubin-upregulates-tim-3-expression-on-cd4-cd25-t-cells-anti-inflammatory-implications-for-hepatitis-a-virus-infection
#13
Jorge L Trujillo-Ochoa, Karla F Corral-Jara, Claudia L Charles-Niño, Arturo Panduro, Nora A Fierro
Bilirubin (BR), a metabolite with increased concentrations in plasma during viral hepatitis, has been recognized as a potential immune-modulator. We recently reported that conjugated BR (CB) augments regulatory T cell (Treg) suppressor activity during acute hepatitis A virus (HAV) infection. However, the mechanisms related to the effects of CB on Treg function in the course of hepatotropic viral diseases have not been elucidated. T cell immunoglobulin domain and mucin domain 3 (TIM-3), via its interactions with galectin-9 (GAL-9), is a receptor associated with enhanced Treg function...
November 3, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29098769/analyzing-epigenetic-control-of-galectin-expression-indicates-silencing-of-galectin-12-by-promoter-methylation-in-colorectal-cancer
#14
Eva-Maria Katzenmaier, Matthias Kloor, Hans-Joachim Gabius, Johannes Gebert, Juergen Kopitz
Galectins, a class of lectins with specificity for ß-galactoside containing glycoconjugates, modulate several cellular processes that are involved in the control of normal cell growth, differentiation, cell-cell, and cell matrix interactions. Pathological alterations of the galectin expression pattern have been implicated in the development and progression of cancer. We therefore analyzed epigenetic mechanisms for control of galectin expression in 9 colorectal cancer (CRC) cell lines. Our data demonstrate that expression of galectins-1, -2, -7, -8, and -9 can be regulated by histone acetylation in CRC cell lines...
November 3, 2017: IUBMB Life
https://www.readbyqxmd.com/read/29038585/tissue-and-plasma-levels-of-galectins-in-patients-with-high-grade-serous-ovarian-carcinoma-as-new-predictive-biomarkers
#15
Marilyne Labrie, Lorenna Oliveira Fernandes De Araujo, Laudine Communal, Anne-Marie Mes-Masson, Yves St-Pierre
Galectins are moving closer to center stage in detecting glycosylation aberration in cancer cells. Here, we have investigated the expression of galectins in ovarian cancer (OC) and examined their potential as biomarkers in tissues and blood plasma samples of high grade serous ovarian carcinoma (HGSC) patients. In tissues, we found that increased protein expression of stromal gal-1 and epithelial gal-8/9 was associated with a poor response to treatment of HGSC patients. Gal-8/9 were both independent predictors of chemoresistance and overall survival (OS), respectively...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29033945/improved-efficacy-of-oral-immunotherapy-using-non-digestible-oligosaccharides-in-a-murine-cow-s-milk-allergy-model-a-potential-role-for-foxp3-regulatory-t-cells
#16
Marlotte M Vonk, Mara A P Diks, Laura Wagenaar, Joost J Smit, Raymond H H Pieters, Johan Garssen, Betty C A M van Esch, Léon M J Knippels
BACKGROUND: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to directly modulate intestinal epithelial and immune cells in addition to acting as prebiotics. AIM: To investigate whether a diet supplemented with plant-derived fructo-oligosaccharides (FOS) supports the efficacy of OIT in a murine cow's milk allergy model and to elucidate the potential mechanisms involved...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29032929/binding-of-triazole-linked-galactosyl-arylsulfonamides-to-galectin-3-affects-trypanosoma-cruzi-cell-invasion
#17
Marcelo Fiori Marchiori, Thalita B Riul, Leandro Oliveira Bortot, Peterson Andrade, Getúlio G Junqueira, Giuseppina Foca, Nunzianna Doti, Menotti Ruvo, Marcelo Dias-Baruffi, Ivone Carvalho, Vanessa Leiria Campo
The synthesis of the O-3 triazole-linked galactosyl arylsulfonamides 1-7 as potential inhibitors of Trypanosoma cruzi cell invasion is described. These target compounds were synthesized by Cu(I)-catalysed azide-alkyne cycloaddition reaction ('click chemistry') between different azide arylsulfonamides and the alkyne-based sugar 3-O-propynyl-βGalOMe. Inhibition assays of T. cruzi cell invasion with compounds 1-7 showed reduced values of infection index (∼20) for compounds 3 and 5, bearing the corresponding 5-methylisoxazole and 2,4-dimethoxypyrimidine groups, which also presented higher binding affinities to galectin-3 (EC50 17-18 μM) in Corning Epic label-free assays...
November 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29028161/effect-of-haemodialysis-and-residual-renal-function-on-serum-levels-of-galectin-3-b-type-natriuretic-peptides-and-cardiac-troponin-t
#18
Matthew A Roberts, Piyush M Srivastava, David L Hare, Francesco L Ierino
AIM: Levels of plasma markers of myocardial fibrosis (galectin-3), stretch (B-type natriuretic peptide (BNP)) and injury (troponin T (TnT)) may be affected by haemodialysis and residual renal function (RRF) in addition to cardiac pathology. We aimed to determine the association of RRF, urine output and haemodialysis itself on clinically important cardiac biomarkers in haemodialysis patients. METHODS: Adult haemodialysis patients underwent venesection pre- and post- haemodialysis followed by echocardiography and inter-dialytic urine collection to calculate RRF (mL/minute/1...
October 13, 2017: Nephrology
https://www.readbyqxmd.com/read/29027155/the-role-of-t-cell-immunoglobulin-mucin-3-and-its-ligand-galectin-9-in-antitumor-immunity-and-cancer-immunotherapy
#19
REVIEW
Riyao Yang, Mien-Chie Hung
Cancer treatment in the past few years has been transformed by a new kind of therapy that targets the immune system instead of the cancer itself to reinvigorate antitumor immunity with astonishing results. However, primary and acquired resistance to this type of treatment, namely immune checkpoint blockade (ICB), continue to counter treatment efficacy. In many cases, resistance has been attributed to defective or chronically enhanced interferon signaling and/or upregulation of alternative immune checkpoints, including T-cell immunoglobulin mucin-3 (Tim-3) and its ligand galactin-9 (Gal-9)...
October 11, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28991189/translational-implication-of-galectin-9-in-the-pathogenesis-and-treatment-of-viral-infection
#20
REVIEW
Jenn-Haung Lai, Shue-Fen Luo, Mei-Yi Wang, Ling-Jun Ho
The interaction between galectin-9 and its receptor, Tim-3, triggers a series of signaling events that regulate immune responses. The expression of galectin-9 has been shown to be increased in a variety of target cells of many different viruses, such as hepatitis C virus (HCV), hepatitis B virus (HBV), herpes simplex virus (HSV), influenza virus, dengue virus (DENV), and human immunodeficiency virus (HIV). This enhanced expression of galectin-9 following viral infection promotes significant changes in the behaviors of the virus-infected cells, and the resulting events tightly correlate with the immunopathogenesis of the viral disease...
October 8, 2017: International Journal of Molecular Sciences
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