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https://www.readbyqxmd.com/read/29924982/a-modified-pectic-polysaccharide-from-turmeric-curcuma-longa-with-antiulcer-effects-via-anti-secretary-mucoprotective-and-il-10-mediated-anti-inflammatory-mechanisms
#1
Harsha Mysore Rajagopal, Srikanta Belagihalli Manjegowda, Chandraprakash Serkad, Shylaja Mallaiah Dharmesh
Antiulcer potency of structurally defined low molecular weight modified pectin from turmeric (MTrPP) including inhibitory effects on H. pylori has been demonstrated previously by us. Given that ulcer is a disorder characterized by inflammatory responses leading to initiation, aggravation and perpetuation of disease conditions, the present study aims to understand the possible anti-inflammatory mechanisms through which MTrPP delivered antiulcer effects. Rats triggered with early phase gastric inflammation (LPS) followed by ulcer induction (swim-stress) were pretreated with MTrPP (150 mg/kg b...
June 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29920290/cell-and-stage-specific-localization-of-galectin-3-a-%C3%AE-galactoside-binding-lectin-in-a-mouse-model-of-experimental-autoimmune-encephalomyelitis
#2
Tetsuya Itabashi, Yasunobu Arima, Daisuke Kamimura, Kotaro Higuchi, Yoshio Bando, Hiromi Takahashi-Iwanaga, Masaaki Murakami, Masahiko Watanabe, Toshihiko Iwanaga, Junko Nio-Kobayashi
Multiple sclerosis (MS) is an autoimmune disease in which pathogenic T cells play an important role, and an experimental autoimmune encephalomyelitis (EAE) is used as an animal model of MS. Galectins are β-galactoside-binding lectins and involved in various physiological and pathological events. Among fifteen members of galectins, galectin-1, -8, and -9 play immunosuppressive roles in MS and EAE; however, the role of galectin-3 (gal-3) is complex and controversial. We examined expression of gal-3 in the spinal cord and nerve roots of EAE mice...
June 16, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29906246/o-glycosylation-mediated-signaling-circuit-drives-metastatic-castration-resistant-prostate-cancer
#3
Sheue-Fen Tzeng, Chin-Hsien Tsai, Tai-Kuang Chao, Yu-Ching Chou, Yu-Chih Yang, Mong-Hsun Tsai, Tai-Lung Cha, Pei-Wen Hsiao
Disseminated castration-resistant prostate cancer (CRPC) is a common disease in men that is characterized by limited survival and resistance to androgen-deprivation therapy. The increase in human epidermal growth factor receptor 2 (HER2) signaling contributes to androgen receptor activity in a subset of patients with CRPC; however, enigmatically, HER2-targeted therapies have demonstrated a lack of efficacy in patients with CRPC. Aberrant glycosylation is a hallmark of cancer and involves key processes that support cancer progression...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29896861/galectin-3-and-st2-as-predictors-of-therapeutic-success-in-high-risk-patients-undergoing-percutaneous-mitral-valve-repair-mitraclip
#4
Oliver Dörr, Claudia Walther, Christoph Liebetrau, Till Keller, Thomas Sommer, Niklas Boeder, Matthias Bayer, Pascal Bauer, Helge Möllmann, Luise Gaede, Christian Troidl, Sandra Voss, Timm Bauer, Christian W Hamm, Holger Nef
BACKGROUND: Percutaneous mitral valve repair (PMVR) is an interventional treatment option in patients with severe mitral regurgitation (MR) who have a high risk for open-heart surgery. Currently, there is limited information about predictors of procedural success after PMVR. Galectin-3 (Gal-3) and ST2 induce fibrotic alterations in severe MR and heart failure. The aim of the present study was to examine the predictive value of Gal-3 and ST2 as specific indicators of therapeutic success in high-risk patients undergoing PMVR...
June 12, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29879846/plasma-galectin-3-and-sonographic-measures-of-carotid-atherosclerosis-in-the-atherosclerosis-risk-in-communities-study
#5
Abayomi Oyenuga, Aaron R Folsom, Oluwaseun Fashanu, David Aguilar, Christie M Ballantyne
Galectin-3 is a β-galactoside-binding lectin that plays a role in the regulation of several conditions that are associated with atherosclerosis. The goal of this cross-sectional study was to assess the association of plasma galectin-3 concentrations with sonographic measures of carotid atherosclerosis in the Atherosclerosis Risk in Communities study. Linear regression was used to determine the difference and 95% confidence intervals (CIs) for carotid intima-media thickness (cIMT) by categorical and continuous representations of galectin-3...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29872358/clean-colorectum-at-diagnostic-colonoscopy-subsequent-detection-of-extracolonic-malignancies-by-plasma-protein-biomarkers
#6
Michael Wilhelmsen, Ib J Christensen, Lars N Jørgensen, Mogens R Madsen, Jesper Vilandt, Thore Hillig, Michael Klærke, Knud T Nielsen, Søren Laurberg, Susan Gawel, Xiaoping Yang, Gerard Davis, Anne Meike Heijboer, Frans Martens, Hans J Nielsen
Introduction: Most of the subjects undergoing diagnostic colonoscopy do not have neoplastic bowel lesions. Potentially, some of the symptoms may therefore be caused by extracolonic malignancy, and subjects with persisting symptoms may need subsequent examinations. Blood-based, cancer-associated biomarkers may aid in directing the examinations for other specific malignant diseases. Methods: EDTA plasma samples available from a previous prospective study of subjects undergoing diagnostic colonoscopy were used for analysis of 18 protein biomarkers...
2018: Biomarkers in Cancer
https://www.readbyqxmd.com/read/29867934/exposure-of-intestinal-epithelial-cells-to-short-and-long-chain-fructo-oligosaccharides-and-cpg-oligodeoxynucleotides-enhances-peanut-specific-t-helper-1-polarization
#7
Simone M Hayen, Henny G Otten, Saskia A Overbeek, André C Knulst, Johan Garssen, Linette E M Willemsen
Background: Non-digestible oligosaccharides promote colonization of beneficial gut bacteria and have direct immunomodulatory effects. Apical exposure of intestinal epithelial cells (IECs) to short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) in a transwell co-culture model enhanced the CpG-induced (TLR-9 ligand) T helper 1 (Th1) phenotype and regulatory IL-10 response of underlying peripheral mononuclear cells (PBMCs) of healthy donors. scGOS is derived from lactose and may pose risks in severe cow's milk allergic patients, and scFOS/lcFOS may be an alternative...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29861319/circulating-galectin-3-is-associated-with-left-atrial-appendage-remodelling-and-thrombus-formation-in-patients-with-atrial-fibrillation
#8
Zhengde Tang, Lefeng Zeng, Yanjun Lin, Zhihua Han, Jun Gu, Changqian Wang, Huili Zhang
BACKGROUND: Left atrial appendage (LAA) is gaining increasing attention in patients with atrial fibrillation (AF) in the context of cardioembolic stroke. Galectin-3 (Gal-3) is a mediator of profibrotic pathways and is associated with an increased incidence of heart failure. However, the role of Gal-3 in LAA remodelling and thrombus formation in AF has not been evaluated. METHODS: This prospective study included 153 consecutive patients with paroxysmal (n=58), persistent (n=55) or permanent (n=40) nonvalvular AF...
May 14, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29849876/work-intensity-low-grade-inflammation-and-oxidative-status-a-comparison-between-office-and-slaughterhouse-workers
#9
Sieglinde Zelzer, Franz Tatzber, Markus Herrmann, Willibald Wonisch, Stefan Rinnerhofer, Michael Kundi, Barbara Obermayer-Pietsch, Tobias Niedrist, Gerhard Cvirn, Georg Wultsch, Harald Mangge
Limited knowledge exists about the impact of physical workload on oxidative stress in different occupational categories. Thus, we aimed to investigate the oxidative and inflammatory status in employees with different physical workloads. We enrolled a total of 79 male subjects, 27 office workers (mean age 38.8 ± 9.1 years) and 52 heavy workers, in a slaughterhouse (mean age 40.8 ± 8.2 years). Fasting blood was drawn from an antecubital vein in the morning of the midweek before an 8-hour or 12-hour work shift...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29846864/over-expression-of-iqgap1-indicates-poor-prognosis-in-head-and-neck-squamous-cell-carcinoma
#10
Cong-Cong Wu, Hao Li, Yao Xiao, Lei-Lei Yang, Lei Chen, Wei-Wei Deng, Lei Wu, Wen-Feng Zhang, Zhi-Jun Sun
IQ-domain GTPase-activating protein 1 (IQGAP1) is associated with the development and progression of many human cancers. We aimed to investigate the expression and clinicopathological significances of IQGAP1 in head and neck squamous cell carcinoma (HNSCC). In this study, immunohistochemical staining of IQGAP1, co-inhibitory immune checkpoint molecules and macrophage markers were performed in human HNSCC samples to analyze the expression and correlation with clinicopathological characteristics. Immunoreactivity of IQGAP1 was also detected in immunocompetent mouse HNSCC tissue...
May 30, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29844236/intestinal-lamina-propria-cd4-t-cells-promote-bactericidal-activity-of-macrophages-via-galectin-9-and-tim-3-interaction-during-salmonella-typhimurium-infection
#11
Xin Yu, Hongru Zhang, Linyan Yu, Meifang Liu, Zengyan Zuo, Qiuju Han, Jian Zhang, Zhigang Tian, Cai Zhang
The intestinal immune system is crucial for protection from pathogenic infection and maintenance of mucosal homeostasis. Here, we studied the intestinal immune microenvironment in a Salmonella typhimurium intestinal infection mouse model. Intestinal lamina propria macrophages are the main effector cells in innate resistance to intracellular microbial pathogens. We found that S. typhimurium infection augmented Tim-3 expression on intestinal lamina propria CD4+ T cells and enhanced galectin-9 expression on F4/80+ CD11b+ macrophages...
May 29, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29781134/response-letter-perplexing-role-of-galectin-9-in-lupus-experimental-models-comment-on-article-by-zeggar-et-al
#12
Jun Wada, Sonia Zeggar
We greatly appreciate Drs. Aditya K Panda and Bidyut K Das for their interests to our work reporting the beneficial effects of the deficiency of Lgals9 in pristine-induced lupus model of BALB/c mice(1). They have focused on the discrepancy of results between ours and recently published publication, repoting the protective effects of the administration of recombinant galectin-9 into BXSB/MpJ and NZB/W F1 mice(2). Since we identified galectin-9 and have been demonstrating the therapeutic efficacy of recombinant galectin-9 in nephrotoxic serum nephritis in Wistar Kyoto rats, diabetic nephropathy in db/db mice, and type 1 diabetes in NOD mice, we initially hypothesized that the deficiency of Lgals9 might cause the exacerbation of lupus or lupus nephritis in pristine-induced lupus model in BALB/c mice and MRL/Mpj-Faslpr /J mice...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29765332/galectin-9-expression-predicts-favorable-clinical-outcome-in-solid-tumors-a-systematic-review-and-meta-analysis
#13
Xiaoxiang Zhou, Lejia Sun, Dan Jing, Gang Xu, Jinmei Zhang, Li Lin, Jingjing Zhao, Zhuoran Yao, Hongfeng Lin
Background and Objective: Galectin-9 (Gal-9) is one of the galectin family members which are known as proteins with β-galactoside-binding affinity. Accumulative evidence suggest that Gal-9 plays multifaceted roles in tumor biology. However, the prognostic significance of Gal-9 in solid cancer patients remains controversial. The objective of the study was to clarify the prognostic significance of Gal-9 in solid tumors via meta-analysis. Methods: We searched PubMed, Embase and the Cochrane library for studies that report the correlation between Gal-9 expression and prognosis or clinicopathological parameters in solid cancer patients from inception to October 2017, with no language restriction...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29760188/depression-in-type-1-diabetes-was-associated-with-high-levels-of-circulating-galectin-3
#14
Eva O Melin, Jonatan Dereke, Maria Thunander, Magnus Hillman
OBJECTIVE: Neuroinflammatory responses are implicated in depression. The aim was to explore whether depression in patients with type 1 diabetes (T1D) was associated with high circulating galectin-3, controlling for metabolic variables, s-creatinine, life style factors, medication, and cardiovascular complications. DESIGN: Cross-sectional. METHODS: Participants were T1D patients (n=283, 56% men, age 18-59 years, diabetes duration ≥1 year)...
May 14, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29732570/cd206-positive-myeloid-cells-bind-galectin-9-and-promote-a-tumor-supportive-microenvironment
#15
Elizabeth Ann L Enninga, Kyriakos Chatzopoulos, John T Butterfield, Shari L Sutor, Alexey A Leontovich, Wendy K Nevala, Thomas J Flotte, Svetomir N Markovic
In patients with metastatic melanoma, high blood levels of galectin-9 are correlated with worse overall survival and a bias towards a Th2 inflammatory state supportive of tumor growth. Although galectin-9 signaling through TIM3 on T cells has been described, less is known about the interaction of galectin-9 with macrophages. We aimed to determine whether galectin-9 is a binding partner of CD206 on macrophages and whether the result of this interaction is tumor-supportive. It was determined that incubation of CD68+ macrophages with galectin-9 or anti-CD206 blocked target binding and that both CD206 and galectin-9 were detected by immunoprecipitation of cell lysates...
May 7, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29729689/immunoexpression-of-progesterone-receptor-epithelial-growth-factor-receptor-and-galectin-3-in-uterine-smooth-muscle-tumors
#16
Mervat M Soltan, Abdelkader Mohammed Albasry, Maha K Eldosouky, Hanan S Abdelhamid
Uterine smooth muscle tumors constitute a spectrum of neoplasms. Diagnosis of leiomyomas (LMs) is usually straight forwards; however, atypical leiomyomas (ALMs) and smooth muscle tumors of uncertain malignant potential (STUMPs) have overlapping features and need to be distinguished from leiomyosarcoma. To evaluate progesterone receptor (PR), epithelial growth factor receptor (EGF-R), and galectin-3 expression in LMs, ALMs, STUMPs, and leiomyosarcomas and to assess their possible role in differentiating those tumors...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29721376/pd-l1-expression-is-regulated-by-both-dna-methylation-and-nf-kb-during-emt-signaling-in-non-small-cell-lung-carcinoma
#17
A Asgarova, K Asgarov, Y Godet, P Peixoto, A Nadaradjane, M Boyer-Guittaut, J Galaine, D Guenat, V Mougey, J Perrard, J R Pallandre, A Bouard, J Balland, C Tirole, O Adotevi, E Hendrick, M Herfs, P F Cartron, C Borg, E Hervouet
Tumor cells, which undergo Epithelial-mesenchymal transition (EMT) acquire increased capacities of proliferation, invasion and have the ability to generate metastases by escaping the immune system during their systemic migration. To escape the immune system, cancer cells may induce tolerance or resist elimination by immune effectors via multiple mechanisms and we hypothesized that EMT may control the expression of immune checkpoint inhibitors, then promoting immune evasion. PD-L1 (programmed cell death ligand 1) but not PD-L2 nor Galectin 9 or Death receptor (DR4, DR5 and Fas) and ligands (FasL and TRAIL) expression was up-regulated during cytokine-driven EMT in a reversible manner...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29702149/the-link-between-bone-microenvironment-and-immune-cells-in-multiple-myeloma-emerging-role-of-cd38
#18
REVIEW
Marina Bolzoni, Denise Toscani, Federica Costa, Emanuela Vicario, Franco Aversa, Nicola Giuliani
The relationship between bone and immune cells is well established both in physiological and pathological conditions. Multiple myeloma (MM) is a plasma cell malignancy characterized by an increase of number and activity of osteoclasts (OCLs) and a decrease of osteoblasts (OBs). These events are responsible for bone lesions of MM patients. OCLs support MM cells survival in vitro and in vivo. Recently, the possible role of OCLs as immunosuppressive cells in the MM BM microenvironment has been underlined. OCLs protect MM cells against T cell-mediated cytotoxicity through the expression of several molecules including programmed death-ligand (PD-L) 1, galectin (Gal) 9, CD200, and indoleamine-2,3-dioxygenase (IDO)...
April 24, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29686545/effects-of-eplerenone-on-markers-of-myocardial-fibrosis-6-minute-walk-distance-and-quality-of-life-in-adults-with-tetralogy-of-fallot-and-complete-transposition-of-the-great-arteries
#19
Sandeep S Sodhi, Tony J Zhang, Rachel McDonald, Vanessa Al Rashida, Nitin Kondapalli, Philip Barger, Philip Ludbrook, Ari M Cedars
Ventricular dysfunction is common among patients with repaired cyanotic congenital heart disease. To date, no pharmacologic intervention has been demonstrated to be beneficial in this setting. To begin addressing this knowledge gap, we conducted a single-center prospective, randomized, open-label pilot study to investigate the effects of eplerenone on serologic markers of collagen turnover and inflammation, 6-minute walk distance, and quality of life in patients with tetralogy of Fallot (TOF) or transposition of the great arteries with a systemic right ventricle (transposition of the great arteries [TGA])...
January 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29678512/galectin-3-is-associated-with-left-ventricular-reverse-remodeling-and-outcome-after-percutaneous-mitral-valve-repair
#20
Christine S Zuern, Niklas Floss, Iris I Mueller, Christian Eick, Martin Duckheim, Johannes Patzelt, Meinrad Gawaz, Andreas E May, Karin A L Mueller
BACKGROUND: Plasma Galectin-3 is a marker of myocardial inflammation and fibrosis, was associated with left ventricular (LV) reverse remodeling after conventional surgical mitral valve repair (MVR) and predicted clinical events in patients undergoing transcatheter aortic valve replacement (TAVR). We aimed to evaluate the association between pre-interventional Galectin-3 levels and (1) reverse LV remodeling and (2) major adverse cardiovascular events (MACE) in patients undergoing percutaneous MVR...
July 15, 2018: International Journal of Cardiology
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