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https://www.readbyqxmd.com/read/29452091/expression-profiles-and-clinical-value-of-plasma-exosomal-tim-3-and-galectin-9-in-non-small-cell-lung-cancer
#1
Jianwei Gao, Xiangyu Qiu, Xinying Li, Hang Fan, Fang Zhang, Tangfeng Lv, Yong Song
Exosomes are membrane-bound, virus-size vesicles present in circulating blood. Tumor cells are avid producers of exosomes, which are thought to mimic molecular features of parent tumor cells. T-cell Immunoglobulin- and Mucin-domain-containing molecule 3 (Tim-3) is one of the next generation immune checkpoints and can be activated by its ligand Galectin-9, negatively regulating anti-tumor immune response. However, the characteristics of plasma exosomal Tim-3/Galectin-9 (Exo-T/G) in cancer remained unknown. Our study aimed to investigate the expression patterns and clinical value of plasma exosomal total protein (Exo-pro) and Exo-T/G in non-small cell lung caner (NSCLC)...
February 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29439091/evaluation-of-galectin-1-and-galectin-3-as-prospective-biomarkers-in-keratoconus
#2
Frans Eberth Costa Andrade, Joyce Luciana Covre, Lisandra Ramos, Rossen Mihaylov Hazarbassanov, Myrna Serapião Dos Santos, Mauro Campos, José Álvaro Pereira Gomes, Cristiane Damas Gil
AIMS: To evaluate the expression of β-galactoside-binding proteins galectin (Gal)-1 and Gal-3 in patients with keratoconus (KC) and postcorneal collagen cross-linking (CXL) treatment in vitro. METHODS: Tear fluid, cornea samples and conjunctival impression cytology specimens from control and KC patients were used to evaluate Gal-1 and Gal-3 expressions. Primary keratocytes were isolated by collagenase digestion from surgically removed corneas of five normal or KC human corneal buttons and cultured in Dulbecco's modified eagle medium/Ham's F12 medium supplemented with 2% fetal bovine serum...
February 8, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29434847/the-relationship-between-cervical-precancerous-lesion-galectin-3-and-p27-protein-expression-and-clinical-prognosis
#3
Jianting Ma, Xingguang Zhang, Gang He, Chunlin Yang
The relationship between galectin-3 and p27kip1 protein expression levels in cervical precancerous lesions and clinical prognosis were studied. A total of 74 patients with cervical intraepithelial neoplasia [(CIN), 20 cases classified as stage I, 24 cases as stage II and 30 cases as stage III] were enrolled in this study. Tissue galectin-3, p27kip1, vascular endothelial growth factor (VEGF)-2 and cyclin D protein levels were detected via immunohistochemical staining and reverse transcription polymerase chain reaction (PCR)...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433546/a-unique-role-for-galectin-9-in-angiogenesis-and-inflammatory-arthritis
#4
Martin J O'Brien, Qiang Shu, W Alexander Stinson, Pei-Suen Tsou, Jeffrey H Ruth, Takeo Isozaki, Phillip L Campbell, Ray A Ohara, Alisa E Koch, David A Fox, M Asif Amin
BACKGROUND: Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid. Roles have been proposed for galectins in the regulation of inflammation and angiogenesis. Therefore, we examined the contribution of Gal-9 to angiogenesis and inflammation in arthritis. METHODS: To determine the role of Gal-9 in angiogenesis, we performed human dermal microvascular endothelial cell (HMVEC) chemotaxis, Matrigel tube formation, and mouse Matrigel plug angiogenesis assays...
February 12, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29429072/an-ex-vivo-ruminal-ovine-model-to-study-the-immediate-immune-response-in-the-context-of-bacterial-lipopolysaccharide
#5
Fathi Abouhajer, Saeed El-Ashram, Musafiri Karama, Shujian Huang, Jian-Feng Liu
We have set up an ex vivo ovine ruminal model, which can mimic the multicellular process to explore the early steps in Salmonella typhimurium lipopolysaccharide (LPS) stimulation using RNA-seq technology. Ovine ruminal explants were collected for histological and transcriptional analysis and supernatants collected to quantitate lactate dehydrogenase (LDH) enzymes. A total of 8 and 523 genes were significantly over-expressed between LPS-treated and control tissues at 6 and 12 h, respectively. However, six and seven hundred and thirteen genes were substantially repressed between the aforementioned tissues, correspondingly...
February 10, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29428936/prognostic-role-of-high-gal-9-expression-in-solid-tumours-a-meta-analysis
#6
Kai Wang, Zhen Chen, Rongzu Wu, Jun Yin, Min Fan, Xianlin Xu
BACKGROUND/AIMS: Recently, many studies have demonstrated that galectin-9 (Gal-9) exhibits altered expression and has a close association with metastasis and recurrence in various cancers. Therefore, we conducted a meta-analysis to assess the prognostic role of Gal-9 expression in solid tumours. METHODS: We searched PubMed, Embase, and Web of Science until June 2017 and identified fourteen eligible studies containing 2,408 patients to include in the meta-analysis...
February 5, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29424570/upregulated-galectin-3-is-not-a-critical-disease-mediator-of-cardiomyopathy-induced-by-%C3%AE-2-adrenoceptor-overexpression
#7
My-Nhan Nguyen, Yidan Su, Helen Kiriazis, Yan Yang, Xiao-Ming Gao, Julie R McMullen, Anthony M Dart, Xiao-Jun Du
Pre-clinical studies have demonstrated that anti-galectin-3 (Gal-3) interventions are effective in attenuating cardiac remodeling, fibrosis and dysfunction. We determined, in a transgenic (TG) mouse model of fibrotic cardiomyopathy, whether galectin-3 expression was elevated and whether Gal-3 played a critical role in disease development. We studied mice with fibrotic cardiomyopathy due to cardiac overexpression of human β2-adrenoceptor (β2-TG). Cardiac expression levels of Gal-3 and fibrotic or inflammatory genes were determined...
February 9, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29417184/galectin-3-is-independently-associated-with-progression-of-nephropathy-in-type-2-diabetes-mellitus
#8
Kathryn C B Tan, Ching-Lung Cheung, Alan C H Lee, Joanne K Y Lam, Ying Wong, Sammy W M Shiu
AIMS/HYPOTHESIS: Galectin-3 has been implicated in cardiac and renal fibrosis and serves as a prognostic clinical indicator in heart failure. The aim of the present study was to evaluate whether serum galectin-3 level is associated with progressive kidney disease in type 2 diabetes. METHODS: Galectin-3 was measured in baseline samples by ELISA in 1320 participants with type 2 diabetes with eGFR ≥30 ml min-1 1.73 m-2. The primary outcome was defined as doubling of serum creatinine and/or initiation of renal replacement therapy during follow-up...
February 7, 2018: Diabetologia
https://www.readbyqxmd.com/read/29415801/bio-profiling-and-bio-prognostication-of-chronic-heart-failure-with-mid-range-ejection-fraction
#9
Pedro Moliner, Josep Lupón, Jaume Barallat, Marta de Antonio, Mar Domingo, Julio Núñez, Elisabet Zamora, Amparo Galán, Javier Santesmases, Cruz Pastor, Antoni Bayes-Genis
BACKGROUND: Recent ESC guidelines on heart failure (HF) have introduced a new phenotype based on left ventricular ejection fraction (LVEF), called the mid-range (HFmrEF). This phenotype falls between the classical reduced (HFrEF) and preserved (HFpEF) HF phenotypes. We aimed to characterize the HFmrEF biomarker profile and outcomes. METHODS: 1069 consecutive ambulatory patients were included in the study (age 66.2 ± 12.8 years); 800 with HFrEF (74.8%), 134 with HFmrEF (12...
January 31, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29389859/role-of-galectins-in-tumors-and-in-clinical-immunotherapy
#10
REVIEW
Feng-Cheng Chou, Heng-Yi Chen, Chih-Chi Kuo, Huey-Kang Sytwu
Galectins are glycan-binding proteins that contain one or two carbohydrate domains and mediate multiple biological functions. By analyzing clinical tumor samples, the abnormal expression of galectins is known to be linked to the development, progression and metastasis of cancers. Galectins also have diverse functions on different immune cells that either promote inflammation or dampen T cell-mediated immune responses, depending on cognate receptors on target cells. Thus, tumor-derived galectins can have bifunctional effects on tumor and immune cells...
February 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29387226/microrna-profiles-during-galectin-9-induced-apoptosis-of-pancreatic-cancer-cells
#11
Ryoichi Okura, Shintaro Fujihara, Hisakazu Iwama, Asahiro Morishita, Taiga Chiyo, Miwako Watanabe, Kayo Hirose, Kiyoyuki Kobayashi, Takayuki Fujimori, Kiyohito Kato, Hideki Kamada, Hideki Kobara, Hirohito Mori, Toshiro Niki, Mitsuomi Hirashima, Keiichi Okano, Yasuyuki Suzuki, Tsutomu Masaki
Pancreatic cancer is the eighth-leading cause of cancer-associated mortality in males and the ninth-leading cause in females worldwide. Even when diagnosed early enough to be potentially resectable, the prognosis of invasive pancreatic cancer is poor. Galectin-9 (Gal-9) is a tandem-repeat type galectin that has recently been demonstrated to possess an anti-proliferative effect on cancer cells. Therefore, the present study evaluated the effects of Gal-9 on the proliferation of human pancreatic cancer cells and examined the microRNAs that are associated with the antitumor effects of Gal-9...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29378529/galectin-1-is-a-poor-prognostic-factor-in-patients-with-glioblastoma-multiforme-after-radiotherapy
#12
Shang-Yu Chou, Shao-Lun Yen, Chao-Cheng Huang, Eng-Yen Huang
BACKGROUND: Galectin-1, a radioresistance marker, was found in our previous study to be a prognostic factor for cervical cancer. The aim of current study is to determine the prognostic significance of the galectin-1 expression level in patients with glioblastoma multiforme (GBM) undergoing adjuvant radiotherapy (RT). METHODS: We included 45 patients with GBM who were treated with maximal safe surgical resection or biopsy alone followed by adjuvant RT of EQD2 (equivalent dose in 2-Gy fractions) > or = 60 Gy for homogeneous treatment...
January 30, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29361803/overall-survival-of-ovarian-cancer-patients-is-determined-by-expression-of-galectins-8-and-9
#13
Heiko Schulz, Christina Kuhn, Simone Hofmann, Doris Mayr, Sven Mahner, Udo Jeschke, Elisa Schmoeckel
The evaluation of new prognostic factors that can be targeted in ovarian cancer diagnosis and therapy is of the utmost importance. Galectins are a family of carbohydrate binding proteins with various implications in cancer biology. In this study, the presence of galectin (Gal)-8 and -9 was investigated in 156 ovarian cancer samples using immunohistochemistry (IHC). Staining was evaluated using semi-quantitative immunoreactivity (IR) scores and correlated to clinical and pathological data. Different types of galectin expression were compared with respect to disease-free survival (DFS) and overall survival (OS)...
January 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29354978/-effects-of-moxibustion-on-treg-th17-cell-and-its-signal-pathway-in-mice-with-rheumatoid-arthritis
#14
Zhidan Liu, Xiaoyan Li, Chuang Zhao, Chunlan Chen, Miao Li, Qian Tan, Ling Zhang, Wei Liang
OBJECTIVE: To observe the effects of moxibustion on Treg/Th17 imbalance and related signal pathway in mice with rheumatoid arthritis (RA), so as to explore the action mechanism of moxibustion on RA. METHODS: Twenty-four DBA/1J male mice were randomly divided into a normal group, a model group, a sham moxibustion group and a moxibustion group, 6 mice in each one. RA model was induced by subcutaneous injection of typeⅡcollagen and adjuvant at tail in mice other than the normal group...
October 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29344243/t-cell-immunoglobulin-and-mucin-domain-containing-protein-3-and-galectin-9-protein-expression-potential-prognostic-significance-in-esophageal-squamous-cell-carcinoma-for-chinese-patients
#15
Nan Hou, Jie Ma, Wei Li, Lingdi Zhao, Quanli Gao, Ling Mai
The aim of the present study was to investigate the expression levels of the T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3) and galectin-9 proteins and their clinical value in esophageal squamous cell carcinoma (ESCC) in Chinese patients. The expression profiles of TIM-3 and galectin-9 in ESCC were determined by the immunohistochemical analysis of the postoperative pathological specimens of 45 patients with ESCC; a χ2 test was used to evaluate the association of TIM-3 and galectin-9 expression with clinicopathological parameters, in addition to univariate and multivariate Cox's proportional hazards model to analyze the prognostic value of the expression of TIM-3 and galectin-9 proteins...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29329315/role-of-n-glycosylation-in-activation-of-prommp-9-a-molecular-dynamics-simulations-study
#16
Sonu Kumar, Piotr Cieplak
Human matrix metalloproteinase proMMP-9 is secreted as latent zymogen, which requires two-steps proteolytic activation. The secreted proMMP-9 is glycosylated at two positions: Asn38 and Asn120 located in the prodomain and catalytic domain, respectively. It has been demonstrated that glycosylation at Asn120 is required for secretion of the enzyme, while the role of Asn38 glycosylation is not well understood, but is usually linked to the activation process. One hypothesis stated that the Asn38 glycosylation might protect against proteolytic activation...
2018: PloS One
https://www.readbyqxmd.com/read/29322198/association-of-cardiovascular-biomarkers-with-incident-heart-failure-with-preserved-and-reduced-ejection-fraction
#17
Rudolf A de Boer, Matthew Nayor, Christopher R deFilippi, Danielle Enserro, Vijeta Bhambhani, Jorge R Kizer, Michael J Blaha, Frank P Brouwers, Mary Cushman, Joao A C Lima, Hossein Bahrami, Pim van der Harst, Thomas J Wang, Ron T Gansevoort, Caroline S Fox, Hanna K Gaggin, Willem J Kop, Kiang Liu, Ramachandran S Vasan, Bruce M Psaty, Douglas S Lee, Hans L Hillege, Traci M Bartz, Emelia J Benjamin, Cheeling Chan, Matthew Allison, Julius M Gardin, James L Januzzi, Sanjiv J Shah, Daniel Levy, David M Herrington, Martin G Larson, Wiek H van Gilst, John S Gottdiener, Alain G Bertoni, Jennifer E Ho
Importance: Nearly half of all patients with heart failure have preserved ejection fraction (HFpEF) as opposed to reduced ejection fraction (HFrEF), yet associations of biomarkers with future heart failure subtype are incompletely understood. Objective: To evaluate the associations of 12 cardiovascular biomarkers with incident HFpEF vs HFrEF among adults from the general population. Design, Setting, and Participants: This study included 4 longitudinal community-based cohorts: the Cardiovascular Health Study (1989-1990; 1992-1993 for supplemental African-American cohort), the Framingham Heart Study (1995-1998), the Multi-Ethnic Study of Atherosclerosis (2000-2002), and the Prevention of Renal and Vascular End-stage Disease study (1997-1998)...
January 10, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29316949/ezh2-promotes-hepatocellular-carcinoma-progression-through-modulating-mir-22-galectin-9-axis
#18
Shaofei Chen, Jiarui Pu, Jie Bai, Yuping Yin, Ke Wu, Jiliang Wang, Xiaoming Shuai, Jinbo Gao, Kaixiong Tao, Guobin Wang, Hang Li
BACKGROUND: Recent studies have shown that interferon-γ (IFN-γ)-induced galectin-9 expression in Kupffer cells plays an essential role in modulatingthe microenvironment of hepatitis-associated hepatocellular carcinoma (HCC). However, whether or not IFN-γ induces galectin-9 expression in HCC cells, its biological role and regulatory mechanism in HCC development and progression are poorly defined. METHODS: Quantitative PCR and western blotting analysis were used to detect galectin-9 and EZH2 levels in HCC cell lines stimulated with IFN-γ...
January 9, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29258207/role-of-galectins-in-multiple-myeloma
#19
REVIEW
Paola Storti, Valentina Marchica, Nicola Giuliani
Galectins are a family of lectins that bind β-galactose-containing glycoconjugates and are characterized by carbohydrate-recognition domains (CRDs). Galectins exploit several biological functions, including angiogenesis, regulation of immune cell activities and cell adhesion, in both physiological and pathological processes, as tumor progression. Multiple myeloma (MM) is a plasma cell (PC) malignancy characterized by the tight adhesion between tumoral PCs and bone marrow (BM) microenvironment, leading to the increase of PC survival and drug resistance, MM-induced neo-angiogenesis, immunosuppression and osteolytic bone lesions...
December 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29250191/galectin-3-rs4652-a-c-polymorphism-is-associated-with-the-risk-of-gastric-carcinoma-and-p-glycoprotein-expression-level
#20
Yi Shi, Xiandong Lin, Gang Chen, Jun Yan, Mingang Ying, Xiongwei Zheng
Galectin-3 serves an important function in cancer development and progression. The present study aimed to explore the association between single nucleotide polymorphisms in galectin-3, and the susceptibility to chemotherapy drug resistance of gastric carcinoma. The present study was a case-control study including 479 patients with gastric carcinoma and 458 cancer-free controls in a population from the Fujian province in Southeast China. Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry was used to determine the genotype of rs4644 and rs4652, and immunohistochemistry was used to identify the expression level of various proteins associated with chemotherapeutic drug resistance...
December 2017: Oncology Letters
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