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https://www.readbyqxmd.com/read/27908893/tracking-monocyte-recruitment-and-macrophage-accumulation-in-atherosclerotic-plaque-progression-using-a-novel-hcd68gfp-apoe-reporter-mouse
#1
Eileen McNeill, Asif J Iqbal, Daniel Jones, Jyoti Patel, Patricia Coutinho, Lewis Taylor, David R Greaves, Keith M Channon
OBJECTIVE: To create a model of atherosclerosis using green fluorescent protein (GFP)-targeted monocytes/macrophages, allowing analysis of both endogenous GFP(+) and adoptively transferred GFP(+) myeloid cells in arterial inflammation. APPROACH AND RESULTS: hCD68GFP reporter mice were crossed with ApoE(-/-) mice. Expression of GFP was localized to macrophages in atherosclerotic plaques and in angiotensin II-induced aortic aneurysms and correlated with galectin 3 and mCD68 expression. Flow cytometry confirmed GFP(+) expression in CD11b(+)/CD64(+), CD11c(+)/MHC-II(HI), and CD11b(+)/F4/80(+) myeloid cells...
December 1, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27900991/increased-expressions-of-plasma-galectin-3-in-patients-with-amyotrophic-lateral-sclerosis
#2
Jun Yan, Yun Xu, Li Zhang, Hui Zhao, Ling Jin, Wei-Guo Liu, Lei-Hua Weng, Zuo-Han Li, Ling Chen
BACKGROUND: High expressions of galectin-3 were identified recently in the end stage of amyotrophic lateral sclerosis (ALS) patients, which suggested that immune reactivity and inflammatory mechanisms might play an important role in the pathogenesis of ALS. The purpose of this study was to investigate plasma galectin-3 levels in different groups and stages of ALS patients and the association with related clinical characteristics. METHODS: A total of 51 patients with ALS and 60 normal controls (NCs) were recruited in this study...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27890770/fibrosis-and-fibrotic-gene-expression-in-pediatric-and-adult-patients-with-idiopathic-dilated-cardiomyopathy
#3
Kathleen C Woulfe, Austine K Siomos, Hieu Nguyen, Megan SooHoo, Csaba Galambo, Brian L Stauffer, Carmen Sucharov, Shelley Miyamoto
BACKGROUND: While fibrosis seems to be prognostic for adverse outcomes in adults with idiopathic dilated cardiomyopathy (IDC), little is known about the prevalence and development of fibrosis in pediatric IDC hearts. We hypothesize there is less activation of fibrosis at a molecular level in pediatric IDC hearts than in the failing adult heart. METHODS AND RESULTS: Pediatric hearts were analyzed histologically to determine the prevalence of fibrosis. Left ventricular tissue from adult and pediatric IDC hearts and adult and pediatric non-failing (NF) hearts were subjected to qRT-PCR to study the expression of important mRNAs that affect fibrosis...
November 24, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27890351/unilaminar-follicular-cells-transiently-express-galectin-3-during-ovarian-folliculogenesis-in-pigs
#4
Seung-Dam Heo, Changnam Park, Jeongtae Kim, Meejung Ahn, Taekyun Shin
The localization of galectin-3, a β-galactoside-binding animal lectin, was immunohistochemically studied in the ovaries of pigs to determine its expression in ovarian folliculogenesis. Various stages of ovarian follicles were identified in the ovaries of adult pigs. Galectin-3 was immunostained in the squamous follicular cells surrounding oocytes in primordial follicles and in the unilaminar granulosa cells of primary follicles, but not in oocytes of multilaminar follicles (including primary, secondary, and tertiary Graafian follicles)...
November 17, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27887661/biochemical-and-proteomic-analyses-of-the-physiological-response-induced-by-individual-housing-in-gilts-provide-new-potential-stress-markers
#5
Anna Marco-Ramell, Laura Arroyo, Raquel Peña, Raquel Pato, Yolanda Saco, Lorenzo Fraile, Emøke Bendixen, Anna Bassols
BACKGROUND: The objective assessment of animal stress and welfare requires proper laboratory biomarkers. In this work, we have analyzed the changes in serum composition in gilts after switching their housing, from pen to individual stalls, which is generally accepted to cause animal discomfort. RESULTS: Blood and saliva samples were collected a day before and up to four days after changing the housing system. Biochemical analyses showed adaptive changes in lipid and protein metabolism after the housing switch, whereas cortisol and muscular markers showed a large variability between animals...
November 25, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27873522/extremely-well-differentiated-papillary-thyroid-carcinoma-resembling-adenomatous-hyperplasia-can-metastasize-to-the-skull-a-case-report
#6
Ju Yeon Pyo, Jisup Kim, Sung Eun Choi, Eunah Shin, Seok Woo Yang, Cheong Soo Park, Seok Mo Kim, Soonwon Hong
We describe herein histologic, immunohistochemical, and molecular findings and clinical manifestations of a rare case of an extremely well differentiated papillary thyroid carcinoma (EWD-PTC). Similarly, it is also difficult to diagnose follicular variant papillary thyroid carcinoma (FVPTC), whose diagnosis is still met with controversy. A recently reported entity of well-differentiated tumor of uncertain malignant potential (WDT-UMP) is added to the diagnostic spectrum harboring EWD-PTC and FVPTC. We report this case, because EWD-PTC is different from FVPTC in its papillary architecture, and also from WDT-UMP in its recurrence and metastatic pattern...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27873468/synthetic-mucin-like-glycopeptides-as-versatile-tools-to-measure-effects-of-glycan-structure-density-position-on-the-interaction-with-adhesion-growth-regulatory-galectins-in-arrays
#7
Gerard Artigas, Hiroshi Hinou, Fayna Garcia-Martin, Hans-Joachim Gabius, Shin-Ichiro Nishimura
Functional pairing of cellular glycoconjugates with tissue lectins is a highly selective process, whose determinative factors have not yet been fully delineated. Glycan structure and modes of presentation, that is, its position and density, can contribute to binding, as different members of a lectin family can regulate degrees of responsiveness to these factors. Using a peptide repeat sequence motif of the glycoprotein mucin-1, the principle of introducing synthetic (glyco)peptides with distinct variations in these three parameters to an array-based screening of tissue lectins is illustrated...
November 21, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27872884/data-on-clinical-characteristics-of-a-heart-failure-patients-cohort-with-reduced-ejection-fraction-and-analysis-of-the-circulating-values-of-five-different-heart-failure-biomarkers-high-sensitivity-troponin-t-galectin-3-c-terminal-propeptide-of-type-i-procollagen
#8
M Batlle, B Campos, M Farrero, M Cardona, B González, M A Castel, J Ortiz, E Roig, M J Pulgarín, J Ramírez, J L Bedini, M Sabaté, P García de Frutos, F Pérez-Villa
In this article, the full description of a heart failure with reduced ejection fraction (HF_REF) cohort of 192 patients is provided. Tables with the baseline demographic, prior history, ECG parameters, echocardiographic parameters, laboratory values and pharmacological treatment of these patients are included. Also, the quartile values of the analyzed circulating biomarkers: high sensitivity Troponin T (hs-TnT), galectin-3 (Gal-3), C-terminal propeptide of type I procollagen (CICP), soluble AXL (sAXL) and Brain Natriuretic Peptide (BNP) are given...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27870162/galectin-3-contributes-to-vascular-fibrosis-in-monocrotaline-induced-pulmonary-arterial-hypertension-rat-model
#9
Xiaoyan Wang, Yanli Wang, Jinbo Zhang, Xue Guan, Minggang Chen, Yumei Li, Li Zhang
Galectin-3 (Gal-3) plays a critical role in vascular inflammation and fibrosis. The role of TGF-β1 in mediating pulmonary vascular fibrosis is well documented; thus, we suspected that Gal-3 could be an important factor in TGF-β1-induced fibrosis in pulmonary adventitial fibroblasts (PAFs). We treated rats with monocrotaline (MCT) and cultured PAFs with TGF-β1 to stimulate fibrosis. We found that MCT injection induced vessel thickening and extracellular matrix deposition in vivo. TGF-β1 stimulated the production of collagen and fibronectin (Fn) protein in vitro...
November 21, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27860389/efficacy-and-safety-of-two-dosages-of-canrenone-as-add-on-therapy-in-hypertensive-patients-taking-ace-inhibitors-or-angiotensin-ii-receptor-blockers-and-hydrochlorothiazide-at-maximum-dosage-in-a-randomized-clinical-trial-the-escape-it-trial
#10
Giuseppe Derosa, Pamela Maffioli, Maria D'Avino, Carla Sala, Amedeo Mugellini, Vito Vulpis, Salvatore Felis, Luigina Guasti, Riccardo Sarzani, Alessandro Bestetti, Massimo Vanasia, Giovanni Gaudio
AIM: To evaluate the effects of canrenone as add-on therapy in patients already treated with angiotensin converting-enzyme inhibitors (ACE-I) or angiotensin II receptor blockers (ARBs) and hydrochlorothiazide at the maximum dosage (25 mg/day). METHOD: In this randomized, open label, controlled trial, we enrolled 175 Caucasian patients with essential hypertension not well controlled by concomitant ACE-I or ARBs and hydrochlorothiazide. At baseline 87 patients (57 males and 30 females) were randomized to add canrenone 50 mg, and 88 (56 males and 32 females) patients to canrenone 100 mg, once a day, for three months...
November 12, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27855339/effect-of-solvent-model-when-probing-protein-dynamics-with-molecular-dynamics
#11
Samuel Genheden
We probe the dynamics of the Bpti and Galectin-3 proteins using molecular dynamics simulations employing three water models at different levels of resolution, viz. the atomistic TIP4P-Ewald, the coarse-grained Elba and an implicit generalised Born model. The dynamics are quantified indirectly by model-free order parameters, S(2) of the backbone NH and selected side-chain bond vectors, which also have been determined experimentally through NMR relaxation measurements. For the backbone, the order parameters produced with the three solvent models agree to a large extent with experiments, giving average unsigned deviations between 0...
November 9, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/27846146/identification-and-validation-of-novel-subtype-specific-protein-biomarkers-in-pancreatic-ductal-adenocarcinoma
#12
Laura Kuhlmann, Wiebke M Nadler, Alexander Kerner, Sabrina A Hanke, Elisa M Noll, Christian Eisen, Elisa Espinet, Vanessa Vogel, Andreas Trumpp, Martin R Sprick, Christoph P Roesli
OBJECTIVES: Pancreatic ductal adenocarcinoma (PDAC) has been subclassified into 3 molecular subtypes: classical, quasi-mesenchymal, and exocrine-like. These subtypes exhibit differences in patient survival and drug resistance to conventional therapies. The aim of the current study is to identify novel subtype-specific protein biomarkers facilitating subtype stratification of patients with PDAC and novel therapy development. METHODS: A set of 12 human patient-derived primary cell lines was used as a starting material for an advanced label-free proteomics approach leading to the identification of novel cell surface and secreted biomarkers...
November 11, 2016: Pancreas
https://www.readbyqxmd.com/read/27836669/genetic-deletion-of-galectin-3-enhances-neuroinflammation-affects-microglial-activation-and-contributes-to-sub-chronic-injury-in-experimental-neonatal-focal-stroke
#13
Sophorn Chip, David Fernández-López, Fan Li, Joel Faustino, Nikita Derugin, Zinaida S Vexler
The pathophysiology of neonatal stroke and adult stroke are distinct in many aspects, including the inflammatory response. We previously showed endogenously protective functions of microglial cells in acute neonatal stroke. We asked if galectin-3 (Gal3), a pleotropic molecule that mediates interactions between microglia/macrophages and the extracellular matrix (ECM), plays a role in early injury after transient middle cerebral occlusion (tMCAO) in postnatal day 10 mice. Compared to wild type (WT) pups, in Gal3 knockout pups injury was worse and cytokine/chemokine production altered, including further increase of MIP1α and MIP1β levels and reduced IL6 levels 72 hours after tMCAO...
November 8, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27835877/o-glycan-sialylation-alters-galectin-3-subcellular-localization-and-decreases-chemotherapy-sensitivity-in-gastric-cancer
#14
Sofia N Santos, Mara S Junqueira, Guilherme Francisco, Manuel Vilanova, Ana Magalhães, Marcelo Dias Baruffi, Roger Chammas, Adrian L Harris, Celso A Reis, Emerson S Bernardes
ST6GalNAc-I, the sialyltransferase responsible for sialyl-Tn (sTn) synthesis, has been previously reported to be positively associated with cancer aggressiveness. Here we describe a novel sTn-dependent mechanism for chemotherapeutic resistance. We show that sTn protects cancer cells against chemotherapeutic-induced cell death by decreasing the interaction of cell surface glycan receptors with galectin-3 and increasing its intracellular accumulation. Moreover, exogenously added galectin-3 potentiated the chemotherapeutics-induced cytotoxicity in sTn non-expressing cells, while sTn overexpressing cells were protected...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27835742/silencing-of-cd40-in%C3%A2-vivo-reduces-progression-of-experimental-atherogenesis-through-an-nf-%C3%AE%C2%BAb-mir-125b-axis-and-reveals-new-potential-mediators-in-the-pathogenesis-of-atherosclerosis
#15
Miguel Hueso, Laura De Ramon, Estanislao Navarro, Elia Ripoll, Josep M Cruzado, Josep M Grinyo, Joan Torras
BACKGROUND AND AIMS: CD40/CD40L signaling exerts a critical role in the development of atherosclerosis, and microRNAs (miRNAs) are key regulators in vascular inflammation and plaque formation. In this work, we investigated mRNA/miRNA expression during progression of atherosclerotic lesions through CD40 silencing. METHODS: We silenced CD40 with a specific siRNA in ApoE(-/-) mice and compared expression of mRNA/miRNA in ascending aorta with scrambled treated mice...
November 2, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27834807/use-of-atomic-force-microscopy-to-study-the-multi-modular-interaction-of-bacterial-adhesins-to-mucins
#16
A Patrick Gunning, Devon Kavanaugh, Elizabeth Thursby, Sabrina Etzold, Donald A MacKenzie, Nathalie Juge
The mucus layer covering the gastrointestinal (GI) epithelium is critical in selecting and maintaining homeostatic interactions with our gut bacteria. However, the molecular details of these interactions are not well understood. Here, we provide mechanistic insights into the adhesion properties of the canonical mucus-binding protein (MUB), a large multi-repeat cell-surface adhesin found in Lactobacillus inhabiting the GI tract. We used atomic force microscopy to unravel the mechanism driving MUB-mediated adhesion to mucins...
November 8, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27833993/galectin-3-in-children-with-chronic-heart-failure-with-normal-and-reduced-ejection-fraction-relationship-to-disease-severity
#17
Alyaa Amal Kotby, Omneya Ibrahim Youssef, Mohamed Omar Elmaraghy, Osama Salah El Sharkawy
Heart failure (HF) progression has not been studied in pediatric patients as well as HF in patients with a normal ejection fraction (HFNEF). We aimed to evaluate galactin-3 in children with HFNEF and reduced ejection fraction (HFREF) and its correlation to disease severity and progression. This cross-sectional study involved 45 chronic HF patients taking G1a (23 HFNEF children) and G1b (22 HFREF children) compared to 45 age- and sex-matched controls (G2) subjected to history taking, Ross functional HF classification, conventional and tissue Doppler echocardiographic systolic and diastolic function assessment (FS%, E/A, S m, E m/A m, E/E m) and laboratory investigations [glomerular filtration rate, serum galactin-3 level (ELISA)]...
November 11, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27833978/primary-squamous-cell-carcinoma-of-the-thyroid-a-case-report
#18
Corina Lichiardopol, Valeriu Şurlin, Maria Camelia Foarfă, Mirela Corina Ghiluşi, Simona Bondari
Primary squamous cell carcinoma of the thyroid is a very rare thyroid malignancy (less than 1% of thyroid cancers) with unfavorable clinical evolution and median survival less than one year, due to highly local tumor invasiveness with airway obstruction, metastases and treatment complications. We present a 62-year-old female patient with a fixed, rapidly increasing 5 cm right thyroid nodule, generating compressive signs and significant weight loss, resembling anaplastic thyroid carcinoma. Thyroid hormones, antithyroid antibodies and calcitonin were normal...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27829990/analysis-of-the-effects-of-preservative-free-tafluprost-on-the-tear-proteome
#19
Sebastian Funke, Sabine Beck, Katrin Lorenz, Marion Kotterer, Dominik Wolters, Natarajan Perumal, Norbert Pfeiffer, Franz H Grus
The purpose of the present study was to assess the ocular surface health status in primary open angle glaucoma (POAG) patients switching from topical application of preserved latanoprost (LT) to preservative-free tafluprost (PFT) by tear proteomic monitoring. Tear fluid of POAG patients showing dry eye symptoms, using LT and switching to PFT as well as tear fluid of healthy controls has been examined. Tear proteome dynamics was monitored over 24 weeks in a first mass spectrometric explorative analysis in a small POAG patient cohort (N = 3)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27829136/gal3-links-inflammation-and-insulin-resistance
#20
Marie Siwicki, Camilla Engblom, Mikael J Pittet
The connection between obesity-induced insulin resistance and inflammation is established, but targeting inflammatory mediators like TNF-α and IL-1β have had limited success improving insulin sensitivity in patients. Now, Li et al. (2016) indicate that galectin-3 could be a targetable link between inflammation and insulin sensitivity.
November 8, 2016: Cell Metabolism
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