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https://www.readbyqxmd.com/read/29153203/galectin-3-in-heart-failure-an-update-of-the-last-3%C3%A2-years
#1
REVIEW
Carolin Gehlken, Navin Suthahar, Wouter C Meijers, Rudolf A de Boer
Galectin-3 plays a role in tissue inflammation, repair, and fibrosis. This article specifically focuses on heart failure (HF), in which galectin-3 has been shown to be a useful biomarker in prognosis and risk stratification, especially in HF with preserved ejection fraction. Experimental research has shown that galectin-3 directly induces pathologic remodeling of the heart, and is therefore considered a culprit protein in the development of cardiac fibrosis in HF, with potentially relevant clinical implications...
January 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29152608/galectin-3-and-venous-thromboembolism-incidence-the-atherosclerosis-risk-in-communities-aric-study
#2
Oluwaseun E Fashanu, Susan R Heckbert, David Aguilar, Paul N Jensen, Christie M Ballantyne, Saonli Basu, Ron C Hoogeveen, Christopher deFilippi, Mary Cushman, Aaron R Folsom
Background: The inflammatory biomarker galectin-3 contributes to pathologic conditions such as heart failure and stimulates murine thrombogenesis. Its association with venous thromboembolism (VTE) has been sparsely studied. Objectives: To assess the prospective association of plasma galectin-3 and the LGALS3 rs4644 SNP with VTE incidence. Methods: We measured plasma galectin-3 in 9,916 participants in the Atherosclerosis Risk in Communities (ARIC) study cohort in 1996 - 1998 and identified VTEs through 2013...
October 2017: Res Pract Thromb Haemost
https://www.readbyqxmd.com/read/29150742/associations-between-nucleus-size-and-immunohistochemical-galectin-3-cytokeratine-19-and-hbme-1-markers-in-thyroid-papillary-carcinoma-a-morphometric-analyze
#3
Hatice Toy, Ozlem Etli, Zeliha Esin Celik, Arsenal Sezgin Alikanoglu
This study aimed to evaluate the morphometric measurements in cases with papillary thyroid carcinoma, and determine a cut-off value to support diagnosis. Fifty cases with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study with their Galectine-3, CK-19 and HBME-1 immunohistochemical staining results. Demographic and clinical data gathered from pathology reports, which included demographic information such as patients' sex, age, macroscopic tumor size, number of tumor focuses; prognostic parameters such as lenfovascular invasion, perineural invasion, thyroid capsule invasion; and results of immunohistochemical CK- 19, Galectin-3 and HBME-1 staining...
November 17, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29141292/-the-difference-expression-and-diagnostic-value-of-rpl5-in-papillary-thyroid-carcinoma-of-children-and-adults
#4
Y Q Jin, S C Wang, J Tai, J Zhang, F Chen, J Shi, Y B Yu, Y R Yang, H M Ren, D Geng, Y H Liu, Y L Guo, X Ni
Objective: To study the difference expression and diagnostic value of ribosomal protein L5 (RPL5) in papillary thyroid carcinoma (PTC) of children and adults. Methods: Realtime-PCR was performed to detect the expression of RPL5 in 22 PTC tissues and 13 pericarcinous tissues. Receiver operating characteristic (ROC) curve and Youden's index were used to evaluate the diagnostic value of RPL5 in PTC of children and adults. Results: The expression of RPL5 in PTC tissues was higher than in pericarcinous tissues. The area under curve (AUC) was 0...
November 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29137980/interaction-of-alpha-synuclein-with-cytogaligin-a-protein-encoded-by-the-proapoptotic-gene-galig
#5
Saïd El Haddad, Amandine Serrano, Thierry Normand, Chloé Robin, Martine Dubois, Fabienne Brule-Morabito, Lucile Mollet, Stéphane Charpentier, Alain Legrand
GALIG, an internal gene to the human galectin-3 gene, encodes two distinct proteins, Mitogaligin and Cytogaligin through translation of a unique mRNA in two overlapping alternative reading frames. When overexpressed GALIG induces apoptosis. In cultured cells, Mitogaligin destabilizes mitochondria membranes through interaction with cardiolipin. Little is known regarding the role of Cytogaligin. This protein displays multiple subcellular localizations; cytosol, nucleus, and mitochondria. We illustrate here that Cytogaligin is also secreted in the extracellular medium...
November 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29136404/galectin-3-expression-is-prognostic-in-diffuse-type-gastric-adenocarcinoma-confers-aggressive-phenotype-and-can-be-targeted-by-yap1-bet-inhibitors
#6
Jaffer A Ajani, Jeannelyn S Estrella, Qiongrong Chen, Arlene M Correa, Lang Ma, Ailing W Scott, Jiankang Jin, Bin Liu, Min Xie, Kazuki Sudo, Hironori Shiozaki, Brian Badgwell, Brian Weston, Jeffrey H Lee, Manoop S Bhutani, Hisashi Onodera, Koyu Suzuki, Akihiro Suzuki, Sheng Ding, Wayne L Hofstetter, Randy L Johnson, Robert S Bresalier, Shumei Song
BACKGROUND: Overexpression of Galectin-3 (Gal-3), a β-galactoside binding protein, has been noted in many tumour types but its functional significance and clinical utility in gastric adenocarcinoma (GAC) are not well known. METHODS: We studied 184 GAC patients characterised by histologic grade, sub-phenotypes (diffuse vs intestinal), and ethnicity (Asians vs North Americans). Immunohistochemistry was performed to assess the expression of Gal-3 in human GACs and we correlated it to the clinical outcomes...
November 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29133191/galectin-3-mediator-of-microglia-responses-in-injured-brain
#7
REVIEW
Reza Rahimian, Louis-Charles Béland, Jasna Kriz
Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function...
November 10, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29132262/diastolic-dysfunction-is-common-in-survivors-of-pediatric-differentiated-thyroid-carcinoma
#8
Mariëlle Sanne Klein Hesselink, Gianni Bocca, Yoran M Hummel, Adrienne H Brouwers, Johannes G M Burgerhof, Eveline W C M van Dam, Jourik A Gietema, Bas Havekes, Marry M van den Heuvel-Eibrink, Eleonora P M Corssmit, Leontien Kremer, Romana Netea-Maier, Helena J H van der Pal, Robin Peeters, John Th M Plukker, Cécile M Ronckers, Hanneke M van Santen, Peter van der Meer, Thera P Links, Wim J E Tissing
INTRODUCTION: Whether pediatric patients with differentiated thyroid carcinoma (DTC) are at risk of developing treatment-related adverse effects on cardiac function is unknown. We therefore studied in long-term survivors of pediatric DTC the prevalence of cardiac dysfunction and atrial fibrillation (AF) in relation to treatment variables, and the association between cardiac dysfunction and plasma biomarkers. PATIENTS AND METHODS: In this nationwide prospective multicenter study, cardiac assessments were performed in 66 adult survivors of pediatric DTC (age at diagnosis ≤18 years and follow-up ≥5 years after diagnosis) treated in The Netherlands between 1970 and 2009...
November 13, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29129812/influence-of-lgals3-gene-polymorphisms-on-susceptibility-and-prognosis-of-dilated-cardiomyopathy-in-a-northern-han-chinese-population
#9
Yuhui Zhang, Yunhong Wang, Mei Zhai, Tianyi Gan, Xuemei Zhao, Rongcheng Zhang, Tao An, Yan Huang, Qiong Zhou, Jian Zhang
BACKGROUND: Galectin-3 plays an important role in modulating cardiac inflammation and fibrosis. It also takes part in the pathways underlying cardiac remodeling. Therefore, LGALS3 gene, encoding galectin-3 protein, is a promising candidate for the genetic study of dilated cardiomyopathy (DCM). To date, there has been no research evaluating the association between LGALS3 gene polymorphisms and the susceptibility and prognosis of DCM. METHODS AND RESULTS: Genotyping of 4 single nucleotide polymorphisms (SNPs) in the LGALS3 gene, which were reported to be functional in the literature, was performed in 279 unrelated clinically diagnosed DCM patients and 363 apparently healthy controls from Northern Han Chinese population using iPLEX SNP Genotyping analysis on a Sequenom MassARRAY System...
November 9, 2017: Gene
https://www.readbyqxmd.com/read/29127350/memory-regulatory-t-cells-increase-only-in-inflammatory-phase-of-chronic-hepatitis-b-infection-and-related-to-galectin-9-tim-3-interaction
#10
Ching-Chih Hu, Wen-Juei Jeng, Yi-Cheng Chen, Jian-He Fang, Chien-Hao Huang, Wei Teng, Yi-Chung Hsieh, Yung-Chang Lin, Rong-Nan Chien, I-Shyan Sheen, Chun-Yen Lin
CD4(+)Foxp3(+) regulatory T cells (Tregs) are the main immune suppressors with subpopulation of inflamed-tissue related memory Tregs (mTregs) and non-related resting Treg (rTregs). Previously, Treg was proposed to be the cause of chronicity of hepatitis B virus (HBV) infection but with controversies. We then investigated the role of mTregs in distinct immune phases of chronic HBV infection, especially the non-inflammatory versus inflammatory phases. It was found mTregs but not rTregs increased only in the inflammatory phase and correlated with serum alanine aminotransferase (ALT) level...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122660/a-potential-role-of-galectin-1-in-promoting-mouse-trophoblast-stem-cell-differentiation
#11
Jia-Li You, Wei Wang, Min-Yue Tang, Ying-Hui Ye, Ai-Xia Liu, Yi-Min Zhu
Galectin-1 is highly expressed in blastocysts and trophoblast giant cells during implantation, and dysregulated galectin-1 is associated with many pregnancy-related abnormalities. Elevated galectin-1 contributes to cancer cells invasion. Here, we found that galectin-1 is expressed in mouse oocytes, preimplantation embryos (all stages), and trophoblast stem (TS) cells. Peak levels of galectin-1 mRNA and protein were detected on day 4 and day 5 after the induction of TS cells differentiation. Overexpression of galectin-1 increased TS cells migration and invasion, whereas knockdown of galectin-1 attenuated these effects...
November 6, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29119229/the-emerging-role-of-galectins-in-high-fatality-cancers
#12
REVIEW
Cherylane Dubé-Delarosbil, Yves St-Pierre
Although we witnessed considerable progress in the prevention and treatment of cancer during the past few decades, a number of cancers remain difficult to treat. The main reasons for this are a lack of effective biomarkers necessary for an early detection and inefficient treatments for cancer that are diagnosed at late stages of the disease. Because of their alarmin-like properties and their protumorigenic role during cancer progression, members of the galectin family are uniquely positioned to provide information that could be used for the exploration of possible avenues for the treatment of high fatality cancer (HFC)...
November 8, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29118378/the-association-between-galectin-3-and-hs-crp-and-the-clinical-outcome-after-non-st-elevation-myocardial-infarction-with-preexisting-atrial-fibrillation
#13
Milan Pavlović, Svetlana Apostolović, Dragana Stokanović, Stefan Momčilović, Tatjana Jevtović-Stoimenov, Snezana Ćirić Zdravković, Sonja Šalinger Martinović, Nebojsa Krstić, Goran Koraćević, Danijela Djordjevic, Vladan Ćosić, Valentina N Nikolic
Increased galectin-3 plasma concentration has been linked to an unfavorable outcome in patients with heart failure or atrial fibrillation (AF). There are no published data about the prognostic utility of galectin-3 and high-sensitivity C-reactive protein (hs-CRP) for long-term clinical outcome in the Non-ST elevation acute myocardial infarction (NSTEMI) patients with preexisting AF. Thirty-two patients with the first acute NSTEMI and preexisting AF and 22 patients without preexisting AF, were prospectively followed for fifteen months...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118031/neurohormonal-blockade-and-circulating-cardiovascular-biomarkers-during-anthracycline-therapy-in-breast-cancer-patients-results-from-the-prada-prevention-of-cardiac-dysfunction-during-adjuvant-breast-cancer-therapy-study
#14
Geeta Gulati, Siri L Heck, Helge Røsjø, Anne H Ree, Pavel Hoffmann, Tor-Arne Hagve, Jon Norseth, Berit Gravdehaug, Kjetil Steine, Jürgen Geisler, Torbjørn Omland
BACKGROUND: Anthracyclines are associated with cardiotoxic effects. Cardiovascular biomarkers may reflect myocardial injury, dysfunction, inflammation, and fibrosis and may precede and predict the development of left ventricular impairment. The aim of this study was to assess: (1) longitudinal change in circulating cardiovascular biomarkers, (2) the effect of metoprolol succinate and candesartan cilexetil on the biomarker response, and (3) the associations between on-treatment changes in biomarker concentrations and subsequent left ventricular dysfunction in patients with early breast cancer receiving anthracyclines...
November 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29113148/role-of-galectins-in-lung-cancer
#15
Wei-An Chang, Ming-Ju Tsai, Po-Lin Kuo, Jen-Yu Hung
Lung cancer is the leading cause of cancer-associated mortality worldwide and is also associated with a poor prognosis. As in numerous other types of cancer, galectins have been demonstrated to be involved in the progression of lung cancer. Galectins belong to a superfamily of lectins, which are carbohydrate-binding proteins. There are at least 15 members in the galectin family, however, only galectin-1, -2, -3, -4, -7, -8, -9, -10, -12, and -13 are found in humans. Galectins are able to mediate interactions between cells, including homotypic and heterotypic interactions; they also facilitate the bindings between cells and extracellular matrix components...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29099687/conjugated-bilirubin-upregulates-tim-3-expression-on-cd4-cd25-t-cells-anti-inflammatory-implications-for-hepatitis-a-virus-infection
#16
Jorge L Trujillo-Ochoa, Karla F Corral-Jara, Claudia L Charles-Niño, Arturo Panduro, Nora A Fierro
Bilirubin (BR), a metabolite with increased concentrations in plasma during viral hepatitis, has been recognized as a potential immune-modulator. We recently reported that conjugated BR (CB) augments regulatory T cell (Treg) suppressor activity during acute hepatitis A virus (HAV) infection. However, the mechanisms related to the effects of CB on Treg function in the course of hepatotropic viral diseases have not been elucidated. T cell immunoglobulin domain and mucin domain 3 (TIM-3), via its interactions with galectin-9 (GAL-9), is a receptor associated with enhanced Treg function...
November 3, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29096716/galectin-1-and-galectin-3-expression-in-equine-mesenchymal-stromal-cells-mscs-synovial-fibroblasts-and-chondrocytes-and-the-effect-of-inflammation-on-msc-motility
#17
Heidi L Reesink, Ryan M Sutton, Carolyn R Shurer, Ryan P Peterson, Julie S Tan, Jin Su, Matthew J Paszek, Alan J Nixon
BACKGROUND: Mesenchymal stromal cells (MSCs) can be used intra-articularly to quell inflammation and promote cartilage healing; however, mechanisms by which MSCs mitigate joint disease remain poorly understood. Galectins, a family of β-galactoside binding proteins, regulate inflammation, adhesion and cell migration in diverse cell types. Galectin-1 and galectin-3 are proposed to be important intra-articular modulators of inflammation in both osteoarthritis and rheumatoid arthritis. Here, we asked whether equine bone marrow-derived MSCs (BMSCs) express higher levels of galectin-1 and -3 relative to synovial fibroblasts and chondrocytes and if an inflammatory environment affects BMSC galectin expression and motility...
November 2, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29096363/a-sensitive-sandwich-type-immunosensor-for-the-detection-of-galectin-3-based-on-n-gnrs-fe-mofs-aunps-nanocomposites-and-a-novel-aupt-methylene-blue-nanorod
#18
Zhiyong Tang, Junlin He, Jun Chen, Yazhen Niu, Yilin Zhao, Yuchan Zhang, Chao Yu
We are presenting an electrochemical immunosensor for the determination of Galectin-3 (Gal-3), a biomarker of heart failure. A glassy carbon electrode (GCE) was modified with a film of a composite made from the N-doped graphene nanoribbons immobilized Fe-based-Metal-organic frameworks deposited with Au nanoparticles (N-GNRs-Fe-MOFs@AuNPs). Primary antibody against Gal-3 (Gal-3-Ab1) was immobilized on the Au nanoparticles on the surface of the modified GCE which then was blocked with bovine serum albumin. Signal amplification is crucial for obtaining low detection limits in biosensors...
October 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29093555/exosomes-derived-from-hiv-1-infected-dcs-mediate-viral-trans-infection-via-fibronectin-and-galectin-3
#19
Rutuja Kulkarni, Anil Prasad
Exosomes are membrane enclosed nano-sized vesicles actively released into the extracellular milieu that can harbor genomic, proteomic and lipid cargos. Functionally, they are shown to regulate cell-cell communication and transmission of pathogens. Though studies have implicated a role for exosomes in HIV-1 pathogenesis, their mechanisms are not well defined. Here, we characterized exosomes derived from uninfected or HIV-1 infected T-cells and DCs. We demonstrate substantial differences in morphological, molecular and biogenesis machinery between exosomes derived from these two immune cell types...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29077153/research-on-clinical-value-of-galectin-3-in-evaluating-the-prognosis-of-acute-heart-failure
#20
T Zhang, B Shao, G-A Liu
OBJECTIVE: To investigate the clinical value of galectin-3 in the prognosis evaluation of acute heart failure. PATIENTS AND METHODS: A total of 316 patients treated in Suzhou Kowloon Hospital were enrolled into this study and followed up for 1 year. Venous blood during the onset was collected for examinations of blood routine, blood biochemistry, N-terminal B-type pro-brain natriuretic peptide (NT-proBNP), galectin-3 and other indexes. Cardiovascular events (CV events) include the re-admission or death due to the recent acute episode of chronic heart failure...
October 2017: European Review for Medical and Pharmacological Sciences
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