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https://www.readbyqxmd.com/read/29577346/the-impact-of-right-ventricular-function-assessed-by-2-dimensional-speckle-tracking-echocardiography-on-early-mortality-in-patients-with-inferior-myocardial-infarction
#1
Batur G Kanar, Mustafa K Tigen, Murat Sunbul, Altug Cincin, Halil Atas, Alper Kepez, Beste Ozben
BACKGROUND: Right ventricular (RV) involvement in inferior myocardial infarction (MI) increases in-hospital morbidity and mortality. HYPOTHESIS: RV systolic dysfunction assessed by 2-dimensional speckle tracking echocardiography (STE) might be a predictor of early mortality in patients with acute inferior MI. METHODS: Eighty-one consecutive patients with acute inferior MI (mean age, 60.8 ± 12.7 years; 18 females) were included. RV myocardial involvement was defined as an elevation >1 mm in V1 or V4 R within 12 hours of symptom onset...
March 25, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29462878/diagnostic-utility-of-high-sensitivity-troponins-for-echocardiographic-markers-of-structural-heart-disease
#2
Tom Kai Ming Wang, Clementina Dugo, Yvonne Gillian, Wynne Yvonne, Semple Heather, Smith Kevin, Cleave Peter, Christiansen Jonathan, To Andrew, Amir Nezar, Tony Scott, Boswell Ross, Gladding Patrick
The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic markers of left ventricular hypertrophy (LVH) and structural heart disease (SHD). Patients undergoing computer gomography (CT) coronary angiogram for low-intermediate risk chest pain and healthy volunteers were recruited. Hs-troponins Singulex I, Abbott I and Roche T and N-terminal pro-brain natriuretic peptide (NT-proBNP) were evaluated in relation to SHD parameters including left ventricular hypertrophy (LVHEcho ) and left atrial enlargement (LAEEcho ) on echocardiography...
February 15, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29302940/determinants-and-outcome-of-decision-making-among-patients-with-severe-aortic-stenosis
#3
Amjad I Hussain, Andreas Auensen, Cathrine Brunborg, Svend Aakhus, Arnt Fiane, Kjell I Pettersen, Lars Gullestad
BACKGROUND AND AIM OF THE STUDY: Aortic valve replacement (AVR) improves survival and quality of life in patients with severe aortic stenosis (AS), but despite clear indications for surgical treatment a significant proportion of patients do not undergo AVR. The study aim was to identify clinical variables associated with the decision to perform AVR, and to assess the prognostic effect of surgery versus medical treatment in patients with severe AS adjusted for significant confounders and effect modifiers...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29281189/influence-of-hyperoxia-on-diastolic-myocardial-and-arterial-endothelial-function
#4
T Wunderlich, N Frey, W Kähler, M Lutz, P Radermacher, S Klapa, I Koch, F Tillmans, J Witte, A Koch
OBJECTIVE: Hyperoxia is known to influence cardiovascular and endothelial function, but it is unknown if there are differences between younger and older persons. The aim of this study was to monitor changes in myocardial diastolic function and flow-mediated dilatation (FMD) in younger and elderly volunteers, before and after exposure to relevant hyperbaric hyperoxia. METHODS: 51 male patients were separated into two groups for this study. Volunteers in Group 1 (n=28, mean age 26 ±6, "juniors") and Group 2 (n=23, mean age 53 ±9, "seniors") received standard HBO₂ protocol (240kPa oxygen)...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29241463/-myocardial-contusion-following-trauma
#5
R T Stolmeijer, H Lameijer
BACKGROUND: Myocardial contusion is a potentially life threatening condition, which should be considered in patients with a compatible thoracic trauma. Guidelines for diagnosis and determination of management are non-existent. CASE DESCRIPTION: A 51-year-old man arrived at the accident and emergency department with thoracic trauma after being knocked down by a bus. A myocardial contusion was diagnosed based on the ECG and elevated high-sensitivity (hs) troponin levels...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28772106/frontal-plane-t-wave-axis-orientation-predicts-coronary-events-findings-from-the-moli-sani-study
#6
Licia Iacoviello, Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Livia Rago, Amalia De Curtis, Deodato Assanelli, Fabio Badilini, Martino Vaglio, Mariarosaria Persichillo, Peter W Macfarlane, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano
BACKGROUND AND AIMS: The orientation of the frontal plane T-wave axis (T axis) is a reliable measure of ventricular repolarisation. We investigated the association between T-axis and the risk of coronary heart disease (CHD), heart failure (HF), atrial fibrillation (AF), stroke and cardiovascular (CVD) mortality. METHODS: A sample of 21,287 Moli-sani participants randomly recruited from the general adult (≥35 y) Italian population, free of CVD disease, were followed for a median of 4...
July 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28683166/multibiomarker-analysis-in-patients-with-acute-myocardial-infarction
#7
Christiana Schernthaner, Michael Lichtenauer, Bernhard Wernly, Vera Paar, Rudin Pistulli, Ilonka Rohm, Christian Jung, Hans-Reiner Figulla, Attila Yilmaz, Janne Cadamuro, Elisabeth Haschke-Becher, John Pernow, Paul Christian Schulze, Uta C Hoppe, Daniel Kretzschmar
BACKGROUND: Novel biomarkers representing different pathobiological pathways and their role in patients with acute myocardial infarction (AMI) were studied. METHODS: We retrospectively analysed serum levels of soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR), heart-type fatty acid-binding protein (H-FABP) and plasma fetuin A in blood of patients with AMI (STEMI, n = 61; NSTEMI, n = 57) compared to controls with excluded coronary artery disease (n = 76)...
July 6, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28669333/biomarkers-in-stable-coronary-artery-disease
#8
REVIEW
Jonas Rusnak, Christian Fastner, Michael Behnes, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin
BACKGROUND: Coronary Artery Disease (CAD) is the most common reason for death in the western hemisphere. Therefore, a well-functioning risk-management has been established over the past decades with uprising interest in 'novel' biomarkers to predict adverse coronary events and detect patients with subclinical CAD. This review will focus on selected biomarkers belonging to the family of inflammatory markers (fibrinogen or hs-CRP) or to the family of lipid-associated markers (Lipoprotein associated PA2 or Lipoprotein a) and organ-specific biomarkers (hs-troponin, Cystatin C or NTproBNP)...
2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28574204/rational-clinical-evaluation-of-suspected-acute-coronary-syndromes-the-value-of-more-information
#9
David G Hancock, Ming-Yu Anthony Chuang, Rebecca Bystrom, Amera Halabi, Rachel Jones, Matthew Horsfall, Louise Cullen, William A Parsonage, Derek P Chew
OBJECTIVE: Many meta-analyses have provided synthesised likelihood ratio data to aid clinical decision-making. However, much less has been published on how to safely combine clinical information in practice. We aimed to explore the benefits and risks of pooling clinical information during the ED assessment of suspected acute coronary syndrome. METHODS: Clinical information on 1776 patients was collected within a randomised trial conducted across five South Australian EDs between July 2011 and March 2013...
December 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28438640/neutralizing-il-6-reduces-heart-injury-by-decreasing-nerve-growth-factor-precursor-in-the-heart-and-hypothalamus-during-rat-cardiopulmonary-bypass
#10
Chi Cheng, Jun-Mei Xu, Tian Yu
AIMS: To investigate whether the expression of nerve growth factor precursor (proNGF) changes during cardiopulmonary bypass (CPB) and whether neutralizing interleukin-6 (IL-6) during CPB has cardiac benefits. MAIN METHODS: Thirty patients undergoing CPB were recruited and their serum proNGF and troponin-I (TNI) were detected. In addition, rats were divided into three groups: CPB group, CPB with cardiac ischemia-reperfusion (IR) group, and a control group. The pre-CPB standard deviation of N-N intervals (SDNN) and post-CPB SDNN were compared...
June 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28283847/increased-plasma-concentrations-of-soluble-st2-independently-predict-mortality-but-not-cardiovascular-events-in-stable-coronary-heart-disease-patients-13-year-follow-up-of-the-karola-study
#11
MULTICENTER STUDY
Vanessa Pfetsch, Veronika Sanin, Andrea Jaensch, Dhayana Dallmeier, Ute Mons, Hermann Brenner, Wolfgang Koenig, Dietrich Rothenbacher
PURPOSE: sST2 (soluble suppression of tumorigenicity 2), a member of the interleukin-1 family, has been suggested to play a role in cardiac remodeling and inflammatory signaling. We assessed the association between sST2 in patients with stable coronary heart disease (CHD) with multiple cardiovascular outcomes and total mortality, simultaneously controlling for a large number of potential confounders. METHODS: Plasma concentrations of sST2 (ELISA, Critical Diagnostics) were measured at baseline in a cohort of 1081 patients...
April 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28105138/clinical-and-angiographic-correlation-of-high-sensitivity-c-reactive-protein-with-acute-st-elevation-myocardial-infarction
#12
Syed Tanveer, Shaheena Banu, Nasimudeen Rehumathbeevi Jabir, Mohd Shahnawaz Khan, Ghulam Md Ashraf, Nanjappa Cholenahally Manjunath, Shams Tabrez
Vascular inflammation and associated ongoing inflammatory responses are considered as the critical culprits in the pathogenesis of acute atherothrombotic events such as acute coronary syndrome (ACS) and myocardial infarction (MI). ST segment elevation myocardial infarction (STEMI) is considered as one of the prominent clinical forms of ACS. Moreover, C-reactive protein (CRP) is an important acute phase prsotein, which may be estimated using high-sensitivity methods (hs-CRP), and its elevated level in body fluids reflects chronic inflammatory status...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28062147/periprocedural-myocardial-infarction-during-percutaneous-coronary-intervention-in-an-academic-tertiary-centre-in-johannesburg
#13
Nqoba Tsabedze, Keir McCutcheon, Lancelot Mkhwanazi, Riaz Garda, Ahmed Vachiat, Rohan Ramjee, Jameel Moosa, Themba Maluleke, Gloria Mukeshimana, Saffiyyah Karolia, Dineo Mpanya, Pravin Manga
BACKGROUND: Percutaneous coronary intervention (PCI) is effective therapy for significant atherosclerotic coronary artery disease. Despite medical and technological advances in PCI, periprocedural myocardial infarction (PMI) remains a common complication. The frequency and factors associated with PMI have been well investigated in the developed world, yet there is a paucity of data from the developing world, especially Sub-Saharan Africa. METHODS: We prospectively enrolled 153 adult patients undergoing PCI at the Charlotte Maxeke Johannesburg Academic Hospital from the 1st of February 2014 to 31st October 2014...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27569438/performance-and-validation-of-a-novel-biomarker-based-stroke-risk-score-for-atrial-fibrillation
#14
RANDOMIZED CONTROLLED TRIAL
Jonas Oldgren, Ziad Hijazi, Johan Lindbäck, John H Alexander, Stuart J Connolly, John W Eikelboom, Michael D Ezekowitz, Christopher B Granger, Elaine M Hylek, Renato D Lopes, Agneta Siegbahn, Salim Yusuf, Lars Wallentin
BACKGROUND: Atrial fibrillation is associated with increased but variable risk of stroke. Our aim was to validate the recently developed biomarker-based ABC (age, biomarkers [high-sensitivity troponin and N-terminal fragment B-type natriuretic peptide], and clinical history of prior stroke/transient ischemic attack)-stroke risk score and compare its performance with the CHA2DS2VASc and ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) risk scores. METHODS: The ABC-stroke score includes age, biomarkers (N-terminal fragment B-type natriuretic peptide and high-sensitivity cardiac troponin), and clinical history (prior stroke)...
November 29, 2016: Circulation
https://www.readbyqxmd.com/read/27540030/prognostic-utility-of-galectin-3-for-recurrent-cardiovascular-events-during-long-term-follow-up-in-patients-with-stable-coronary-heart-disease-results-of-the-karola-study
#15
Henning Jansen, Wolfgang Koenig, Andrea Jaensch, Ute Mons, Lutz P Breitling, Hubert Scharnagl, Tatjana Stojakovic, Heribert Schunkert, Hermann Brenner, Dietrich Rothenbacher
BACKGROUND: Galectin-3 has emerged as a potential useful novel biomarker for heart failure and cardiovascular disease (CVD). However, it remains unclear whether galectin-3 is associated with recurrent cardiovascular events during long-term follow-up of patients with stable coronary heart disease (CHD) after adjustment for multiple established and novel risk factors. METHODS: We measured galectin-3 at baseline in a cohort consisting of 1035 CHD patients and followed them for 13 years to assess a combined CVD end point...
October 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27413037/heart-failure-with-improved-ejection-fraction-clinical-characteristics-correlates-of-recovery-and-survival-results-from-the-valsartan-heart-failure-trial
#16
RANDOMIZED CONTROLLED TRIAL
Viorel G Florea, Thomas S Rector, Inder S Anand, Jay N Cohn
BACKGROUND: Heart failure with recovered or improved ejection fraction (HFiEF) has been proposed as a new category of HF. Whether HFiEF is clinically distinct from HF with persistently reduced ejection fraction remains to be validated. METHODS AND RESULTS: Of the 5010 subjects enrolled in the Valsartan Heart Failure Trial (Val-HeFT), 3519 had a baseline left ventricular EF of <35% and a follow-up echocardiographic assessment of EF at 12 months. Of these, 321 (9...
July 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/26764061/coronary-ct-angiography-for-suspected-acs-in-the-era-of-high-sensitivity-troponins-randomized-multicenter-study
#17
RANDOMIZED CONTROLLED TRIAL
Admir Dedic, Marisa M Lubbers, Jeroen Schaap, Jeronymus Lammers, Evert J Lamfers, Benno J Rensing, Richard L Braam, Hendrik M Nathoe, Johannes C Post, Tim Nielen, Driek Beelen, Marie-Claire le Cocq d'Armandville, Pleunie P M Rood, Carl J Schultz, Adriaan Moelker, Mohamed Ouhlous, Eric Boersma, Koen Nieman
BACKGROUND: It is uncertain whether a diagnostic strategy supplemented by early coronary computed tomography angiography (CCTA) is superior to contemporary standard optimal care (SOC) encompassing high-sensitivity troponin assays (hs-troponins) for patients suspected of acute coronary syndrome (ACS) in the emergency department (ED). OBJECTIVES: This study assessed whether a diagnostic strategy supplemented by early CCTA improves clinical effectiveness compared with contemporary SOC...
January 5, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/26524709/prognostic-value-of-undetectable-hs-troponin-t-in-suspected-acute-coronary-syndrome
#18
RANDOMIZED CONTROLLED TRIAL
Mehrshad Vafaie, Anna Slagman, Martin Möckel, Christian Hamm, Kurt Huber, Christian Müller, Jörn O Vollert, Stefan Blankenberg, Hugo A Katus, Christoph Liebetrau, Evangelos Giannitsis, Julia Searle
BACKGROUND: The search for improved strategies for safe and early discharge of patients with suspected acute coronary syndrome in emergency departments is ongoing. This Biomarkers in Cardiology (BIC)-8 biomarker substudy evaluated the usefulness of high-sensitivity troponin T (hsTnT) below or above the limit of detection (LoD) in low-to-intermediate-risk patients with suspected acute coronary syndrome in the emergency department. METHODS: Patients were categorized into hsTnT ≥ the 99th percentile, between the 99th percentile and LoD, or undetectable hsTnT (<LoD)...
March 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/26476506/hs-troponin-i-followed-by-ct-angiography-improves-acute-coronary-syndrome-risk-stratification-accuracy-and-work-up-in-acute-chest-pain-patients-results-from-romicat-ii-trial
#19
RANDOMIZED CONTROLLED TRIAL
Maros Ferencik, Ting Liu, Thomas Mayrhofer, Stefan B Puchner, Michael T Lu, Pal Maurovich-Horvat, J Hector Pope, Quynh A Truong, James E Udelson, W Frank Peacock, Charles S White, Pamela K Woodard, Jerome L Fleg, John T Nagurney, James L Januzzi, Udo Hoffmann
OBJECTIVES: This study compared diagnostic accuracy of conventional troponin/traditional coronary artery disease (CAD) assessment and highly sensitive troponin (hsTn) I/advanced CAD assessment for acute coronary syndrome (ACS) during the index hospitalization. BACKGROUND: hsTnI and advanced assessment of CAD using coronary computed tomography angiography (CTA) are promising candidates to improve the accuracy of emergency department evaluation of patients with suspected ACS...
November 2015: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/26457775/cardiovascular-risk-stratification-in-hemodialysis-patients-in-the-era-of-highly-sensitive-troponins-should-we-choose-between-hs-troponin-i-and-hs-troponin-t
#20
Anne-Sophie Bargnoux, Nils Kuster, Laure Patrier, Anne-Marie Dupuy, Gaelle Tachon, Francois Maurice, Bouchra Badaoui, Lotfi Chalabi, Stéphanie Badiou, Sebastien Deleuze, Hélène Leray-Moragues, Marion Morena, Bernard Canaud, Jean-Paul Cristol
BACKGROUND: New highly sensitive (hs) assays have challenged the interpretation of cardiac troponins (cTn). The present study was designed to evaluate simultaneously conventional cTnT and cTnI together with their corresponding highly sensitive determinations in stable hemodialysis (HD) patients. Ability of cTn to stratify HD patient risk was assessed. METHODS: A total of 224 stable HD patients was included in this observational study. cTnT and hs-cTnT were measured using Roche cTnT/hs-cTnT assays based on a Cobas e601® analyzer...
April 2016: Clinical Chemistry and Laboratory Medicine: CCLM
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