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Licia Iacoviello, Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Livia Rago, Amalia De Curtis, Deodato Assanelli, Fabio Badilini, Martino Vaglio, Mariarosaria Persichillo, Peter W Macfarlane, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano
BACKGROUND AND AIMS: The orientation of the frontal plane T-wave axis (T axis) is a reliable measure of ventricular repolarisation. We investigated the association between T-axis and the risk of coronary heart disease (CHD), heart failure (HF), atrial fibrillation (AF), stroke and cardiovascular (CVD) mortality. METHODS: A sample of 21,287 Moli-sani participants randomly recruited from the general adult (≥35 y) Italian population, free of CVD disease, were followed for a median of 4...
July 22, 2017: Atherosclerosis
Christiana Schernthaner, Michael Lichtenauer, Bernhard Wernly, Vera Paar, Rudin Pistulli, Ilonka Rohm, Christian Jung, Hans-Reiner Figulla, Attila Yilmaz, Janne Cadamuro, Elisabeth Haschke-Becher, John Pernow, Paul Christian Schulze, Uta C Hoppe, Daniel Kretzschmar
BACKGROUND: Novel biomarkers representing different pathobiological pathways and their role in patients with acute myocardial infarction (AMI) were studied. METHODS: We retrospectively analysed serum levels of soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR), heart-type fatty acid-binding protein (H-FABP) and plasma fetuin A in blood of patients with AMI (STEMI, n = 61; NSTEMI, n = 57) compared to controls with excluded coronary artery disease (n = 76)...
July 6, 2017: European Journal of Clinical Investigation
Jonas Rusnak, Christian Fastner, Michael Behnes, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin
BACKGROUND: Coronary Artery Disease (CAD) is the most common reason for death in the western hemisphere. Therefore, a well-functioning risk-management has been established over the past decades with uprising interest in 'novel' biomarkers to predict adverse coronary events and detect patients with subclinical CAD. This review will focus on selected biomarkers belonging to the family of inflammatory markers (fibrinogen or hs-CRP) or to the family of lipid-associated markers (Lipoprotein associated PA2 or Lipoprotein a) and organ-specific biomarkers (hs-troponin, Cystatin C or NTproBNP)...
2017: Current Pharmaceutical Biotechnology
David G Hancock, Ming-Yu Anthony Chuang, Rebecca Bystrom, Amera Halabi, Rachel Jones, Matthew Horsfall, Louise Cullen, William A Parsonage, Derek P Chew
OBJECTIVE: Many meta-analyses have provided synthesised likelihood ratio data to aid clinical decision-making. However, much less has been published on how to safely combine clinical information in practice. We aimed to explore the benefits and risks of pooling clinical information during the ED assessment of suspected acute coronary syndrome. METHODS: Clinical information on 1776 patients was collected within a randomised trial conducted across five South Australian EDs between July 2011 and March 2013...
June 2, 2017: Emergency Medicine Australasia: EMA
Chi Cheng, Jun-Mei Xu, Tian Yu
AIMS: To investigate whether the expression of nerve growth factor precursor (proNGF) changes during cardiopulmonary bypass (CPB) and whether neutralizing interleukin-6 (IL-6) during CPB has cardiac benefits. MAIN METHODS: Thirty patients undergoing CPB were recruited and their serum proNGF and troponin-I (TNI) were detected. In addition, rats were divided into three groups: CPB group, CPB with cardiac ischemia-reperfusion (IR) group, and a control group. The pre-CPB standard deviation of N-N intervals (SDNN) and post-CPB SDNN were compared...
June 1, 2017: Life Sciences
Vanessa Pfetsch, Veronika Sanin, Andrea Jaensch, Dhayana Dallmeier, Ute Mons, Hermann Brenner, Wolfgang Koenig, Dietrich Rothenbacher
PURPOSE: sST2 (soluble suppression of tumorigenicity 2), a member of the interleukin-1 family, has been suggested to play a role in cardiac remodeling and inflammatory signaling. We assessed the association between sST2 in patients with stable coronary heart disease (CHD) with multiple cardiovascular outcomes and total mortality, simultaneously controlling for a large number of potential confounders. METHODS: Plasma concentrations of sST2 (ELISA, Critical Diagnostics) were measured at baseline in a cohort of 1081 patients...
March 10, 2017: Cardiovascular Drugs and Therapy
Syed Tanveer, Shaheena Banu, Nasimudeen Rehumathbeevi Jabir, Mohd Shahnawaz Khan, Ghulam Md Ashraf, Nanjappa Cholenahally Manjunath, Shams Tabrez
Vascular inflammation and associated ongoing inflammatory responses are considered as the critical culprits in the pathogenesis of acute atherothrombotic events such as acute coronary syndrome (ACS) and myocardial infarction (MI). ST segment elevation myocardial infarction (STEMI) is considered as one of the prominent clinical forms of ACS. Moreover, C-reactive protein (CRP) is an important acute phase prsotein, which may be estimated using high-sensitivity methods (hs-CRP), and its elevated level in body fluids reflects chronic inflammatory status...
December 2016: Experimental and Therapeutic Medicine
Nqoba Tsabedze, Keir McCutcheon, Lancelot Mkhwanazi, Riaz Garda, Ahmed Vachiat, Rohan Ramjee, Jameel Moosa, Themba Maluleke, Gloria Mukeshimana, Saffiyyah Karolia, Dineo Mpanya, Pravin Manga
BACKGROUND: Percutaneous coronary intervention (PCI) is effective therapy for significant atherosclerotic coronary artery disease. Despite medical and technological advances in PCI, periprocedural myocardial infarction (PMI) remains a common complication. The frequency and factors associated with PMI have been well investigated in the developed world, yet there is a paucity of data from the developing world, especially Sub-Saharan Africa. METHODS: We prospectively enrolled 153 adult patients undergoing PCI at the Charlotte Maxeke Johannesburg Academic Hospital from the 1st of February 2014 to 31st October 2014...
March 1, 2017: International Journal of Cardiology
Jonas Oldgren, Ziad Hijazi, Johan Lindbäck, John H Alexander, Stuart J Connolly, John W Eikelboom, Michael D Ezekowitz, Christopher B Granger, Elaine M Hylek, Renato D Lopes, Agneta Siegbahn, Salim Yusuf, Lars Wallentin
BACKGROUND: Atrial fibrillation is associated with increased but variable risk of stroke. Our aim was to validate the recently developed biomarker-based ABC (age, biomarkers [high-sensitivity troponin and N-terminal fragment B-type natriuretic peptide], and clinical history of prior stroke/transient ischemic attack)-stroke risk score and compare its performance with the CHA2DS2VASc and ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) risk scores. METHODS: The ABC-stroke score includes age, biomarkers (N-terminal fragment B-type natriuretic peptide and high-sensitivity cardiac troponin), and clinical history (prior stroke)...
November 29, 2016: Circulation
Henning Jansen, Wolfgang Koenig, Andrea Jaensch, Ute Mons, Lutz P Breitling, Hubert Scharnagl, Tatjana Stojakovic, Heribert Schunkert, Hermann Brenner, Dietrich Rothenbacher
BACKGROUND: Galectin-3 has emerged as a potential useful novel biomarker for heart failure and cardiovascular disease (CVD). However, it remains unclear whether galectin-3 is associated with recurrent cardiovascular events during long-term follow-up of patients with stable coronary heart disease (CHD) after adjustment for multiple established and novel risk factors. METHODS: We measured galectin-3 at baseline in a cohort consisting of 1035 CHD patients and followed them for 13 years to assess a combined CVD end point...
October 2016: Clinical Chemistry
Viorel G Florea, Thomas S Rector, Inder S Anand, Jay N Cohn
BACKGROUND: Heart failure with recovered or improved ejection fraction (HFiEF) has been proposed as a new category of HF. Whether HFiEF is clinically distinct from HF with persistently reduced ejection fraction remains to be validated. METHODS AND RESULTS: Of the 5010 subjects enrolled in the Valsartan Heart Failure Trial (Val-HeFT), 3519 had a baseline left ventricular EF of <35% and a follow-up echocardiographic assessment of EF at 12 months. Of these, 321 (9...
July 2016: Circulation. Heart Failure
Admir Dedic, Marisa M Lubbers, Jeroen Schaap, Jeronymus Lammers, Evert J Lamfers, Benno J Rensing, Richard L Braam, Hendrik M Nathoe, Johannes C Post, Tim Nielen, Driek Beelen, Marie-Claire le Cocq d'Armandville, Pleunie P M Rood, Carl J Schultz, Adriaan Moelker, Mohamed Ouhlous, Eric Boersma, Koen Nieman
BACKGROUND: It is uncertain whether a diagnostic strategy supplemented by early coronary computed tomography angiography (CCTA) is superior to contemporary standard optimal care (SOC) encompassing high-sensitivity troponin assays (hs-troponins) for patients suspected of acute coronary syndrome (ACS) in the emergency department (ED). OBJECTIVES: This study assessed whether a diagnostic strategy supplemented by early CCTA improves clinical effectiveness compared with contemporary SOC...
January 5, 2016: Journal of the American College of Cardiology
Mehrshad Vafaie, Anna Slagman, Martin Möckel, Christian Hamm, Kurt Huber, Christian Müller, Jörn O Vollert, Stefan Blankenberg, Hugo A Katus, Christoph Liebetrau, Evangelos Giannitsis, Julia Searle
BACKGROUND: The search for improved strategies for safe and early discharge of patients with suspected acute coronary syndrome in emergency departments is ongoing. This Biomarkers in Cardiology (BIC)-8 biomarker substudy evaluated the usefulness of high-sensitivity troponin T (hsTnT) below or above the limit of detection (LoD) in low-to-intermediate-risk patients with suspected acute coronary syndrome in the emergency department. METHODS: Patients were categorized into hsTnT ≥ the 99th percentile, between the 99th percentile and LoD, or undetectable hsTnT (<LoD)...
March 2016: American Journal of Medicine
Maros Ferencik, Ting Liu, Thomas Mayrhofer, Stefan B Puchner, Michael T Lu, Pal Maurovich-Horvat, J Hector Pope, Quynh A Truong, James E Udelson, W Frank Peacock, Charles S White, Pamela K Woodard, Jerome L Fleg, John T Nagurney, James L Januzzi, Udo Hoffmann
OBJECTIVES: This study compared diagnostic accuracy of conventional troponin/traditional coronary artery disease (CAD) assessment and highly sensitive troponin (hsTn) I/advanced CAD assessment for acute coronary syndrome (ACS) during the index hospitalization. BACKGROUND: hsTnI and advanced assessment of CAD using coronary computed tomography angiography (CTA) are promising candidates to improve the accuracy of emergency department evaluation of patients with suspected ACS...
November 2015: JACC. Cardiovascular Imaging
Anne-Sophie Bargnoux, Nils Kuster, Laure Patrier, Anne-Marie Dupuy, Gaelle Tachon, Francois Maurice, Bouchra Badaoui, Lotfi Chalabi, Stéphanie Badiou, Sebastien Deleuze, Hélène Leray-Moragues, Marion Morena, Bernard Canaud, Jean-Paul Cristol
BACKGROUND: New highly sensitive (hs) assays have challenged the interpretation of cardiac troponins (cTn). The present study was designed to evaluate simultaneously conventional cTnT and cTnI together with their corresponding highly sensitive determinations in stable hemodialysis (HD) patients. Ability of cTn to stratify HD patient risk was assessed. METHODS: A total of 224 stable HD patients was included in this observational study. cTnT and hs-cTnT were measured using Roche cTnT/hs-cTnT assays based on a Cobas e601® analyzer...
April 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Piotr Musialek, Adam Mazurek, Danuta Jarocha, Lukasz Tekieli, Wojciech Szot, Magdalena Kostkiewicz, R Pawel Banys, Malgorzata Urbanczyk, Andrzej Kadzielski, Mariusz Trystula, Jacek Kijowski, Krzysztof Zmudka, Piotr Podolec, Marcin Majka
INTRODUCTION: In large-animal acute myocardial infarction (AMI) models, Wharton's jelly (umbilical cord matrix) mesenchymal stem cells (WJMSCs) effectively promote angiogenesis and drive functional myocardial regeneration. Human data are lacking. AIM: To evaluate the feasibility and safety of a novel myocardial regeneration strategy using human WJMSCs as a unique, allogenic but immuno-privileged, off-the-shelf cellular therapeutic agent. MATERIAL AND METHODS: The inclusion criterion was first, large (LVEF ≤ 45%, CK-MB > 100 U/l) AMI with successful infarct-related artery primary percutaneous coronary intervention reperfusion (TIMI ≥ 2)...
2015: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Annette Maznyczka, Thomas Kaier, Michael Marber
Chest pain is a common presenting symptom; however, the majority of emergency chest pain admissions are not due to acute myocardial infarction (AMI). AMI can be life threatening and early diagnosis or rule out of AMI might potentially improve morbidity and mortality, as well as reduce time to decision and therefore overall treatment costs. High-sensitivity troponin (hs-troponin) assays have been developed that enable precise quantification of extremely low troponin concentrations. Such hs-troponin assays are recommended in early rule-out protocols for AMI, when measured at presentation and again at 3-6 h...
June 2015: Postgraduate Medical Journal
Alistair S Hall, Saif-El-Dean T Abdel-Rahman, Julian H Barth
No abstract text is available yet for this article.
July 2015: Heart: Official Journal of the British Cardiac Society
S El Messaoudi, C W Wouters, H A van Swieten, P Pickkers, L Noyez, P C Kievit, E J Abbink, A Rasing-Hoogveld, T P Bouw, J G Peters, M J H Coenen, A R T Donders, N P Riksen, G A Rongen
Dipyridamole reduces reperfusion-injury in preclinical trials and may be beneficial in patients undergoing coronary angioplasty, but its effect on patients undergoing coronary artery bypass grafting (CABG) is unknown. We hypothesized that dipyridamole limits myocardial reperfusion-injury in patients undergoing CABG. The trial design was a double-blind trial randomizing between pretreatment with dipyridamole or placebo. In all, 94 patients undergoing elective on-pump CABG were recruited between February 2010 and June 2012...
April 2016: Clinical Pharmacology and Therapeutics
Aslı Demir, Fatma Meric Yılmaz, Cavit Ceylan, Omer Gokhan Doluoglu, Perihan Uçar, Cevdet Züngün, Cigdem Yildirim Guclu, Utku Ünal, Umit Karadeniz, Eren Günertem, Gokhan Lafci, Kerim Çağlı, Ayşegül Özgök
We have investigated the effects of ketamine-based and remifentanil-based anesthetic protocol on perioperative serum cystatin-C levels, and creatinine and/or cystatin-C-based eGFR equations in terms of acute kidney injury in coronary artery bypass graft (CABG) surgery. Using a simple randomization method (coin tossing), patients were divided into the two groups and not-blinded to the anesthetist. Remifentanil-midazolam-propofol or ketamine-midazolam-propofol-based anesthetic regimen was chosen. Different eGFR formulas using creatinine (MDRD, CKD-EPI, Cockrauft Gault); cystatin-C (eGFR1, eGFR2) or a combination of creatinine and cystatin-C (eGFR 3) were used to calculate estimated glomerular filtration rates (eGFRs)...
June 2015: Renal Failure
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