Clarissa Wormsbaecher, Andrea R Hindman, Alex Avendano, Marcos Cortes-Medina, Caitlin E Jones, Andrew Bushman, Lotanna Onua, Claire E Kovalchin, Alina R Murphy, Hannah L Helber, Ali Shapiro, Kyle Voytovitch, Xingyan Kuang, Renan Aguilar-Valenzuela, Jennifer L Leight, Jonathan W Song, Craig J Burd
BACKGROUND: In utero endocrine disruption is linked to increased risk of breast cancer later in life. Despite numerous studies establishing this linkage, the long-term molecular changes that predispose mammary cells to carcinogenic transformation are unknown. Herein, we investigated how endocrine disrupting compounds (EDCs) drive changes within the stroma that can contribute to breast cancer susceptibility. METHODS: We utilized bisphenol A (BPA) as a model of estrogenic endocrine disruption to analyze the long-term consequences in the stroma...
May 5, 2020: Breast Cancer Research: BCR