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diéthylstilbestrol

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https://www.readbyqxmd.com/read/28078498/perinatal-exposure-to-bisphenol-a-or-diethylstilbestrol-increases-the-susceptibility-to-develop-mammary-gland-lesions-after-estrogen-replacement-therapy-in-middle-aged-rats
#1
Ayelen L Gomez, Melisa B Delconte, Gabriela A Altamirano, Lucia Vigezzi, Veronica L Bosquiazzo, Luís F Barbisan, Jorge G Ramos, Enrique H Luque, Mónica Muñoz-de-Toro, Laura Kass
The development of the mammary gland is a hormone-regulated event. Several factors can dysregulate its growth and make the gland more susceptible to cellular transformation. Among these factors, perinatal exposure to xenoestrogens and hormone replacement therapy has been associated with increased risk of developing breast cancer. Here, we assessed the effects induced by estrogen replacement therapy (ERT) in ovariectomized (OVX) middle-aged rats and whether perinatal exposure to diethylstilbestrol (DES) or bisphenol A (BPA) modified these effects in the mammary gland...
January 11, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28064340/impact-of-prenatal-exposure-to-diethylstilbestrol-des-on-psychological-outcome-a-national-survey-of-des-daughters-and-unexposed-controls
#2
Helene Verdoux, Emmanuel Devouche, Michel Tournaire, Anne Levadou
To explore whether prenatal exposure to diethylstilbestrol (DES) is associated with increased risk of poor psychological outcome independently of the occurrence of major somatic complications related to DES exposure. Data on health outcome were collected in women prenatally exposed to DES (n = 2566) and unexposed women (n = 2967) recruited in a French national survey. Women prenatally exposed to DES were 1.7 times more likely to have consulted a mental health specialist compared to unexposed women (adjusted odds ratio = 1...
January 7, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28031325/diethylstilbestrol-activates-catsper-and-disturbs-progesterone-actions-in-human-spermatozoa
#3
Qian-Xing Zou, Zhen Peng, Qing Zhao, Hou-Yang Chen, Yi-Min Cheng, Qing Liu, Yuan-Qiao He, Shi-Qi Weng, Hua-Feng Wang, Tao Wang, Li-Ping Zheng, Tao Luo
STUDY QUESTION: Is diethylstilbestrol (DES), a prototypical endocrine-disrupting chemical (EDC), able to induce physiological changes in human spermatozoa and affect progesterone actions? SUMMARY ANSWER: DES promoted Ca(2+) flux into human spermatozoa by activating the cation channel of sperm (CatSper) and suppressed progesterone-induced Ca(2+) signaling, tyrosine phosphorylation and sperm functions. WHAT IS KNOWN ALREADY: DES significantly impairs the male reproductive system both in fetal and postnatal exposure...
December 28, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27940976/the-diethylstilbestrol-legacy-a-powerful-case-against-intervention-in-uncomplicated-pregnancy
#4
Rebecca Troisi, Elizabeth E Hatch, Linda Titus
No abstract text is available yet for this article.
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27940974/potential-intervention-targets-in-utero-and-early-life-for-prevention-of-hormone-related-cancers
#5
C Mary Schooling, Lauren C Houghton, Mary Beth Terry
Hormone-related cancers have long been thought to be sensitive to exposures during key periods of sexual development, as shown by the vulnerability to such cancers of women exposed to diethylstilbestrol in utero. In addition to evidence from human studies, animal studies using new techniques, such as gene knockout models, suggest that an increasing number of cancers may be hormonally related, including liver, lung, and bladder cancer. Greater understanding of sexual development has also revealed the "mini-puberty" of early infancy as a key period when some sex hormones reach levels similar to those at puberty...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27939984/risk-of-cervical-intra-epithelial-neoplasia-and-invasive-cancer-of-the-cervix-in-des-daughters
#6
J Verloop, F E van Leeuwen, Th J M Helmerhorst, I M C M de Kok, E J M van Erp, H H van Boven, M A Rookus
OBJECTIVE: Women exposed to diethylstilbestrol in utero (DES) have an increased risk of clear cell adenocarcinoma (CCA) of the vagina and cervix, while their risk of non-CCA invasive cervical cancer is still unclear. METHODS: We studied the risk of pre-cancerous (CIN) lesions and non-CCA invasive cervical cancer in a prospective cohort of 12,182 women with self-reported DES exposure followed from 2000 till 2008. We took screening behavior carefully into account...
December 7, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27888484/persulfate-assisted-photodegradation-of-diethylstilbestrol-using-monoclinic-bivo4-under-visible-light-irradiation
#7
Yang Liu, Yongli Zhang, Hongguang Guo, Xin Cheng, Hongwei Liu, Weihong Tang
In this study, the photosynergistic performance of BiVO4 with persulfate (PS) is demonstrated under visible light irradiation for the first time. Diethylstilbestrol (DES) was selected as a reluctant compound, and factors including dosages of PS and catalyst, solution pHs, initial concertration of DES, and inorganic anions were evaluated. The morphology and chemical state of bismuth vanadate (BiVO4) was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive spectrometer (EDS), and ultraviolet-visible (UV-Vis) diffuse reflectance spectroscopy (DRS)...
November 26, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27846407/development-of-an-in-vitro-test-battery-for-the-screening-of-the-receptor-mediated-mechanism-and-the-spindle-poison-mode-of-action-of-estrogenic-compounds
#8
Corinne Quadalti, Cesare Galli, Giovanna Lazzari
The implementation of the REACH regulation has imposed the urgent need of developing alternative testing methods to screen large number of compounds more quickly and at lower costs. In this study, a battery of tests, suitable for reproductive toxicology testing, was developed with the objective of detecting the mechanism of action of estrogenic and xenoestrogenic compounds. With this aim, two compounds known for their estrogenic activity, diethylstilbestrol and 17β-estradiol, were used to set up four different in vitro tests: 1) bovine oocyte in vitro maturation assay, 2) bovine preimplantation embryo in vitro culture assay and 3) MCF-7 and 4) BALB/3T3 cell lines proliferation and cytotoxicity assay, respectively...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27760898/activation-of-g-protein-coupled-estrogen-receptor-1-mimics-but-does-not-mediate-the-anti-proliferative-action-of-estradiol-on-pituitary-lactotrophs-in-primary-culture
#9
Tetsuo Mitsui, Maho Ishida, Michi Izawa, Jun Arita
Estrogen binds to nuclear estrogen receptors (ERs) to modulate transcription of target genes in estrogen-responsive cells. However, recent studies have shown that estrogen also binds to cytoplasmic membrane ERs to modulate protein kinase signaling cascades, leading to non-genomic actions. We investigated whether either nuclear or membrane ERs, including G protein-coupled estrogen receptor 1 (Gper1), mediate the inhibitory action of estrogen on insulin-like growth factor-1 (IGF-1)-induced proliferation of pituitary lactotrophs in primary culture...
October 19, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27733886/structural-chromosome-aberrations-cause-swelling-of-the-nucleus
#10
Kenji Takeshita, Hiroaki I Ogawa, Toshinari Maeda
BACKGROUND: Carcinogens are known to cause swelling of the mammalian cell nucleus. However, the mechanism of the swelling and its toxicological significance have not been fully elucidated. Since nuclear swelling (NS hereafter) has been frequently observed in chromosomal aberration (CA hereafter) tests (in vitro), the relationship between NS and CAs was investigated in this study. RESULTS: In a short-term CA test using the fibroblast CHL cell line, the appearance of NS increased in a dose-dependent manner after exposure to six types of clastogens (mitomycin C, methyl methane sulfonate, 1-methyl-3-nitro-1-nitrosoguanidine, benzo[a]pyrene, cyclophosphamide monohydrate, and 9,10-dimethyl-2-benzanthracene), and a strong correlation was found between NS (%) and CAs (%) at each dosage...
2016: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/27721470/a-transgenic-mouse-model-expressing-an-er%C3%AE-folding-biosensor-reveals-the-effects-of-bisphenol-a-on-estrogen-receptor-signaling
#11
Thillai V Sekar, Kira Foygel, Tarik F Massoud, Sanjiv S Gambhir, Ramasamy Paulmurugan
Estrogen receptor-α (ERα) plays an important role in normal and abnormal physiology of the human reproductive system by interacting with the endogenous ligand estradiol (E2). However, other ligands, either analogous or dissimilar to E2, also bind to ERα. This may create unintentional activation of ER signaling in reproductive tissues that can lead to cancer development. We developed a transgenic mouse model that constitutively expresses a firefly luciferase (FLuc) split reporter complementation biosensor (NFLuc-ER-LBDG521T-CFLuc) to simultaneously evaluate the dynamics and potency of ligands that bind to ERα...
October 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27680022/synthesis-and-basic-evaluation-of-7%C3%AE-3-18-f-fluoropropyl-testosterone-and-7%C3%AE-3-18-f-fluoropropyl-dihydrotestosterone
#12
Mayumi Okamoto, Kyosuke Naka, Kiichi Ishiwata, Isao Shimizu, Jun Toyohara
OBJECTIVE: 7α-Substituted androgen derivatives may have the potential to visualize androgen receptors with positron emission tomography. In the present study, we synthesized fluoropropyl derivatives of 7α-(3-[(18)F]fluoropropyl)-testosterone ([(18)F]7) and 7α-(3-[(18)F]fluoropropyl)-dihydrotestosterone ([(18)F]15), and characterized their in vitro binding, in vivo biodistribution, and performed blocking studies in mature androgen deprived male rats. METHODS: We synthesized [(18)F]7 and [(18)F]15...
September 28, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27677392/estrogenic-compound-profiles-in-an-urbanized-industry-impacted-coastal-bay-and-potential-risk-assessment-by-pollution-indices-and-multivariative-statistical-methods
#13
Zaosheng Wang, Rui Li, Fengchang Wu, Chenglian Feng, Chun Ye, Changzhou Yan
The occurrence and distribution of target estrogenic compounds in a highly urbanized industry-impacted coastal bay were investigated, and contamination profiles were evaluated by estimating total estradiol equivalents (∑EEQs) and risk quotients (RQs). Phenolic compounds were the most abundant xenoestrogens, but seldom showed contribution to the ∑EEQs. The diethylstilbestrol (DES) and 17α-ethinylestradiol (EE2) were the major contributors followed by 17β-estradiol (E2) in comparison with a slight contribution from estrone (E1) and estriol (E3)...
January 15, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27649223/using-fenton-oxidation-to-simultaneously-remove-different-estrogens-from-cow-manure
#14
Minxia Sun, Defu Xu, Yuefei Ji, Juan Liu, Wanting Ling, Shunyao Li, Mindong Chen
The presence of estrogens in livestock excrement has raised concerns about their potential negative influence on animals and the overall food cycle. This is the first investigation to simultaneously remove estrogens, including estriol (E3), bisphenol A (BPA), diethylstilbestrol (DES), estradiol (E2), and ethinyl estradiol (EE2), from cow manure using a Fenton oxidation technique. Based on the residual concentrations and removal efficiency of estrogens, the Fenton oxidation reaction conditions were optimized as follows: a H₂O₂ dosage of 2...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27642556/suppression-of-liver-apo-e-secretion-leads-to-hdl-cholesterol-immaturity-in-rats-administered-ethinylestradiol
#15
Kosuke Yamaguchi, Mariko Ishii, Naoyuki Maeda, Hidetomo Iwano, Hiroshi Yokota
Ethinylestradiol (EE), a main component of the combined oral contraceptive pill, is associated with an increased risk of arterial diseases. However, the toxicity mechanism of EE is poorly understood. In this study, we found that the exposure to EE reduced the serum apolipoprotein E (Apo E) level and high-density lipoprotein (HDL)/cholesterol concentration in adult female rats. Diethylstilbestrol showed the same effects and both reductions were suppressed by coadministration of tamoxifen (TAM). Liver perfusion experiments revealed that the secretion rate of Apo E from the liver was significantly reduced...
September 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27617248/uterine-clear-cell-carcinoma-of-postmenopausal-woman-a-case-report
#16
Soo-Ho Chung, Jung-Woo Park
Endometrial cancer is the most common gynecologic malignancy in developed countries. Clear cell carcinoma typically occurs in the ovaries, and very rarely occurs in the endometrium; it accounts for less than 3% of all endometrial cancers. It is presumed that clear cell carcinomas are of Müllerian duct origin, and an association with exposure to diethylstilbestrol (DES) or other nonsteroidal follicle stimulating hormones has been described. We report a case of a postmenopausal woman who presented with vaginal bleeding without a specific medical history...
August 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/27613106/mammary-gland-evaluation-in-juvenile-toxicity-studies-temporal-developmental-patterns-in-the-male-and-female-harlan-sprague-dawley-rat
#17
Adam J Filgo, Julie F Foley, Samantha Puvanesarajah, Aditi R Borde, Bentley R Midkiff, Casey E Reed, Vesna A Chappell, Lydia B Alexander, Pretish R Borde, Melissa A Troester, Schantel A Hayes Bouknight, Suzanne E Fenton
There are currently no reports describing mammary gland development in the Harlan Sprague-Dawley (HSD) rat, the current strain of choice for National Toxicology Program (NTP) testing. Our goals were to empower the NTP, contract labs, and other researchers in understanding and interpreting chemical effects in this rat strain. To delineate similarities/differences between the female and male mammary gland, data were compiled starting on embryonic day 15.5 through postnatal day 70. Mammary gland whole mounts, histology sections, and immunohistochemically stained tissues for estrogen, progesterone, and androgen receptors were evaluated in both sexes; qualitative and quantitative differences are highlighted using a comprehensive visual timeline...
October 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/27611741/recovery-of-fertility-in-quinestrol-or-diethylstilbestrol-des-treated-mice-implications-for-rodent-management
#18
Ming Liu, Rongcan Luo, Hao Wang, Guangming Cao, Yan-Ling Wang
Fertility control is an alternative strategy to traditional culling for the management of rodent pests. Previous studies have demonstrated that quinestrol is a potential contraceptive for male rodents, but the recovery of fertility in quinestrol-treated rodents has not been evaluated. This study used C57BL/6J mice to evaluate the recovery rate of male fertility after the administration of quinestrol. DES (diethylstilbestrol), a non-steroid estrogenic compound, was used for comparison. Different groups of mice were treated with 1 mg/kg quinestrol, 1 mg/kg DES, or castor oil separately for 7 days...
September 9, 2016: Integrative Zoology
https://www.readbyqxmd.com/read/27590545/thin-metal-organic-frameworks-coatings-by-cathodic-electrodeposition-for-solid-phase-microextraction-and-analysis-of-trace-exogenous-estrogens-in-milk
#19
Hangzhen Lan, Daodong Pan, Yangying Sun, Yuxing Guo, Zhen Wu
Cathodic electrodeposition (CED) has received great attention in metal-organic frameworks (MOFs) synthesis due to its distinguished properties including simplicity, controllability, mild synthesis conditions, and product continuously. Here, we report the fabrication of thin (Et3NH)2Zn3(BDC)4 (E-MOF-5) film coated solid phase microextraction (SPME) fiber by a one-step in situ cathodic electrodeposition strategy. Several etched stainless steel fibers were placed in parallel in order to achieve simultaneously electrochemical polymerization...
September 21, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27553264/endocrine-disrupting-chemicals-and-uterine-fibroids
#20
REVIEW
Tiffany A Katz, Qiwei Yang, Lindsey S Treviño, Cheryl Lyn Walker, Ayman Al-Hendy
Uterine fibroids are the most frequent gynecologic tumor, affecting 70% to 80% of women over their lifetime. Although these tumors are benign, they can cause significant morbidity and may require invasive treatments such as myomectomy and hysterectomy. Many risk factors for these tumors have been identified, including environmental exposures to endocrine-disrupting chemicals (EDCs) such as genistein and diethylstilbestrol. Uterine development may be a particularly sensitive window to environmental exposures, as some perinatal EDC exposures have been shown to increase tumorigenesis in both rodent models and human epidemiologic studies...
September 15, 2016: Fertility and Sterility
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