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diéthylstilbestrol

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https://www.readbyqxmd.com/read/29277915/diethylstilbestrol-regulates-mouse-gubernaculum-testis-cell-proliferation-via-plc-ca2-creb-pathway
#1
Xuan Zhang, Hong-Yan Ping, Jian-Hong Li, Shou-Xin Duan, Xue-Wu Jiang
Recent evidence suggested a positive correlation between environmental estrogens (EEs) and high incidence of abnormalities in male urogenital system, but the mechanism remains unclear. Diethylstilbestrol (DES) is a nonsteroidal synthetic estrogen that disrupts the morphology and proliferation of gubernaculum testis cells, but the underlying mechanism is unclear. In this study, mouse gubernaculum testis cells were pretreated with phospholipase C (PLC) inhibitor U-73122 and then treated with DES. The results demonstrated that U-73122 impaired DES-evoked intracellular Ca2+ mobilization in gubernaculum testis cells and inhibited DES-induced proliferation of gubernaculum testis cells...
December 26, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29276968/icotinib-inhibits-egfr-signaling-and-alleviates-psoriasis-like-symptoms-in-animal-models
#2
Fenlai Tan, Guiqun Yang, Yanping Wang, Haibo Chen, Bo Yu, He Li, Jing Guo, Xiaoling Huang, Yifang Deng, Pengxia Yu, Lieming Ding
To investigate the effects of icotinib hydrochloride and a derivative cream on epidermal growth factor receptor (EGFR) signaling and within animal psoriasis models, respectively. The effect of icotinib on EGFR signaling was examined in HaCaT cells, while its effect on angiogenesis was tested in chick embryo chorioallantoic membranes (CAM). The effectiveness of icotinib in treating psoriasis was tested in three psoriasis models, including diethylstilbestrol-treated mouse vaginal epithelial cells, mouse tail granular cell layer formation, and propranolol-induced psoriasis-like features in guinea pig ear skin...
December 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29275294/effects-of-2-3-bis-4-hydroxyphenyl-propionitrile-on-induction-of-polyovular-follicles-in-the-mouse-ovary
#3
Tomomi Sato, Hannah Kim, Hanako Kakuta, Taisen Iguchi
BACKGROUND/AIM: Neonatal diethylstilbestrol (DES) treatment induces polyovular follicles (PFs), which contain more than two oocytes in a follicle, through estrogen receptor (ER) β, not ERα. 2,3-Bis(4-hydroxyphenyl)-propionitrile (DPN) is a specific ERβ agonist; the effects of neonatal DPN exposure on PF induction and gene expression in the mouse ovary were examined. MATERIALS AND METHODS: Histological analysis and real-time reverse transcription-polymerase chain reaction were performed...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29275177/synergistic-therapeutic-effect-of-diethylstilbestrol-and-cx-4945-in-human-acute-t-lymphocytic-leukemia-cells
#4
Jung-Il Jung, Kyeong-Yong Park, Soon Ae Kim, Jiyeon Kim
Human acute T-lymphocytic leukemia (T-ALL) is one of the most commonly diagnosed hematological disorders, and is characterized by poor prognosis and survival rate. Despite the development of new therapeutic approaches, leukemia treatment options remain limited. In this study, we investigated the immunosuppressive and anti-proliferative effects of the synthetic estrogen diethylstilbestrol (DES), both alone and combined with the casein kinase 2 (CK2) inhibitor CX-4945. Our results indicated that DES induced caspase-dependent apoptosis in a human T-ALL cell line (Jurkat cells), while exerting no significant cytotoxicity in normal peripheral blood mononuclear cells (PBMCs)...
December 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29203863/orai-channels-are-critical-for-receptor-mediated-endocytosis-of-albumin
#5
Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G Nelson, Wenjun Ju, Matthias Kretzler, Stephen L Atkin, Maria F Gomez, Shang-Zhong Xu
Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PTECs and downregulated in patients with DN. Hyperglycemia or blockade of insulin signaling reduces the expression of ORAI1-3. Inhibition of ORAI channels by BTP2 and diethylstilbestrol or silencing of ORAI expression impairs albumin uptake. Transgenic mice expressing a dominant-negative Orai1 mutant (E108Q) increases albuminuria, and in vivo injection of BTP2 exacerbates albuminuria in streptozotocin-induced and Akita diabetic mice...
December 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/29199129/evaluating-estrogenic-and-anti-estrogenic-effect-of-endocrine-disrupting-chemicals-edcs-by-zebrafish-danio-rerio-embryo-based-vitellogenin-1-vtg1-mrna-expression
#6
Minjie Chen, Jie Zhang, Shaochen Pang, Chang Wang, Ling Wang, Yonghua Sun, Maoyong Song, Yong Liang
By measuring the vitellogenin 1 (vtg1) expression through quantitative PCR and in situ hybridization, we used the zebrafish embryo as an in vivo model to access the estrogenic or anti-estrogenic effects of several endocrine disrupting chemicals (EDCs), such as natural estrogen 17β-estradiol (E2), estriol (E3), synthetic hormones including diethylstilbestrol (DES), 4-octyl phenol (OP), bisphenol A (BPA), tamoxifen (TMX) and 3-(2,3-dibromopropyl) isocyanurate (TBC). According to our data, the estrogenic effect of the tested chemicals was ranked as: DES>E2>E3>OP>BPA, which is consistent with various in vivo and in vitro models...
January 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29131032/anti-psoriasis-effects-and-mechanisms-of-%C3%AE-8-quinolinoxy-zinc-phthalocyanine-mediated-photodynamic-therapy
#7
Han-Qing Liu, Ying-Ming Wang, Wan-Fang Li, Chao Li, Zhi-Huan Jiang, Jie Bao, Jin-Feng Wei, Hong-Tao Jin, Ai-Ping Wang
BACKGROUND/AIMS: The aim of this study was to determine the anti-psoriasis effects of α-(8-quinolinoxy) zinc phthalocyanine (ZnPc-F7)-mediated photodynamic therapy (PDT) and to reveal its mechanisms. METHODS: HaCaT cells were used to observe the influence of ZnPc-F7-PDT on cell proliferation in vitro. The in vivo anti-psoriasis effects of ZnPc-F7-PDT were evaluated using a mouse vagina model, a propranolol-induced cavy psoriasis model and an imiquimod (IMQ)-induced nude mouse psoriasis model...
November 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29126512/what-is-an-endocrine-disruptor
#8
Claude Monneret
Endocrine disrupting chemicals (EDCs) and potential EDCs are mostly man-made found in various materials. By interfering with the body's endocrine system, endocrine disruptors produce adverse developmental, reproductive, neurological, and immune effects in humans, abnormal growth patterns and neurodevelopmental delays in children. Thus, diethylstilbestrol (DES) a non-steroidal estrogen, which is regarded as a proof of concept, induces clear cell carcinoma among young women. EDCS may be found in plastic bottles and metal food cans (BPA), medical devices (phthalates), detergents, flame retardants (polybrominated diphenyl ethers), food (BPA), toys (phthalates), cosmetics and drugs (parabens), and pesticides (alkyl phenols such as nonylphenol)...
September 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29124779/prenatal-diethylstilbestrol-exposure-and-cancer-risk-in-women
#9
Rebecca Troisi, Elizabeth E Hatch, Linda Titus, William Strohsnitter, Mitchell H Gail, Dezheng Huo, Ervin Adam, Stanley J Robboy, Marianne Hyer, Robert N Hoover, Julie R Palmer
In the Diethylstilbestrol [DES] Combined Cohort Follow-up, the age- and calendar-year specific standardized incidence ratio [SIR] for clear cell adenocarcinoma [CCA] was 27.6 (95% confidence interval [CI] 7.51-70.6) for the exposed women. The SIR for breast cancer was 1.17 (95% CI 1.01-1.36) and the hazard ratio [HR] adjusted for birth year and cohort for comparison with the unexposed was 1.05 (95% CI 0.79-1.41). The SIR for pancreatic cancer was 2.43 (95% CI 1.21-4.34) and the adjusted HR for comparison with unexposed women was 7...
November 10, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29112330/facile-and-versatile-strategy-to-prepare-magnetic-molecularly-imprinted-particles-based-on-the-coassembly-of-magnetic-nanoparticles-and-amphiphilic-random-copolymers
#10
Lili Zhu, Yuhua Cao, Xinjiong Ni, Aimei You, Guangqun Cao
Magnetic molecularly imprinted polymer nanoparticles for bisphenol A were prepared by coassembling magnetic nanoparticles and amphiphilic random copolymers. Under optimized conditions, bisphenol A as template molecules, magnetic molecularly imprinted polymer particles with regular morphology, small size, good monodispersity and high content of OA-Fe3 O4 were prepared by the coassembly method using P(MMA-co-MAA) with monomer ratio of 9:1. These magnetic molecularly imprinted polymer particles could be rapidly collected by an external magnet within 1 min...
November 7, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29102757/response-of-xenografts-of-developing-human-female-reproductive-tracts-to-the-synthetic-estrogen-diethylstilbestrol
#11
Gerald R Cunha, Takeshi Kurita, Mei Cao, Joel Shen, Stanley J Robboy, Laurence Baskin
Human female fetal reproductive tracts 9.5-22 weeks of gestation were grown for 1 month in ovariectomized athymic adult female mouse hosts that were either untreated or treated continuously with diethylstilbestrol (DES) via subcutaneous pellet. Normal morphogenesis and normal patterns of differentiation marker expression (KRT6, KRT7, KRT8, KRT10, KRT14, KRT19, ESR1, PGR, TP63, RUNX1, ISL1, HOXA11 and α-ACT2) were observed in xenografts grown in untreated hosts and mimicked observations of previously reported (Cunha et al...
October 4, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29069384/a-prospective-cohort-study-of-prenatal-diethylstilbestrol-exposure-and-cardiovascular-disease-risk
#12
Rebecca Troisi, Linda Titus, Elizabeth E Hatch, Julie R Palmer, Dezheng Huo, William C Strohsnitter, Ervin Adam, Winnie Ricker, Marianne Hyer, Robert N Hoover
Purpose: Prenatal exposure to diethylstilbestrol (DES), a prototype endocrine disrupting chemical, is associated with risk of adverse reproductive outcomes and cancer in women. We investigated whether cardiovascular disease (CVD) risk might also be greater in prenatally DES exposed women. Methods: DES exposed (n=3941) and unexposed (n=1705) women participating in the Diethylstilbestrol Combined Cohort Follow-up Study were followed prospectively from 1994-2013. Prenatal DES exposure (or lack of exposure) was documented in the birth record or physician's note...
October 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29035768/uv-photoconversion-of-environmental-oestrogen-diethylstilbestrol-and-its-persistence-in-surface-water-under-sunlight
#13
Bi Xu, Kuixiao Li, Juan Qiao, Zhiqi Liungai, Chao Chen, Yun Lu
As one of the most oestrogenic synthetic compounds in water environment, diethylstilbestrol (DES) has been studied for decades. Some studies showed that DES can be removed by ultraviolet (UV) irradiation. However, no one has paid attention to the formation of oestrogenic disinfection by-products (DBPs) and the persistence of DES in surface water remains a mystery. In this study, UV was found to be very effective in removing oestrogenic activity regardless of water quality. Three oestrogenic DBPs were specifically isolated by oestrogen receptor-based affinity chromatography and identified as 9,10-diethylphenanthrene-3,6-diol, cis-DES and Z,Z-dienestrol...
October 3, 2017: Water Research
https://www.readbyqxmd.com/read/29031189/renal-subcapsular-xenografing-of-human-fetal-external-genital-tissue-a-new-model-for-investigating-urethral-development
#14
Dylan Isaacson, Joel Shen, Mei Cao, Adriane Sinclair, Xuan Yue, Gerald Cunha, Laurence Baskin
In this paper, we introduce our novel renal subcapsular xenograft model for the study of human penile urethral and clitoral development. We grafted fifteen intact fetal penes and clitorides 8-11 weeks fetal age under the renal capsules of gonadectomized athymic mice. The mice were treated with a subcutaneous pellet of dihydrotestosterone (DHT), diethylstilbestrol (DES) or untreated with hormones. Xenografts were harvested after fourteen days of growth and analyzed via serial histologic sectioning and immunostaining for Ki-67, cytokeratins 6, 7 and 10, uroplakin and the androgen receptor...
September 22, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29030156/applicability-of-an-innovative-steroid-profiling-method-to-determine-synthetic-growth-promoter-abuse-in-cattle
#15
M H Blokland, E F van Tricht, L A van Ginkel, S S Sterk
A robust LC-MS/MS method was developed to quantify a large number of phase I and phase II steroids in urine. The decision limit is for most compounds lower than 1ngml(-1) with a measurement uncertainty smaller than 30%. The method is fully validated and was applied to assess the influence of administered synthetic steroids and beta-agonists on the steroidogenesis. From three animal experiments, clenbuterol, diethylstilbestrol and stanozolol, the steroid profiles in urine of bovine animals were compared before and after treatment...
November 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28960386/diethylstilbestrol-impaired-oogenesis-of-yellow-catfish-juveniles-through-disrupting-hypothalamic-pituitary-gonadal-axis-and-germ-cell-development
#16
Yaqin Wang, Yingwen Li, Qiliang Chen, Zhihao Liu
Diethylstilbestrol (DES), a non-steroidal estrogen, has been found to cause altered germ cell development and disordered ovarian development in fish females. However, the mechanisms that might be involved are poorly understood. In this study, female juveniles of yellow catfish (Pelteobagrus fulvidraco) (120 days post-hatching) were exposed to two doses (10 and 100 ng l(-1) ) of DES for 28 days. After the endpoint of exposure, decreased ovary weight and gonadosomatic index, as well as various ovarian impairments were observed in response to DES...
September 28, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28927721/agonistic-effects-of-diverse-xenobiotics-on-the-constitutive-androstane-receptor-as-detected-in-a-recombinant-yeast-cell-assay
#17
Ryo Kamata, Daisuke Nakajima, Fujio Shiraishi
The constitutive androstane receptor (CAR) is a nuclear receptor and transcription factor regulating proteins involved in xenobiotic metabolism. Agonist activation of the CAR can trigger metabolic activation and toxification as well as detoxification and clearance; accordingly, xenobiotic substances acting as CAR ligands may pose a threat to human and animal health. We used yeast cells transduced with the human CAR and the response pathway to measure the CAR-agonistic activities of 549 synthetic or natural compounds: 216 of the tested compounds exhibited CAR-agonistic effects...
September 18, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28925019/inclusion-of-pregnant-and-breastfeeding-women-in-research-efforts-and-initiatives
#18
Sílvia M Illamola, Christina Bucci-Rechtweg, Maged M Costantine, Ekaterini Tsilou, Catherine M Sherwin, Anne Zajicek
Pregnant and breastfeeding women have been rendered therapeutic orphans as they have been historically excluded from clinical trials. Labelling for most approved drugs does not provide information about safety and efficacy during pregnancy. This lack of data is mainly due to ethico-legal challenges that have remained entrenched in the post-diethylstilbestrol and thalidomide era, and that have led to pregnancy being viewed in the clinical trial setting primarily through a pharmacovigilance lens. Policy considerations that encourage and/or require the inclusion of pregnant or lactating women in clinical trials may address the current lack of available information...
September 19, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28836296/enzyme-assisted-metal-organic-framework-sensing-system-for-diethylstilbestrol-detection
#19
Wen-Juan Li, Lan Chang, Qiao Liu, Di Ning, Xi-Yuan Yao, Yue Li, Wen-Juan Ruan
As novel fluorescent-sensing materials, metal-organic frameworks (MOFs) have shown great potential in environmental monitoring. However, most of the researches are limited to traditional pollutants, whereas the application of MOFs to the detection of the pollutants with more complicated structures, such as endocrine disrupting chemicals (EDCs), has rarely been explored. The difficulties faced in the sensing of EDCs include their electronic stability and the structural similarity among homologues, which could be overcome by the incorporation of enzymatic reaction...
August 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28827713/diethylstilbestrol-administration-inhibits-theca-cell-androgen-and-granulosa-cell-estrogen-production-in-immature-rat-ovary
#20
Yoshitaka Imamichi, Toshio Sekiguchi, Takeshi Kitano, Takashi Kajitani, Reiko Okada, Yoshihiko Inaoka, Kaoru Miyamoto, Junsuke Uwada, Satoru Takahashi, Takahiro Nemoto, Asuka Mano, Md Rafiqul Islam Khan, Md Tariqul Islam, Koh-Ichi Yuhki, Hitoshi Kashiwagi, Fumitaka Ushikubi, Nobuo Suzuki, Takanobu Taniguchi, Takashi Yazawa
Diethylstilbestrol (DES), a strong estrogenic compound, is well-known to affect the reproductive system. In this study, we investigated the effects of DES administration on gonadotropin levels and ovarian steroidogenesis in prepubertal rats. DES treatment acutely reduced serum LH levels, followed by a reduction in the expression of various steroidogenesis-related genes in theca cells. Serum FSH levels were almost unaffected by DES-treatment, even though Cyp19a1 expression was markedly reduced. Serum progesterone, testosterone and estradiol levels were also declined at this time...
August 21, 2017: Scientific Reports
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