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Henri Rochefort
The selective increase in the incidence of hormone-dependent cancers (breast, prostate, testicular) in industrialized countries is associated with the increasing number of endocrine disruptors (EDs) in the environment and raises questions about the role of EDs in mammary carcinogenesis. Answering these questions is difficult because the number of EDs is large and varies with time. Moreover hormonal carcinogenesis is multifactorial and progresses slowly and in stages. This discussion will be limited to breast cancer and three EDs: distilbene, bisphenol A (BPA), and dichlorodiphenyltrichloroethane (DDT)...
September 2017: Comptes Rendus Biologies
Shubhashis Datta, Sudipta Panja, Prithiba Mitra, Mintu Halder
The photophysical properties of a new distilbene fluorophore, DPDB, belonging to the conjugated polyene family is found to be well modulated with the variation of the microenvironment. Compared to the ground state, the excited-state photophysical properties of the fluorophore have been altered to larger extents with the variation of polarity and the hydrogen-bonding nature of solvents. The change in the fluorescence intensity of DPDB shows a nice correlation with the aggregation behavior of different surfactants which have been utilized for the determination of the CMC of surfactants...
October 6, 2015: Langmuir: the ACS Journal of Surfaces and Colloids
Patrick Fénichel, Françoise Brucker-Davis, Nicolas Chevalier
The Distilbène® story is a dramatic episode which belongs to the history of medicine. It provided several useful lessons such as the importance of evidence-based medicine and the hazard to develop treatments during pregnancy without careful animal verifications. However, this experience has also provided unexpected progress by suggesting new pathophysiological concepts: fetal programming of adult diseases and/or transgenerational transmission of environmental effects through epigenetic modifications.
July 2015: Annales D'endocrinologie
A Balamurugan, Vikash Kumar, M Jayakannan
A triple-action π-conjugated polymer chemosensor is developed for sensing temperature, selective detection of copper(ii) metal-ion and biological species - amino acids, in two wavelength optical switches based on red-fluorescent and blue-fluorescent molecular probes.
January 25, 2014: Chemical Communications: Chem Comm
Lara R Gawenis, Emily M Bradford, Seth L Alper, Vikram Prasad, Gary E Shull
Anion secretion by colonic epithelium is dependent on apical CFTR-mediated anion conductance and basolateral ion transport. In many tissues, the NKCC1 Na(+)-K(+)-2Cl(-) cotransporter mediates basolateral Cl(-) uptake. However, additional evidence suggests that the AE2 Cl(-)/HCO(3)(-) exchanger, when coupled with the NHE1 Na(+)/H(+) exchanger or a Na(+)-HCO(3)(-) cotransporter (NBC), contributes to HCO(3)(-) and/or Cl(-) uptake. To analyze the secretory functions of AE2 in proximal colon, short-circuit current (I(sc)) responses to cAMP and inhibitors of basolateral anion transporters were measured in muscle-stripped wild-type (WT) and AE2-null (AE2(-/-)) proximal colon...
April 2010: American Journal of Physiology. Gastrointestinal and Liver Physiology
Lesya M Shuba, Sergey Missan, Pavel Zhabyeyev, Paul Linsdell, Terence F McDonald
The objective of this study on guinea-pig and rabbit ventricular myocytes was to evaluate the sensitivities of swelling-activated Cl- current (ICl(swell)) and cAMP-dependent cystic fibrosis transmembrane regulator (CFTR) Cl- current (ICl(CFTR)) to block by dideoxyforskolin and verapamil. The currents were recorded from whole-cell configured myocytes that were dialysed with a Cs+-rich pipette solution and superfused with either isosmotic Na+-, K+-, Ca2+-free solution that contained 140 mM sucrose or hyposmotic sucrose-free solution...
May 3, 2004: European Journal of Pharmacology
No abstract text is available yet for this article.
1950: Annales D'endocrinologie
L Bujan
An alteration of the male reproductive system as well as regional differences in this alterations were recently reported in several studies. That suggest a relationship between environmental conditions and spermatogenesis. Histories of dibromochloropropane distilbene and gossypol are indicative of the influence of occupational and drug exposure, or of the life style on the male reproductive tract. The present review deals with chemical (pesticides, metals ...), physical (ionising and non-ionising radiation's, endogenous heat) and life style factors (exogenous heat, posture, clothing, alcohol, tobacco, stress, sport, nutrition) susceptible to have a deleterious effect on spermatogenesis...
January 1998: Contraception, Fertilité, Sexualité
S Epelboin, S Bulwa
In the 1940's, diethylstilboestrol (DES) is one of the first hormonal therapeutics which was prescribed to many pregnant women by a lot of gynecologists. Until 1970, the indications of this therapy was enlarged, before carcinologic and reproductive consequences leaded to forbid obstetrical indications of DES (in France, in 1977 only). In France, 80,000 girls and 80,000 boys are suspected to have been exposed. As far as girls are concerned, the studies estimate between 23% and 36% the rate of infertility. These studies show also an increased incidence of ectopic pregnancy, spontaneous abortions, and premature delivery...
September 1993: Contraception, Fertilité, Sexualité
P Nesme, J Y Bayle, M Pérol, P Mathevet, D Vitrey, J C Guérin
The authors report the case of a patient aged 27 suffering from a clear cell adenocarcinoma of the vagina which was related to her mother taking Diethylstilboestrol or Distilbene (DES) during her pregnancy. This young woman presented with pulmonary metastases for which several trials of chemotherapy ended in failure. The case raises several problems amongst which are epidemiologies of cancers induced by Diethylstilboestrol (DES), their prognosis as well as the therapeutic strategies at the time of diagnosis and the recurrences which occur as metastases...
1993: Revue des Maladies Respiratoires
R Beauwens, J Crabbé, M Rentmeesters
1. Vanadate, considered by some as a candidate for physiological modulation of Na pumping activity, was studied in the isolated toad urinary bladder. It produced a decrease in Na transport activity that was reversible and could be partially antagonized by pretreatment with a disulphonic distilbene derivative, SITS. This suggests an intracytoplasmic site of action for vanadate. Other transition metal salts, prepared from Ta and Nb, produced instead a transient rise in Na transport and this was unaffected by SITS...
January 1981: Journal of Physiology
S C Yoon, M R Toon, A K Solomon
A new distilbene compound, 4',4'-dichloromercuric-2,2,2',2'-bistilbene tetrasulfonic acid (DCMBT), has been synthesized for use in studies of anion and water transport in the human red cell. DCMBT combines features of both the specific stilbene anion transport inhibitor, DIDS, and the mercurial water transport inhibitor, pCMBS. This new compound inhibits anion transport almost completely with a Ki of 15 microM. DCMBT also inhibits water transport by about 15-20% with a Ki of about 8 microM. Treatment of red cells with DIDS inhibits the effect of DCMBT on water transport, suggesting that anion transport and water transport are mediated by the same protein...
December 5, 1984: Biochimica et Biophysica Acta
E Drapier
A lot has been written about the abnormalities seen in children born to women treated with distilbene during pregnancy. The author reviews the current state of the certainties and the doubts. It seems that the increased number of miscarriages, extra-uterine pregnancies and perinatal deaths are probably due to the maternal treatment which is also responsible for semen abnormalities.
April 1984: Revue Française de Gynécologie et D'obstétrique
R L Vereecken, J Roelens, K de Jaegher, H Verduyn, Lauwerijns, J Derluyn
No abstract text is available yet for this article.
January 1972: Acta Urologica Belgica
M R Toon, A K Solomon
The new distilbene compound, DCMBT (4,4'-dichloromercuric-2,2,2',2'-bistilbene tetrasulfonic acid) synthesized by Yoon et al. (Biochim. Biophys. Acta 778 (1984) 385-389) was used to study the relation between urea transport and anion exchange in human red cells. DCMBT, which combines properties of both the specific stilbene anion exchange inhibitor, DIDS, and the water and urea transport inhibitor, pCMBS, had previously been shown to inhibit anion transport almost completely and water transport partially. We now report that DCMBT also inhibits urea transport almost completely and that covalent DIDS treatment reverses the inhibition...
December 19, 1985: Biochimica et Biophysica Acta
J C Pons, J Goujard, C Derbanne, M Tournaire
This study analyses the outcome of 110 pregnancies that occurred in 57 patients who were exposed to DES (DiEthylStilboestrol) during their fetal life. The quantities of Distilbene that were received in the first trimester of the pregnancy were the same in France and in the United States. The obstetrical complications of exposure in utero to DES were identically the same in France and in the United States. Of particular note is the high level of extra-uterine pregnancies (15%) and of 1st and 2nd trimester miscarriages (42%)...
1988: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
N H Bzowej, H B Niznik, P Seeman
In order to investigate the possibility that there may be two conformationally distinct dopamine D1 binding sites, the effect of lysine-modifying agents on striatal dopamine D1 receptors was investigated. Treatment with the distilbene derivative, 4,4'-diisothiocyanostilbene-2,2'-disulfonate, (DIDS), resulted in an irreversible D1 receptor inactivation that was associated with a 70% loss of binding sites. The remaining DIDS-insensitive sites displayed both a decreased affinity (approximately 5 fold) for the D1 antagonist SCH-23390 and an enhanced affinity of dopaminergic agonists (approximately 10 fold) for the agonist high-affinity form of the receptor...
April 29, 1988: Biochemical and Biophysical Research Communications
A Bahinski, A C Nairn, P Greengard, D C Gadsby
In heart cells, cyclic AMP-dependent protein kinase (PKA) regulates calcium- and potassium-ion current by phosphorylating the ion channels or closely associated regulatory proteins. We report here that isoprenaline induced large chloride-ion currents in voltage-clamped, internally-dialysed myocytes from guinea-pig ventricles. The Cl- current could be activated by intracellular dialysis with cAMP or the catalytic subunit of PKA, indicating regulation by phosphorylation. In approximately symmetrical solutions of high Cl- concentration, the macroscopic cardiac Cl- current showed little rectification, unlike the single-channel current in PKA-regulated Cl- channels of airway epithelial cells...
August 31, 1989: Nature
A Bergogne
No abstract text is available yet for this article.
May 1992: Revue de L'infirmière
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