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https://www.readbyqxmd.com/read/29235940/slc9b1-methylation-predicts-fetal-intolerance-of-labor
#1
Anna K Knight, Karen N Conneely, Varun Kilaru, Dawayland Cobb, Jennifer L Payne, Samantha Meilman, Elizabeth J Corwin, Zachary A Kaminsky, Anne L Dunlop, Alicia K Smith
Fetal intolerance of labor is a common indication for delivery by Caesarean section. Diagnosis is based on the presence of category III fetal heart rate tracing, which is an abnormal heart tracing associated with increased likelihood of fetal hypoxia and metabolic acidemia. This study analyzed data from 177 unique women who, during their prenatal visits (7-15 weeks and/or 24-32 weeks) to Atlanta area prenatal care clinics, consented to provide blood samples for DNA methylation (HumanMethylation450 BeadChip) and gene expression (Human HT-12 v4 Expression BeadChip) analyses...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29235933/faster-ticking-rate-of-the-epigenetic-clock-is-associated-with-faster-pubertal-development-in-girls
#2
Alexandra M Binder, Camila Corvalan, Verónica Mericq, Ana Pereira, José Luis Santos, Steve Horvath, John Shepherd, Karin B Michels
Epigenetic age is an indicator of biological aging, capturing the impact of environmental and behavioral influences across time on cellular function. Deviance between epigenetic age and chronological age (AgeAccel) is a predictor of health. Pubertal timing has similarly been associated with cancer risk and mortality rate among females. We examined the association between AgeAccel and pubertal timing and adolescent breast composition in the longitudinal Growth and Obesity Cohort Study. AgeAccel was estimated in whole blood using the Horvath method at breast Tanner 2 (B2) and 4 (B4)...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29235167/care-for-child-development-an-intervention-in-support-of-responsive-caregiving-and-early-child-development
#3
J E Lucas, L M Richter, B Daelmans
BACKGROUND: An estimated 43% of children younger than 5 years of age are at elevated risk of failing to achieve their human potential. In response, the World Health Organization and UNICEF developed Care for Child Development (CCD), based on the science of child development, to improve sensitive and responsive caregiving and promote the psychosocial development of young children. METHODS: In 2015, the World Health Organization and UNICEF identified sites where CCD has been implemented and sustained...
January 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29235099/variations-from-morning-to-afternoon-of-middle-cerebral-and-umbilical-artery-blood-flow-and-fetal-heart-rate-variability-and-fetal-characteristics-in-the-normally-developing-fetus
#4
Tehila Avitan, Ari Sanders, Ursula Brain, Dan Rurak, Tim F Oberlander, Ken Lim
OBJECTIVE: To determine if there are changes in maternal uterine blood flow, fetal brain blood flow, fetal heart rate variability, and umbilical blood flow between morning (AM) and afternoon (PM) in healthy, uncomplicated pregnancies. STUDY DESIGN: In this prospective study, 68 uncomplicated singleton pregnancies (mean 35 + 0.7 weeks gestation) underwent a standard observational protocol at both 08:00 (AM) and 13:30 (PM) of the same day. This protocol included Doppler measurements of uterine, umbilical, and fetal middle cerebral artery (MCA) volume flow parameters (flow, HR, peak systolic velocity [PSV], PI, and RI) followed by computerized cardiotocography...
December 13, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29234808/effect-of-levothyroxine-on-miscarriage-among-women-with-normal-thyroid-function-and-thyroid-autoimmunity-undergoing-in-vitro-fertilization-and-embryo-transfer-a-randomized-clinical-trial
#5
Haining Wang, Hongwei Gao, Hongbin Chi, Lin Zeng, Wenhua Xiao, Yanrong Wang, Rong Li, Ping Liu, Chen Wang, Qing Tian, Zehong Zhou, Jin Yang, Ye Liu, Rui Wei, Ben Willem J Mol, Tianpei Hong, Jie Qiao
Importance: Presence of thyroid autoantibodies in women with normal thyroid function is associated with increased risk of miscarriage. Whether levothyroxine treatment improves pregnancy outcomes among women undergoing in vitro fertilization and embryo transfer (IVF-ET) is unknown. Objective: To determine the effect of levothyroxine on miscarriage among women undergoing IVF-ET who had normal thyroid function and tested positive for thyroid autoantibodies. Design, Setting, and Participants: An open-label, randomized clinical trial involving 600 women who tested positive for the antithyroperoxidase antibody and were being treated for infertility at Peking University Third Hospital from September 2012 to March 2017...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29234522/maternal-mental-health-and-child-problem-behaviours-disentangling-the-role-of-depression-and-borderline-personality-dysfunction
#6
Fay Huntley, Nicola Wright, Andrew Pickles, Helen Sharp, Jonathan Hill
Background: It is not known whether associations between child problem behaviours and maternal depression can be accounted for by comorbid borderline personality disorder (BPD) dysfunction. Aim: To examine the contributions of maternal depression and BPD symptoms to child problem behaviours. Method: Depression trajectories over the first-year postpartum were generated using repeated measurement from a general population sample of 997 mothers recruited in pregnancy...
November 2017: BJPsych Open
https://www.readbyqxmd.com/read/29233668/expression-of-hmgb1-in-maternal-exposure-to-fine-particulate-air-pollution-induces-lung-injury-in-rat-offspring-assessed-with-micro-ct
#7
Wenting Tang, Suran Huang, Lili Du, Wen Sun, Zhiqiang Yu, Yanmei Zhou, Jingsi Chen, Xiuying Li, Xiaomei Li, Bolan Yu, Dunjin Chen
OBJECTIVES: Maternal particulate matter with less than 2.5 μm in diameter (PM2.5) is associated with an increased risk for acute lower respiratory infections and allergic airway inflammation; however, its effect on the developing lung remains unclear. The aim of this study is to determine the effect of maternal PM2.5 during pregnancy on lung development in offspring. METHODS: Timed pregnant Sprague-Dawley rats were treated with PM2.5 (0.1, 0.5, 2.5, or 7.5 mg/kg) once every 3 days from day 0-18 of pregnancy and delivered at term...
December 9, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29233116/reference-ranges-for-foetal-nasal-bone-length-prenasal-thickness-and-interocular-distance-at-18-to-24%C3%A2-weeks-gestation-in-low-risk-pregnancies
#8
Ayşegül Altunkeser, M Kazım Körez
BACKGROUND: The aim of the present study was to establish the normal ranges for foetal nasal bone length (NBL), prenasal skin thickness (PNT), interocular distance (IOD), and ratio of prenasal thickness to- nasal bone length (PNT/ NBL) at 18-24 weeks using two-dimensional (2D) ultrasound. METHODS: This study was a retrospective study of prenatal ultrasonographic records from 407 foetuses between 18 and 24 weeks gestational age (GA). The NBL, PNT, IOD, PNT/ NBL ratio, biparietal diameter (BPD), and femur length (FL) were investigated...
December 12, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29233055/universal-screening-program-in-pregnant-women-and-newborns-at-risk-for-sickle-cell-disease-first-report-from-northern-italy
#9
Mariachiara Lodi, Elena Bigi, Giovanni Palazzi, Lara Vecchi, Riccardo Morandi, Monica Setti, Silvana Borsari, Giuliano Bergonzini, Lorenzo Iughetti, Donatella Venturelli
The implementation of screening programs for early detection of patients with sickle cell disease has become necessary in Italy as a result of the high rate of migration from areas with a high prevalence of the disease (Sub-Saharan Africa, Middle East and the Balkans). Following a pilot study performed in the province of Modena, Italy in 2011-2013, an official screening program was established on May 31 2014 for all pregnant women, free-of-charge for the family according to the National Guidelines for Physiological Pregnancy...
December 12, 2017: Hemoglobin
https://www.readbyqxmd.com/read/29232625/prenatal-detection-of-trisomy-8-mosaicism-pregnancy-outcome-and-follow-up-of-a-series-of-17-consecutive-cases
#10
Matteo Cassina, Annapaola Calò, Leonardo Salviati, Alberta Alghisi, Annamaria Montaldi, Maurizio Clementi
OBJECTIVE: To study the outcome of a series of individuals with prenatal detection of trisomy 8 mosaicism by chorionic villus sampling (CVS) and/or amniocentesis. STUDY DESIGN: The databases of two Italian genetics units were reviewed to identify all consultations requested during pregnancy because of trisomy 8 mosaicism. To evaluate the pregnancy outcome, the regional registry of congenital malformations (including terminations of pregnancies) was consulted; additional follow-up data were collected by a telephone interview...
December 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29232272/relative-effects-of-age-race-and-stage-on-mortality-in-gestational-choriocarcinoma
#11
Christopher M Tarney, Chunqiao Tian, Eric R Craig, Barbara A Crothers, John K Chan, Glenn D Gist, Nicholas W Bateman, Thomas P Conrads, Chad A Hamilton, George Larry Maxwell, Kathleen M Darcy
OBJECTIVE: Gestational choriocarcinoma is a malignant form of gestational trophoblastic disease that usually arises after a molar pregnancy, but may follow any antecedent pregnancy. Investigations in this rare cancer are limited. We evaluated the prognostic effects of age, race, and stage in choriocarcinomas diagnosed for 4 decades. METHODS: Patients diagnosed as having gestational choriocarcinoma between 1973 and 2014 from the Surveillance, Epidemiology, and End Results program were eligible...
December 11, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29229609/recent-advances-in-pre-exposure-prophylaxis-for-hiv
#12
REVIEW
Monica Desai, Nigel Field, Robert Grant, Sheena McCormack
Although pre-exposure prophylaxis (PrEP)-the use of antiretroviral drugs by non-infected people to prevent the acquisition of HIV-is a promising preventive option, important public health questions remain. Daily oral emtricitabine (FTC)-tenofovir disoproxil fumarate (TDF) is highly efficacious in preventing the acquisition of HIV in people at risk as a result of a range of different types of sexual exposure. There is good evidence of efficacy in women and men, and when men who have sex with men use event based dosing...
December 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29229486/screening-for-spontaneous-preterm-birth-and-resultant-therapies-to-reduce-neonatal-morbidity-and-mortality-a-review
#13
REVIEW
Angelica V Glover, Tracy A Manuck
Despite considerable effort aimed at decreasing the incidence of spontaneous preterm birth, it remains the leading cause of perinatal morbidity and mortality. Screening strategies are imperfect. Approaches used to identify women considered by historical factors to be low risk for preterm delivery (generally considered to be women with singleton pregnancies without a history of a previous preterm birth) as well as those at high risk for preterm birth (those with a previous preterm birth, short cervix, or multiple gestation) continue to evolve...
December 9, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29229409/postpartum-depression-screening-and-pelvic-floor-symptoms-among-women-referred-to-a-specialty-postpartum-perineal-clinic
#14
Carolyn W Swenson, Julia A DePorre, Jessica K Haefner, Mitchell B Berger, Dee E Fenner
BACKGROUND: Postpartum depression (PPD) and pelvic floor disorders are both common conditions that affect women; however, the association between the two has yet to be determined. OBJECTIVE: The aims of our study are to: 1) determine the prevalence of a positive postpartum depression screen (PPD) in a specialty postpartum perineal clinic, and 2) identify risk factors for postpartum depression in this population. STUDY DESIGN: A retrospective chart review was performed of 294 women referred to a specialty postpartum perineal clinic at the University of Michigan between March 30, 2012 and May 3, 2016...
December 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29229321/the-role-of-aspirin-heparin-and-other-interventions-in-the-prevention-and-treatment-of-fetal-growth-restriction
#15
REVIEW
Katie M Groom, Anna L David
Fetal growth restriction and related placental pathologies such as preeclampsia, stillbirth, and placental abruption are believed to arise in early pregnancy when inadequate remodeling of the maternal spiral arteries leads to persistent high-resistance and low-flow uteroplacental circulation. The consequent placental ischaemia, reperfusion injury, and oxidative stress are associated with an imbalance in angiogenic/antiangiogenic factors. Many interventions have centered on the prevention and/or treatment of preeclampsia with results pertaining to fetal growth restriction and small-for-gestational-age pregnancy often included as secondary outcomes because of the common pathophysiology...
December 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29229282/what-is-the-optimal-duration-of-human-chorionic-gonadotrophin-surveillance-following-evacuation-of-a-molar-pregnancy-a-retrospective-analysis-on-over-20-000-consecutive-patients
#16
Christopher Coyle, Dee Short, Lauren Jackson, Neil J Sebire, Baljeet Kaur, Richard Harvey, Philip M Savage, Michael J Seckl
OBJECTIVE: To quantify the risk of developing post-molar gestational trophoblastic neoplasia (pGTN) beyond the first normal human chorionic gonadotrophin (hCG) in women who have had a complete (CHM) or partial molar pregnancy (PHM) and to re-evaluate the current UK Hydatidiform mole hCG surveillance guidelines. METHODS: The Charing Cross Hospital Trophoblast Disease Centre database was screened to identify all registered cases of hydatidiform mole (HM) between 1980 and 2009...
December 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29228827/conservative-versus-active-management-in-hellp-syndrome-results-from-a-cohort-study
#17
Marie Cavaignac-Vitalis, Fabien Vidal, M D Caroline Simon-Toulza, Pierre Boulot, Paul Guerby, Elodie Chantalat, Parant M D Olivier
OBJECTIVE: HELLP syndrome exposes to severe maternal and fetal complications. Prompt delivery is thus recommended after 34 weeks of gestation, or earlier in case of nonreassuring maternofetal conditions. However, no consensus has been raised in the treatment of HELLP syndrome occurring before 34 weeks of gestation, when both maternal and fetal conditions are stable: it remains still unclear whether an active attitude should be prioritized over expectant management. Herein we aimed to compare mother and child outcomes according to the type of obstetrical management, either active or conservative...
December 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29227846/maternal-human-chorionic-gonadotrophin-concentrations-in-very-early-pregnancy-and-risk-of-hyperemesis-gravidarum-a-retrospective-cohort-study-of-4372-pregnancies-after-in-vitro-fertilization
#18
Johanne Dypvik, Andrea Lid Pereira, Tom Gunnar Tanbo, Anne Eskild
OBJECTIVE: We investigated the association of human chorionic gonadotrophin (hCG) concentrations on a fixed day in very early pregnancy with development of hyperemesis gravidarum. STUDY DESIGN: This retrospective cohort study included 3107 singleton and 1265 twin pregnancies after in vitro fertilization treated at Department of Reproductive Medicine, Rikshospitalet, Oslo University Hospital, Norway in the period 1996-2013. Maternal serum hCG concentrations was measured on day 12 after embryo transfer...
December 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29227010/pre-labour-screening-for-intrapartum-fetal-compromise-in-low-risk-pregnancies-at-term-cerebroplacental-ratio-and-placental-growth-factor
#19
Larissa N Bligh, Amal A Alsolai, Ristan M Greer, Sailesh Kumar
OBJECTIVES: We sought to determine the screening performance of a low fetal cerebroplacental ratio (a marker of fetal adaptation to suboptimal growth) and maternal placental growth factor levels, respectively, both in isolation and in combination, for the detection of cesarean section for intrapartum fetal compromise and serious composite neonatal outcome. METHODS: A prospective cohort study was performed on low risk women with uncomplicated singleton pregnancies from 36 weeks to delivery...
December 11, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29226278/effects-of-multiple-freeze-thaw-cycles-on-measurements-of-potential-novel-biomarkers-associated-with-adverse-pregnancy-outcomes
#20
Sandra L Rebholz, John T Melchior, Jeffrey A Welge, Alan T Remaley, W Sean Davidson, Laura A Woollett
World-wide, millions of women enter preterm labor or have small newborns. Effective biomarkers are needed to identify women at risk for these adverse outcomes. A time and cost effective way to examine any potentially new biomarkers in samples collected during prior studies or trials that had been assayed for other metabolites would be highly useful. Thus, the current study aimed to determine if samples that had been previously thawed and re-frozen could be re-assayed for novel biomarkers, those being lipoprotein composition (sizing, proteome, lipids) and combined cholesterol and cytokine concentrations...
2017: Journal of Clinical and Laboratory Medicine
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