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https://www.readbyqxmd.com/read/29146412/skeletal-muscle-overexpression-of-nicotinamide-phosphoribosyl-transferase-in-mice-coupled-with-voluntary-exercise-augments-exercise-endurance
#1
Sheila R Costford, Bram Brouwers, Meghan E Hopf, Lauren M Sparks, Mauro Dispagna, Ana P Gomes, Heather H Cornnell, Chris Petucci, Peter Phelan, Hui Xie, Fanchao Yi, Glenn A Walter, Timothy F Osborne, David A Sinclair, Randall L Mynatt, Julio E Ayala, Stephen J Gardell, Steven R Smith
OBJECTIVE: Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD(+)), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle (NamptTg) and hypothesized that NamptTg mice would have increased oxidative capacity, endurance performance, and mitochondrial gene expression, and would be rescued from metabolic abnormalities that developed with high fat diet (HFD) feeding...
November 6, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29141022/trabecular-bone-in-the-calcaneus-of-runners
#2
Andrew Best, Brigitte Holt, Karen Troy, Joseph Hamill
Trabecular bone of the human calcaneus is subjected to extreme repetitive forces during endurance running and should adapt in response to this strain. To assess possible bone functional adaptation in the posterior region of the calcaneus, we recruited forefoot-striking runners (n = 6), rearfoot-striking runners (n = 6), and non-runners (n = 6), all males aged 20-41 for this institutionally approved study. Foot strike pattern was confirmed for each runner using a motion capture system. We obtained high resolution peripheral computed tomography scans of the posterior calcaneus for both runners and non-runners...
2017: PloS One
https://www.readbyqxmd.com/read/29139646/physical-fitness-and-digit-ratio-2d-4d-in-male-students-from-wroc%C3%A5-aw-poland
#3
Slawomir Koziel, Marek Kociuba Mail, Raja Chakraborty, Zofia Ignasiak
There is sex-difference in humans as regards aerobic efficiency, physical strength and endurance and the sex difference is greatly dependent upon differential concentration of testosterone during different phases of growth and development including the intrauterine phase or prenatal growth. Second-to-fourth digit lengths ratio (2D:4D) is an putative indicator of prenatal testosterone exposure. Lower 2D:4D indicates higher prenatal testosterone exposure and vice versa. Males generally have lower 2D:4D than females...
March 2017: Collegium Antropologicum
https://www.readbyqxmd.com/read/29136482/impact-of-an-elementary-school-based-intervention-on-physical-activity-time-and-aerobic-capacity-georgia-2013-2014
#4
Hayley A Braun, Christi M Kay, Patricia Cheung, Paul S Weiss, Julie A Gazmararian
OBJECTIVES: The objectives of this study were to (1) determine the impact of a 1-year elementary school physical activity intervention on changes in teacher-reported school-based physical activity time and (2) assess the relationship between these changes and changes in student aerobic capacity. METHODS: HealthMPowers, a nonprofit organization, provided a multicomponent physical activity intervention to 3479 students in 39 schools in Georgia during 2013-2014. HealthMPowers administered a survey to faculty members before (August 2013) and after (May 2014) the intervention to measure student physical activity times...
November 2017: Public Health Reports
https://www.readbyqxmd.com/read/29134050/mental-strategies-predict-performance-and-satisfaction-with-performance-among-soccer-players
#5
Magdalena Kruk, Jan Blecharz, Monika Boberska, Karolina Zarychta, Aleksandra Luszczynska
This study investigated the changes in mental strategies across the season and their effects on performance and satisfaction with individual performance. Data were collected three times: at the pre-season at Time 1 (T1; baseline), in the mid-season at Time 2 (T2; two-month follow-up), and at the end-of-season at Time 3 (T3; nine-month follow-up) among male soccer players (N = 97) aged 16-27. Athletes completed the questionnaires assessing the use of nine psychological strategies in competition and the level of satisfaction with individual performance...
October 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29133160/the-changes-of-red-blood-cell-viscoelasticity-and-sports-anemia-in-male-24-hr-ultra-marathoners
#6
Che-Hung Liu, Yen-Fang Tseng, Jiun-I Lai, Yin-Quan Chen, Shih-Hao Wang, Wei-Fong Kao, Li-Hua Li, Yu-Hui Chiu, Chorng-Kuang How, Wen-Han Chang
BACKGROUND: In endurance sports, stress, dehydration and release of chemical factors have been associated with red blood cell (RBC) alterations of structure and function, which may contribute to sports anemia, a well-observed phenomenon during long-distance running. Until now, the investigation of the changes of viscoelastic properties of RBC membrane, a decisive factor of RBC deformability to avoid hemolysis, is lacking, especially in an Oriental population. METHODS: nineteen runners were prospectively recruited into our study...
November 10, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29129021/the-effect-of-natural-or-simulated-altitude-training-on-high-intensity-intermittent-running-performance-in-team-sport-athletes-a-meta-analysis
#7
REVIEW
Michael J Hamlin, Catherine A Lizamore, Will G Hopkins
BACKGROUND: While adaptation to hypoxia at natural or simulated altitude has long been used with endurance athletes, it has only recently gained popularity for team-sport athletes. OBJECTIVE: To analyse the effect of hypoxic interventions on high-intensity intermittent running performance in team-sport athletes. METHODS: A systematic literature search of five journal databases was performed. Percent change in performance (distance covered) in the Yo-Yo intermittent recovery test (level 1 and level 2 were used without differentiation) in hypoxic (natural or simulated altitude) and control (sea level or normoxic placebo) groups was meta-analyzed with a mixed model...
November 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29125913/standardized-kaempferia-parviflora-extract-enhances-exercise-performance-through-activation-of-mitochondrial-biogenesis
#8
Mi-Bo Kim, Taeyoon Kim, Changhee Kim, Jae-Kwan Hwang
Exercise enhances mitochondrial biogenesis in skeletal muscle. Increased mitochondrial function and content can contribute to the improvement in skeletal muscle function and the benefits of exercise by increasing the response to energy demands. The effect of standardized Kaempferia parviflora extract (KPE) on exercise performance was accessed in L6 myotubes and C57BL/6J mice. KPE significantly activated peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and increased mitochondrial density in L6 myotubes...
November 10, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29120983/assessing-differences-in-anthropometric-and-fitness-characteristics-between-police-academy-cadets-and-incumbent-officers
#9
Robin Orr, J Jay Dawes, Rodney Pope, Joseph Terry
The physical fitness of police officers must be developed in new cadets and sustained in incumbent officers. The aims of this study were to profile and compare the anthropometric and fitness characteristics of police academy cadets and incumbent officers of varying ages from a single police force. Retrospective data for 84 police academy cadets (♂=66, mean age=27.96±5.73 yrs; ♀=18, mean age=30.50±5.76 yrs) and 80 incumbent police officers (♂=73, mean age=39.43±8.28 yrs; ♀=7, mean age=37.86±3.67 yrs) were compiled...
November 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29120091/running-wheel-activity-delays-mitochondrial-respiratory-flux-decline-in-aging-mouse-muscle-via-a-post-transcriptional-mechanism
#10
Sarah Stolle, Jolita Ciapaite, Aaffien C Reijne, Alzbeta Talarovicova, Justina C Wolters, Raúl Aguirre-Gamboa, Pieter van der Vlies, Kim de Lange, Pieter B Neerincx, Gerben van der Vries, Patrick Deelen, Morris A Swertz, Yang Li, Rainer Bischoff, Hjalmar P Permentier, Peter L Horvatovitch, Albert K Groen, Gertjan van Dijk, Dirk-Jan Reijngoud, Barbara M Bakker
Loss of mitochondrial respiratory flux is a hallmark of skeletal muscle aging, contributing to a progressive decline of muscle strength. Endurance exercise alleviates the decrease in respiratory flux, both in humans and in rodents. Here, we dissect the underlying mechanism of mitochondrial flux decline by integrated analysis of the molecular network. Mice were given a lifelong ad libitum low-fat or high-fat sucrose diet and were further divided into sedentary and running-wheel groups. At 6, 12, 18 and 24 months, muscle weight, triglyceride content and mitochondrial respiratory flux were analysed...
November 9, 2017: Aging Cell
https://www.readbyqxmd.com/read/29119246/skeletal-muscle-and-performance-adaptations-to-high-intensity-training-in-elite-male-soccer-players-speed-endurance-runs-versus-small-sided-game-training
#11
Dan Fransson, Tobias Schmidt Nielsen, Karl Olsson, Tobias Christensson, Paul S Bradley, Ioannis G Fatouros, Peter Krustrup, Nikolai Baastrup Nordsborg, Magni Mohr
PURPOSE: To examine the skeletal muscle and performance responses across two different exercise training modalities which are highly applied in soccer training. METHODS: Using an RCT design, 39 well-trained male soccer players were randomized into either a speed endurance training (SET; n = 21) or a small-sided game group (SSG; n = 18). Over 4 weeks, thrice weekly, SET performed 6-10 × 30-s all-out runs with 3-min recovery, while SSG completed 2 × 7-9-min small-sided games with 2-min recovery...
November 8, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29118957/morphological-peculiarities-of-neuromuscular-junctions-among-different-fiber-types-effect-of-exercise
#12
Teet Seene, Maria Umnova, Priit Kaasik
The aim of our research was to examine whether there are differences in the morphology of neuromuscular junctions of different types of muscle fibers in rodents, and after their adaptation to six weeks endurance exercise training. After 5-day acclimation, Wistar rats were subjected to run with the speed 35 m/min during 6 week, 5 days per week and the training volume reached 60 min per day. Muscle samples for ultrastructural studies were fixed, dehydrated and embedded in Epon-812. Ultra-thin sections were cut from longitudinally and transversely oriented blocs, using 4 blocks from each animal...
June 27, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29117428/change-in-knee-flexor-torque-after-fatiguing-exercise-identifies-previous-hamstring-injury-in-football-players
#13
Cameron Lord, Fadi Ma'ayah, Anthony J Blazevich
PURPOSE: Muscular fatigue and inter-limb strength asymmetry are factors known to influence hamstring injury risk, however limb-specific exacerbation of knee flexor (hamstrings) torque production after fatiguing exercise has previously been ignored. To investigate changes in muscular force production before and after sport-specific (repeated-sprint) and non-specific (knee extension-flexion) fatiguing exercise, and explore the sensitivity and specificity of isokinetic endurance (i.e. muscle-specific) and single-leg vertical jump (i...
November 8, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29112626/effects-of-ad-libitum-low-carbohydrate-high-fat-dieting-in-middle-age-male-runners
#14
Alexander J Heatherly, Lauren G Killen, Ashton F Smith, Hunter S Waldman, Angela Hollingsworth, Christie L Seltmann, Eric K O'Neal
PURPOSE: This study examined the effects of a 3-week ad libitum high fat (~70% of calories), low carbohydrate (<50 g/day) diet (LCHF) on markers of endurance performance in middle-aged, recreationally competitive male runners. METHODS: All subjects (n = 8) following their normal HC diet had anthropometric measures assessed and completed 5, 10-min running bouts at multiple individual race paces in the heat while physiological, metabolic variables and perceptual responses were recorded...
November 6, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29112054/lower-extremity-stiffness-considerations-for-testing-performance-enhancement-and-injury-risk
#15
Jon Brazier, Sean Maloney, Chris Bishop, Paul J Read, Anthony N Turner
Brazier, J, Maloney, S, Bishop, C, Read, PJ, and Turner, AN. Lower extremity stiffness: considerations for testing, performance enhancement, and injury risk. J Strength Cond Res XX(X): 000-000, 2017-Force-deformation characteristics of the lower limb have been associated with athletic performance and may modulate the risk of injury. Despite these known associations, measurements of lower extremity stiffness are not commonly administered by strength and conditioning coaches. This review provides an overview of the available literature pertaining to the effects of lower extremity stiffness on physical performance and injury risk...
November 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29107291/absence-of-the-kinase-s6k1-mimics-the-effect-of-chronic-endurance-exercise-on-glucose-tolerance-and-muscle-oxidative-stress
#16
C Binsch, T Jelenik, A Pfitzer, M Dille, S Müller-Lühlhoff, S Hartwig, S Karpinski, S Lehr, D G Kabra, A Chadt, M Roden, H Al-Hasani, T R Castañeda
OBJECTIVE: Ribosomal protein S6 Kinase-1 (S6K1) has been linked to resistance exercise-mediated improvements in glycemia. We hypothesized that S6K1 may also play a role in regulating glycemic control in response to endurance exercise training. METHODS: S6k1-knockout (S6K1KO) and WT mice on a 60 cal% high-fat diet were trained for 4 weeks on treadmills, metabolically phenotyped, and compared to sedentary controls. RESULTS: WT mice showed improved glucose tolerance after training...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29100826/sex-and-age-differences-in-physical-performance-a-comparison-of-army-basic-training-and-operational-populations
#17
Esther O Dada, Morgan K Anderson, Tyson Grier, Joseph A Alemany, Bruce H Jones
OBJECTIVES: To determine the age- and sex-specific differences of physical fitness performances and Body Mass Index (BMI) in basic training and the operational Army. DESIGN: Cross-sectional Study. METHODS: This secondary analysis utilizes retrospective surveys of U.S. Army Soldiers in Basic Combat Training (BCT) and operational units to compare physical performances between men and women as measured by the Army Physical Readiness Test (APFT)...
October 18, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29095264/effects-of-age-and-sex-on-epigenetic-modification-induced-by-an-acute-physical-exercise
#18
Marinella Coco, Vincenzo Perciavalle, Paolo Cavallari, Francesco Bolzoni, Adriana Carol Eleonora Graziano, Valentina Perciavalle
It has been observed that, after 2 hours of aerobic exercise, plasma interleukin-6 (IL-6) increases whereas nuclear concentrations of enzyme DNA methyltransferase (DNMT) 3B significantly decreased in peripheral blood mononuclear cells (PBMCs), with no change observed in DNMT3A. The aim of the present study was to detect differences in these changes induced by exercise in plasma IL-6 levels as well as in PBMC nuclear concentrations of DNMT3A and DNMT3B, in relation to age and sex. Four groups were studied: 12 young men (24...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29094622/long-term-effects-of-internet-supported-cognitive-behaviour-therapy
#19
Gerhard Andersson, Alexander Rozental, Roz Shafran, Per Carlbring
Internet-supported and therapist-guided cognitive behaviour therapy (ICBT) is effective for a range of problems in the short run, but less is known about the long-term effects with follow-ups of two years or longer. Areas covered: This paper reviews studies in which the long-term effects of guided ICBT were investigated. Following literature searches in PubMed and other sources meta-analytic statistics were calculated for 14 studies involving a total of 902 participants, and an average follow-up period of three years...
November 2, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29094382/low-intensity-vibration-increases-cartilage-thickness-in-obese-mice
#20
Tee Pamon, Vincent Bhandal, Benjamin J Adler, M Ete Chan, Clinton T Rubin
Obesity is associated with an elevated risk of osteoarthritis (OA). We examined here whether high fat diet administered in young mice, compromised the attainment of articular cartilage thickness. Further, we sought to determine if low intensity vibration (LIV) could protect the retention of articular cartilage in a mouse model of diet induced obesity. Five-week-old, male, C57BL/6 mice were separated into 3 groups (n = 10): Regular diet (RD), High fat diet (HF), and HF + LIV (HFv; 90Hz, 0.2g, 30 min/d, 5 d/w) administered for 6 weeks...
November 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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