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Predictive, personalized, preventive, participatory

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https://www.readbyqxmd.com/read/28575140/optimizing-drug-development-in-oncology-by-clinical-trial-simulation-why-and-how
#1
Jocelyn Gal, Gérard Milano, Jean-Marc Ferrero, Esma Saâda-Bouzid, Julien Viotti, Sylvie Chabaud, Paul Gougis, Christophe Le Tourneau, Renaud Schiappa, Agnes Paquet, Emmanuel Chamorey
In therapeutic research, the safety and efficacy of pharmaceutical products are necessarily tested on humans via clinical trials after an extensive and expensive preclinical development period. Methodologies such as computer modeling and clinical trial simulation (CTS) might represent a valuable option to reduce animal and human assays. The relevance of these methods is well recognized in pharmacokinetics and pharmacodynamics from the preclinical phase to postmarketing. However, they are barely used and are poorly regarded for drug approval, despite Food and Drug Administration and European Medicines Agency recommendations...
May 29, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28523298/role-of-genetic-polymorphism-in-nutritional-supplementation-therapy-in-personalized-medicine
#2
Nicolae Ovidiu Peneş, Bernard Weber, Silviu Dumitru Păun
Genetic-guided nutritional supplementation therapy in personalized medicine is the type of treatment that prevents and acts against errors during the copying process of a cell's deoxyribonucleic acid (DNA), mistakes that lead to diversification in the DNA sequence at certain locations, called single nucleotide polymorphisms (SNPs). Positive results are quickly achieved using one of the four types of therapy. These types are: personalized, when individual human genetic variations drive individual treatment, preventive, with a tailored healthcare strategy and therapeutic preventive drugs and vaccines, participatory, when empowered patients make informed choices and take responsibility of their own health and predictive, using a proactive approach to health and medicine...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28443607/novel-approaches-for-the-promotion-of-physical-activity-and-exercise-for-prevention-and-management-of-type-2-diabetes
#3
REVIEW
R Arena, M Sagner, N M Byrne, A D Williams, A McNeil, S J Street, A P Hills
Despite increased evidence for the importance of lifestyle modification, physical activity and diet in diabetes prevention and management, habitual physical activity levels have declined in recent decades in China and India. Further, other risk factors for type 2 diabetes, including overweight, obesity and physical inactivity, have also worsened. Here we present evidence for the importance of physical activity and exercise in the amelioration of type 2 diabetes and propose a novel approach to address the challenge of improving lifestyle behaviors in China and India-Movement is Medicine and a P4 (predictive, preventive, personalized and participatory) approach...
April 26, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28430854/dynamic-modeling-and-network-approaches-for-omics-time-course-data-overview-of-computational-approaches-and-applications
#4
Yulan Liang, Arpad Kelemen
Inferring networks and dynamics of genes, proteins, cells and other biological entities from high-throughput biological omics data is a central and challenging issue in computational and systems biology. This is essential for understanding the complexity of human health, disease susceptibility and pathogenesis for Predictive, Preventive, Personalized and Participatory (P4) system and precision medicine. The delineation of the possible interactions of all genes/proteins in a genome/proteome is a task for which conventional experimental techniques are ill suited...
April 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28391973/the-current-status-and-problems-confronted-in-delivering-precision-medicine-in-japan-and-europe
#5
REVIEW
Hideaki Bando
Precision medicine has been defined as "a predictive, preventive, personalized, and participatory health care service delivery model." Today, developments in next-generation sequencing and information technology have made precision medicine possible, with massive amounts of genetic, "omics," clinical, environmental, and lifestyle data now available. Unfortunately, differences in governmental support and health care regulations have resulted in heterogeneous progress among countries. In Japan, for example, precision cancer screening and treatments are increasingly being promoted, with collaboration among research, governmental, and pharmaceutical agencies taking place in the nationwide SCRUM-Japan cancer genome screening project...
February 22, 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/28356752/value-as-the-key-concept-in-the-health-care-system-how-it-has-influenced-medical-practice-and-clinical-decision-making-processes
#6
Chiara Marzorati, Gabriella Pravettoni
In the last 10 years, value has played a key role in the health care system. In this concept, innovations in medical practice and the increasing importance of patient centeredness have contributed to draw the attention of the medical community. Nonetheless, a large consensus on the meaning of "value" is still lacking: patients, physicians, policy makers, and other health care professionals have different ideas on which component of value may play a prominent role. Yet, shared clinical decision-making and patient empowerment have been recognized as fundamental features of the concept of value...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28270929/changing-paradigms-in-the-management-of-rejection-in-kidney-transplantation-evolving-from-protocol-based-care-to-the-era-of-p4-medicine
#7
Mirela Maier, Tomoko Takano, Ruth Sapir-Pichhadze
PURPOSE OF REVIEW: P4 medicine denotes an evolving field of medicine encompassing predictive, preventive, personalized, and participatory medicine. Using the example of kidney allograft rejection because of donor-recipient incompatibility in human leukocyte antigens, this review outlines P4 medicine's relevance to the various stages of the kidney transplant cycle. SOURCES OF INFORMATION: A search for English articles was conducted in Medline via OvidSP (up to August 18, 2016) using a combination of subject headings (MeSH) and free text in titles, abstracts, and author keywords for the concepts kidney transplantation and P4 medicine...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28183433/mechanisms-of-the-development-of-allergy-medall-introducing-novel-concepts-in-allergy-phenotypes
#8
REVIEW
Josep M Anto, Jean Bousquet, Mubeccel Akdis, Charles Auffray, Thomas Keil, Isabelle Momas, Dirkje S Postma, Rudolf Valenta, Magnus Wickman, Anne Cambon-Thomsen, Tari Haahtela, Bart N Lambrecht, Karin C Lodrup Carlsen, Gerard H Koppelman, Jordi Sunyer, Torsten Zuberbier, Isabelle Annesi-Maesano, Albert Arno, Carsten Bindslev-Jensen, Giuseppe De Carlo, Francesco Forastiere, Joachim Heinrich, Marek L Kowalski, Dieter Maier, Erik Melén, Henriette A Smit, Marie Standl, John Wright, Anna Asarnoj, Marta Benet, Natalia Ballardini, Judith Garcia-Aymerich, Ulrike Gehring, Stefano Guerra, Cynthia Hohmann, Inger Kull, Christian Lupinek, Mariona Pinart, Ingebjorg Skrindo, Marit Westman, Delphine Smagghe, Cezmi Akdis, Niklas Andersson, Claus Bachert, Stephane Ballereau, Ferran Ballester, Xavier Basagana, Anna Bedbrook, Anna Bergstrom, Andrea von Berg, Bert Brunekreef, Emilie Burte, Kai-Hakon Carlsen, Leda Chatzi, Jonathan M Coquet, Mirela Curin, Pascal Demoly, Esben Eller, Maria Pia Fantini, Leena von Hertzen, Vergard Hovland, Benedicte Jacquemin, Jocelyne Just, Theresa Keller, Renata Kiss, Manolis Kogevinas, Sibylle Koletzko, Susanne Lau, Irina Lehmann, Nicolas Lemonnier, Mika Mäkelä, Jordi Mestres, Peter Mowinckel, Rachel Nadif, Martijn C Nawijn, Johan Pellet, Isabelle Pin, Daniela Porta, Fanny Rancière, Emmanuelle Rial-Sebbag, Yvan Saeys, Martijn J Schuijs, Valerie Siroux, Christina G Tischer, Mathies Torrent, Raphaelle Varraso, Kalus Wenzel, Cheng-Jian Xu
Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non-IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years...
February 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27873024/p4%C3%A2-medicine-and-osteoporosis-a%C3%A2-systematic-review
#9
REVIEW
Klemen Kodrič, Klemen Čamernik, Darko Černe, Radko Komadina, Janja Marc
BACKGROUND: Osteoporosis is the most frequent bone metabolic disease. In order to improve early detection, prediction, prevention, diagnosis, and treatment of the disease, a new model of P4 medicine (personalized, predictive, preventive, and participatory medicine) could be applied. The aim of this work was to systematically review the publications of four different types of "omics" studies related to osteoporosis, in order to discover novel predictive, preventive, diagnostic, and therapeutic targets for better management of the geriatric population...
December 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27776531/integrating-precision-cancer-medicine-into-healthcare-policy-practice-and-research-challenges
#10
Gabrielle Bertier, Jian Carrot-Zhang, Vassilis Ragoussis, Yann Joly
Precision medicine (PM) can be defined as a predictive, preventive, personalized, and participatory healthcare service delivery model. Recent developments in molecular biology and information technology make PM a reality today through the use of massive amounts of genetic, 'omics', clinical, environmental, and lifestyle data. With cancer being one of the most prominent public health threats in developed countries, both the research community and governments have been investing significant time, money, and efforts in precision cancer medicine (PCM)...
October 24, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27747816/a-tamper-proof-audit-and-control-system-for-the-doctor-in-the-loop
#11
Peter Kieseberg, Bernd Malle, Peter Frühwirt, Edgar Weippl, Andreas Holzinger
The "doctor in the loop" is a new paradigm in information-driven medicine, picturing the doctor as authority inside a loop supplying an expert system with information on actual patients, treatment results, and possible additional (side-)effects, including general information in order to enhance data-driven medical science, as well as giving back treatment advice to the doctor himself. While this approach can be very beneficial for new medical approaches like P4 medicine (personal, predictive, preventive, and participatory), it also relies heavily on the authenticity of the data and thus increases the need for secure and reliable databases...
December 2016: Brain Informatics
https://www.readbyqxmd.com/read/27649826/from-personalized-to-precision-medicine-the-ethical-and-social-implications-of-rhetorical-reform-in-genomic-medicine
#12
Eric Juengst, Michelle L McGowan, Jennifer R Fishman, Richard A Settersten
Since the late 1980s, the human genetics and genomics research community has been promising to usher in a "new paradigm for health care"-one that uses molecular profiling to identify human genetic variants implicated in multifactorial health risks. After the completion of the Human Genome Project in 2003, a wide range of stakeholders became committed to this "paradigm shift," creating a confluence of investment, advocacy, and enthusiasm that bears all the marks of a "scientific/intellectual social movement" within biomedicine...
September 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27638683/personalized-medicine-evidence-of-normativity-in-its-quantitative-definition-of-health
#13
Henrik Vogt, Bjørn Hofmann, Linn Getz
Systems medicine, which is based on computational modelling of biological systems, is emerging as an increasingly prominent part of the personalized medicine movement. It is often promoted as 'P4 medicine' (predictive, preventive, personalized, and participatory). In this article, we test promises made by some of its proponents that systems medicine will be able to develop a scientific, quantitative metric for wellness that will eliminate the purported vagueness, ambiguity, and incompleteness-that is, normativity-of previous health definitions...
October 2016: Theoretical Medicine and Bioethics
https://www.readbyqxmd.com/read/27546358/the-p4-health-spectrum-a-predictive-preventive-personalized-and-participatory-continuum-for-promoting-healthspan
#14
REVIEW
Michael Sagner, Amy McNeil, Pekka Puska, Charles Auffray, Nathan D Price, Leroy Hood, Carl J Lavie, Ze-Guang Han, Zhu Chen, Samir Kumar Brahmachari, Bruce S McEwen, Marcelo B Soares, Rudi Balling, Elissa Epel, Ross Arena
Chronic diseases (i.e., noncommunicable diseases), mainly cardiovascular disease, cancer, respiratory diseases and type-2-diabetes, are now the leading cause of death, disability and diminished quality of life on the planet. Moreover, these diseases are also a major financial burden worldwide, significantly impacting the economy of many countries. Healthcare systems and medicine have progressively improved upon the ability to address infectious diseases and react to adverse health events through both surgical interventions and pharmacology; we have become efficient in delivering reactive care (i...
March 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/27493630/animal-free-chemical-safety-assessment
#15
REVIEW
George D Loizou
The exponential growth of the Internet of Things and the global popularity and remarkable decline in cost of the mobile phone is driving the digital transformation of medical practice. The rapidly maturing digital, non-medical world of mobile (wireless) devices, cloud computing and social networking is coalescing with the emerging digital medical world of omics data, biosensors and advanced imaging which offers the increasingly realistic prospect of personalized medicine. Described as a potential "seismic" shift from the current "healthcare" model to a "wellness" paradigm that is predictive, preventative, personalized and participatory, this change is based on the development of increasingly sophisticated biosensors which can track and measure key biochemical variables in people...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27387483/application-of-personalized-predictive-preventative-and-participatory-p4-medicine-to-obstructive-sleep-apnea-a-roadmap-for-improving-care
#16
Allan I Pack
Dr. Leroy Hood promotes a paradigm to advance medical care that he calls P4 medicine. The four Ps are: personalized, predictive, preventative, and participatory. P4 medicine encourages a convergence of systems medicine, the digital revolution, and consumer-driven healthcare. Might P4 medicine be applicable to obstructive sleep apnea (OSA)? OSA should be personalized in that there are different structural and physiological pathways to disease. Obesity is a major risk factor. The link between obesity and OSA is likely to be fat deposits in the tongue compromising the upper airway...
September 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27357479/multimorbidity-p4-medicine-and-holism
#17
James A Marcum
RATIONALE, AIMS AND OBJECTIVES: Multimorbidity is a serious challenge to providing patients with quality health care. Sturmberg et al. propose a P4 or whole-person medical model based on a holistic approach to deliver such care. The aim of this commentary is to examine critically their P4 model and holistic approach. METHODS: The P4 model and holistic approach of Sturmberg et al. are analysed conceptually in terms of an effective strategy or sequence for framing P4 medicine and with respect to different philosophical notions of holism for grounding it...
February 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27302209/personalized-medicine-closing-the-gap-between-knowledge-and-clinical-practice
#18
REVIEW
Juan-Manuel Anaya, Carolina Duarte-Rey, Juan C Sarmiento-Monroy, David Bardey, John Castiblanco, Adriana Rojas-Villarraga
Personalized medicine encompasses a broad and evolving field informed by a patient distinctive information and biomarker profile. Although terminology is evolving and some semantic interpretations exist (e.g., personalized, individualized, precision), in a broad sense personalized medicine can be coined as: "To practice medicine as it once used to be in the past using the current biotechnological tools." A humanized approach to personalized medicine would offer the possibility of exploiting systems biology and its concept of P5 medicine, where predictive factors for developing a disease should be examined within populations in order to establish preventive measures on at-risk individuals, for whom healthcare should be personalized and participatory...
August 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27225583/front-matter
#19
(no author information available yet)
The pHealth 2016 Conference is the 13th in a series of scientific events bringing together expertise from medical, technological, political, administrative, legal and social domains. pHealth 2016 opens a new chapter in the success story of the series of international conferences on wearable or implantable micro, nano and biotechnologies for personalized health. Starting in 2003 with personal health management systems, pHealth has continuously extended its scope evolving to a truly interdisciplinary event by covering technological and biomedical facilities, legal, ethical, social, and organizational requirements and impacts as well as necessary basic research for enabling the future proof care paradigms...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/26850380/white-paper-on-p4-concepts-for-pediatric-imaging
#20
Heike E Daldrup-Link, Christina Sammet, Marta Hernanz-Schulman, Katherine A Barsness, Anne Marie Cahill, Ellen Chung, Andrea S Doria, Kassa Darge, Rajesh Krishnamurthy, Matthew P Lungren, Sheila Moore, Laura Olivieri, Ashok Panigrahy, Alexander J Towbin, Andrew Trout, Stephan Voss
Over the past decade, innovations in the field of pediatric imaging have been based largely on single-center and retrospective studies, which provided limited advances for the benefit of pediatric patients. To identify opportunities for potential "quantum-leap" progress in the field of pediatric imaging, the ACR-Pediatric Imaging Research (PIR) Committee has identified high-impact research directions related to the P4 concept of predictive, preventive, personalized, and participatory diagnosis and intervention...
May 2016: Journal of the American College of Radiology: JACR
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