keyword
MENU ▼
Read by QxMD icon Read
search

Predictive, personalized, preventive, participatory

keyword
https://www.readbyqxmd.com/read/27873024/p4%C3%A2-medicine-and-osteoporosis-a%C3%A2-systematic-review
#1
REVIEW
Klemen Kodrič, Klemen Čamernik, Darko Černe, Radko Komadina, Janja Marc
BACKGROUND: Osteoporosis is the most frequent bone metabolic disease. In order to improve early detection, prediction, prevention, diagnosis, and treatment of the disease, a new model of P4 medicine (personalized, predictive, preventive, and participatory medicine) could be applied. The aim of this work was to systematically review the publications of four different types of "omics" studies related to osteoporosis, in order to discover novel predictive, preventive, diagnostic, and therapeutic targets for better management of the geriatric population...
November 21, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27776531/integrating-precision-cancer-medicine-into-healthcare-policy-practice-and-research-challenges
#2
Gabrielle Bertier, Jian Carrot-Zhang, Vassilis Ragoussis, Yann Joly
Precision medicine (PM) can be defined as a predictive, preventive, personalized, and participatory healthcare service delivery model. Recent developments in molecular biology and information technology make PM a reality today through the use of massive amounts of genetic, 'omics', clinical, environmental, and lifestyle data. With cancer being one of the most prominent public health threats in developed countries, both the research community and governments have been investing significant time, money, and efforts in precision cancer medicine (PCM)...
October 24, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27747816/a-tamper-proof-audit-and-control-system-for-the-doctor-in-the-loop
#3
Peter Kieseberg, Bernd Malle, Peter Frühwirt, Edgar Weippl, Andreas Holzinger
The "doctor in the loop" is a new paradigm in information-driven medicine, picturing the doctor as authority inside a loop supplying an expert system with information on actual patients, treatment results, and possible additional (side-)effects, including general information in order to enhance data-driven medical science, as well as giving back treatment advice to the doctor himself. While this approach can be very beneficial for new medical approaches like P4 medicine (personal, predictive, preventive, and participatory), it also relies heavily on the authenticity of the data and thus increases the need for secure and reliable databases...
December 2016: Brain Informatics
https://www.readbyqxmd.com/read/27649826/from-personalized-to-precision-medicine-the-ethical-and-social-implications-of-rhetorical-reform-in-genomic-medicine
#4
Eric Juengst, Michelle L McGowan, Jennifer R Fishman, Richard A Settersten
Since the late 1980s, the human genetics and genomics research community has been promising to usher in a "new paradigm for health care"-one that uses molecular profiling to identify human genetic variants implicated in multifactorial health risks. After the completion of the Human Genome Project in 2003, a wide range of stakeholders became committed to this "paradigm shift," creating a confluence of investment, advocacy, and enthusiasm that bears all the marks of a "scientific/intellectual social movement" within biomedicine...
September 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27638683/personalized-medicine-evidence-of-normativity-in-its-quantitative-definition-of-health
#5
Henrik Vogt, Bjørn Hofmann, Linn Getz
Systems medicine, which is based on computational modelling of biological systems, is emerging as an increasingly prominent part of the personalized medicine movement. It is often promoted as 'P4 medicine' (predictive, preventive, personalized, and participatory). In this article, we test promises made by some of its proponents that systems medicine will be able to develop a scientific, quantitative metric for wellness that will eliminate the purported vagueness, ambiguity, and incompleteness-that is, normativity-of previous health definitions...
October 2016: Theoretical Medicine and Bioethics
https://www.readbyqxmd.com/read/27546358/the-p4-health-spectrum-a-predictive-preventive-personalized-and-participatory-continuum-for-promoting-healthspan
#6
Michael Sagner, Amy McNeil, Pekka Puska, Charles Auffray, Nathan D Price, Leroy Hood, Carl J Lavie, Ze-Guang Han, Zhu Chen, Samir Kumar Brahmachari, Bruce S McEwen, Marcelo B Soares, Rudi Balling, Elissa Epel, Ross Arena
Chronic diseases (i.e., noncommunicable diseases), mainly cardiovascular disease, cancer, respiratory diseases and type-2-diabetes, are now the leading cause of death, disability and diminished quality of life on the planet. Moreover, these diseases are also a major financial burden worldwide, significantly impacting the economy of many countries. Healthcare systems and medicine have progressively improved upon the ability to address infectious diseases and react to adverse health events through both surgical interventions and pharmacology; we have become efficient in delivering reactive care (i...
August 18, 2016: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/27493630/animal-free-chemical-safety-assessment
#7
REVIEW
George D Loizou
The exponential growth of the Internet of Things and the global popularity and remarkable decline in cost of the mobile phone is driving the digital transformation of medical practice. The rapidly maturing digital, non-medical world of mobile (wireless) devices, cloud computing and social networking is coalescing with the emerging digital medical world of omics data, biosensors and advanced imaging which offers the increasingly realistic prospect of personalized medicine. Described as a potential "seismic" shift from the current "healthcare" model to a "wellness" paradigm that is predictive, preventative, personalized and participatory, this change is based on the development of increasingly sophisticated biosensors which can track and measure key biochemical variables in people...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27387483/application-of-personalized-predictive-preventative-and-participatory-p4-medicine-to-obstructive-sleep-apnea-a-roadmap-for-improving-care
#8
Allan I Pack
Dr. Leroy Hood promotes a paradigm to advance medical care that he calls P4 medicine. The four Ps are: personalized, predictive, preventative, and participatory. P4 medicine encourages a convergence of systems medicine, the digital revolution, and consumer-driven healthcare. Might P4 medicine be applicable to obstructive sleep apnea (OSA)? OSA should be personalized in that there are different structural and physiological pathways to disease. Obesity is a major risk factor. The link between obesity and OSA is likely to be fat deposits in the tongue compromising the upper airway...
September 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27357479/multimorbidity-p4-medicine-and-holism
#9
James A Marcum
RATIONALE, AIMS AND OBJECTIVES: Multimorbidity is a serious challenge to providing patients with quality health care. Sturmberg et al. propose a P4 or whole-person medical model based on a holistic approach to deliver such care. The aim of this commentary is to examine critically their P4 model and holistic approach. METHODS: The P4 model and holistic approach of Sturmberg et al. are analysed conceptually in terms of an effective strategy or sequence for framing P4 medicine and with respect to different philosophical notions of holism for grounding it...
June 29, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27302209/personalized-medicine-closing-the-gap-between-knowledge-and-clinical-practice
#10
REVIEW
Juan-Manuel Anaya, Carolina Duarte-Rey, Juan C Sarmiento-Monroy, David Bardey, John Castiblanco, Adriana Rojas-Villarraga
Personalized medicine encompasses a broad and evolving field informed by a patient distinctive information and biomarker profile. Although terminology is evolving and some semantic interpretations exist (e.g., personalized, individualized, precision), in a broad sense personalized medicine can be coined as: "To practice medicine as it once used to be in the past using the current biotechnological tools." A humanized approach to personalized medicine would offer the possibility of exploiting systems biology and its concept of P5 medicine, where predictive factors for developing a disease should be examined within populations in order to establish preventive measures on at-risk individuals, for whom healthcare should be personalized and participatory...
August 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27225583/front-matter
#11
(no author information available yet)
The pHealth 2016 Conference is the 13th in a series of scientific events bringing together expertise from medical, technological, political, administrative, legal and social domains. pHealth 2016 opens a new chapter in the success story of the series of international conferences on wearable or implantable micro, nano and biotechnologies for personalized health. Starting in 2003 with personal health management systems, pHealth has continuously extended its scope evolving to a truly interdisciplinary event by covering technological and biomedical facilities, legal, ethical, social, and organizational requirements and impacts as well as necessary basic research for enabling the future proof care paradigms...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/26850380/white-paper-on-p4-concepts-for-pediatric-imaging
#12
Heike E Daldrup-Link, Christina Sammet, Marta Hernanz-Schulman, Katherine A Barsness, Anne Marie Cahill, Ellen Chung, Andrea S Doria, Kassa Darge, Rajesh Krishnamurthy, Matthew P Lungren, Sheila Moore, Laura Olivieri, Ashok Panigrahy, Alexander J Towbin, Andrew Trout, Stephan Voss
Over the past decade, innovations in the field of pediatric imaging have been based largely on single-center and retrospective studies, which provided limited advances for the benefit of pediatric patients. To identify opportunities for potential "quantum-leap" progress in the field of pediatric imaging, the ACR-Pediatric Imaging Research (PIR) Committee has identified high-impact research directions related to the P4 concept of predictive, preventive, personalized, and participatory diagnosis and intervention...
May 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/26821201/the-new-holism-p4-systems-medicine-and-the-medicalization-of-health-and-life-itself
#13
Henrik Vogt, Bjørn Hofmann, Linn Getz
The emerging concept of systems medicine (or 'P4 medicine'-predictive, preventive, personalized and participatory) is at the vanguard of the post-genomic movement towards 'precision medicine'. It is the medical application of systems biology, the biological study of wholes. Of particular interest, P4 systems medicine is currently promised as a revolutionary new biomedical approach that is holistic rather than reductionist. This article analyzes its concept of holism, both with regard to methods and conceptualization of health and disease...
June 2016: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/26789828/cancer-prevention-state-of-the-art-and-future-prospects
#14
REVIEW
I Valle, D Tramalloni, N L Bragazzi
Cancer imposes a heavy societal burden worldwide, in terms of both epidemiology and costs. The introduction of more sophisticated imaging and diagnostic techniques and advanced drugs that specifically target tumor cells is leading to increasingly expensive treatments, which may be affordable only for few patients. Prevention, and particularly primary prevention, is an effective way of addressing the challenging issue of cancer, since between a third and a half of cancers could be prevented on the basis of our current knowledge of risk factors...
2015: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/26638726/genetic-screening-for-gynecological-cancer-where-are-we-heading
#15
REVIEW
Ranjit Manchanda, Ian Jacobs
The landscape of cancer genetics in gynecological oncology is rapidly changing. The traditional family history-based approach has limitations and misses >50% mutation carriers. This is now being replaced by population-based approaches. The need for changing the clinical paradigm from family history-based to population-based BRCA1/BRCA2 testing in Ashkenazi Jews is supported by data that demonstrate population-based BRCA1/BRCA2 testing does not cause psychological harm and is cost effective. This article covers various genetic testing strategies for gynecological cancers, including population-based approaches, panel and direct-to-consumer testing as well as the need for innovative approaches to genetic counseling...
January 2016: Future Oncology
https://www.readbyqxmd.com/read/26474814/the-2014-espen-arvid-wretlind-lecture-metabolism-nutrition-shifting-paradigms-in-copd-management
#16
REVIEW
Annemie M W J Schols
COPD is a chronic disease of the lungs, but heterogeneous with respect to clinical manifestations and disease progression. This has consequences for health risk assessment, stratification and management. Heterogeneity can be driven by pulmonary events but also by systemic consequences (e.g. cachexia and muscle weakness) and co-morbidity (e.g. osteoporosis, diabetes and cardiovascular disease). This paper shows how a metabolic perspective on COPD has contributed significantly to understanding clinical heterogeneity and the need for a paradigm shift from reactive medicine towards predictive, preventive, personalized and participatory medicine...
December 2015: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/26407063/patient-specific-variations-in-biomarkers-across-gingivitis-and-periodontitis
#17
Radhakrishnan Nagarajan, Craig S Miller, Dolph Dawson, Mohanad Al-Sabbagh, Jeffrey L Ebersole
This study investigates the use of saliva, as an emerging diagnostic fluid in conjunction with classification techniques to discern biological heterogeneity in clinically labelled gingivitis and periodontitis subjects (80 subjects; 40/group) A battery of classification techniques were investigated as traditional single classifier systems as well as within a novel selective voting ensemble classification approach (SVA) framework. Unlike traditional single classifiers, SVA is shown to reveal patient-specific variations within disease groups, which may be important for identifying proclivity to disease progression or disease stability...
2015: PloS One
https://www.readbyqxmd.com/read/26351205/methodologies-and-experimental-platforms-for-generating-and-analysing-microarray-and-mass-spectrometry-based-omics-data-to-support-p4-medicine
#18
Pietro H Guzzi, Giuseppe Agapito, Marianna Milano, Mario Cannataro
Predictive, preventive, personalized and participatory (P4) medicine is an emerging medical model that is based on the customization of all medical aspects (i.e. practices, drugs, decisions) of the individual patient. P4 medicine presupposes the elucidation of the so-called omic world, under the assumption that this knowledge may explain differences of patients with respect to disease prevention, diagnosis and therapies. Here, we elucidate the role of some selected omics sciences for different aspects of disease management, such as early diagnosis of diseases, prevention of diseases, selection of personalized appropriate and optimal therapies based on molecular profiling of patients...
July 2016: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/26337103/novel-therapeutic-strategy-in-the-management-of-copd-a-systems-medicine-approach
#19
REVIEW
Filippo Lococo, Alfredo Cesario, Alessandra Del Bufalo, Alessia Ciarrocchi, Giulia Prinzi, Marco Mina, Stefano Bonassi, Patrizia Russo
Respiratory diseases including chronic-obstructive-pulmonary-disease (COPD) are globally increasing, with COPD predicted to become the third leading cause of global mortality by 2020. COPD is a heterogeneous disease with COPD-patients displaying different phenotypes as a result of a complex interaction between various genetic, environmental and life-style factors. In recent years, several investigations have been performed to better define such interactions, but the identification of the resulting phenotypes is still somewhat difficult, and may lead to inadequate assessment and management of COPD (usually based solely on the severity of airflow limitation parameter FEV1)...
2015: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26292334/a-review-of-emerging-technologies-for-the-management-of-diabetes-mellitus
#20
REVIEW
Konstantia Zarkogianni, Eleni Litsa, Konstantinos Mitsis, Po-Yen Wu, Chanchala D Kaddi, Chih-Wen Cheng, May D Wang, Konstantina S Nikita
OBJECTIVE: High prevalence of diabetes mellitus (DM) along with the poor health outcomes and the escalated costs of treatment and care poses the need to focus on prevention, early detection and improved management of the disease. The aim of this paper is to present and discuss the latest accomplishments in sensors for glucose and lifestyle monitoring along with clinical decision support systems (CDSSs) facilitating self-disease management and supporting healthcare professionals in decision making...
December 2015: IEEE Transactions on Bio-medical Engineering
keyword
keyword
97723
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"