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https://www.readbyqxmd.com/read/29333794/ablation-induced-change-in-the-course-of-fascicular-tachycardia
#1
Avishag Laish-Farkash, Avi Sabbag, Michael Glikson, Aharon Glick, Vladimir Khalameizer, Amos Katz, Yoav Michowitz
BACKGROUND: Multiform fascicular tachycardia (FT) was recently described as a ventricular tachycardia (VT) that has a reentrant mechanism using multiple fascicular branches and produces alternate fascicular VT forms. Ablating the respective fascicle may cause a change in the reentrant circuit resulting in a change in morphology. Ablation of the septal fascicle is crucial for successful treatment. OBJECTIVES: To describe four cases of FT in which ablation induced a change in QRS morphologies and aggravated clinical course...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29326490/investigation-of-in-vitro-absorption-distribution-metabolism-and-excretion-and-in-vivo-pharmacokinetics-of-paromomycin-influence-on-oral-bioavailability
#2
M Jakir S K Pinjari, Rahul Somani, Ritu M Gilhotra
OBJECTIVE: The objective of this study is to investigate in vitro Caco2 permeability, metabolism and in vivo pharmacokinetic (PK) properties of paromomycin to develop an efficient dosage form with improved oral bioavailability. MATERIALS AND METHODS: For the purpose, Caco2 permeability assay, mouse microsomal stability assay and in vivo PKs in male BALB/c mice were performed. RESULTS: In Caco-2 permeability assay, paromomycin showed negligible permeability in the apical to basolateral (A-to-B) direction and vice versa (B-to-A)...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29322918/a-linear-programming-computational-framework-integrates-phosphor-proteomics-and-prior-knowledge-to-predict-drug-efficacy
#3
Zhiwei Ji, Bing Wang, Ke Yan, Ligang Dong, Guanmin Meng, Lei Shi
BACKGROUND: In recent years, the integration of 'omics' technologies, high performance computation, and mathematical modeling of biological processes marks that the systems biology has started to fundamentally impact the way of approaching drug discovery. The LINCS public data warehouse provides detailed information about cell responses with various genetic and environmental stressors. It can be greatly helpful in developing new drugs and therapeutics, as well as improving the situations of lacking effective drugs, drug resistance and relapse in cancer therapies, etc...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29320987/effect-of-intracoronary-agents-on-the-no-reflow-phenomenon-during-primary-percutaneous-coronary-intervention-in-patients-with-st-elevation-myocardial-infarction-a-network-meta-analysis
#4
Xiaowei Niu, Jingjing Zhang, Ming Bai, Yu Peng, Shaobo Sun, Zheng Zhang
BACKGROUND: Despite the restoration of epicardial flow after primary percutaneous coronary intervention (PPCI), myocardial reperfusion remains impaired in a significant proportion of patients. We performed a network meta-analysis to assess the effect of 7 intracoronary agents (adenosine, anisodamine, diltiazem, nicorandil, nitroprusside, urapidil, and verapamil) on the no-reflow phenomenon in patients with ST-elevation myocardial infarction (STEMI) undergoing PPCI. METHODS: Database searches were conducted to identify randomized controlled trials (RCTs) comparing the 7 agents with each other or with standard PPCI...
January 10, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29319234/comparative-pharmacokinetics-of-trandolapril-its-active-metabolite-and-verapamil-in-human-plasma-of-egyptian-population-using-hplc-ms-ms
#5
Ragaa Magdy, Ahmed H El-Khatib, Ahmed Hemdan, Omar Abd Elaziz, Maha Farouk, Michael W Linscheid
Trandolapril and verapamil are commonly used antihypertensive drugs. However, there is a lack of available data on the change of their pharmacokinetics in patients with liver or kidney impairment and hence the need for dose adjustment. In the presented work, a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated for the monitoring of trandolapril, its active metabolite trandolaprilat, and verapamil in human plasma of patients with renal impairment and/or liver insufficiency...
January 10, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29318976/algerian-propolis-potentiates-doxorubicin-mediated-anticancer-effect-against-human-pancreatic-panc-1-cancer-cell-line-through-cell-cycle-arrest-apoptosis-induction-and-p-glycoprotein-inhibition
#6
Hassiba Rouibah, Lahouel Mesbah, Wided Kebsa, Malek Zihlif, Mamoun Ahram, Bachaer Aburmeleih, Ibtihal Mostafa, Hemzeh El Amir
BACKGROUND: Pancreatic cancer is one of the most aggressive and lethal cancer, with poor prognosis and high resistant to current chemotherapeutic agents. Therefore, new therapeutic strategies and targets are underscored. Propolis has been reported to exhibit a broad spectrum of biological activities including anticancer activity. OBJECTIVE: This study was carried out to assess the possible efficacy of Algerian propolis on the antitumor effect of doxorubicin on human pancreatic cancer cell line (PANC-1)...
January 10, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29299132/saikosaponins-a-c-and-d-enhance-liver-targeting-effects-of-anticancer-drugs-by-modulating-drug-transporters
#7
Limin Feng, Lijuan Liu, Ya Zhao, Ruizhi Zhao
Vinegar-baked Radix Bupleuri (VBRB) is clinically used to enhance the pharmacological activity of drugs used to treat liver diseases. Our previous study demonstrated that this effect is dependent on increased drug accumulation in the liver; however, the underlying mechanism remains unclear. We hypothesize that VBRB mediated its effects by altering drug transporters. Thus, the present study was designed to determine the effects of VBRB's main components, saikosaponin A, C, and D, on drug transporters. Transporter activity was determined by measuring the intracellular concentration of transporter substrates...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29299129/cdkn2b-is-critical-for-verapamil-mediated-reversal-of-doxorubicin-resistance-in-hepatocellular-carcinoma
#8
Tengyue Zhang, Kelong Ma, Jin Huang, Shitang Wang, Yabei Liu, Gaofei Fan, Miao Liu, Guangshan Yang, Cheng Wang, Pingsheng Fan
In this study, we explored the function and mechanism of CDKN2B genes in verapamil (VER)-induced reversal of resistance to doxorubicin (ADM) chemotherapy in hepatocellular carcinoma (HCC). We examined 4 HCC cell lines and found that the expression levels of CDKN2B genes correlated with the level of apoptosis induced by ADM+VER. Overexpression of CDKN2B genes promoted apoptosis in cells treated with VER+ADM. CDKN2B knockdown using siRNA weakened the effect of ADM+VER, indicating that ADM+VER promotes HCC cell apoptosis and that CDKN2B genes participate in VER-mediated promotion in tumor cell apoptosis...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29291445/design-synthesis-and-biological-evaluation-of-novel-ring-opened-cromakalim-analogues-with-relaxant-effects-on-vascular-and-respiratory-smooth-muscles-and-as-stimulators-of-elastin-synthesis
#9
Mourad Bouhedja, Basile Peres, Wassim Fhayli, Zeinab Ghandour, Ahcène Boumendjel, Gilles Faury, Smail Khelili
Two new series of ring-opened analogues of cromakalim bearing sulfonylurea moieties (series A: with N-unmethylated sulfonylureas, series B: with N-methylated sulfonylureas) were synthesized and tested as relaxants of vascular and respiratory smooth muscles (rat aorta and trachea, respectively). Ex vivo biological evaluations indicated that the most active compounds, belonging to series B, displayed a marked vasorelaxant activity on endothelium-intact aortic rings and the trachea. A majority of series B compounds exhibited a higher vasorelaxant activity (EC50 < 22 μM) than that of the reference compound diazoxide (EC50 = 24 μM)...
December 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29284860/effect-of-locally-administered-dexmedetomidine-as-adjuvant-to-levobupivacaine-in-supraclavicular-brachial-plexus-block-double-blind-controlled-study
#10
Bikash Bisui, Swastika Samanta, Sumanta Ghoshmaulik, Amit Banerjee, Tirtha R Ghosh, Suman Sarkar
Context: Brachial plexus block is effective with good postoperative analgesia in upper limb surgery has gained importance as it safe, low cost, and maintains stable hemodynamics intraoperatively. To decrease the onset time and prolong the duration of nerve block bicarbonate, opioids (morphine, fentanyl, etc.), sympathomimetic agents (epinephrine, phenylephrine, etc.), α-2 agonists (clonidine and dexmedetomidine), calcium channel blocker (verapamil), magnesium sulfate, etc., were studied with local anesthetics and their isomers...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29282183/techniques-for-optimizing-surgical-scars-part-2-hypertrophic-scars-and-keloids
#11
Kathryn Potter, Sailesh Konda, Vicky Zhen Ren, Apphia Lihan Wang, Aditya Srinivasan, Suneel Chilukuri
Surgical management of benign or malignant cutaneous tumors may result in noticeable scars that are of great concern to patients, regardless of sex, age, or ethnicity. Techniques to optimize surgical scars are discussed in this three-part review. Part 2 focuses on scar revision for hypertrophic and keloids scars. Scar revision options for hypertrophic and keloid scars include corticosteroids, bleomycin, fluorouracil, verapamil, avotermin, hydrogel scaffold, nonablative fractional lasers, ablative and fractional ablative lasers, pulsed dye laser (PDL), flurandrenolide tape, imiquimod, onion extract, silicone, and scar massage...
2017: Skinmed
https://www.readbyqxmd.com/read/29274391/electrophysiological-characteristics-and-pharmacological-sensitivity-of-two-lines-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-coming-from-two-different-suppliers
#12
Sonia Goineau, Vincent Castagné
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly used as preclinical tool for predicting drug-induced QT prolongation and arrhythmias. This study was conducted to assess the electrophysiological characteristics and the pharmacological sensitivity of two commercialized hiPSC-CMs. The baseline electrophysiological characteristics measured with a multi-electrode array (MEA) technology differ between Cor.4U and iCell2: higher beat rate (+32bpm) and shorter field potential duration (FPD, -201ms) for Cor...
December 20, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29273711/lucs-light-up-cell-system-a-universal-high-throughput-assay-for-homeostasis-evaluation-in-live-cells
#13
Sylvain Derick, Camille Gironde, Pierre Perio, Karine Reybier, Françoise Nepveu, Alain Jauneau, Christophe Furger
Observations of fluorescent cyanine dye behavior under illumination at 500 nm lead to a novel concept in cell biology allowing the development of a new live cell assay called LUCS, for Light-Up Cell System, measuring homeostasis in live cells. Optimization of the LUCS process resulted in a standardized, straightforward and high throughput assay with applications in toxicity assessment. The mechanisms of the LUCS process were investigated. Electron Paramagnetic Resonance experiments showed that the singlet oxygen and hydroxyl radical are involved downstream of the light effect, presumably leading to deleterious oxidative stress that massively opens access of the dye to its intracellular target...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29247488/oxaliplatin-resistance-in-colorectal-cancer-cells-is-mediated-via-activation-of-abcg2-to-alleviate-er-stress-induced-apoptosis
#14
Hsi-Hsien Hsu, Ming-Cheng Chen, Rathinasamy Baskaran, Yueh-Min Lin, Cecilia Hsuan Day, Yi-Jiun Lin, Chuan-Chou Tu, Viswanadha Vijaya Padma, Wei-Wen Kuo, Chih-Yang Huang
Oxaliplatin (OXA), is a third generation platinum drug used as first-line chemotherapy in colorectal cancer (CRC). Cancer cells acquires resistance to anti-cancer drug and develops resistance. ATP-binding cassette (ABC) drug transporter ABCG2, one of multidrug resistance (MDR) protein which can effectively discharge a wide spectrum of chemotherapeutic agents out of cancer cells and subsequently reduce the intracellular concentration of these drugs. Role of ABCG2 and plausible molecular signaling pathways involved in Oxaliplatin-Resistant (OXA-R) colon cancer cells was evaluated in the present study...
December 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29239759/alternative-treatment-options-for-atrioventricular-nodal-reentry-tachycardia-an-emergency-medicine-review
#15
Sarah Brubaker, Brit Long, Alex Koyfman
BACKGROUND: Atrioventricular-nodal-reentry tachycardia (AVNRT) is a form of supraventricular tachycardia (SVT) that is relatively common in the emergency department (ED). It is rarely indicative of underlying electrical or structural pathology. OBJECTIVE: This review evaluates the literature and controversies concerning treatment of AVNRT in the ED. DISCUSSION: For treatment of narrow-complex tachycardia, Advanced Cardiovascular Life Support guidelines recommend the use of vagal maneuvers, followed by adenosine...
November 24, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29239000/minimal-physiologically-based-pharmacokinetic-and-drug-drug-disease-interaction-model-of-rivaroxaban-and-verapamil-in-healthy-and-renally-impaired-subjects
#16
Mohamed Ismail, Vincent H Lee, Christina R Chow, Christopher M Rubino
Current dosing recommendations for rivaroxaban advocate dosage reduction in patients with moderate to severe renal impairment and avoidance of concomitant strong inhibitors of CYP3A or P-glycoprotein. However, rivaroxaban dosing in patients with mild renal impairment taking concomitant moderate inhibitors of CYP3A and P-glycoprotein is not addressed. To quantify the impacts of concomitant verapamil administration and renal impairment on rivaroxaban pharmacokinetics, a minimal physiologically based pharmacokinetic model system was developed and used to evaluate potential increases in rivaroxaban exposure and the consequent increase in risk of major bleeding...
December 14, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29237099/calcium-channel-blockers-for-primary-and-secondary-raynaud-s-phenomenon
#17
REVIEW
Fadumo Rirash, Paul C Tingey, Sarah E Harding, Lara J Maxwell, Elizabeth Tanjong Ghogomu, George A Wells, Peter Tugwell, Janet Pope
BACKGROUND: Raynaud's phenomenon is a vasospastic disease characterized by digital pallor, cyanosis, and extremity pain. Primary Raynaud's phenomenon is not associated with underlying disease, but secondary Raynaud's phenomenon is associated with connective tissue disorders such as systemic sclerosis, systemic lupus erythematosus, and mixed connective tissue disease. Calcium channel blockers promote vasodilation and are commonly used when drug treatment for Raynaud's phenomenon is required...
December 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29236925/increased-thiol-levels-in-antimony-resistant-leishmania-infantum-isolated-from-treatment-refractory-visceral-leishmaniasis-in-brazil
#18
Lucas S Magalhães, Lays Gs Bomfim, Sthefanne G Mota, Geydson S Cruz, Cristiane B Corrêa, Diego M Tanajura, Michael W Lipscomb, Valéria M Borges, Amélia R de Jesus, Roque P de Almeida, Tatiana R de Moura
BACKGROUND Treatment-refractory visceral leishmaniasis (VL) has become an important problem in many countries. OBJECTIVES We evaluated the antimony-resistance mechanisms of Leishmania infantum isolated from VL patients refractory or responsive to treatment with pentavalent antimony. METHODS Strains isolated from antimony-refractory patients (in vitro antimony-resistant isolates) and antimony-responsive patients (in vitro antimony-sensitive isolates) were examined. Morphological changes were evaluated by transmission electron microscopy after trivalent antimony exposure...
February 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29234422/effect-of-gelsemium-elegans-and-mussaenda-pubescens-the-components-of-a-detoxification-herbal-formula-on-disturbance-of-the-intestinal-absorptions-of-indole-alkaloids-in-caco-2-cells
#19
Yinghao Wang, Heshan Wang, Shuisheng Wu, Desen Li, Sainan Chen
Gelsemium elegans (GE) is a kind of well-known toxic plant. It can be detoxified by Mussaenda pubescens (MP), but the detoxification mechanism is still unclear. Thus, a detoxification herbal formula (GM) comprising GE and MP was derived. The Caco-2 cells monolayer model was used to evaluate GM effects on transporting six kinds of indole alkaloids of GE. The bidirectional transport studies demonstrated that absorbance percentage of indole alkaloids in GE increased linearly over time. But in GM, Papp (AP→BL) values of the most toxic members, gelsenicine, humantenidine, and gelsevirine, were lower than that of Papp (BL→AP) (P < 0...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29226995/change-in-qrs-morphology-as-a-marker-of-spontaneous-elimination-in-verapamil-sensitive-idiopathic-left-ventricular-tachycardia
#20
Hiroshi Kawakami, Takeshi Aiba, Kohei Ishibashi, Ikutaro Nakajima, Mitsuru Wada, Tsukasa Kamakura, Yuko Inoue, Koji Miyamoto, Hideo Okamura, Satoshi Nagase, Takashi Noda, Yoshihiro Kokubo, Yoshihiro Miyamoto, Satoshi Yasuda, Shiro Kamakura, Kengo Kusano
BACKGROUND: Verapamil-sensitive idiopathic left ventricular tachycardia (verapamil-ILVT) is thought to be due to a reentry within the LV fascicular system. Radiofrequency catheter ablation (RFCA) is effective for elimination of the VT; however, a long-term prognosis of patients with verapamil-ILVT is still unclear. METHODS AND RESULTS: Eighty consecutive verapamil-ILVT patients (62 men, 31±12 years-of-age, LVEF: 65±4%) were enrolled. Seventy-six (95%) cases of VT involved right bundle brunch block and left axis deviation...
December 11, 2017: Journal of Cardiovascular Electrophysiology
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