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https://www.readbyqxmd.com/read/24718781/generation-of-high-yield-insulin-producing-cells-from-human-bone-marrow-mesenchymal-stem-cells
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Arefeh Jafarian, Mohammad Taghikhani, Saeid Abroun, Zahra Pourpak, Amir Allahverdi, Masoud Soleimani
Allogenic islet transplantation is a most efficient approach for treatment of diabetes mellitus. However, the scarcity of islets and long term need for an immunosuppressant limits its application. Recently, cell replacement therapies that generate of unlimited sources of β cells have been developed to overcome these limitations. In this study we have described a stage specific differentiation protocol for the generation of insulin producing islet-like clusters from human bone marrow mesenchymal stem cells (hBM-MSCs)...
July 2014: Molecular Biology Reports
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