keyword
https://read.qxmd.com/read/37089964/epithelioid-myofibroblastoma-with-concurrent-presentation-of-lcis-and-dcis
#21
Amer Safdari, Lucas Sage, Manmeet Singh, Lauren Green
Myofibroblastoma (MFB) of the breast is a rare benign neoplasm of the mammary stroma. Several morphologic variants have been described in the literature, which can create diagnostic challenges for pathologists, in particular the epithelioid variant of MFB, which can mimic invasive lobular carcinoma. We report a case of a 72-year-old female who presented for a painless breast lump and was later found to have 2 lesions on imaging, with 1 lesion corresponding to the palpable lump and the other lying in a different quadrant...
June 2023: Radiology Case Reports
https://read.qxmd.com/read/36935376/examination-of-large-chromosomal-inversions-in-the-genome-of-erwinia-amylovora-strains-reveals-worldwide-distribution-and-north-america-specific-types
#22
JOURNAL ARTICLE
Ho-Wen Yang, Ranjita Thapa, Kenneth Johnson, S Tianna Dupont, Awais Khan, Youfu Zhao
Erwinia amylovora is a relatively homogeneous species with low genetic diversity at the nucleotide level. However, phenotypic differences and genomic structural variations among E. amylovora strains have been documented. In this study, we identified 10 large chromosomal inversion (LCI) types in the Spiraeoideae-infecting (SI) E. amylovora strains by combining whole genome sequencing and PCR-based molecular markers. It was found that LCIs were mainly caused by homologous recombination events among seven rRNA operons (rrns) in SI E...
March 19, 2023: Phytopathology
https://read.qxmd.com/read/36917758/randomized-placebo-controlled-trial-of-low-dose-tamoxifen-to-prevent-recurrence-in-breast-noninvasive-neoplasia-a-10-year-follow-up-of-tam-01-study
#23
RANDOMIZED CONTROLLED TRIAL
Matteo Lazzeroni, Matteo Puntoni, Aliana Guerrieri-Gonzaga, Davide Serrano, Luca Boni, Tania Buttiron Webber, Marianna Fava, Irene M Briata, Livia Giordano, Maria Digennaro, Laura Cortesi, Fabio Falcini, Patrizia Serra, Franca Avino, Francesco Millo, Katia Cagossi, Elisa Gallerani, Alessia De Simone, Anna Cariello, Giuseppe Aprile, Maria Renne, Bernardo Bonanni, Andrea DeCensi
PURPOSE: Five-year data of the phase III trial TAM-01 showed that low-dose tamoxifen at 5 mg once daily administered for 3 years in women with intraepithelial neoplasia (IEN) reduced by 52% the recurrence of invasive breast cancer or ductal carcinoma in situ (DCIS), without additional adverse events over placebo. Here, we present the 10-year results. METHODS: We randomly assigned 500 women with breast IEN (atypical ductal hyperplasia, lobular carcinoma in situ [LCIS], or hormone-sensitive or unknown DCIS) to low-dose tamoxifen or placebo after surgery with or without irradiation...
June 10, 2023: Journal of Clinical Oncology
https://read.qxmd.com/read/36900322/insight-into-the-crosstalk-between-photodynamic-therapy-and-immunotherapy-in-breast-cancer
#24
REVIEW
Hongzhong Jin, Shichong Liao, Feng Yao, Juanjuan Li, Zhiliang Xu, Kailiang Zhao, Ximing Xu, Shengrong Sun
Breast cancer (BC) is the world's second most frequent malignancy and the leading cause of mortality among women. All in situ or invasive breast cancer derives from terminal tubulobular units; when the tumor is present only in the ducts or lobules in situ, it is called ductal carcinoma in situ (DCIS)/lobular carcinoma in situ (LCIS). The biggest risk factors are age, mutations in breast cancer genes 1 or 2 (BRCA1 or BRCA2), and dense breast tissue. Current treatments are associated with various side effects, recurrence, and poor quality of life...
February 28, 2023: Cancers
https://read.qxmd.com/read/36891065/derivation-and-assessment-of-regional-electricity-generation-emission-factors-in-the-usa
#25
JOURNAL ARTICLE
Tapajyoti Ghosh, Wesley W Ingwersen, Matthew Jamieson, Troy R Hawkins, Sarah Cashman, Troy Hottle, Alberta Carpenter, Kirti Richa
PURPOSE: Electricity production is one of the largest sources of environmental emissions-especially greenhouse gases (GHGs)-in the USA. Emission factors (EFs) vary from region to region, which requires the use of spatially relevant EF data for electricity production while performing life cycle assessments (LCAs). Uncertainty information, which is sought by LCA practitioners, is rarely supplied with available life cycle inventories (LCIs). METHODS: To address these challenges, we present a method for collecting data from different sources for electricity generation and environmental emissions; discuss the challenges involved in agglomerating such data; provide relevant suggestions and solutions to merge the information; and calculate EFs for electricity generation processes from various fuel sources for different spatial regions and spatial resolutions...
December 19, 2022: International Journal of Life Cycle Assessment
https://read.qxmd.com/read/36654721/gastrointestinal-tract-metastasis-with-subsequent-intussusception-and-obstruction-from-an-invasive-lobular-breast-cancer-a-case-report
#26
Binit Katuwal, Donald Morin, Ramachandra Kolachalam
Breast cancer is the commonest cancer in female population with lobular subtype comprising about 10% of all breast cancers. Breast cancer metastasis occurs in 0.3-18% of patients, with lobular cancer again being the most common subtype. We present an 85-year-old female with previous history of right breast lobular carcinoma in situ (LCIS), who was diagnosed to have lobular carcinoma of breast metastasising to stomach after 10 years of initial diagnosis. After 2 years, the patient was found to have metastasis to the terminal ileum and caecum causing intussusception, which led to obstruction...
January 2023: Journal of Surgical Case Reports
https://read.qxmd.com/read/36581929/proliferative-epithelial-changes-in-tumour-adjacent-tissue-in-sri-lankan-women-with-breast-carcinoma-do-morphological-changes-support-molecular-models-of-breast-carcinogenesis
#27
JOURNAL ARTICLE
Indumini Maheshika Jinadasa, Harshima Disvini Wijesinghe, Modini Manohari Abeydera Jayawickrama, Menaka Dilani Samarawickrama Lokuhetty
BACKGROUND: The multistep molecular model of breast carcinogenesis is based on the oestrogen receptor(ER) status of the tumour. Its two main arms comprise ER-positive and ER-negative breast carcinomas(BCa), which are associated with Nottingham grade(NG) of the tumour and different proliferative epithelial changes. According to the model, columnar cell lesions(CCL), lobular carcinoma in-situ(LCIS) and atypical ductal hyperplasia(ADH), low-grade ductal carcinoma in-situ (LG-DCIS) are associated with low grade ER-positive tumours and microglandular adenosis (MGA), pleomorphic LCIS(PLCIS), high-grade DCIS(HG-DCIS) are associated with ER-negative high grade tumours...
December 29, 2022: Diagnostic Pathology
https://read.qxmd.com/read/36335930/lobular-neoplasia
#28
REVIEW
Lilia Lunt, Alison Coogan, Claudia B Perez
Lobular neoplasia (LN) is a term that describes atypical epithelial lesions originating in the terminal duct-lobular unit (TDLU) of the breast, including atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS). LN is both a risk factor and nonobligate precursor to invasive breast cancer. A diagnosis of LCIS is associated with a 7-to-10-fold increased risk of breast cancer compared with the general population. When classic LN is diagnosed on a core needle biopsy (CNB), the patient may proceed with either increased screening or excisional biopsy of the lesion...
December 2022: Surgical Clinics of North America
https://read.qxmd.com/read/36310540/incorporating-new-technologies-in-eeio-models
#29
JOURNAL ARTICLE
Cindy G Azuero-Pedraza, Valerie M Thomas, Wesley W Ingwersen
We propose a methodology to add new technologies into Environmentally Extended Input-Output (EEIO) models based on a Supply and Use framework. The methodology provides for adding new industries (new technologies) and a new commodity under the assumption that the new commodity will partially substitute for a functionally-similar existing commodity of the baseline economy. The level of substitution is controlled by a percentage (%) as a variable of the model. In the Use table, a percentage of the current use of the existing commodity is transferred to the new commodity...
July 12, 2022: Applied Sciences
https://read.qxmd.com/read/36270911/fine-needle-aspiration-of-intramammary-lymph-nodes-a-clinical-radiographic-and-cytologic-review
#30
JOURNAL ARTICLE
Lin Cheng, Hamza Tariq, Lei Yan, Swathi B Reddy, Paolo Gattuso
INTRODUCTION: Recognizing and sampling intramammary lymph nodes (IMLNs) is important in the clinical management of patients with breast carcinomas. We undertook a retrospective study to evaluate the clinical utility of fine-needle aspiration (FNA) in assessing IMLNs. MATERIALS AND METHODS: Our pathology database was searched for all IMLN FNA cytology cases from January 2005 to December 2021. The cytologic findings, radiographic features, and clinical data were reviewed...
September 22, 2022: Journal of the American Society of Cytopathology
https://read.qxmd.com/read/36242709/high-risk-lesions-in-the-breast-diagnosed-by-mri-guided-core-biopsy-upgrade-rates-and-features-associated-with-malignancy
#31
JOURNAL ARTICLE
Eumee Cha, Emily B Ambinder, Eniola T Oluyemi, Lisa A Mullen, Babita Panigrahi, Joanna Rossi, Philip A Di Carlo, Kelly S Myers
PURPOSE: This study assessed the upgrade rates of high-risk lesions (HRLs) in the breast diagnosed by MRI-guided core biopsy and evaluated imaging and clinical features associated with upgrade to malignancy. METHODS: This IRB-approved, retrospective study included MRI-guided breast biopsy exams yielding HRLs from August 1, 2011, to August 31, 2020. HRLs included atypical ductal hyperplasia (ADH), lobular carcinoma in situ (LCIS), atypical lobular hyperplasia (ALH), radial scar, and papilloma...
October 15, 2022: Breast Cancer Research and Treatment
https://read.qxmd.com/read/36171529/screening-mri-does-not-increase-cancer-detection-or-result-in-an-earlier-stage-at-diagnosis-for-patients-with-high-risk-breast-lesions-a-propensity-score-analysis
#32
JOURNAL ARTICLE
Alison Laws, Fisher Katlin, Marybeth Hans, Mary Graichen, Olga Kantor, Christina Minami, Brittany L Bychkovsky, Lydia E Pace, Rochelle Scheib, Judy E Garber, Tari A King
BACKGROUND: Guidelines recommend consideration of screening MRI for patients with high-risk breast lesions (HRLs), acknowledging limited data for this moderate-risk population. METHODS: This study identified patients with atypical ductal/lobular hyperplasia (ADH/ALH), lobular carcinoma in situ, (LCIS) or both evaluated at our high-risk clinic. Patients were categorized as having received screening mammography (MMG) alone vs. MMG and breast MRI (MMG+MRI). Inverse probability weighting based on propensity scores (PS) representing likelihood of MRI use was applied to Kaplan-Meier and Cox regression analyses to determine cancer detection and biopsy rates by screening group...
September 28, 2022: Annals of Surgical Oncology
https://read.qxmd.com/read/36155050/an-approach-to-regionalise-the-life-cycle-inventories-of-spanish-agriculture-monitoring-the-environmental-impacts-of-orange-and-tomato-crops
#33
JOURNAL ARTICLE
Nelson Sinisterra-Solís, Neus Sanjuán, Javier Ribal, Vicent Estruch, Gabriela Clemente
Agricultural life cycle assessment (LCA) at the sub-national regional level may be a valuable input for the decision-makers. Obtaining representative and sufficient data to develop life cycle inventories (LCIs) at that level is a relevant challenge. This study aims to contribute to the development of LCIs representative Spanish crops based on average economic and operational information available in official sources to assess the average environmental impacts of these crops in the main producing regions. A comprehensive approach is proposed considering both the temporal variability and uncertainty of input data by using different methods (e...
September 22, 2022: Science of the Total Environment
https://read.qxmd.com/read/36069388/prophylactic-mastectomy-and-occult-malignancy-surgical-and-imaging-considerations
#34
JOURNAL ARTICLE
Jessica L Thompson, Brandy R Sinco, Rachel L McCaffrey, Alfred E Chang, Michael S Sabel, Lesly A Dossett, Tasha M Hughes, Jacqueline S Jeruss
BACKGROUND: Sentinel node biopsy (SLNB) is not routinely recommended for patients undergoing prophylactic mastectomy (PM), yet omission remains a subject of debate among surgeons. A modern patient cohort was examined to determine occult malignancy (OM) incidence within PM specimens to reinforce current recommendations. METHODS: All PM performed over a 5-year period were retrospectively identified, including women with unilateral breast cancer who underwent synchronous or delayed contralateral PM or women with elevated cancer risk who underwent bilateral PM...
January 2023: Journal of Surgical Oncology
https://read.qxmd.com/read/35998819/alpha-methylacyl-coa-racemase-amacr-protein-is-upregulated-in-early-proliferative-lesions-of-the-breast-irrespective-of-apocrine-differentiation
#35
JOURNAL ARTICLE
Zoran Gatalica, Phillip Stafford, Semir Vranic
Alpha-methylacyl-CoA racemase (AMACR/P504S) is a mitochondrial and peroxisomal enzyme involved in the branched-chain fatty acid and bile acid metabolism. AMACR is a useful diagnostic biomarker for prostate carcinomas and several other malignancies. Its expression in apocrine breast lesions had been previously reported, but its role in breast cancer progression has not been fully investigated. One hundred fifty breast samples (80 with invasive carcinomas) were studied. The expression of AMACR protein was analyzed using the immunohistochemical method (IHC)...
November 2022: Human Pathology
https://read.qxmd.com/read/35951136/the-influence-of-body-mass-index-on-the-histopathology-and-outcomes-of-patients-diagnosed-with-atypical-breast-lesions
#36
JOURNAL ARTICLE
Krislyn N Miller, Samantha M Thomas, Amanda R Sergesketter, Laura H Rosenberger, Gayle DiLalla, Astrid Botty van den Bruele, E Shelley Hwang, Jennifer K Plichta
BACKGROUND: Multiple studies have demonstrated a link between obesity and breast cancer; however, the potential association between obesity and atypical high-risk breast lesions has not been well characterized. We sought to evaluate the characteristics and clinical outcomes of patients with breast atypia based on a woman's body mass index (BMI). METHODS: We retrospectively identified adult women diagnosed with atypical ductal hyperplasia (ADH), atypical lobular hyperplasia (ALH), and/or lobular carcinoma in situ (LCIS) at a single institution from 2008 to 2017...
August 11, 2022: Annals of Surgical Oncology
https://read.qxmd.com/read/35869801/dataset-for-pathology-reporting-of-ductal-carcinoma-in%C3%A2-situ-variants-of-lobular-carcinoma-in%C3%A2-situ-and-low-grade-lesions-recommendations-from-the-international-collaboration-on-cancer-reporting-iccr
#37
REVIEW
Stephen B Fox, Fluer Webster, Chih-Jung Chen, Boon Chua, Laura Collins, Maaria-Pia Foschini, G Bruce Mann, Ewan Millar, Sarah E Pinder, Emad Rakha, Abeer Shaaban, Benjamin Y Tan, Gary Tse, Peter Watson, Puy Hoon Tan
AIMS: To describe a new international dataset for pathology reporting of ductal carcinoma in situ (DCIS), variants of lobular carcinoma in situ (LCIS) and low-grade lesions (encapsulated papillary carcinoma, solid papillary carcinoma in situ, Paget's disease) produced by the International Collaboration on Cancer Reporting (ICCR). METHODS AND RESULTS: The ICCR, a global alliance of pathology bodies, uses a rigorous and efficient process for the development of evidence-based, structured datasets for pathology reporting of common cancers...
October 2022: Histopathology
https://read.qxmd.com/read/35861759/aso-visual-abstract-the-presence-of-non-classic-lcis-is-not-a-contraindication-to-breast-conservation-in-patients-with-concomitant-invasive-breast-cancer-or-dcis
#38
JOURNAL ARTICLE
Faina Nakhlis, Fisher D Katlin, Samantha C Grossmith, Ashley DiPasquale, Beth T Harrison, Stuart J Schnitt, Tari A King
No abstract text is available yet for this article.
July 21, 2022: Annals of Surgical Oncology
https://read.qxmd.com/read/35771367/presence-of-non-classic-lcis-is-not-a-contraindication-to-breast-conservation-in-patients-with-concomitant-invasive-breast-cancer-or-dcis
#39
JOURNAL ARTICLE
Faina Nakhlis, Fisher D Katlin, Samantha C Grossmith, Ashley DiPasquale, Beth T Harrison, Stuart J Schnitt, Tari A King
BACKGROUND: Non-classic lobular carcinoma in situ (NC-LCIS) represents a spectrum of lesions, histologically distinct from classic LCIS (C-LCIS) and ductal carcinoma in situ (DCIS). Several studies have reported on the safety of breast conservation (BCS) in patients with DCIS or invasive breast cancer and concomitant C-LCIS, yet there are no data addressing this question for patients with concomitant NC-LCIS. We evaluated local recurrence (LR) after BCS in patients with DCIS or invasive cancer and concomitant NC-LCIS...
November 2022: Annals of Surgical Oncology
https://read.qxmd.com/read/35735255/canine-and-feline-in-situ-mammary-carcinoma-a-comparative-review
#40
JOURNAL ARTICLE
Giovanni P Burrai, Valeria Baldassarre, Barbara Brunetti, Selina Iussich, Lorella Maniscalco, Francesca Mariotti, Alessandra Sfacteria, Cristiano Cocumelli, Valeria Grieco, Francesca Millanta, Orlando Paciello, Serenella Papparella, Roberta Rasotto, Mariarita Romanucci, Valentina Zappulli
Carcinoma in situ of the breast is a well-known entity in humans. In veterinary medicine, particularly in canine and feline mammary literature, there is no agreement whether the term in situ should be used to indicate a specific carcinoma histotype or the noninvasive status of a carcinoma of any histotype. Moreover, in the most recent histologic classification of mammary tumors published by the Davis-Thompson Foundation, it is suggested to abandon the term carcinoma in situ given the lack of standardized criteria defining this entity, replacing it with epitheliosis or ductal/lobular hyperplasia with severe atypia...
June 23, 2022: Veterinary Pathology
keyword
keyword
9771
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.